• Allergy and Immunology Clinical Trials

    We at the Division of Allergy and Immunology at Cincinnati Children’s are devoted to providing the best care for our patients. Our dedicated clinical staff partner with families to improve the health and quality of life of our patients. Our involvement in human research studies, also known as clinical trials, helps us to determine what treatments and strategies work best for our patients. Our division’s clinical trials team is dedicated to bringing cutting-edge therapies to our child and adult patients. 

  • Ongoing Clinical Trials

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    Testing the Effectiveness of Losartan in Participants With EoE, With or Without a Connective Tissue Disorder

    CCHMC IRB # 2012-0106: V2

    The Cincinnati Center for Eosinophilic Disorders is conducting a research study to test whether losartan decreases the number of eosinophils in the esophagus of participants with active EoE, with or without a connective tissue disorder (CTD).

    What

    We are enrolling participants for a 4 month open label drug trial. This involves several visits to Cincinnati Children’s, blood draws, biopsies taken from EGD, and having vitals taken.

    How

    Participation will take place at Cincinnati Children’s, over the phone and through the mail.

    Who

    People with active EoE with or without a CTD

    Contact

    If you have questions or are interested in participating, contact Melody Hess at melody.hess@cchmc.org or (513) 636-5540.

    Read More

    Eosinophilic Esophagitis Medication Study (PDF)

    Do You or a Loved One Have a Peanut Allergy?

    CCHMC IRB #2012-1498:V1

    Needed: 

    6 to 55 Year Olds for Peanut Allergy Medication Research Study

    What

    This is a research study to evaluate the safety and effectiveness of the investigational medication Viaskin® Peanut for treating peanut allergy in children and adults.

    Why

    To date, there is no specific approved treatment for peanut allergy, which can be quite severe and life-threatening. The only management recommended for patients allergic to peanuts is strict avoidance. However, peanut is a very common ingredient in many foods and is not always reported in all ingredients.

    Who

    Children and adults 6 to 55 years old who have a well-documented history of peanut allergy and are currently following a strict peanut-free diet may be eligible to participate.

    Compensation

    Participants may receive up to $480 for travel related expenses for completing all 12 study visits ($40 per completed study visit).

    Details

    For more information, please email foodstudies@cchmc.org or call 1-513-803-FOOD

    Read More

    Cincinnati Children's Peanut Allergy Study (PDF)

  • Recently Completed Clinical Trials

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    Do You or Your Child Have Asthma? Do You or Your Child Take an Oral Steroid Every Day for that Asthma?

    CCHMC IRB #2012-2698:V1

    What

    This is a research study to learn more about the safety and effectiveness of a drug called mepolizumab in treating asthma. Researchers want to know if mepolizumab can lower the amount of oral steroids a person needs to take to treat their asthma.

    Who

    Children, teens and adults 12 years old and older who:

    • Have asthma        
    AND

    • Take steroid medicine by mouth (orally) every day to treat their asthma

    Pay

    Participants may be paid up to $465 for completing all study visits.

    Details

    For more information, please contact Erin Brockman at erin.brockman@cchmc.org or 513-636-7897.

    Read More

    Cincinnati Children's Asthma Medication Research Study (PDF)

    Are You An Adult with Asthma? 
    Do You Still Use an Inhaler?

    Investigational Asthma Medication Research Study

    CCHMC IRB #2012-1422:V1

    What

    The purpose of this research study is to evaluate the safety and effectiveness of an investigational medication. The study will examine whether this medication is beneficial in improving lung function in patients with moderate to severe asthma and compare its effectiveness among certain types of patients.

    Who

    Adults 18 to 75 years old who:

    • Have been diagnosed with moderate or severe asthma
    • Are on an inhaled corticosteroid (like Flovent, Advair, etc.)

    Pay

    Participants may receive compensation for their travel and time.

    Details

    For more information, please email asthmastudies@cchmc.org or call 1-513-636-AZMA

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    Cincinnati Children's Moderate to Severe Asthma Study

    Needed: Children, Teens and Adults 12 Years or Older Who Have Severe Asthma

    CCHMC IRB #2012-2702:V1

    What

    This is a research study to learn more about the safety and effectiveness of a new drug, called mepolizumab, in treating asthma. 

    Researchers also want to know how the body reacts to the drug and if there is a change in the number of asthma attacks a person has while taking mepolizumab. 

    Who

    Children, teens and adults 12 years old and older who been diagnosed with asthma AND:

    • Have been using a steroid inhaler for 12 months
    • Have been in the hospital or emergency room at least 2 times because of their asthma

    Pay

    Participants may receive compensation for their travel and time. 

    Details

    For more information, contact Erin Brockman at erin.brockman@cchmc.org or 513-636-7897.

    Read More

    Cincinnati Children's Severe Asthma Medication Research Study (PDF)

  • We are devoted to providing the best care.

    Our clinician researchers, such as Amal H. Assa'ad, MD, are devoted to providing the best in pediatric and adult care. 

  • Our clinical trials are also open to adults.

    Our clinical trials are not only for children. See the Ongoing Clinical Trials descriptions (left) for specifics of who are eligible to participate.