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Eosinophilic disorders occur when eosinophils, a type of white blood cell, are found in above-normal amounts in various parts of the body. When the body produces too many eosinophils, they can cause chronic inflammation, resulting in tissue damage and a range of clinical symptoms. These rare diseases are diagnosed according to where the elevated levels of eosinophils are found: eosinophilic colitis (large intestine), eosinophilic enteritis (small intestine), eosinophilic esophagitis (esophagus), eosinophilic gastritis (stomach) and hypereosinophilic syndrome (blood and any organ). The most common of these rare disorders is eosinophilic esophagitis, which has symptoms resembling gastroesophageal reflux disease including trouble swallowing, vomiting, abdominal pain and food getting stuck in the esophagus. Treatments for eosinophilic disorders include changes in diet and prescription medications, and Cincinnati Children’s is one of very few centers with expertise in diagnosing, treating, and researching these disorders in children and adults.
Visit the Cincinnati Center for Eosinophilic Disorders.
For people with food allergies, their immune systems overact to the proteins of a certain food or foods, resulting in an allergic reaction that can include symptoms such as a rash or red, itchy skin; stuffy or itchy nose, sneezing or itchy and teary eyes; or vomiting, stomach cramps or diarrhea, angioedema or swelling. Severe food allergies can sometimes result in a life-threatening reaction called anaphylaxis, which may have symptoms such as hoarseness, throat tightness or lump in the throat; wheezing, chest tightness or trouble breathing; or tingling in the hands or feet, lips or scalp. Many foods can cause food allergies; however, the most common are cow’s milk, eggs, peanuts, wheat, soy, fish, shellfish, and tree nuts (almonds, walnuts, hazelnuts, Brazil nuts, pecans). Management of food allergy typically includes elimination of the reaction-causing food from the diet, other avoidance precautions to limit exposure to the reaction-causing food and a plan of action in case of accidental exposure. More recently, exciting clinical trials have shown the value of food tolerance protocols in the treatment of food allergy.
Our division has specialized clinics and closely collaborates with other centers and divisions within Cincinnati Children’s.
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