• Comprehensive Care for Bone Marrow Failure Syndromes

    The Bone Marrow Failure Clinic at Cincinnati Children’s Hospital Medical Center provides highly sophisticated and comprehensive multidisciplinary care for children with bone marrow failure syndromes.

    Bone marrow failure happens when your bone marrow no longer makes enough blood cells. It can be caused by something that happens to you during your lifetime (such as chemotherapy) or you can be born with it. A variety of inherited diseases cause bone marrow failure.

    The clinic offers evaluation, diagnosis and treatment for all types of bone marrow failure syndromes. Among the conditions we see are:

  • Conditions Treated

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    This inherited disorder causes the bone marrow to produce too few platelets in the blood. Platelets are needed for blood to clot.

    Periodically, the bone marrow produces low levels of neutrophils, the blood cells needed to fight infections.
    This disease causes the bone marrow to produce too few red blood cells, which are needed to carry oxygen to body tissues. Patients may also have physical abnormalities, such as abnormal thumbs and short stature.
    With this disease, all three types of blood cells are low (those that fight infection, those that carry oxygen and those that help blood to clot). Patients also have abnormally shaped fingernails and toenails, a lacy rash on the face and cheek and white patches in the mouth. 
    This inherited disease causes abnormal platelets, which are responsible for blood clotting.
    The red blood cells cannot use the iron in the body to carry oxygen to the tissues. Iron builds up in red blood cells, and patients may have a hard time breathing and feel weak and fatigued.

    All types of blood cells are low. Patients may have an increased risk of infection, fatigue and shortness of breath and bruise and bleed easily. The disease might be the result of an autoimmune disorder (when the body’s immune system fights itself), but the cause it not known.

    Red blood cells are destroyed in the blood stream because of defects in how they are formed in the marrow.
    Extremely rare disease caused by a deficient enzyme called uroporphyrinogen III cosynthase. Symptoms begin during infancy and sometimes cause anemia in a fetus before birth. 

    This disease affects the pancreas, skeleton and bone marrow. It makes it difficult to absorb nutrients from food and commonly causes low white blood cell counts, making it hard for the body to fight infection.

  • Diagnostic Testing Available

    The care team works closely with the Molecular Genetics Laboratory at Cincinnati Children’s, which offers genetic testing for inherited bone marrow failure syndromes.

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