Bone Marrow Transplantation

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Bone Marrow Transplantation

Comprehensive Care for Bone Marrow Failure Syndromes

The Bone Marrow Failure Clinic at Cincinnati Children’s Hospital Medical Center provides highly sophisticated and comprehensive multidisciplinary care for children with bone marrow failure syndromes.
Bone marrow failure happens when your bone marrow no longer makes enough blood cells. It can be caused by something that happens to you during your lifetime (such as chemotherapy) or you can be born with it. A variety of inherited diseases cause bone marrow failure.
The clinic offers evaluation, diagnosis and treatment for all types of bone marrow failure syndromes. Among the conditions we see are:
Conditions Treated

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+ Congenital amegakaryocytic thrombocytopenia

This inherited disorder causes the bone marrow to produce too few platelets in the blood. Platelets are needed for blood to clot.

+ Cyclic neutropenia

Periodically, the bone marrow produces low levels of neutrophils, the blood cells needed to fight infections.

+ Diamond-Blackfan anemia

This disease causes the bone marrow to produce too few red blood cells, which are needed to carry oxygen to body tissues. Patients may also have physical abnormalities, such as abnormal thumbs and short stature.

+ Dyskeratosis congenita

With this disease, all three types of blood cells are low (those that fight infection, those that carry oxygen and those that help blood to clot). Patients also have abnormally shaped fingernails and toenails, a lacy rash on the face and cheek and white patches in the mouth.

+ Glanzmann’s thrombasthenia

This inherited disease causes abnormal platelets, which are responsible for blood clotting.

+ Hereditary sideroblastic anemia

The red blood cells cannot use the iron in the body to carry oxygen to the tissues. Iron builds up in red blood cells, and patients may have a hard time breathing and feel weak and fatigued.

+ Idiopathic severe aplastic anemia

All types of blood cells are low. Patients may have an increased risk of infection, fatigue and shortness of breath and bruise and bleed easily. The disease might be the result of an autoimmune disorder (when the body’s immune system fights itself), but the cause it not known.

+ Paroxysmal nocturnal hemoglobinuria

Red blood cells are destroyed in the blood stream because of defects in how they are formed in the marrow.

+ Porphyria (especially congenital erythropoietic porphyria)

Extremely rare disease caused by a deficient enzyme called uroporphyrinogen III cosynthase. Symptoms begin during infancy and sometimes cause anemia in a fetus before birth.

+ Shwachman-Diamond syndrome

This disease affects the pancreas, skeleton and bone marrow. It makes it difficult to absorb nutrients from food and commonly causes low white blood cell counts, making it hard for the body to fight infection.

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