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Physicians and researchers at Cincinnati Children’s participate in numerous clinical research projects in hopes of improving the prognosis and quality of life for patients with brain and spinal tumors.
Some studies are sponsored by physicians and researchers at Cincinnati Children’s. Many others are offered at our site through national institutions such as the National Cancer Institute, Children’s Oncology Group and the Collaborative Ependymoma Research Network. Participation in these consortiums provides patients with early access to new anti-cancer therapies.
Current clinical research projects focus on:
One clinical research study of note is a Cincinnati Children’s-based pilot study for patients with newly diagnosed, high-grade gliomas and diffuse intrinsic brain stem gliomas. This study incorporates standard therapy with a promising anti-angiogenic agent that is designed to prevent blood vessel growth to stop the tumor from growing. The study also is asking several important questions regarding the biology of these tumors and the quality of life and functional outcomes of these patients.
Cincinnati Children’s is a major referral center for the national Children’s Oncology Group, the National Cancer Institute’s new Pediatric Phase I Consortium and the new Department of Defense Neurofibromatosis Clinical Consortium.
Cincinnati Children’s is also a member of the Collaborative Ependymoma Research Network (CERN) and is leading some studies through the Pediatric Brain Tumor Consortium. As such, our patients have access to the latest anti-cancer drug development clinical research studies, some of them pioneered right here at Cincinnati Children’s. Many of our physicians serve in leadership roles for these research organizations, further strengthening our link to the latest advances in clinical research and care.
The International Diffuse Intrinsic Pontine Glioma (DIPG) Registry is a collaborative effort by physicians and researchers from North America, Canada, Europe, and Australia to centralize and standardize the collection of clinical data and tumor samples from DIPG patients. Cincinnati Children’s CBDI is home to the North American operations of the Registry. The goal of this effort is to support innovative research and ultimately find a cure for DIPG. You may visit our website for more information.
Learn more about our world-class research on cancer in the Division of Oncology.
Learn more about ongoing research efforts at Cincinnati Children’s, including those specific to brain and spinal tumors.
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