Brain and Spinal Tumor Program

  • Pursuing New Therapies Through Research

    Physicians and researchers at Cincinnati Children’s participate in numerous clinical research projects in hopes of improving the prognosis and quality of life for patients with brain and spinal tumors.

    Some studies are sponsored by physicians and researchers at Cincinnati Children’s. Many others are offered at our site through national institutions such as the National Cancer Institute, Children’s Oncology Group and the Collaborative Ependymoma Research Network. Participation in these consortiums provides patients with early access to new anti-cancer therapies.

    Current clinical research projects focus on:

    • Novel chemotherapy combinations for patients with relapsed or refractory (treatment-resistant) tumors 
    • Anti-angiogenic (tumor blood vessel-targeted) therapy regimens 
    • Targeted small molecule anticancer drugs 
    • High-dose therapy regimens with blood and marrow transplantation 
    • Viral therapy 
    • Quality-of-life issues following treatment

    One clinical research study of note is a Cincinnati Children’s-based pilot study for patients with newly diagnosed, high-grade gliomas and diffuse intrinsic brain stem gliomas. This study incorporates standard therapy with a promising anti-angiogenic agent that is designed to prevent blood vessel growth  to stop the tumor from growing. The study also is asking several important questions regarding the biology of these tumors and the quality of life and functional outcomes of these patients.

    National Referral Center

    Cincinnati Children’s is a major referral center for the national Children’s Oncology Group, the National Cancer Institute’s new Pediatric Phase I Consortium and the new Department of Defense Neurofibromatosis Clinical Consortium.

    Cincinnati Children’s is also a member of the Collaborative Ependymoma Research Network (CERN) and is leading some studies through the Pediatric Brain Tumor Consortium. As such, our patients have access to the latest anti-cancer drug development clinical research studies, some of them pioneered right here at Cincinnati Children’s. Many of our physicians serve in leadership roles for these research organizations, further strengthening our link to the latest advances in clinical research and care.

 
 
  • More Information

    For more information about research at Cincinnati Children's in Brain and Spinal Tumors, contact John Perentesis, MD, Director of Oncology, at john.perentesis@cchmc.org or call 513-636-8241.
 
  • More About Our Research

    Learn more about our world-class research on cancer in the Division of Oncology.

    Read more
 
  • DIPG Registry

    DIPG Registry logo.


    The International Diffuse Intrinsic Pontine Glioma (DIPG) Registry is a collaborative effort by physicians and researchers from North America, Canada, Europe, and Australia to centralize and standardize the collection of clinical data and tumor samples from DIPG patients. Cincinnati Children’s CBDI is home to the North American operations of the Registry. The goal of this effort is to support innovative research and ultimately find a cure for DIPG. You may visit our website for more information.