Brain and Spinal Tumor Program

  • Meet the Team

    The Brain and Spinal Tumors Program is home to specialists with a wide variety of backgrounds and areas of focus. As a team, this diversity makes us better prepared to care for your child’s unique needs. Learn more about our faculty and staff.

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    Medical Director

    A photo of Maryam Fouladi.

    Maryam Fouladi, MD, MSc, FRCPC
    Medical Director, Neuro-Oncology Program

    513-636-4266

    maryam.fouladi@cchmc.org

    Maryam Fouladi, MD, MSc, FRCPC

    Medical Director, Neuro-Oncology Program

    Chair, Pediatric Brain Tumor Consortium Steering Committee

    Cincinnati Children's Principal Investigator, Collaborative Ependymoma Research Network

    Professor, UC Department of Pediatrics

    Phone: 513-636-4266

    Fax: 513-636-3549

    Email: maryam.fouladi@cchmc.org

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    Biography

    Maryam Fouladi, MD, MSc, graduated from the University of Toronto School of Medicine, and completed her pediatric residency and hematology / oncology fellowship training at the Hospital for Sick Children in Toronto, Canada. Dr. Fouladi then completed her neuro-oncology fellowship training at St. Jude Children's Research Hospital, and later completed further training in the molecular pharmacology department at St. Jude before becoming a  neuro-oncology faculty member in 2000. She served as the chair of the Phase I Committee at St. Jude.

    Dr. Fouladi moved to Cincinnati Children's in 2008 to direct the neuro-oncology program. She is currently chair for the CNS Tumor New Agent Committee for the Children’s Oncology Group. She is a member of the steering committee for the COG CNS Tumor Committee as well as the Developmental Therapeutics group at COG, and is a member of the Collaborative Ependymoma Research Network (CERN). She serves as local and national study chair (through CERN, COG and the Pediatric Brain Tumor Consortium) for clinical trials that test new approaches to treat children with very poor prognosis tumors such as high-grade gliomas and diffuse intrinsic pontine gliomas.

    Education and Training

    BS: Human Biology, University of Toronto, Toronto, Canada, 1987. 

    MD: University of Toronto, Toronto, Canada, 1991.

    MSc: Institute of Medical Science, University of Toronto, Toronto, Canada, 2002.

    Publications

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    Scientific Director

    A photo of Qing Richard Lu.

    Qing Richard Lu, PhD
    Scientific Director, Brain Tumor Center

    513-636-7684

    richard.lu@cchmc.org

    Qing Richard Lu, PhD

    Scientific Director, Brain Tumor Center

    Professor, UC Department of Pediatrics

    Phone: 513-636-7684

    Email: richard.lu@cchmc.org

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    Specialties

    Education and Training

    BS: Peking Normal University, Beijing, China, 1988.

    MS: Rutgers University, Piscataway, NJ, 1993.

    PhD: Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ, 1997.

    Postdoctoral Fellow: Dana Farber Cancer Institute, Harvard Medical School, Cambridge, MA, 1997 - 2002.

    Publications

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    Grants

    A Novel Model of Medulloblastoma to Define Cancer Pathways and Molecular Targets. Principal Investigator. National Institutes of Health (NINDS). April 2012 – March 2017. 1R01NS078092.

    Molecular Mechanisms of Oligodendrocyte Differentiation and Myelination. Principal Investigator. National Institutes of Health (NINDS). Sept 2010 – Aug 2015. 1R01NS072427.

    Chromatin Remodeling Control of CNS Myelination and Remyelination. Principal Investigator. National Institutes of Health (NINDS). April 2012 – March 2017. 1R01NS075243-01.

    MicroRNA control of Myelination and Remyelination in the Central Nervous System. Principal Investigator. National Multiple Sclerosis Society. July 2012 – June 2015. RG-4727-A-6-0-1.

    Oncology

    A photo of Lionel Chow.

    Lionel M. L. Chow, MD, PhD
    Member, Cancer Biology and Neural Tumors Program

    513-803-1369

    lionel.chow@cchmc.org

    Lionel M.L. Chow, MD, PhD

    Member, Cancer Biology and Neural Tumors Program

    St. Baldrick’s Foundation Scholar

    Sontag Foundation Distinguished Scientist

    Assistant Professor, UC Department of Pediatrics

    Phone: 513-803-1369

    Fax: 513-636-3549

    Email: lionel.chow@cchmc.org

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    Specialties

    Clinical Interests

    Pediatric neuro-oncology

    Research Interests

    Mouse models for glioma; molecular profiling of tumor mutations; biomarkers of tumor progression; novel therapeutic agents for glioma

    Visit the Chow Lab

    Biography

    Lionel Chow, MD, PhD, received his medical and graduate degrees from McGill University in Montreal, Canada, where his research focused on the regulation of T-lymphocyte signaling by the intracellular tyrosine protein kinases Lck and Csk.

    Following his clinical training in pediatrics and pediatric hematology / oncology at the Hospital for Sick Children in Toronto, Canada, he moved to St. Jude Children’s Research Hospital in Memphis, Tenn., to pursue his research interests.

    Chow's research interests have been centered on glioblastoma multiforme, a particularly devastating form of cancer in adults and children. His work has resulted in the development of a number of novel and robust laboratory models for this disease. Using these models and interfacing with clinical trials in the Neuro-Oncology Program as well as those from national consortia such as the Children's Oncology Group (COG) and the Pediatric Brain Tumor Consortium (PBTC), Chow’s laboratory will continue research in this area with the goals of better understanding the origins of this form of cancer and improving patient outcomes.

    Education and Training

    PhD: McGill University, Montreal, Quebec, Canada, 1996.

    MDCM: McGill University, Montreal, Quebec, Canada, 1997.

    Residency: The Hospital for Sick Children, University of Toronto, Toronto, Canada, 1997-2000.

    Clinical Fellowship: The Hospital for Sick Children, University of Toronto, Toronto, Canada, 2000-2003.

    Postdoctoral Fellowship: St. Jude Children’s Research Hospital, Memphis, TN, 2003-2009.

    Clinical Fellowship: St. Jude Children’s Research Hospital, Memphis TN, 2008-2009.

    Certification: Pediatrics, 2000.

    Publications

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    Grants

    2013 – 2014 Sophie’s Angel Run Foundation
    “Preclinical Testing of Notch and mTor Inhibition in a Mouse Model for High-Grade Glioma” 

    2011 – 2014 St. Baldrick’s Foundation Scholars Award
    "Molecular targeting of pediatric high-grade glioma"

    2011 – 2015 Sontag Foundation Distinguished Scientist Award
    "Molecular targeting of high-grade astrocytoma"

    Trent R. Hummel, MD

    Assistant Professor, UC Department of Pediatrics

    Phone: 513-803-1126

    Fax: 513-636-3549

    Email: trent.hummel@cchmc.org

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    Specialties

    Neuro-oncology; CNS tumors in neurofibromatosis type 1 and 2 research interests: developing novel therapeutics in central nervous system tumors including those with very poor prognosis such as high grade gliomas and diffuse intrinsic pontine gliomas.

    Biography

    Trent R. Hummel, MD, completed his graduate medical training at the University of Cincinnati College of Medicine, residency training in pediatrics at Children's Hospital Medical Center of Akron and pediatric hematology/oncology training at Cincinnati Children's Hospital Medical Center. His current appointment is with the University of Cincinnati and Children's Hospital Medical Center in the capacity of assistant professor of pediatrics.

    Dr. Hummel's clinical and academic interests pertain to children and families affected by central nervous system tumors. He is a member of the Central Nervous System (Brain Tumor) Committee in the Children's Oncology Group (COG) as well as the Cincinnati Children's co-principal investigator for the Pediatric Brain Tumor Consortium (PBTC). Dr. Hummel focuses on developing novel therapeutics to treat children with all central nervous system tumors including those patients with neurofibromatosis type 1 and 2 related CNS tumors and very poor prognosis tumors such as high-grade gliomas and diffuse intrinsic pontine gliomas.

    Education and Training

    BS: Eastern Mennonite University, 1997. 

    MD: University of Cincinnati College of Medicine, 2001.

    Residency: Children’s Hospital Medical Center of Akron, Akron, Ohio, 2004.

    Fellowship: Pediatric Hematology / Oncology, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, 2007; Research Fellow, Division of Experimental Hematology, Cincinnati Children’s Hospital Medical Center, 2008.

    Certification: American Board of Pediatrics, 2004; Pediatrics, 2004. Pediatric Hematology / Oncology, 2011.

    Publications

    View PubMed Publications

    A photo of Dr. Perentesis.

    John P. Perentesis, MD, FAAP
    Director, Division of Oncology and Cancer Programs

    513-636-8241

    john.perentesis@cchmc.org

    A photo of Dr. Perentesis.

    John P. Perentesis, MD, FAAP

    Director, Division of Oncology and Cancer Programs

    Deb Kleisinger Endowed Chair of Novel Cancer Treatments

    Executive Co-Director, Cancer and Blood Diseases Institute

    Director, Leukemia / Lymphoma Program

    Cincinnati Children's Principal Investigator, Children’s Oncology Group (COG)

    Cincinnati Children's Principal Investigator, National Cancer Institute Pediatric Phase 1 Consortium

    Professor, UC Department of Pediatrics

    Phone: 513-636-8241

    Email: john.perentesis@cchmc.org

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    Specialties

    Clinical Interests

    Acute myeloid leukemia; neuroblastoma; PNET / Ewing's sarcoma and osteosarcoma; new anticancer drug development; Phase I clinical trials

    Research Interests

    Molecular etiology and pharmacogenetics of pediatric cancers; Down syndrome-associated leukemia; new anticancer drug development

    Biography

    John P. Perentesis, MD, is a nationally recognized expert in the development of new drugs and molecular therapies for pediatric and young adult cancers and leukemia. His laboratory has developed novel anticancer drugs, and discovered genes important in the growth of normal and malignant cells. His laboratory is also developing the use of tumor and patients genetics research for personalizing therapies. In clinical research, he serves in leadership roles for the National Cancer Institute’s Investigational Drug Steering Committee and the NCI Pediatric Phase I Consortium.

    In 2010, Dr. Perentesis was elected by pediatric oncologists from across the country to the national Executive Committee for the NCI-funded Children’s Oncology Group (COG). The COG is the world's largest, cooperative children's cancer research entity. He also is in leadership efforts in the COG for new therapies for leukemia, and adolescent and young adult cancers.

    Education and Training

    MD: University of Michigan, Ann Arbor, MI, 1980.

    Residency: University of Minnesota Medical School, Minneapolis, MN, 1983.

    Fellowship: University of Minnesota Medical School, Minneapolis, MN, 1986.

    Postdoctoral: University of Minnesota Medical School, Minneapolis, MN, 1986.

    Certification: Pediatrics, 1989; Hematology/Oncology, 1990.

    Publications

    View PubMed Publications

    Grants

    The Children's Oncology Group Chair Grant. Site Principal Investigator. National Institutes of Health. Mar 2008 - Mar 2013. #U10 CA 098543.

    Children's Oncology Group Phase I. Site Principal Investigator. National Institutes of Health. Aug 2002 - Jul 2012. #U01 CA 097452.

    Children's Oncology Group New Publication Committee. National Institutes of Health. Sep 2006 - Jul 2012. #U01 CA 97542 .

    Cincinnati Children's Hyundai Scholar in Childhood Cancer Drug Development. Hyundai Hope on Wheels. Oct 2010 - Oct 2011.

    Neurology

    A photo of Mary Sutton.

    Mary Sutton, MD

    513-636-4222

    Mary Sutton, MD

    Assistant Professor, UC Department of Pediatrics

    Phone: 513-636-4222

    Fax: 513-636-3980

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    Specialties

    Neuro-oncology

    Education and Training

    MD: University of Rochester School of Medicine and Dentistry, Rochester, NY, 1989.

    Residency: Pediatrics, Children's Hospital, Boston, MA.

    Fellowship: Neurology, Children's Hospital, Boston, MA.

    Certification: Pediatrics, 1996; Neurology, 1996.

    Neuroradiology

    A photo of Dr. William Ball.

    William S. Ball, MD
    Neuroradiologist, Department of Radiology and Medical Imaging

    513-636-8574

    juanita.hunter@cchmc.org

    A photo of William Ball.

    William S. Ball, MD

    Neuroradiologist, Department of Radiology and Medical Imaging

    Research Consultant, Department of Radiology and Medical Imaging

    Professor, UC Department of Radiology

    UC Department of Pediatrics, UC Department of Biomedical Engineering

    Phone: 513-636-8574

    Email: juanita.hunter@cchmc.org

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    Specialties

    Pediatric neuroradiology

    Biography

    William Ball, MD, received his undergraduate degree in biochemistry from Louisiana State University. He is a graduate of Tulane Medical School, and is board certified in both pediatrics and radiology with added certification in Neuroradiology. He joined the faculty in Radiology at Cincinnati Children's in 1984, and became chief of section in Pediatric Neuroradiology, a position he held from 1988-2001. 

    In 1991, Dr. Ball developed and created the Imaging Research Center (IRC) at Cincinnati Children's, and served as its director from April 1991-2002. As a researcher, Dr. Ball has contributed over 123 scientific contributions to literature, 11 book chapters and was the editor of a complete text Pediatric Neuroradiology that is still in circulation today. He is currently a tenured professor in biomedical engineering, radiology and pediatrics.

    Dr. Ball became chair of the newly formed Department of Biomedical Engineering (UCBME) at UC in 2001, a position he held until 2008. In 2008, Dr. Ball returned to Cincinnati Children’s Hospital as full-time attending staff neuroradiologist where he continued his research in pediatric cerebrovascular occlusive disease with a focus on Sickle Cell Disease (SCD). He returned to the university in August of 2011 as interim vice-president for research. He retired from the practice of neuroradiology in December of 2012 to become permanent vice-president for research at the University of Cincinnati. He continues his research in pediatric CVD at Cincinnati Children’s Hospital under a multi-institutional grant from NIH in SCD.

    Education and Training

    MD: Tulane University School of Medicine, New Orleans, LA, 1974.

    Residency: Pediatrics, Charity Hospital, Tulane Service, New Orleans, LA, 1977; Pediatrics, Oschner Foundation Hospital, Division of Pediatrics, New Orleans, LA, 1977; Radiology, University of New Mexico School of Medicine, Albuquerque, NM.

    Fellowships: Pediatric Radiology / Pediatric Neuroradiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 1981; Neuroradiology, University of New Mexico Medical Center, Albuquerque, NM.

    Certification: Certification of Added Qualifications Neuroradiology, American Board of Radiology 1999, American Board of Radiology, 1982; American Board of Pediatrics, 1982.
    A photo of Blaise Jones.

    Blaise V. Jones, MD
    Chief, Neuroradiology

    513-636-8574

    blaise.jones@cchmc.org

    Blaise V. Jones, MD

    Chief, Neuroradiology

    Associate Director for Clinical Operations

    Medical Director, MRI

    Professor, UC Department of Radiology

    Phone: 513-636-8574

    Fax: 513-636-1388

    Email: blaise.jones@cchmc.org

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    Specialties

    Pediatric neuroradiology; cerebrovascular disease; neuro-oncology

    Biography

    Blaise V. Jones, MD, completed his undergraduate work at Duke University in 1984 and received his MD from Georgetown University in 1988. Dr. Jones did his radiology residency and neuroradiology fellowship at the University of Cincinnati and a pediatric neuroradiology fellowship at Cincinnati Children's Hospital Medical Center.

    Dr. Jones was an assistant professor of radiology and pediatrics and section chief of MR imaging at the M.S. Hershey Center of the Penn State University School of Medicine before joining the pediatric neuroradiology faculty at Cincinnati Children's.

    He is past president of the American Society for Pediatric Neuroradiology and former chair of the Pediatric Neuroradiology Committee of the Society for Pediatric Radiology. He is an examiner for the American Board of Radiology in Neuroradiology.

    Education and Training

    MD: Georgetown University Medical School, Washington, DC, 1988.

    Residency: University of Cincinnati Medical Center, Cincinnati, OH, 1989-1993. 

    Fellowships: Neuroradiology, University of Cincinnati Medical Center, Cincinnati, OH, 1993-1994; Pediatric Neuroradiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 1994-1995. 

    Certification: Maintenance of Certification in Neuroradiology, American Board of Radiology, 2006; Certificate of Added Qualification in Neuroradiology, American Board of Radiology, 1996; Diagnostic Radiology, American Board of Radiology, 1993; Diplomate, National Board of Medical Examiners, 1989.

    Publications

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    A photo of James Leach.

    James L. Leach, MD
    Neuroradiologist, Department of Radiology and Medical Imaging

    513-636-7591

    james.leach@cchmc.org

    James L. Leach, MD

    Neuroradiologist, Department of Radiology and Medical Imaging

    Associate Professor, UC Department of Radiology

    Phone: 513-636-7591

    Fax: 513-636-8145

    Email: james.leach@cchmc.org

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    Specialties

    Neuroradiology; advanced imaging in epilepsy; multimodal imaging of brain tumors; imaging of stroke; MRI utilization; quality assurance initiatives for neuroradiologic interpretation

    Biography

    James (Jim) Leach, MD, is a neuroradiologist specializing in pediatric neuroradiology at Cincinnati Children's Hospital Medical Center. He grew up in southeastern Ohio and attended Ohio University majoring in zoology with an emphasis on comparative anatomy. He was inducted into the Alpha Omega Alpha honor society as a third-year student.

    After seeing a clinical conference given by Bob Lukin, MD, then chief of neuroradiology at the University of Cincinnati College of Medicine, he decided on radiology as a career. He was chief resident of radiology in 1994, and fellow in neuroradiology from 1995-1997 at the University of Cincinnati.

    After serving as a staff neuroradiologist at the University of Cincinnati, Dr. Leach spent five years in private practice at Margaret Mary Community Hospital in Batesville, Indiana. Dr. Leach returned to the University of Cincinnati in 2003. He was program director for the Radiology Residency Program from 2003-2006. Dr. Leach began his full time career at Cincinnati Children's in September 2007, focusing on pediatric neuroradiology.

    Education and Training

    BS: Ohio University, Athens, 1985.

    MD: University of Cincinnati, Cincinnati, OH, 1990.

    Residency: University Hospital, Cincinnati, OH, 1990 -1994.

    Fellowship: University Hospital, Cincinnati, OH, 1994 -1996.

    Visiting Fellowship: Intensive Introduction to Functional MRI, MGH / MIT / HMS Martinos Center, Charlestown, MA, March 2006.

    Certification: National Board of Medical Examiners, 1990; American Board of Radiology, 1994; Neuroradiology, 1997, 2007.

    Publications

    View PubMed Publications

    Neurosurgery

    A photo of Francesco Mangano.

    Francesco T. Mangano, DO, FACS, FACOS
    Chief, Division of Pediatric Neurosurgery

    513-636-4726

    francesco.mangano@cchmc.org

    Francesco T. Mangano, DO, FACS, FACOS

    Chief, Division of Pediatric Neurosurgery

    Director, Pediatric Epilepsy Surgery Program

    Associate Professor, UC Department of Neurosurgery

    Phone: 513-636-4726

    Fax: 513-636-2808

    Email: francesco.mangano@cchmc.org

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    Specialties

    Biography

    Francesco Mangano joined the Division of Pediatric Neurosurgery at Cincinnati Children's in July 2005, as an associate professor of neurosurgery.

    A graduate of the Philadelphia College of Osteopathic Medicine, Dr. Mangano completed his neurosurgical residency at Long Island Jewish Medical Center in 2004 followed by a fellowship in pediatric neurosurgery at St. Louis Children's Hospital in St. Louis, Missouri.

    Since joining the faculty of the division of pediatric neurosurgery at this Cincinnati Children's Hospital Medical Center, he has been instrumental in developing our nationally renowned Pediatric Epilepsy Program and is director of the Pediatric Epilepsy Surgery Program. This program has already given many children a chance to experience a whole new life with marked reduction in the frequency of their debilitating seizures. After extensive evaluation and state of the art imaging and monitoring of the seizures, surgical intervention in many cases can then be exactly targeted to the source of the seizures. An extensive array of surgical techniques may be offered these patients, which ranges from implantation of a vagal nerve stimulator to resection of one whole side of the brain.

    In addition, he is a co-principal investigator for an NIH-funded multi-institutional research study investigating advanced MRI imaging techniques in children with congenital hydrocephalus. This is only one of his numerous active research projects which have resulted in numerous publications, book chapters and national and international presentations in the fields of epilepsy, diffusion tensor imaging (MRI) of hydrocephalus, traumatic brain injury, and vascular and neoplastic brain lesions. He also has expertise in complex disorders of the spine and spinal cord, including spinal cord tumors, and craniocervical junction.

    Dr. Mangano is a member of the American Society of Pediatric Neurosurgeons. He was board certified in 2008 in Neurological Surgery by the American Osteopathic Board of Surgery.

    Education and Training

    DO: Philadelphia College of Osteopathic Medicine (PCOM), Philadelphia, PA.

    Residency: NYCOM-Long Island, Jewish Medical Center / North Shore University Health System, New Hyde Park, NY.

    Fellowship: Washington University School of Medicine-St. Louis Children's Hospital, St. Louis, MO.

    Board Certification: Neurological Surgery, American Osteopathic Board of Surgery, 2008.

    Publications

    View PubMed Publications
    Doctor Stevenson is a Neurosurgeon at Cincinnati Children's.

    Charles B. Stevenson, MD
    Faculty Neurosurgeon, Division of Pediatric Neurosurgery

    513-636-4726

    charles.stevenson@cchmc.org

    Charles B. Stevenson, MD

    Faculty Neurosurgeon, Division of Pediatric Neurosurgery

    Assistant Professor, UC Department of Neurosurgery

    Phone: 513-636-4726

    Email: charles.stevenson@cchmc.org

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    Specialties

    Clinical Interests

    Brain tumors; spasticity; Chiari malformations; fetal surgery; neurovascular disorders; minimal access surgery

    Research Interests

    Neuro-oncology; epilepsy; spasticity

    Biography

    Charles Stevenson, MD, rejoined the Division of Pediatric Neurosurgery at Cincinnati Children's Hospital Medical Center in July 2010, after having served for one year as staff neurosurgeon at Kosair Children’s Hospital in Louisville, Kentucky. Prior to completing his fellowship in pediatric neurosurgery at Cincinnati Children’s, he received his neurosurgical training at Vanderbilt University in Nashville, Tennessee. During that time, he also completed a two-year research fellowship in neurosurgical oncology. He graduated from medical school at Vanderbilt University in Nashville, Tennesee.

    Dr. Stevenson’s interest, specialized training and research background in neuro-oncology make him uniquely qualified to lead our division in its collaborative efforts with the division of neuro-oncology in the Brain and Spinal Tumor program to treat children with primary and recurrent brain tumors. He is assisted in these efforts by leading-edge technology such as the operating room BrainSUITE™, which creates precise three-dimensional maps of the brain and allows for intraoperative MRI imaging to more safely remove particularly complex and deep-seated tumors. Cincinnati Children’s was the first pediatric hospital in the world to offer this technology.

    In addition, Dr. Stevenson brings expertise in selective dorsal rhizotomy as a treatment for spasticity, which, when added to implantation of baclofen pumps and medical therapy, allows for a wide range of treatment options for patients with spasticity from cerebral palsy or spinal cord injury. He is a member of a multidisciplinary team of specialists that includes neurosurgery, orthopedic surgery, physical medicine and rehabilitation as well as and physical and occupational therapies that offers comprehensive care for children with spasticity.

    Dr. Stevenson is a member of the American Society of Pediatric Neurosurgeons.  He was board certified in 2013 in neurological surgery by the American Board of Neurological Surgeons.

    Education and Training

    MD: Vanderbilt University School of Medicine, Nashville, Tennessee, 2001

    Residency: Neurosurgery, Vanderbilt University Medical Center, Nashville, Tennessee

    Fellowship: Pediatric Neurosurgery, Cincinnati Children's Hospital Medical Center, 2008-09.

    Board Certification: Neurological Surgery, American Board of Neurological Surgeons, 2013.

    Publications

    View PubMed Publications

    Physical Medicine and Rehabilitation

    A photo of David Pruitt, MD.

    David W. Pruitt, MD
    Medical Director, Inpatient Pediatric Rehabilitation Unit

    513-636-7480

    david.pruitt@cchmc.org

    David W. Pruitt, MD

    Medical Director, Inpatient Pediatric Rehabilitation Unit

    Director, Pediatric Rehabilitation Medicine Fellowship

    Assistant Professor, UC Department of Pediatrics

    Phone: 513-636-7480

    Fax: 513-636-7360

    Email: david.pruitt@cchmc.org

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    Specialties

    Inpatient pediatric rehabilitation; child and adolescent spinal cord injury; neuro-oncology and musculoskeletal oncology

    Education and Training

    BS: University of Notre Dame, Notre Dame, IN, 1994.

    MD: Loyola University Stritch School of Medicine, Chicago, IL, 1998.

    Residency: Pediatrics, Cincinnati Children's Hospital Medical Center; Physical Medicine and Rehabilitation, University of Cincinnati, Cincinnati, OH.

    Certification: Pediatric Rehabilitation Medicine, 2007; Physical Medicine and Rehabilitation, 2004.

    Publications

    Endocrinology

    Susan R. Rose, MD

    Professor, UC Department of Pediatrics

    Phone: 513-636-4744

    Email: susan.rose@cchmc.org

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    Specialties

    Clinical

    Neuro-endocrinology; hypothalamic-pituitary injury; growth disorders; puberty disorders; thyroid disorders; late effects of cancer

    Research

    Hypothalamic-pituitary function

    Biography

    Susan Rose is professor in the Division of Endocrinology at Cincinnati Children’s Hospital Medical Center and the University of Cincinnati. She has published over 100 review articles or chapters, and about 100 peer-reviewed articles. These include updating guidelines for care of congenital hypothyroidism and writing the chapter on thyroid for Fanaroff's and Avery's textbooks of neonatology. She’s served on the state newborn screening (NBS) committee in Tennessee. She is involved in long term follow up of newborn screening for CAH and congenital hypothyroidism with Region 4 and with the Federal Workgroup on NBS Standards.

    She has clinical expertise and research interests in hypothalamic pituitary function, thyroid hormone disorders, and in disorders of growth or puberty. She has a special interest in the effects of central nervous system injury on hypothalamic-pituitary function. In addition, she has expertise and experience in evaluating the endocrine conditions associated with congenital bone marrow failure syndromes such as Fanconi anemia, Blackfan Diamond anemia, and Shwachman-Diamond syndrome. In addition, she is evaluating the endocrine consequences of hypothalamic-pituitary injury, including traumatic brain injury and injury from treatments for cancer, as well as comparing the relative efficacy of several treatments for precocious puberty. In this study, she will be developing growth curves specific to Fanconi Anemia, recognizing that healthy children with FA may not grow along the typical growth pattern of other healthy children.

    Education and Training

    MD: Case Western Reserve School of Medicine, 1980.

    MEd: School Psychology, University of Dayton, 1972.

    Residency: The Cleveland Clinic, 1983.

    Fellowship: National Institutes of Health, 1986.

    Certification: Pediatrics, 1985; Pediatric Endocrinology, 1986.

    Publications

    View PubMed Publications

    Meilan M. Rutter, MD

    Assistant Professor, UC Department of Pediatrics

    Phone: 513-636-4744

    Fax: 513-636-7486

    Email: meilan.rutter@cchmc.org

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    Specialties

    Clinical Interests

    Bone health and calcium metabolism; disorders of growth, puberty and sex development; endocrine function in cancer survivors; endocrine function in neuromuscular disorders

    Research Interests

    Insulin-like growth factor-1 (IGF-1) therapy in Duchenne Muscular Dystrophy

    Biography

    Meilan Rutter is board-certified in Pediatrics and Pediatric Endocrinology. She is an Assistant Professor of Pediatrics in the Division of Endocrinology, and joined the faculty of Cincinnati Children's Hospital Medical Center in 2008. Currently, Dr. Rutter is assistant director of the Pediatric Endocrinology Fellowship Program.

    Dr. Rutter received her degrees of Bachelor of Medicine and Bachelor of Surgery (MB, BCh) from the University of Wales College of Medicine. She completed her training in Pediatrics in New Zealand, and was admitted to Fellowship of the Royal Australasian College of Physicians (FRACP) in 1995. She underwent fellowship training in Pediatric Endocrinology at Cincinnati Children's. She completed further pediatric residency training to achieve American Board of Pediatrics specialty and subspecialty board certification.

    Dr. Rutter treats children and adolescents with endocrine disorders and diabetes mellitus. She serves as a consultant for the Neuromuscular Comprehensive Care Center and the Neuro-Oncology program at Cincinnati Children's. Additionally. she is a member of the Disorders of Sex Development interdisciplinary team.

    Education and Training

    MB, BCh: University of Wales College of Medicine, Cardiff, United Kingdom.

    FRACP: Royal Australasian College of Physicians, New Zealand.

    Residency: Auckland Children's Hospital and Dunedin Hospital, New Zealand; Cincinnati Children's, Cincinnati, OH.

    Fellowship: Pediatric Endocrinology, Cincinnati Children's, Cincinnati, OH.

    Certification: General Pediatrics, American Board of Pediatrics, 2002; Pediatric Endocrinology, American Board of Pediatrics, 2003; Pediatrics, Fellowship of the Royal Australasian College of Physicians, 1995.

    Publications

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    Researchers

    A photo of Bruce Aronow.

    Bruce J. Aronow, PhD
    Co-director, Computational Medicine Center

    513-636-0263

    bruce.aronow@cchmc.org

    Bruce J Aronow, PhD

    Co-director, Computational Medicine Center

    Professor, UC Department of Pediatrics

    Phone: 513-636-0263

    Fax: 513-636-2056

    Email: bruce.aronow@cchmc.org

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    Specialties

    Biography

    Dr. Aronow's research is devoted to unraveling both the role and mechanism by which the functional capabilities of the human genome shape human health and our ability to adapt to stressful challenges. His lab is using a variety of available structural and functional genomic and biological systems descriptive data to form models of how biological systems assemble, adapt and become impaired in disease. The lab's overall hypothesis is that by interconnecting as much experimental and observational information as possible, we can gain new insights into the mechanisms by which different biological systems can achieve health or healthy adaptation, or undergo disease processes. More specific, with the co-leadership of Anil Jegga, DVM, the lab is identifying genetic features that control gene expression including cis-elements, trans factors and microRNAs, which normally work together in extended cell, tissue, organ and systems networks to enable development and homeostasis. Alterations of these features can alter phenotypes and increase or decrease disease. Some of the lab's work includes the identification of conserved, diverged and evolved cis-element clusters that are acted on by transcription and chromatin proteins. The lab has developed a Web-based tool called GenomeTraFaC that at present allows discovery of shared cis-elements in conserved non-coding sequences of mice and humans.

    Education and Training

    BS: Chemistry, Stanford University, Stanford, CA, 1976.

    PhD: Biochemistry, University of Kentucky, Lexington, KY, 1986.

    Research Fellowship: Division of Basic Science Research, Cincinnati Children's Research Foundation, Cincinnati, OH, 1986-1989.

    Publications

    View PubMed Publications

    Grants

    CTSA - Enabling Tehnologies: Center for Translational & Molecular Disease. National Institutes of Health. Apr 2009 - Mar 2014.

    Kenneth J. Campbell, PhD

    Professor, UC Department of Pediatrics

    Phone: 513-636-0246

    Fax: 513-636-4317

    Email: kenneth.campbell@cchmc.org

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    Specialties

    Molecular genetic control of mammalian forebrain development

    Education and Training

    MS: University of Toronto, Toronto, Canada, 1990.

    PhD: University of Lund, Lund, Sweden, 1994.

    Postdoctoral Fellow: Skirball Institute, NYU Med Center, 1995-97.

    Publications

    View PubMed Publications

    A photo of Lionel Chow.

    Lionel M. L. Chow, MD, PhD
    Member, Cancer Biology and Neural Tumors Program

    513-803-1369

    lionel.chow@cchmc.org

    Lionel M.L. Chow, MD, PhD

    Member, Cancer Biology and Neural Tumors Program

    St. Baldrick’s Foundation Scholar

    Sontag Foundation Distinguished Scientist

    Assistant Professor, UC Department of Pediatrics

    Phone: 513-803-1369

    Fax: 513-636-3549

    Email: lionel.chow@cchmc.org

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    Specialties

    Clinical Interests

    Pediatric neuro-oncology

    Research Interests

    Mouse models for glioma; molecular profiling of tumor mutations; biomarkers of tumor progression; novel therapeutic agents for glioma

    Visit the Chow Lab

    Biography

    Lionel Chow, MD, PhD, received his medical and graduate degrees from McGill University in Montreal, Canada, where his research focused on the regulation of T-lymphocyte signaling by the intracellular tyrosine protein kinases Lck and Csk.

    Following his clinical training in pediatrics and pediatric hematology / oncology at the Hospital for Sick Children in Toronto, Canada, he moved to St. Jude Children’s Research Hospital in Memphis, Tenn., to pursue his research interests.

    Chow's research interests have been centered on glioblastoma multiforme, a particularly devastating form of cancer in adults and children. His work has resulted in the development of a number of novel and robust laboratory models for this disease. Using these models and interfacing with clinical trials in the Neuro-Oncology Program as well as those from national consortia such as the Children's Oncology Group (COG) and the Pediatric Brain Tumor Consortium (PBTC), Chow’s laboratory will continue research in this area with the goals of better understanding the origins of this form of cancer and improving patient outcomes.

    Education and Training

    PhD: McGill University, Montreal, Quebec, Canada, 1996.

    MDCM: McGill University, Montreal, Quebec, Canada, 1997.

    Residency: The Hospital for Sick Children, University of Toronto, Toronto, Canada, 1997-2000.

    Clinical Fellowship: The Hospital for Sick Children, University of Toronto, Toronto, Canada, 2000-2003.

    Postdoctoral Fellowship: St. Jude Children’s Research Hospital, Memphis, TN, 2003-2009.

    Clinical Fellowship: St. Jude Children’s Research Hospital, Memphis TN, 2008-2009.

    Certification: Pediatrics, 2000.

    Publications

    View PubMed Publications

    Grants

    2013 – 2014 Sophie’s Angel Run Foundation
    “Preclinical Testing of Notch and mTor Inhibition in a Mouse Model for High-Grade Glioma” 

    2011 – 2014 St. Baldrick’s Foundation Scholars Award
    "Molecular targeting of pediatric high-grade glioma"

    2011 – 2015 Sontag Foundation Distinguished Scientist Award
    "Molecular targeting of high-grade astrocytoma"

    A photo of Dr. Biplab Dasgupta.

    Biplab Dasgupta, PhD, MS
    Member, Cancer Biology and Neural Tumors Program

    513-803-1370

    biplab.dasgupta@cchmc.org

    Biplab Dasgupta, PhD, MS

    Member, Cancer Biology and Neural Tumors Program

    Assistant Professor, UC Department of Pediatrics

    Phone: 513-803-1370

    Fax: 513-803-1083

    Email: biplab.dasgupta@cchmc.org

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    Specialties

    Biography

    Biplab Dasgupta, PhD, MS, completed his doctorate in molecular biology and immunology at the Indian Institute of Chemical Biology, Calcutta, and a postdoctoral fellowship at Washington University School of Medicine, Saint Louis. Dr. Dasgupta came to Cincinnati Children's Hospital Medical Center in August 2009 as an assistant professor of pediatrics. He is interested in understanding how neural cell / stem cell metabolic and energy status is linked to cell cycle, lineage commitment, differentiation and tumorigenesis. His other interests include genetic, developmental, post-translational, tissue- and stimuli–specific regulation of the subunits that constitute the AMP kinase complex.

    Education and Training

    PhD: Indian Institute of Chemical Biology, Calcutta, 2003

    Postdoctoral Fellowship:
    Washington University School of Medicine, Saint Louis

    Publications

    View PubMed Publications

    Grants

    Regulation of Forebrain Neurogenesis by the Energy Sensor AMP Kinase. Principal Investigator. National Institute of Neurological Disorders and Stroke (NINDS). July 2012 – June 2017.

    Rachid Drissi, PhD

    Assistant Professor, UC Department of Pediatrics

    Phone: 513-636-4266

    Fax: 513-636-3549

    Email: rachid.drissi@cchmc.org

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    Education and Training

    BS: University of Rouen, France, 1983.

    MS: University of Rouen, France, 1984.

    MS: University of Paris VI, France, 1988.

    PhD: University of Paris VI, France, 1994.

    Publications

    View PubMed Publications
    No photo available

    Masato Nakafuku MD, PhD
    Ohio Eminent Scholar

    513-636-9389

    masato.nakafuku@cchmc.org

    No photo available

    Masato Nakafuku, MD, PhD

    Ohio Eminent Scholar

    Professor, UC Department of Pediatrics

    Phone: 513-636-9389

    Email: masato.nakafuku@cchmc.org

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    Specialties

    Development and regeneration of the central nervous system (CNS); therapeutic strategies for neurological diseases

    Visit the Nakafuku Lab.

    Education and Training

    PhD: Graduate School of Medical Sciences, University of Tokyo, 1988.

    MD: The University of Kanazawa School of Medicine, 1984.

    Publications

    View PubMed Publications

    Dao Pan, PhD

    Associate Professor, UC Department of Pediatrics

    Phone: 513-636-6315

    Fax: 513-636-1330

    Email: Dao.Pan@cchmc.org

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    Specialties

    Hematopoietic stem cells; Mesenchymal stem/progenitor cells; Gene therapy; Human genetics; Translational research; Lysosomal storage diseases

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    Education and Training

    PhD: University of Minnesota, Minneapolis, MN, 1997.

    MS: Peking Normal University, Beijing, China, 1991.

    BS: Peking Normal University, Beijing, China, 1988.

    Publications

    View PubMed Publications

    Grants

    Comprehensive Sickle Cell Center. Co-investigator. National Heart, Lung, and Blood Institute. Apr 2008 - Mar 2013. #U54 HL070871.

    Genetic Therapy for CNS Manifestations in MPS I via BBB-Targeted Protein Delivery. Principal Investigator. National Institute of Neurological Disorders and Stroke. Sep 2008 - Aug 2013. #R01 NS064330.

    Gaucher Disease: Treatment of Neurodegenerative Disease. Principal Investigator. National Institute of Neurological Disorders and Stroke. Sep 2013 - May 2018. #R01 NS086134.

    A photo of Nancy Ratner.

    Nancy Ratner, PhD
    Beatrice C. Lampkin Chair, Cancer Biology

    513-636-9469

    nancy.ratner@cchmc.org

    Nancy Ratner, PhD

    Beatrice C. Lampkin Chair, Cancer Biology

    Program Leader, Cancer and Biology and Neural Tumors Program

    Professor, UC Department of Pediatrics

    Phone: 513-636-9469

    Fax: 513-636-3549

    Email: nancy.ratner@cchmc.org

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    Specialties

    Clinical Interests

    Development of the nervous system; peripheral nerve tumor formation

    Research Interests

    Genetic mutations in tumor suppressor genes

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    Biography

    Nancy Ratner, PhD, is interested in understanding mechanisms of peripheral nerve tumor (neurofibroma) formation in Neurofibromatosis type 1 (NF1), a common inherited disorder in which children are predisposed to cancer of the nervous system, to learning problems, bone disorders, and other cancers. She identified EGFR as a potential therapeutic target in NF1 peripheral nerve tumorigenesis, and has developed cell culture and mouse models of NF1 nerve tumorigenesis. Her laboratory has also used analysis of gene expression to identify critical genes in neurofibroma and their malignant derivatives, MPNST. 

    Dr. Ratner received her bachelor's from Brown University, her doctorate from Indiana University, and was a postdoctoral fellow at Washington University in St. Louis. She was a member of the faculty at the University of Cincinnati from 1987 to 2004. Dr. Ratner is currently a professor in the Department of Pediatrics, Cincinnati Children’s Hospital Medical Center, University of Cincinnati, and the program leader for Cancer Biology and Neural Tumors Program in the Cancer and Blood Diseases Institute where she holds the Beatrice C. Lampkin Endowed chair in cancer biology and serves as PI of the NINDS P50 “Cincinnati Center in NF Research”. 

    Dr. Ratner is an active member of the International Consortium on the Molecular Biology of NF1, NF2, and schwannomatosis and was a member of the advisory board for the National Neurofibromatosis Foundation (now Children’s Tumor Foundation) from 1989 to 2007. She chaired the Department of Defense Neurofibromatosis Research Program Integration Panel in 2008, and currently serves as a member of the James McDonnell Brain Tumor Research Advisory Board. She received the von Recklinghausen Award from the Children’s Tumor Foundation in 2010.

    Education and Training

    PhD: Indiana University, 1982.

    BA: Brown University, 1975.

    Fellowship: Washington University St. Louis, 1982-1987.

    Publications

    View PubMed Publications

    Grants

    Mitogenic Activities in Neurofibromatosis. Principle Investigator. Sept 2011-2016. NIH-R01 NS 28840-20.

    A photo of Jianqiang Wu.

    Jianqiang Wu, MD, MS
    Member, Cancer Biology and Neural Tumors Program

    513-636-0955

    jianqiang.wu@cchmc.org

    Jianqiang Wu, MD, MS

    Member, Cancer Biology and Neural Tumors Program

    Assistant Professor, UC Department of Pediatrics

    Phone: 513-636-0955

    Fax: 513-803-0783

    Email: jianqiang.wu@cchmc.org

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    Specialties

    Preclinical therapeutic trial on neurofibroma; cancer stem cell(s) in neurofibroma

    Education and Training

    MD: Soochow University College of Medicine, SooChow, P.R. China, 1991.

    MS: Soochow University College of Medicine, SooChow, P.R. China, 1996.

    Publications

    View PubMed Publications

    Yutaka Yoshida, PhD

    Assistant Professor, UC Department of Pediatrics

    Phone: 513-803-0943

    Email: yutaka.yoshida@cchmc.org

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    Specialties

    Molecular mechanisms of neural circuit formation in the developing spinal cord.

    Visit the Yoshida Lab.

    Education and Training

    BS: Keio University, 1994.

    PhD: University of Tokyo, 1999.

    Postdoctoral fellow: University of Tokyo, 1999-2002; Columbia University, 2002-2007.

    Publications

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    Grants

    Regulation of Sensory-Motor Connectivity by Semaphorin-Plexin Signaling. Principal Investigator. National Institutes of Health. Apr 2009 - Mar 2014. #R01NS065048.