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Director

Stuart L. Goldstein, MD
Director, Center for Acute Care Nephrology

513-803-3295

stuart.goldstein@cchmc.org

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Stuart L. Goldstein, MD

Director, Center for Acute Care Nephrology

Professor, UC Department of Pediatrics

Phone: 513-803-3295

Fax: 513-636-6407

Email: stuart.goldstein@cchmc.org

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Specialties

Clinical Interests

Acute kidney injury; continuous renal replacement therapy; end-stage renal disease; health-related quality of life

Research Interests

Acute kidney injury epidemiology and biomarkers; health-related quality of life in ESRD; cardiovascular complications and inflammation in ESRD

Biography

Stuart L. Goldstein, MD has been an active investigator in the field of pediatric acute kidney injury (AKI) since 2000. Dr. Goldstein's main research foci include AKI epidemiology and outcomes, acute renal replacement therapy provision and investigation of novel urinary AKI biomarkers in the pediatric population. Dr. Goldstein has a strong record of interdisciplinary and inter-institutional collaboration, evidenced by his establishment and directing of the Prospective Pediatric Continuous Renal Replacement Therapy (ppCRRT) and its success as well as collaboration with critical care physicians, cardiologists and emergency medicine physicians to study AKI in their populations.

This collaboration includes publication of the first article demonstrating the existence of a cardio-renal syndrome in pediatric patients with acute decompensated heart failure. Dr. Goldstein has also performed the only published assessment of novel urinary AKI biomarkers in a heterogeneous group of critically ill children, demonstrating their accuracy to predict AKI development and severity. Dr. Goldstein has been developing a program to investigate and minimize nephrotoxic medication associated AKI in non-critically ill children.

Education and Training

MD: Columbia College of Physicians and Surgeons, New York, NY, 1990.

Residency: Baylor College of Medicine, Houston, TX.

Fellowship: Pediatric Nephrology, Children's Hospital, Boston, MA.

Publications

View PubMed Publications

Goldstein SL, Devarajan P. Acute kidney injury in childhood: should we be worried about progression to CKD? Pediatr Nephrol. 2011 Apr;26(4):509-22.

Du Y, Zappitelli M, Mian A, Bennett M, Ma Q, Devarajan P, Mehta R, Goldstein SL. Urinary biomarkers to detect acute kidney injury in the pediatric emergency center. Pediatr Nephrol. 2011 Feb;26(2):267-74.

Moffett BS, Goldstein SL, Adusei M, Kuzin J, Mohan P, Mott AR. Risk factors for postoperative acute kidney injury in pediatric cardiac surgery patients receiving angiotensin-converting enzyme inhibitors. Pediatr Crit Care Med. 2011 Feb 10.

Zappitelli M, Moffett BS, Hyder A, Goldstein SL. Acute kidney injury in non-critically ill children treated with aminoglycoside antibiotics in a tertiary healthcare centre: a retrospective cohort study. Nephrol Dial Transplant. 2011 Jan;26(1):144-50.

Koralkar R, Ambalavanan N, Levitan EB, McGwin G, Goldstein S, Askenazi D. Acute Kidney Injury Reduces Survival in Very Low Birth Weight Infant. Pediatr Res. 2010 Dec 20.

Goldstein SL. Continuous renal replacement therapy: mechanism of clearance, fluid removal, indications and outcomes. Curr Opin Pediatr. 2010 Dec 21.

Goldstein SL. Urinary kidney injury biomarkers and urine creatinine normalization: a false premise or not? Kidney Int. 2010 Sep;78(5):433-5.

Goldstein SL, Chawla L. Renal Angina. Clin J AmSoc Nephrol. 2010 May;5(5):943-9.

Sutherland SM, Zappitelli M, Alexander SR, Chua AN, Brophy PD, Bunchman TE, Hackbarth R, Somers MJG, Baum M, Symons JM, Flores FX, Benfield M, Askenazi D, Chand D, Fortenberry JD, Mahan JD, McBryde K, Blowey D, Goldstein SL. Fluid Overload and Mortality in Children Receiving Continuous Renal Replacement Therapy: The Prospective Pediatric Continuous Renal Replacement Therapy Registry. Am J Kidney Dis. 2010 Feb;55(2):316-25.

Grants

PlasmaLyte Gastroenteritis Study. Principal Investigator. Baxter Healthcare. Nov 2010 - Oct 2011.

Inflammation, malnutrition and cardiac calcification in pediatric ESRD patients receiving dialysis- a comparison of hemodialysis vs. peritoneal dialysis. Principal Investigator. Baxter Healthcare. Dec 2010 - Dec 2011.

Optimize Fluid Dosing in Critically Ill Children with Acute Kidney Injury. Principal Investigator. Casey Lee Ball Foundation. Jan 2011 – Dec 2011.

Use of NGAL to Optimize Fluid Dosing, CRRT Initiation and Discontinuation in Critically Ill Children with Acute Kidney Injury. Principal Investigator. Casey Lee Ball Foundation. Feb 2011 - Jan 2012.

Evaluation of cystatin C and Urine Proteins as Early Biomarkers of AKI in Children Treated with Nephrotoxic Medication. Principal Investigator. The Research Institute of McGill University Health Centre. Jun 2011 – Jun 2012.

Center for Acute Care Nephrology Fellowship. Fellowship Director. Funded by Gambra Renal Products. Jan 2011 - Jan 2013.

Inflammation, malnutrition and cardiac calcification in pediatric ESRD patients receiving dialysis. Principal Investigator. Casey Lee Ball Foundation. Jan 2010 - Dec 2020.

Faculty

Raj K. Basu, MD
Co-Director, Center for Acute Care Nephrology

513-636-4259

rajit.basu@cchmc.org

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Raj K. Basu, MD

Co-Director, Center for Acute Care Nephrology

Assistant Professor, UC Department of Pediatrics

Phone: 513-636-4259

Fax: 513-636-4267

Email: rajit.basu@cchmc.org

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Specialties

Pediatric Critical Care, Acute kidney injury, ethics/end-of-life care

Biography

Dr. Basu arrived at Cincinnati Children's after completing his residency and fellowship training at Children’s Memorial Hospital in Chicago. The focus of his research efforts thus far have been in increasing the appreciation for the impact of acute kidney injury (AKI) on critical illness. In addition to his research and publication efforts, Dr. Basu has been actively involved in the fellowship program coordinating numerous lectures, an ethics curriculum, and mentoring residents/fellows. He also currently sits on the hospital action committees dedicated to improving the care of status asthmaticus and status epilepticus.

Education and Training

MD: Indiana University, Indianapolis, IN 2003

Residency: Pediatrics, Northwestern University Children’s Memorial Hospital, Chicago, IL, 2003-2006

Fellowship: Pediatric Critical Care, Northwestern University Children’s Memorial Hospital, Chicago, IL, 2006-2009

Certifications: Pediatrics, 2006; Critical Care, 2010

Publications

View PubMed Publications

HR Wong, NZ Cvijanovich, GL Allen, NJ Thomas, RJ Freishtat, N Anas, K Meyer, PA Checchia, R Lin, TP Shanley, MT Bigham, DS Wheeler, LA Doughty, K Tegtmeyer, SE Poynter, JM Kaplan, RS Chima, E Stalets, RK Basu, BM Varisco, and FE Barr. “Validation of a Gene Expression-Based Subclassification Strategy for Pediatric Septic Shock.” Critical Care Medicine, 2011 Jun 23.

Rajit K. Basu, E Donaworth, DS Wheeler, P Devarajan, and HR Wong. “Antecedent acute kidney injury worsens subsequent endotoxin-induced lung inflammation in a 2-hit mouse model.” Am Journ Physio Renal Physiology, 2011 Jun 15.

Rajit K. Basu and Derek Wheeler. “Effects of ischemic acute kidney injury on lung water balance: Nephrogenic pulmonary edema.” Pulmonary Med 2011; 2011.

Rajit K. Basu, DS Wheeler, SL Goldstein, and LA Doughty. “Acute Renal Replacement Therapy in Pediatrics.” International Journal of Nephrology, 2011; 2011: 785392.

Rajit K. Basu, Wong H, Wheeler DS, Devarajan P. “Acute Kidney Injury in Pediatrics, an Update and Review.” Pediatric Crit Care Med, 2011, May; 12(3): 339-47

Rajit K. Basu, S Hubchak, T Hayashida, CE Runyan, PT Schumacker, HW Schnaper^.Interdependence of HIF-1 and TGF- signaling in normoxic and hypoxic renal epithelial cell collagen expression. Am Journ Physio Renal Physiology, Jan 2011, 300: F898-905.

Rajit K. Basu and Derek Wheeler. “Approaches to the management of acute kidney injury in children.” Recent Patents on Biomarkers 2011, 1:49-59.

Hector R. Wong, Derek S. Wheeler, Ken Tegtmeyer, Sue E. Poynter, Jennifer M. Kaplan, Ranjit S. Chima, Erika Stalets, Rajit K. Basu, Lesley A. Doughty. “Toward a clinically feasible gene expression-based subclassification strategy for septic shock: Proof of concept.” Critical Care Med 2010 Oct; 38(10): 1955-61.

Michael R. Bennett, PhD
Director, Biomarker Laboratory

513-636-8349

michael.bennett@cchmc.org

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Michael R. Bennett, PhD

Director, Biomarker Laboratory

Assistant Professor, UC Department of Pediatrics

Phone: 513-636-8349

Email: michael.bennett@cchmc.org

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Specialties

Diagnostic markers for pediatric diseases; acute kidney injury; nephrotic syndrome, lupus nephritis; focal segmental glomerulosclerosis; mechanisms of neurologic disease

Education and Training

Research Fellowship: Cincinnati Children's Hospital Medical Center, Cincinnati, OH

PhD: University of Cincinnati College of Medicine, Cincinnati, OH, 2004.

BA: Thomas More College, Crestview Hills, KY, 1997.

Publications

View PubMed Publications

Krawczeski C, Vandevoorde R, Kathman T, Bennett M, Woo J, Wang Y, Griffiths R, Devarajan P. Serum Cystatin C Is an Early Predictive Biomarker of Acute Kidney Injury after Pediatric Cardiopulmonary Bypass. CJASN. 2010; 2010 Sep;5(9):1552-7.

Bagshaw SM, Bennett M, Haase M, Haase-Fielitz A, Egi M, Morimatsu H, D'amico G, Goldsmith D, Devarajan P, Bellomo R. Plasma and urine neutrophil gelatinase-associated lipocalin in septic versus non-septic acute kidney injury in critical illness. Intensive Care Med. 2009;36(3):381-4

Stella CL, Bennett MR, Devarajan P, Greis K, Wyder M, Macha S, Rao M, Jodicke C, Moussa H, How HY, Myatt L, Webster R, Sibai BM. Preterm labor biomarker discovery in serum using 3 proteomic profiling methodologies. Am J Obstet Gynecol. 2009;201(4):387.e1-13.

Haase M, Bellomo R, Devarajan P, Ma Q, Bennett MR, Möckel M, Matalanis G, Dragun D, Haase-Fielitz A. Novel biomarkers early predict the severity of acute kidney injury after cardiac surgery in adults. Ann Thorac Surg. 2009;88(1):124-30

Haase-Fielitz A, Bellomo R, Devarajan P, Bennett M, Story D, Matalanis G, Frei U, Dragun D, Haase M. The predictive performance of plasma neutrophil gelatinase-associated lipocalin (NGAL) increases with grade of acute kidney injury. Nephrol Dial Transplant. 2009;24:3349-3354.

Bennett M, Ravipati N, Ross G, Nguyen M, Hirsch R, Beekman R, Rovner L, Devarajan P. Using proteomics to identify pre-procedural risk factors for contrast induced nephropathy. Proteomics – Clinical Applications. 2008;2(7-8):1058-1064.

Koyner JL, Bennett MR, Worcester EM, Ma Q, Raman J, Jeevanandam V, Kasza KE, O'Connor MF, Konczal DJ, Trevino S, Devarajan P, Murray PT. Urinary cystatin C as an early biomarker of acute kidney injury following adult cardiothoracic surgery. Kidney Int. 2008;74(8):1059-1069.

Lavery AP, Meinzen-Derr JK, Anderson E, Ma Q, Bennett MR, Devarajan P, Schibler KR. Urinary NGAL in premature infants. Pediatr Res. 2008;64(4):423-8.

Bennett M, Dent C, Ma Q, Dastrala S, Grenier F, Workman R, Syed H, Ali S, Barasch J, Devarajan P. Urine NGAL predicts acute kidney injury, morbidity and mortality after cardiac surgery: a prospective study. Clinical Journal of the American Society of Nephrology. 2008;3(3): 665-673.

Bennett M, Czech K, Arend L, Witte D, Devarajan P, Potter, S. Analysis of the glomerular gene expression profile in patients with focal segmental glomerulosclerosis. Experimental Nephron. 2007;107(1): e30-40

Suzuki M, Ross GF, Wiers K, Nelson S, Bennett MR, Passo MH, Devarajan P, Brunner HI. Identification of a urinary proteomic signature for lupus nephritis. Pediatric Nephrology. 2007;22(12): 2047-2057.

Prasad Devarajan, MD
Louise M. Williams Endowed Chair

513-636-4531

prasad.devarajan@cchmc.org

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Prasad Devarajan, MD

Louise M. Williams Endowed Chair

Director, Nephrology and Hypertension

Professor, UC Department of Pediatrics

Phone: 513-636-4531

Fax: 513-636-7407

Email: prasad.devarajan@cchmc.org

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Specialties

Visit the Devarajan Lab.

Education and Training

Premedical Studies: Bombay University, India, 1979.

MD: Bombay University, India, 1985.

Publications

View PubMed Publications

Czech KA, Bennett M, Devarajan P. Distinct metalloproteinase excretion patterns in focal segmental glomerulosclerosis. Pediatr Nephrol. 2011 Jul 1.

Askenazi DJ, Koralkar R, Levitan EB, Goldstein SL, Devarajan P, Khandrika S, Mehta RL, Ambalavanan N. Baseline Values of Candidate Urine Acute Kidney Injury (AKI) Biomarkers Vary by Gestational Age in Premature Infants. Pediatr Res. 2011 Jun 3.

Abraham BP, Frazier EA, Morrow WR, Blaszak RT, Devarajan P, Mitsnefes M, Bryant JC, Sachdeva R. Cystatin C and neutrophil gelatinase-associated lipocalin as markers of renal function in pediatric heart transplant recipients. Pediatr Transplant. 2011 Apr 25.

Sundaram N, Bennett M, Wilhelm J, Kim MO, Atweh G, Devarajan P, Malik P. Biomarkers for early detection of sickle nephropathy. Am J Hematol. 2011 Jul;86(7):559-66.

Devarajan P, Krawczeski C. In reply to 'antifibrinolytic use during cardiac and hepatic surgery makes tubular proteinuria-based early biomarkers poor tools to diagnose perioperative acute kidney injury'. Am J Kidney Dis. 2011 Jun;57(6):960-1.

Piyaphanee N, Ma Q, Kremen O, Czech K, Greis K, Mitsnefes M, Devarajan P, Bennett MR. Discovery and initial validation of α 1-B glycoprotein fragmentation as a differential urinary biomarker in pediatric steroid-resistant nephrotic syndrome. Proteomics Clin Appl. 2011 Jun;5(5-6):334-42.

Li S, Krawczeski CD, Zappitelli M, Devarajan P, Thiessen-Philbrook H, Coca SG, Kim RW, Parikh CR; for the TRIBE-AKI Consortium. Incidence, risk factors, and outcomes of acute kidney injury after pediatric cardiac surgery: A prospective multicenter study. Crit Care Med. 2011 Jun;39(6):1493-1499.

Krawczeski CD, Woo JG, Wang Y, Bennett MR, Ma Q, Devarajan P. Neutrophil gelatinase-associated lipocalin concentrations predict development of acute kidney injury in neonates and children after cardiopulmonary bypass. J Pediatr. 2011 Jun;158(6):1009-1015.e1.

Basu RK, Devarajan P, Wong H, Wheeler DS. An update and review of acute kidney injury in pediatrics. Pediatr Crit Care Med. 2011 May;12(3):339-47.

Devarajan P. Biomarkers for the early detection of acute kidney injury. Curr Opin Pediatr. 2011 Apr;23(2):194-200.

Grants

Research Training in Pediatric Nephrology 0.6 calendar months. Principal Investigator. National Institute of Diabetes and Digestive and Kidney Diseases. Jul 2007 - Jun 2012.

Biomarkers of renal injury in cardiac surgery 1.2 calendar months. Principal Investigator. National Heart, Lung and Blood Institute. Jul 2007 - Jun 2012.

Long term outcomes of AKI after cardiac surgery 0.6 calendar months. Principal Investigator. National Institute of Diabetes and Digestive and Kidney Diseases. Sep 2008 - Aug 2013.

John Lynn Jefferies, MD, MPH, FAAP, FACC
Director, Advanced Heart Failure and Cardiomyopathy

513-803-3316

john.jefferies@cchmc.org

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John L. Jefferies, MD, MPH, FAAP, FACC

Director, Advanced Heart Failure and Cardiomyopathy

Co-Director, CV Genetics

Associate Director, HIRC

Associate Professor, UC Department of Pediatrics

Phone: 513-803-3316

Email: john.jefferies@cchmc.org

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Specialties

Heritable causes of vascular disease, novel drug therapies for advanced heart failure, novel gene discovery in cardiomyopathy, characterization and management of left ventricular noncompaction (LVNC), and early diagnosis and management of chemotherapy induced cardiotoxicity.

Biography

Dr. Jefferies, an associate professor of Pediatric Cardiology and Adult Cardiovascular Diseases, is the director of Advanced Heart Failure / Cardiomyopathy, director of the Ventricular Assist Device Program, co-director of Cardiovascular Genetics and associate director of the Heart Institute Research Core (HIRC) within the Heart Institute at Cincinnati Children's Hospital Medical Center.

He completed his combined Pediatric and Adult Cardiology training at the Baylor College of Medicine in Houston, Texas at the Texas Children's Hospital and the Texas Heart Institute. He has authored numerous peer-reviewed manuscripts and book chapters on Cardiomyopathy, Cardiovascular Genetics, and Adults with Congenital Heart Disease.

His current research interests include heritable causes of vascular disease, novel drug therapies for advanced heart failure, novel gene discovery in cardiomyopathy, characterization and management of left ventricular noncompaction (LVNC), and early diagnosis and management of chemotherapy induced cardiotoxicity.

He is on the Editorial Board of the Texas Heart Institute Journal and is an active member of numerous professional organization including the Heart Failure Society of America, the American College of Cardiology and the American Heart Association.

Education and Training

BS: University of Tennessee, Knoxville, TN, 1992.

MD: University of Tennessee, Knoxville, TN, 1996.

Residency: University of Kentucky, Lexington, KY, 2000.

MPH: University of Kentucky, Lexington, KY, 2001 Fellowship: Baylor College of Medicine, Houston, TX, 2006.

Certification: Internal Medicine, 2000; Pediatrics, 2001

Publications

View PubMed Publications

Jefferies JL, Towbin JA. Dilated cardiomyopathy. Lancet. 2010 Feb;375(9716):752-62.

Breinholt JP, Moulik M, Dreyer WJ, Denfield SW, Kim JJ, Jefferies JL, Rossano JW, Gates CM, Clunie SK, Bowles KR, Kearney DL, Bowles NE, Towbin JA. Viral epidemiologic shift in inflammatory heart disease: the increasing involvement of parvovirus B19 in the myocardium of pediatric cardiac transplant patients. J Heart Lung Transplant. 2010 Jul;29(7):739-46.

Rossano JW, Morales DL, Zafar F, Denfield SW, Kim JJ, Jefferies JL, Dreyer WJ. Impact of antibodies against human leukocyte antigens on long-term outcome in pediatric heart transplant patients: An analysis of the United Network for Organ Sharing database. J Thorac Cardiovasc Surg. 2010 May 26.

Carlson P, Jefferies JL, Kearney D, Russell H. Refractory dilated cardiomyopathy associated with metastatic neuroblastoma. Pediatr Blood Cancer. 2010 Jun 29.

Shah AM, Jefferies JL, Rossano JW, Decker JA, Cannon BC, Kim JJ. Electrocardiographic abnormalities and arrhythmias are strongly associated with the development of cardiomyopathy in muscular dystrophy. Heart Rhythm. 2010 Jun 18.

Moulik M, Breinholt JP, Dreyer WJ, Kearney DL, Price JF, Clunie SK, Moffett BS, Kim JJ, Rossano JW, Jefferies JL, Bowles KR, O'Brian Smith E, Bowles NE, Denfield SW, Towbin JA. Viral Endomyocardial Infection Is an Independent Predictor and Potentially Treatable Risk Factor for Graft Loss and Coronary Vasculopathy in Pediatric Cardiac Transplant Recipients. J Am Coll Cardiol. 2010 56:582-592.

Shchelochkov OA, Li FY, Wang J, Zhan H, Towbin JA, Jefferies JL, Wong LJ, Scaglia F. Milder Clinical Course of Type IV 3-Methylglutaconic Aciduria Due to a Novel Mutation in TMEM70. Mol Genet Metab. 2010 101:282-285.

Foerster SR, Canter CE, Cinar A, Sleeper LA, Webber SA, Pahl E, Kantor PF, Alvarez JA, Colan SD, Jefferies JL, Lamour JM, Margossian R, Messere JE, Rusconi PG, Shaddy RE, Towbin JA, Wilkinson JD, Lipshultz SE. Ventricular Remodeling and Survival are More Favorable for Myocarditis than for Idiopathic Dilated Cardiomyopathy in Childhood: An Outcomes Study from the Pediatric Cardiomyopathy Registry. Circ Heart Fail. 2010.

Jefferies JL, Price JF, Morales DL. Mechanical support in childhood heart failure. Heart Fail Clin. 2010 Oct;6(4):559-73.

Jefferies JL, Hoffman TM, Nelson DP. Heart failure treatment in the intensive care unit in children. Heart Fail Clin. 2010 Oct;6(4):531-58.

Catherine Dent Krawczeski, MD
Director, Quality Improvement & Clinical Effectiveness

513-801-1801

catherine.krawczeski@cchmc.org

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Catherine Dent Krawczeski, MD

Director, Quality Improvement & Clinical Effectiveness

Co-Director, Center for Acute Care Nephrology

Associate Professor, UC Department of Pediatrics

Phone: 513-801-1801

Fax: 513-636-3952

Email: catherine.krawczeski@cchmc.org

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Specialties

Clinical Interests

Cardiac intensive care; heart failure; heart transplantation; pulmonary hypertension; single ventricle physiology

Research Interests

Acute kidney injury after cardiopulmonary bypass; urinary biomarkers of renal ischemia; intensive care outcomes; cardiopulmonary bypass mediated injury

Biography

Catherine Krawczeski MD is an associate professor of pediatrics with the University of Cincinnati College of Medicine and is clinical faculty in the Cardiac Intensive Care Unit. She is the director of Quality Improvement and Clinical Effectiveness for the Heart Institute and a co-director of the Center for Acute Care Nephrology.

Dr. Krawczeski received her medical degree from the University of Missouri and completed pediatric residency at Washington University/St. Louis Children’s Hospital and fellowships in pediatric cardiology and pediatric critical care medicine at the same institution. She is board certified in both specialties. Dr. Krawczeski has been on staff at Cincinnati Children’s Hospital since 2001.

Dr. Krawczeski focuses her research on clinical outcomes after pediatric cardiac surgery. She has a particular interest in the effects of cardiopulmonary bypass on the kidney. She has had a close collaboration with Prasad Devarajan, director of the division of Nephrology, translating biomarker technology to the bedside for early diagnosis of acute kidney injury (AKI) after cardiopulmonary bypass. Their successful discovery and validation of early AKI biomarkers, such as NGAL, has set the stage for future studies of potential therapeutic interventions. This collaboration has been further strengthened by the recent creation of the Center for Acute Care Nephrology (CACN), a joint effort by the Heart Institute and the division of Nephrology for the purpose of coordinating clinical care and AKI translational and clinical research.

Dr. Krawczeski also has an interest in Quality Improvement. She has been instrumental in creating Heart Institute “dashboards” to track outcomes and determine strategic improvement priorities. She collaborates closely with the Anderson Center to facilitate improvement initiatives within the Heart Institute.

Education and Training

MD: University of Missouri, Kansas City, Missouri, 1991.

Residency: Washington University, St. Louis Children's Hospital, St. Louis, Missouri.

Fellowships: Washington University, St. Louis Children's Hospital, St. Louis, Missouri.

Certification: American Board of Pediatrics 1995, recertification 2002; American Board of Pediatrics, Sub-board of Pediatric Critical Care 2000, recertification 2007; American Board of Pediatrics, Sub-board of Pediatric Cardiology 2002.

Publications

View PubMed Publications

Krawczeski CD, Goldstein SL, Woo, JG, Wang Y, Piyaphanee N, Ma Q, Bennett M, Devarajan P. Temporal relationship and predictive value of urinary acute kidney injury biomarkers after pediatric cardiopulmonary bypass. J Am Coll Cardiol. 2011 Nov 22;58(22):2301-2309.

Zappitelli M, Krawczeski C, Devarajan P, Wang Z, Sint K, Thiessen-Philbrook H, Li S, Bennett M, Ma Q, Shlipak M, Garg A, Parikh C for the TRIBE-AKI Consortium. Early post-operative serum cystatin C predicts severe AKI after pediatric cardiac surgery: a multi-center prospective study. Kidney International. 2011, Sept;80:6555-662.

Parikh CR, Coca SG, Devarajan P, Shlipak MG, Thiessen-Philbrook H, Edelstein CL, Wang Z, Zappitelli M, Koyner J, Krawczeski CD, Patel UD, Swaminathan M, Passik CS, Garg AX; for the TRIBE-AKI Consortium. Post-operative biomarkers predict acute kidney injury and poor outcomes after cardiac surgery. J Am Soc Nephr. 2011, Sept;22:1748-1757.

Parikh CR, Devarajan P, Zappitelli M, Sint K, Thiessen-Philbrook H, Li S, Kim R, Koyner J, Coca SG, Edelstein CL, Shlipak MG, Garg AX, Krawczeski CD; for the TRIBE-AKI Consortium. Early post-operative urine and serum biomarkers predict acute kidney injury and poor outcomes after pediatric cardiac surgery. J Am Soc Nephr. 2011, Sept;22:1737-1747.

Krawczeski CD, Woo JG, Wang Y, Bennett MR, Ma Q, Devarajan P. Neutrophil gelatinase-associated lipocalin concentrations predict development of acute kidney injury in neonates and children after cardiopulmonary bypass. J Pediatr. 2011 Jun;158(6):1009-1015.e1

Haase M, Devarajan P, Haase-Fielitz A, Bellomo R, Cruz DN, Wagener G, Krawczeski CD, Koyner JL, Murray J, Zappitelli M, Goldstein SL, Makris K, Ronco C, Martensson J, Marthing C-R, Venge P, Siew E, Ware LB, Ikizler A, Mertens PR. The outcome of neutrophil gelatinase-associated lipocalin (NGAL)-positive subclinical acute kidney injury: A multi-center pooled analysis of prospective studies. J Am Coll Cardio. 2011 Apr;57:1752-1761

Krawczeski CD, Vandevoorde RG, Kathman T, Bennett MR, Woo JG, Wang Y, Griffiths RE, Devarajan P. Serum cystatin C is an early predictive biomarker of acute kidney injury after pediatric cardiopulmonary bypass. Clin J Am Soc Nephrol. 2010 Sep;5(9):1552-7.

Ohye RG, Sleeper LA, Mahony L, Newburger JW, Pearson GD, Lu M, Goldberg CS, Tabbutt S, Frommelt FC, Ghanayem NS, Laussen PC, Rhodes JF, Lewis AB, Mital S, Ravishankar C, Williams IA, Dunbar-Masterson C, Atz AM, Colan S, Minich LL, Pizarro, C, Kanter KR, Jaggars J, Jacobs J, Krawczeski CD, Pike N, McCrindle BW, Virzi L, Gaynor JW; for the Pediatric Heart Network Investigators. Outcomes of the Norwood procedure in infants randomized to a modified Blalock-Taussig versus right ventricle-to-pulmonary artery shunt. New Engl J Med. 2010 May;362:1980-92.

Dent CL, Ma Q, Dastrala S, Bennett M, Mistnefes M, Barasch J, Devarajan P. Plasma neutrophil gelatinase-associated lipocalin predicts acute kidney injury, morbidity, and mortality after cardiac surgery: a prospective study. Criti Care. 2007 Dec;11(6):R127

Dent CL, Spaeth JP, Jones BV, Schwartz SM, Glauser TA, Hallinan B, Pearl JM, Khoury PR, Kurth CD. Brain magnetic resonance imagining abnormalities following the Norwood procedure using regional cerebral perfusion. J Thorac Cardiovas Surg. 2006 Jan;131(1):190-197.

Grants

Biomarkers of renal injury in cardiac surgery. Co-Investigator. National Heart, Lung, and Blood Institute. Jul 2007 - Jun 2012.

Phase II/III double blind, randomized, placebo controlled, clinical trial to determine the safety and efficacy of intravenous L-citrulline versus placebo in children undergoing cardiopulmonary bypass. Primary Investigator. Asklepion Pharmaceuticals. Feb 2008 - Dec 2012.

Progression of acute kidney injury to chronic kidney disease. Co-Investigator. National Institutes of Health. Jan 2009 - Dec 2013.

Outcomes after single ventricle reconstruction in children with hypoplastic left heart syndrome and other single right ventricle anomalies. Primary Investigator. National Institutes of Health. Jun 2008 - Dec 2015.

David P. Nelson, MD, PhD
Director, Cardiac Intensive Care

513-803-1801

david.nelson@cchmc.org

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David P. Nelson, MD, PhD

Director, Cardiac Intensive Care

Professor, UC Department of Pediatrics

Phone: 513-803-1801

Fax: 513-803-1821

Email: david.nelson@cchmc.org

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Specialties

Clinical Interests

Neurodevelopmental outcomes; family-centered care; cardiopulmonary interactions; physiology of non-conventional circulations; endocrine abnormalities in cardiac intensive care; management of acute decompensated heart failure; cardio-renal syndrome; end of life care

Research Interests

Quality of life and neurodevelopmental outcomes in children with acquired and congenital heart disease; etiology of adrenal dysfunction in cardiac intensive care inflammatory organ system injury after congenital heart surgery

Biography

David P. Nelson, MD, PhD did his Fellowship in Pediatric Critical Care at Harvard University, Boston Children’s Hospital. He served as the Co-Director of the CICU at Texas Children’s Hospital. He joined Cincinnati Children’s Hospital as the Director, Cardiac Intensive Care in 2009.

Dr. Nelson’s clinical interest include Neurodevelopmental outcomes in children with acquired and congenital disease; family-centered care, Cardiopulmonary Interactions and the Physiology of non-conventional circulations; Endocrine abnormalities in Cardiac Intensive Care; Management of Acute Decompensated Heart Failure in children; Cardio-renal syndrome and End of Life Care.

He research focuses on Quality of Life and Neurodevelopmental Outcomes in children with acquired and congenital with acquired and congenital heart disease; Etiology of Adrenal Dysfunction in Cardiac Intensive Care; Inflammatory organ system injury and Congenital Heart Surgery.

Education and Training

PhD: University of Chicago, 1987

MD: University of Chicago Pritzker School of Medicine, 1989.

Residency: University of Washington-Children’s Hospital Medical Center, 1989-1992.

Fellowship: Harvard University, Boston Children’s Hospital, 1992-1994.

Certification: Pediatrics, 1992; Pediatric Cardiology, 1994; Pediatric Critical Care, 1998.

Publications

View PubMed Publications

Moffett BS, McDade E, Rossano JW, Dickerson HA, Nelson DP. Enteral potassium supplementation in a pediatric cardiac intensive care unit: Evaluation of a practice change. Pediatr Crit Care Med. 2011 Feb 3.

Jefferies JL, Hoffman TM, Nelson DP. Heart failure treatment in the intensive care unit in children. Heart Fail Clin. 2010 Oct;6(4):531-58, ix-x. Review.

Carlo WF, Nelson DP. Inhaled nitric oxide improves oxygen saturation in children with pulmonary arteriovenous malformations after the Fontan procedure. Pediatr Crit Care Med. 2010 Aug 5.

Giuliano JS Jr, Lahni PM, Bigham MT, Manning PB, Nelson DP, Wong HR, Wheeler DS. Plasma angiopoietin-2 levels increase in children following cardiopulmonary bypass. Intensive Care Med. 2008 Oct;34(10):1851-7.

Moffet, BS, AR Mott, DP Nelson, KD Gurwitch. Medication dosing and renal insufficiency in a pediatric cardiac intensive care unit: impact of pharmacist consultation. Pediatr Cardiol. 2008 29(4):744-8.

Wheeler DS, Dent CL, Manning PB, Nelson DP. Factors prolonging length of stay in the cardiac intensive care unit following the arterial switch operation. Cardiol Young. 2008 Feb;18(1):41-50.

Price JF, AR Mott, DP Nelson, AC Chang, E O'Brian Smith, JA Towbin, WJ Dreyer, SW Denfield, SL Goldstein. Worsening renal function in children hospitalized with decompensated heart failure: evidence for a pediatric cardiorenal syndrome. Pediatr Crit Care Med. 2008 9(3):279-84.

Moffett, BS, AR Mott, D.P. Nelson, SL Goldstein, JL Jefferies. Renal effects of fenoldopam in critically ill pediatric patients: A retrospective review. Pediatr Crit Care Med. 2008 9(4):403-406.

Rossano JW, MD Taylor, EO Smith, CD Fraser, Jr., ED McKenzie, JF Price, HA Dickerson, DP Nelson, AR Mott. Glycemic profile in infants who have undergone the arterial switch operation: Hyperglycemia is not associated with adverse events. J Thorac Cardiovasc Surg. 2008 135(4):739-45.

Wheeler, DS, CL Dent, PB Manning, DP Nelson. Factors prolonging length of stay in the cardiac intensive care unit following the arterial switch operation. Cardiol Young. 2008 18(1):41-50.

Wheeler, DS, JM Pearl, PB Manning, SM Schwartz, CL Dent, P Khoury, DP Nelson. Factors Prolonging Cardiac Intensive Care Unit Stay after neonatal congenital heart surgery. Pediatr Crit Care Med. 2008 18(1):41-50.

Derek Wheeler, MD, MMM, FAAP, FCCP, FCCM
Attending Physician

513-636-4259

derek.wheeler@cchmc.org

High Res

Derek Wheeler, MD, FAAP, FCCP, FCCM

Attending Physician

Associate Chief of Staff

Associate Professor, UC Department of Pediatrics

Phone: 513-636-4259

Fax: 513-636-4267

Email: derek.wheeler@cchmc.org

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Specialties

Quality improvement and patient safety, high reliability organizations, sepsis and acute kidney injury.

Education and Training

Masters of Medical Management: Carnegie Mellon University, Pittsburgh, PA, 2013.

MD: Indiana University School of Medicine, Indianapolis, IN, 1994.

Intern: Department of Pediatrics, Naval Medical Center, San Diego, CA, 1994-1995.

Residency: Department of Pediatrics, Naval Medical Center, San Diego, CA, 1995-1997.

Fellowship: Division of Critical Care Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2000-2003.

Certification: Diplomate, National Board of Medical Examiners, 1995; Diplomate, American Board of Pediatrics, 1997, 2004; Diplomate, American Board of Pediatrics: Sub-Board of Pediatric Critical Care Medicine, 2004 .

Publications

View PubMed Publications

Wheeler DS, Dunsmore KE, Denenberg AG, Muething L, Poynter SE, Wong HR. Biological activity of truncated C-terminus human heat shock protein 72. Immunol Lett. 2011 Mar 30;135(1-2):173-9

Mack EH, Wheeler DS, Hirsch R. Endovascular treatment of near-fatal neonatal superior vena cava syndrome. Pediatr Crit Care Med. 2010 Nov 24.

Basu RK, Devarajan P, Wong H, Wheeler DS. An update and review of acute kidney injury in pediatrics. Pediatr Crit Care Med. 2010 Nov 4.

Wong HR, Wheeler DS, Tegtmeyer K, Poynter SE, Kaplan JM, Chima RS, Stalets E, Basu RK, Doughty LA. Toward a clinically feasible gene expression-based subclassification strategy for septic shock: proof of concept. Crit Care Med. 2010 Oct;38(10):1955-61.

Istaphanous GK, Wheeler DS, Lisco SJ, Shander A. Red blood cell transfusion in critically ill children: A narrative review. Pediatr Crit Care Med. 2010 May 6.

Nowak JE, Wheeler DS, Harmon KK, Wong HR. Admission chemokine (C-C motif) ligand 4 levels predict survival in pediatric septic shock. Pediatr Crit Care Med. 2010 Mar;11(2):213-6.

Klein JA, Nowak JE, Sutherell JS, Wheeler DS. Nonsurgical management of cardiac missiles. Pediatr Emerg Care. 2010 Jan;26(1):36-8.

Wheeler DS, Chase MA, Senft AP, Poynter SE, Wong HR, Page K. Extracellular Hsp72, an endogenous DAMP, is released by virally infected airway epithelial cells and activates neutrophils via Toll-like receptor (TLR)-4. Respir Res. 2009 Apr 30;10:31.

Wheeler DS. Death to sepsis: targeting apoptosis pathways in sepsis. Crit Care. 2009;13(6):1010.

Mack EH, Wheeler DS, Embi PJ. Clinical decision support systems in the pediatric intensive care unit. Pediatr Crit Care Med. 2009 Jan;10(1):23-8. Review.