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The Center for Acute Care Nephrology, part of the Nephrology and Hypertension Division at Cincinnati Children's, is home to specialists with a wide variety of backgrounds and areas of focus. As a team, this diversity makes us better prepared to care for your child’s unique needs. Learn more about our faculty and staff.
Stuart L. Goldstein, MD Director, Center for Acute Care Nephrology
Director, Center for Acute Care Nephrology
Professor, UC Department of Pediatrics
Acute kidney injury; continuous renal replacement therapy; end-stage renal disease; health-related quality of life
Acute kidney injury epidemiology and biomarkers; health-related quality of life in ESRD; cardiovascular complications and inflammation in ESRD
Stuart L. Goldstein, MD has been an active investigator in
the field of pediatric acute kidney injury (AKI) since 2000. Dr.
Goldstein’s main research foci include: AKI epidemiology and outcomes,
acute renal replacement therapy provision and investigation of novel urinary
AKI biomarkers in the pediatric population.
Dr. Goldstein has established a strong record of interdisciplinary and inter-institutional
collaboration with cardiologists, intensivists and emergency center physicians,
which is evidenced by his establishment and directing of the Prospective
Pediatric Continuous Renal Replacement Therapy Registry from 2001 to 2012, and
the Prospective Pediatric AKI Research Group (ppAKI-RG) in 2012. The ppAKI-RG
is comprised of 39 centers from around the world with the goal of improving
outcomes for the child with or at-risk for, AKI.
Dr. Goldstein has led initial efforts to develop a
standardized definition for pediatric AKI, assess novel AKI biomarkers in
heterogeneous populations, and conceiving and validating stratification tools
to identify patients at risk for AKI. Building
up these findings, Dr. Goldstein embarked on establishing the ppAKI-RG
consortium to focus on multi-centered research studies that are dedicated to
understanding and treating AKI in pediatric patients. Currently, the ppAKI-RG has initiated three
major, and unprecedented, national and international studies (AWARE, NINJA and
DIRECT) to reduce AKI and improve patient outcomes. Dr. Goldstein is also a recognized educator;
he has developed the only pediatric specific Acute Care Nephrology
sub-specialty fellowship with graduates who are now leaders in the field of
Goldstein SL, Devarajan P. Acute kidney injury in childhood: should we be worried about progression to CKD? Pediatr Nephrol. 2011 Apr;26(4):509-22.
Du Y, Zappitelli M, Mian A, Bennett M, Ma Q, Devarajan P, Mehta R, Goldstein SL. Urinary biomarkers to detect acute kidney injury in the pediatric emergency center. Pediatr Nephrol. 2011 Feb;26(2):267-74.
Moffett BS, Goldstein SL, Adusei M, Kuzin J, Mohan P, Mott AR. Risk factors for postoperative acute kidney injury in pediatric cardiac surgery patients receiving angiotensin-converting enzyme inhibitors. Pediatr Crit Care Med. 2011 Feb 10.
Zappitelli M, Moffett BS, Hyder A, Goldstein SL. Acute kidney injury in non-critically ill children treated with aminoglycoside antibiotics in a tertiary healthcare centre: a retrospective cohort study. Nephrol Dial Transplant. 2011 Jan;26(1):144-50.
Koralkar R, Ambalavanan N, Levitan EB, McGwin G, Goldstein S, Askenazi D. Acute Kidney Injury Reduces Survival in Very Low Birth Weight Infant. Pediatr Res. 2010 Dec 20.
Goldstein SL. Continuous renal replacement therapy: mechanism of clearance, fluid removal, indications and outcomes. Curr Opin Pediatr. 2010 Dec 21.
Goldstein SL. Urinary kidney injury biomarkers and urine creatinine normalization: a false premise or not? Kidney Int. 2010 Sep;78(5):433-5.
Goldstein SL, Chawla L. Renal Angina. Clin J AmSoc Nephrol. 2010 May;5(5):943-9.
Sutherland SM, Zappitelli M, Alexander SR, Chua AN, Brophy PD, Bunchman TE, Hackbarth R, Somers MJG, Baum M, Symons JM, Flores FX, Benfield M, Askenazi D, Chand D, Fortenberry JD, Mahan JD, McBryde K, Blowey D, Goldstein SL. Fluid Overload and Mortality in Children Receiving Continuous Renal Replacement Therapy: The Prospective Pediatric Continuous Renal Replacement Therapy Registry. Am J Kidney Dis. 2010 Feb;55(2):316-25.
PlasmaLyte Gastroenteritis Study. Principal Investigator. Baxter Healthcare. Nov 2010 - Oct 2011.
Inflammation, malnutrition and cardiac calcification in pediatric ESRD patients receiving dialysis- a comparison of hemodialysis vs. peritoneal dialysis. Principal Investigator. Baxter Healthcare. Dec 2010 - Dec 2011.
Optimize Fluid Dosing in Critically Ill Children with Acute Kidney Injury. Principal Investigator. Casey Lee Ball Foundation. Jan 2011 – Dec 2011.
Use of NGAL to Optimize Fluid Dosing, CRRT Initiation and Discontinuation in Critically Ill Children with Acute Kidney Injury. Principal Investigator. Casey Lee Ball Foundation. Feb 2011 - Jan 2012.
Evaluation of cystatin C and Urine Proteins as Early Biomarkers of AKI in Children Treated with Nephrotoxic Medication. Principal Investigator. The Research Institute of McGill University Health Centre. Jun 2011 – Jun 2012.
Center for Acute Care Nephrology Fellowship. Fellowship Director. Funded by Gambra Renal Products. Jan 2011 - Jan 2013.
Inflammation, malnutrition and cardiac calcification in pediatric ESRD patients receiving dialysis. Principal Investigator. Casey Lee Ball Foundation. Jan 2010 - Dec 2020.
Raj K. Basu, MD Co-Director, Center for Acute Care Nephrology
Co-Director, Center for Acute Care Nephrology
Assistant Professor, UC Department of Pediatrics
Pediatric critical care; acute kidney injury; ethics/end-of-life care
Dr. Basu arrived at Cincinnati Children's after completing his residency and fellowship training at Children’s Memorial Hospital in Chicago. The focus of his research efforts thus far have been in increasing the appreciation for the impact of acute kidney injury (AKI) on critical illness. In addition to his research and publication efforts, Dr. Basu has been actively involved in the fellowship program coordinating numerous lectures, an ethics curriculum, and mentoring residents/fellows. He also currently sits on the hospital action committees dedicated to improving the care of status asthmaticus and status epilepticus.
Wong HR, Cvijanovich NZ, Allen GL, Thomas NJ, Freishtat RJ, Anas N, Meyer K, Checchia PA, Lin R, Shanley TP, Bigham MT, Wheeler DS, Doughty LA, Tegtmeyer K, Poynter SE, Kaplan JM, Chima RS, Stalets E, Basu RK, Varisco BM, Barr FE. Validation of a gene expression-based subclassification strategy for pediatric septic shock. Critical Care Medicine. 2011 Nov;39(11):2511-7.
Basu RK, Donaworth E, Wheeler DS, Devarajan P, Wong HR. Antecedent acute kidney injury worsens subsequent endotoxin-induced lung inflammation in a 2-hit mouse model. Am Journ Physio Renal Physiology. 2011 Sep;301(3):F597-604.
Basu RK, Wheeler D. Effects of ischemic acute kidney injury on lung water balance: Nephrogenic pulmonary edema. Pulm Med. 2011;2011:414253.
Basu RK, Wheeler DS, Goldstein S, Doughty L. Acute Renal Replacement Therapy in Pediatrics. Int J Nephrol. 2011;2011:785392..
Basu RK, Devarajan P, Wong H, Wheeler DS. An update and review of acute kidney injury in pediatrics. Pediatr Crit Care Med. 2011 May;12(3):339-47.
Basu RK, Hubchak S, Hayashida T, Runyan CE, Schumacker PT, Schnaper HW. Interdependence of HIF-1alpha and TGF-beta/Smad3 signaling in normoxic and hypoxic renal epithelial cell collagen expression. Am J Physiol Renal Physiol. 2011 Apr;300(4):F898-905.
Basu RK, Wheeler DS. Approaches to the management of acute kidney injury in children. Recent Patents on Biomarkers. 2011; 1:49-59.
Wong HR, Wheeler DS, Tegtmeyer K, Poynter SE, Kaplan JM, Chima RS, Stalets E, Basu RK, Doughty LA. Toward a clinically feasible gene expression-based subclassification strategy for septic shock: Proof of concept. Critical Care Med. 2010 Oct; 38(10): 1955-61.
Michael R. Bennett, PhD Director, Biomarker Laboratory
Director, Biomarker Laboratory
David S. Cooper, MD, MPH Director, Cardiac Extracorporeal Life Support Program
Director, Cardiac Extracorporeal Life Support Program
Associate Director, Cardiovascular Intensive Care Unit
MD: University of South Florida College of Medicine, Tampa, Florida, 1996.
MPH: University of South Florida College of Public Health, Tampa, Florida, 1999.
Residency: All Children’s Hospital, University of South Florida, St. Petersburg, FL.
Fellowships: Cardiology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH; Critical Care, Children’s Medical Center Dallas, UT Southwestern, Dallas, Texas.
Certifications: American Board of Pediatrics; American Board of Pediatrics, Sub-board of Pediatric Cardiology; American Board of Pediatrics, Sub-board of Pediatric Critical Care.
Cooper DS, Charpie JR, Flores FX, Gaynor JW, Salvin JW, Devarajan P, Krawczeski CD. Acute kidney injury and critical cardiac disease. World J Ped Congen Heart Surg. 2011;2:411-423. Jacobs JP, Asante-Korang A, O'Brien SM, Chai PJ, Dadlani GH, Rodriguez-Fazzi GL, Vu D, McCormack J, McKenna DE, Boucek RJ Jr, Cooper DS, Saltiel A, Carapellucci J, van Gelder HM, Daicoff GR, Quintessenza JA. Lessons learned from 119 consecutive cardiac transplants for pediatric and congenital heart disease. Ann Thorac Surg. 2011 Apr;91(4):1248-54. Pilchard J, Dadlani G, Andropoulos D, Jacobs JP and Cooper DS. Intensive care and perioperative management of patients with complete atrioventricular septal defect . World J Ped Congen Heart Surg. 2010 Apr;1:105-111.
Scanlon MC, Ghanayem NS, Atz AM, Cooper DS. Innovation in congenital and paediatric cardiac critical care. Cardiol Young. 2009 Nov;19 Suppl 2:85-9. Cooper DS, Costello JM, Bronicki RA, Stock AC, Jacobs JP, Ravishankar C, Dominguez TE, Ghanayem NS. Current challenges in cardiac intensive care: optimal strategies for mechanical ventilation and timing of extubation. Cardiol Young. 2008 Dec;18 Suppl 3:72-83. Cooper DS, Jacobs JP, Chai PJ, Jaggers J, Barach P, Beekman RH, Krogmann O, Manning P. Pulmonary complications associated with the treatment of patients with congenital cardiac disease: consensus definitions from the Multi-Societal Database Committee for Pediatric and Congenital Heart Disease. Cardiol Young. 2008 Dec;18 Suppl 2:215-21. Bacha EA, Cooper D, Thiagarajan R, Franklin RC, Krogmann O, Deal B, Mavroudis C, Shukla A, Yeh T, Barach P, Wessel D, Stellin G, Colan SD. Cardiac complications associated with the treatment of patients with congenital cardiac disease: consensus definitions from the Multi-Societal Database Committee for Pediatric and Congenital Heart Disease. Cardiol Young. 2008 Dec;18 Suppl 2:196-201. Cooper DS, Jacobs JP, Moore L, Stock A, Gaynor JW, Chancy T, Parpard M, Griffin DA, Owens T, Checchia PA, Thiagarajan RR, Spray TL, Ravishankar C. Cardiac extracorporeal life support: state of the art in 2007. Cardiol Young. 2007 Sep;17 Suppl 2:104-15. Cooper, D.S. and Nichter M.A. Advances in cardiac intensive care. Curr Opin Ped. 2006 Oct;18(5):503-11.Cooper DS, Schwartz SM, Raake JL, Beam AR, Nelson DP. Supplemental inhaled gases alter tidal volume delivery and measurement. Pediatr Crit Care Med. 2005 Mar;6(2):150-3.
Prasad Devarajan, MD Director, Division of Nephrology and Hypertension
Director, Division of Nephrology and Hypertension
Medical Director, Stone Center
Director, Nephrology and Hypertension Clinical Laboratory
Louise M. Williams Endowed Chair
Clinical specialties: Acute kidney injury, nephrotic syndrome, kidney stones
Visit the Devarajan Lab.
Czech KA, Bennett M, Devarajan P. Distinct metalloproteinase excretion patterns in focal segmental glomerulosclerosis. Pediatr Nephrol. 2011 Jul 1.
Askenazi DJ, Koralkar R, Levitan EB, Goldstein SL, Devarajan P, Khandrika S, Mehta RL, Ambalavanan N. Baseline Values of Candidate Urine Acute Kidney Injury (AKI) Biomarkers Vary by Gestational Age in Premature Infants. Pediatr Res. 2011 Jun 3. Abraham BP, Frazier EA, Morrow WR, Blaszak RT, Devarajan P, Mitsnefes M, Bryant JC, Sachdeva R. Cystatin C and neutrophil gelatinase-associated lipocalin as markers of renal function in pediatric heart transplant recipients. Pediatr Transplant. 2011 Apr 25. Sundaram N, Bennett M, Wilhelm J, Kim MO, Atweh G, Devarajan P, Malik P. Biomarkers for early detection of sickle nephropathy. Am J Hematol. 2011 Jul;86(7):559-66. Devarajan P, Krawczeski C. In reply to 'antifibrinolytic use during cardiac and hepatic surgery makes tubular proteinuria-based early biomarkers poor tools to diagnose perioperative acute kidney injury'. Am J Kidney Dis. 2011 Jun;57(6):960-1. Piyaphanee N, Ma Q, Kremen O, Czech K, Greis K, Mitsnefes M, Devarajan P, Bennett MR. Discovery and initial validation of α 1-B glycoprotein fragmentation as a differential urinary biomarker in pediatric steroid-resistant nephrotic syndrome. Proteomics Clin Appl. 2011 Jun;5(5-6):334-42.
Li S, Krawczeski CD, Zappitelli M, Devarajan P, Thiessen-Philbrook H, Coca SG, Kim RW, Parikh CR; for the TRIBE-AKI Consortium. Incidence, risk factors, and outcomes of acute kidney injury after pediatric cardiac surgery: A prospective multicenter study. Crit Care Med. 2011 Jun;39(6):1493-1499. Krawczeski CD, Woo JG, Wang Y, Bennett MR, Ma Q, Devarajan P. Neutrophil gelatinase-associated lipocalin concentrations predict development of acute kidney injury in neonates and children after cardiopulmonary bypass. J Pediatr. 2011 Jun;158(6):1009-1015.e1.
Basu RK, Devarajan P, Wong H, Wheeler DS. An update and review of acute kidney injury in pediatrics. Pediatr Crit Care Med. 2011 May;12(3):339-47.
Devarajan P. Biomarkers for the early detection of acute kidney injury. Curr Opin Pediatr. 2011 Apr;23(2):194-200.
John Lynn Jefferies, MD, MPH, FAAP, FACC Director, Advanced Heart Failure and Cardiomyopathy
Director, Advanced Heart Failure and Cardiomyopathy
Associate Professor, UC Department of Pediatrics
Dr. Jefferies, an associate professor of pediatric cardiology and adult cardiovascular diseases, is the director of Advanced Heart Failure / Cardiomyopathy within The Heart Institute at Cincinnati Children's Hospital Medical Center.
He completed his combined pediatric and adult cardiology training at the Baylor College of Medicine in Houston, Texas at the Texas Children's Hospital and the Texas Heart Institute. He has authored or co-authored over 100 peer-reviewed manuscripts and book chapters on cardiomyopathy, cardiovascular genetics, and adults with congenital heart disease.
His current research interests include heritable causes of vascular disease, novel drug therapies for advanced heart failure, novel gene discovery in cardiomyopathy, characterization and management of left ventricular noncompaction (LVNC), and early diagnosis and management of chemotherapy induced cardiotoxicity.
He is on the editorial board of the Texas Heart Institute Journal and is an active member of numerous professional organization including the Heart Failure Society of America, the American College of Cardiology and the American Heart Association.
Jefferies JL, Towbin JA. Dilated cardiomyopathy. Lancet. 2010 Feb;375(9716):752-62. Breinholt JP, Moulik M, Dreyer WJ, Denfield SW, Kim JJ, Jefferies JL, Rossano JW, Gates CM, Clunie SK, Bowles KR, Kearney DL, Bowles NE, Towbin JA. Viral epidemiologic shift in inflammatory heart disease: the increasing involvement of parvovirus B19 in the myocardium of pediatric cardiac transplant patients. J Heart Lung Transplant. 2010 Jul;29(7):739-46. Rossano JW, Morales DL, Zafar F, Denfield SW, Kim JJ, Jefferies JL, Dreyer WJ. Impact of antibodies against human leukocyte antigens on long-term outcome in pediatric heart transplant patients: An analysis of the United Network for Organ Sharing database. J Thorac Cardiovasc Surg. 2010 May 26.
Carlson P, Jefferies JL, Kearney D, Russell H. Refractory dilated cardiomyopathy associated with metastatic neuroblastoma. Pediatr Blood Cancer. 2010 Jun 29.
Shah AM, Jefferies JL, Rossano JW, Decker JA, Cannon BC, Kim JJ. Electrocardiographic abnormalities and arrhythmias are strongly associated with the development of cardiomyopathy in muscular dystrophy. Heart Rhythm. 2010 Jun 18. Moulik M, Breinholt JP, Dreyer WJ, Kearney DL, Price JF, Clunie SK, Moffett BS, Kim JJ, Rossano JW, Jefferies JL, Bowles KR, O'Brian Smith E, Bowles NE, Denfield SW, Towbin JA. Viral Endomyocardial Infection Is an Independent Predictor and Potentially Treatable Risk Factor for Graft Loss and Coronary Vasculopathy in Pediatric Cardiac Transplant Recipients. J Am Coll Cardiol. 2010 56:582-592.Shchelochkov OA, Li FY, Wang J, Zhan H, Towbin JA, Jefferies JL, Wong LJ, Scaglia F. Milder Clinical Course of Type IV 3-Methylglutaconic Aciduria Due to a Novel Mutation in TMEM70. Mol Genet Metab. 2010 101:282-285. Foerster SR, Canter CE, Cinar A, Sleeper LA, Webber SA, Pahl E, Kantor PF, Alvarez JA, Colan SD, Jefferies JL, Lamour JM, Margossian R, Messere JE, Rusconi PG, Shaddy RE, Towbin JA, Wilkinson JD, Lipshultz SE. Ventricular Remodeling and Survival are More Favorable for Myocarditis than for Idiopathic Dilated Cardiomyopathy in Childhood: An Outcomes Study from the Pediatric Cardiomyopathy Registry. Circ Heart Fail. 2010. Jefferies JL, Price JF, Morales DL. Mechanical support in childhood heart failure. Heart Fail Clin. 2010 Oct;6(4):559-73. Jefferies JL, Hoffman TM, Nelson DP. Heart failure treatment in the intensive care unit in children. Heart Fail Clin. 2010 Oct;6(4):531-58.
David P. Nelson, MD, PhD Director, Cardiac Intensive Care
Director, Cardiac Intensive Care
Neurodevelopmental outcomes; family-centered care; cardiopulmonary interactions; physiology of non-conventional circulations; endocrine abnormalities in cardiac intensive care; management of acute decompensated heart failure; cardio-renal syndrome; end of life care
Quality of life and neurodevelopmental outcomes in children with acquired and congenital heart disease; etiology of adrenal dysfunction in cardiac intensive care; inflammatory organ system injury after congenital heart surgery
David P. Nelson, MD, PhD, completed his Fellowship in Pediatric Critical Care at Harvard University, Boston Children’s Hospital. He served as the co-director of Cardiac Intensive Care at Cincinnati Children’s Hospital Medical Center (CCHMC) from July 1996 to August 2005. In September of 2005, Dr. Nelson served as the director of Cardiac Intensive Care at Texas Children’s Hospital for four years before rejoining CCHMC as the director of Cardiac Intensive Care in 2009.
Dr. Nelson’s clinical interests include neurodevelopmental outcomes in children with acquired and congenital disease; family-centered care; cardiopulmonary interactions and the physiology of non-conventional circulations; endocrine abnormalities in cardiac intensive care; management of acute decompensated heart failure in children; cardio-renal syndrome and end of life care.
His research focuses on quality of life and neurodevelopmental outcomes in children with acquired and congenital heart disease; etiology of adrenal dysfunction in cardiac intensive care; inflammatory organ system injury and congenital heart surgery.
Moffett BS, McDade E, Rossano JW, Dickerson HA, Nelson DP. Enteral potassium supplementation in a pediatric cardiac intensive care unit: Evaluation of a practice change. Pediatr Crit Care Med. 2011 Feb 3.
Jefferies JL, Hoffman TM, Nelson DP. Heart failure treatment in the intensive care unit in children. Heart Fail Clin. 2010 Oct;6(4):531-58, ix-x. Review.
Carlo WF, Nelson DP. Inhaled nitric oxide improves oxygen saturation in children with pulmonary arteriovenous malformations after the Fontan procedure. Pediatr Crit Care Med. 2010 Aug 5.
Giuliano JS Jr, Lahni PM, Bigham MT, Manning PB, Nelson DP, Wong HR, Wheeler DS. Plasma angiopoietin-2 levels increase in children following cardiopulmonary bypass. Intensive Care Med. 2008 Oct;34(10):1851-7.
Moffet, BS, AR Mott, DP Nelson, KD Gurwitch. Medication dosing and renal insufficiency in a pediatric cardiac intensive care unit: impact of pharmacist consultation. Pediatr Cardiol. 2008 29(4):744-8.
Wheeler DS, Dent CL, Manning PB, Nelson DP. Factors prolonging length of stay in the cardiac intensive care unit following the arterial switch operation. Cardiol Young. 2008 Feb;18(1):41-50.
Price JF, AR Mott, DP Nelson, AC Chang, E O'Brian Smith, JA Towbin, WJ Dreyer, SW Denfield, SL Goldstein. Worsening renal function in children hospitalized with decompensated heart failure: evidence for a pediatric cardiorenal syndrome. Pediatr Crit Care Med. 2008 9(3):279-84.
Moffett, BS, AR Mott, D.P. Nelson, SL Goldstein, JL Jefferies. Renal effects of fenoldopam in critically ill pediatric patients: A retrospective review. Pediatr Crit Care Med. 2008 9(4):403-406.
Rossano JW, MD Taylor, EO Smith, CD Fraser, Jr., ED McKenzie, JF Price, HA Dickerson, DP Nelson, AR Mott. Glycemic profile in infants who have undergone the arterial switch operation: Hyperglycemia is not associated with adverse events. J Thorac Cardiovasc Surg. 2008 135(4):739-45.
Wheeler, DS, CL Dent, PB Manning, DP Nelson. Factors prolonging length of stay in the cardiac intensive care unit following the arterial switch operation. Cardiol Young. 2008 18(1):41-50.
Wheeler, DS, JM Pearl, PB Manning, SM Schwartz, CL Dent, P Khoury, DP Nelson. Factors Prolonging Cardiac Intensive Care Unit Stay after neonatal congenital heart surgery. Pediatr Crit Care Med. 2008 18(1):41-50.
Ahmad Kaddourah, MD Clinical Fellow, Division of Nephrology and Hypertension
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