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The Diagnostic Immunology Laboratories (DIL), consisting of the Clinical Immunology Laboratory and the Research Immunology Laboratory, are committed to providing the highest quality, comprehensive clinical testing available to aid in the detection, diagnosis and treatment of pediatric oncologic, hematologic and immunologic disorders. We're committed to applying scientific advances to promote efficiency, enhance patient care and improve clinical utility.
Our testing is developed to assist in diagnosis and management of rare primary immunodeficiencies and other disorders of the immune system. Hemophagocytic lymphohistiocytosis (HLH) is a disorder of widespread accumulation of lymphocytes and mature macrophages, sometimes with hemophagocytosis, primarily involving the spleen, lymph nodes, bone marrow, liver and cerebral spinal fluid. HLH can either occur sporadically (secondary HLH), or can be inherited as the autosomal recessive condition known as familial hemophagocytic lymphohistiocytosis (FHL). We also offer clinical testing for Wiskott-Aldrich syndrome (WAS), severe combined immunodeficiency (SCID), X-linked lymphoproliferative disease (XLP) and X-linked immune dysregulation, polyendocrinopathy, enteropathy syndrome (IPEX).
The Clinical Immunology and Research Immunology Laboratories are integrated in a comprehensive Immunodeficiencies and Histiocytosis Program at Cincinnati Children's Hospital Medical Center. It interfaces with the Molecular Genetics Laboratory as part of the Diagnostic Center for Heritable Immunodeficiencies, as well as with the Bone Marrow Transplantation Program.
Our revised B-cell panel includes new markers such as CD20 and IgM / IgD to classify memory B cells as non-switched or switched memory cells. This flow cytometric B-cell panel, using a combination of conjugated monoclonal antibodies, is intended to provide a global overview of B-cell development and differentiation.
Using specific combinations of surface markers, its goal is to detect defects in the normal sequence of maturation and differentiation through the absence of certain subpopulations, and / or the presence of unusual populations (e.g., transitional B cells) not normally found in peripheral blood.
In addition, aberrant B-cell function may be detected by alterations in the normal distribution of B-cell populations, including plasma-blasts. In conjunction with other laboratory data, as well as clinical information, this assay can assist in providing a more detailed picture of the B-cell compartment and its context with the overall immune system.
Search all tests offered by the Clinical Laboratories at Cincinnati Children's.
To request testing, download our test requisition form (.pdf).
To help calculate the volume of blood to draw, download this chart (.pdf).
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