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Family Update is a biweekly newsletter we hope families visiting the Cancer and Blood Diseases Institute can use. This newsletter is our opportunity to share with you stories about the exciting work of our cancer scientists, advances in medical care, and our heroes and supporters. Family Update also contains information about upcoming community events, as well as events and activities here at the hospital for our patients, their families and friends. You can also find out who the current fellows and attending physicians are.
Mohammad Azam, PhD, a researcher in the Cancer and Blood Diseases Institute, has received a grant from CancerFree KIDS to identify new treatments for relapsed childhood leukemia. His research will focus on acute lymphoblastic leukemia (ALL) but it is expected that the findings will be useful for other leukemias and solid tumors as well.In previous research on relapsed cancers, Dr. Azam and colleagues focused on cancer stem cells that remained after treatment. They discovered that two cancer stem cell genes in particular (c-Fos and MKP1) have a critical role in relapsed cancer.Dr. Azam’s new research project will take two approaches. The first approach will test whether the deletion of these genes interferes with leukemia development, using special mouse models that he has constructed in the lab. The second approach will involve targeting c-Fos, MKP1 and other cancer genes using a combination of “small molecule inhibitors” that could eventually lead to the development of specific drugs for use in the clinic.The goal of Dr. Azam’s research is to find a cure for childhood leukemia including prevention of relapse.
Read our most recent issue, published in portable document format (PDF).
The Family Support Network at Cincinnati Children’s supports the quality of life for children and families experiencing cancer, a blood disease or immune disorder.
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