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Meet the team members of the Heart Institute's Cardiology Clinic at Cincinnati Children's Hospital Medical Center.
Thomas R. Kimball, MD Medical Director, Heart Institute
Medical Director, Heart Institute
Professor, UC Department of Pediatrics
Congential heart disease; echocardiography; cardiac imaging
Ventricular function; transgenic mice phenotyping; cardiovascular changes with obstructive sleep apnea; cardiovascular changes with renal disease; pediatric obesity; cardiovascular changes in fit and unfit children; echocardiography quality assurance
Thomas R. Kimball, MD, is a professor of pediatrics with the University of Cincinnati College of Medicine and is currently the medical director of the Heart Institute at Cincinnati Children's Hospital Medical Center.
A native of California, Dr. Kimball graduated with Distinction and Honors from Stanford University. He earned his medical degree from New York University, New York, NY. He completed his pediatric internship and residency at Children's Hospital of Los Angeles and his pediatric cardiology fellowship at Cincinnati Children's Hospital Medical Center.
Dr. Kimball has been an attending staff member of the Division of Cardiology at Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine since 1988.
Dr. Kimball's academic interests relate to echocardiography and he has made numerous scholarly contributions in the field of ventricular function utilizing echocardiography, particularly in the field of hypertension and obesity.
He has established collaborative relationships with basic scientists at the University of Cincinnati College of Medicine using echocardiography to evaluate phenotypes of transgenic mice, including embryonic mice.
Dr. Kimball has been active in the cardiology community. He is a member of the American Society of Echocardiography, American Heart Association, American Academy of Pediatrics, American College of Cardiology and an investigator in the NIH Pediatric Heart Network. He was also a member of the first Family Advisory Council at Cincinnati Children's and received the 2006 Family Advisory Council Award of Excellence. In 2010, he was made the medical director of the Heart Institute at Cincinnati Children's.
Shah AS, Urbina EM, Khoury PR, Kimball TR. Lipids and lipoprotein ratios: The contribution to carotid intima media thickness in adolescents and young adults with type 2 diabetes mellitus. J Clin Lipidol. 2013 Sep-Oct;7(5):441-5.
Uzark K, King E, Spicer R, Beekman R, Kimball T, Varni JW. The clinical utility of health-related quality of life assessment in pediatric cardiology outpatient practice. Congenit Heart Dis. 2013 May;8(3):211-8.
Potts JE, Alghamdi M, De Souza AM, White CT, Potts MT, Warady BA, Furth SL, Sandor GG, Kimball TR. Echo-Doppler assessment of the biophysical properties of the aorta in children with chronic kidney disease. Pediatr Cardiol. 2013 Jun;34(5):1218-25.
Madueme PC, Khoury PR, Urbina EM, Kimball TR. Predictors of exaggerated exercise-induced systolic blood pressures in young patients after coarctation repair. Cardiol Young. 2013 Jun;23(3):416-22.
Urbina EM, Khoury PR, McCoy CE, Dolan LM, Daniels SR, Kimball TR. Triglyceride to HDL-C ratio and increased arterial stiffness in children, adolescents and young adults. Pediatrics. 2013 April;131(4):E1082-90.
Edwards NM, Daniels SR, Claytor RP, Khoury PR, Dolan LM, Kimball TR, Urbina EM. Physical activity is independently associated with multiple measures of arterial stiffness in adolescents and young adults. Metabolism. 2012 Jun;61(6)869-72.
Shah AS, Dolan LM, Gao Z, Kimball TR, Urbina EM. Racial differences in arterial stiffness among adolescents and young adults with type 2 diabetes. Pediatr Diabetes. 2012 Mar;13(2):170-5.
Urbina EM, Khoury PR, McCoy C, Daniels SR, Kimball TR, Dolan LM. Cardiac and vascular consequences of pre-hypertension in youth. J Clin Hypertens. 2011 May;13(5)332-42.
Crowley DI, Khoury PR, Urbina EM, Ippisch HM, Kimball TR. Cardiovascular impact of pediatric obesity epidemic: higher left ventricular mass related to higher body mass index. J Pediatr. 2011 May;158(5):709-14.
Urbina EM, Dolan LM, McCoy CE, Khoury PR, Daniels SR, Kimball TR. Relationship between elevated arterial stiffness and increased left ventricular mass in adolescents and young adults. J Pediatr. 2011 May;158(5)715-21.
Ryan D. Alexy, MD Interventional Cardiology Fellow, Heart Institute
Interventional Cardiology Fellow, Heart Institute
MD: Indiana University School of Medicine, Indianapolis, IN.
Residency: Pediatrics, University of California, Los Angeles, CA, 2009.
Fellowship: Pediatric Cardiology, University of California, Los Angeles, CA, 2013.
Certification: Pediatrics, 2009.
Robert H. Beekman, III, MD
Cardiac catheterization; intervention for congenital heart disease; quality improvement
Robert H. Beekman, III, MD, is currently a professor of pediatric cardiology at Children's Hospital Medical Center of Cincinnati, Ohio. Dr. Beekman's subspecialty interests involve cardiac catheterization and interventional cardiology, and clinical quality improvement.
A native of California, Dr. Beekman graduated from Occidental College in Los Angeles, and earned his MD from Duke University in Durham, NC. Dr. Beekman completed his pediatric internship and residency at UCLA Medical Center, and his pediatric cardiology fellowship at the University of Michigan Medical Center, Ann Arbor, MI. Dr. Beekman also obtained a master's degree in statistical analysis and research design from the University of Michigan. From 1985 to 1996, Dr. Beekman was a member of the Division of Pediatric Cardiology at the University of Michigan School of Medicine. From 1996-2006 he was director of Cardiology at Children's Hospital Medical Center of Cincinnati, and professor of pediatrics at the University of Cincinnati School of Medicine.
Dr. Beekman's academic interests relate to cardiac catheterization, and he has made numerous scholarly contributions in the field of hemodynamic assessment and transcatheter intervention for congenital heart disease. He has published more than 170 manuscripts in cardiology journals.
Dr. Beekman has been active in the cardiology community, locally and nationally. He is chair of the Section on Cardiology and Cardiac Surgery of the American Academy of Pediatrics. Beekman also is the Chair of the JCCHD National Quality Improvement Collaborative for pediatric cardiology. Dr. Beekman has been a member of the Executive Committee and the Training Committee of the AHA Council on Cardiovascular Disease in the Young, and of the Congenital Heart Committee of the ACC. He is currently on the editorial board of the Journal of Interventional Cardiology, a contributing editor of theHeart.org, an Internet cardiology journal, and an associate editor of Congenital Heart Disease.
MD: Duke University School of Medicine, Durham, NC, 1976.
MS: Clinical Research Design and Statistics, University of Michigan, Ann Arbor, MI, 1986.Residency: Pediatrics, UCLA Medical Center, Los Angeles, CA, 1976 to 1979.Fellowship: Pediatric Cardiology, CS Mott Children's Hospital, University of Michigan, Ann Arbor, MI, 1979 to 1982.Certification: Pediatrics, 1981; Pediatric Cardiology, 1983.
Anderson JB, Beekman RH 3rd, Eghtesady P, Kalkwarf HJ, Uzark K, Kehl JE, Marino BS. Predictors of poor weight gain in infants with a single ventricle. J Pediatr. 2010 Sep;157(3):407-13, 413.e1. Sutherell JS, Hirsch R, Beekman RH 3rd. Pediatric interventional cardiology in the United States is dependent on the off-label use of medical devices. Congenit Heart Dis. 2010 Jan;5(1):2-7.
Anderson JB, Beekman RH 3rd, Border WL, Kalkwarf HJ, Khoury PR, Uzark K, Eghtesady P, Marino BS. Lower weight-for-age z score adversely affects hospital length of stay after the bidirectional Glenn procedure in 100 infants with a single ventricle. J Thorac Cardiovasc Surg. 2009 Aug;138(2):397-404.e1. Beekman RH 3rd, Duncan BW, Hagler DJ, Jones TK, Kugler JD, Moore JW, Jenkins KJ; Workgroup on Pediatric Cardiac Devices, Section on Cardiology and Cardiac Surgery, American Academy of Pediatrics. Pathways to approval of pediatric cardiac devices in the United States: challenges and solutions. Pediatrics. 2009 Jul;124(1):e155-62. Bennett MR, Ravipati N, Ross G, Nguyen MT, Hirsch R, Beekman RH, Rovner L, Devarajan P. Using proteomics to identify preprocedural risk factors for contrast induced nephropathy. Proteomics Clin Appl. 2008;2(7-8):1058-1064.
Cooper DS, Jacobs JP, Chai PJ, Jaggers J, Barach P, Beekman RH, Krogman O, Manning P. Pulmonary complications associated with the treatment of patients with congenital heart disease: Consensus definitions from the Multi-Societal Database Committee for Pediatric and Congenital Heart Disease. Cardiology in the Young. 2008;18:215-221.
Jenkins KJ, Beekman RH, Bergersen LJ, Everett AD, Forbes TJ, Franklin RCG, Klitzner TS, Krogman ON, Martin GR, Webb CL. Databases for assessing the outcomes of the treatment of patients with congenital and paediatric cardiac disease: The perspective of cardiology. Cardiology in the Young. 2008;18:116-123, 2008.
Mays WA, Border WL, Knecht SK, Gerdes YM, Pfriem H, Claytor RP, Knilans TK, Hirsch R, Mone SM, Beekman RH. Exercise capacity improves after transcatheter closure of the Fontan fenestration in children. Congenital Heart Disease. 2008;3: 254-261.
Gudausky TM, Hirsch R, Khoury PR, Beekman RH: Comparison of two transcatheter device strategies for occlusion of the patent ductus arteriosus. Catheter Cardiovasc Interven. 2008;72: 675-680.
Gruenstein DH, Beekman RH, Spicer RL Ductal stent and cavo-atrial sac occlusion in an adult with profound cyanosis after palliated cyanotic congenital heart disease. residual superior vena caval-right atrial shunt in an adult with palliated complex congenital heart disease. J Invasive Cardiol. 2008;20: E41-43.
Jonathan W. Byrnes, MD Attending Cardiac Intensivist, Cardiac Intensive Care Unit
Attending Cardiac Intensivist, Cardiac Intensive Care Unit
Assistant Professor, UC Department of Pediatrics
Jonathan Byrnes, MD, is an assistant professor of pediatrics with the University of Cincinnati College of Medicine and an attending cardiac intensivist in Cincinnati Children’s Hospital Medical Center’s Cardiac Intensive Care Unit. He joined the faculty in July 2013.
A native of Mississippi, Dr. Byrnes graduated with Honors from University of Mississippi and earned his medical degree from University of Mississippi Medical Center in 2005. He completed his pediatric residency at Blair Batson Children's Hospital in Jackson, MS and a combined fellowship in cardiology and critical care medicine at Arkansas Children's Hospital. Dr. Byrnes’s clinical interests are providing superb, cost-effective care and delivering cohesive management amongst all specialties in the cardiac intensive care unit.
Dr. Byrnes is active in clinical and translational research involving extracorporeal life support that would benefit critically ill children. This research is primarily focused on the biocompatibility of the patient / device interface and the associated interaction of the coagulation and inflammatory pathways. The aim of these endeavors is to ultimately decrease the incidence of end organ dysfunction and stroke associated with these therapies.
MD: University of Mississippi Medical Center, Jackson, MS, 2005.
Residency: Pediatrics, University of Mississippi Medical Center, Jackson, MS, 2008.
Fellowships: Combined Pediatric Cardiology and Pediatric Critical Care Medicine, Arkansas Children's Hospital, University of Arkansas Medical Sciences, Little Rock, AR, 2013.
Certification: American Board of Pediatrics, 2008.
Prodhan P, Imamura M, Garcia X, Byrnes J, Bhutta A, Dyamenahalli U. Abdominal Compartment Syndrome in Newborns and Children supported on Extracorporeal Membrane Oxygenation. ASAIO J. 2012;58(2): 143-147.
Byrnes J, Williams B, Prodhan P, Erdem E, Williamson R, Gautam N, James C, Jaquiss R, Imamura M, Bhutta A. Successful intra-arterial thrombolytic therapy for a right middle cerebral artery stroke in a 2-year old supported by a ventricular assist device. Transpl Int. 2012;25(3): e31-33.
Byrnes J, W McKamie, C Swearingen, Gossett J, Prodhan P, Bhutta A, Jaquiss R, Imamura M, Fiser R. Hemolysis during Cardiac Extracorporeal Membrane Oxygenation: A Case-Control Comparison of a Roller Pump and a Centrifugal Pump in a Pediatric Population. ASAIO J. 2011 Sep-Oct;57(5):456-61.
Byrnes J, Prodhan P, Imamura M, Frazier E. Accidental Azygos Vein Extracorporeal Membrane Oxygenation Cannulation in a Neonate with Premature Closure of the Ductus Arteriosus. ASAIO J. 2011 Jul-Aug; 57(4): 344-5.
James F. Cnota, MD
Associate Professor, UC Department of Pediatrics
Fetal cardiology including fetal echocardiography
Impact of insulin sensitivity on left ventricular mass in healthy teens; blood pressure in offspring of preeclamptic mothers; fetal programming of cardiovascular outcomes; multicenter trials in pediatric heart disease
BS: Molecular and Cellular Biology, University of Arizona, Tucson, Arizona, 1991
MD: Tulane University School of Medicine, New Orleans, Louisiana, 1995
Residency: University of Arizona Health Sciences Center, Tucson, Arizona, 1998
Fellowship: Cardiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, 2001
MS: Clinical Epidemiology and Health Services Research, Wake Forest University School of Medicine, Winston-Salem, North Carolina, 2005
Divanović A, Hor K, Cnota J, Hirsch R, Kinsel-Ziter M, Michelfelder E. Prediction and perinatal management of severely restrictive atrial septum in fetuses with critical left heart obstruction: Clinical experience using pulmonary venous Doppler analysis. J Thorac Cardiovasc Surg. 2010 Dec 2. Crombleholme TM, Lim FY, Habli M, Polzin W, Jaekle R, Michelfelder E, Cnota J, Liu C, Kim MO. Improved recipient survival with maternal nifedipine in twin-twin transfusion syndrome complicated by TTTS cardiomyopathy undergoing selective fetoscopic laser photocoagulation. Am J Obstet Gynecol. 2010 Oct;203(4):397.e1-9. Habli M, Cnota J, Michelfelder E, Salisbury S, Schnell B, Polzin W, Lim FY, Crombleholme TM. The relationship between amniotic fluid levels of brain-type natriuretic peptide and recipient cardiomyopathy in twin-twin transfusion syndrome. Am J Obstet Gynecol. 2010 Oct;203(4):404.e1-7. Hambrook JT, Kimball TR, Khoury P, Cnota J. Disparities exist in the emergency department evaluation of pediatric chest pain. Congenit Heart Dis. 2010 May-Jun;5(3):285-91. Vuletin JF, Lim FY, Cnota J, Kline-Fath B, Salisbury S, Haberman B, Kingma P, Frischer J, Crombleholme T. Prenatal pulmonary hypertension index: novel prenatal predictor of severe postnatal pulmonary artery hypertension in antenatally diagnosed congenital diaphragmatic hernia. J Pediatr Surg. 2010 Apr;45(4):703-8. Hor KN, Gottliebson WM, Carson C, Wash E, Cnota J, Fleck R, Wansapura J, Klimeczek P, Al-Khalidi HR, Chung ES, Benson DW, Mazur W. Comparison of magnetic resonance feature tracking for strain calculation with harmonic phase imaging analysis. JACC Cardiovasc Imaging. 2010 Feb;3(2):144-51. Land MH, Rouster-Stevens K, Woods CR, Cannon ML, Cnota J, Shetty AK. Lactobacillus sepsis associated with probiotic therapy. Pediatrics. 2005 Jan;115(1):178-81.
Grace BE, Cnota JF, Hines MH, Payne RM, Ririe DO. Traumatic Coronary Artery Fistula in a Child. Circulation 2005;1 II :e272-e273.
Lisa M. DiPietro, MD Clinical Fellow, Cardiology Clinic, Heart Institute
Clinical Fellow, Cardiology Clinic, Heart Institute
MD: Tufts University School of Medicine, Boston, MA, 2011.
Residency: Pediatrics, Medical University of South Carolina, Charleston, SC.
Allison A. Divanovic, MD Co-Director, Medical Student/Resident Education, Heart Institute
Co-Director, Medical Student/Resident Education, Heart Institute
Pediatric cardiology; fetal and neonatal cardiology; transthoracic, transesophageal and fetal echocardiography
Echocardiographic predictors of cardiac involvement in the fetus with twin-twin transfusion syndrome; risk factors for intrauterine fetal demise in the fetus with congenital heart disease; Improvement in the prenatal identification of fetal coarctation; prediction of atrial septal restriction in the fetus with HLHS
Villa CR, Habli M, Votava-Smith JK, Cnota JF, Lim FY, Divanovic AA, Wang Y, Michelfelder EC. Assessment of Fetal Cardiomyopathy in Early Stage Twin-Twin Transfusion Syndrome: Comparison between Commonly Reported Cardiovascular Assessment Scores. Ultrasound Obstet Gynecol. 2013 Oct 21. Epub ahead of print.
Cnota JF, Hangge PT, Wang Y, Woo JG, Hinton AC, Divanovic AA, Michelfelder EC, Hinton RB. Somatic Growth Trajectory in the Fetus with Hypoplastic Left Heart Syndrome. Pediatr Res. 2013 Sep;74(3):284-9.
Hangge P, Cnota JF, Woo JG, Hinton AC, Divanovic AA, Manning PB, Ittenbach RF, Hinton RB. Microcephaly is Associated with Early Adverse Neurologic Outcomes in Hypoplastic Left Heart Syndrome. Pediatr Res. 2013 Jul;74(1):61-7.
Statile CJ, Cnota JF, Gomien S, Divanović AA, Crombleholme T, Michelfelder E. Estimated Cardiac Output and Cardiovascular Profile Score in Fetuses with High Cardiac Output Lesions. Ultrasound Obstet Gynecol. 2013 Jan:41(1):54-8.
Divanović A, Witte D, Michelfelder E. A Fetus with Hypoplastic Left Heart Syndrome and Tricuspid Stenosis with Evolving Hydrops Fetalis. Pediatr Cardiol. 2012 Oct;33(7):1210-12.
Sheridan RM, Michelfelder EC, Choe KA, Divanovic A, Ware S, Liu C, Stanek JW. Ductus Arteriosus Aneurysm with Massive Thrombosis of Pulmonary Artery. Pediatr Dev Pathol. 2012 Jan-Feb;15(1):79-85.
Divanović A, Cnota J, Ittenbach R, Tan X, Border W, Crombleholme T, Michelfelder E. Characterization of Diastolic Dysfunction in Twin-Twin Transfusion Syndrome: Association between Doppler Findings and Ventricular Hypertrophy. J Am Soc Echocardiogr. 2011 Aug;24(8):834-40.
Divanović A, Hor K, Cnota J, Hirsch R, Kinsel-Ziter M, Michelfelder E. Prediction and Perinatal Management of Severely Restrictive Atrial Septum in Fetuses with Critical Left Heart Obstruction: Clinical Experience Using Pulmonary Venous Doppler Analysis. J Thorac Cardiovasc Surg. 2011 Apr;141(4):988-94.
Gudausky TM, Pearl J, Dent CL, Kim E, Divanović A, Spicer R, Beekman RH 3rd. Open-chest Epicardial Approach to Transcatheter Pulmonary Artery Stenting Following Heart Transplantation in an Infant. Congenital Heart Dis. 2007; Vol 2(1):64-9.
Bryan H. Goldstein, MD
Cardiac catheterization; intervention for congenital heart disease; transcatheter valve implantation; single ventricle physiology
Bryan H. Goldstein, MD, joined the Heart Institute in August 2011 in the section of cardiac catheterization and intervention. He was previously a clinical lecturer at the University of Michigan where he completed fellowship training.
A native of Boston, MA, Dr. Goldstein graduated with Distinction and Honors from Amherst College, where he was a goalie on the men's lacrosse team. He earned his medical degree with Honors from Boston University School of Medicine. He completed his pediatric internship and residency in the Boston Combined Residency in Pediatrics (Children's Hospital Boston) and his pediatric cardiology and interventional cardiology fellowships at the University of Michigan (C.S. Mott Children's Hospital) in Ann Arbor, MI.
Dr. Goldstein’s clinical expertise is in congenital cardiac catheterization. He is interested in invasive physiologic assessment of complex congenital heart disease, including single ventricle physiology, as well as minimally invasive transcatheter therapies. Dr. Goldstein is also interested in furthering hybrid therapies offered for congenital heart disease in patients both young and old.
Dr. Goldstein’s research interests include novel transcatheter interventions (including fetal therapy) and long-term outcomes following interventions for congenital heart disease. An additional research focus includes long-term functional outcomes following Fontan palliation for single ventricle physiology. Dr. Goldstein previously served as a co-investigator for the Melody™ Transcatheter Pulmonary Valve Post-Approval Study.
Dr. Goldstein is an active member of the American Heart Association, American College of Cardiology, Society of Cardiovascular Angiography and Interventions, and American Academy of Pediatrics.
MD: Boston University School of Medicine, Boston, MA, 2004.
Residency: Pediatrics, Children’s Hospital Boston, Boston, MA, 2007.
Fellowship: Pediatric Cardiology, C.S. Mott Children’s Hospital, Ann Arbor, MI, 2010.
Advanced Fellowship: Interventional Cardiology, C.S. Mott Children’s Hospital, Ann Arbor, MI, 2011.
Certifications: Pediatrics, 2007; Pediatric Cardiology, 2010.
Goldstein BH, Golbus JR, Sandelin AM, Warnke N, Gooding L, King KK, Donohue JE, Yu S, Gurney JG, Goldberg CS, Rocchini AP, Charpie JR. Impact of Vitamin C on Endothelial Function and Exercise Capacity in Patients with a Fontan Circulation. Congenit Heart Dis. 2011.
Goldstein BH, Aiyagari R, Bocks ML, Armstrong AK. Hydrogel Expandable Coils for Vascular Occlusion in Congenital Cardiovascular Disease: A Single Center Experience. Congenit Heart Dis. 2011.
Goldstein BH, Fifer CG, Armstrong AK, Gelehrter SK, Treadwell MC, van de Ven C, Rocchini AP. Use of a Pressure Guidewire in Fetal Cardiac Intervention for Critical Aortic Stenosis. Pediatrics. 2011 Aug 15.
Schumacher KR, Cools M, Goldstein BH, Ioffe-Dahan V, King K, Gaffney D, Russell MW. Oral Budesonide Treatment for Protein Losing Enteropathy in Fontan-Palliated Patients. Pediatr Cardiol. 2011 Oct;32(7):966-71.
Goldstein BH, Golbus JR, Sandelin AM, Warnke N, Gooding L, King KK, Donohue JE, Gurney JG, Goldberg CS, Rocchini AP, Charpie JR. Usefulness of Peripheral Vascular Function to Predict Functional Health Status in Patients with a Fontan Circulation. Am J Cardiol. 2011 Aug 1;108(3):428-34.
Goldstein BH, Bergersen L, Powell AJ, Graham D, Bacha E, Lang P. Long-Term Outcome of Surgically Repaired Unilateral Anomalous Pulmonary Artery Origin. Pediatr Cardiol. 2010 Oct;31(7):944-51.
Goldstein BH, Connor C, Gooding L, Rocchini AP. Relation of Systemic Venous Return, Diastolic Dysfunction and Pulmonary Vascular Resistance to Exercise Capacity in Patients with Single Ventricle Receiving Fontan Palliation. Am J Cardiol. 2010 Apr 15;105(8):1169-75.
Brandon S. Hays, MD Clinical Fellow, Heart Institute
Clinical Fellow, Heart Institute
MD: Columbia University College of Physicians and Surgeons, New York, NY.
Residency: University of Minnesota, Minneapolis, MN.
Haleh C. Heydarian, MD Cardiologist, Cardiology Clinic
Cardiologist, Cardiology Clinic
Dyssynchrony; quality improvement
Ilias D. Iliopoulos, MD Attending Cardiac Intensivist, Cardiac Intensive Care Unit
MD: Aristotle University Medical School, Thessaloniki, Greece, 1997.
Residency: Royal College of Paediatrics and Child Health, London, UK, 2005.
Fellowship: Neonatal-Perinatal Medicine, Royal London Hospital and Homerton Hospital, London, UK, 2008.
Pediatric Intensive Care: Evelina Children's Hospital, Guy's and St. Thomas Hospital, London, UK, 2009.
Pediatric Cardiac Intensive Care: Royal Brompton Hospital, London, UK, 2010-2011.
Pediatric Cardiac Critical Care Fellowship: Miami Children's Hospital, Miami, FL, 2012.
Lane T. Lanier, MD Clinical Fellow, Heart Institute
MD: University of Texas Health Science Center at San Antonio, San Antonio, TX, 2005.
Residency: Pediatrics, University of Oklahoma, Oklahoma City, OK.
Fellowship: Pediatric Critical Care, University of Texas Southwestern, Dallas, TX.
Certification: Pediatrics, 2008.
Christopher P. Learn, MD
UC Department of Internal Medicine
Adolescent and adult congenital heart disease; non-invasive cardiovascular imaging
MD: Boston University, Boston, MA, 2003.
Residency: Internal Medicine-Pediatrics, Indiana University Hospital, Indianapolis, IN, 2007.
Fellowship: Cardiovascular Medicine, The Ohio State University Medical Center, Columbus, OH, 2012. Pediatric Cardiology, Nationwide Children’s Hospital, Columbus, OH, 2012.
Certification: Internal Medicine, 2008; General Pediatrics, 2008; Pediatric Cardiology, 2012; (Adult) Cardiovascular Medicine, 2013; National Board of Echocardiography ASCeXAM, 2013; Diplomate - Adult Comprehensive Echocardiography, National Board of Echocardiography.
Learn CP, Holzer RJ, Daniels CJ, Torres AJ, Vincent JA, Moore JW, Armsby LB, Landzberg MJ, Bergensen L. Adverse events rates and risk factors in adults undergoing cardiac catheterization at pediatric hospitals — results from the C3PO. Catheter Cardiovasc Inerv. 2013 May;81(6):997-1005.
Learn C, Phillips A, Chisolm J, Hill S, Cheatham J, Winch P, Galantowicz M, Holzer R. Pulmonary atresia with ventricular septal defect and multifocal pulmonary blood supply: does an intensive interventional approach improve the outcome? Congenit Heart Dis. 2012 Mar-Apr;7(2):111-21.
Learn CP, Yates AR, Nicholson L, Milton K, Lloyd E, Cua CL. Tissue Doppler measurements correlate with central venous pressure in pediatric patients after cardiac surgery. ASAIO J. 2010 Jul-Aug;56(4):377-82.
Lisa A. Lee, MD Pediatric Cardiologist, Heart Institute / Cardiology Clinic
Pediatric Cardiologist, Heart Institute / Cardiology Clinic
Outpatient clinical management of cardiac disease; echocardiography
BA: Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO, 1989.
MD: University of Cincinnati College of Medicine, Cincinnati, Ohio, 1993.Residency: Cincinnati Children's Hospital, Cincinnati, Ohio, 1993-1996.Fellowships: Pediatric Resident, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 1994-1996. Pediatric Cardiology, C.S. Mott Children's Hospital, University of Michigan, Ann Arbor, Michigan 1997-2000; Pediatric Echocardiography, Cincinnati Children's Hospital, Cincinnati, Ohio, 2000-2001.
Certification: Pediatrics, 1996; Pediatric Cardiology, 2000.
Lee LA. Innocent murmurs. Presented to the family practice residents and St. Elizabeth Medical Center, Edgewood, KY. January 10, 2003
Lee LA. Stress echocardiography in children. Pediatric Ultrasound Today. 2001 Volume 6, Lesson 4.
Lee LA, Goya G, Witt SA, Flascock BJ, Mays W, Kimball TR. Resting predictors of latent stress-induced left ventricular outflow tract obstruction in young patients with hypertrophic cardiomyopathy. J Am Coll Cardiology. 2001 Oct.
Lee LA. Evaluation and management of hypertension in children. Presented to nurse practitioner students, University of Michigan School of Nursing, Ann Arbor, MI. March 2000.
Lee LA, Simon C, Bove EL, Mosca RS, Ebbini ES, Abrams GD, Ludomirsky A. High-intensity focused ultrasound effect on cardiac tissues: potential for clinical application. Echocardiography. 2000 Aug; 17(6 Pt 1):563-6.
Ohye RG, Kagisaki K, Lee LA, Mosca RS, Goldberg CS, Bove EL. Biventricular repair for aortic atresia or
hypoplasia and ventricular septal defect. J Thorac Cardiovasc Surg. 1999;118(4):648-53.
Lee LA, Kimball TR, Daniels SR, Khoury P, Meyer RA. Left ventricular mechanics in the preterm infant and their effect on the measurement of cardiac performance. J Pediatr. 1992 Jan;120(1):114-9..
Nicolas L. Madsen, MD, MPH
Inpatient and preventative cardiology
Nicolas L. Madsen, MD, MPH joined the Heart Institute in July 2012. He attended the University of California at Davis, where he graduated with honors. He earned his medical degree with honors at the University of Washington in 2005. Dr. Madsen completed his residency in General Pediatrics and his fellowship in Pediatric Cardiology at Seattle Children’s Hospital in Seattle, Washington. In addition, Dr. Madsen earned a Master’s in Public Health from the University of Washington in 2011.
Dr. Madsen’s clinical focus is in general and preventative cardiology. His research interests also focus on the prevention of cardiac disease processes. Specifically, Dr. Madsen aims to understand the implications of traditional cardiovascular risk factors such as obesity, hypertension and sedentary lifestyle on persons with congenital heart disease. Additionally, he is focused on the prevention of sudden cardiac death in adolescent athletes by way of optimizing preparticipation sports screening. Dr. Madsen has received several national awards for his research and is an active member of the American Heart Association and American Academy of Pediatrics.
MD: University of Washington School of Medicine, Seattle, WA, 2005.
MPH: University of Washington School of Public Health, Seattle, WA, 2011.
Residency: Pediatrics, Seattle Children’s Hospital, Seattle, WA.
Fellowship: Cardiology, Seattle Children’s Hospital, Seattle, WA.
Peace Chike Madueme, MD, MS
Echocardiography, fetal echocardiography, cardiac MRI/CT
Peace Madueme is an assistant professor of pediatrics with the University College of Medicine. He is a faculty member that specializes in cardiac imaging.
Dr. Madueme completed his residency and fellowship training at Cincinnati Children's Hospital Medical Center and has been at the hospital since 2005. Dr. Madueme has been a member of the Division of Cardiology/Heart Institute since 2008. His clinical and research focus relate to cardiac imaging by echocardiography, fetal echocardiography and cardiac MRI.
Dr. Madueme is a member of the American Academy of Pediatrics, American College of Cardiology, American Society of Echocardiography and the Society of Cardiovascular Magnetic Resonance.
Undergraduate: BSc & BPHE Queen's University, Canada, 2001.
MD: Eastern Virginia Medical School, Norfolk, VA, 2005.
Residency: Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2008.
Fellowship: Pediatric Cardiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2011.
Advanced Fellowship: Cardiac Imaging, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2012.
Certification: Pediatrics, 2011 and Pediatric Cardiology, 2012.
Madueme PC, Mazur W, Hor KN, Germann JT, Jefferies JL, Taylor MD. Comparison of the Area-Length Method by Echocardiography versus Full Volume Quantification by Cardiac Magnetic Resonance Imaging for the Assessment of Left Atrial Volumes. Pediatr Cardiol. 2013 Nov 17. Epub ahead of print.
Madueme PC, Khoury PR, Urbina EM, Kimball TR. Predictors for Elevated Exercise-Induced Systolic Blood Pressures in Pediatric Patients after Successful Coarctation Repair. Cardiol Young. 2013 Jun;23(3)416-22.
Madueme PC, Hinton R. Tuberous sclerosis and cardiac rhabdomyomas: A case report and review of the literature. Congenit Heart Dis. 2011 Mar-Apr;6(2):183-7.
Erik C. Michelfelder, MD Co-Director, Cardiac Imaging Services, Heart Institute
Co-Director, Cardiac Imaging Services, Heart Institute
Director, Fetal Heart Program, Heart Institute
Erik C. Michelfelder Sr., MD, is a professor of pediatrics with the University of Cincinnati College of Medicine. He is currently director of the Fetal Heart Program, and co-director of Cardiac Imaging Services for the Heart Institute at Cincinnati Children’s Hospital Medical Center.
Dr. Michelfelder graduated with a degree in biology from Bucknell University and earned his MD from the Penn State University College of Medicine. He completed his residency in pediatrics at St. Christopher’s Hospital for Children in Philadelphia, and his cardiology fellowship at C.S. Mott Children’s Hospital at the University of Michigan in Ann Arbor.
Dr. Michelfelder has been a member of the Division of Cardiology at Cincinnati Children’s Hospital Medical Center since 1998. His clinical and academic focus relate to fetal cardiology and echocardiography.
He is a member of the American Society of Echocardiography, The American Heart Association, The American College of Cardiology, The American Academy of Pediatrics, and the Society for Pediatric Research.
BS: Bucknell University, Lewisburg, PA, 1986.
MD: Penn State University College of Medicine, Hershey, Pennsylvania, 1990.Residency: St. Christopher's Hospital for Children, Temple University School of Medicine, Philadelphia, Pennsylvania, 1990-1993.Fellowship: C.S. Mott Children's Hospital, University of Michigan Medical Center, Ann Arbor, Michigan, 1993-1996.Certification: Pediatrics 1991, Pediatric Cardiology 1998.
Ngamprasertwong P, Michelfelder EC, Arbabi S, Choi YS, Statile C, Ding L, Boat A, Eghtesady P, Holland K, Sadhasivam S. Anesthetic Techniques for Fetal Surgery: Effects of Maternal Anesthesia on Intraoperative Fetal Outcomes in Sheep Model. Anesthesiology. 2013 Apr;118(4):796-808.
Statile C, Cnota J, Gomien S, Divanovic A, Crombleholme T, Michelfelder EC. Estimated Cardiac Output and Cardiovascular Profile Score in Fetuses with High Cardiac Output Lesions. Ultrasound Obstet Gynecol. 2013 Jan;41(1):54-8.
Williams IA, Fifer C, Jaeggi E, Levine J, Michelfelder EC, Garfinkel R, Szwast AL. The Association of Fetal Cerebrovascular Resistance with Early Neurodevelopment in Single Ventricle Congenital Heart Disease. Am Heart J. 2013;165(4):544-50.
Habli M, Michelfelder EC, Cnota J, Wall D, Polzin W, Lewis D, Lim FY, Crombleholme TM. Prevalence and Progression of Recipient-twin Cardiomyopathy in Early-stage Twin-twin Transfusion Syndrome. Ultrasound Obstet Gynecol. 2012 Jan;39(1):63-8.
Divanovic A, Cnota JF, Ittenbach R, Tan X, Border WL, Crombleholme T, Michelfelder E. Characterization of Diastolic Dysfunction in Twin-Twin Transfusion Syndrome: Association between Doppler Findings and Ventricular Hypertrophy. J Am Soc Echocardiogr. 2011 Aug;24(8):834-40.
Divanovic A, Hor K, Cnota JF, Hirsch R, Kinsel-Ziter M, Michelfelder EC. Prediction and Perinatal Management of Severely Restrictive Atrial Septum in Fetuses With Critical Left Heart Obstruction: Clinical Experience Using Pulmonary Venous Doppler Analysis. J Thorac Cardiovasc Surg. 2011 Apr;141(4):988-94.
Kinsel-Ziter ML, Cnota JF, Crombleholme TM, Michelfelder EC. Twin-Reversed Arterial Perfusion Sequence: Pre- and Post- Operative Cardiovascular Findings in the Pump Twin. Ultrasound Obstet Gynecol. 2009 Nov;34(5):550-5.
Shah AD, Border WL, Crombleholme TM, Michelfelder EC. Initial Fetal Cardiovascular Profile Score Predicts Recipient Twin Outcome in Twin-Twin Transfusion Syndrome. J Am Soc Echocardiogr. 2008 Oct; 21(10):1105-8.
Michelfelder EC, Gottliebson WM, Border WL, Kinsel ML, Polzin WJ, Livingston JC, Khoury P, Crombleholme TM. Early Manifestations and Spectrum of Recipient Twin Cardiomyopathy in Twin-Twin Transfusion Syndrome: Relation to Quintero Stage. Ultrasound Obstet Gynecol. 2007 Dec;30(7):965-71.
Michelfelder EC, Gomez CA, Border W, Gottliebson W, Franklin C. Predictive Value of Fetal Pulmonary Venous Flow Patterns in Identifying the Need for Atrial Septoplasty in the Newborn With Hypoplastic Left Ventricle. Circulation. 2005 Nov 8;112(19):2974-79.
Lindsay S. Rogers, MD Attending Cardiologist, Cardiology Clinic, Heart Institute
Attending Cardiologist, Cardiology Clinic, Heart Institute
Non-invasive imaging; fetal cardiology; cardiac morphology
BS: Biology, James Madison University, Harrisonburg, VA, 2000.
MD: State University of New Yort at Buffalo, Buffalo, NY, 2005.
Residency: Hasbro Children's Hospital, Brown University, Providence, RI, 2008.
Fellowship: The Children's Hospital of Philadelphia, Philadelphia, PA, 2012.
Certifications: Pediatrics and Pediatric Cardiology.
Murphy MO, Glatz AC, Goldberg DJ, Rogers LS, Ravishankar C, Nicolson SC, Steven JM, Fuller S, Spray TL, Gaynor JW. Management of early Fontan Failure: a single-institution experience. Eur J Cardiothorac Surg. 2014 Feb 19. Epub ahead of print.
Rogers L, Goldberg DJ. Reply: The Fontan Operation Starts with the Cavopulmonary Shunt. J Am Coll Cardiol. 2013;61(14):1551-1552.
Rogers L, Li J, Liu L, Balluz R, Rychik J, Ge S. Advances in Fetal Echocardiography: Early Imaging, Three/Four Dimensional Imaging, and Role of Fetal Echocardiography in Guiding Early Postnatal Management of Congenital Heart Disease. Echocardiography. 2013 Apr;30(4):428-38.
Rogers LS, Glatz AC, Ravishankar C, Spray TL, Nicolson SC, Rychik J, Rush CH, Gaynor JW, Goldberg DJ. 18 Years of the Fontan Operation at a Single Institution: Results from 771 Consecutive Patients. J Am Coll Cardiol. 2012 Sep 11;60(11):1018-25.
Rogers LS, Peterson AL, Rome JJ, Gaynor JW, Weinberg PM, Rychik J. Mitral Valve Dysplasia Syndrome: A Unique Form of Left-Sided Heart Disease. J Thorac Cardiovasc Surg. 2011 Dec;142(6):1381-7.
James J. Starc, MD Clinical Cardiology Fellow, Heart Institute
Clinical Cardiology Fellow, Heart Institute
MD: Mount Sinai School of Medicine, New York, NY, 2009.
Residency: Pediatrics, Mount Sinai School of Medicine, New York, NY.
Christopher J. Statile, MD Pediatric Cardiologist, Heart Institute
Pediatric Cardiologist, Heart Institute
Pediatric cardiology, fetal cardiology, echocardiography
Fetal cardiology, quality improvement in the echo lab
Christopher Statile, MD, is a pediatric cardiologist who has interest in clinical research in fetal cardiology. He has interest in extra-cardiac congenital lesions and their hemodynamic effects on the fetus. He is also interested in the prenatal diagnosis of congenital heart disease and the outcomes of those fetuses. He is also involved in quality improvement work in the echo lab.
Undergrad: University of Pittsburgh.
MD: Eastern Virginia Medical School.
Residency: Pediatrics, Cincinnati Children's Hospital Medical Center.
Fellowship: Pediatric Cardiology, Cincinnati Children's Hospital.
Sub Fellowship: Fetal Cardiology/Imaging.
Statile CJ, Taylor MD, Mazur W, Cripe LH, King E, Pratt J, Benson DW, Hor KN. Left Ventricular Noncompaction in Duchenne Muscular Dystrophy. J Cardiovasc Magn Reson. 2013 Aug 1;15(1):67.
Ngamprasertwong P, Michelfelder EC, Arbabi S, Choe Y, Statile C, Ding L, Boat A, Eghtesady P, Holland K, Sadhasivam S. Anesthetic Techniques for Fetal Surgery: Effects of Maternal Anesthesia on Intraoperative Fetal Outcomes in Sheep Model. Anesthesiology. 2013 Apr;118(4):796-808.
Statile C, Cnota J, Gomien S, Divanovic A, Crombleholme T, Michelfelder E. Estimated Cardiac Output and Cardiovascular Profile Score in Fetuses with High Output Lesions. Ultrasound Obstet Gynecol. 2013 Jan;41(1):54-58.
Joshua J. Sticka, MD Cardiologist, Heart Institute
Cardiologist, Heart Institute
Cardiac MRI; transthoracic and transesophageal echocardiography; myocardial mechanics
Joshua Sticka, MD, is an assistant professor of pediatrics at University of Cincinnati and a clinical cardiologist within the Heart Institute at Cincinnati Children’s Hospital Medical Center.
Dr. Sticka is a native of Montana and completed his undergraduate degree with honors in astrophysics at the University of Montana. While in medical school at the University of Washington School of Medicine he was selected to participate in the highly competitive WRITE program and studied rural medicine in northern Idaho. During his pediatric training at the University of California San Diego he won several awards and was asked to stay on to work as an attending physician at Rady Children’s Hospital in the department of Emergency Medicine. He subsequently moved to Denver, CO to obtain his pediatric cardiology training from the University of Colorado and completed an additional year of advanced fellowship training in non-invasive cardiac imaging there as well. Dr. Sticka joined the imaging section of the Heart Institute in August 2011 as a clinical cardiologist with specialization in cardiac MRI and echocardiography.
MD: University of Washington School of Medicine, Seattle, WA, 2003.
Residency: Pediatrics, University of California San Diego, San Diego, CA, 2006.
Fellowship: Pediatric Cardiology, University of Colorado, Denver, CO, 2010.
Advanced Fellowship: Non-invasive Cardiac Imaging, University of Colorado, Denver, CO, 2011.
Certification: Pediatrics, 2007.
Arnold W. Strauss, MD Associate Director for External Relations and Strategic Projects, Cincinnati Children's Research Foundation
Associate Director for External Relations and Strategic Projects, Cincinnati Children's Research Foundation
Arnold Strauss, MD, joined Cincinnati Children's in April, 2007, as chairman of the Department of Pediatrics at the UC College of Medicine, chief medical officer of Cincinnati Children's and director of the Cincinnati Children's Research Foundation. He is the seventh B.K. Rachford Memorial Chair in Pediatrics.
Dr. Strauss is a distinguished pediatric cardiologist, scientist, educator and leader. Prior to his arrival at Cincinnati Children's, he was the chairman of the Department of Pediatrics at the Vanderbilt University School of Medicine and medical director of the Monroe Carell Jr. Children's Hospital at Vanderbilt, a position he held from 2000 to 2007. Under his leadership, the university built and opened a new hospital for children, expanded its pediatric faculty and increased grant funding for pediatric research. From 1981 to 2000, Strauss was director of the Division of Pediatric Cardiology at Washington University/St. Louis Children's Hospital.
A respected scientist, Dr. Strauss' research focuses on understanding the molecular basis of disorders of mitochondrial fatty acid oxidation and the genetic causes of congenital heart disease and cardiomyopathies. He is the recipient of two of the most prestigious awards in research. In November 2006 he was awarded the American Heart Association's Basic Science Research Award for groundbreaking work that led to finding genetic defects that can cause heart failure and sudden death in infants and children. In 1991 he received the E. Mead Johnson Award for Excellence in Pediatric Research.
Liebig M, Schymik I, Mueller M, Wendel U, Mayatepek E, Ruiter J, Strauss AW, Wanders RJ, Spiekerkoetter U. (2006) Neonatal screening for very long-chain acyl-coA dehydrogenase deficiency: enzymatic and molecular evaluation of neonates with elevated C14:1-carnitine levels. Pediatrics 118:1065-9.
Khuchua Z, Yue Z, Batts L, Strauss AW. (2006) A zebrafish model of human Barth syndrome reveals the essential role of tafazzin in cardiac development and function. Circ Res 99:201-8.
Exil VJ, Gardner CD, Rottman JN, Sims H, Bartelds B, Khuchua Z, Sindhal R, Ni G, Strauss AW. (2006) Abnormal mitochondrial bioenergetics and heart rate dysfunction in mice lacking very-long-chain acyl-CoA dehydrogenase. Am J Physiol Heart Circ Physiol 290:H1289-97.
Bennett MJ, Russell LK, Tokunaga C, Narayan SB, Tan L, Seegmiller A, Boriack RL, Strauss AW. (2006) Reye-like syndrome resulting from novel missense mutations in mitochondrial medium- and short-chain l-3-hydroxy-acyl-CoA dehydrogenase. Mol Genet Metab 89:74-9.
Strauss AW. (2005) Surprising? Perhaps not. Long-chain fatty acid oxidation during human fetal development. Pediatr Res 57:753-4.
Spiekerkoetter U, Tokunaga C, Wendel U, Mayatepek E, Ijlst L, Vaz FM, van Vlies N, Overmars H, Duran M, Wijburg FA, Wanders RJ, Strauss AW. (2005) Tissue carnitine homeostasis in very-long-chain acyl-CoA dehydrogenase-deficient mice. Pediatr Res 57:760-4.
Shekhawat PS, Matern D, Strauss AW. (2005) Fetal fatty acid oxidation disorders, their effect on maternal health and neonatal outcome: impact of expanded newborn screening on their diagnosis and management. Pediatr Res 57:78R-86R.
Djouadi F, Aubey F, Schlemmer D, Ruiter JP, Wanders RJ, Strauss AW, Bastin J. (2005) Bezafibrate increases very-long-chain acyl-CoA dehydrogenase protein and mRNA expression in deficient fibroblasts and is a potential therapy for fatty acid oxidation disorders. Hum Mol Genet 14:2695-703.
Browning MF, Larson C, Strauss A, Marsden DL. (2005) Normal acylcarnitine levels during confirmation of abnormal newborn screening in long-chain fatty acid oxidation defects. J Inherit Metab Dis 28:545-50.
Strauss AW. (2004) Tandem mass spectrometry in discovery of disorders of the metabolome. J Clin Invest 113:354-6.
Spierkerkoetter U, Khuchua Z, Yue Z, Strauss AW. (2004) The early-onset phenotype of mitochondrial trifunctional protein deficiency: a lethal disorder with multiple tissue involvement. J Inherit Metab Dis 27:294-6.
Spiekerkoetter U, Tokunaga C, Wendel U, Mayatepek E, Exil V, Duran M, Wijburg FA, Wanders RJ, Strauss AW. (2004) Changes in blood carnitine and acylcarnitine profiles of very long-chain acyl-CoA dehydrogenase-deficient mice subjected to stress. Eur J Clin Invest 34:191-6.
Spiekerkoetter U, Khuchua Z, Yue Z, Bennett MJ, Strauss AW. (2004) General mitochondrial trifunctional protein (TFP) deficiency as a result of either alpha- or beta-subunit mutations exhibits similar phenotypes because mutations in either subunit alter TFP complex expression and subunit turnover. Pediatr Res 55:190-6.
Spiekerkoetter U, Bennett MJ, Ben-Zeev B, Strauss AW, Tein I. (2004) Peripheral neuropathy, episodic myoglobinuria, and respiratory failure in deficiency of the mitochondrial trifunctional protein. Muscle Nerve 29:66-72.
McKinney JT, Longo N, Hahn SH, Matern D, Rinaldo P, Strauss AW, Dobrowolski SF. (2004) Rapid, comprehensive screening of the human medium chain acyl-CoA dehydrogenase gene. Mol Genet Metab 82:112-20.
Strauss A, Lock JE. (2003) Pediatric cardiomyopathy--a long way to go. N Engl J Med 348:1703-5.
Spiekerkoetter U, Sun B, Zytkovicz T, Wanders R, Strauss AW, Wendel U. (2003) MS/MS-based newborn and family screening detects asymptomatic patients with very-long-chain acyl-CoA dehydrogenase deficiency. J Pediatr 143:335-42.
Spiekerkoetter U, Sun B, Khuchua Z, Bennett MJ, Strauss AW. (2003) Molecular and phenotypic heterogeneity in mitochondrial trifunctional protein deficiency due to beta-subunit mutations. Hum Mutat 21:598-607.
Shekhawat P, Bennett MJ, Sadovsky Y, Nelson DM, Rakheja D, Strauss AW. (2003) Human placenta metabolizes fatty acids: implications for fetal fatty acid oxidation disorders and maternal liver diseases. Am J Physiol Endocrinol Metab 284:E1098-105.
Khuchua Z, Wozniak DF, Bardgett ME, Yue Z, McDonald M, Boero J, Hartman RE, Sims H, Strauss AW. (2003) Deletion of the N-terminus of murine map2 by gene targeting disrupts hippocampal ca1 neuron architecture and alters contextual memory. Neuroscience 119:101-11.
Exil VJ, Roberts RL, Sims H, McLaughlin JE, Malkin RA, Gardner CD, Ni G, Rottman JN, Strauss AW. (2003) Very-long-chain acyl-coenzyme a dehydrogenase deficiency in mice. Circ Res 93:448-55.
Zytkovicz TH, Fitzgerald EF, Marsden D, Larson CA, Shih VE, Johnson DM, Strauss AW, Comeau AM, Eaton RB, Grady GF. (2001) Tandem mass spectrometric analysis for amino, organic, and fatty acid disorders in newborn dried blood spots: a two-year summary from the New England Newborn Screening Program. Clin Chem 47:1945-55.
Ibdah JA, Paul H, Zhao Y, Binford S, Salleng K, Cline M, Matern D, Bennett MJ, Rinaldo P, Strauss AW. (2001) Lack of mitochondrial trifunctional protein in mice causes neonatal hypoglycemia and sudden death. J Clin Invest 107:1403-9.
Barycki JJ, O'Brien LK, Strauss AW, Banaszak LJ. (2000) Sequestration of the active site by interdomain shifting. Crystallographic and spectroscopic evidence for distinct conformations of L-3-hydroxyacyl-CoA dehydrogenase. J Biol Chem 275:27186-96.
Ibdah JA, Bennett MJ, Rinaldo P, Zhao Y, Gibson B, Sims HF, Strauss AW. (1999) A fetal fatty-acid oxidation disorder as a cause of liver disease in pregnant women. N Engl J Med 340:1723-31.
Jeffrey A. Towbin, MD, FAAP, FACC, FAHA Executive Co-Director, Heart Institute; Chief, Pediatric Cardiology
Executive Co-Director, Heart Institute; Chief, Pediatric Cardiology
Director, Heart Institute Diagnostic Laboratory
BS: Biology, University of Cincinnati, 1974.MS: Cell Biology, University of Cincinnati, 1977.MD: University of Cincinnati, 1982.
Residency: Pediatrics, Cincinnati Children's Hospital Medical Center, 1985.
Fellowship: Pediatric Cardiology, Baylor College of Medicine, Texas Children's Hospital, 1989.
McBride KL, Zender GA, Fitzgerald-Butt SM, Seagraves NJ, Fernbach SD, Zapata G, Lewin M, Towbin JA, Belmont JW. Association of common variants in ERBB4 with congenital left ventricular outflow tract obstruction defects. Birth Defects Res A Clin Mol Teratol. 2011 Mar;91(3):162-8.
Fakhro KA, Choi M, Ware SM, Belmont JW, Towbin JA, Lifton RP, Khokha MK, Brueckner M. Rare copy number variations in congenital heart disease patients identify unique genes in left-right patterning. Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):2915-20.
Goldenberg I, Horr S, Moss AJ, Lopes CM, Barsheshet A, McNitt S, Zareba W, Andrews ML, Robinson JL, Locati EH, Ackerman MJ, Benhorin J, Kaufman ES, Napolitano C, Platonov PG, Priori SG, Qi M, Schwartz PJ, Shimizu W, Towbin JA, Vincent GM, Wilde AA, Zhang L. Risk for life-threatening cardiac events in patients with genotype-confirmed long-QT syndrome and normal-range corrected QT intervals. J Am Coll Cardiol. 2010 Dec 28;57(1):51-9.
Towbin JA, Ware SM, Jefferies JL. Heart transplants in pediatric patients: viral infection as a loss predictor. Future Cardiol. 2010 Nov;6(6):735-41.
Foerster SR, Canter CE, Cinar A, Sleeper LA, Webber SA, Pahl E, Kantor PF, Alvarez JA, Colan SD, Jefferies JL, Lamour JM, Margossian R, Messere JE, Rusconi PG, Shaddy RE, Towbin JA, Wilkinson JD, Lipshultz SE. Ventricular remodeling and survival are more favorable for myocarditis than for idiopathic dilated cardiomyopathy in childhood: an outcomes study from the Pediatric Cardiomyopathy Registry. Circ Heart Fail. 2010 Nov 1;3(6):689-97.
Purevjav E, Varela J, Morgado M, Kearney DL, Li H, Taylor MD, Arimura T, Moncman CL, McKenna W, Murphy RT, Labeit S, Vatta M, Bowles NE, Kimura A, Boriek AM, Towbin JA. Nebulette mutations are associated with dilated cardiomyopathy and endocardial fibroelastosis. J Am Coll Cardiol. 2010 Oct 26;56(18):1493-502. Towbin JA. Left ventricular noncompaction: a new form of heart failure. Heart Fail Clin. 2010 Oct;6(4):453-69 Towbin JA. Preface: Heart failure in children. Heart Fail Clin. 2010 Oct;6(4):xvii-iii.
Wilkinson JD, Landy DC, Colan SD, Towbin JA, Sleeper LA, Orav EJ, Cox GF, Canter CE, Hsu DT, Webber SA, Lipshultz SE. The pediatric cardiomyopathy registry and heart failure: key results from the first 15 years. Heart Fail Clin. 2010 Oct;6(4):401-13 Towbin JA. Hypertrophic cardiomyopathy. Pacing Clin Electrophysiol. 2009 Jul;32 Suppl 2:S23-31.
Gruschen R. Veldtman, FRCP, MBChB Director of Inpatient ACHD Services, Heart Institute
Director of Inpatient ACHD Services, Heart Institute
Spectrum of adult congenital heart disease: the Fontan circulation; interventional cardiology; pregnancy cardiology; pulmonary hypertension in congenital heart disease
Gruschen R. Veldtman, FRCP, MBChB, is appointed in the Heart Institute at Cincinnati Children's Hospital Medical Center. His major achievement has been the establishment of patient and science centered clinical programs that serve adult patients with various complexity of congenital heart conditions. His major academic contributions have been in the field of liver disease as it relates to the Fontan circulation.
General Paediatrics and Neonates, Royal Hospital for Sick Children, Glasgow, 1995.
Paediatric Cardiology, Leeds General Infirmary, 1999.
Fellowship: Adult Congenital Heart Disease, Toronto 2000.
Research Fellowship: Hospital For Sick Children Toronto, 2001.
Fellowship: Adult Congenital Heart Disease, Mayo Clinic, 2002.
Fellowship: Paediatric Interventional Cardiology, 2003.
Gary D. Webb, MD Director, Cincinnati Adolescent and Adult Congenital Heart Disease Program
Director, Cincinnati Adolescent and Adult Congenital Heart Disease Program
Gary D. Webb, MD, is a professor of pediatrics and internal medicine at the University of Cincinnati College of Medicine. He is director of the Adolescent and Adult Congenital Heart Program at Cincinnati Children's Hospital Heart Institute.
After receiving a BSC and MDCM from McGill University in Montréal, Québec, he went on to intern at the Royal Victoria Hospital in Montréal, and then to training in internal medicine and cardiology at the University of Toronto. After 8 years as chief of cardiology at the Wellesley Hospital in Toronto, he moved back to Toronto General Hospital.
Beginning in 1980, he was co-director and then director of the Toronto Congenital Cardiac Center for Adults. For several years, he directed the adult cardiology training program at the University of Toronto. He is a fellow of the Royal College of Physicians and Surgeons of Canada in both internal medicine and cardiology. He is a fellow of the American College of Cardiology, and a life member of the European Society of Cardiology.
In 2004, he relocated to Philadelphia, serving as director of the Philadelphia Adult Congenital Heart Center at the University of Pennsylvania. In 2009, he took up his current position at Cincinnati Children's Hospital.
Knowles R, Veldtman G, Hickey EJ, Bradley T, Gengsakul A, Webb GD, Williams WG, McCrindle BW. Functional Health Status of Adults with Tetralogy of Fallot: Marched Comparison with Healthy Siblings. Ann Thorac Surg. 2012 Jul;94(1):124-32.
Webb G. The long road to better ACHD care. Congenital Heart Dis. 2010 May-Jun;5(3):198-205.
Khairy P, Aboulhosn J, Gurvitz MZ, Opotowsky AR, Mongeon FP, Kay J, Valente AM, Earing MG, Lui G, Gersony DR, Cook S, Ting JG, Nickolaus MJ, Webb G, Landzberg MJ, Broberg CS; Alliance for Adult Research in Congenital Cardiology (AARCC). Arrhythmia burden in adults with surgically repaired tetralogy of Fallot: a multi-institutional study. Circulation. 2010 Aug 31;122(9):868-75.
Valente AM, Bhatt AB, Cook S, Earing MG, Gersony DR, Aboulhosn J, Opotowsky AR, Lui G, Gurvitz M, Graham D, Fernandes SM, Khairy P, Webb G, Gerhard-Herman M, Landzberg MJ; AARCC (Alliance for Adult Research in Congenital Cardiology) Investigators. The CALF (Congenital Heart Disease in Adults Lower Extremity Systemic Venous Health in Fontan Patients) study. J Am Coll Cardiol. 2010 Jul 6;56(2):144-50.
Silversides CK, Kiess M, Beauchesne L, Bradley T, Connelly M, Niwa K, Mulder B, Webb G, Colman J, Therrien J. Canadian Cardiovascular Society 2009 Consensus Conference on the management of adults with congenital heart disease: outflow tract obstruction, coarctation of the aorta, tetralogy of Fallot, Ebstein anomaly and Marfan's syndrome. Can J Cardiol. 2010 Mar;26(3):e80-97.
Apitz C, Webb GD, Redington AN. Tetralogy of Fallot. Lancet. 2009 Oct;374(9699):1462-71.
Opotowsky AR, Siddiqi OK, Webb, GD. Trends in hospitalizations for adults with congenital heart disease in the US. J Am Coll Cardiol. 2009 Jul;54(5):460-7.
Schwerzmann M, Salehian O, Harris L, Siu SC, Williams WG, Webb GD, Colman JM, Redington A, Silversides CK. Ventricular arrhythmias and sudden death in adults after a Mustard operations for transposition of the great arteries. Eur Heart J. 2009 Aug;30(15):1873-9.
Hickey EJ, Veldtman G, Bradley TJ, Gengsakul A, Manlhiot C, Williams WG, Webb GD, McCrindle BW. Late risk of outcomes for adults with repaired tetralogy of Fallot from an inception cohort spanning four decades. European Journal of Cardio-thoracic Surgery. 2009 Jan;35(1):156-64.
Tzemos N, Silversides CK, Colman JM, Therrien J, Webb, GD, Mason J, Cocoara E, Sermer M, Siu SC. Late cardiac outcomes after pregnancy in women with congenital aortic stenosis. American Heart Journal. 2009;157(3):474-480.
Wendy Whiteside, MD
Cardiac catheterization; transcatheter interventions in congenital heart disease; rotational angiography
Recurrent coarctation following surgical aortic arch reconstructions; balloon angioplasty for recurrent coarctation; cholesterol levels in Fontan patients; radiation reduction in the cardiac catheterization lab
BA: Washington University in St. Louis, St. Louis, MO, 2002.
MD: Albert Einstein College of Medicine, Bronx, NY, 2006.
Residency: Pediatrics, Children's Hospital & Research Center Oakland, Oakland, CA, 2009.
Fellowship: Pediatric Cardiology, University of Michigan C.S. Mott Children's Hospital, Ann Arbor, MI.
Advanced Fellowship: Pediatric Interventional Cardiology, University of Michigan C.S. Mott Children's Hospital, Ann Arbor, MI.
Certifications: Pediatrics, 2009.
Covi SH, Whiteside W, Yu S, Zampi JD. Pulse Floroscopy Radiation Reduction in a Pediatric Cardiac Catheterization Laboratory. Congenit Heart Dis. 2014 Jun 26. Epub ahead of print.
Whiteside W, Hirsch-Romano J, Yu S, Pasquali SK, Armstrong A. Outcomes associated with balloon angioplasty for recurrent coarctation in neonatal univentricular and biventricular Norwood-type aortic arch reconstructions. Catheter Cardiovasc Interv. 2014 Jun 1;83(7):1124-30.
Whiteside W, Tan M, Yu S, Rocchini A. Low total, low density lipoprotein, high density lipoprotein, and non-high-density-density lipoprotein cholesterol levels in patients with complex congenital heart disease after Fontan palliation. J Pediatr. 2013 Jun;162(6):1199-204.
Gupta P, Whiteside W, Sabati A, Tesoro T, Gossett JM, Tobias JD, Roth SJ. Safety and efficacy of prolonged dexmedetomidine use in critically ill children with heart disease. Pediatr Crit Care Med. 2012 Nov; 13(6):660-6.
Whiteside W, Saba Z, Kurio G. Postnatal growth of rhabdomyoma prior to tumor regression. Pediatr Cardiol. 2010 May; 31(4):541-4.
Li SF, Samson K, Bell M, Whiteside W, Okihara M, Prince J, Kheyfets V, Wall S. Exercise tolerance as a predictor of acute myocardial infarction in emergency department patients with potential acute coronary syndromes. J Emerg Med. 2009 Jan; 36(1):8-11.
Samuel G. Wittekind, MD Pediatric Cardiology Fellow, Division of Cardiology, Heart Institute
Pediatric Cardiology Fellow, Division of Cardiology, Heart Institute
Pediatric cardiology; preventative cardiology; pediatric obesity
MD: University of Washington, Seattle, WA, 2010.
Residency: Pediatrics, University of Washington, Seattle, WA, 2013.
Board Certification: Pediatrics, 2013.
Samuel G. Wittekind, Ofer Yanay, Erin M. Johnson, Edward F. Gibbons. Two pediatric cases of variant neurogenic stress cardiomyopathy after intracranial hemorrhage. Pediatrics. Accepted.
Wittekind S, Salerno J, Rubio A. Pacemaker-associated cyanosis in an adolescent: The answer hiding behind shadows. Images in Paediatric Cardiology. 2012 Dec;14(4):6-10.
Wittekind SG, Lie O, Hubbard S, Viswanathan MN. Ictal asystole: An indication for pacemaker implantation and emerging cause of sudden death. Pacing & Clinical Electrophysiology (PACE). 2012 Jul;35(7):e193-6.
Hu J, Wittekind SG, Barr MM. STAM and Hrs down-regulate ciliary TRP receptors. Molecular Biology of the Cell. 2007 Sep;18(9):3277-89.
Laura Jansen, PA-C Physician Assistant, Division of Pediatric Cardiothoracic Surgery, Heart Institute
Physician Assistant, Division of Pediatric Cardiothoracic Surgery, Heart Institute
Pediatric cardiothoracic surgery; surgery; transplant surgery; cardiology
BS: University of Georgia, Athens, GA, 2009.
Master's of Medical Science, PA-C: Mercer University, Atlanta, GA, 2012.
Physician Assistant Surgical Residency: Norwalk/Yale University School of Medicine, Norwalk, CT, 2013.
David L. S. Morales, MD Chief of Cardiovascular Surgery, Heart Institute, Cardiothoracic Surgery
Chief of Cardiovascular Surgery, Heart Institute, Cardiothoracic Surgery
Clark-Helmsworth Chair of Cardiovascular Surgery
UC Division of Surgery
Congenital heart surgery; heterotaxy syndrome; pediatric heart and lung transplantation; mechanical circulatory support
Clinical and translational research related to mechanical circulatory support and tissue engineering
MD: Yale University School of Medicine, New Haven, CT.
Residency: General and cardiothoracic surgery, New York-Presbyterian Medical Center, Columbia University, New York, NY.Fellowships: Congenital heart surgery, Texas Children’s Hospital, Baylor University, Waco, TX.
Board certifications: Surgery, thoracic surgery, congenital heart surgery.
Ivan Wilmot, MD Heart Failure, Transplant, VAD Physician
Heart Failure, Transplant, VAD Physician
Heart failure, transplantation, and mechanical circulatory support.
Care of children with advanced heart failure requiring mechanical circulatory support bridge to transplant; quality of life in children with heart failure, transplant and mechanical circulatory support (MCS); advanced strain imaging in evaluation of ventricular function in pediatric heart transplant patients.
Ivan Wilmot, MD, graduated summa cum laude from Louisiana State University with a Bachelor's of Science in zoology.
In 1998 he began medical school at Emory University. His general pediatrics residency training took place at the Emory Affiliated Hospitals from 2002 to 2006. He completed his pediatric cardiology fellowship training from 2006 to 2009, and advanced fellowship in heart failure and transplant from 2009 to 2010.
His clinical and research interests focus on heart failure, cardiac transplantation and mechanical circulatory support (MCS).
BS: Louisiana State University, 1998.
MD: Emory University School of Medicine, Atlanta, GA, 2002.
Residency: Emory Affiliated Hospitals, Atlanta, GA, 2005; Chief Resident: Emory Affiliated Hospitals, Atlanta, GA, 2006.
Fellowship: Baylor College of Medicine, Texas Children’s Hospital, Houston, TX, 2009.
Advanced Fellowship: Heart Failure and Transplant, Baylor College of Medicine, Texas Children’s Hospital, Houston, TX, 2010.
Certification: American Board of Pediatrics; American Board of Pediatrics Sub-board of Pediatric Cardiology.
Stapleton GE, Wilmot I, Suh EJ. Cardiac catheterisation of patients with common arterial trunk and transposition of the great arteries. Cardiol Young. 2012 Dec:22(6), 687–690.
Dadlani GH, Braley K, Perez-Colon E, Stapleton G, Crawford M, Turpin D, Wilmot I, Freire G, Decker J, Martinez R. Long-term management of patients with hypoplastic left heart syndrome: the diagnostic approach at All Children's Hospital. Cardiol Young. 2011 Dec:21 Suppl 2, 80–87.
Asante-Korang A, Jacobs JP, Ringewald J, Carapellucci J, Rosenberg K, McKenna D, McCormack J, Wilmot I, Gjeldum A, Lopez-Cepero M, Sleasman J. Management of children undergoing cardiac transplantation with high Panel Reactive Antibodies. Cardiol Young. 2011 Dec:21 Suppl 2, 124–132.
Wilmot I, Morales DL, Price JF, Rossano JW, Kim JJ, Decker JA, McGarry MC, Denfield SW, Dreyer, WJ, Towbin JA, Jeffries JL. Effectiveness of mechanical circulatory support in children with acute fulminant and persistent myocarditis. J Card Fail. 2011 June:17(6), 487–494.
Perez-Colon E, Dadlani GH, Wilmot I, Miller M. Mesalamine-induced myocarditis and coronary vasculitis in a pediatric ulcerative colitis patient: a case report. Case Rep Peditr. 2011; 524364.
Sharef S, Coleman R, Rivenes S, Wilmot I, Altman C, Madden-Fuentes R, Salazar J. Stentless xenograft implantation in aortic position in a 7-year-old girl. Tex Heart Inst J. 2010; 37(3), 347–349.
Wilmot I, Kanter KR, Vincent RN, Berg AM, Mahle WT. OKT3 treatment in refractory pediatric heart transplant rejection. J Heart Lung Transplant. 2005 Nov;24(11):1793-7.
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