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The Cardiomyopathy department is home to specialists with a wide variety of backgrounds and areas of focus. As a team, this diversity makes us better prepared to care for your child’s unique needs. Learn more about our faculty and staff.
Chesney Castleberry, MD Heart Failure, Transplant, VAD Physician
Heart Failure, Transplant, VAD Physician
Assistant Professor, UC Department of Pediatrics
Management and transplantation in patients with palliated congenital heart disease; management of sensitized patients pre- and post- transplant
Transplant immunology; clinical outcomes in heart failure/transplant
MD: University of Texas San Antonio Medical School, San Antonio, TX.
Residency: Pediatrics, Children’s Memorial Hospital, Chicago, IL.
Fellowship: Pediatric cardiology, Children’s Hospital of Wisconsin, Milwaukee, WI; advanced heart failure and transplant, Lucile Packard Children’s Hospital, Palo Alto, CA.
Clifford Chin, MD Medical Director, Pediatric Heart Transplant Services
Medical Director, Pediatric Heart Transplant Services
Professor, UC Department of Pediatrics
Richard J. Czosek, MD
BS: University of Georgia, 1997.
MD: Medical College of of Georgia, 2001.
Residency: Pediatrics, Cincinnati Children's Hospital Medical Center. Cincinnati, OH.
Cardiology Fellowship: Pediatric Cardiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
Fellowship Subspecialty Training: Pediatric Pacing and Electrophysiology, Boston Children's Hospital, Boston, MA.
Walsh MA, Grenier MA, Jefferies JL, Towbin JA, Lorts A, Czosek RJ. Conduction Abnormalities in Pediatric Patients with Restrictive Cardiomyopathy. Circ Heart Fail. 2012 Jan 19. [Epub ahead of print]
Walsh MA, Anderson JB, Knilans TK, Cottrill CM, Czosek RJ. Ventricular Oversensing in a Biventricular Pacemaker. Pacing Clin Electrophysiol. 2012 Jan 13 [Epub ahead of print]
Czosek RJ, Meganathan K, Anderson JB, Knilans TK, Marino BS, Heaton PC. Cardiac rhythm devices in the pediatric population: Utilization and complications. Heart Rhythm. 2012 Feb;9(2):199-208.
Czosek RJ, Anderson JB, Marino BS, Mellion K, Knilans TK. Noninvasive risk stratification techniques in pediatric patients with ventricular preexcitation. Pacing Clin Electrophysiol. 2011;34:555-562.
Czosek RJ, Haaning A, Ware SM. A mouse model of conduction system patterning abnormalities in heterotaxy syndrome. Pediatr Res. 2010;68:275-280.
Czosek RJ, Atallah J, Emani S, Hasan B, del Nido P, Berul CI. Electrical dyssynchrony and endocardial fibroelastosis resection in the rehabilitation of hypoplastic left cardiac syndrome. Cardiol Young. 2010;20:516-52.
Czosek RJ, Anderson JB, Cao J, Knilans TK. Assessment of t-wave oversensing in an infant with an implanted defibrillator. Heart Rhythm. 2010;7:1516-1517
Czosek RJ, Anderson J, Marino BS, Connor C, Knilans TK. Linear lesion cryoablation for the treatment of atrioventricular nodal re-entry tachycardia in pediatrics and young adults. Pacing Clin Electrophysiol. 2010;33:1304-131.
Czosek RJ, Anderson J, Connor C, Knilans T. Nodoventricular pathway associated with twin AV nodes: Complexity of ablation in single ventricle physiology. J Cardiovasc Electrophysiol. 2010;21:936-939.
Czosek RJ, Berul CI. Congenital long-QT syndrome concealed by hypercalcemia in Williams syndrome. J Cardiovasc Electrophysiol. 2008;19:1322-1324.
Lisa M. Dodd, MSSW, LISW Social Worker, The Heart Institute
John Lynn Jefferies, MD, MPH, FAAP, FACC Director, Advanced Heart Failure and Cardiomyopathy
Director, Advanced Heart Failure and Cardiomyopathy
Associate Professor, UC Department of Pediatrics
Dr. Jefferies, an associate professor of pediatric cardiology and adult cardiovascular diseases, is the director of Advanced Heart Failure / Cardiomyopathy within the Heart Institute at Cincinnati Children's Hospital Medical Center.
He completed his combined pediatric and adult cardiology training at the Baylor College of Medicine in Houston, Texas at the Texas Children's Hospital and the Texas Heart Institute. He has authored or co-authored over 100 peer-reviewed manuscripts and book chapters on cardiomyopathy, cardiovascular genetics, and adults with congenital heart disease.
His current research interests include heritable causes of vascular disease, novel drug therapies for advanced heart failure, novel gene discovery in cardiomyopathy, characterization and management of left ventricular noncompaction (LVNC), and early diagnosis and management of chemotherapy induced cardiotoxicity.
He is on the editorial board of the Texas Heart Institute Journal and is an active member of numerous professional organization including the Heart Failure Society of America, the American College of Cardiology and the American Heart Association.
Jefferies JL, Towbin JA. Dilated cardiomyopathy. Lancet. 2010 Feb;375(9716):752-62. Breinholt JP, Moulik M, Dreyer WJ, Denfield SW, Kim JJ, Jefferies JL, Rossano JW, Gates CM, Clunie SK, Bowles KR, Kearney DL, Bowles NE, Towbin JA. Viral epidemiologic shift in inflammatory heart disease: the increasing involvement of parvovirus B19 in the myocardium of pediatric cardiac transplant patients. J Heart Lung Transplant. 2010 Jul;29(7):739-46. Rossano JW, Morales DL, Zafar F, Denfield SW, Kim JJ, Jefferies JL, Dreyer WJ. Impact of antibodies against human leukocyte antigens on long-term outcome in pediatric heart transplant patients: An analysis of the United Network for Organ Sharing database. J Thorac Cardiovasc Surg. 2010 May 26.
Carlson P, Jefferies JL, Kearney D, Russell H. Refractory dilated cardiomyopathy associated with metastatic neuroblastoma. Pediatr Blood Cancer. 2010 Jun 29.
Shah AM, Jefferies JL, Rossano JW, Decker JA, Cannon BC, Kim JJ. Electrocardiographic abnormalities and arrhythmias are strongly associated with the development of cardiomyopathy in muscular dystrophy. Heart Rhythm. 2010 Jun 18. Moulik M, Breinholt JP, Dreyer WJ, Kearney DL, Price JF, Clunie SK, Moffett BS, Kim JJ, Rossano JW, Jefferies JL, Bowles KR, O'Brian Smith E, Bowles NE, Denfield SW, Towbin JA. Viral Endomyocardial Infection Is an Independent Predictor and Potentially Treatable Risk Factor for Graft Loss and Coronary Vasculopathy in Pediatric Cardiac Transplant Recipients. J Am Coll Cardiol. 2010 56:582-592.Shchelochkov OA, Li FY, Wang J, Zhan H, Towbin JA, Jefferies JL, Wong LJ, Scaglia F. Milder Clinical Course of Type IV 3-Methylglutaconic Aciduria Due to a Novel Mutation in TMEM70. Mol Genet Metab. 2010 101:282-285. Foerster SR, Canter CE, Cinar A, Sleeper LA, Webber SA, Pahl E, Kantor PF, Alvarez JA, Colan SD, Jefferies JL, Lamour JM, Margossian R, Messere JE, Rusconi PG, Shaddy RE, Towbin JA, Wilkinson JD, Lipshultz SE. Ventricular Remodeling and Survival are More Favorable for Myocarditis than for Idiopathic Dilated Cardiomyopathy in Childhood: An Outcomes Study from the Pediatric Cardiomyopathy Registry. Circ Heart Fail. 2010. Jefferies JL, Price JF, Morales DL. Mechanical support in childhood heart failure. Heart Fail Clin. 2010 Oct;6(4):559-73. Jefferies JL, Hoffman TM, Nelson DP. Heart failure treatment in the intensive care unit in children. Heart Fail Clin. 2010 Oct;6(4):531-58.
Angela Lorts, MD Director, Ventricular Assist Device Program
Director, Ventricular Assist Device Program
Heart failure; cardiopulmonary bypass mediated myocardial dysfunction
Lorts A, Burroughs T, Shanley TP. Elucidating the role of reversible protein phosphorylation in sepsis-induced myocardial dysfunction. Shock. 2009 Jul;32(1):49-54. Review.
Lorts A, Schwanekamp JA, Elrod JW, Sargent MA, Molkentin JD. Genetic manipulation of periostin expression in the heart does not affect myocyte content, cell cycle activity, or cardiac repair. Circ Res. 2009 Jan 2;104(1):e1-7.
Oka T, Xu J, Kaiser RA, Melendez J, Hambleton M, Sargent MA, Lorts A, Brunskill EW, Dorn GW 2nd, Conway SJ, Aronow BJ, Robbins J, Molkentin JD. Genetic manipulation of periostin expression reveals a role in cardiac hypertrophy and ventricular remodeling. Circ Res. 2007 Aug 3;101(3):313-21.
McLean KM, Lorts A, Pearl JM. Current treatments for congenital aortic stenosis. Curr Opin Cardiol. 2006 May;21(3):200-4. Review.
Thomas D. Ryan, MD, PhD Heart Failure, Transplant, VAD Physician
Cardiomyopathy; heart failure; heart transplantation; mechanical circulatory support
Development of cardiomyopathy in at risk populations, including Duchenne muscular dystrophy and other genetic cardiomyopathies, and anthracycline exposure.
Thomas D Ryan, MD, PhD, was born and raised in Wichita, KS and graduated magna cum laude from Wichita State University in 1996 with a BS in Biological Sciences.
In 1997 he began training in the MD/PhD program at the University of Alabama at Birmingham, and studied the molecular, cellular, and whole organ aspects of cardiac remodeling in a rat model of volume overload. His general pediatrics residency training took place at Cincinnati Children’s Hospital Medical Center from 2006-2009, as did his Pediatric Cardiology fellowship training from 2009-2012 and advanced fellowship in Pediatric Heart Failure/Transplant from 2012-2013. His clinical and research interests focus on heart failure, cardiomyopathy, cardiac transplantation, and mechanical circulatory support.
BS: Wichita State University, Wichita, KS, 1996.
PhD: University of Alabama at Birmingham, Birmingham, AL, 2004.
MD: University of Alabama at Birmingham, Birmingham, AL, 2005.
Residency: Pediatrics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2006-2009.
Fellowship: Pediatric Cardiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2009-2012.
Advanced Fellowship: Pediatric Heart Failure/Transplant, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2012-2013.
Certification: American Board of Pediatrics, 2010; American Board of Pediatrics, Sub-board of Pediatric Cardiology, 2012.
Ryan TD, Gupta D, Gupta A, Goldenberg P, Taylor MD, Lorts A, Jefferies JL. Cardiomyopathy in a Patient with Russell-Silver Syndrome. Cardiovasc Path. 2013 Sep 24. Epub ahead of print.
Ryan TD, Taylor MD, Wojciech M, Cripe LH, Pratt J, King EC, Lao K, Grenier MA, Jefferies JL, Benson DW, Hor KH. Abnormal circumferential strain is present in young Duchenne muscular dystrophy patients. Pediatric Cardiol. 2013 Jun;34(5):1159-65.
Ryan TD, Ware SM, Lucky AW, Towbin JA, Jefferies JL, Hinton RB. Left ventricular noncompaction cardiomyopathy and aortopathy in a patient with recessive dystrophic epidermolysis bullosa. Circ Heart Fail. 2012 Sep 1;5(5):e81-2.
Ryan TD, Rothstein EC, Aban I, Tallaj JA, Husain A, Lucchesi PA, Dell'Italia LJ. Left ventricular eccentric remodeling and matrix loss are mediated by bradykinin and precede cardiomyocyte elongation in rats with volume overload. J Am Coll Cardiol. 2007 Feb 20;49(7):811-21.
Ryan TD, Dimmitt RA, Tubbs RS, Roberts OA, Choi H, Loukas M, Blount JP. Contribution of surgical evacuation of a large subgaleal hematoma to the resolution of severe conjugated hyperbilirubinemia in a neonate. Case report. J Neurosurg. 2007 Feb;106(2 Suppl):131-3.
David S. Spar, MD Pediatric Electrophysiologist, Heart Institute, Pediatric Cardiology
Pediatric Electrophysiologist, Heart Institute, Pediatric Cardiology
Pediatric electrophysiology and pacing
MD: University of Vermont College of Medicine, Burlington, VT, 2005.
Residency: Pediatrics, Yale-New Haven Children’s Hospital, New Haven, CT, 2008.
Fellowship: Pediatric Cardiology, Morgan Stanley Children’s Hospital, Columbia University, New York, NY, 2011.
Pediatric Electrophysiology Fellowship: Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2012.
Spar DS, Anderson JB, Palumbo JS, Kukreja KU, Czosek RJ. Symptomatic Upper-Extremity Deep Venous Thrombosis After Pacemaker Placement in a Pediatric Patient: How to Treat?Pediatr Cardiol. 2012 May 23.
Spar DS, Silver ES, Hordof AJ, Liberman L. Relation of the utility of exercise testing for risk assessment in pediatric patients with ventricular preexcitation to pathway location. Am J Cardiol. 2012 Apr 1;109(7):1011-4.
Spar DS, Silver ES, Hordof AJ, Torres A, Liberman L. Coronary artery spasm during radiofrequency ablation of a left lateral accessory pathway. Pediatr Cardiol. 2010 Jul;31(5):724-7.
Erdem SR, Broxson CS, Erdem A, Spar DS, Williams RT, Tümer N. The age-related discrepancy in the effect of neuropeptide Y on select catecholamine biosynthetic enzymes in the adrenal medulla and hypothalamus in rats. Neuropharmacology. 2002 Dec;43(8):1280-8.
Spar D, Macknin M. Use of letters and phone calls to encourage preparticipation Special Olympics physical examinations to be done in a medical home: a randomized, controlled trial. Clin Pediatr (Phila). 2001 Dec;40(12):685-7.
Shelly L. Stark, MSN, APRN, CPNP-AC Acute Care Pediatric Nurse Practitioner, Heart Failure/Cardiomyopathy/Transplant, Heart Institute
Acute Care Pediatric Nurse Practitioner, Heart Failure/Cardiomyopathy/Transplant, Heart Institute
Pediatric cardiology; cardiomyopathy; heart failure; heart transplant.
Pediatric cardiac transplant; heart failure
RN Co-Op Program: Cincinnati Children's Hospital Medical Center (Transitional Care Center, Cardiac Intensive Care Unit), Cincinnati, OH, 2008-2009.
BSN: Nursing, University of Cincinnati, Cincinnati, OH, 2009.
RN: Cardiac Intensive Care Unit, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2009-2013
MSN: Acute Care Pediatric Nurse Practitioner, University of Cincinnati, Cincinnati, OH, 2013.
CPNP-AC: Pediatric Nursing Certification Board, 2013.
APRN: Heart Failure/Cardiomyopathy/Transplant Services, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2013.
BreAnn Taylor, PharmD, BCPS Clinical Pharmacy Specialist, Outpatient Cardiology, Division of Pharmacy
Jeffrey A. Towbin, MD, FAAP, FACC, FAHA Executive Co-Director, Heart Institute; Chief, Pediatric Cardiology
Executive Co-Director, Heart Institute; Chief, Pediatric Cardiology
Director, Heart Institute Diagnostic Laboratory
BS: Biology, University of Cincinnati, 1974.MS: Cell Biology, University of Cincinnati, 1977.MD: University of Cincinnati, 1982.
Residency: Pediatrics, Cincinnati Children's Hospital Medical Center, 1985.
Fellowship: Pediatric Cardiology, Baylor College of Medicine, Texas Children's Hospital, 1989.
McBride KL, Zender GA, Fitzgerald-Butt SM, Seagraves NJ, Fernbach SD, Zapata G, Lewin M, Towbin JA, Belmont JW. Association of common variants in ERBB4 with congenital left ventricular outflow tract obstruction defects. Birth Defects Res A Clin Mol Teratol. 2011 Mar;91(3):162-8.
Fakhro KA, Choi M, Ware SM, Belmont JW, Towbin JA, Lifton RP, Khokha MK, Brueckner M. Rare copy number variations in congenital heart disease patients identify unique genes in left-right patterning. Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):2915-20.
Goldenberg I, Horr S, Moss AJ, Lopes CM, Barsheshet A, McNitt S, Zareba W, Andrews ML, Robinson JL, Locati EH, Ackerman MJ, Benhorin J, Kaufman ES, Napolitano C, Platonov PG, Priori SG, Qi M, Schwartz PJ, Shimizu W, Towbin JA, Vincent GM, Wilde AA, Zhang L. Risk for life-threatening cardiac events in patients with genotype-confirmed long-QT syndrome and normal-range corrected QT intervals. J Am Coll Cardiol. 2010 Dec 28;57(1):51-9.
Towbin JA, Ware SM, Jefferies JL. Heart transplants in pediatric patients: viral infection as a loss predictor. Future Cardiol. 2010 Nov;6(6):735-41.
Foerster SR, Canter CE, Cinar A, Sleeper LA, Webber SA, Pahl E, Kantor PF, Alvarez JA, Colan SD, Jefferies JL, Lamour JM, Margossian R, Messere JE, Rusconi PG, Shaddy RE, Towbin JA, Wilkinson JD, Lipshultz SE. Ventricular remodeling and survival are more favorable for myocarditis than for idiopathic dilated cardiomyopathy in childhood: an outcomes study from the Pediatric Cardiomyopathy Registry. Circ Heart Fail. 2010 Nov 1;3(6):689-97.
Purevjav E, Varela J, Morgado M, Kearney DL, Li H, Taylor MD, Arimura T, Moncman CL, McKenna W, Murphy RT, Labeit S, Vatta M, Bowles NE, Kimura A, Boriek AM, Towbin JA. Nebulette mutations are associated with dilated cardiomyopathy and endocardial fibroelastosis. J Am Coll Cardiol. 2010 Oct 26;56(18):1493-502. Towbin JA. Left ventricular noncompaction: a new form of heart failure. Heart Fail Clin. 2010 Oct;6(4):453-69 Towbin JA. Preface: Heart failure in children. Heart Fail Clin. 2010 Oct;6(4):xvii-iii.
Wilkinson JD, Landy DC, Colan SD, Towbin JA, Sleeper LA, Orav EJ, Cox GF, Canter CE, Hsu DT, Webber SA, Lipshultz SE. The pediatric cardiomyopathy registry and heart failure: key results from the first 15 years. Heart Fail Clin. 2010 Oct;6(4):401-13 Towbin JA. Hypertrophic cardiomyopathy. Pacing Clin Electrophysiol. 2009 Jul;32 Suppl 2:S23-31.
Ivan Wilmot, MD Heart Failure, Transplant, VAD Physician
Heart failure, transplantation, and mechanical circulatory support.
Care of children with advanced heart failure requiring mechanical circulatory support bridge to transplant; quality of life in children with heart failure, transplant and mechanical circulatory support (MCS); advanced strain imaging in evaluation of ventricular function in pediatric heart transplant patients.
Ivan Wilmot, MD, graduated summa cum laude from Louisiana State University with a Bachelor's of Science in zoology.
In 1998 he began medical school at Emory University. His general pediatrics residency training took place at the Emory Affiliated Hospitals from 2002 to 2006. He completed his pediatric cardiology fellowship training from 2006 to 2009, and advanced fellowship in heart failure and transplant from 2009 to 2010.
His clinical and research interests focus on heart failure, cardiac transplantation and mechanical circulatory support (MCS).
BS: Louisiana State University, 1998.
MD: Emory University School of Medicine, Atlanta, GA, 2002.
Residency: Emory Affiliated Hospitals, Atlanta, GA, 2005; Chief Resident: Emory Affiliated Hospitals, Atlanta, GA, 2006.
Fellowship: Baylor College of Medicine, Texas Children’s Hospital, Houston, TX, 2009.
Advanced Fellowship: Heart Failure and Transplant, Baylor College of Medicine, Texas Children’s Hospital, Houston, TX, 2010.
Certification: American Board of Pediatrics; American Board of Pediatrics Sub-board of Pediatric Cardiology.
Stapleton GE, Wilmot I, Suh EJ. Cardiac catheterisation of patients with common arterial trunk and transposition of the great arteries. Cardiol Young. 2012 Dec:22(6), 687–690.
Dadlani GH, Braley K, Perez-Colon E, Stapleton G, Crawford M, Turpin D, Wilmot I, Freire G, Decker J, Martinez R. Long-term management of patients with hypoplastic left heart syndrome: the diagnostic approach at All Children's Hospital. Cardiol Young. 2011 Dec:21 Suppl 2, 80–87.
Asante-Korang A, Jacobs JP, Ringewald J, Carapellucci J, Rosenberg K, McKenna D, McCormack J, Wilmot I, Gjeldum A, Lopez-Cepero M, Sleasman J. Management of children undergoing cardiac transplantation with high Panel Reactive Antibodies. Cardiol Young. 2011 Dec:21 Suppl 2, 124–132.
Wilmot I, Morales DL, Price JF, Rossano JW, Kim JJ, Decker JA, McGarry MC, Denfield SW, Dreyer, WJ, Towbin JA, Jeffries JL. Effectiveness of mechanical circulatory support in children with acute fulminant and persistent myocarditis. J Card Fail. 2011 June:17(6), 487–494.
Perez-Colon E, Dadlani GH, Wilmot I, Miller M. Mesalamine-induced myocarditis and coronary vasculitis in a pediatric ulcerative colitis patient: a case report. Case Rep Peditr. 2011; 524364.
Sharef S, Coleman R, Rivenes S, Wilmot I, Altman C, Madden-Fuentes R, Salazar J. Stentless xenograft implantation in aortic position in a 7-year-old girl. Tex Heart Inst J. 2010; 37(3), 347–349.
Wilmot I, Kanter KR, Vincent RN, Berg AM, Mahle WT. OKT3 treatment in refractory pediatric heart transplant rejection. J Heart Lung Transplant. 2005 Nov;24(11):1793-7.
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