Clinical Laboratories

  • Medical and Scientific Directors of Labs

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    Medical Director of Core Labs

    A photo of Paul Steele.

    Paul E. Steele, MD
    Medical Director, Clinical Laboratory

    513-636-4898

    paul.steele@cchmc.org

    Paul E. Steele, MD

    Medical Director, Clinical Laboratory

    Associate Professor, UC Department of Pediatrics

    Phone: 513-636-4898

    Fax: 513-636-8850

    Email: paul.steele@cchmc.org

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    Specialties

    Molecular pathology; human endogenous retroviral envelope expression

    Biography

    Paul E. Steele, MD, is medical director of the clinical laboratory at Cincinnati Children's Hospital Medical Center, arriving in 1999. He came to Children's Hospital Medical Center of Cincinnati from University Hospital of Cincinnati, where he was a member of the laboratory medicine staff for 11 years.

    Dr. Steele's background includes general laboratory directorship, as he was Medical Director of University Hospital's Immediate Response Laboratory for over two years before coming to Cincinnati Children's.

    Dr. Steele has also served as medical director of Diagnostic Immunology since arriving at University Hospital. In this position, he was involved in humoral immunology, including infectious disease serology, autoimmune testing, protein characterization, and allergy testing; he was also involved in flow cytometry, including transplantation, stem cell and HIV monitoring, as well as evaluation and monitoring of hematopoietic neoplasms.

    Dr. Steele has also been involved in molecular pathology. At University Hospital, he put in place a molecular diagnostics laboratory which provided molecular genetic detection of lymphoid clonality as well as chromosomal translocation in chronic myelocytic leukemia. At Children's Hospital Medical Center of Cincinnati, he has become a participant in overseeing the molecular genetic testing for infectious disease.

    Dr. Steele's research interests include the evaluation of human endogenous retroviral sequences and their role in human pathology. This work is an outgrowth of studies he began as a postdoctoral fellow at the National Institutes of Health.

    Specifically, Dr. Steele has created antisera to a biosynthetic fusion protein containing a portion of a human endogenous retroviral envelope gene that encodes a putative immunosuppressive protein. This antisera detects a human protein which is the subject of Dr. Steele's study.

    Education and Training

    MD: University of Missouri, Kansas City, 1978.

    Residency: Anatomic Pathology, Massachusetts General Hospital, Boston 1978-81; Clinical Pathology, Barnes Hospital, St. Louis, MO, 1984-86.

    Fellowships: Basic science fellowship, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD, 1981-84.

    Certification: Anatomic and Clinical Pathology, 1987.

    Directors of Specialty Labs

    A photo of Prasad Devarajan.

    Prasad Devarajan, MD
    Director, Division of Nephrology and Hypertension

    513-636-4531

    prasad.devarajan@cchmc.org

    Prasad Devarajan, MD

    Director, Division of Nephrology and Hypertension

    Medical Director, Stone Center

    Director, Nephrology and Hypertension Clinical Laboratory

    Louise M. Williams Endowed Chair

    Professor, UC Department of Pediatrics

    Phone: 513-636-4531

    Fax: 513-636-7407

    Email: prasad.devarajan@cchmc.org

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    Specialties

    Clinical specialties: Acute kidney injury, nephrotic syndrome, kidney stones

    Visit the Devarajan Lab.

    Education and Training

    Premedical Studies: Bombay University, India, 1979. 

    MD: Bombay University, India, 1985.

    Publications

    View PubMed Publications
    A photo of Larry Dolan.

    Lawrence M. Dolan, MD
    Director, Division of Endocrinology

    513-636-4744

    Lawrence M. Dolan, MD

    Director, Division of Endocrinology

    Director, Endocrinology Clinical Laboratory

    Professor, UC Department of Pediatrics

    Phone: 513-636-4744

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    Specialties

    Epidemiology and genetics of obesity; insulin resistance; abnormal carbohydrate metabolism; diabetes and their relationships to the development and progression of cardiovascular disease 

    Biography

    Lawrence M. Dolan, MD, is board-certified in pediatrics and pediatric endocrinology. He has been on the faculty of Cincinnati Children's Hospital Medical Center in the Department of Pediatrics for the University of Cincinnati College of Medicine since 1983.

    Dr. Dolan is a professor of pediatrics in the Division of Endocrinology. His research focuses on the epidemiology and genetics of obesity, insulin resistance, abnormal carbohydrate metabolism, diabetes and their relationships to the development and progression of cardiovascular disease.

    Dr. Dolan received his bachelor of science degree from the University of San Francisco. He received his doctor of medicine degree from the University of California at Los Angeles.

    Dr. Dolan completed his pediatric internship and residency at the University of Minnesota. He also served as chief resident. He obtained fellowship training in pediatric endocrinology at the University of Virginia.

    Education and Training

    BS: University of San Francisco, San Francisco, CA, 1971.

    MD: University of California at Los Angeles, Los Angeles, CA, 1976.

    Residency: University of Minnesota, Minneapolis, MN, 1976 to 1979. Chief Resident, 1979.

    Fellowship: University of Virginia, Charlottesville, VA.

    Certification: Pediatrics, 1982; Pediatric Endocrinology, 1983.

    Publications

    View PubMed Publications

    Grants

    Understanding Social Status Input on Adolescent Health. Co-Principal Investigator. National Institutes of Health. Dec 2007 - Nov 2011. #RO1HD41527.

    SEARCH Nutritional Ancillary Study of the SEARCH for Diabetes in Youth Study. Co-Principal Investigator. National Institutes of Health. Feb 2008 - Jan 2012. #RO1DK077949.

    SEARCH 3: Cohort Study to assess the incidence of acute and chronic diabetes related complications. Principal Investigator. National Institutes of Health. Sep 2010 - Oct 2015. #1U18DP002709.

    Accelerated Cardiovascular Aging in Youth. Co-Principal Investigator. National Institutes of Health. Jan 2011 -Dec 2015. #R01-105591.

    A photo of Lisa Filipovich.

    Alexandra (Lisa) H. Filipovich, MD
    Ralph J. Stolle Chair, Clinical Immunology

    513-803-3218

    lisa.filipovich@cchmc.org

    Alexandra (Lisa) H. Filipovich, MD

    Ralph J. Stolle Chair, Clinical Immunology

    Director, Immune Deficiency and Histiocytosis Program

    Medical Director, Diagnostic Immunology Laboratory

    Professor, UC Department of Pediatrics

    Phone: 513-803-3218

    Fax: 513-803-1969

    Email: lisa.filipovich@cchmc.org

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    Specialties

    Clinical Interests

    Primary immunodeficiencies; BMT for primary immunodeficiencies; hemophagocytic lymphocytosis; post-BMT immune reconstruction

    Research Interests

    Biology and genetics of hemophagocytic lymphohistiocytosis; investigation of hematopoietic cell transplantation for genetic immunodeficiencies; immunoreconstitution following pediatric stem cell transplantation

    Biography

    Lisa Filipovich, MD, began her career at the University of Minnesota where she received her medical degree in 1974 and completed fellowships in both immunopathology and pediatric immunology. She became a professor of pediatrics and served for 10 years as the head of the Division of Immunology at the University of Minnesota Medical School. Dr. Filipovich came to Cincinnati Children’s in 1996. She is currently the Ralph J. Stolle Chair in Clinical Immunology and the director of the Immune Deficiency and Histiocytosis program. She also serves as the medical director of the Diagnostic Immunology Laboratory at Cincinnati Children’s.

    Dr. Filipovich has a special interest in histiocytic disorders, especially hemophagocytic lymphohistiocytosis (HLH). Other interests include bone marrow transplant for primary immune deficiencies and post-BMT immune reconstitution. She serves as president of the Histiocyte Society, an international group of more than 200 physicians and scientists who are committed to improving the lives of patients with histiocytosis through research.

    Education and Training

    MD: University of Minnesota, Minneapolis, MN, 1974.

    Residency: University of Minnesota Hospitals, Minneapolis, MN 1975-1978.

    Fellowship: Immunopathology, Departments of Pediatrics, Laboratory Medicine and Pathology, University of Minnesota 1978-1979.

    Fellowship: Pediatric Immunology, Department of Pediatrics, University of Minnesota 1979-1980.

    Certification: Pediatrics, 1980.

    Publications

    View PubMed Publications

    Grants

    Gene Therapy for SCID-X1 Using Self-Inactivating Gamma. Principal Investigator. National Institutes of Health. Sep 2010-Aug 2015. #U01 AI 087628.

    Rare Diseases Clinical Consortia for the Rare Diseases. Principal Investigator. National Institutes of Health. Sep 2009-Aug 2014. #U54 AI 082973.

    Hypoxia and potassium channel activity in T Lymphocytes. Principal Investigator. National Institutes of Health. Jun 2009-Jun 2014. #R01 CA 095286.

    A photo of Ralph A. Gruppo.

    Ralph A. Gruppo, MD
    Director, Comprehensive Hemophilia and Thrombosis Center

    513-636-4269

    ralph.gruppo@cchmc.org

    Ralph A. Gruppo, MD

    Director, Comprehensive Hemophilia and Thrombosis Center

    Director, Research Coagulation Laboratory

    Director, Special Hemostasis & Thrombosis Laboratory

    Professor, UC Department of Pediatrics

    Phone: 513-636-4269

    Fax: 513-636-5845

    Email: ralph.gruppo@cchmc.org

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    Specialties

    Coagulation; hemophilia; thrombosis

    Education and Training

    MD: Johns Hopkins Medical School, Baltimore, MD, 1967.

    Residency: Children's Hospital Medical Center, Cincinnati, Ohio; Johns Hopkins School of Medicine, Baltimore, MD, 1970.

    Fellowship: Children's Hospital Medical Center, Cincinnati, OH, 1974.

    Certification: Pediatrics, 1975; Pediatric Hematology/Oncology, 1976.

    Publications

    View PubMed Publications

    A photo of Punam Malik, MD.

    Punam Malik, MD
    Director, Comprehensive Sickle Cell Program

    513-636-1333

    punam.malik@cchmc.org

    Punam Malik, MD

    Director, Comprehensive Sickle Cell Program

    Director, Translational Trials Development and Support Laboratory

    Program Leader, Molecular and Gene Therapy Program

    Professor, UC Department of Pediatrics

    Phone: 513-636-1333

    Fax: 513-636-1330

    Email: punam.malik@cchmc.org

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    Education and Training

    MBBS: University of Delhi, New Delhi, India, 1985.

    MD: University of Delhi, New Delhi, India, 1989.

    MS: University of Maryland, Baltimore, MD, 1991.

    Fellowship: Children's Hospital Los Angeles, University of Southern California, 1995.

    Publications

    View PubMed Publications
    A photo of Mark Mitsnefes.

    Mark M. Mitsnefes, MD, MS
    Director, Clinical and Translational Research Center

    513-636-0125

    mark.mitsnefes@cchmc.org

    Mark M. Mitsnefes, MD, MS

    Director, Clinical and Translational Research Center

    Pediatric Nephrologist

    Professor, UC Department of Pediatrics

    Phone: 513-636-0125

    Fax: 513-636-7407

    Email: mark.mitsnefes@cchmc.org

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    Specialties

    Nephrology with focus on chronic kidney disease and hypertension

    Biography

    Mark Mitsnefes, MD, MS, is an established clinical investigator with expertise in the area of understanding the development of risk factors for cardiovascular disease in children with chronic kidney disease. The long-term goal of his research is to define biologic targets for interventions to prevent and slow progression of cardiovascular disease in children with chronic kidney disease.

    Dr. Misnefes has received numerous awards, including the Proctor Scolar Award (Cincinnati Children's Research Foundation), the Pediatrician Scientist Award (Children's Health Research Center, NIH), the Clinical Scientist Award (National Kidney Foundation), and has been ranked as one of the Best Doctors in America, 2007-2011.

    Education and Training

    MD: Gorky Medical Institute, Gorky, Russia, 1985.

    Residency: Miami Children's Hospital, Miami, Florida, 1997.

    Fellowship: Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, 2000.

    MS: Epidemiology and Biostatistics, University of Cincinnati, Cincinnati, Ohio, 2001.

    Certifications: Educational Commission for Foreign Medical Graduates (ECFMG), 1995; Pediatrics, 1996; Pediatric Nephrology, 2001, 2008.

    Publications

    View PubMed Publications

    Grants

    Adiponectin and Cardiovascular Disease in the CKiD Children. Principal Investigator. National Institutes of Health. 2007 - 2011. #R01 DK076957.

    Modify Dietary Behavior in Adolescents with Elevated Blood Pressure. Co-investigator. National Institutes of Health. 2007 - 2012.

    Prospective study of chronic kidney disease in children. Co-investigator, Co-chair of the Cardiovascular Committee. National Institutes of Health. 2003 - 2013. #U01 DK-03-012.

    Cardiovascular disease in children with CKD. Principal Investigator. National Institutes of Health. 2011 - 2016. #K24 DK090070-01.


    A photo of Joel E. Mortensen.

    Joel E. Mortensen, PhD
    Director, Diagnostic Infectious Diseases Testing Laboratory (Microbiology and Virology)

    513-636-5310

    joel.mortensen@cchmc.org

    Joel E. Mortensen, PhD

    Director, Diagnostic Infectious Diseases Testing Laboratory (Microbiology and Virology)

    Associate Professor, UC Department of Pediatrics

    Phone: 513-636-5310

    Fax: 513-636-8850

    Email: joel.mortensen@cchmc.org

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    Specialties

    Research Interests

    Dr. Mortensen's current research focus is antimicrobial susceptibility testing of fastidious pediatric pathogens.

    Clinical Interests

    Dr. Mortensen is a career academic clinical microbiologist in the Department of Pathology and Laboratory Medicine at Cincinnati Children's since 1991. Beyond providing consultation to the medical staff in Clinical Microbiology, his clinical interests include the application of rapid testing methods into the clinical microbiology laboratory and outpatient settings and LEAN manufacturing processes applied to Clinical Microbiology. His collaborations with faculty and fellows have resulted in more than 100 peer-reviewed publications, case studies and text chapters.

    Education and Training

    BS: Mount Union College, Alliance, Ohio, 1979.

    PhD: The Ohio State University, Columbus, Ohio, 1983.

    Residency: Accredited Postdoctoral Residence Program in Medical and Public Health Microbiology; Baylor College of Medicine, University of Texas Medical School, Pathology, Houston, Texas 1983-85.

    Certification: Certified Laboratory Consultant, American Medical Technologists, 1998.

    Publications

    View PubMed Publications
    A photo of Charles Quinn, MD.

    Charles T. Quinn, MD, MS
    Director, Hematology Clinical and Translational Research

    513-636-4266

    charles.quinn@cchmc.org

    Charles T. Quinn, MD, MS

    Director, Hematology Clinical and Translational Research

    Director, Hemoglobinopathy Laboratory

    Associate Professor, UC Department of Pediatrics

    Phone: 513-636-4266

    Fax: 513-636-5845

    Email: charles.quinn@cchmc.org

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    Specialties

    Clinical Interests

    Sickle cell disease; thalassemia; hemoglobinopathies; anemia; autoimmune hemolytic anemia; disorders of red blood cells; iron overload and iron chelation; chronic transfusion therapy; immune thrombocytopenia (ITP); neutropenia; stroke

    Research Interests

    Epidemiology, pathophysiology, treatment and prevention of brain injury (structural and cognitive) in sickle cell disease; measurement of red blood cell turnover in sickle cell disease; identification and treatment of cardiomyopathy and nephropathy in sickle cell disease; treatment and prevention of pain (VOC) in sickle cell disease; MRI methods of iron quantitation; new agents for immune thrombocytopenia (ITP)

    Biography

    Dr. Quinn’s main interests and expertise are in patient-oriented and translational research in sickle cell disease and thalassemia. His formal clinical and translational research training has included: (1) the NIH-K30 Curriculum in Patient-Oriented Research; (2) the Clinical Research Training Institute of the American Society of Hematology; (3) the NIH-K12/KL2 Clinical Scholars Program; and (4) a master’s degree in clinical sciences. Dr. Quinn is a member of the Editorial Board for Pediatric Blood and Cancer and the Board of Contributing Editors for The Hematologist. Dr. Quinn is on the Medical Advisory Board for the Cooley’s Anemia Foundation, and he is a member of the Committee on Educational Affairs of the American Society of Hematology. Locally, he is the medical director of the Ohio Department of Health Regional Sickle Cell Services Program – Region 1.

    Education and Training

    MD:  University of Texas Southwestern Medical Center, Dallas, TX, 1994.

    MS:  University of Texas Southwestern Medical Center, Dallas, TX, 2008.

    Residency & Chief Residency: Children's Medical Center Dallas, Dallas, TX; University of Texas Southwestern Medical Center, Dallas, TX, 1998.

    Fellowship:  Children's Medical Center Dallas, Dallas, TX; University of Texas Southwestern Medical Center, Dallas, TX, 2001.

    Certifications: Pediatrics, 1998; Pediatric Hematology-Oncology, 2002.

    Publications

    View PubMed Publications

    Grants

    Measuring RBC Turnover by Stable Isotope Labeling in SCD. Principle Investigator. CCTST T1 Pilot Grant (CTSA). Jun 2012 - May 2013.

    Hydroxyurea to prevent CNS complications of sickle cell disease in children. Co-Investigator. National Institutes of Health (NHLBI). Sep 2011 - Jul 2013. # R34HL108756.

    A Controlled Clinical Trial of Regadenoson in Sickle Cell Anemia. Co-Investigator. National Institutes of Health (NHLBI). Apr 2012 - Mar 2017. #P50HL110790.


    A photo of Teresa Smolarek.

    Teresa Smolarek, PhD
    Director, Cytogenetics Laboratory

    513-636-7221

    teresa.smolarek@cchmc.org

    Teresa Smolarek, PhD

    Director, Cytogenetics Laboratory

    Associate Professor, UC Department of Pediatrics

    Phone: 513-636-7221

    Fax: 513-636-4373

    Email: teresa.smolarek@cchmc.org

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    Specialties

    Genetic basis of pulmonary lymphangioleiomyomatosis (LAM); cancer genetics; clinical cytogenetics

    Education and Training

    PhD: Medical Genetics, Indiana University School of Medicine, 1995.

    Certification: American Board of Medical Genetics, Clinical Cytogenetics, 2002; Clinical Molecular Genetics, 2005.

    Publications

    View PubMed Publications.
    A photo of Peter Tang.

    Peter H. Tang, PhD
    Director, Special Chemistry

    513-636-3357

    peter.tang@cchmc.org

    Peter H. Tang, PhD

    Director, Special Chemistry

    Clinical Chemist

    Assistant Professor, UC Department of Pediatrics

    Phone: 513-636-3357

    Fax: 513-636-8850

    Email: peter.tang@cchmc.org

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    Specialties

    Clinical Interests

    In vitro diagnostics; disease monitoring procedures

    Research Interests

    Mitochondrial dysfunction; metabolic disorders; neurodegenerative diseases; hemoglobin disorders; neurogenesis; and therapeutic drug monitoring

    Education and Training

    PhD: Analytical Chemistry, University of Cincinnati, Cincinnati, OH, 1990.

    MS: Biochemistry, Northeast Louisiana University, Monroe, LA, 1985.

    BS: Pharmacy, Taipei Medical College, Taipei, Taiwan, 1978.

    Publications

    View PubMed Publications

    A photo of Jeffrey Towbin.

    Jeffrey A. Towbin, MD, FAAP, FACC, FAHA
    Executive Co-Director, Heart Institute; Chief, Pediatric Cardiology

    513-636-3049

    jeffrey.towbin@cchmc.org

    Jeffrey A. Towbin, MD, FAAP, FACC, FAHA

    Executive Co-Director, Heart Institute; Chief, Pediatric Cardiology

    Director, Heart Institute Diagnostic Laboratory

    Phone: 513-636-3049

    Email: jeffrey.towbin@cchmc.org

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    Education and Training

    BS: Biology, University of Cincinnati, 1974.

    MS: Cell Biology, University of Cincinnati, 1977.

    MD: University of Cincinnati, 1982.

    Residency: Pediatrics, Cincinnati Children's Hospital Medical Center, 1985.

    Fellowship: Pediatric Cardiology, Baylor College of Medicine, Texas Children's Hospital, 1989.

    Publications

    View PubMed Publications

    Grants

    Pediatric Cardiomyopathy Registry. Sub-Contract Principal Investigator. National Heart, Lung and Blood Institute. Sep 2006 - Aug 2011. #RO1 HL53392-06A1.
    A photo of David Witte.

    David P. Witte, MD
    Director, Pathology

    513-636-4261

    david.witte@cchmc.org

    David P. Witte, MD

    Director, Pathology

    Director, Mass Spectrometry Laboratory

    Professor, UC Department of Pathology & Laboratory Medicine

    Phone: 513-636-4261

    Fax: 513-636-3924

    Email: david.witte@cchmc.org

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    Specialties

    Molecular pathology; pediatric renal pathology

    Molecular/Developmental Biology

    Education and Training

    MD: University of Cincinnati, Cincinnati, Ohio, 1979.

    Residency: Pediatrics, Washington University, St. Louis, Mo., 1979-1980; Pathology, Washington University, St. Louis, Mo., 1980-1984.

    Fellowship: Pathology, Children's Hospital Medical Center, Cincinnati, Ohio, 1984-1986; Research Scholar, Pathology, Children's Hospital Medical Center, Cincinnati, Ohio, 1986-1989.

    Certification: Anatomic Pathology, American Board of Pathology, 1985; Pediatric Pathology, American Board of Pathology, 1991.


    A photo of Kejian Zhang.

    Kejian Zhang, MD, MBA
    Director, Molecular Genetics Laboratory

    513-636-0121

    kejian.zhang@cchmc.org

    Kejian Zhang, MD, MBA

    Director, Molecular Genetics Laboratory

    Associate Professor, UC Department of Pediatrics

    Phone: 513-636-0121

    Fax: 513-636-2261

    Email: kejian.zhang@cchmc.org

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    Specialties

    Clinical Interests

    Molecular genetics diagnosis of inherited immunodeficiency disorders and other genetic conditions

    Research Interests

    Molecular defects and molecular diagnosis of primary immunodeficiency diseases; Genetic aspects of predictive personalized medicine (pharmacogenetics)

    Education and Training

    MD: Tianjin Medical University, Tianjin, China, 1993

    MBA: University of Cincinnati, College of Business Administration, 2001

    Residency: Gong'an Hospital, Tianjin, China, 1993-1995

    Fellowship: Clinical Molecular Genetics Fellow, Division of Human Genetics, Cincinnati Children's Hospital, 2002-2004

    Publications

    View PubMed Publications

    Grants

    Macrophage Activation Syndrome Biomarkers in Systemic Juvenile Idiopathic Arthritis. Co-investigator. National Institute of Arthritis, Musculoskeletal and Skin Diseases. Aug 2007 - Dec 2012.

    MUNC13-4 gene Polymorphisms in Macrophage Activation syndrome and Systemic Juvenile Idiopathic Arthritis. Co-Investigator. National Institute of Health. Sept 2011 - Aug 2016.