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Showing 1 - 10 of 16 records.
This randomized phase II trial is studying how well giving temozolomide and irinotecan hydrochloride together with or without bevacizumab works in treating young patients with recurrent or refractory medulloblastoma or CNS primitive neuroectodermal tumors....More
This randomized phase II/III trial is studying vorinostat, temozolomide, or bevacizumab to see how well they work compared with each other when given together with radiation therapy followed by bevacizumab and temozolomide in treating young patients with newly diagnosed high-grade glioma. ...More
Primary Estimate the maximum-tolerated dose and/or recommended phase II dose of obatoclax mesylate in combination with vincristine sulfate, doxorubicin hydrochloride, and dexrazoxane hydrochloride in pediatric patients with refractory solid tumors Define and describe the toxicities of obatoclax mes...More
To estimate the sustained objective response rates [complete response (CR) plus partial response (PR)] to lapatinib 900 mg/m2/dose twice a day, bevacizumab 10 mg/kg IV every 2 weeks in children with recurrent or refractory ependymoma. ...More
Primary To determine the toxicities and feasibility of the proposed treatment regimen in patients with high-grade glioma and diffuse intrinsic brainstem glioma Secondary To determine the one year EFS, median PFS and median OS in newly diagnosed patients with high-grade glioma treated with radiother...More
Primary 1. To estimate the maximum tolerated dose (MTD) and recommended phase II dose of MK-0752 administered for 3 consecutive days of every 7 days in 28 day courses to young patients with recurrent or refractory CNS malignancies. 2. To estimate the MTD and recommend a phase II dose of MK0752 admi...More
This phase II trial is studying how well combination chemotherapy works in treating patients with stage III or stage IV malignant peripheral nerve sheath tumors. ...More
phase II trial is studying how well GDC-0449 works in treating younger patients
with recurrent or refractory medulloblastoma. GDC-0449 may slow the growth of
This research study is studying biomarkers in blood samples from young patients with newly diagnosed brain tumors undergoing standard radiation therapy and chemotherapy...More
This phase II trial studies how well chemotherapy and radiation therapy work in treating younger patients with newly diagnosed central nervous system germ cell tumors....More
Cincinnati Children’s is involved in research because it is very important to understanding diseases and developing ways to prevent and treat health problems in children, as well as adults. Learn more about how you can help. Contact us at firstname.lastname@example.org or 513-636-0098. Or, enroll in our database to be notified about future studies by completing an online sign up form.
The Office for Clinical and Translational Research at Cincinnati Children’s provides sponsors and investigators with comprehensive support services, research tools, personnel and facilities to conduct or facilitate pediatric and adult clinical research studies. Contact us at OCTR@cchmc.org or 513-636-0314.
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