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Showing 1 - 10 of 16 records.
This randomized phase II trial is studying how well giving temozolomide and irinotecan hydrochloride together with or without bevacizumab works in treating young patients with recurrent or refractory medulloblastoma or CNS primitive neuroectodermal tumors....More
This randomized phase II/III trial is studying vorinostat, temozolomide, or bevacizumab to see how well they work compared with each other when given together with radiation therapy followed by bevacizumab and temozolomide in treating young patients with newly diagnosed high-grade glioma. ...More
Primary Estimate the maximum-tolerated dose and/or recommended phase II dose of obatoclax mesylate in combination with vincristine sulfate, doxorubicin hydrochloride, and dexrazoxane hydrochloride in pediatric patients with refractory solid tumors Define and describe the toxicities of obatoclax mes...More
To estimate the sustained objective response rates [complete response (CR) plus partial response (PR)] to lapatinib 900 mg/m2/dose twice a day, bevacizumab 10 mg/kg IV every 2 weeks in children with recurrent or refractory ependymoma. ...More
Primary To determine the toxicities and feasibility of the proposed treatment regimen in patients with high-grade glioma and diffuse intrinsic brainstem glioma Secondary To determine the one year EFS, median PFS and median OS in newly diagnosed patients with high-grade glioma treated with radiother...More
Primary 1. To estimate the maximum tolerated dose (MTD) and recommended phase II dose of MK-0752 administered for 3 consecutive days of every 7 days in 28 day courses to young patients with recurrent or refractory CNS malignancies. 2. To estimate the MTD and recommend a phase II dose of MK0752 admi...More
This phase II trial is studying how well combination chemotherapy works in treating patients with stage III or stage IV malignant peripheral nerve sheath tumors. ...More
This phase I/II trial is studying the side effects and best dose of crizotinib and to see how well it works in treating young patients with relapsed or refractory solid tumors or anaplastic large cell lymphoma. ...More
phase II trial is studying how well GDC-0449 works in treating younger patients
with recurrent or refractory medulloblastoma. GDC-0449 may slow the growth of
This research study is studying biomarkers in blood samples from young patients with newly diagnosed brain tumors undergoing standard radiation therapy and chemotherapy...More
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