Clinical Study to Test Safety of a Virus Therapy in Children and Young Adults with Recurrent or Refractory Solid Tumors (Excluding Brain Tumors)
Family Friendly Version- Conditions:
Adult Studies,
Cancer - Kidney Tumors,
Cancer - Leukemia and Lymphoma,
Cancer - Liver Tumors,
Cancer - Musculoskeletal Tumors,
Cancer - Neuroblastoma,
Cancer - Neurofibromatosis Tumors,
Cancer - Retinoblastoma,
Vaccines
- Gender:
Female,
Male
Cincinnati Children’s Hospital Medical Center is conducting a research study, sometimes known as a clinical trial or clinical study, to test how safe and well tolerated the study drug is in children and young adults with certain cancers. Researchers want to see what effects - good or bad - the stud...
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ADVL0413: A Phase I/II Study of the Raf Kinase and Receptor Tyrosine Kinase Inhibitor Sorafenib (BAY 43-9006, NSC# 724772, IND# 69896) in Children With Refractory Solid Tumors or Refractory Leukemias- Conditions:
Cancer - Kidney Tumors,
Cancer - Leukemia and Lymphoma,
Cancer - Liver Tumors,
Medications
- Gender:
Female,
Male
This phase I trial is studying the side effects and best dose of sorafenib in treating young patients with relapsed or refractory solid tumors or leukemia. ...
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ADVL0911: A Phase 1 Dose Escalation Study of Seneca Valley Virus (NTX-010), A Replication-Competent Picornavirus, in Relapsed/Refractory Pediatric Patients With Neuroblastoma, Rhabdomyosarcoma, or Rare Tumors With Neuroendocrine Features- Conditions:
Cancer - Kidney Tumors,
Medications
- Gender:
Female,
Male
This phase I trial is studying the side effects and best dose of Seneca Valley virus-001 in treating young patients with relapsed or refractory neuroblastoma, rhabdomyosarcoma, or rare tumors with neuroendocrine features. ...
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ADVL0921: A Phase II Study of MLN8237 (IND# 102984), a Selective Aurora A Kinase Inhibitor in Children With Recurrent / Refractory Solid Tumors and Leukemia- Conditions:
Cancer - Kidney Tumors,
Cancer - Leukemia and Lymphoma,
Cancer - Liver Tumors,
Medications
- Gender:
Female,
Male
This phase II trial is studying the side effects of and how well Alisertib works in treating young patients with relapsed or refractory solid tumors or leukemia. ...
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HSV1716: A Phase I Dose Escalation Study of Intratumoral Herpes Simplex Virus-1 Mutant HSV1716 In Patients with Refractory Non-Central Nervous System (Non-CNS) Solid Tumors/ Therapy for Relapse- Conditions:
Cancer - Kidney Tumors,
Cancer - Liver Tumors,
Vaccines
- Gender:
Female,
Male
Primary To determine whether intratumoral injection of HSV1716, at dose levels shown to be safe for adult tumors, is safe in adolescents and young adults with non-CNS solid tumors. Time Frame: Dose limiting toxicities will be assessed at 28 days after injection of HSV1716. Secondary To measure anti...
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Study to Test Safety of a Virus Therapy Children / Young Adults- Conditions:
Adult Studies,
Cancer - Hemangioma and Vascular Malformation,
Cancer - Kidney Tumors,
Cancer - Leukemia and Lymphoma,
Cancer - Liver Tumors,
Cancer - Musculoskeletal Tumors,
Cancer - Neurofibromatosis Tumors,
Medications,
Vaccines
- Gender:
Female,
Male
Cincinnati Children’s Hospital Medical Center is conducting a research study, sometimes known as a clinical trial or clinical study, to test how safe and well tolerated the study drug is in children and young adults with certain cancers. Researchers want to see what effects - good or bad - the stu...
More
Phase II Study of Paclitaxel, Ifosfamide and Carboplatin - Conditions:
Cancer - Kidney Tumors
- Gender:
Female,
Male
Primary Determine the response rate in pediatric patients with recurrent or resistant malignant germ cell tumors treated with paclitaxel, ifosfamide, and carboplatin. SecondaryDetermine the toxicity of this regimen in these patients. Projected Accrual A total of 20 patients will be accrued for this...
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ADVL0912: A Phase I/II study of PF-02341066, an Oral Small Molecule Inhibitor of Anaplastic Lymphoma Kinase (ALK) and c-MET, in children with Relapsed/Refractory Solid Tumors, Primary CNS Tumors, and Anaplastic Large Cell Lymphoma- Conditions:
Cancer - Brain and Spinal Tumors,
Cancer - Kidney Tumors,
Cancer - Leukemia and Lymphoma,
Cancer - Liver Tumors,
Cancer - Musculoskeletal Tumors,
Cancer - Neuroblastoma,
Cancer - Retinoblastoma,
Medications
- Gender:
Female,
Male
This phase I/II trial is studying the side effects and best dose of crizotinib and to see how well it works in treating young patients with relapsed or refractory solid tumors or anaplastic large cell lymphoma. ...
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ADVL1121: A Phase II trial of the Raf Kinase and Receptor Tyrosine Kinase Inhibitor Sorafenib(IND# 69896) in Children and Young Adults with Relapsed/Refractory Rhabdomyosarcomas, Wilms Tumors, Hepatocellular Carcinoma, and Papillary Thyroid Carcinoma- Conditions:
Cancer - Kidney Tumors,
Cancer - Liver Tumors,
Cancer - Musculoskeletal Tumors
- Gender:
Female,
Male
This Phase II trial will study how well sorafenib tosylate works in treating younger patients with relapsed or refractory Rhabdomyosarcoma, Wilms Tumors, Liver cancer or Thyroid cancer ...
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