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The Peña Colorectal Center at Cincinnati Children's is home to specialists with a wide variety of backgrounds and areas of focus. This diversity allows us to be better prepared to care for your child’s unique needs. Learn more about our staff.
Andrea Bischoff, MD Pediatric Surgeon, Peña Colorectal Center 513-636-3240 firstname.lastname@example.org
Pediatric Surgeon, Peña Colorectal Center
Assistant Professor, UC Department of Surgery
Andrea Bischoff is a pediatric surgeon for the Colorectal Center at Cincinnati Children’s Hospital Medical Center. She earned her medical degree at University of Brasilia – Brasilia, Brazil. Her general surgery residency and pediatric surgical fellowship were completed at Brasilia University Hospital - Brasilia, Brazil. On October 2007 she joined the Colorectal Center at Cincinnati Children’s Hospital Medical Center for a two-year research fellowship followed by two years of clinical fellowship. In March 2012 she joined the staff as a full-time member of the Colorectal Center for Children. She has been a lecturer and visiting professor, giving courses with live operative demonstration in 20 different countries.
MD: University of Brasilia, Brasilia, Brazil.
Residency: General Surgery, Brasilia University Hospital, Brasilia, Brazil.
Pediatric Surgery Fellowship: Brasilia University Hospital, Brasilia, Brazil.
Research and International Fellowship: Cincinnati Children’s Hospital Medical Center, Cincinnati, OH.
Certification: General Surgery, Brazil, 2005; Pediatric Surgery, Brazil, 2008.
Bischoff A, Levitt MA, Breech L, Peña A. Covered Cloacal Exstrophy – A Poorly Recognized Condition, Hints to Help Arrive at a Correct Diagnosis. J Pediatr Surg. 2013;48:2389-2392.
Bischoff A, Levitt MA, Peña A. Update on the management of anorectal malformations. Pediatr Surg Int. 2013;29:899-904.
Levitt MA, Hamrick MC, Eradi B, Bischoff A, Hall J, Peña A. Transanal, Full-Thickness, Swenson-like Approach for Hirschsprung Disease. J of Pediatr Surg. 2013;48:2289-2295.
Bischoff A, Levitt MA, Breech L, Hall J, Peña A. Vaginal switch – a useful technical alternative to vaginal replacement for select cases of cloaca and urogenital sinus. J of Pediatr Surg. 2013;48:363-6.
Bischoff A, Peña A, Levitt MA. Laparoscopic-assisted PSARP – the advantages of combining both techniques for the treatment of anorectal malformations with recto-bladderneck or high prostatic fistulas. J of Pediatr Surg. 2013;48:367-71.
Bischoff A, Calvo-Garcia MA, Baregamian N, Levitt MA, Lim FY, Hall J, Peña A. Prenatal Counseling for Cloaca and Cloacal Exstrophy – Challenges faced by Pediatric Surgeons. Pediatr Surg Intl. 2012;28:781-8.
Bischoff A, Levitt MA, Peña A. Total Colonic Aganglionosis: A Surgical Challenge. How to Avoid Complications?Pediatr Surg Int. 2011;27(10):1047-52.
Peña A, Bischoff A, Levitt MA. The Transpubic Approach for Complex Anorectal and Urogenital Malformations. J Pediatr Surg. 2011;46(12):2316-2320.
Levitt MA, Bischoff A, Peña A. Pitfalls and Challenges of Cloaca Repair; How to Reduce the Need for Reoperations. J Pediatr Surg. 2011;46(6):1250-1255.
Bischoff A, Levitt MA, Breech L, Louden E, Pena A. Hydrocolpos in cloacal malformations. J Pediatr Surg. 2010,45:1241-1245.
Jason S. Frischer, MD Director, Peña Colorectal Center 513-636-3240 email@example.com
Director, Peña Colorectal Center
Director, Extracorporeal Membrane Oxygenation (ECMO) Program
Division of Pediatric General and Thoracic Surgery
Chernoguz A, Crawford, K, Vandersall A, Willson T, Denson LA, Frischer JS. Pre-treatment with Anti-VEGF therapy may exacerbate inflammation in experimental acute colitis. J Pediatr Surg. 2012 Feb;47(2):347-54.
Le LD, Keswani SG, Biesiada J, Lim FY, Kingma PS, Haberman BE, Frischer J, Habli M, Crombleholme TM. The congenital diaphragmatic hernia composite prognostic index correlates with survival in left-sided congenital diaphragmatic hernia. J Pediatr Surg. 2012 Jan;47(1):57-62.
Lawal TA, Falcone RA, von Allmen D, Denson LA, Levitt MA, Warner BW, Frischer JS. The utility of routine pouchogram before ileostomy reversal in children and adolescents following ileal pouch anal anastomosis. J Pediatr Surg. 2011 Jun;46(6):1222-5.
Chernoguz A, Crawford KM, Donovan EC, Vandersall AE, Berglund C, Cripe TP, Frischer JS. EGFR Inhibition Fails to Suppress Vascular Proliferation and Tumor Growth in a Ewing’s Sarcoma Model. J Surg Res. 2012 Mar;173(1):1-9.
Lawal TA, Frischer JS, Falcone RA, Chatoorgoon K, Denson LA, Levitt MA. The transanal approach with laparoscopy or laparotomy for the treatment of rectal strictures in Crohn’s disease. J Laparoendosc Adv Surg Tech A. 2010 Nov;20(9):791-5.
Bischoff A, Gupta A, D’Mello S, Mezoff A, Podberesky D, Barnett S, Keswani S, Frischer JS. Crohn’s disease limited to the appendix: a case report in a pediatric patient. Pediatr Surg Int. 2010 Nov;26(11):1125-8.
Vuletin JF, Lim FY, Cnota J, Kline-Fath B, Salisbury S, Haberman B, Kingma P, Frischer JS, Crombleholme T. Prenatal pulmonary hypertension index: novel prenatal predictor of severe postnatal pulmonary artery hypertension in antenatally diagnosed congenital diaphragmatic hernia. J Pediatr Surg. 2010 Apr;45(4):703-8.
Frischer JS, Lee A, Serur A, Huang J, Bae JO, Kornfield ZN, Eljuga L, Shawber CJ, Feirt N, Mansukhani M, Stempak D, Baruchel S, Bender JG, Kandel JJ, Yamashiro DJ. Inhibition of cyclooxygenase-2 disrupts tumor vascular mural cell recruitment and survival signaling. Cancer Res. 2006 Apr;66(8):4378-84.
Frischer JS, Huang J, Serur A, Kadenhe-Chiweshe A, McCrudden KW, O’Toole K, Holash J, Yancopoulos GD, Yamashiro DJ, Kandel JJ. Effects of potent VEGF blockade on experimental Wilms tumor and its persisting vasculature. Int J Onc. 2004 Sep;25(3):549-53.
Huang J, Frischer JS, Serur A, Kadenhe A, Yokoi A, McCrudden KW, New T, O’Toole K, Zabski S, Rudge JS, Holash J, Yancopoulos GD, Yamashiro DJ, Kandel JJ. Regression of established tumors and metastases by potent vascular endothelial growth factor blockade. Proc Natl Acad Sci USA. 2003 June 24;100(13):7785-90.
Michael A. Helmrath, MD, MS Surgical Director, Intestinal Rehabilitation Program 513-636-3240 firstname.lastname@example.org
Surgical Director, Intestinal Rehabilitation Program
Director of Surgical Research
Professor, UC Department of Surgery
As a pediatric surgeon, Dr. Helmrath has dedicated his career to the care of patients with intestinal failure. The main focus of his laboratory is directed towards characterizing intestinal stem cells during intestinal adaptation and developing intestinal regenerative strategies. By combining his clinical experience as the surgical director of intestinal research and rehabilitation at Cincinnati Children’s, his long-term goal is to establish translational therapies for the management of patients with short bowel syndrome.
BA: Miami University, Oxford, OH, 1987.
MD: University of Cincinnati College of Medicine, Cincinnati, OH, 1993.MS: University of Cincinnati College of Medicine, Cincinnati, OH, 1989.
Certification: Board-certified General Surgery; board-certified, Pediatric Surgery.
Michalsky MP, Inge TH, Teich S, Eneli I, Miller R, Brandt ML, Helmrath M, Harmon CM, Zeller MH, Jenkins TM, Courcoulas A, Buncher RC; Teen-LABS Consortium. Adolescent bariatric surgery program characteristics: The Teen Longitudinal Assessment of Bariatric Surgery (Teen-LABS) study experience. Semin Pediatr Surg. 2014 Feb;23(1):5-10.
Inge TH, Zeller MH, Jenkins TM, Helmrath M, Brandt ML, Michalsky MP, Harmon CM, Courcoulas A, Horlick M, Xanthakos SA, Dolan L, Mitsnefes M, Barnett SJ, Buncher R; Teen-LABS Consortium. Perioperative outcomes of adolescents undergoing bariatric surgery: the Teen-Longitudinal Assessment of Bariatric Surgery (Teen-LABS) study. JAMA Pediatr. 2014 Jan;168(1):47-53.
Ubesie AC, Kocoshis SA, Mezoff AG, Henderson CJ, Helmrath MA, Cole CR. Multiple micronutrient deficiencies among patients with intestinal failure during and after transition to enteral nutrition. J Pediatr. 2013 Dec;163(6):1692-6.
Eradi B, Hamrick M, Bischoff A, Frischer JS, Helmrath M, Hall J, Pena A, Levitt MA. The role of a colon resection in combination with a Malone appendicostomy as part of a bowel management program for the treatment of fecal incontinence. J Pediatr Surg. 2013 Nov; 48(11):2296-300.
Fuller MK, Faulk DM, Sundaram N, Mahe MM, Stout KM, von Furstenberg RJ, Smith BJ, McNaughton KK, Shroyer NF, Helmrath MA, Henning SJ. Intestinal stem cells remain viable after prolonged tissue storage. Cell Tissue Res. 2013 Nov;354(2):441-50.
Devine AA, Gonzalez A, Speck KE, Knight R, Helmrath M, Lund PK, Azcarate-Peril MA. Impact of ileocecal resection and concomitant antibiotics on the microbiome of the murine jejunum and colon. PLoS One. 2013; 8(8):e73140.
Fuller MK, Faulk DM, Sundaram N, Shroyer NF, Henning SJ, Helmrath MA. Intestinal crypts reproducibly expand in culture. J Surg Res. 2012 Nov;178(1):48-54.
Stelzner M, Helmrath M, Dunn JC, Henning SJ, Houchen CW, Kuo C, Lynch J, Li L, Magness ST, Martin MG, Wong MH, Yu J; NIH Intestinal Stem Cell Consortium. A nomenclature for intestinal in vitro cultures. Am J Physiol Gastrointest Liver Physiol. 2012 Jun 15;302(12):G1359-63.
Van Landeghem L, Blue RE, Dehmer JJ, Henning SJ, Helmrath MA, Lund PK. Localized intestinal radiation and liquid diet enhance survival and permit evaluation of long-term intestinal responses to high dose radiation in mice. PLoS One. 2012;7(12):e51310.
Adolescent Bariatrics: Assessing Health Benefits & Risk. Co-investigator. National Institute of Diabetes and Digestive and Kidney Diseases. Nov 2011 – Oct 2016. U01 DK072493.
Human Endocrine Cell Development. Co-investigator. National Institute of Diabetes and Digestive and Kidney Diseases. Apr 2012 – Mar 2017. R01 DK092456.
Belinda Hsi Dickie, MD, PhD Pediatric Surgeon, Peña Colorectal Center 513-636 3240 email@example.com
Surgical Director, Hemangioma and Vascular Malformation Program
Assistant Professor, UC Department of Pediatrics
Phone: 513-636 3240
Colorectal surgery; vascular malformations; minimally invasive surgery; general pediatric surgery
Belinda Hsi Dickie, MD, PhD, is the surgical director of the Hemangioma and Vascular Malformations Center since July 2013. She is also the director of the Vascular Anomalies Fellowship. Dr. Dickie is an assistant professor with the Division of Pediatric General and Thoracic Surgery at Cincinnati Children's Hospital Medical Center. She obtained her medical degree at the University of Toronto, and completed general surgery residency and an advanced minimally invasive surgery fellowship at the University of Alberta. She continued her training, completing fellowships in pediatric vascular malformations and pediatric colorectal surgery at Cincinnati Children’s Hospital Medical Center and in pediatric surgery at the University of Florida. She returned to Cincinnati Children’s in 2011.
Dr. Dickie has a special interest in the medical and surgical treatment of vascular malformations, and minimally invasive surgery. She has a lab in vascular biology which looks at the genetics and molecular pathways involved with lymphangiogenesis, and the genetics involved in the development of vascular malformations. The lab is looking at novel mutations in vascular malformations and the potential effects on lymphatic growth, and different treatment alternatives.
MD: University of Toronto, Toronto,Ontario, Canada 1998.Residency: General Surgery, University of Alberta, Edmonton, Alberta, Canada.Fellowship: Advanced Minimally Invasive Surgery, University of Alberta, Edmonton, Alberta, Canada; Vascular anomalies, Cincinnati Children's, Cincinnati, OH; Pediatric Colorectal Surgery, Cincinnati Children's, Cincinnati, OH; Pediatric Surgery, University of Florida Gainesville, Florida.Certification: General Surgery, 2006; Pediatric Surgery, 2011.
Dickie BH, Webb KM, Eradi B, Levitt MA. The problematic Soave cuff in Hirschsprung disease: Manifestations and treatment. J Pediatr Surg. 2014 Jan;49(1):77-81.
Knod JL, Garrison AP, Frischer JS, Dickie B. Foregut duplication cyst associated with esophageal atresia and tracheoesophageal fistula: a case report and literature review. J Pediatr Surg. 2013 May;48(5):E5-7.
de Blaauw I, Midrio P, Breech L, Bischoff A, Dickie B, Versteegh HP, Peña A, Levitt MA. Treatment of adults with unrecognized or inadequately repaired anorectal malformations: 17 cases of rectovestibular and rectoperineal fistulas. J Pediatr Adolesc Gynecol. 2013 Jun;26(3):156-60.
Levitt MA, Dickie B, Peña A. The Hirschsprungs patient who is soiling after what was considered a "successful" pull-through. Semin Pediatr Surg. 2012 Nov;21(4):344-53.
Murrell Z, Dickie B, Dasgupta R. Lung nodules in pediatric oncology patients: a prediction rule for when to biopsy. J Pediatr Surg. 2011 May;46(5):833-7.
Cuenca AG, Reddy SV, Dickie B, Kays DW, Islam S. The usefulness of the upper gastrointestinal series in the pediatric patient before anti-reflux procedure or gastrostomy tube placement. J Surg Res. 2011 Oct;170(2):247-52.
Levitt MA, Dickie B, Peña A. Evaluation and treatment of the patient with Hirschsprung disease who is not doing well after a pull-through procedure. Semin Pediatr Surg. 2010 May;19(2):146-53.
Dickie B, Dasgupta R, Nair R, Alonso MH, Ryckman FC, Tiao GM, Adams DM, Azizkhan RG. Spectrum of hepatic hemangiomas: management and outcome. J Pediatr Surg. 2009 Jan;44(1):125-33.
Kneteman NM, Weiner AJ, O'Connell J, Collett M, Gao T, Aukerman L, Kovelsky R, Ni ZJ, Zhu Q, Hashash A, Kline J, Hsi B, Schiller D, Douglas D, Tyrrell DL, Mercer DF. Anti-HCV therapies in chimeric scid-Alb/uPA mice parallel outcomes in human clinical application. Hepatology. 2006 Jun;43(6):1346-53. Hao C, Song JH, Hsi B, Lewis J, Song DK, Petruk KC, Tyrrell DL, Kneteman NM. TRAIL inhibits tumor growth but is nontoxic to human hepatocytes in chimeric mice. Cancer Res. 2004 Dec 1;64(23):8502-6.
Alberto Peña, MD Founding Director, Peña Colorectal Center 513-636-3240 firstname.lastname@example.org
Founding Director, Peña Colorectal Center
Colorectal pediatric surgery; clinical research regarding colorectal problems in children
Alberto Peña, MD, is the founding director of the Colorectal Center at Cincinnati Children's and clinical professor of surgery at the University of Cincinnati. He received his medical degree at the Military Medical School in Mexico City in 1962.
Dr. Peña trained in general surgery and medical pediatrics at the Central Military Hospital, finishing in 1968. From 1969 until December 1971, he trained at Boston Children's Hospital.
Dr. Peña moved back to Mexico City as the surgeon-in-chief of the National Institute of Pediatrics from January 1972 until June 1985.
In 1982, Dr. Peña described a new approach for the management of anorectal malformations: Posterior Sagittal Anoplasty / PSARP, also known as the Peña Pull-Through Procedure.
Dr. Peña joined the full-time staff at Schneider Children's Hospital in July 1985 and was the chief of Pediatric Surgery and professor of Surgery at the Albert Einstein College of Surgeons until July 2005.
Since 1982 until the present, Dr. Peña has been traveling all over the world, lecturing and operating on children affected by this particular malformation.
In July 2005 Dr. Peña moved to Cincinnati Children's and became the director of the first colorectal center for children in the world.
At the present time, Dr. Peña dedicates 80 percent of his time to the treatment of anorectal problems in children.
Seventy percent of the patients operated on by Dr. Peña at Cincinnati Children's come from other states and from all over the world.
Dr. Peña has published over 179 papers in national and international journals and has published 80 book chapters.
Bischoff A, Levitt MA, Breech L, Peña A. Covered cloacal exstrophy--a poorly recognized condition: hints for a correct diagnosis. J Pediatr Surg. 2013 Dec;48(12):2389-92.
Eradi B, Hamrick M, Bischoff A, Frischer JS, Helmrath M, Hall J, Peña A, Levitt MA. The role of a colon resection in combination with a Malone appendicostomy as part of a bowel management program for the treatment of fecal incontinence. J Pediatr Surg. 2013 Nov;48(11):2296-300.
Levitt MA, Hamrick MC, Eradi B, Bischoff A, Hall J, Peña A. Transanal, full-thickness, Swenson-like approach for Hirschsprung disease. J Pediatr Surg. 2013 Nov;48(11):2289-95.
Bischoff A, Levitt MA, Peña A. Update on the management of anorectal malformations. Pediatr Surg Int. 2013 Sep;29(9):899-904.
Brisighelli G, Bischoff A, Levitt M, Hall J, Monti E, Peña A. Coloboma and anorectal malformations: a rare association with important clinical implications. Pediatr Surg Int. 2013 Sep;29(9):905-12.
Bischoff A, Peña A, Levitt MA. Laparoscopic-assisted PSARP - the advantages of combining both techniques for the treatment of anorectal malformations with recto-bladderneck or high prostatic fistulas. J Pediatr Surg. 2013 Feb;48(2):367-71.
Bischoff A, Levitt MA, Breech L, Hall J, Peña A. Vaginal switch--a useful technical alternative to vaginal replacement for select cases of cloaca and urogenital sinus. J Pediatr Surg. 2013 Feb;48(2):363-6. Erratum in: J Pediatr Surg. 2013 Sep;48(9):1993.
Bischoff A, Calvo-Garcia MA, Baregamian N, Levitt MA, Lim FY, Hall J, Peña A. Prenatal counseling for cloaca and cloacal exstrophy-challenges faced by pediatric surgeons. Pediatr Surg Int. 2012 Aug;28(8):781-8.
Hamrick M, Eradi B, Bischoff A, Louden E, Peña A, Levitt M. Rectal atresia and stenosis: unique anorectal malformations. J Pediatr Surg. 2012 Jun;47(6):1280-4.
Daniel von Allmen, MD Director, Division of General and Thoracic Surgery 513-636-4371 email@example.com
Director, Division of General and Thoracic Surgery
Pediatric surgical oncology; pediatric inflammatory bowel disease; surgical innovation; surgical robotics
Oncology; innovation; surgical workforce
Daniel von Allmen, MD, comes to Cincinnati from Chapel Hill, NC where he was the surgeon-in-chief and division chief at the North Carolina Children’s Hospital.
Dr. von Allmen completed his general surgery training at the University of Cincinnati and Cincinnati Children’s Hospital Medical Center. He is currently the Program Committee chair of the American Pediatric Surgical Association. He also serves on the Program Committee for the American Academy of Pediatrics Surgical Section and is a member of the Steering Committee for the Surgical Section of the Children’s Oncology Group.
Dr. von Allmen's special clinical interests include pediatric surgical oncology, pediatric inflammatory bowel disease, surgical innovation, and surgical robotics.
Mayer ML, Beil HA, von Allmen D. Distance to care and relative supply among pediatric surgical subspecialties. J Pediatr Surg. 2009;44:483-495.
Kimberly E. Cain, MSN, APRN, CFNP, CWOCN Nurse Practitioner, Pediatric Advanced Wound Center 513-803-1161 firstname.lastname@example.org
Nurse Practitioner, Pediatric Advanced Wound Center
Wound, ostomy and incontinence care
Ebony Moorefield, MSN, APRN, PNP Pediatric Nurse Practitioner, Peña Colorectal Center 513-636-3240 email@example.com
Pediatric Nurse Practitioner, Peña Colorectal Center
BSN: Carlow University, Pittsburgh, PA.
MSN: University of Pittsburgh, Pittsburgh, PA.
Certification: Pediatric Nursing Certification Board.
Courtney N. Tyra, MS, CCLS
Child Life Specialist, Division of Child Life 513-636-8998 firstname.lastname@example.org
Conrad R. Cole, MD, MPH, MSc Director, Intestinal Rehabilitation 513-636-4415 email@example.com
Director, Intestinal Rehabilitation
Associate Professor, UC Department of Pediatrics
Intestinal failure; short bowel syndrome; growth failure; failure to thrive malabsorption disorders; micronutrient malnutrition
Conrad Cole, MD, is an expert in the management of infants with intestinal failure and short bowel syndrome. He is an associate director of the Pediatric Nutrition and Intestinal Care Center in the Division of Gastroenterology, Hepatology and Nutrition. In addition, he is an associate professor of pediatrics at the University of Cincinnati College of Medicine.
Dr. Cole's research interest is in the epidemiology of intestinal failure and it's complications especially in identifying risk factors associated with worsening prognosis. He is also interested in micronutrient malnutrition specifically zinc and iron and how they impact other micronutrients in preschool children especially from low income minority populations.
Prior to joining Cincinnati Children's, Dr. Cole was at Emory University's Schools of Medicine and Public Health. Dr. Cole earned his medical degree from the University of Ibadan, and also completed graduate degrees in public health from Ohio State University and clinical research from Emory University. He received training in nutrition under the mentorship of Fima Lifshitz MD at Maimonides Medical Center and Miami Children's Hospital prior to completing an internship and residency in pediatrics at the Miami Children's Hospital; and a fellowship in pediatric gastroenterology at Cincinnati Children's Hospital Medical Center.
Cole CR, Grant FK, Swaby-Ellis ED, Smith JL, Jacques A, Northrop-Clewes CA, Caldwell KL, Pfeiffer CM, Ziegler TR. Zinc and iron deficiency and their interrelationship in low-income African American and Hispanic children in Atlanta. American Journal of Clinical Nutrition. 2010;91:1027-1034.
Cole CR, Grant FK, Tangpricha V, Swaby-Ellis ED, Smith JL, Jacques A, Chen HP, Schleicher RL, Ziegler TR. 25-hydroxyvitamin D status of healthy low-income minority children in Atlanta. Pediatrics. 2010;125: 633-639.
Cole C, Freitas A, Clifton MS, Durham MM. Hereditary Multiple Intestinal Atresias: two new cases and review of the literature. Journal of Pediatric Surgery. 2010;45:E21-24.
Frem J, Sarson Y. Sternberg T, Cole CR. Copper supplementation in parenteral nutrition of cholestatic infants. Journal of Pediatric Gastroenterology, Hepatology and Nutrition. 2010;50: 650-654.
Cole CR, Frem JC, Schmotzer B, Gewirtz AT, Meddings JB, Gold BD, Ziegler TR. The rate of bloodstream infection is high in infants with short bowel syndrome: Relationship with small bowel bacterial overgrowth, enteral feeding and inflammatory and immune responses. Journal of Pediatrics. 2010;156: 941-947.e1.
Frem, J, Gold B, Shehada B, Cole C. Reflux masquerader: Acute H. pylori infection in infants. Journal of Pediatric Gastroenterology & Nutrition. 2008;46:589-592.
Cole CR, Hansen N, Huggins R, Ziegler TR, Stoll BJ for the NICHD neonatal research network. Very low birth weight preterm infants with surgical short bowel syndrome: incidence, morbidity and mortality and growth outcomes at 18-22 months. Pediatrics. 2008;112:e573-582.
Lee A. Denson, MD Medical Director, Inflammatory Bowel Disease Center 513-636-7575 firstname.lastname@example.org
Medical Director, Inflammatory Bowel Disease Center
Professor, UC Department of Pediatrics
Inflammatory bowel disease; growth failure; celiac disease
Visit the Denson Lab.
The primary focus of Dr. Lee A. Denson's laboratory is to determine the molecular basis for alterations in growth hormone signaling in inflammatory bowel diseases (IBD).
Normal growth and development are dependent upon the ability of growth hormone to regulate IGF-1 expression. Evidence from studies in children with IBD and mouse models of colitis indicates that inflammatory cytokines which are up regulated in this setting may cause an acquired GH resistance. Consequences may include growth failure, altered body composition and impaired mucosal healing.
We are using complementary experimental and patient-based approaches to investigate regulation of growth hormone signaling in mouse models of colitis and in children with Crohn's disease. These include down regulation of the growth hormone receptor and up regulation of a family of post-receptor inhibitory proteins, the Suppressors of Cytokine Signaling (SOCS). These studies should lead to the development of more effective therapies for children with IBD and other chronic inflammatory conditions.
Herzer M, Denson LA, Baldassano RN, Hommel KA. Family functioning and health-related quality of life in adolescents with pediatric inflammatory bowel disease. Eur J Gastroenterol Hepatol. 2011 Jan;23(1):95-100.
Gray WN, Denson LA, Baldassano RN, Hommel KA. Disease activity, behavioral dysfunction, and health-related quality of life in adolescents with inflammatory bowel disease. Inflamm Bowel Dis. 2010 Nov 4.
Lawal TA, Frischer JS, Falcone RA, Chatoorgoon K, Denson LA, Levitt MA. The transanal approach with laparoscopy or laparotomy for the treatment of rectal strictures in Crohn's disease. J Laparoendosc Adv Surg Tech A. 2010 Nov;20(9):791-5.
Denson LA, Kim MO, Bezold R, Carey R, Osuntokun B, Nylund C, Willson T, Bonkowski E, Li D, Ballard E, Collins M, Moyer MS, Klein DJ. A randomized controlled trial of growth hormone in active pediatric Crohn disease. J Pediatr Gastroenterol Nutr. 2010 Aug;51(2):130-9.
Nylund CM, Denson LA, Noel JM. Bacterial enteritis as a risk factor for childhood intussusception: a retrospective cohort study. J Pediatr. 2010 May;156(5):761-5.
Ingerski LM, Baldassano RN, Denson LA, Hommel KA. Barriers to oral medication adherence for adolescents with inflammatory bowel disease. J Pediatr Psychol. 2010 Jul;35(6):683-91.
Tomer G, Wetzler G, Keddache M, Denson LA. Polymorphisms in the IBD5 locus are associated with Crohn disease in pediatric Ashkenazi Jewish patients. J Pediatr Gastroenterol Nutr. 2009 May;48(5):531-7.
Uchida K, Nakata K, Suzuki T, Luisetti M, Watanabe M, Koch DE, Stevens CA, Beck DC, Denson LA, Carey BC, Keicho N, Krischer JP, Yamada Y, Trapnell BC. Granulocyte/macrophage-colony-stimulating factor autoantibodies and myeloid cell immune functions in healthy subjects. Blood. 2009 Mar 12;113(11):2547-56.
Han X, Uchida K, Jurickova I, Koch D, Willson T, Samson C, Bonkowski E, Trauernicht A, Kim MO, Tomer G, Dubinsky M, Plevy S, Kugathsan S, Trapnell BC, Denson LA. Granulocyte-macrophage colony-stimulating factor autoantibodies in murine ileitis and progressive ileal Crohn's disease. Gastroenterology. 2009 Apr;136(4):1261-71, e1-3.
Denson LA. Growth hormone therapy in children and adolescents: pharmacokinetic/pharmacodynamic considerations and emerging indications. Expert Opin Drug Metab Toxicol. 2008 Dec;4(12):1569-80. Review.
Ajay Kaul, MD Director, Neurogastroenterology and Motility Disorders 513-636-4415 email@example.com
Director, Neurogastroenterology and Motility Disorders
Director, Gastrointestinal Operations, Liberty Campus
Motility disorders; feeding disorders; GI problems in children with special needs
Kaul A, Garza JM, Connor FL, Cocjin JT, Flores AF, Hyman PE, Di Lorenzo C. Colonic Hyperactivity Results in Frequent Fecal Soiling in a Subset of Children After Surgery for Hirschsprung Disease. J Pediatr Gastroenterol Nutr. 2011 Jan 12.
Blanchard C, Stucke EM, Rodriguez-Jimenez B, Burwinkel K, Collins MH, Ahrens A, Alexander ES, Butz BK, Jameson SC, Kaul A, Franciosi JP, Kushner JP, Putnam PE, Abonia JP, Rothenberg ME. A striking local esophageal cytokine expression profile in eosinophilic esophagitis. J Allergy Clin Immunol. 2011 Jan;127(1):208-17, 217.e1-7.
Garza JM, Kaul A. Gastroesophageal reflux, eosinophilic esophagitis, and foreign body. Pediatr Clin North Am. 2010 Dec;57(6):1331-45. Review.
Zhu X, Wang M, Mavi P, Rayapudi M, Pandey AK, Kaul A, Putnam PE, Rothenberg ME, Mishra A. Interleukin-15 expression is increased in human eosinophilic esophagitis and mediates pathogenesis in mice. Gastroenterology. 2010 Jul;139(1):182-93.e7.
Caldwell JM, Blanchard C, Collins MH, Putnam PE, Kaul A, Aceves SS, Bouska CA, Rothenberg ME. Glucocorticoid-regulated genes in eosinophilic esophagitis: a role for FKBP51. J Allergy Clin Immunol. 2010 Apr;125(4):879-888.e8.
Blanchard C, Stucke EM, Burwinkel K, Caldwell JM, Collins MH, Ahrens A, Buckmeier BK, Jameson SC, Greenberg A, Kaul A, Franciosi JP, Kushner JP, Martin LJ, Putnam PE, Abonia JP, Wells SI, Rothenberg ME. Coordinate interaction between IL-13 and epithelial differentiation cluster genes in eosinophilic esophagitis. J Immunol. 2010 Apr 1;184(7):4033-41.
Jafri M, Alonso M, Kaul A, Dierig J, Racadio J, Inge T, Brown R, Ryckman F, Tiao G. Intraoperative manometry during laparoscopic Heller myotomy improves outcome in pediatric achalasia. J Pediatr Surg. 2008 Jan;43(1):66-70; discussion 70.
Pentiuk SP, Miller CK, Kaul A. Eosinophilic esophagitis in infants and toddlers. Dysphagia. 2007 Jan;22(1):44-8.
Boesch RP, Daines C, Willging JP, Kaul A, Cohen AP, Wood RE, Amin RS. Advances in the diagnosis and management of chronic pulmonary aspiration in children. Eur Respir J. 2006 Oct;28(4):847-61. Review.
Bates MD, Dunagan DT, Welch LC, Kaul A, Harvey RP. The Hlx homeobox transcription factor is required early in enteric nervous system development. BMC Dev Biol. 2006 Jul 19;6:33.
Shehzad Ahmed Saeed, MD, FAAP, AGAF Clinical Director, Schubert–Martin Inflammatory Bowel Disease Center 513-803-3251 firstname.lastname@example.org
Clinical Director, Schubert–Martin Inflammatory Bowel Disease Center
Clinical Director, Division of Gastroenterology, Hepatology and Nutrition
Medical Director, Gi/Colorectal Inpatient Unit
Inflammatory bowel disease
Hocking MC, Barnes M, Shaw C, Lochman JE, Madan-Swain A, Saeed S. Executive function and attention regulation as predictors of coping success in youth with functional abdominal pain. J Pediatr Psychol. 2011 Jan;36(1):64-73.
Schaefer ME, Machan JT, Kawatu D, Langton CR, Markowitz J, Crandall W, Mack DR, Evans JS, Pfefferkorn MD, Griffiths AM, Otley AR, Bousvaros A, Kugathasan S, Rosh JR, Keljo DJ, Carvalho RS, Tomer G, Mamula P, Kay MH, Kerzner B, Oliva-Hemker M, Kappelman MD, Saeed SA, Hyams JS, Leleiko NS. Factors that determine risk for surgery in pediatric patients with Crohn's disease. Clin Gastroenterol Hepatol. 2010 Sep;8(9):789-94.
Malik TA, Saeed S. Autoimmune hepatitis: a review. J Pak Med Assoc. 2010 May;60(5):381-7. Wallander JL, Madan-Swain A, Klapow J, Saeed S. A randomised controlled trial of written self-disclosure for functional recurrent abdominal pain in youth. Psychol Health. 2010 Apr 21:1-15.
Imielinski M, Baldassano RN, Griffiths A, et.al. Common variants at five new loci associated with early-onset inflammatory bowel disease. Nat Genet. 2009 Dec;41(12):1335-40.
Colletti RB, Baldassano RN, Milov DE, Margolis PA, Bousvaros A, Crandall WV, Crissinger KD, D'Amico MA, Day AS, Denson LA, Dubinsky M, Ebach DR, Hoffenberg EJ, Kader HA, Keljo DJ, Leibowitz IH, Mamula P, Pfefferkorn MD, Qureshi MA; Pediatric IBD Network for Research and Improvement. Variation in care in pediatric Crohn disease. J Pediatr Gastroenterol Nutr. 2009 Sep;49(3):297-303. Maheshwari A, Kurundkar AR, Shaik SS, Kelly DR, Hartman Y, Zhang W, Dimmitt R, Saeed S, Randolph DA, Aprahamian C, Datta G, Ohls RK. Epithelial cells in fetal intestine produce chemerin to recruit macrophages. Am J Physiol Gastrointest Liver Physiol. 2009 Jul;297(1):G1-G10. Donnithorne KJ, Atkinson TP, Hinze CH, Nogueira JB, Saeed SA, Askenazi DJ, Beukelman T, Cron RQ. Rituximab therapy for severe refractory chronic Henoch-Schönlein purpura. J Pediatr. 2009 Jul;155(1):136-9. Haricharan RN, Proklova LV, Aprahamian CJ, Morgan TL, Harmon CM, Barnhart DC, Saeed SA. Laparoscopic cholecystectomy for biliary dyskinesia in children provides durable symptom relief. J Pediatr Surg. 2008 Jun;43(6):1060-4. Britton LJ, Saeed SA. Abdominal pain in cystic fibrosis. J Pediatr Health Care. 2008 Nov-Dec;22(6):383-6.
Jens W. Goebel, MD Clinical Director, Nephrology and Hypertension 513-636-4531 email@example.com
Clinical Director, Nephrology and Hypertension
Medical Director, Kidney Transplantation
Clinical Director, Kidney Transplantation
Organ transplantation in children
Sanchez-Pinto LN, Laskin BL, Jodele S, Hummel TR, Yin HJ, Goebel J. BK virus nephropathy in a pediatric autologous stem-cell transplant recipient. Pediatr Blood Cancer. 2011 Mar;56(3):495-7. Hooper DK, Carle AC, Schuchter J, Goebel J. Interaction between tacrolimus and intravenous nicardipine in the treatment of post-kidney transplant hypertension at pediatric hospitals. Pediatr Transplant. 2011 Feb;15(1):88-95. Sherwin CM, Fukuda T, Brunner HI, Goebel J, Vinks AA. The evolution of population pharmacokinetic models to describe the enterohepatic recycling of mycophenolic acid in solid organ transplantation and autoimmune disease. Clin Pharmacokinet. 2011 Jan 1;50(1):1-24.Campbell K, Ng V, Martin S, Magee J, Goebel J, Anand R, Martz K, Bucuvalas J; SPLIT Renal Function Working Group. Glomerular filtration rate following pediatric liver transplantation--the SPLIT experience. Am J Transplant. 2010 Dec;10(12):2673-82. Pai AL, Gray E, Kurivial K, Ross J, Schoborg D, Goebel J. The Allocation of Treatment Responsibility scale: a novel tool for assessing patient and caregiver management of pediatric medical treatment regimens. Pediatr Transplant. 2010 Dec;14(8):993-9.Jodele S, Bleesing JJ, Mehta PA, Filipovich AH, Laskin BL, Goebel J, Pinkard SL, Davies SM. Successful early intervention for hyperacute transplant-associated thrombotic microangiopathy following pediatric hematopoietic stem cell transplantation. Pediatr Transplant. 2010 Nov 5. Pai AL, Ingerski LM, Perazzo L, Ramey C, Bonner M, Goebel J. Preparing for transition? The allocation of oral medication regimen tasks in adolescents with renal transplants. Pediatr Transplant. 2011 Feb;15(1):9-16. Laskin BL, Goebel J, Davies SM, Khoury JC, Bleesing JJ, Mehta PA, Filipovich AH, Paff ZN, Lawrence JM, Yin HJ, Pinkard SL, Jodele S. Early clinical indicators of transplant-associated thrombotic microangiopathy in pediatric neuroblastoma patients undergoing auto-SCT. Bone Marrow Transplant. 2010 Aug 9.
Herzer M, Goebel J, Cortina S. Transitioning cognitively impaired young patients with special health needs to adult-oriented care: collaboration between medical providers and pediatric psychologists. Curr Opin Pediatr. 2010 Oct;22(5):668-72.
Fukuda T, Goebel J, Thøgersen H, Maseck D, Cox S, Logan B, Sherbotie J, Seikaly M, Vinks AA. Inosine Monophosphate Dehydrogenase (IMPDH) Activity as a Pharmacodynamic Biomarker of Mycophenolic Acid Effects in Pediatric Kidney Transplant Recipients. J Clin Pharmacol. 2010 Apr 23.
NIH UO1 grant: Noninvasive Monitoring to Predict Outcome in de novo Kidney Transplant Recipients (CTOT-01, Protocol Chair: P. Heeger, MD, City), commenced in late 2005 and ongoing
NIH UO1 grant: Health and Literacy in Child and Adult Assessment: Expanded Testing of the Pediatric PROMIS (Patient Reported Outcomes Measurement Information System) Tool (Sponsor: D. DeWalt, MD, MPH, ), ongoing.
NIH UO1 grant: Chronic Kidney Disease in Children (CKID, PI: B. Warady, MD, Children’s Mercy Hospital, Kansas City, MO), ongoing.
NIH RO1 grant: Calcineurin Inhibitor Minimization And Foxp3+ Tregs Post-Transplant (PIs: Wayne Hancock, MD, Children’s , and John Bucuvalas, MD, Cincinnati Children’s Hospital), ongoing.
Midwest Pediatric Nephrology Consortium: Assessing and Implementing Transition to Adult Care in Children with CKD (PI: M. Ferris, MD, MPH, PhD, ), ongoing
Amgen Pharmaceuticals: Pediatric Anemia Correction Study (Protocol 20050256), ongoing.
Roche Pharmaceuticals: Development of Population Pharmacokinetic models of Mycophenolic Acid for use in Bayesian Dose Individualization in Pediatric Kidney Transplant Patients (PI: A. Vinks, Cincinnati Children’s Hospital), ongoing.
Cincinnati Children’s Hospital Medical Center Outcomes Research Award: Validation of a Real-Time Adherence Assessment System (PI: A. Pai, PhD, Cincinnati Children’s Hospital), ongoing.
Cincinnati Children’s Hospital Medical Center Translational Research Initiative grant: Pharmacogenetics of Mycophenolic Acid in Kidney Transplant Patients (PI: A. Vinks, Cincinnati Children’s Hospital), ongoing.
Cincinnati Children’s Hospital Medical Center Translational Research Initiative grant: Biomarkers for Patient-tailored Therapies in Pediatric Lupus Nephritis using Mycophenolic Acid (PI: H. Brunner, Cincinnati Children’s Hospital), ongoing.
Cincinnati Children’s Hospital Medical Center Translational Research Initiative grant: Pharmacogenetics of IMPDH in Kidney Transplant Patients (PI: A. Vinks, Cincinnati Children’s Hospital), ongoing.
Francesco T. Mangano, DO, FACS, FACOS Chief, Division of Pediatric Neurosurgery 513-636-4726 firstname.lastname@example.org
Chief, Division of Pediatric Neurosurgery
Director, Pediatric Epilepsy Surgery Program
Associate Professor, UC Department of Neurosurgery
Francesco Mangano joined the Division of Pediatric Neurosurgery at Cincinnati Children's in July 2005, as an associate professor of neurosurgery.A graduate of the Philadelphia College of Osteopathic Medicine, Dr. Mangano completed his neurosurgical residency at Long Island Jewish Medical Center in 2004 followed by a fellowship in pediatric neurosurgery at St. Louis Children's Hospital in St. Louis, Missouri. Since joining the faculty of the division of pediatric neurosurgery at this Cincinnati Children's Hospital Medical Center, he has been instrumental in developing our nationally renowned Pediatric Epilepsy Program and is director of the Pediatric Epilepsy Surgery Program. This program has already given many children a chance to experience a whole new life with marked reduction in the frequency of their debilitating seizures. After extensive evaluation and state of the art imaging and monitoring of the seizures, surgical intervention in many cases can then be exactly targeted to the source of the seizures. An extensive array of surgical techniques may be offered these patients, which ranges from implantation of a vagal nerve stimulator to resection of one whole side of the brain. In addition, he is a co-principal investigator for an NIH-funded multi-institutional research study investigating advanced MRI imaging techniques in children with congenital hydrocephalus. This is only one of his numerous active research projects which have resulted in numerous publications, book chapters and national and international presentations in the fields of epilepsy, diffusion tensor imaging (MRI) of hydrocephalus, traumatic brain injury, and vascular and neoplastic brain lesions. He also has expertise in complex disorders of the spine and spinal cord, including spinal cord tumors, and craniocervical junction.
Dr. Mangano is a member of the American Society of Pediatric Neurosurgeons. He was board certified in 2008 in Neurological Surgery by the American Osteopathic Board of Surgery.
DO: Philadelphia College of Osteopathic Medicine (PCOM), Philadelphia, PA.Residency: NYCOM-Long Island, Jewish Medical Center / North Shore University Health System, New Hyde Park, NY.Fellowship: Washington University School of Medicine-St. Louis Children's Hospital, St. Louis, MO.
Board Certification: Neurological Surgery, American Osteopathic Board of Surgery, 2008.
Kadar AA, Hearst MJ, Collins MH, Mangano FT, Samy RN. Ewing's Sarcoma of the Petrous Temporal Bone: Case Report and Literature Review. Skull Base. 2010 May;20(3):213-7.
Seo JH, Holland K, Rose D, Rozhkov L, Fujiwara H, Byars A, Arthur T, DeGrauw T, Leach JL, Gelfand MJ, Miles L, Mangano FT, Horn P, Lee KH. Multimodality imaging in the surgical treatment of children with nonlesional epilepsy. Neurology. 2011 Jan 4;76(1):41-8.
Yuan W, Deren KE, McAllister JP 2nd, Holland SK, Lindquist DM, Cancelliere A, Mason M, Shereen A, Hertzler DA, Altaye M, Mangano FT. Diffusion tensor imaging correlates with cytopathology in a rat model of neonatal hydrocephalus. Cerebrospinal Fluid Res. 2010 Nov 5;7:19.
Hertzler DA 2nd, DePowell JJ, Stevenson CB, Mangano FT. Tethered cord syndrome: a review of the literature from embryology to adult presentation. Neurosurg Focus. 2010 Jul;29(1):E1. Review.
Patel NN, Mangano FT, Klimo P Jr. Indirect revascularization techniques for treating moyamoya disease. Neurosurg Clin N Am. 2010 Jul;21(3):553-63. Review.
Air EL, Yuan W, Holland SK, Jones BV, Bierbrauer K, Altaye M, Mangano FT. Longitudinal comparison of pre- and postoperative diffusion tensor imaging parameters in young children with hydrocephalus. J Neurosurg Pediatr. 2010 Apr;5(4):385-91.
Desai R, Stevenson CB, Crawford AH, Durrani AA, Mangano FT. C-1 lateral mass screw fixation in children with atlantoaxial instability: case series and technical report. J Spinal Disord Tech. 2010 Oct;23(7):474-9.
Xiang J, Wang Y, Chen Y, Liu Y, Kotecha R, Huo X, Rose DF, Fujiwara H, Hemasilpin N, Lee K, Mangano FT, Jones B, DeGrauw T. Noninvasive localization of epileptogenic zones with ictal high-frequency neuromagnetic signals. J Neurosurg Pediatr. 2010 Jan;5(1):113-22.
Yuan W, Mangano FT, Air EL, Holland SK, Jones BV, Altaye M, Bierbrauer K. Anisotropic diffusion properties in infants with hydrocephalus: a diffusion tensor imaging study. AJNR Am J Neuroradiol. 2009 Oct;30(9):1792-8.
Xiang J, Liu Y, Wang Y, Kirtman EG, Kotecha R, Chen Y, Huo X, Fujiwara H, Hemasilpin N, Lee K, Mangano FT, Leach J, Jones B, DeGrauw T, Rose D. Frequency and spatial characteristics of high-frequency neuromagnetic signals in childhood epilepsy. Epileptic Disord. 2009 Jun;11(2):113-25.
Charles B. Stevenson, MD Faculty Neurosurgeon, Division of Pediatric Neurosurgery 513-636-4726 email@example.com
Faculty Neurosurgeon, Division of Pediatric Neurosurgery
Assistant Professor, UC Department of Neurosurgery
Brain tumors; spasticity; Chiari malformations; fetal surgery; neurovascular disorders; minimal access surgery
Neuro-oncology; epilepsy; spasticity
Charles Stevenson, MD, rejoined the Division of Pediatric Neurosurgery at Cincinnati Children's Hospital Medical Center in July 2010, after having served for one year as staff neurosurgeon at Kosair Children’s Hospital in Louisville, Kentucky. Prior to completing his fellowship in pediatric neurosurgery at Cincinnati Children’s, he received his neurosurgical training at Vanderbilt University in Nashville, Tennessee. During that time, he also completed a two-year research fellowship in neurosurgical oncology. He graduated from medical school at Vanderbilt University in Nashville, Tennesee. Dr. Stevenson’s interest, specialized training and research background in neuro-oncology make him uniquely qualified to lead our division in its collaborative efforts with the division of neuro-oncology in the Brain and Spinal Tumor program to treat children with primary and recurrent brain tumors. He is assisted in these efforts by leading-edge technology such as the operating room BrainSUITE™, which creates precise three-dimensional maps of the brain and allows for intraoperative MRI imaging to more safely remove particularly complex and deep-seated tumors. Cincinnati Children’s was the first pediatric hospital in the world to offer this technology. In addition, Dr. Stevenson brings expertise in selective dorsal rhizotomy as a treatment for spasticity, which, when added to implantation of baclofen pumps and medical therapy, allows for a wide range of treatment options for patients with spasticity from cerebral palsy or spinal cord injury. He is a member of a multidisciplinary team of specialists that includes neurosurgery, orthopedic surgery, physical medicine and rehabilitation as well as and physical and occupational therapies that offers comprehensive care for children with spasticity.
Dr. Stevenson is a member of the American Society of Pediatric Neurosurgeons. He was board certified in 2013 in neurological surgery by the American Board of Neurological Surgeons.
MD: Vanderbilt University School of Medicine, Nashville, Tennessee, 2001 Residency: Neurosurgery, Vanderbilt University Medical Center, Nashville, Tennessee Fellowship: Pediatric Neurosurgery, Cincinnati Children's Hospital Medical Center, 2008-09.
Board Certification: Neurological Surgery, American Board of Neurological Surgeons, 2013.
Hertzler II DA, DePowell JJ, Stevenson CB, Mangano FT. Tethered cord syndrome: a review of the literature from embryology to adult presentation. Neurosurgical Focus. 2010;29(1):E1. Stevenson CB, Desai RR, Crawford AH, Durrani AA, Mangano FT. C-1 lateral mass screw fixation in children with atlantoaxial instability: case series and technical report. Journal of Spinal Disorders and Techniques. 2010 Oct;23(7):474-9. Reig AS, Stevenson CB, Tulipan NT. CT-based, fiducial-free frameless stereotaxy for difficult ventriculoperitoneal shunt insertion: experience in 26 consecutive patients. Stereotactic and Functional Neurosurgery. 2010; 88(2):75-80. Stevenson CB, Leach JL, Gupta A, Crone KR. Cystic degeneration of the cerebellar tonsils in pediatric patients with Chiari I malformation. J Neurosurg Ped. 2009; 4(6):557-63. McMillan KM, Ehtesham M, Stevenson CB, Edgeworth ML, Thompson RC, Price RR. T2 detection of tumor invasion within segmented components of glioblastoma multiforme. J Mag Reson Imag. 2009; 29(2):251-7. Ehtesham M, Mapara KY, Stevenson CB, Thompson RC. CXCR4 mediates the proliferation of glioblastoma progenitor cells. Cancer Letters. 2009; 274(2):305-12. Ehtesham M, Stevenson CB, Thompson RC. Preferential expression of chemokine receptor CXCR4 by highly malignant human gliomas and its association with poor patient survival. Neurosurgery. 2008; 63(4):E820. Stevenson CB, Ehtesham M, McMillan KM, Valadez JG, Edgeworth ML, Price RR, Abel TW, Mapara KY, Thompson RC. CXCR4 expression is elevated in glioblastoma multiforme and correlates with an increase in intensity and extent of peri-tumoral T2-weighted MRI signal abnormalities. Neurosurgery. 2008;63(3):560-9. Johnson MD, Stevenson CB, Thompson RC, Atkinson J, Boyer P. 31-year-old woman with hemiparesis . Brain Pathology. 2007;17(2):255-7.
Stevenson CB, Crone KR. Head injury. In Operative Pediatric Surgery Ziegler MM, Azizkhan RG, Weber T, von Allmen D (eds.). 2nd Edition. Mcgraw-Hill: New York ,NY, 2012. (In press).
Lucy Muskthel, RD, LD, CNSC
Registered Dietitian, Division of Nutrition Therapy 513-636-6082 firstname.lastname@example.org
Lesley L. Breech, MD Division Director, Division of Pediatric and Adolescent Gynecology email@example.com
Division Director, Division of Pediatric and Adolescent Gynecology
Associate Professor, UC Department of Surgery
UC Department of Obstetrics and Gynecology
Female genital anomalies; young women with bleeding disorders; reproductive outcomes after treatment for cancer
MD: Ohio State University Columbus, OH, 1994.
Residency: Ob / Gyn, Washington University, St Louis, MO, 1998.
Fellowship: Pediatric & Adolescent Gynecology, Washington University, St Louis Children's Hospital, St Louis, MO, 2000.
Certification: American Board of Obstetrics and Gynecology, 2000.
Breech LL, Braverman PK. Safety, efficacy, actions, and patient acceptability of drospirenone/ethinyl estradiol contraceptive pills in the treatment of premenstrual dysphoric disorder. Int J Womens Health. 2010 Aug 9;1:85-95. Vallerie AM, Breech LL. Update in Müllerian anomalies: diagnosis, management, and outcomes. Curr Opin Obstet Gynecol. 2010 Oct;22(5):381-7. Bischoff A, Levitt MA, Breech L, Louden E, Peña A. Hydrocolpos in cloacal malformations. J Pediatr Surg. 2010 Jun;45(6):1241-5. Peña A, Bischoff A, Breech L, Louden E, Levitt MA. Posterior cloaca − further experience and guidelines for the treatment of an unusual anorectal malformation. J Pediatr Surg. 2010 Jun;45(6):1234-40. Breech L. Gynecologic concerns in patients with anorectal malformations. Semin Pediatr Surg. 2010 May;19(2):139-45. Huppert J, Griffeth S, Breech L, Hillard P. Vaginal burn injury due to alkaline batteries. J Pediatr AdolescGynecol. 2009 Oct;22(5):e133-6.
Levitt MA, Bischoff A, Breech L, Peña A. Rectovestibular fistula − rarely recognized associated gynecologic anomalies. J Pediatr Surg. 2009 Jun;44(6):1261-7; discussion 1267. Breech LL, Laufer MR. Müllerian anomalies. Obstet Gynecol Clin North Am. 2009 Mar;36(1):47-68. Review. Miller RJ, Breech LL. Surgical correction of vaginal anomalies. Clin Obstet Gynecol. 2008 Jun;51(2):223-36. Review. Linam LE, Darolia R, Naffaa LN, Breech LL, O'hara SM, Hillard PJ, Huppert JS. US findings of adnexal torsion in children and adolescents: size really does matter. Pediatr Radiol. 2007 Oct;37(10):1013-9.
Charles T. Mehlman, DO, MPH Director, Musculoskeletal Outcomes Research 513-636-4785 firstname.lastname@example.org
Director, Musculoskeletal Outcomes Research
Co-Director, Brachial Plexus Center
Professor, Division of Pediatric Surgery
Musculoskeletal outcomes research; orthopaedic trauma; bone tumors; arthroscopic surgery; shoulder and elbow surgery; spine surgery; foot and ankle surgery; limb deficiencies in children
Pediatric outcomes: quality of life following traumatic injury, traction and casting versus flexible intramedullary nailing of femoral fractures in children; brachial plexus injuries; effectiveness of video-assisted thoracoscopic surgery in the management of pediatric spinal deformity biomechanical study of Nancy nails, outcomes following pediatric thoracolumbar spinal trauma; medical soft-tissue release and petrie casting for the treatment of Legg-Calve-Perthes disease; perioperative complications associated with operative treatment of supracondylar humeral fractures in children; undisplaced fractures of the distal radius and ulna in children -- risk factors for displacement; talus fractures in children; complications associated with the use of meniscal arrows in children; effectiveness of halo-femoral traction in the management of severe spinal deformity; orthopaedic injuries in children secondary to airbag deployment; buckle fractures of the distal radius and ulna -- risk factors for displacement; hip problems associated with Rubinstein-Taybi syndrome and effectiveness of flexible intramedullary nailing of pediatric tibia fractures
Talbert RJ, Michaud LJ, Mehlman CT, Kinnett DG, Laor T, Foad SL, Schnell B, Salisbury S. EMG and MRI are Independently Related to Shoulder External Rotation Function in Neonatal Brachial Plexus Palsy. J Pediatr Orthop. 2011 Mar;31(2):194-204.
Parikh SN, Wells L, Mehlman CT, Scherl SA. Management of fractures in adolescents. J Bone Joint Surg Am. 2010 Dec 15;92(18):2947-58. Review.
Bowman EN, Mehlman CT, Lindsell CJ, Tamai J. Nonoperative treatment of both-bone forearm shaft fractures in children: predictors of early radiographic failure. J Pediatr Orthop. 2011 Jan-Feb;31(1):23-32.
Gammon SR, Mehlman CT, Chan W, Heifetz J, Durrett G, Wall EJ. A comparison of thoracolumbosacral orthoses and SpineCor treatment of adolescent idiopathic scoliosis patients using the Scoliosis Research Society standardized criteria. J Pediatr Orthop. 2010 Sep;30(6):531-8.
White L, Mehlman CT, Crawford AH. Perfused, pulseless, and puzzling: a systematic review of vascular injuries in pediatric supracondylar humerus fractures and results of a POSNA questionnaire. J Pediatr Orthop. 2010 Jun;30(4):328-35. Review.
Babal JC, Mehlman CT, Klein G. Nerve injuries associated with pediatric supracondylar humeral fractures: a meta-analysis. J Pediatr Orthop. 2010 Apr-May;30(3):253-63.
McCarty ME, Mehlman CT, Tamai J, Do TT, Crawford AH, Klein G. Spondylolisthesis: intraobserver and interobserver reliability with regard to the measurement of slip percentage. J Pediatr Orthop. 2009 Oct-Nov;29(7):755-9.
McGraw MA, Mehlman CT, Lindsell CJ, Kirby CL. Postnatal growth of the clavicle: birth to 18 years of age. J Pediatr Orthop. 2009 Dec;29(8):937-43.
Mehlman CT, Yihua G, Bochang C, Zhigang W. Operative treatment of completely displaced clavicle shaft fractures in children. J Pediatr Orthop. 2009 Dec;29(8):851-5.
Foad SL, Mehlman CT, Foad MB, Lippert WC. Prognosis following neonatal brachial plexus palsy: an evidence-based review. J Child Orthop. 2009 Nov 3.
Peter F. Sturm, MD Director, Crawford Spine Center 513-636-4785 email@example.com
Director, Crawford Spine Center
Alvin H. Crawford Chair of Spine Surgery
MD: New York University School of Medicine, New York, NY, 1981.
Residency: Orthopaedic Surgery Mount Sinai Hospital, New York, NY, 1986.
Fellowship: Russ Spinal Surgery, Ottawa Civic Hospital Ottawa, Ontario, Canada, 1987; Pediatric Orthopaedic Surgery, The Children's Hospital Boston, Boston, MA, 1988.
Certification: Orthopaedic Surgery, 1990, 1999, 2010.
Carreon LY, Sanders JO, Diab M, Sturm PF, Sucato DJ; Spinal Deformity Study Group. Patient satisfaction after surgical correction of adolescent idiopathic scoliosis. Spine (Phila Pa 1976). 2011 Jan 8.
Sturm PF, Zaharski K, Riordan M, Hassani S. Anticipating complications in pediatric deformity surgery: is any preparation necessary in healthy children? Spine (Phila Pa 1976). 2010 Dec 1;35(25):2211-4.
Carreon LY, Sanders JO, Diab M, Sucato DJ, Sturm PF, Glassman SD; Spinal Deformity Study Group. The minimum clinically important difference in Scoliosis Research Society-22 Appearance, Activity, And Pain domains after surgical correction of adolescent idiopathic scoliosis. Spine (Phila Pa 1976). 2010 Nov 1;35(23):2079-83.
Sanders JO, Carreon LY, Sucato DJ, Sturm PF, Diab M; Spinal Deformity Study Group. Preoperative and perioperative factors effect on adolescent idiopathic scoliosis surgical outcomes. Spine (Phila Pa 1976). 2010 Sep 15;35(20):1867-71. Bustamante Valles KD, Long JT, Riedel SA, Graf A, Krzak J, Hassani S, Riordan M, Zaharski K, Sturm PF, Harris GF. Analysis of postural stability following posterior spinal fusion in adolescents with idiopathic scoliosis. Stud Health Technol Inform. 2010;158:127-31.
Cahill PJ, Warnick DE, Lee MJ, Gaughan J, Vogel LE, Hammerberg KW, Sturm PF. Infection after spinal fusion for pediatric spinal deformity: thirty years of experience at a single institution. Spine (Phila Pa 1976). 2010 May 20;35(12):1211-7. Slavens BA, Sturm PF, Harris GF. Upper extremity inverse dynamics model for crutch-assisted gait assessment. J Biomech. 2010 Jul 20;43(10):2026-31. Valles KD, Long JT, Riedel SA, Graf A, Krzak J, Hassani S, Sturm PF, Harris GF. Using a bi-planar postural stability model to assess children with scoliosis. Conf Proc IEEE Eng Med Biol Soc. 2009;2009:7010-3. Slavens BA, Sturm PF, Bajournaite R, Harris GF. Upper extremity dynamics during Lofstrand crutch-assisted gait in children with myelomeningocele. Gait Posture. 2009 Nov;30(4):511-7. Sanders JO, D'Astous J, Fitzgerald M, Khoury JG, Kishan S, Sturm PF. Derotational casting for progressive infantile scoliosis. J Pediatr Orthop. 2009 Sep;29(6):581-7.
Margaret H. Collins, MD 513-636-4261 firstname.lastname@example.org
Professor, UC Department of Pathology & Laboratory Medicine
Pediatric gastrointestinal pathology; eosinophilic gastrointestinal diseases; biopsy analyses; primary study endpoints; novel therapies to treat eosinophilic esophagitis in children; disorders of bowel immunity; bowel motility disorders
BS: Fordham University, NY, 1972.
MD: Georgetown University, Washington, D.C., 1977.
Residency: Pathology, New York Hospital, NY, 1977-80; Pathology, Columbia-Presbyterian Medical Center, NY, 1980-83.
Fellowship: Research, New York Lung Association, Columbia-Presbyterian Medical Center, N.Y., 1983-85; Research, American Lung Association, Columbia-Presbyterian Medical Center, NY, 1985-87.
Certification: Pathology, 1981; Pediatric Pathology, 1991.
Nikolaidis NM, Kulkarni RM, Gray JK, Collins MH, Waltz SE. Ron receptor deficient alveolar myeloid cells exacerbate LPS-induced acute lung injury in the murine lung. Innate Immun. 2010 Nov 18.
Sherrill JD, Gao PS, Stucke EM, Blanchard C, Collins MH, Putnam PE, Franciosi JP, Kushner JP, Abonia JP, Assa'ad AH, Kovacic MB, Biagini Myers JM, Bochner BS, He H, Hershey GK, Martin LJ, Rothenberg ME. Variants of thymic stromal lymphopoietin and its receptor associate with eosinophilic esophagitis. J Allergy Clin Immunol. 2010 Jul;126(1):160-5.e3.
DeBrosse CW, Collins MH, Buckmeier Butz BK, Allen CL, King EC, Assa'ad AH, Abonia JP, Putnam PE, Rothenberg ME, Franciosi JP. Identification, epidemiology, and chronicity of pediatric esophageal eosinophilia, 1982-1999. J Allergy Clin Immunol. 2010 Jul;126(1):112-9.
Abonia JP, Blanchard C, Butz BB, Rainey HF, Collins MH, Stringer K, Putnam PE, Rothenberg ME. Involvement of mast cells in eosinophilic esophagitis. J Allergy Clin Immunol. 2010 Jul;126(1):140-9.
Caldwell JM, Blanchard C, Collins MH, Putnam PE, Kaul A, Aceves SS, Bouska CA, Rothenberg ME. Glucocorticoid-regulated genes in eosinophilic esophagitis: a role for FKBP51. J Allergy Clin Immunol. 2010 Apr;125(4):879-888.e8.
Rothenberg ME, Spergel JM, Sherrill JD, Annaiah K, Martin LJ, Cianferoni A, Gober L, Kim C, Glessner J, Frackelton E, Thomas K, Blanchard C, Liacouras C, Verma R, Aceves S, Collins MH, Brown-Whitehorn T, Putnam PE, Franciosi JP, Chiavacci RM, Grant SF, Abonia JP, Sleiman PM, Hakonarson H. Common variants at 5q22 associate with pediatric eosinophilic esophagitis. Nat Genet. 2010 Apr;42(4):289-91.
Blanchard C, Stucke EM, Burwinkel K, Caldwell JM, Collins MH, Ahrens A, Buckmeier BK, Jameson SC, Greenberg A, Kaul A, Franciosi JP, Kushner JP, Martin LJ, Putnam PE, Abonia JP, Wells SI, Rothenberg ME. Coordinate interaction between IL-13 and epithelial differentiation cluster genes in eosinophilic esophagitis. J Immunol. 2010 Apr 1;184(7):4033-41.
Miller SJ, Lan ZD, Hardiman A, Wu J, Kordich JJ, Patmore DM, Hegde RS, Cripe TP, Cancelas JA, Collins MH, Ratner N. Inhibition of Eyes Absent Homolog 4 expression induces malignant peripheral nerve sheath tumor necrosis. Oncogene. 2010 Jan 21;29(3):368-79.
Vicario M, Blanchard C, Stringer KF, Collins MH, Mingler MK, Ahrens A, Putnam PE, Abonia JP, Santos J, Rothenberg ME. Local B cells and IgE production in the oesophageal mucosa in eosinophilic oesophagitis. Gut. 2010 Jan;59(1):12-20.
Prosperi JR, Becher KR, Willson TA, Collins MH, Witte DP, Goss KH. The APC tumor suppressor is required for epithelial integrity in the mouse mammary gland. J Cell Physiol. 2009 Aug;220(2):319-31.
Richard G. Azizkhan, MD Surgeon-in-Chief; Lester W. Martin Chair of Pediatric Surgery 513-636-4576 email@example.com
Surgeon-in-Chief; Lester W. Martin Chair of Pediatric Surgery
Surgical Director Emeritus, Hemangioma and Vascular Malformation Program
Complex mediastinal airway disorders; surgical oncology; neonatal anomalies; chest wall deformities; vascular malformations; esophageal disorders; pediatric trauma; epidermolysis bullosa
Trauma systems; injury prevention; fetal lung development; vascular malformations; solid tumors in childhood
Dr. Richard Azizkhan is the founding director of the Hemangioma and Vascular Malformations Center and established the Vascular Anomalies Training Fellowship. Due to his vision for an interdisciplinary and coordinated effort to treat children with vascular anomalies, he recruited outstanding professionals from multiple disciplines to be part of HVMC team. He has over 30 years of surgical experience in treating children with complex vascular anomalies. He is the Surgeon-in-Chief at Cincinnati Children’s Hospital Medical Center, is the first occupant of the Lester W. Martin Chair of pediatric surgery, and is a professor of surgery and pediatrics at the University Of Cincinnati College Of Medicine.
Dr. Azizkhan obtained his medical degree from the Milton S. Hershey Center of Pennsylvania State University College of Medicine, completed his pediatric surgery residency at Johns Hopkins and his research fellowship at Harvard with Dr. Judah Folkman. He has published extensively and is author of more than 200 papers and chapters, and five books.
As an international advocate for children’s rights and health, Dr. Azizkhan has made significant clinical and basic research contributions in angiogenesis and vascular malformations, lung development, airway reconstruction, solid tumors, trauma and injury prevention. Dr. Azizkhan has served in leadership roles in numerous national and international surgical organizations including the American Academy of Pediatrics Surgical Section, American Pediatric Surgical Association, and the American College of Surgeons. He is the President of the World Federation of Associations of Pediatric Surgeons (WOFAPS) and has been active in establishing international medical education exchange programs and medical humanitarian activities in Central Europe, the Middle East, Latin America, Asia and Africa. He was awarded an Honorary PhD from Tuzla University in 2001 and honorary citizenship of Tuzla in 2006 for his continuing contributions to improving the health system in Bosnia and all of the former Yugoslavian republics. Dr. Azizkhan also received the Ghandi Gold medal in 2005 from the Indian Association of Pediatric Surgeons for his global impact.
MD: Doctor of Medicine, Milton S. Hershey Center of Pennsylvania State University College of Medicine Hershey, PA, 1972 to 1975.
Residency: Pediatric Surgery, Johns Hopkins Hospital, Baltimore, MD; Surgery, University of Virginia Medical Center, Charlottesville, VA.
Fellowship: Department of Surgery, Children's Hospital Medical Center, Harvard Medical School, Boston, MA.
Certification: General Surgery, 1984, recertified 1992; Pediatric Surgery, 1986, recertified 1993; Surgical Critical Care, 1989.
Rebeccah L. Brown, MD Associate Director, Trauma Services 513-636-4371 firstname.lastname@example.org
Associate Director, Trauma Services
General pediatric surgery; trauma; injury prevention; minimally invasive surgery; necrotizing enterocolitis; neonatal surgery; minimally invasive surgery; congenital hemolytic anemias; chest wall deformities
Rebeccah L. Brown, MD, received a Bachelor of Science in biology and Bachelor of Arts in chemistry at New Mexico State University in Las Cruces, NM, in 1986. She graduated from University of New Mexico School of Medicine in Albuquerque, NM, with an MD in 1990. She completed her general surgery residency at University of Cincinnati Medical Center, in Cincinnati, Ohio, in 1997.
During her general surgical training, she also performed two years of basic science and clinical research in burn injuries and wound healing at the Shriners Hospitals for Children -- Cincinnati. She also served as an extracorporeal membrane oxygenation (ECMO) fellow at Cincinnati Children's Hospital Medical Center.
After completion of general surgery training, Dr. Brown completed a two-year fellowship in pediatric surgery at Children's Hospital of Buffalo in Buffalo, NY. She returned to Cincinnati Children's, Ohio, as assistant professor of surgery and pediatrics. Her main research interest is trauma and injury prevention, and she is currently the assistant director of Trauma Services, the fellowship director for the Pediatric Trauma Fellowship, and the director and cofounder of the Buckle Up for Life or Abrochate a la Vida program funded by Toyota.
Dr. Brown's clinical interests besides trauma and injury prevention include general pediatric surgery, minimally invasive surgery, inflammatory bowel disease, and Hirschsprung's disease.
Dr. Brown is a member of multiple professional organizations including the American College of Surgeons, American Medical Association, American Medical Women's Association, American College of Surgeons -- Ohio Chapter, Cincinnati Pediatric Society, Mont Reid Surgical Society, American Pediatric Surgical Association, American Academy of Pediatrics - Surgical Section and Injury Prevention Section, Eastern Association for the Surgery and Trauma, and Pediatric Trauma Society.
MD: University of New Mexico School of Medicine, Albuquerque, N.M., 1990.
Residency: General Surgery, University of Cincinnati Hospital, Cincinnati, OH, 1997.
Fellowship: Shriners Burns Institute, Cincinnati, Ohio, 1992-1994; ECMO, Children's Hospital Medical Center, Cincinnati, Ohio, 1993-1994; Pediatric Surgery Fellow, Children's Hospital of Buffalo, Buffalo, NY, 1997-1999.
Certification: Board-certified General Surgery, 1998, 2007; board-certified, Pediatric Surgery, 2000, 2009.
A. Roshni Dasgupta, MD, MPH Pediatric Surgeon, Division of Pediatric General and Thoracic Surgery 513-636-4371 email@example.com
Pediatric Surgeon, Division of Pediatric General and Thoracic Surgery
Surgical oncology and vascular malformations; minimally invasive surgery; general pediatric surgery
Oncology and vascular malformations
Roshni Dasgupta, MD, MPH, is a surgeon and associate professor with the Hemangioma and Vascular Malformations Center. She has been involved with the HVMC team for the past eight years. Dr. Dasgupta obtained her medical degree at the University of Toronto. She finished her residency at Massachusetts General Hospital at Harvard Medical School. She completed a Rhodes Scholarship at the University of Oxford in Oxford England, followed by a Pediatric Surgery Fellowship at the Hospital for Sick Children in Toronto, Canada. She has also completed her Master of Public Health at the Harvard School of Public Health.
Dr. Dasgupta has authored multiple articles and book chapters on vascular anomalies and will be the next editor of the vascular anomalies edition of Seminars in Pediatric Surgery. She is interested in post-surgical long term outcomes of patients with vascular anomalies, as well as treatment and outcomes of hemangioma patients.
MD: University of Toronto, Toronto Canada, 1996.
Residency: Massachusetts General Hospital, Harvard Medical School 1996.-2003
Research Fellowship: University of Oxford, Oxford, England.
Fellowship: Hospital for Sick Children, Toronto, Canada.
MPH: Harvard School of Public Health, Boston, MA, 2009.
Hamilton TE, Barnhart D, Gow K, Ferrer F, Kandel J, Glick R, Dasgupta R, Naranjo A, He Y, Gratias E, Geller J, Ehrlich P. Inter-rater reliability of surgical reviews for AREN03B2: A COG renal tumor committee study. J Pediatr Surg. 2014 Jan;49(1):154-8.
Drolet BA, Trenor CC 3, Brandão LR, Chiu YE, Chun RH, Dasgupta R, Garzon MC, Hammill AM, Johnson CM, Tlougan B, Blei F, David M, Elluru R, Frieden IJ, Friedlander SF, Iacobas I, Jensen JN, King DM, Lee MT, Nelson S, Patel M, Pope E, Powell J, Seefeldt M, Siegel DH, Kelly M, Adams DM. Consensus-derived practice standards plan for complicated Kaposiform hemangioendothelioma. J Pediatr. 2013 Jul;163(1):285-91.
Burke ME, Lyden ER, Meza, JL, Ladas EJ, Dasgupta R, Wiegner EA, Arndt CA. Does body mass index at diagnosis or weight change during therapy predict toxicity or survival in intermediate risk rhabdomyosarcoma? A report from the Children’s Oncology Group Soft Tissue Sarcoma Committee. Pediatr Blood Cancer. 2013 May;60(5):748-53.
Murrell Z, Dasgupta R. What predicts the risk of recurrent lung metastases? J Pediatr Surg. 2013 May;48(5):1020-4.
Chen W, Gupta A, Adams D, Patel M, Dasgupta R. Generalized lymphatic malformation with chylothorax: long-term management of a highly morbid condition in a pediatric patient. J Pediatr Surg. 2013 Mar;48(3):e9-e12.
Dasgupta R, Rodeberg DA. Update on rhabdomyosarcoma. Semin Pediatr Surg. 2012 Feb; 21(1):68-78.
Rymeski B, Burns K, Nagarajan R, Correll J, Kent D, O'Brien M, Perentesis JP, Dasgupta R. Long-term complications after staging laparotomy for Hodgkin lymphoma. J Clin Oncol 30, 2012.
Richard A. Falcone Jr., MD, MPH Director, Trauma Services 513-636-4371 firstname.lastname@example.org
Director, Trauma Services
Pediatric injury prevention and outcomes; trauma education; management of colorectal disorders; inflammatory bowel disease; minimally invasive surgery; surgical oncology; extracorporeal life support (ECLS)
Nance ML, Krummel TM, Oldham KT, Falcone R JR, Trauma Committee of the American Pediatric Surgical Association. Firearm injuries and Children: A Policy Statement of the American Pediatric Surgical Association. J Am Coll Surg. 2013 Nov; 217(5): 940-6.
Patterson M, Geis G, Falcone R, LeMaster T, Wears R. In situ simulation: detection of safety threats and teamwork training in a high risk emergency department. BMJ Qual Saf. 2013 Jun;22(6):468-77.
Jurickova I, Collins MH, Chalk C, Seese A, Bezold R, Lake K, von Allmen D, Frischer JS, Falcone RA, Trapnell BC, Denson LA. Paediatric Crohn disease patients with stricturing behaviour exhibit ileal granulocyte-macrophage colony-stimulating factor (GM-CSF) autoantibody production and reduced neutrophil bacterial killing and GM-CSF bioactivity. Clin Exp Immunol. 2013 Jun;172(3)455-65.
Beaudin M, Maugans T, St-Vil D, Falcone RA Jr. Inappropriate use of infant seating devices increases risks of injury. J Pediatr Surg. 2013 May;48(5):1071-6.
Cook R, Gillespie GL, Kronk, R, Daugherty M, Moody SM, Allen LJ, Shebesta KB, Falcone RA. Effect of an Educational Intervention on Nursing Staff Knowledge, Confidence, and Practice in the Care of Children with Mild Traumatic Brain Injury. J Neurosci Nurs. 2013 Apr;45(2):108-18.
Kelleher DC, Renaud EJ, Ehrlich PF, Burd RS; Pediatric Trauma Society Guidelines Committee. Guidelines for alcohol screening in adolescent trauma patients: a report from the Pediatric Trauma Society Guidelines Committee. J Trauma Acute Care Surg. 2013 Feb;74(2):671-82.
Daugherty MC, Mehlman CT, Moody S, LeMaster T, Falcone RA Jr . Significant rate of misuse of the Hare traction splint for children with femoral shaft fractures. J Emerg Nurs. 2013 Jan;39(1):97-103.
Chatoorgoon K, Brown RL, Garcia VF, Falcone RA. Role of computed tomography and clinical findings in pediatric blunt intestinal injury: a multi-center study. Pediatr Emerg Care. 2012 Dec;28(12):1338-42.
Beaudin M, Daugherty M, Geis G, Moody S, Brown RL, Garcia VF, Falcone RA Jr. Assessment of factors associated with the delayed transfer of pediatric trauma patients: an emergency physician survey. Pediatr Emerg Care. 2012 Aug;28(8):758-63.
Falcone RA Jr, Haas L, King E, Moody S, Crow J, Moss A, Gaines B, McKenna C, Gourlay DM, Werner C, Meagher DP Jr, Schwing L, Garcia N, Brown D, Groner JI, Haley K, Deross A, Cizmar L, Armola R. A multicenter prospective analysis of pediatric trauma activation criteria routinely used in addition to the six criteria of the American College of Surgeons. J Trauma Acute Care Surg. 2012 Aug;73(2):377-84.
Victor F. Garcia, MD, FACS, FAAP Founding Director, Trauma Services 513-636-4371 email@example.com
Founding Director, Trauma Services
Pediatric injury research and control; chest-wall deformities; minimally invasive surgery (use of the laparoscope and thoracoscope to diagnose and treat surgical diseases); surgical weight loss; minority health care
Victor Garcia, MD, graduated from West Point, the University of Pennsylvania School of Medicine, studied pediatric surgery under C Everett Koop, and was Walter Reed’s chief of General/Pediatric Surgery.
Vic founded Children’s Trauma Center and led the effort to establish the country’s first Pediatric Weight Loss Surgery Center.
For his ongoing work to eliminate childhood health and social disparities, he has received numerous awards and commendations to include the Martin Luther King Humanitarian Award and the National Jefferson Award.
Vic has an uncompromising belief in the power of systems thinking and stakeholder engagement to solve society’s most intractable problems.
BS: Engineering, United States Military Academy, 1964-1968.
MD: University of Pennsylvania, School of Medicine, Philadelphia, PA, 1974.Residency: Walter Reed Army Medical Center, Washington, DC, 1978. Fellowship: Children's Hospital of Philadelphia, Philadelphia, PA. Certification: Surgery, 1979; Pediatric Surgery, 1982; Surgical Critical Care, 1991.
Chatoorgoon K, Brown RL, Garcia VF, Falcone, RA. Role of Computed Tomography and Clinical Findings in Pediatric Blunt Intestinal Injury. Pediatric Emergency Care. 2012;28 (12): 1338-1342.
Beaudin M, Daugherty M, Geis G, Moody S, Brown RL, Garcia VF, Falcone RA. Assessment of Factors Associated with the Delayed Transfer of Pediatric Trauma Patients. Pediatric Emergency Care. 2012;28 (8): 758-63.
Goldberg J, McClaine RJ, Cook B, Garcia VF, Brown RL, Crone K, Falcone RA. Use of a mild traumatic brain injury guideline to reduce inpatient hospital imaging and charges. Journal of Pediatric Surgery. 2011;46: 1777-1783.
McClaine RJ, Garcia VF. Unnatural Causes: Social Determinants of Child Health and Well-being. The Pediatric Forum, American Medical Association. 2011;165 (5): 476.
Chatoorgoon K, Huezo K, Rangel E, Francios N, Schweer L, Daugherty M, Koehn M, Richetts C, Brown RL, Garcia VF, Falcone RA. Unnecessary Imaging, Not Hospital Distance, or Transportation Mode Impacts Delays in the Transfer of Injured Children. Pediatric Emergency Care. 2010;26 (7): 481-486.
Martin CA, Care M, Rangel EL, Brown RL, Garcia VF, Falcone RA. Severity of head computed tomography scan findings fail to explain racial differences in mortality following child abuse. American Journal of Surgery. 2010;199 (2): 210-215.
Ippisch HM, Inge TH, Daniels SR, Wang B, Khoury PR, Witt SA, Glascock BJ, Garcia VF, Kimball TR. Reversibility of Cardiac Abnormalities in Morbidly Obese Adolescents. Journal of the American College of Cardiology. 2008;51(14): 1342-1348.
Falcone RA , Martin C, Brown RL, Garcia VF. Despite overall low pediatric head injury mortality, disparities exist between races. Journal of Pediatric Surgery. 2008;43(10), 1858-1864.
Falcone RA, Daugherty M, Schweer L, Patterson M, Brown RL, Garcia VF. Multidisciplinary pediatric trauma team training using high-fidelity trauma simulation. Journal of Pediatric Surgery. 2008;43(6), 1065-1071.
Rangel SJ, Martin CA, Brown RL, Garcia VF, Falcone RA. Alarming trends in the improper use of motor vehicle restraints in children: implications for public policy and the development of race-based strategies for improving compliance. Journal of Pediatric Surgery. 2008;43(1), 200-207.
Thomas H. Inge, MD, PhD, FACS, FAAP Surgical Director, Surgical Weight Loss Program for Teens 513-636-4371 firstname.lastname@example.org
Surgical Director, Surgical Weight Loss Program for Teens
Director, Center for Bariatric Research and Innovation
Attending Surgeon, Cincinnati Children’s Hospital Medical Center
Thomas H. Inge, MD, PhD, is a Virginia native who grew up in a rural, farming community in Dinwiddie County. He received his BS in biology at the College of William and Mary in Williamsburg, VA, in 1987. Dr. Inge entered the Medical College of Virginia in Richmond, VA, in the Medical Scientist Training Program, and pursued degrees in microbiology/immunology and medicine. He graduated with MD and PhD degrees in 1993.
Dr. Inge received his surgical training at Stanford University Hospital in Palo Alto, CA, where he developed an interest in pediatric surgery. At the completion of his chief resident year in 1998, he moved to Birmingham, AL, for specialty training in pediatric surgery at the Children's Hospital of Alabama, with an emphasis on pediatric minimally invasive surgery. Dr. Inge became a full-time member of the surgical staff at Cincinnati Children's Hospital Medical Center and faculty member of the University of Cincinnati College of Medicine, Department of Surgery, Division of Pediatric Surgery, in July 2000.
In addition to general pediatric surgical practice, Dr. Inge's clinical research focus is related to bariatric surgery in adolescents. He is the surgical director of the Surgical Weight Loss Program for Teens, offering surgery for overweight adolescents with complications from their excess weight. He has served as a consultant to the Food and Drug Administration for projects related to device treatment of pediatric obesity. He is also the Principal Investigator of two research projects funded by National Institutes of Health (NIH) and co-investigator of another NIH funded project examining the role of surgery for management of adolescent obesity. He currently serves as Study Chairman of Teen-LABS, a multicenter research consortium examining outcomes of adolescent bariatric surgery.
Dr. Inge has given over 50 invited lectures nationally and internationally over the past four years, has mentored more than a dozen fellows and students, and has authored more than 70 published chapters and manuscripts.
BS: College of William and Mary, Williamsburg, VA, 1987.MD: Medical College of Virginia, Virginia Commonwealth University, Richmond, VA, 1993.PhD: Virginia Commonwealth University, Richmond, VA, 1993.Residency: Stanford University Hospital, Stanford, CA, 1998.
Fellowship: Children's Hospital of Alabama, Birmingham, AL, 2000.
Board Certification: Diplomate of the American Board of Surgery, December 1999; Certification in Pediatric Surgery, American Board of Surgery, March 2002.
Zeller MH, Jenkins TM, Helmrath M, Brandt ML, Michalsky MP, Harmon CM,
Courcoulas A, Horlick M, Xanthakos SA, Dolan L, Mitsnefes M, Barnett SJ,
Buncher R, for the Teen-LABS Consortium. Perioperative Outcomes of Adolescents
Undergoing Bariatric Surgery: The Teen-Longitudinal Assessment of Bariatric
Surgery (Teen-LABS) Study. JAMA Pediatr. 2014 Jan;168(1):47-53; PubMed PMID:
M, Boillot A, Muzard L, Poitou C, Oppert JM, Barsamian C, Gatta B, Müller H,
Weismann D, Rottembourg D, Inge T, Veyrie N, Carette C, Czernichow S. Bariatric surgery following treatment for
craniopharyngioma: a systematic review and individual-level data meta-analysis.
J Clin Endocrinol Metab. 2013 Mar 26. [Epub ahead of print] PubMed PMID:
Kelly AS, Barlow SE, Rao G, Inge TH, Hayman LL,
Steinberger J, Urbina EM, Ewing LJ, Daniels SR. Severe obesity in children and
adolescents: identification, associated health risks, and treatment approaches:
a scientific statement from the American Heart Association. Circulation. 2013
TH, King WC, Jenkins TM, Courcoulas AP, Mitsnefes M, Flum DR, Wolfe BM, Pomp A,
Dakin GF, Khandelwal S, Zeller MH, Horlick M, Pender JR, Chen JY, Daniels SR. The Effect of Obesity in Adolescence on Adult Health Status. Pediatrics. 2013
Dec;132(6):1098-104; PubMed PMID: 24249816.
D. Kaulfers, Judy A. Bean, Thomas H. Inge, Lawrence M. Dolan, Heidi J. Kalkwarf. Bone Loss in Adolescents after Bariatric
Surgery. Pediatrics. 2011;
127(4):e956-61. PMCID: PMC3065081.
TH, Jenkins TM, Zeller M, Dolan L, Daniels SR, Garcia VF, Brandt ML, Bean J,
Gamm K, Xanthakos SA. Baseline BMI is a strong predictor of nadir BMI after
adolescent gastric bypass. J Pediatr. 2010; 156(1):103. PMID 19775700.
Inge TH, Miyano G, Bean J, Helmrath
M, Courcoulas A, Harmon CM, Chen MK, Wilson K, Daniels SR, Garcia VF, Brandt
ML, Dolan LM. Reversal
of type 2 diabetes mellitus and improvements in cardiovascular risk factors
after surgical weight loss in adolescents. Pediatrics. 2009 Jan;123(1):214-22.
PubMed PMID: 19117885.
JS, Lenders CM, Dionne EA, Hoppin AG, Hsu GL, Inge TH, Lawlor DF, Marino MF,
Meyers AF, Rosenblum JL, Sanchez VM. Best practice updates for
pediatric/adolescent weight loss surgery. Obesity (Silver Spring). 2009
May;17(5):901-10. Feb 19.
M. Ippisch, Thomas H. Inge, Stephen R. Daniels, Baiyang Wang, Philip R. Khoury,
Sandra A. Witt, Betty J. Glascock, Victor F. Garcia, Thomas R. Kimball. Reversibility of Cardiac Abnormalities in Extremely Overweight
Adolescents. Journal of the American College of Cardiology 2008 Apr
WS, Inge TH, Burd RS. Bariatric surgery in adolescents: recent national trends
in use and in-hospital outcome. Archives
of Pediatric and Adolescent Medicine. 2007 Mar;161(3):217-21.
Sundeep G. Keswani, MD Pediatric Surgeon, Division of General, Thoracic and Fetal Surgery 513-803-2219
Pediatric Surgeon, Division of General, Thoracic and Fetal Surgery
Fetal Surgeon, Cincinnati Fetal Center
Director, Pediatric Advanced Wound Care and Skin Services
Gene therapy applications; bone marrow contribution to tissue repair; fetal diagnosis and treatment.
Visit the Keswani Lab.
Dr. Sundeep G. Keswani is a pediatric and fetal surgeon. He is also the director of the Pediatric Advanced Wound Care and Skin Service (PAWS), which is a state-of-the-art wound care center devoted to the care of children. Dr. Keswani is the lead principal investigator in the Cincinnati Children’s Wound Healing Research Group, which is an NIH-funded laboratory that focuses on understanding the molecular mechanisms which underlie the fetus’ ability to regeneratively heal wounds with the goal of developing novel therapeutics to achieve regenerative wound healing in postnatal tissue.
Alice King MD, Swathi Balaji PhD, Louis D. Le MD, Emily Marsh, Timothy M. Crombleholme MD, Sundeep G. Keswani MD. Interleukin-10 Regulates Fetal Extracellular Matrix Hyaluronan Production. Journal of Pediatric Surgery. (In press).
Visscher M, King A, Nie AM, Schaffer P, Taylor T, Pruitt D, Giaccone MJ, Ashby M, Keswani S. A Quality-Improvement Collaborative Project to Reduce Pressure Ulcers in PICUs. Pediatrics. 2013 Jun;131(6):e1950-60.
Keswani SG, Balaji S, Le LD, Leung A, Parvadia JK, Frischer J, Yamano S, Taichman N, Crombleholme TM. Role of salivary vascular endothelial growth factor (VEGF) in palatal mucosal wound healing. Wound Repair Regen. 2013 Jun 11.
King A, Balaji S, Marsh E, Le LD, Shaaban AF, Crombleholme TM, Keswani SG. Interleukin-10 regulates the fetal hyaluronan-rich extracellular matrix via a STAT3-dependent mechanism. J Surg Res. 2013 Apr 24.
Balaji S, King A, Dhamija Y, Le LD, Shaaban AF, Crombleholme TM, Keswani SG. Pseudotyped adeno-associated viral vectors for gene transfer in dermal fibroblasts: implications for wound-healing applications. J Surg Res. 2013 Apr 3.
Keswani SG, Balaji S, Le L, Leung A, Katz AB, Lim FY, Habli M, Jones HN, Wilson JM, Crombleholme TM. Pseudotyped AAV vector-mediated gene transfer in a human fetal trachea xenograft model: implications for in utero gene therapy for cystic fibrosis. PLoS One. 2012;7(8):e43633.
Keswani SG, Balaji S, Le L, Leung A, Lim FY, Habli M, Jones HN, Wilson JM, Crombleholme TM. Pseudotyped adeno-associated viral vector tropism and transduction efficiencies in murine wound healing. Wound Repair Regen. 2012 Jul-Aug;20(4):592-600.
Gordon A, Kozin ED, Keswani SG, Vaikunth SS, Katz AB, Zoltick PW, Favata M, Radu AP, Soslowsky LJ, Herlyn M, Crombleholme TM. Permissive environment in postnatal wounds induced by adenoviral-mediated overexpression of the anti-inflammatory cytokine interleukin-10 prevents scar formation. Wound Repair Regen. 2008 Jan-Feb;16(1):70-9.
Javazon EH, Keswani SG, Badillo AT, Crombleholme TM, Zoltick PW, Radu AP, Kozin ED, Beggs K, Malik AA, Flake AW. Enhanced epithelial gap closure and increased angiogenesis in wounds of diabetic mice treated with adult murine bone marrow stromal progenitor cells. Wound Repair Regen. 2007 May-Jun;15(3):350-9.
Keswani SG, Katz AB, Lim FY, Zoltick P, Radu A, Alaee D, Herlyn M, Crombleholme TM. Adenoviral mediated gene transfer of PDGF-B enhances wound healing in type I and type II diabetic wounds. Wound Repair Regen. 2004 Sep-Oct;12(5):497-504.
Foong-Yen Lim, MD Surgical Director, Cincinnati Fetal Center 513-636-4371 email@example.com
Surgical Director, Cincinnati Fetal Center
Open fetal surgery and fetoscopic surgery; ex-utero intrapartum treatment (EXIT); congenital high airway obstruction syndrome (CHAOS); congenital diaphragmatic hernia (CDH); fetal gene therapy; neonatal surgery; thoracic surgery; minimally invasive surgery
Visit the Lim Lab.
Jose L. Peiro, MD Endoscopic Fetal Surgery Director, Cincinnati Fetal Center 513-636-6259 jose.peiroIbanez@cchmc.org
Endoscopic Fetal Surgery Director, Cincinnati Fetal Center
Pediatric Surgeon, Division of General and Thoracic Surgery
Neonatal surgery; fetal surgery
MD: Medical School at Universidad Autonoma de Barcelona, Barcelona, Spain, 1989.
MBA: Health and Hospital Management, Universitat Oberta de Catalunya (UOC), Barcelona, Spain, 2010-2012.
Residency: Pediatric Surgery, Hospital Vall Hebron (UAB), Barcelona, Spain, 1991-1995.
Observership: Fetal Surgery, The Children's Hospital of Philadelphia, Philadelphia, PA, 2001.
Burgos L, Encinas JL, García-Cabezas MA, Peiró JL, López-Santamaría M, Jaureguízar E. Bladder Changes After Several Coverage Modalities in the Surgically Induced Model of Myelomeningocele in Lambs. Actas Urol Esp. 2014 January - February;38(1):55-61.
Peiro JL, Fontecha CG, Ruano R, Esteves M, Fonseca C, Marotta M, Haeri S, Belfort MA. Single-Access Fetal Endoscopy (SAFE) for myelomeningocele in sheep model I: amniotic carbon dioxide gas approach. Surg Endosc. 2013 Oct;27(10):3835-40.
Ruano R, Peiro JL, da Silva MM, Campos JA, Carreras E, Tannuri U, Zugaib M. Early fetoscopic tracheal occlusion for extremely severe pulmonary hypoplasia in isolated congenital diaphragmatic hernia: preliminary results. Ultrasound Obstet Gynecol. 2013 Jul;42(1):70-6.
Peiró JL, Encinas JL. Fetal surgery of myelomeningocele: from experimental results to clinical evidence. Cir Pediatr. 2012 Jan;25(1):1-3.
Encinas JL, García-Cabezas MÁ, Barkovich J, Fontecha CG, Peiró JL, Soto GM, Borrell V, Reillo I, López-Santamaría M, Tovar JA, Farmer DL. Maldevelopment of the cerebral cortex in the surgically induced model of myelomeningocele: implications for fetal neurosurgery. J Pediatr Surg. 2011 Apr;46(4):713-22.
Fontecha CG, Peiro JL, Sevilla JJ, Aguirre M, Soldado F, Fresno L, Fonseca C, Chacaltana A, Martinez V. Fetoscopic coverage of experimental myelomeningocele in sheep using a patch with surgical sealant. Eur J Obstet Gynecol Reprod Biol. 2011 Jun;156(2):171-6.
Peiró JL, Carreras E, Guillén G, Arévalo S, Sánchez-Durán MA, Higueras T, Castillo F, Marhuenda C, Lloret J, Martínez-Ibáñez V. Therapeutic indications of fetoscopy: a 5-year institutional experience. J Laparoendosc Adv Surg Tech A. 2009 Apr;19(2):229-36.
Castillo F, Peiró JL, Carreras E, Ruiz C, Linde A, Ribes C, Creus A. The exit procedure (ex-utero intrapartum treatment): management of giant fetal cervical teratoma. J Perinat Med. 2007;35(6):553-5.
Aimen F. Shaaban, MD Director, Center for Fetal Cellular and Molecular Therapy 513-636-9942