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Here at the Cincinnati Center for Eosinophilic Disorders (CCED)
we hear many great questions about eosinophilic disorders from patients and
families. Below are a few answers to commonly asked questions. We also provide
questions to ask your treating physician in your community.
The eosinophils are sometimes elevated in the blood of individuals with eosinophilic gastrointestinal disorders (EGIDs) (in less than half of patients), and the blood eosinophil levels generally correlate with the severity of tissue disease. Thus, the eosinophil levels in the blood often return to normal.
A variety of foods can be associated with eosinophilic gastrointestinal disorders (EGIDs). Unlike classic anaphylaxis, there appears to be a broader range of foods identified as culprits. This area is under active research investigation.
It is important to know whether the increased eosinophils were found only in the esophagus, in the stomach, in the duodenum or in all of them. If the esophagus is affected, it is also essential to know whether it was the lower part only, the upper part only or both. This information will help in the decision making (Is it eosinophilic esophagitis (EoE)? Is it gastroesophageal reflux disease (GERD)? Is it eosinophilic gastroenteritis (EGE)?
More than 15 eosinophils per high power field (in the microscope) in esophageal biopsies are suggestive of primary eosinophilic esophagitis (EoE) while less than that are typically associated with gastroesophageal reflux disease (GERD).
A good percentage of patients with eosinophilic disorders of the gastrointestinal tract have food allergies. This area needs to be thoroughly evaluated by a doctor who is specialized in allergy and immunology.
Many disorders are associated with increased numbers in eosinophils in the gut. A complete history and physical exam plus associated tests should narrow the diagnosis.
The Cincinnati Center for Eosinophilic Disorders (CCED) also provides answers to common questions about the Psychological Effects of Eosinophilic Disorders.
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