Cincinnati Center for Eosinophilic Disorders
Eosinophilic Disorders | Research and Publications

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Ongoing Research: A Critical Need

Researchers at the Cincinnati Center for Eosinophilic Disorders (CCED) are worldwide leaders in the field. Our research involves basic, clinical and translational studies to determine the reason for the current epidemic of eosinophilic disorders and to develop diagnostics and a cure for the disease.

Because of our growing knowledge and ever improving technology, we have an unprecedented ability to make strides in our understanding of these diseases. We are currently studying compounds that might block eosinophil production, as we strive to develop the next and best treatment for eosinophil-associated medical disorders. Read our research and see what we have learned about these diseases so far and what we still need to learn.

CCED Research

We have a dedicated CCED research center and a comprehensive clinic for children and adults with eosinophilic disorders.

CCED Clinical Studies

We are actively conducting research to help understand and improve outcomes for patients with eosinophilic disorders. For research inquiries, contact the CCED at ccedresearch@cchmc.org.

Research-to-Therapeutic Pipeline

Developing new treatments and cures is an involved process that requires significant time and investment, especially during the fundamental stages of basic research and discovery validation, which are a major priority of the CCED. The CCED has a critical role in this process, working tirelessly on each stage, and has already had a key role in the development of molecular diagnostics for EoE, eosinophilic gastritis (EoG) and eosinophilic colitis (EoC) and therapeutic strategies for eosinophilic disorders such as eosinophilic esophagitis (EoE) and hypereosinophilic syndrome (HES). Current therapeutics for eosinophilic conditions primarily act to suppress the inflammatory response; modulate the epithelial barrier, allergen sensing, or microbiome; or inhibit eosinophil functions, such as eosinophil recruitment to the tissue, activation or survival.

Suggested Literature

Doctors who study eosinophils at Cincinnati Children's recommend the following journal articles for more information about research about eosinophilic disorders.

Publications

2022

Safroneeva E, Pan Z, King E, Martin LJ, Collins MH, Yang GY, Capocelli KE, Arva NC, Abonia JP, Atkins D, Bonis PA, Dellon ES, Falk GW, Gonsalves N, Gupta SK, Hirano I, Leung J, Menard-Katcher PA, Mukkada VA, Schoepfer AM, Spergel JM, Wershil BK, Rothenberg ME, Aceves SS, Furuta GT; Consortium of Eosinophilic Gastrointestinal Disease Researchers. Long-Lasting Dissociation of esophageal eosinophilia and symptoms after dilation in adults with eosinophilic esophagitis. Clin Gastroenterol Hepatol. 2022 Apr;20(4):766-775.e4. doi: 10.1016/j.cgh.2021.05.049. PMID: 34062314; PMCID: PMC8628021.

Rothenberg ME, Hottinger SKB, Gonsalves N, Furuta GT, Collins MH, Talley NJ, Peterson K, Menard-Katcher C, Smith M, Hirano I, Genta RM, Chehade M, Gupta SK, Spergel JM, Aceves SS, Dellon ES. Impressions and aspirations from the FDA GREAT VI Workshop on eosinophilic gastrointestinal disorders beyond eosinophilic esophagitis and perspectives for progress in the field. J Allergy Clin Immunol. 2022 Mar;149(3):844-853. doi: 10.1016/j.jaci.2021.12.768. PMID: 34953790; PMCID: PMC8901475.

Dellon ES, Gonsalves N, Rothenberg ME, Hirano I, Chehade M, Peterson KA, Falk GW, Murray JA, Gehman LT, Chang AT, Singh B, Rasmussen HS, Genta RM. Determination of biopsy yield that optimally detects eosinophilic gastritis and/or duodenitis in a randomized trial of lirentelimab. Clin Gastroenterol Hepatol. 2022 Mar;20(3):535-545.e15. doi: 10.1016/j.cgh.2021.05.053. PMID: 34089846; PMCID: PMC8636525.

Hirano I, Collins MH, Katzka DA, Mukkada VA, Falk GW, Morey R, Desai NK, Lan L, Williams J, Dellon ES; ORBIT1/SHP621-301 Investigators. Budesonide oral suspension improves outcomes in patients with eosinophilic esophagitis: results from a phase 3 trial. Clin Gastroenterol Hepatol. 2022 Mar;20(3):525-534.e10. doi: 10.1016/j.cgh.2021.04.022. PMID: 33887475.

Min S, Shoda T, Wen T, Rothenberg ME. Diagnostic merits of the eosinophilic esophagitis diagnostic panel from a single esophageal biopsy. J Allergy Clin Immunol. 2022 Feb;149(2):782-787.e1. doi: 10.1016/j.jaci.2021.07.032. PMID: 34380050; PMCID: PMC8821114.

Brusilovsky M, Bao R, Rochman M, Kemter AM, Nagler CR, Rothenberg ME. Host-microbiota interactions in the esophagus during homeostasis and allergic inflammation. Gastroenterology. 2022 Feb;162(2):521-534.e8. doi: 10.1053/j.gastro.2021.10.002. PMID: 34627858.

Hiremath G, Sun L, Correa H, Acra S, Collins MH, Bonis P, Arva NC, Capocelli KE, Falk GW, King E, Gonsalves N, Gupta SK, Hirano I, Mukkada VA, Martin LJ, Putnam PE, Spergel JM, Wechsler JB, Yang GY, Aceves SS, Furuta GT, Rothenberg ME, Koyama T, Dellon ES. Development and validation of web-based tool to predict lamina propria fibrosis in eosinophilic esophagitis. Am J Gastroenterol. 2022 Feb 1;117(2):272-279. doi: 10.14309/ajg.0000000000001587. PMID: 34932022; PMCID: PMC8858426.

Turner KO, Collins MH, Walker MM, Genta RM. Quantification of mucosal eosinophils for the histopathologic diagnosis of eosinophilic gastritis and duodenitis: a primer for practicing pathologists. Am J Surg Pathol. 2022 Apr 1;46(4):557-566. doi: 10.1097/PAS.0000000000001843. PMID: 34913877; PMCID: PMC8923360.

Dunn JLM, Rothenberg ME. 2021 year in review: Spotlight on eosinophils. J Allergy Clin Immunol. 2022 Feb;149(2):517-524. doi: 10.1016/j.jaci.2021.11.012. PMID: 34838883.

Ma C, Jairath V, Feagan BG, Guizzetti L, Zou G, McFarlane SC, Shackelton LM, Collins MH, Hirano I, de Rooij WE, Schaeffer DF, Pai RK, Bredenoord AJ, Dellon ES. Responsiveness of a histologic scoring system compared with peak eosinophil count in eosinophilic esophagitis. Am J Gastroenterol. 2022 Feb 1;117(2):264-271. doi: 10.14309/ajg.0000000000001571. PMID: 34797816.

Shoda T, Wen T, Caldwell JM, Ben-Baruch Morgenstern N, Osswald GA, Rochman M, Mack LE, Felton JM, Abonia JP, Arva NC, Atkins D, Bonis PA, Capocelli KE, Collins MH, Dellon ES, Falk GW, Gonsalves N, Gupta SK, Hirano I, Leung J, Menard-Katcher PA, Mukkada VA, Putnam PE, Rudman Spergel AK, Spergel JM, Wechsler JB, Yang GY, Aceves SS, Furuta GT, Rothenberg ME; Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR) Investigators Group. Loss of endothelial TSPAN12 promotes fibrostenotic eosinophilic esophagitis via endothelial cell-fibroblast crosstalk. Gastroenterology. 2022 Feb;162(2):439-453. doi: 10.1053/j.gastro.2021.10.016. PMID: 34687736; PMCID: PMC8792211.

Dellon ES, Rothenberg ME, Collins MH, Hirano I, Chehade M, Bredenoord AJ, Lucendo AJ, Spergel JM, Aceves S, Sun X, Kosloski MP, Kamal MA, Hamilton JD, Beazley B, McCann E, Patel K, Mannent LP, Laws E, Akinlade B, Amin N, Lim WK, Wipperman MF, Ruddy M, Patel N, Weinreich DR, Yancopoulos GD, Shumel B, Maloney J, Giannelou A, Shabbir A. Dupilumab in adults and adolescents with eosinophilic esophagitis. N Engl J Med. 2022 Dec 22;387(25):2317-2330. doi: 10.1056/NEJMoa2205982. PMID: 36546624.

Janarthanam R, Bolton SM, Wechsler JB. Role of mast cells in eosinophilic esophagitis. Curr Opin Gastroenterol. 2022 Nov 1;38(6):541-548. doi: 10.1097/MOG.0000000000000888. PMID: 36165008.

Larey A, Aknin E, Daniel N, Osswald GA, Caldwell JM, Rochman M, Wasserman T, Collins MH, Arva NC, Yang GY, Rothenberg ME, Savir Y. Harnessing artificial intelligence to infer novel spatial biomarkers for the diagnosis of eosinophilic esophagitis. Front Med (Lausanne). 2022 Oct 21;9:950728. doi: 10.3389/fmed.2022.950728. PMID: 36341260; PMCID: PMC9633847.

Rothenberg ME. Scientific journey to the first FDA-approved drug for eosinophilic esophagitis. J Allergy Clin Immunol. 2022 Dec;150(6):1325-1332. doi: 10.1016/j.jaci.2022.09.027. PMID: 36209816; PMCID: PMC9742179.

Schreiner P, Safroneeva E, Schoepfer A, Greuter T, Biedermann L, Schlag C, Labenz J, Auth MKH, Bredenoord AJ, Chang JW, Bonis PA, Rothenberg ME, Collins MH, Hirano I, Gupta SK, Katzka DA, Dellon ES, Straumann A, Furuta GT, Gonsalves N. Management of eosinophilic esophagitis associated food impaction in Europe and the United States. Dis Esophagus. 2022 Sep 14;35(9):doac003. doi: 10.1093/dote/doac003. PMID: 35088073.

Grisaru-Tal S, Rothenberg ME, Munitz A. Eosinophil-lymphocyte interactions in the tumor microenvironment and cancer immunotherapy. Nat Immunol. 2022 Sep;23(9):1309-1316. doi: 10.1038/s41590-022-01291-2. PMID: 36002647; PMCID: PMC9554620.

Aceves SS, Alexander JA, Baron TH, Bredenoord AJ, Day L, Dellon ES, Falk GW, Furuta GT, Gonsalves N, Hirano I, Konda VJA, Lucendo AJ, Moawad F, Peterson KA, Putnam PE, Richter J, Schoepfer AM, Straumann A, McBride DL, Sharma P, Katzka DA. Endoscopic approach to eosinophilic esophagitis: american society for gastrointestinal endoscopy consensus conference. Gastrointest Endosc. 2022 Oct;96(4):576-592.e1. doi: 10.1016/j.gie.2022.05.013. PMID: 35965102.

Tanzer J, Meng D, Ohsaki A, Caldwell JM, Mingler MK, Rothenberg ME, Oyoshi MK. Laundry detergent promotes allergic skin inflammation and esophageal eosinophilia in mice. PLoS One. 2022 Jun 27;17(6):e0268651. doi: 10.1371/journal.pone.0268651. PMID: 35759448; PMCID: PMC9236249.

Rochman M, Wen T, Kotliar M, Dexheimer PJ, Ben-Baruch Morgenstern N, Caldwell JM, Lim HW, Rothenberg ME. Single-cell RNA-Seq of human esophageal epithelium in homeostasis and allergic inflammation. JCI Insight. 2022 Jun 8;7(11):e159093. doi: 10.1172/jci.insight.159093. PMID: 35472002; PMCID: PMC9208762.

Wright BL, Schwartz JT, Ruffner MA, Furuta GT, Gonsalves N, Dellon ES, Aceves SS. Eosinophilic gastrointestinal diseases make a name for themselves: A new consensus statement with updated nomenclature. J Allergy Clin Immunol. 2022 Aug;150(2):291-293. doi: 10.1016/j.jaci.2022.05.012. PMID: 35649464; PMCID: PMC9378528.

Dellon ES, Khoury P, Muir AB, Liacouras CA, Safroneeva E, Atkins D, Collins MH, Gonsalves N, Falk GW, Spergel JM, Hirano I, Chehade M, Schoepfer AM, Menard-Katcher C, Katzka DA, Bonis PA, Bredenoord AJ, Geng B, Jensen ET, Pesek RD, Feuerstadt P, Gupta SK, Lucendo AJ, Genta RM, Hiremath G, McGowan EC, Moawad FJ, Peterson KA, Rothenberg ME, Straumann A, Furuta GT, Aceves SS. A clinical severity index for eosinophilic esophagitis: development, consensus, and future directions. J Allergy Clin Immunol. 2022 Jul;150(1):33-47. doi: 10.1016/j.jaci.2022.03.015. PMID: 35606166; PMCID: PMC9549868.

Dellon ES, Khoury P, Muir AB, Liacouras CA, Safroneeva E, Atkins D, Collins MH, Gonsalves N, Falk GW, Spergel JM, Hirano I, Chehade M, Schoepfer AM, Menard-Katcher C, Katzka DA, Bonis PA, Bredenoord AJ, Geng B, Jensen ET, Pesek RD, Feuerstadt P, Gupta SK, Lucendo AJ, Genta RM, Hiremath G, McGowan EC, Moawad FJ, Peterson KA, Rothenberg ME, Straumann A, Furuta GT, Aceves SS. A clinical severity index for eosinophilic esophagitis: development, consensus, and future directions. Gastroenterology. 2022 Jul;163(1):59-76. doi: 10.1053/j.gastro.2022.03.025. PMID: 35606197; PMCID: PMC9233087.

Rothenberg ME, Roufosse F, Faguer S, Gleich GJ, Steinfeld J, Yancey SW, Mavropoulou E, Kwon N; HES Mepolizumab Study Group. Mepolizumab reduces hypereosinophilic syndrome flares irrespective of blood eosinophil count and interleukin-5. J Allergy Clin Immunol Pract. 2022 Sep;10(9):2367-2374.e3. doi: 10.1016/j.jaip.2022.04.037. PMID: 35568330.

Arva N, Genta RM, Pletneva M, Walker MM, Yang GY, Collins MH. Eosinophilic gastrointestinal disorders:a new path. Pediatr Dev Pathol. 2022 Sep-Oct;25(5):568-569. doi: 10.1177/10935266221096938. PMID: 35535658.

Dill-McFarland KA, Schwartz JT, Zhao H, Shao B, Fulkerson PC, Altman MC, Gill MA. Eosinophil-mediated suppression and anti-IL-5 enhancement of plasmacytoid dendritic cell interferon responses in asthma. J Allergy Clin Immunol. 2022 Sep;150(3):666-675. doi: 10.1016/j.jaci.2022.03.025. PMID: 35413355.

Robida PA, Rische CH, Morgenstern NB, Janarthanam R, Cao Y, Krier-Burris RA, Korver W, Xu A, Luu T, Schanin J, Leung J, Rothenberg ME, Wechsler JB, Youngblood BA, Bochner BS, O'Sullivan JA. Functional and phenotypic characterization of siglec-6 on human mast cells. Cells. 2022 Mar 28;11(7):1138. doi: 10.3390/cells11071138. PMID: 35406705; PMCID: PMC8997871.

Ben-Baruch Morgenstern N, Ballaban AY, Wen T, Shoda T, Caldwell JM, Kliewer K, Felton JM, Abonia JP, Mukkada VA, Putnam PE, Bolton SM, Dwyer DF, Barrett NA, Rothenberg ME. Single-cell RNA sequencing of mast cells in eosinophilic esophagitis reveals heterogeneity, local proliferation, and activation that persists in remission. J Allergy Clin Immunol. 2022 Jun;149(6):2062-2077. doi: 10.1016/j.jaci.2022.02.025. PMID: 35304158; PMCID: PMC9177790.

Kuang FL, De Melo MS, Makiya M, Kumar S, Brown T, Wetzler L, Ware JM, Khoury P, Collins MH, Quezado M, Pittaluga S, Klion AD. Benralizumab completely depletes gastrointestinal tissue eosinophils and improves symptoms in eosinophilic gastrointestinal disease. J Allergy Clin Immunol Pract. 2022 Jun;10(6):1598-1605.e2. doi: 10.1016/j.jaip.2022.02.037. PMID: 35283330; PMCID: PMC9210216.

Zhang S, Shoda T, Aceves SS, Arva NC, Chehade M, Collins MH, Dellon ES, Falk GW, Gonsalves N, Gupta SK, Hirano I, Khoury P, Leung J, Spergel AKR, Spergel JM, Wechsler JB, Yang GY, Furuta GT, Rothenberg ME; Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR) Investigators Group. Mast cell-pain connection in eosinophilic esophagitis. Allergy. 2022 Jun;77(6):1895-1899. doi: 10.1111/all.15260. PMID: 35175645; PMCID: PMC9167217.

Hirano I, Collins MH, King E, Sun Q, Chehade M, Abonia JP, Bonis PA, Capocelli KE, Dellon ES, Falk GW, Gonsalves N, Gupta SK, Leung J, Katzka D, Menard-Katcher P, Khoury P, Klion A, Mukkada VA, Peterson K, Shoda T, Rudman-Spergel AK, Spergel JA, Yang GY, Rothenberg ME, Aceves SS, Furuta GT; CEGIR investigators. Prospective endoscopic activity assessment for eosinophilic gastritis in a multisite cohort. Am J Gastroenterol. 2022 Mar 1;117(3):413-423. doi: 10.14309/ajg.0000000000001625. PMID: 35080202; PMCID: PMC8897269.

Rothenberg ME. The climate change hypothesis for the allergy epidemic. J Allergy Clin Immunol. 2022 May;149(5):1522-1524. doi: 10.1016/j.jaci.2022.02.006. PMID: 35192868.

Greuter T, Straumann A, Fernandez-Marrero Y, Germic N, Hosseini A, Yousefi S, Simon D, Collins MH, Bussmann C, Chehade M, Dellon ES, Furuta GT, Gonsalves N, Hirano I, Moawad FJ, Biedermann L, Safroneeva E, Schoepfer AM, Simon HU. Characterization of eosinophilic esophagitis variants by clinical, histological, and molecular analyses: A cross-sectional multi-center study. Allergy. 2022 Aug;77(8):2520-2533. doi: 10.1111/all.15233.PMID: 35094416; PMCID: PMC9545458.

Dellon ES, Gonsalves N, Abonia JP, Alexander JA, Arva NC, Atkins D, Attwood SE, Auth MKH, Bailey DD, Biederman L, Blanchard C, Bonis PA, Bose P, Bredenoord AJ, Chang JW, Chehade M, Collins MH, Di Lorenzo C, Dias JA, Dohil R, Dupont C, Falk GW, Ferreira CT, Fox AT, Genta RM, Greuter T, Gupta SK, Hirano I, Hiremath GS, Horsley-Silva JL, Ishihara S, Ishimura N, Jensen ET, Gutiérrez-Junquera C, Katzka DA, Khoury P, Kinoshita Y, Kliewer KL, Koletzko S, Leung J, Liacouras CA, Lucendo AJ, Martin LJ, McGowan EC, Menard-Katcher C, Metz DC, Miller TL, Moawad FJ, Muir AB, Mukkada VA, Murch S, Nhu QM, Nomura I, Nurko S, Ohtsuka Y, Oliva S, Orel R, Papadopoulou A, Patel DA, Pesek RD, Peterson KA, Philpott H, Putnam PE, Richter JE, Rosen R, Ruffner MA, Safroneeva E, Schreiner P, Schoepfer A, Schroeder SR, Shah N, Souza RF, Spechler SJ, Spergel JM, Straumann A, Talley NJ, Thapar N, Vandenplas Y, Venkatesh RD, Vieira MC, von Arnim U, Walker MM, Wechsler JB, Wershil BK, Wright BL, Yamada Y, Yang GY, Zevit N, Rothenberg ME, Furuta GT, Aceves SS. International consensus recommendations for eosinophilic gastrointestinal disease nomenclature. Clin Gastroenterol Hepatol. 2022 Nov;20(11):2474-2484.e3. doi: 10.1016/j.cgh.2022.02.017. PMID: 35181570; PMCID: PMC9378753.

Chen MM, Roufosse F, Wang SA, Verstovsek S, Durrani SR, Rothenberg ME, Pongdee T, Butterfield J, Lax T, Wechsler ME, Stein ML, Ogbogu PU, Kahwash BM, Mathur SK, Simon D, Akuthota P, Holland N, Wetzler L, Ware JM, Guo C, Fay MP, Khoury P, Klion AD, Bochner BS. An international, retrospective study of off-label biologic use in the treatment of hypereosinophilic syndromes. J Allergy Clin Immunol Pract. 2022 May;10(5):1217-1228.e3. doi: 10.1016/j.jaip.2022.02.006. PMID: 35181548; PMCID: PMC9086180.

Hiremath G, Sun L, Correa H, Acra S, Collins MH, Bonis P, Arva NC, Capocelli KE, Falk GW, King E, Gonsalves N, Gupta SK, Hirano I, Mukkada VA, Martin LJ, Putnam PE, Spergel JM, Wechsler JB, Yang GY, Aceves SS, Furuta GT, Rothenberg ME, Koyama T, Dellon ES. Development and validation of web-based tool to predict lamina propria fibrosis in eosinophilic esophagitis. Am J Gastroenterol. 2022 Feb 1;117(2):272-279. doi: 10.14309/ajg.0000000000001587. PMID: 34932022; PMCID: PMC8858426.

Droghini HR, Abonia JP, Collins MH, Milner JD, Lyons JJ, Freeman AF, Mukkada VA, Risma KA, Rothenberg ME, Schwartz JT. Targeted IL-4Rα blockade ameliorates refractory allergic eosinophilic inflammation in a patient with dysregulated TGF-β signaling due to ERBIN deficiency. J Allergy Clin Immunol Pract. 2022 Jul;10(7):1903-1906. doi: 10.1016/j.jaip.2022.01.012. PMID: 35093604; PMCID: PMC9271541.

Shoda T, Collins MH, Rochman M, Wen T, Caldwell JM, Mack LE, Osswald GA, Besse JA, Haberman Y, Aceves SS, Arva NC, Capocelli KE, Chehade M, Davis CM, Dellon ES, Falk GW, Gonsalves N, Gupta SK, Hirano I, Khoury P, Klion A, Menard-Katcher C, Leung J, Mukkada VA, Putnam PE, Spergel JM, Wechsler JB, Yang GY, Furuta GT, Denson LA, Rothenberg ME; Consortium of Eosinophilic Gastrointestinal Diseases Researchers (CEGIR). Evaluating eosinophilic colitis as a unique disease using colonic molecular profiles: a multi-site study. Gastroenterology. 2022 May;162(6):1635-1649. doi: 10.1053/j.gastro.2022.01.022. PMID: 35085569; PMCID: PMC9038694.

Rothenberg ME. Linking the allergy epidemic to climate change. Nat Immunol. 2022 Feb;23(2):149. doi: 10.1038/s41590-021-01119-5. PMID: 35075280.

2021

Gleich GJ, Roufosse F, Chupp G, Faguer S, Walz B, Reiter A, Yancey SW, Bentley JH, Steinfeld J; HES Mepolizumab Study Group. Safety and efficacy of mepolizumab in hypereosinophilic syndrome: an open label extension study. J Allergy Clin Immunol Pract. 2021 Dec;9(12):4431-4440.e1. doi: 10.1016/j.jaip.2021.07.050. PMID: 34389506.

Felton JM, Bouffi C, Schwartz JT, Schollaert KL, Malik A, Vallabh S, Wronowski B, Magier AZ, Merlin L, Barski A, Weirauch MT, Fulkerson PC, Rothenberg ME. Aiolos regulates eosinophil migration into tissues. Mucosal Immunol. 2021 Nov;14(6):1271-1281. doi: 10.1038/s41385-021-00416-4. PMID: 34341502; PMCID: PMC8542574.

Shoda T, Kaufman KM, Wen T, Caldwell JM, Osswald GA, Purnima P, Zimmermann N, Collins MH, Rehn K, Foote H, Eby MD, Zhang W, Ben-Baruch Morgenstern N, Ballaban AY, Habel JE, Kottyan LC, Abonia JP, Mukkada VA, Putnam PE, Martin LJ, Rothenberg ME. Desmoplakin and periplakin genetically and functionally contribute to eosinophilic esophagitis. Nat Commun. 2021 Nov 23;12(1):6795. doi: 10.1038/s41467-021-26939-9. PMID: 34815391; PMCID: PMC8611043.

Grisaru-Tal S, Dulberg S, Beck L, Zhang C, Itan M, Hediyeh-Zadeh S, Caldwell J, Rozenberg P, Dolitzky A, Avlas S, Hazut I, Gordon Y, Shani O, Tsuriel S, Gerlic M, Erez N, Jacquelot N, Belz GT, Rothenberg ME, Davis MJ, Yu H, Geiger T, Madi A, Munitz A. Metastasis-entrained eosinophils enhance lymphocyte-mediated antitumor immunity. Cancer Res. 2021 Nov 1;81(21):5555-5571. doi: 10.1158/0008-5472.CAN-21-0839. PMID: 34429328.

Brusilovsky M, Rochman M, Rochman Y, Caldwell JM, Mack LE, Felton JM, Habel JE, Porollo A, Pasare C, Rothenberg ME. Environmental allergens trigger type 2 inflammation through ripoptosome activation. Nat Immunol. 2021 Oct;22(10):1316-1326. doi: 10.1038/s41590-021-01011-2. PMID: 34531562; PMCID: PMC8487942.

Zimmermann N, Abonia JP, Dreskin SC, Akin C, Bolton S, Happel CS, Geller M, Larenas-Linnemann D, Nanda A, Peterson K, Wasan A, Wechsler J, Zhang S, Bernstein JA. Developing a standardized approach for assessing mast cells and eosinophils on tissue biopsies: a work group report of the AAAAI allergic skin diseases committee. J Allergy Clin Immunol. 2021 Oct;148(4):964-983. doi: 10.1016/j.jaci.2021.06.030. PMID: 34384610.

Friedlander JA, Fleischer DM, Black JO, Levy M, Rothenberg ME, Smith C, Nguyen N, Pan Z, Furuta GT. Unsedated transnasal esophagoscopy with virtual reality distraction enables earlier monitoring of dietary therapy in eosinophilic esophagitis. J Allergy Clin Immunol Pract. 2021 Sep;9(9):3494-3496. doi: 10.1016/j.jaip.2021.06.030. PMID: 34224927; PMCID: PMC8459391.

Ma C, Schoepfer AM, Safroneeva E; COREOS Collaborators; COREOS Collaborators. Development of a core outcome set for therapeutic studies in eosinophilic esophagitis (COREOS): an international multidisciplinary consensus. Gastroenterology. 2021 Sep;161(3):748-755. doi: 10.1053/j.gastro.2021.04.080. PMID: 34022180.

Ma C, Schoepfer AM, Safroneeva E; COREOS Collaborators. A summary of the meetings of the development of a core outcome set for therapeutic studies in eosinophilic esophagitis (COREOS) international multidisciplinary consensus. Gastroenterology. 2021 Sep;161(3):778-784. doi: 10.1053/j.gastro.2021.04.081. PMID: 34051239.

Dunn JLM, Caldwell JM, Ballaban A, Ben-Baruch Morgenstern N, Rochman M, Rothenberg ME. Bidirectional crosstalk between eosinophils and esophageal epithelial cells regulates inflammatory and remodeling processes. Mucosal Immunol. 2021 Sep;14(5):1133-1143. doi: 10.1038/s41385-021-00400-y. PMID: 33972688; PMCID: PMC8380647.

Melethil S, Abonia JP. A gut-wrenching case of hypereosinophilia. J Allergy Clin Immunol Pract. 2021 Sep;9(9):3524-3525. doi: 10.1016/j.jaip.2021.05.039. PMID: 34507713.

Pesek RD, Greuter T, Lopez-Nunez O, Bernieh A, Straumann A, Collins MH. Clinicopathologic correlations in eosinophilic gastrointestinal disorders. J Allergy Clin Immunol Pract. 2021 Sep;9(9):3258-3266. doi: 10.1016/j.jaip.2021.06.002. PMID: 34507707.

Felton JM, Vallabh S, Parameswaran S, Edsall LE, Ernst K, Wronowski B, Malik A, Kotliar M, Weirauch MT, Barski A, Fulkerson PC, Rothenberg ME. Epigenetic analysis of the chromatin landscape identifies a repertoire of murine eosinophil-specific PU.1-bound enhancers. J Immunol. 2021 Aug 15;207(4):1044-1054. doi: 10.4049/jimmunol.2000207. PMID: 34330753; PMCID: PMC8355082.

Morgenstern NB, Rochman M, Rothenberg ME. Zooming in on T cell clones: are we heading to personalized treatment of allergy? Sci Immunol. 2021 Aug 13;6(62):eabj1366. doi: 10.1126/sciimmunol.abj1366. PMID: 34389614.

Dellon ES, Collins MH, Katzka DA, Mukkada VA, Falk GW, Morey R, Goodwin B, Eisner JD, Lan L, Desai NK, Williams J, Hirano I; ORBIT2/SHP621-302 Investigators. Long-term treatment of eosinophilic esophagitis with budesonide oral suspension. Clin Gastroenterol Hepatol. 2021 Jun 26:S1542-3565(21)00684-4. doi: 10.1016/j.cgh.2021.06.020. PMID: 34182150.

Czyzewski T, Daniel N, Rochman M, Caldwell JM, Osswald GA, Collins MH, Rothenberg ME, Savir Y. Machine learning approach for biopsy-based identification of eosinophilic esophagitis reveals importance of global features. IEEE Open J Eng Med Biol. 2021;2:218-223. doi: 10.1109/ojemb.2021.3089552. PMID: 34505063; PMCID: PMC8425173.

Sabet C, Klion AD, Bailey D, Jensen E, Chehade M, Abonia JP, Rothenberg ME, Furuta GT, Muir AB; CEGIR Investigator Group. Do rural health disparities affect prevalence data in pediatric eosinophilic esophagitis? J Allergy Clin Immunol Pract. 2021 Jun;9(6):2549-2551. doi: 10.1016/j.jaip.2021.03.027. PMID: 34112494.

Chiang AWT, Duong LD, Shoda T, Nhu QM, Ruffner M, Hara T, Aaron B, Joplin E, Manresa MC, Abonia JP, Dellon ES, Hirano I, Gonsalves N, Gupta SK, Furuta GT, Rothenberg ME, Lewis NE, Muir AB, Aceves SS; CEGIR Investigator Group. Type 2 immunity and age modify gene expression of coronavirus-induced disease 2019 receptors in eosinophilic gastrointestinal disorders. J Pediatr Gastroenterol Nutr. 2021 May 1;72(5):718-722. doi: 10.1097/MPG.0000000000003032. PMID: 33394891; PMCID: PMC8048378.

Mersha TB, Afanador Y, Johansson E, Proper SP, Bernstein JA, Rothenberg ME, Khurana Hershey GK. Resolving clinical phenotypes into endotypes in allergy: molecular and omics approaches. Clin Rev Allergy Immunol. 2021 Apr;60(2):200-219. doi: 10.1007/s12016-020-08787-5. PMID: 32378146; PMCID: PMC8209667.

Jacobsen EA, Jackson DJ, Heffler E, Mathur SK, Bredenoord AJ, Pavord ID, Akuthota P, Roufosse F, Rothenberg ME. Eosinophil knockout humans: uncovering the role of eosinophils through eosinophil-directed biological therapies. Annu Rev Immunol. 2021 Apr 26;39:719-757. doi: 10.1146/annurev-immunol-093019-125918. PMID: 33646859; PMCID: PMC8317994.

Dellon ES, Shaheen O, Koutlas NT, Chang AO, Martin LJ, Rothenberg ME, Jensen ET. Early life factors are associated with risk for eosinophilic esophagitis diagnosed in adulthood. Dis Esophagus. 2021 Feb 10;34(2):doaa074. doi: 10.1093/dote/doaa074. PMID: 32766724; PMCID: PMC7874052.

Hou G, Harley ITW, Lu X, Zhou T, Xu N, Yao C, Qin Y, Ouyang Y, Ma J, Zhu X, Yu X, Xu H, Dai D, Ding H, Yin Z, Ye Z, Deng J, Zhou M, Tang Y, Namjou B, Guo Y, Weirauch MT, Kottyan LC, Harley JB, Shen N. SLE non-coding genetic risk variant determines the epigenetic dysfunction of an immune cell specific enhancer that controls disease-critical microRNA expression. Nat Commun. 2021 Jan 8;12(1):135. doi: 10.1038/s41467-020-20460-1. PMID: 33420081; PMCID: PMC7794586.

O'Shea KM, Rochman M, Shoda T, Zimmermann N, Caldwell J, Rothenberg ME. Eosinophilic esophagitis with extremely high esophageal eosinophil counts. J Allergy Clin Immunol. 2021 Jan;147(1):409-412.e5. doi: 10.1016/j.jaci.2020.05.045. PMID: 32526311; PMCID: PMC7722099.

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