Cincinnati Center for Eosinophilic Disorders

  • Ongoing Research: A Critical Need

    Researchers at the Cincinnati Center for Eosinophilic Disorders are worldwide leaders in the field. Our research involves basic, clinical and translational studies to determine the reason for the current epidemic of eosinophilic disorders and to develop a cure for the disease.

    Because of our growing knowledge and ever improving technology, we have an unprecedented ability to make strides in our understanding of these diseases. We are currently studying compounds that might block eosinophil production, as we strive to develop the next and best treatment for eosinophil-associated medical disorders. Read our Research Summary to see what we have learned about these diseases so far and what we still need to learn.

    Research on these disorders is undersupported by current grant agencies. A quest for a cure is only limited by this shortage of funds. Your gift can help ensure that cures will be developed in the future. To find out how you can help, contact cced@cchmc.org.

    Eosinophilic Gastrointestinal Disorder (EGID) Twins Needed!

    Eosinophilic disorders occur when eosinophils, a type of white blood cell, are found in above-normal amounts in various parts of the body. When the body wants to attack a substance, such as an allergy-triggering food or airborne allergen, eosinophils respond by moving into the area and releasing a variety of toxins. However, when the body produces too many eosinophils, they can cause chronic inflammation, resulting in tissue damage.

    Eosinophilic Gastrointestinal Disorders are diagnosed according to where the elevated levels of eosinophils are found:

    • Eosinophilic esophagitis (esophagus)
    • Eosinophilic gastritis (stomach)
    • Eosinophilic enteritis (small intestine)
    • Eosinophilic colitis (large intestine)

    EGIDs can occur in multiple members of families. A  study published in Clinical Gastroenterology and Hepatology reported that there was a familial pattern of inheritance of EoE (Eosinophilic Esophagitis) in 26 families. Prior studies have shown a sibling risk ratio of over 60 fold, meaning that siblings have a great risk of co-developing EoE if one sibling already has EoE. Based on this finding, EoE should be considered in symptomatic family members of patients who have EoE. Further, this serves as rationale to conduct further research on siblings and twins with EGIDs.

    We are currently focusing on a genetic analysis of siblings especially, twins and triplets. For more information, email EEtwins@cchmc.org

    Eosinophils May Play Role in Asthma Symptoms

    Cincinnati scientists have found further evidence that certain defensive white blood cells in the body, eosinophils, cause or play a major role in asthma symptoms. These findings could help identify a new treatment target to help asthma sufferers. Read the full story about the findings from this research study on eosinophils. You can view the full story with photos (on page 4) from the American Health Center Findings in portable document format (.pdf).

    Clinical Studies at the CCED

    We are actively conducting research to help understand and improve outcomes for patients with eosinophilic disorders. For more information on our ongoing trials, open the studies in portable document format (PDF) below:

    Clinical Trials

    For online information about clinical trials, visit ClinicalTrials.gov, a service of the National Institutes of Health, is a user-friendly site that allows patients and families to:

    • Search for clinical trails by condition, funding organizations (both federally funded and privately supported), location and / or names of researchers
    • Obtain easy-to-read, detailed information on clinical trial basics, participation in clinical trails, clinical trial terms and links to additional information

    For research inquiries, contact our Clinical Research Coordinator Tommie Grotjan: tommie.grotjan@cchmc.org.

 
  • Twins and Genetics Related to Eosinophilic Esophagitis


    Genetic experts at the Cincinnati Center for Eosinophilic Disorders (CCED) at Cincinnati Children's discuss current research related to twins and eosinophilic esophagitis (EE or EoE).
  • The International Gastrointestinal Eosinophil Researchers (TIGER).

    Click image to enlarge and see full caption.

    The International Gastrointestinal Eosinophil Researchers (TIGER)

    The International Gastrointestinal Eosinophil Researchers (TIGER).

    The International Gastrointestinal Eosinophil Researchers (TIGER)

    TIGER represents a consortium of world experts focusing on the role of eosinophils in gastrointestinal diseases. Consortium members with pediatric and adult expertise share new diagnostic criteria, build interest among young investigators, develop a research agenda for cooperative multi-center studies, and offer therapeutic strategies for the thousands of children and adults who suffer from this emerging disease.

  • The Registry for Eosinophilic Gastrointestinal Disorders (REGID)

    Eosinophilis.

    REGID is a collaboration of medical centers, professionals, families and individuals whose mission is to improve the knowledge, research and outcomes for people living with eosinophilic gastrointestinal disorders.

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