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Department Head

Marc E. Rothenberg, MD, PhD
Director, Allergy and Immunology

513-803-0257

marc.rothenberg@cchmc.org

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Marc E. Rothenberg, MD, PhD

Director, Allergy and Immunology

Director, Cincinnati Center for Eosinophilic Disorders

Program Director, CHRCDA (K12)

Professor, UC Department of Pediatrics

Phone: 513-803-0257

Fax: 513-636-3310

Email: marc.rothenberg@cchmc.org

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Specialties

Clinical Interests

Eosinophilia; eosinophilic disorders; asthma; allergy; food allergy

Research Interests

Eosinophils; chemokines

Visit the Rothenberg Lab.

Biography

Marc E. Rothenberg, MD, PhD, is the Director of the Division of Allergy and Immunology at Cincinnati Children's Hospital Medical Center, and a tenured Professor of Pediatrics at Cincinnati Children’s and the University of Cincinnati College of Medicine. He graduated summa cum laude with Highest Honors in Chemistry and Biochemistry from Brandeis University. He then matriculated at Harvard Medical School in the combined MD / PhD program. His PhD under the mentorship of Dr. Frank Austen included seminal studies on eosinophil hematopoiesis, as he developed the first culture system for human eosinophils.

After completing a two-year residency in pediatrics at Children’s Hospital in Boston, Dr. Rothenberg did a combined fellowship in allergy / immunology and hematology at Children’s Hospital in Boston. During this fellowship program, Dr. Rothenberg did post-doctorate training in the genetics laboratory of Dr. Philip Leder at Harvard Medical School, where he cloned the eotaxin chemokine. After being on faculty of Harvard Medical School for one year, he came to the University of Cincinnati and Cincinnati Children's, one of the largest pediatric medical and research centers in the United States. He is actively involved in managing a research program focused on understanding the molecular mechanisms of allergic disorders. At Cincinnati Children’s, he has helped build a top program in pediatric research, and his division is a leader in pediatric allergy and immunology. In addition, he sees patients suffering from allergic and immunological diseases from around the world as part of the Cincinnati Center for Eosinophilic Disorders that he directs.

Dr. Rothenberg’s awards include the Pharmacia Allergy Research Foundation Award for the best young investigator in the allergy field; the Young Investigator Award and the Scholar in Allergy Award from the American Academy of Allergy, Asthma, and Immunology; the Ohio Governor’s Recognition Award; the 2007 E Mead Johnson Award from the Society of Pediatric Research; and an NIH MERIT Award in 2010 from the NIAID. He is an elected member of the American Society of Clinical Investigation, Society for Pediatric Research, and a Diplomate of the American Academy of Allergy, Asthma and Immunology.

Among his extensive publications of over 220 articles on molecular mechanisms of allergic responses, Dr. Rothenberg edited a book entitled, “Chemokines in Allergic Disease”. He has served on various review panels for journals and grant agencies including the National Institutes of Health, where he served on the Advisory Council of the NIAID, Burroughs Trust, and the Medical Research Council of the UK. His research has been supported by numerous sources including the National Institutes of Health, the USA Department of Defense, Human Frontier Science Program Organization, the Burroughs Wellcome Fund, the Dana Foundation, and the Food Allergy and Anaphylaxis Network.

Visit the Rothenberg Lab website

Education and Training

MD, PhD: Harvard Medical School, Cambridge, MA, 1990.

Residency: Pediatrics, Children's Hospital, Boston, MA, 1991-1992.

Fellowship: Immunology / Allergy, Children's Hospital, Boston, MA, 1992-1994; Hematology / Oncology, Children's Hospital and Dana Farber Cancer Institute, Boston, MA, 1992-1995.

Certification: National Board of Medical Examiners, 1991; Board of Registration in Medicine, MA, 1992; American Board of Pediatrics, 1995, 2001, 2008; Ohio State Medical Board, 1997; American Board of Allergy and Immunology, 1997, 2006.

Publications

Franciosi JP, Hommel KA, Debrosse CW, Greenberg AB, Greenler AJ, Abonia JP, Rothenberg ME, Varni JW. Quality of life in paediatric eosinophilic oesophagitis: what is important to patients? Child Care Health Dev. 2011.

Sherrill JD, Rothenberg ME. Genetic dissection of eosinophilic esophagitis provides insight into disease pathogenesis and treatment strategies. J Allergy Clin Immunol. 2011.

Liacouras CA, Furuta GT, Hirano I, Atkins D, Attwood SE, Bonis PA, Burks AW, Chehade M, Collins MH, Dellon ES, Dohil R, Falk GW, Gonsalves N, Gupta SK, Katzka DA, Lucendo AJ, Markowitz JE, Noel RJ, Odze RD, Putnam PE, Richter JE, Romero Y, Ruchelli E, Sampson HA, Schoepfer A, Shaheen NJ, Sicherer SH, Spechler S, Spergel JM, Straumann A, Wershil BK, Rothenberg ME, Aceves SS. Eosinophilic esophagitis: Updated consensus recommendations for children and adults. J Allergy Clin Immunol. 2011.

Baye TM, Butsch Kovacic M, Biagini Myers JM, Martin LJ, Lindsey M, Patterson TL, He H, Ericksen MB, Gupta J, Tsoras AM, Lindsley A, Rothenberg ME, Wills-Karp M, Eissa NT, Borish L, Khurana Hershey GK. Differences in Candidate Gene Association between European Ancestry and African American Asthmatic Children. PLoS One. 2011 Feb 28;6(2):e16522.

Blanchard C, Stucke EM, Rodriguez-Jimenez B, Burwinkel K, Collins MH, Ahrens A, Alexander ES, Butz BK, Jameson SC, Kaul A, Franciosi JP, Kushner JP, Putnam PE, Abonia JP, Rothenberg ME. A striking local esophageal cytokine expression profile in eosinophilic esophagitis. J Allergy Clin Immunol. 2011 Jan;127(1):208-17, 217.e1-7.

Zhu H, Perkins C, Mingler MK, Finkelman FD, Rothenberg ME. The role of neuropeptide S and neuropeptide S receptor 1 in regulation of respiratory function in mice. Peptides. 2011 Apr;32(4):818-25.

Sivaprasad U, Warrier MR, Gibson AM, Chen W, Tabata Y, Bass SA, Rothenberg ME, Khurana Hershey GK. IL-13Rα2 has a protective role in a mouse model of cutaneous inflammation. J Immunol. 2010 Dec 1;185(11):6802-8.

Miles MV, Putnam PE, Miles L, Tang PH, DeGrauw AJ, Wong BL, Horn PS, Foote HL, Rothenberg ME. Acquired coenzyme Q10 deficiency in children with recurrent food intolerance and allergies. Mitochondrion. 2011 Jan;11(1):127-35.

Lacy P, Willetts L, Kim JD, Lo AN, Lam B, Maclean EI, Moqbel R, Rothenberg ME, Zimmermann N. Agonist Activation of F-Actin-Mediated Eosinophil Shape Change and Mediator Release Is Dependent on Rac2. Int Arch Allergy Immunol. 2011;156(2):137-147.

Grants

NICHHD Pediatric Center for Gene Expression and Developmental Sciences. Program Director. National Institutes of Health. 2007-2011. K12 HD028827.

IL-13 and Eosinophilic Esophagitis. Principal Investigator. National Institutes of Health. 2007-2012. R01 DK076893.

Genetics of Eosinophilic Esophagitis. Principal Investigator. Department of Defense. 2010-2012. DOD W81XWH1010167.

Resistin-like Molecules in the Lung. Co-Principal Investigator. US-Israel Binational Science Foundation. 2010-2012. #2009222.

IL-13 Associated Eosinophil Lung Responses. Principal Investigator. National Institutes of Health. 2009-2014. R01 AI083450.

Regulation of Gastrointestinal Eosinophils. Principal Investigator. National Institutes of Health. 2009-2014. R37 AI045898.

Physicians

J. Pablo Abonia, MD

513-636-9463

pablo.abonia@cchmc.org

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J. Pablo Abonia, MD

Assistant Professor, UC Department of Pediatrics

Phone: 513-636-9463

Fax: 513-636-3310

Email: pablo.abonia@cchmc.org

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Specialties

Immunodeficiency; mast cell progenitor homing / recruitment and its involvement in allergic disorders

Biography

J. Pablo Abonia, MD, provides the bulk of the clinical allergy care for patients with eosinophilic disease. He is currently involved in a multicenter clinical research trial of anti-IL5 (reslizumab) for patients with eosinophilic esophagitis. His research focuses on mining the research databanks (patient characteristics, tissue samples, RNA, and DNA) to elucidate the mechanisms, diagnosis and treatment of eosinophilic esophagitis. He is particularly interested in the role of mast cells in eosinophilic esophagitis.

Education and Training

MD: University of Buffalo, Buffalo, NY, 1997.

Residency: Pediatrics, Children's Hospital of Buffalo, Buffalo, NY, 2000.

Certification: American Board of Pediatrics, 2001; American Board of Allergy and Immunology, 2003.

Publications

View PubMed Publications

Abonia JP, Putnam PE. Mepolizumab in eosinophilic disorders. Expert Rev Clin Immunol. 2011 Jul;7(4):411-7.

Debrosse CW, Franciosi JP, King EC, Buckmeier Butz BK, Greenberg AB, Collins MH, Abonia JP, Assa'ad A, Putnam PE, Rothenberg ME. Long-term outcomes in pediatric-onset esophageal eosinophilia. J Allergy Clin Immunol. 2011 Jul;128(1):132-8.

Franciosi JP, Hommel KA, Debrosse CW, Greenberg AB, Greenler AJ, Abonia JP, Rothenberg ME, Varni JW. Quality of life in paediatric eosinophilic oesophagitis: what is important to patients?Child Care Health Dev. 2011 Jun 15. Epub ahead of print.

Abonia JP, Castells M. Drug allergy in pediatric patients. Pediatr Ann. 2011 Apr;40(4):200-4.

Blanchard C, Stucke EM, Rodriguez-Jimenez B, Burwinkel K, Collins MH, Ahrens A, Alexander ES, Butz BK, Jameson SC, Kaul A, Franciosi JP, Kushner JP, Putnam PE, Abonia JP, Rothenberg ME. A striking local esophageal cytokine expression profile in eosinophilic esophagitis. J Allergy Clin Immunol. 2011 Jan;127(1):208-17, 217.e1-7.

Sherrill JD, Gao PS, Stucke EM, Blanchard C, Collins MH, Putnam PE, Franciosi JP, Kushner JP, Abonia JP, Assa'ad AH, Kovacic MB, Biagini Myers JM, Bochner BS, He H, Hershey GK, Martin LJ, Rothenberg ME. Variants of thymic stromal lymphopoietin and its receptor associate with eosinophilic esophagitis. J Allergy Clin Immunol. 2010 Jul;126(1):160-5.e3.

DeBrosse CW, Collins MH, Buckmeier Butz BK, Allen CL, King EC, Assa'ad AH, Abonia JP, Putnam PE, Rothenberg ME, Franciosi JP. Identification, epidemiology, and chronicity of pediatric esophageal eosinophilia, 1982-1999. J Allergy Clin Immunol. 2010 Jul;126(1):112-9.

Abonia JP, Blanchard C, Butz BB, Rainey HF, Collins MH, Stringer K, Putnam PE, Rothenberg ME. Involvement of mast cells in eosinophilic esophagitis. J Allergy Clin Immunol. 2010 Jul;126(1):140-9.

Rayapudi M, Mavi P, Zhu X, Pandey AK, Abonia JP, Rothenberg ME, Mishra A. Indoor insect allergens are potent inducers of experimental eosinophilic esophagitis in mice. J Leukoc Biol. 2010 Aug;88(2):337-46.

Rothenberg ME, Spergel JM, Sherrill JD, Annaiah K, Martin LJ, Cianferoni A, Gober L, Kim C, Glessner J, Frackelton E, Thomas K, Blanchard C, Liacouras C, Verma R, Aceves S, Collins MH, Brown-Whitehorn T, Putnam PE, Franciosi JP, Chiavacci RM, Grant SF, Abonia JP, Sleiman PM, Hakonarson H. Common variants at 5q22 associate with pediatric eosinophilic esophagitis. Nat Genet. 2010 Apr;42(4):289-91.

Amal H. Assa'ad, MD
Director, Allergy and Immunology Fellowship Program

513-636-6771

amal.assa'ad@cchmc.org

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Amal H. Assa'ad, MD

Director, Allergy and Immunology Fellowship Program

Director, Clinical Services

Professor, UC Department of Pediatrics

Phone: 513-636-6771

Fax: 513-636-4615

Email: amal.assa'ad@cchmc.org

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Specialties

Food allergy; asthma; vaccine allergy; immunodeficiencies

Education and Training

MBBCh (MD): Ain Shams University, Cairo, Egypt 1978.

MS: Ain Shams University, Cairo, Egypt, 1982.

Residency: Internal Medicine/Pediatrics, Michigan State University, Hurley Medical Center, Flint, Mich.; Internal Medicine/Pediatrics, Wright State University, Dayton, Ohio, 1990-1992.

Fellowship: Allergy/Clinical Immunology, University of Texas Health Science Center, San Antonio, Texas, 1986-1987; Allergy/Clinical Immunology, Children's Hospital Medical Center, Cincinnati, Ohio, 1992-1995.

Certification: American Board of Internal Medicine, 1992; American Board of Pediatrics, 1992; American Board of Allergy and Immunology, 1995.

Publications

View PubMed Publications

DeBrosse CW, Collins MH, Buckmeier Butz BK, Allen CL, King EC, Assa'ad AH, Abonia JP, Putnam PE, Rothenberg ME, Franciosi JP. Identification, epidemiology, and chronicity of pediatric esophageal eosinophilia, 1982-1999. J Allergy Clin Immunol. 2010 Jul;126(1):112-9.

Assa'ad A. Eosinophilic gastrointestinal disorders. Allergy Asthma Proc. 2009 Jan-Feb;30(1):17-22.

Assa'ad A. Gastrointestinal eosinophil-mediated disorders and their treatment. Curr Allergy Asthma Rep. 2009 Jan;9(1):26-9.

Collins MH, Blanchard C, Abonia JP, Kirby C, Akers R, Wang N, Putnam PE, Jameson SC, Assa'ad AH, Konikoff MR, Stringer KF, Rothenberg ME. Clinical, pathologic, and molecular characterization of familial eosinophilic esophagitis compared with sporadic cases.Clin Gastroenterol Hepatol. 2008 Jun;6(6):621-9.

Stein ML, Villanueva JM, Buckmeier BK, Yamada Y, Filipovich AH, Assa'ad AH, Rothenberg ME. Anti-IL-5 (mepolizumab) therapy reduces eosinophil activation ex vivo and increases IL-5 and IL-5 receptor levels. J Allergy Clin Immunol. 2008 Jun;121(6):1473-83, 1483.e1-4.

Rothenberg ME, Klion AD, Roufosse FE, Kahn JE, Weller PF, Simon HU, Schwartz LB, Rosenwasser LJ, Ring J, Griffin EF, Haig AE, Frewer PI, Parkin JM, Gleich GJ; Mepolizumab HES Study Group. Treatment of patients with the hypereosinophilic syndrome with mepolizumab. N Engl J Med. 2008 Mar 20;358(12):1215-28.

Gupta J, Grube E, Ericksen MB, Stevenson MD, Lucky AW, Sheth AP, Assa'ad AH, Khurana Hershey GK. Intrinsically defective skin barrier function in children with atopic dermatitis correlates with disease severity. J Allergy Clin Immunol. 2008 Mar;121(3):725-730.e2.

Assa'ad A. Eosinophilic esophagitis: association with allergic disorders.Gastrointest Endosc Clin N Am. 2008 Jan;18(1):119-32; x.

Bullock JZ, Villanueva JM, Blanchard C, Filipovich AH, Putnam PE, Collins MH, Risma KA, Akers RM, Kirby CL, Buckmeier BK, Assa'ad AH, Hogan SP, Rothenberg ME. Interplay of adaptive th2 immunity with eotaxin-3/c-C chemokine receptor 3 in eosinophilic esophagitis. J Pediatr Gastroenterol Nutr. 2007 Jul;45(1):22-31.

Margaret Collins is a Professor of Pathology at Cincinnati Children's.

Margaret H. Collins, MD

513-636-4261

margaret.collins@cchmc.org

High Res

Margaret H. Collins, MD

Professor, Division of Pediatric Pathology

Phone: 513-636-4261

Fax: 513-636-3924

Email: margaret.collins@cchmc.org

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Specialties

Clinical Interests

Dr. Collins is a pediatric pathologist specializing in pediatric gastrointestinal pathology, especially eosinophilic gastrointestinal diseases. She has provided biopsy analyses, including primary study endpoints, for several clinical trials testing novel therapies to treat eosinophilic esophagitis in children. She also performs clinical research in other disorders of bowel immunity, and bowel motility disorders.

Biography

In 2011, Dr. Collins was named one of the Top Doctors in Pathology by U.S. News & World Report.

Education and Training

BS: Fordham University, N.Y., 1972.

MD: Georgetown University, Washington, D.C., 1977.

Residency: Pathology, New York Hospital, N.Y., 1977-80; Pathology, Columbia-Presbyterian Medical Center, N.Y., 1980-83.

Fellowship: Research, New York Lung Association, Columbia-Presbyterian Medical Center, N.Y., 1983-85; Research, American Lung Association, Columbia-Presbyterian Medical Center, N.Y., 1985-87.

Certification: Pathology, 1981; Pediatric Pathology, 1991.

Publications

View PubMed Publications

Nikolaidis NM, Kulkarni RM, Gray JK, Collins MH, Waltz SE. Ron receptor deficient alveolar myeloid cells exacerbate LPS-induced acute lung injury in the murine lung. Innate Immun. 2010 Nov 18.

Sherrill JD, Gao PS, Stucke EM, Blanchard C, Collins MH, Putnam PE, Franciosi JP, Kushner JP, Abonia JP, Assa'ad AH, Kovacic MB, Biagini Myers JM, Bochner BS, He H, Hershey GK, Martin LJ, Rothenberg ME. Variants of thymic stromal lymphopoietin and its receptor associate with eosinophilic esophagitis. J Allergy Clin Immunol. 2010 Jul;126(1):160-5.e3.

DeBrosse CW, Collins MH, Buckmeier Butz BK, Allen CL, King EC, Assa'ad AH, Abonia JP, Putnam PE, Rothenberg ME, Franciosi JP.Identification, epidemiology, and chronicity of pediatric esophageal eosinophilia, 1982-1999. J Allergy Clin Immunol. 2010 Jul;126(1):112-9.

Abonia JP, Blanchard C, Butz BB, Rainey HF, Collins MH, Stringer K, Putnam PE, Rothenberg ME.Involvement of mast cells in eosinophilic esophagitis. J Allergy Clin Immunol. 2010 Jul;126(1):140-9.

Caldwell JM, Blanchard C, Collins MH, Putnam PE, Kaul A, Aceves SS, Bouska CA, Rothenberg ME.Glucocorticoid-regulated genes in eosinophilic esophagitis: a role for FKBP51. J Allergy Clin Immunol. 2010 Apr;125(4):879-888.e8.

Rothenberg ME, Spergel JM, Sherrill JD, Annaiah K, Martin LJ, Cianferoni A, Gober L, Kim C, Glessner J, Frackelton E, Thomas K, Blanchard C, Liacouras C, Verma R, Aceves S, Collins MH, Brown-Whitehorn T, Putnam PE, Franciosi JP, Chiavacci RM, Grant SF, Abonia JP, Sleiman PM, Hakonarson H. Common variants at 5q22 associate with pediatric eosinophilic esophagitis. Nat Genet. 2010 Apr;42(4):289-91.

Blanchard C, Stucke EM, Burwinkel K, Caldwell JM, Collins MH, Ahrens A, Buckmeier BK, Jameson SC, Greenberg A, Kaul A, Franciosi JP, Kushner JP, Martin LJ, Putnam PE, Abonia JP, Wells SI, Rothenberg ME. Coordinate interaction between IL-13 and epithelial differentiation cluster genes in eosinophilic esophagitis. J Immunol. 2010 Apr 1;184(7):4033-41.

Miller SJ, Lan ZD, Hardiman A, Wu J, Kordich JJ, Patmore DM, Hegde RS, Cripe TP, Cancelas JA, Collins MH, Ratner N. Inhibition of Eyes Absent Homolog 4 expression induces malignant peripheral nerve sheath tumor necrosis. Oncogene. 2010 Jan 21;29(3):368-79.

Vicario M, Blanchard C, Stringer KF, Collins MH, Mingler MK, Ahrens A, Putnam PE, Abonia JP, Santos J, Rothenberg ME. Local B cells and IgE production in the oesophageal mucosa in eosinophilic oesophagitis. Gut. 2010 Jan;59(1):12-20.

Prosperi JR, Becher KR, Willson TA, Collins MH, Witte DP, Goss KH. The APC tumor suppressor is required for epithelial integrity in the mouse mammary gland. J Cell Physiol. 2009 Aug;220(2):319-31.

Alessandro de Alarcon, MD, MPH
Director, Center for Pediatric Voice Disorders at Cincinnati Children’s

513-636-4355

alessandro.dealarcon@cchmc.org

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Alessandro de Alarcon, MD, MPH

Director, Center for Pediatric Voice Disorders at Cincinnati Children’s

Assistant Professor, Division of Pediatric Surgery

Phone: 513-636-4355

Fax: 513-636-8133

Email: alessandro.dealarcon@cchmc.org

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Specialties

Airway reconstruction; pediatric voice disorders; pediatric sinonasal conditions; eosinophilic esophagitis; health outcomes research; quality improvement in health care

Education and Training

MD: VCU School of Medicine.

Residency: University of Virginia Health Systems.

Fellowship: Cincinnati Children's Hospital Medical Center.

Certification: American Board of Otoalryngology, 2007.

Publications

View PubMed Publications

Cortina S, McGraw K, Dealarcon A, Ahrens A, Rothenberg ME, Drotar D. Psychological Functioning of Children and Adolescents With Eosinophil-Associated Gastrointestinal Disorders. Child Health Care. 2010 Oct;39(4):266-278.

Kelchner LN, Brehm SB, Weinrich B, Middendorf J, deAlarcon A, Levin L, Elluru R. Perceptual evaluation of severe pediatric voice disorders: rater reliability using the consensus auditory perceptual evaluation of voice. J Voice. 2010 Jul;24(4):441-9.

Richter GT, Rutter MJ, deAlarcon A, Orvidas LJ, Thompson DM. Late-onset laryngomalacia: a variant of disease. Arch Otolaryngol Head Neck Surg. 2008 Jan;134(1):75-80.

de Alarcón A, Kesser BW, Jahrsdoerfer RA. Congenital Absence of the Oval Window: Diagnosis, Surgery, and Audiometric Outcomes. Otology & Neurotology. 2008;29(1):23-8.

Becker SS, de Alarcón A, Bomeli SR, Han JK, Gross CW. Risk Factors for Recurrent Sinus Surgery in Cystic Fibrosis: Review of a Decade of Experience. American Journal of Rhinology. 2007;21(4):478-82.

de Alarcón A, Choo DI. Controversies in Aural Atresia Repair. Current Opinion in Otolaryngology & Head and Neck Surgery. 2007;15(5):310-314.

de Alarcón A, Steinke JW, Caughey R, Barekzi E, Hise K, Gross CW, Han JK, Borish L. Expression of leukotriene C4 synthase and plasminogen activator inhibitor 1 gene promoter polymorphisms in sinusitis. American Journal of Rhinology. 2006;20(5): 545-549.

Simon P. Hogan, PhD
Director of Admissions, Immunobiology Graduate Program

513-636-6620

simon.hogan@cchmc.org

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Simon P. Hogan, PhD

Director of Admissions, Immunobiology Graduate Program

Associate Professor, UC Department of Pediatrics

Phone: 513-636-6620

Fax: 513-636-3310

Email: simon.hogan@cchmc.org

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Specialties

Allergies; food allergies; eosinophil biology; gastrointestinal inflammation

Visit the Hogan Lab.

Education and Training

BSC: Australian National University, Canberra, Australia, 1998.

PhD: John Curtin School of Medical Research, Australian National University, Canberra, Australia, 1998.

Publications

View PubMed Publications

Munitz A, Cole ET, Beichler A, Groschwitz K, Ahrens R, Steinbrecher K, Willson T, Han X, Denson L, Rothenberg ME, Hogan SP. Paired immunoglobulin-like receptor B (PIR-B) negatively regulates macrophage activation in experimental colitis. Gastroenterology. 2010 Aug;139(2):530-41.

Osterfeld H, Ahrens R, Strait R, Finkelman FD, Renauld JC, Hogan SP. Differential roles for the IL-9/IL-9 receptor alpha-chain pathway in systemic and oral antigen-induced anaphylaxis. J Allergy Clin Immunol. 2010 Feb;125(2):469-476.e2.

Finkelman FD, Hogan SP, Hershey GK, Rothenberg ME, Wills-Karp M. Importance of cytokines in murine allergic airway disease and human asthma. J Immunol. 2010 Feb 15;184(4):1663-74. Review.

Groschwitz KR, Ahrens R, Osterfeld H, Gurish MF, Han X, Abrink M, Finkelman FD, Pejler G, Hogan SP. Mast cells regulate homeostatic intestinal epithelial migration and barrier function by a chymase/Mcpt4-dependent mechanism. Proc Natl Acad Sci U S A. 2009 Dec 29;106(52):22381-6.

Herbert DR, Yang JQ, Hogan SP, Groschwitz K, Khodoun M, Munitz A, Orekov T, Perkins C, Wang Q, Brombacher F, Urban JF Jr, Rothenberg ME, Finkelman FD. Intestinal epithelial cell secretion of RELM-beta protects against gastrointestinal worm infection. J Exp Med. 2009 Dec 21;206(13):2947-57.

Groschwitz KR, Hogan SP. Intestinal barrier function: molecular regulation and disease pathogenesis. J Allergy Clin Immunol. 2009 Jul;124(1):3-20; quiz 21-2. Review.

Munitz A, Seidu L, Cole ET, Ahrens R, Hogan SP, Rothenberg ME. Resistin-like molecule alpha decreases glucose tolerance during intestinal inflammation. J Immunol. 2009 Feb 15;182(4):2357-63.

Hogan SP. Functional role of eosinophils in gastrointestinal inflammation. Immunol AllergyClin North Am. 2009 Feb;29(1):129-40, xi. Review.

Munitz A, Waddell A, Seidu L, Cole ET, Ahrens R, Hogan SP, Rothenberg ME. Resistin-like molecule alpha enhances myeloid cell activation and promotes colitis. J Allergy Clin Immunol. 2008 Dec;122(6):1200-1207.e1.

Ahrens R, Waddell A, Seidu L, Blanchard C, Carey R, Forbes E, Lampinen M, Wilson T, Cohen E, Stringer K, Ballard E, Munitz A, Xu H, Lee N, Lee JJ, Rothenberg ME, Denson L, Hogan SP. Intestinal macrophage/epithelial cell-derived CCL11/eotaxin-1 mediates eosinophil recruitment and function in pediatric ulcerative colitis. J Immunol. 2008 Nov 15;181(10):7390-9.

Grants

Interleukin-9 in Experimental Intestinal Anaphylaxis. Principal Investigator. National Institute of Health. Dec 2007 - Nov 2012. #NIH RO1 A1073553-01.

Lisa J. Martin, PhD

513-636-1244

lisa.martin@cchmc.org

High Res

Lisa J. Martin, PhD

Associate Professor, UC Department of Pediatrics

Phone: 513-636-1244

Fax: 513-636-7509

Email: lisa.martin@cchmc.org

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Specialties

Clinical Interests

Obesity; genetics; complex traits

Research Interests

The genetics of normal variation, obesity, reproduction, and asthma

Biography

Dr. Martin is an internationally recognized genetic epidemiologist. She has performed genetic analysis of complex traits for over 10 years and has published over 60 peer-reviewed publications (nearly half of which she is first or senior author) in prestigious journals including Nature Genetics, PNAS, and Diabetes. During her post-doctoral training, she received the James V. Neel Young Investigator Award for work on obesity genetics. At Cincinnati Children's, she received the Charlotte R. Schmidlapp Award for being an outstanding female investigator. Her research skills are further reflected in her grant funding; she held a PI on American Diabetes Association Career Development Award and has worked as co-I on multiple grants focusing on the genetics of complex traits.

At Cincinnati Children's, Dr. Martin provides statistical support for human genetic studies. She has been involved in family and population based genetic analyses by collaborating with numerous investigators. As part of this support, Dr. Martin assists in project planning, writing the statistical section of grant proposals, and assists with writing research papers. Recently, Dr. Martin has studied methodological considerations of genome wide association (GWA), especially how to reduce the number of false positives in the context of a million statistical tests1, 2. This work served as a basis for performing GWA at Cincinnati Children's. Indeed, she has designed several GWA studies under consideration for funding.

Education and Training

PhD: (with Honors) University of Kansas, Lawrence KS, 1999

Post-doctoral fellow: Southwest Foundation for Biomedical Research, San Antonio TX, 2002

Publications

View PubMed Publications

Baye TM, Martin LJ, Khurana Hershey GK. Application of genetic/genomic approaches to allergic disorders. J Allergy Clin Immunol. 2010 Sep;126(3):425-36; quiz 437-8.

Sherrill JD, Gao PS, Stucke EM, Blanchard C, Collins MH, Putnam PE, Franciosi JP, Kushner JP, Abonia JP, Assa'ad AH, Kovacic MB, Biagini Myers JM, Bochner BS, He H, Hershey GK, Martin LJ, Rothenberg ME. Variants of thymic stromal lymphopoietin and its receptor associate with eosinophilic esophagitis.J Allergy Clin Immunol. 2010 Jul;126(1):160-5.e3.

Doughty Rice C, Ruschman JG, Martin LJ, Manders JB, Miller E. Retrospective comparison of patient outcomes after in-person and telephone results disclosure counseling for BRCA1/2 genetic testing. Fam Cancer. 2010 Jun;9(2):203-12.

Bollepalli S, Dolan LM, Deka R, Martin LJ. Association of FTO gene variants with adiposity in African-American adolescents. Obesity (Silver Spring). 2010 Oct;18(10):1959-63.

Zarate YA, Martin LJ, Hopkin RJ, Bender PL, Zhang X, Saal HM. Evaluation of growth in patients with isolated cleft lip and/or cleft palate. Pediatrics. 2010 Mar;125(3):e543-9.

Tabangin ME, Woo JG, Martin LJ. The effect of minor allele frequency on the likelihood of obtaining false positives. BMC Proc. 2009 Dec 15;3 Suppl 7:S41.

Martin LJ, Gao G, Kang G, Fang Y, Woo JG. Improving the signal-to-noise ratio in genome-wide association studies. Genet Epidemiol. 2009;33 Suppl 1:S29-32.

Martin LJ, Woo JG, Morrison JA. Evidence of shared genetic effects between pre- and postobesity epidemic BMI levels. Obesity (Silver Spring). 2010 Jul;18(7):1378-82.

Grants

Genetic and Environmental Risk Factors for Hemorrhagic Stroke. Co-Investigator. National Institute of Health. Jul 2008 - Jun 2013. #R01NS036695.

Center Grant, Asthma and Allergic Diseases Cooperative Research Centers (AADCRC) program. Principal Investigator. National Institute of Health. Sep 206 - Aug 2011. #U19 A1070235.

Genetic Studies of Food Allergies Research Program: Candidate Gene Approach for Eosinophilic Esophagitis. Co-Investigator. Department of Defense. Mar 2010 - Feb 2012.

Pursing Perfection in Pediatric Therapeutics. Co-Investigator. National Institute of Health. Sep 2007 - Aug 2011. #U18 HS016957.

USAMRAAGenetic and Epigenetic Differences in Monozygotic Twins with NF1. Co-Investigator. Department of Defense. Jan 2010 - Dec 2011. #NF 093100.

Anil Mishra, PhD

513-636-3347

anil.mishra@cchmc.org

High Res

Anil Mishra, PhD

Associate Professor, UC Department of Pediatrics

Phone: 513-636-3347

Fax: 513-636-3310

Email: anil.mishra@cchmc.org

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Specialties

Pulmonary and esophageal inflammationl; eosinophilic esophagitis; aeroallergen-induced allergic responses in the lung and gastrointestinal tract

Biography

Anil Mishra, PhD, scientific objective includes elucidating the mechanism for the recruitment of inflammatory cells into the mucosal allergic tissue. Dr. Mishra is actively involved in managing a research program focused on understanding the molecular mechanisms of eosinophilic esophageal and lower gastrointestinal tract inflammation.

Dr. Mishra's important contribution was to establish that eosinophils are the resident cell that home prenatally in the gastrointestinal tract and the gastrointestinal tract (esophagus to colon) constitutively expresses eotaxin (an eosinophil selective chemoattractant). These finding indicated that the esophagus is devoid of resident eosinophils at baseline and eotaxin is not sufficient for eosinophil trafficking and homing into the tissues.

In an effort to further understand the mechanisms and significance of eosinophil accumulation in the lung and esophagus at disease states, Dr. Mishra prioritized his research to focus on lung inflammation associated eosinophilic esophagitis, aiming to gain insight into this poorly understood disease. He developed a murine model of asthma associated eosinophilic esophagitis. These findings implicated aeroallergens in the etiology of EE and suggested that esophageal eosinophilic inflammation is mechanistically associated with pulmonary inflammation.

Recently, Dr. Mishra showed that CD4 T cells dependency is less important in the esophageal eosinophilic inflammation compared to the lung and IL-5 induced esophageal eosinophilia promotes tissue remodeling. Dr. Mishra's is an elected fellow of the American Academy of Allergy, Asthma and Immunology and the American Association of Gastroenterology. He has over a 50 articles on molecular mechanisms of the pulmonary toxicity and allergic responses. His research has been supported by the National Institutes of Health to understand the mechanism that induce eosinophilic esophagitis.

Education and Training

PhD: Kanpur University, Kanpur, India.

Publications

View PubMed Publications

Rayapudi M, Mavi P, Zhu X, Pandey AK, Abonia JP, Rothenberg ME, Mishra A. Indoor insect allergens are potent inducers of experimental eosinophilic esophagitis in mice. J Leukoc Biol. 2010 Aug;88(2):337-46.

Zhu X, Wang M, Mavi P, Rayapudi M, Pandey AK, Kaul A, Putnam PE, Rothenberg ME, Mishra A. Interleukin-15 expression is increased in human eosinophilic esophagitis and mediates pathogenesis in mice. Gastroenterology. 2010 Jul;139(1):182-93.e7.

Zhu X, Wang M, Crump CH, Mishra A. An imbalance of esophageal effector and regulatory T cell subsets in experimental eosinophilic esophagitis in mice. Am J Physiol Gastrointest Liver Physiol. 2009 Sep;297(3):G550-8.

Mishra A. Mechanism of eosinophilic esophagitis. Immunol Allergy Clin North Am. 2009 Feb;29(1):29-40, viii. Review.

Palumbo JS, Barney KA, Blevins EA, Shaw MA, Mishra A, Flick MJ, Kombrinck KW, Talmage KE, Souri M, Ichinose A, Degen JL. Factor XIII transglutaminase supports hematogenous tumor cell metastasis through a mechanism dependent on natural killer cell function. J Thromb Haemost. 2008 May;6(5):812-9.

Mishra A, Wang M, Pemmaraju VR, Collins MH, Fulkerson PC, Abonia JP, Blanchard C, Putnam PE, Rothenberg ME. Esophageal remodeling develops as a consequence of tissue specific IL-5-induced eosinophilia. Gastroenterology. 2008 Jan;134(1):204-14.

Mishra A, Wang M, Schlotman J, Nikolaidis NM, DeBrosse CW, Karow ML, Rothenberg ME. Resistin-like molecule-beta is an allergen-induced cytokine with inflammatory and remodeling activity in the murine lung. Am J Physiol Lung Cell Mol Physiol. 2007 Aug;293(2):L305-13.

Mishra A, Schlotman J, Wang M, Rothenberg ME. Critical role for adaptive T cell immunity in experimental eosinophilic esophagitis in mice. J Leukoc Biol. 2007 Apr;81(4):916-24.

Hogan SP, Seidu L, Blanchard C, Groschwitz K, Mishra A, Karow ML, Ahrens R, Artis D, Murphy AJ, Valenzuela DM, Yancopoulos GD, Rothenberg ME. Resistin-like molecule beta regulates innate colonic function: barrier integrity and inflammation susceptibility. J Allergy Clin Immunol. 2006 Jul;118(1):257-68.

Akei HS, Brandt EB, Mishra A, Strait RT, Finkelman FD, Warrier MR, Hershey GK, Blanchard C, Rothenberg ME. Epicutaneous aeroallergen exposure induces systemic TH2 immunity that predisposes to allergic nasal responses. J Allergy Clin Immunol. 2006 Jul;118(1):62-9.

Philip E. Putnam, MD
Director, Endoscopy Services

513-636-4415

philip.putnam@cchmc.org

Kimberly A. Risma, MD, PhD

513-636-6771

kimberly.risma@cchmc.org

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Kimberly A. Risma, MD, PhD

Assistant Professor, UC Department of Pediatrics

Phone: 513-636-6771

Fax: 513-636-4615

Email: kimberly.risma@cchmc.org

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Specialties

Clinical Interests

Immune deficiency; immune dysregulation

Research Interests

Pathophysiology of perforin missense mutations identified in individuals with hemophagocytic lymphohistiocytosis; Molecular mechanisms of primary immune deficiency and dysregulation; Natural killer cell and cytotoxic T lymphocyte cytotoxicity

Biography

Kimberly Risma, MD, PhD, is an Assistant Professor in the Division of Allergy/Immunology at Cincinnati Children’s and the University of Cincinnati College of Medicine.

Dr. Risma graduated magna cum laude with a Bachelor of Arts in Chemistry from Duke University in 1990 and was elected into The Phi Beta Kappa Society. She then matriculated at Case Western Reserve University (CWRU) School of Medicine in the Medical Scientist Training Program (MSTP). In 1996, she completed a PhD in pharmacology. She was selected by the leadership of the CWRU MSTP as the recipient of the 1997 Martin Wahl Memorial Fund Award, given annually to recognize the graduating MD, PhD student who has demonstrated the highest level of independence in research and excellence in research and clinical skills. She was also elected to Alpha Omega Alpha Society in 1997.

In 1997, she enrolled in a Pediatrics residency at Cincinnati Children’s Hospital Medical Center/University of Cincinnati. During the residency program, Dr. Risma was awarded the pediatric resident teaching award by the medical students. She also engaged in translational research studies related to the genetics of asthma under the mentorship of Dr. Gurjit Hershey, resulting in a first author publication as a pediatric resident.

In 2000, Dr. Risma was accepted to the Allergy/Immunology Fellowship at Cincinnati Children’s. In addition to her clinical training, she pursued an innovative research project under the mentorship of Dr. Janos Sumegi and Dr. Alexandra Filipovich. She proposed a mechanism to study the structural and functional impact of perforin missense mutations identified in patients with hemophagocytic lymphohistiocytosis. In 2004 she was awarded the Nezelof Prize for best scientific presentation at the international meeting of the Histiocyte Society. The culmination of her fellowship research project was published in the Journal of Clinical Investigation, 2006.

Upon completion of her fellowship in 2005, Dr. Risma was appointed as an Assistant Professor in the Division of Allergy and Immunology at Cincinnati Children’s Hospital Medical Center. In 2006 Dr. Risma received a Clinical Scientist Development Award from the Doris Duke Charitable Foundation.

Dr. Risma's research program focuses on understanding the molecular mechanisms of immunodeficiency and immune dysregulation in children, especially as it relates to disorders of lymphocyte cytotoxicity. In addition to her research, she sees patients from all around the country in consultation for primary immune deficiency, immune dysregulation, and allergic disorders.

Education and Training

MD: Case Western Reserve University School of Medicine, Cleveland, OH, 1997.

PhD: Case Western Reserve University School of Medicine, Cleveland, OH, 1996.

Residency: Pediatrics, Cincinnati Children's Hospital Medical Center, 1997-2000.

Fellowship: Allergy / Immunology, Cincinnati Children's Hospital Medical Center.

Certification: Pediatrics, 2007; Allergy and Immunology, 2005.

Publications

View PubMed Publications

Sumegi J, Barnes MG, Nestheide SV, Molleran-Lee S, Villanueva J, Zhang K, Risma KA, Grom AA, Filipovich AH. Gene expression profiling of peripheral blood mononuclear cells from children with active hemophagocytic lymphohistiocytosis. Blood. 2011 Apr 14;117(15):e151-60.

Uygungil B, Bleesing JJ, Risma KA, McNeal MM, Rothenberg ME. Persistent rotavirus vaccine shedding in a new case of severe combined immunodeficiency: A reason to screen. J Allergy Clin Immunol. 2010 Jan;125(1):270-1.

Marsh RA, Villanueva J, Kim MO, Zhang K, Marmer D, Risma KA, Jordan MB, Bleesing JJ, Filipovich AH. Patients with X-linked lymphoproliferative disease due to BIRC4 mutation have normal invariant natural killer T-cell populations. Clin Immunol. 2009 Jul;132(1):116-23.

Marsh RA, Villanueva J, Zhang K, Snow AL, Su HC, Madden L, Mody R, Kitchen B, Marmer D, Jordan MB, Risma KA, Filipovich AH, Bleesing JJ. A rapid flow cytometric screening test for X-linked lymphoproliferative disease due to XIAP deficiency. Cytometry B Clin Cytom. 2009 Sep;76(5):334-44.

Urrea Moreno R, Gil J, Rodriguez-Sainz C, Cela E, LaFay V, Oloizia B, Herr AB, Sumegi J, Jordan MB, Risma KA. Functional assessment of perforin C2 domain mutations illustrates the critical role for calcium-dependent lipid binding in perforin cytotoxic function. Blood. 2009 Jan 8;113(2):338-46.

Zhang K, Johnson JA, Biroschak J, Villanueva J, Lee SM, Bleesing JJ, Risma KA, Wenstrup RJ, Filipovich AH. Familial haemophagocytic lymphohistiocytosis in patients who are heterozygous for the A91V perforin variation is often associated with other genetic defects. Int J Immunogenet. 2007 Aug;34(4):231-3.

Thomas H, Risma KA, Graham TB, Brody AS, Deutsch GH, Young LR, Joseph PM. A kindred of children with interstitial lung disease. Chest. 2007 Jul;132(1):221-30.

Bullock JZ, Villanueva JM, Blanchard C, Filipovich AH, Putnam PE, Collins MH, Risma KA, Akers RM, Kirby CL, Buckmeier BK, Assa'ad AH, Hogan SP, Rothenberg ME. Interplay of adaptive th2 immunity with eotaxin-3/c-C chemokine receptor 3 in eosinophilic esophagitis. J Pediatr Gastroenterol Nutr. 2007 Jul;45(1):22-31.

Risma KA, Frayer RW, Filipovich AH, Sumegi J. Aberrant maturation of mutant perforin underlies the clinical diversity of hemophagocytic lymphohistiocytosis. J Clin Invest. 2006 Jan;116(1):182-92.

Karl F. von Tiehl, MD

karl.von_tiehl@cchmc.org

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Karl F. von Tiehl, MD

Assistant Professor, UC Department of Pediatrics

Fax: 513-636-3310

Email: karl.von_tiehl@cchmc.org

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Specialties

Drug allergy; aspirin-exacerbated respiratory disease and other eosinophilic disorders

Biography

Karl F. von Tiehl, MD, is a faculty member of the Division of Allergy & Immunology at Cincinnati Children’s Hospital Medical Center and the University of Cincinnati College of Medicine. He graduated cum laude in Biology from Claremont McKenna College before matriculating at the Medical College of Ohio (now known as the University of Toledo College of Medicine).

After medical school, Dr. von Tiehl completed a 3-year combined internship & residency training program in Internal Medicine at the Scripps Clinic and Scripps Green Hospital (La Jolla, CA), where he stayed on to complete a 2-year fellowship in Allergy & Immunology. His basic science research year was spent at the world-renowned Scripps Research Institute (La Jolla, CA) in the prestigious lab of Dr. Michael B.A. Oldstone, where he performed sentinel work on aspirin-exacerbated respiratory disease (AERD) and varicella zoster virus vaccination failure under Dr. Donald Stevenson, while assisting in chronic viral infection research in the mouse model. Dr. von Tiehl also remained very involved during his fellowship years in clinical trials in AERD patients and in patients with Plavix (clopidogrel) sensitivity. Dr. von Tiehl plans to begin his own clinical trials at CCHMC soon.

Dr. von Tiehl is currently taking new pediatric and adult outpatients with general allergy concerns (e.g. allergic rhinitis, asthma, eczema, hives, angioedema, anaphylaxis, contact dermatitis, and food, drug, latex and venom allergies). He also provides subspecialty consultations for inpatients and for nationwide adult referral patients to the Cincinnati Center for Eosinophilic Disorders (CCED), directed by Dr. Marc Rothenberg.

Education and Training

MD: University of Toledo, Toledo, OH, 2004.

Internship, Residency: Internal Medicine, Scripps Clinic and Scripps Green Hospital, La Jolla, CA, 2004-07.

Fellowship: Allergy and Immunology, Scripps Clinic and Scripps Green Hospital, La Jolla, CA, 2007-09.

Certification: Internal Medicine, 2007-2017. Allergy and Immunology, 2009-2019.

Publications

View PubMed Publications

von Tiehl KF, Stevenson DD, Oldstone MBA. Cytokine Profiles in Aspirin-exacerbated Respiratory Disease Support the Theory of a Chronic Viral Infection. Ann Allergy Asthma Immunol. 2009.

von Tiehl KF, Stevenson DD. A Case of Hydroxyurea-responsive, Non-aspirin-sensitive, Treatment-refractory, Severe, Eosinophilic Nasal Polyposis, Chronic Rhinosinusitis and Asthma. Ann Allergy Asthma Immunol. 2008.

von Tiehl KF, Woessner KM, Simon RA, Stevenson DD. Characterization of Oral Aspirin Challenge-induced Extra-respiratory Reactions in Patients Suspected of Having Aspirin-exacerbated Respiratory Disease. J Allergy Clin Immunol. 2008;121(2):S194.

von Tiehl KF, Price MJ, Valencia R, Ludington KJ, Teirstein PS, Simon RA. Clopidogrel desensitization after drug-eluting stent placement. J Am Coll Cardiol. 2007 Nov 20;50(21):2039-43.