Clinical Interests

Epilepsy; pharmacogenetics; clinical pharmacology

Research Interests

Clinical pharmacology; pharmacogenetics; antiepileptic clinical trials 

Modi AC, Guilfoyle SM, Morita DA, Glauser TA. Development and reliability of a correction factor for parent-reported adherence to pediatric antiepileptic drug therapy. Epilepsia. 2010 Nov 18. doi: 10.1111/j.1528-1167.2010.02789.x.

Modi AC, Monahan S, Daniels D, Glauser TA. Development and validation of the Pediatric Epilepsy Medication Self-Management Questionnaire. Epilepsy Behav. 2010 May;18(1-2):94-9

Glauser TA, Cnaan A, Shinnar S, Hirtz DG, Dlugos D, Masur D, Clark PO, Capparelli EV, Adamson PC; Childhood Absence Epilepsy Study Group. Ethosuximide, valproic acid, and lamotrigine in childhood absence epilepsy. N Engl J Med. 2010 Mar 4;362(9):790-9.

Holland KD, Monahan S, Morita D, Vartzelis G, Glauser TA. Valproate in children with newly diagnosed idiopathic generalized epilepsy. Acta Neurol Scand. 2010 Mar;121(3):149-53.

Pestian J, Spencer M, Matykiewicz P, Zhang K, Vinks AA, Glauser T. Personalizing Drug Selection Using Advanced Clinical Decision Support. Biomed Inform Insights. 2009 Jun 23;2:19-29.

Prows CA, Nick TG, Saldaña SN, Pathak S, Liu C, Zhang K, Daniels ZS, Vinks AA, Glauser TA. Drug-metabolizing enzyme genotypes and aggressive behavior treatment response in hospitalized pediatric psychiatric patients. J Child Adolesc Psychopharmacol. 2009 Aug;19(4):385-94.

Modi AC, King AS, Monahan SR, Koumoutsos JE, Morita DA, Glauser TA. Even a single seizure negatively impacts pediatric health-related quality of life. Epilepsia. 2009 Sep;50(9):2110-6.

Daniels ZS, Nick TG, Liu C, Cassedy A, Glauser TA. Obesity is a common comorbidity for pediatric patients with untreated, newly diagnosed epilepsy. Neurology. 2009 Sep 1;73(9):658-64.

Glauser TA, Sankar R; Co-chairs of the Leadership in Epilepsy, Advocacy, and Development Faculty. Core elements of epilepsy diagnosis and management: expert consensus from the Leadership in Epilepsy, Advocacy, and Development (LEAD) faculty. Curr Med Res Opin. 2008 Dec;24(12):3463-77.

Glauser T, Kluger G, Sachdeo R, Krauss G, Perdomo C, Arroyo S. Rufinamide for generalized seizures associated with Lennox-Gastaut syndrome. Neurology. 2008 May 20;70(21):1950-8.

Pediatric epilepsy; medically refractory epilepsy

Greiner HM, Holland K, Leach JL, Horn PS, Hershey AD, Rose DF. Nonconvulsive status epilepticus: the encephalopathic pediatric patient. Pediatrics. 2012 Feb 13. Epub ahead. 

Greiner HM Tillema JM, Hallinan BE, Holland K, Lee KH, Crone KR.  Corpus callosotomy for treatment of pediatric refractory status epilepticus. Seizure. 2012 Feb 10. Epub ahead.

Greiner HM, Lynch E, Franz D, Krueger DA.  Vigabatrin for treatment of partial-onset childhood epilepsies. Pediatric Neurology. 2012 Feb;46(2):83-8. 

Childers MK, Bogan JR, Bogan DJ, Greiner H, Holder M, Grange R, Kornegay JN. Chronic administration of a leupeptin-derived calpain inhibitor fails to ameliorate severe muscle pathology in a canine model of Duchenne muscular dystrophy. Frontiers in Integrative Physiology. 2012 Jan 9;2(89).

Fujiwara H, Greiner HM, Hemasilpin N, Lee KH, Holland K, Arthur T, Morita DA, Jain SV, Mangano FT, Degrauw T, Rose DF. Ictal MEG onset source localization compared to intracranial EEG and outcome: Improved epilepsy presurgical evaluation in pediatrics. Epilepsy Research 2011 Dec 16. Epub ahead.

Greiner HM, Park YD, Holland K, Horn PS, Byars AW, Mangano FT, Smith JR, Lee MR, Lee KH. Scalp EEG does not predict hemispherectomy outcome. Seizure. 2011 Dec;20(10):758-63.

Greiner H, Leach JL, Lee, KH, Krueger DA. Anti-NMDA receptor encephalitis presenting with imaging findings and clinical features mimicking Rasmussen syndrome. Seizure, 2011 Apr;20(3):266-70.

Greiner HM, Abruzzo TA, Leach JL, Kabbouche M, Zuccarello M. Rotational vertebral artery occlusion in a child with multiple strokes: a case-based update. Childs Nervous System. 2010 Dec;26(12):1669-74. 

Clinical Interests

Epilepsy surgery; spinal deformity; hydrocephalus; oncology

Research Interests

Epilepsy; spine and spinal cord tumors; spinal deformity; hydrocephalus; cerebrovascular disease

Kadar AA, Hearst MJ, Collins MH, Mangano FT, Samy RN. Ewing's Sarcoma of the Petrous Temporal Bone: Case Report and Literature Review. Skull Base. 2010 May;20(3):213-7.

Seo JH, Holland K, Rose D, Rozhkov L, Fujiwara H, Byars A, Arthur T, DeGrauw T, Leach JL, Gelfand MJ, Miles L, Mangano FT, Horn P, Lee KH. Multimodality imaging in the surgical treatment of children with nonlesional epilepsy. Neurology. 2011 Jan 4;76(1):41-8.

Yuan W, Deren KE, McAllister JP 2nd, Holland SK, Lindquist DM, Cancelliere A, Mason M, Shereen A, Hertzler DA, Altaye M, Mangano FT. Diffusion tensor imaging correlates with cytopathology in a rat model of neonatal hydrocephalus. Cerebrospinal Fluid Res. 2010 Nov 5;7:19.

Hertzler DA 2nd, DePowell JJ, Stevenson CB, Mangano FT. Tethered cord syndrome: a review of the literature from embryology to adult presentation. Neurosurg Focus. 2010 Jul;29(1):E1. Review.

Patel NN, Mangano FT, Klimo P Jr. Indirect revascularization techniques for treating moyamoya disease. Neurosurg Clin N Am. 2010 Jul;21(3):553-63. Review.

Air EL, Yuan W, Holland SK, Jones BV, Bierbrauer K, Altaye M, Mangano FT. Longitudinal comparison of pre- and postoperative diffusion tensor imaging parameters in young children with hydrocephalus. J Neurosurg Pediatr. 2010 Apr;5(4):385-91.

Desai R, Stevenson CB, Crawford AH, Durrani AA, Mangano FT. C-1 lateral mass screw fixation in children with atlantoaxial instability: case series and technical report. J Spinal Disord Tech. 2010 Oct;23(7):474-9.

Xiang J, Wang Y, Chen Y, Liu Y, Kotecha R, Huo X, Rose DF, Fujiwara H, Hemasilpin N, Lee K, Mangano FT, Jones B, DeGrauw T. Noninvasive localization of epileptogenic zones with ictal high-frequency neuromagnetic signals. J Neurosurg Pediatr. 2010 Jan;5(1):113-22.

Yuan W, Mangano FT, Air EL, Holland SK, Jones BV, Altaye M, Bierbrauer K. Anisotropic diffusion properties in infants with hydrocephalus: a diffusion tensor imaging study. AJNR Am J Neuroradiol. 2009 Oct;30(9):1792-8.

Xiang J, Liu Y, Wang Y, Kirtman EG, Kotecha R, Chen Y, Huo X, Fujiwara H, Hemasilpin N, Lee K, Mangano FT, Leach J, Jones B, DeGrauw T, Rose D. Frequency and spatial characteristics of high-frequency neuromagnetic signals in childhood epilepsy. Epileptic Disord. 2009 Jun;11(2):113-25.

Clinical Interests

Adjustment and adaptation in pediatric epilepsy

Research Interests

Treatment adherence; health-related quality of life; epilepsy; obesity; cystic fibrosis; sickle cell disease; bariatric surgery

Visit the Modi Lab.

Guilfoyle, S.M., Wagner, J.L, Smith, G., Modi, A.C. (2012). Early Screening and Identification of Psychological Comorbidities in Pediatric Epilepsy is Necessary. Epilepsy and Behavior, 25(4):495-500. PMCID: In process.

Modi, A.C., Wu, Y.P., Guilfoyle, S.M., & Glauser, T.A. (2012). Uninformed Clinical Decisions Resulting From Lack of Adherence Assessment in Children with New Onset Epilepsy. Epilepsy and Behavior, 25, 481-484.PMCID: In process.

Bateman, L.M, Begley, C.E., Ben-Menachem, E., Berg, A.T., Berkovic, S.F., Cascino, G.D., Drazkowski, J., Edwards, J.C., Engle, J., French, J.A., Gilliam, F.D., Hoerth, M.T., Jehi, L.E., Kanner, A.M, Krauss, G.L, Labiner, D.M., Loddenkemper, T., Luder, H.O., McKhann, G.M., McLachlan, R., Modi, A., Pennel, P.B., Shafer, P.O., Sirven, J.I., Stern, J.M., Szaflarski, J.P., Theodore, W.H. (2012). Overcoming barriers to successful epilepsy management. Epilepsy Currents, 12 (4), 158-160. PMCID: PMC342320.

Modi, A.C., Ingerski, L.M., Rausch, J.R., Glauser, T.A. & Drotar, D. (2012). White coat adherence over the first year of therapy in pediatric epilepsy. Journal of Pediatrics, 161(4), 695-699. PMCID: 3426618.

Morita, D.A., Glauser, T.A., & Modi, A.C. (2012).Development and Validation of the Pediatric Epilepsy Side Effects Questionnaire. Neurology, 79(12), 1252-1258. PMCID: 3440448.

Driscoll, KA, Schatschneider, C, McGinnity, K, Modi, AC. (2012). Application of dyadic data analysis in pediatric psychology: Cystic fibrosis health-related quality of life and anxiety in caregiver-child dyads. Journal of Pediatric Psychology, 37, 605-611. PMCID: In process.

Barker, DH, Driscoll, KA, Modi, AC, Light, MJ, Quittner, AL. (2012). Supporting CF disease management during adolescence: The role of family and friends.Child: Care, Health and Development, 38, 497-504. NIHMSID #411712; PMCID: In process.

Modi, A.C., Crosby, L.E., Hines, J., Drotar, D., & Mitchell, M.J. (2012). Feasibility of Web-based Technology to Assess Adherence to Clinic Appointments in Youth with Sickle Cell Disease. Journal of Pediatric Hematology / Oncology,34 (3):e93-6.PMCID: PMC3311776.

Modi, A.C., Pai, A.L., Hommel, K.A., Hood, K.K., Cortina, S., Hilliard, M.E., Guilfoyle, S.M., Gray,W.N., & Drotar, D. (2012). Pediatric self-management: A framework for research, practice, and Policy. Pediatrics. 129(2):e473-85. PMCID: In process.

Clinical Interests

Epilepsy; therapeutic drug management; pharmacogenetics

Research Interests

Clinical pharmacology; population pharmacokinetics; antiepileptic drug tolerability

Modi AC, Guilfoyle SM, Morita DA, Glauser TA. Development and reliability of a correction factor for parent-reported adherence to pediatric antiepileptic drug therapy. Epilepsia. 2011 Feb;52(2):370-6. doi: 10.1111/j.1528-1167.2010.02789.x.

Holland KD, Monahan S, Morita D, Vartzelis G, Glauser TA. Valproate in children with newly diagnosed idiopathic generalized epilepsy. Acta Neurol Scand. 2010 Mar;121(3):149-53.

Modi AC, King AS, Monahan SR, Koumoutsos JE, Morita DA, Glauser TA. Even a single seizure negatively impacts pediatric health-related quality of life. Epilepsia. 2009 Sep;50(9):2110-6.

Modi AC, Morita DA, Glauser TA. One-month adherence in children with new-onset epilepsy: white-coat compliance does not occur. Pediatrics. 2008 Apr;121(4):e961-6.

Air EL, Ostrem JL, Sanger TD, Starr PA. Deep brain stimulation in children: experience and technical pearls. J Neurosurg. 2011.

Air EL, Vagal AA, Kendler A, McPherson CM. Isolated cerebellar mucormycosis, slowly progressive over 1 year in an immunocompetent patient. Surg Neurol Int. 2010 Dec 13;1:81.

Air EL, Yuan W, Holland SK, Jones BV, Bierbrauer K, Altaye M, Mangano FT. Longitudinal comparison of pre- and postoperative diffusion tensor imaging parameters in young children with hydrocephalus. J Neurosurg Pediatr. 2010 Apr;5(4):385-91.

Yuan W, Mangano FT, Air EL, Holland SK, Jones BV, Altaye M, Bierbrauer K. Anisotropic diffusion properties in infants with hydrocephalus: a diffusion tensor imaging study. AJNR Am J Neuroradiol. 2009 Oct;30(9):1792-8.

Air EL, Leach JL, Warnick RE, McPherson CM. Comparing the risks of frameless stereotactic biopsy in eloquent and noneloquent regions of the brain: a retrospective review of 284 cases. J Neurosurg. 2009 Oct;111(4):820-4.

Kissela B, Lindsell CJ, Kleindorfer D, Alwell K, Moomaw CJ, Woo D, Flaherty ML, Air E, Broderick J, Tsevat J. Clinical prediction of functional outcome after ischemic stroke: the surprising importance of periventricular white matter disease and race. Stroke. 2009 Feb;40(2):530-6.

Air EL, Ghomri YM, Tyagi R, Grande AW, Crone K, Mangano FT. Management of vagal nerve stimulator infections: do they need to be removed?J Neurosurg Pediatr. 2009 Jan;3(1):73-8.

Book Chapters

Air EL and Barbaro NM. Radiosurgery for the Treatment of Epilepsy. In Quinones A (Ed), Schmidek and Sweet’s Operative Neurosurgical Techniques: Indications, Methods, and Results. 6th ed. Philadelphia, PA: Elsevier, 2011.

Air EL, Abruzzo TA, Ringer AJ. Embolization of epistaxis. In Connolly ES, McKhann GM, Huang J, Choudhri TF, Komotar RJ, and Mocco J (Eds), Fundamentals of Operative Techniques in Neurosurgery. 2nd ed. New York, NY: Thieme, 2010.

Neurophysiology in the ICU; epilepsy

MD: University of Cincinnati College of Medicine, Cincinnati, OH.

Residency: Pediatrics, West Virginia University, Charleston; Pediatric Neurology, University of Washington.

Fellowship: Pediatric Clinical Neurophysiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.

Certification: American Board of Pediatrics, 2002.

Epilepsy surgery; EEG source localization; functional mapping

Medical School: NSCB Medical College, Rani Durgavati University, Jabalpur, MP, India, 2001.

Residency: All India Institute of Medical Sciences, New Delhi, India, 2010.

Arya R, Shinnar S, Glauser TA. Corticosteroids for the Treatment of Infantile Spams: A Systematic Review. J Child Neurol. 2012. Epub ahead of print.

Sahu JK, Gulati S, Sapra S, Arya R, Chauhan S, Chowdhury MR, Gupta N, Kabra M, Gupta YK, Dwivedi SN, Kalra V. Effectiveness and Safety of Donepezil in Boys With Fragile X Syndrome: A Double-Blind, Randomized, Controlled Pilot Study. J Child Neurol. 2012. Epub ahead of print.

Arya R, Gulati S, Kabra M, Sahu JK, Kalra V. Folic acid supplementation prevents phenytoin-induced gingival overgrowth in children. Neurology. 2011 Apr 12;76(15):1338-43.

Arya R, Gulati S, Kabra M, Sahu JK, Kalra V. Intranasal versus intravenous lorazepam for control of acute seizures in children: a randomized open-label study. Epilepsia. 2011 Apr;52(4):788-93.

Arya R, Kabra M, Gulati S. Epilepsy in children with Down syndrome. Epileptic Disord. 2011 Mar;13(1):1-7.

Arya R, Gulati S. Phenytoin-induced gingival overgrowth. Acta Neurol Scand. 2012 Mar;125(3):149-55.

Arya R, Gulati S, Deopujari S. Management of hepatic encephalopathy in children. Postgrad Med J. 2010 Jan;86(1011):34-41.

Pediatric epilepsy; medically refractory epilepsy

Greiner HM, Holland K, Leach JL, Horn PS, Hershey AD, Rose DF. Nonconvulsive status epilepticus: the encephalopathic pediatric patient. Pediatrics. 2012 Feb 13. Epub ahead. 

Greiner HM Tillema JM, Hallinan BE, Holland K, Lee KH, Crone KR.  Corpus callosotomy for treatment of pediatric refractory status epilepticus. Seizure. 2012 Feb 10. Epub ahead.

Greiner HM, Lynch E, Franz D, Krueger DA.  Vigabatrin for treatment of partial-onset childhood epilepsies. Pediatric Neurology. 2012 Feb;46(2):83-8. 

Childers MK, Bogan JR, Bogan DJ, Greiner H, Holder M, Grange R, Kornegay JN. Chronic administration of a leupeptin-derived calpain inhibitor fails to ameliorate severe muscle pathology in a canine model of Duchenne muscular dystrophy. Frontiers in Integrative Physiology. 2012 Jan 9;2(89).

Fujiwara H, Greiner HM, Hemasilpin N, Lee KH, Holland K, Arthur T, Morita DA, Jain SV, Mangano FT, Degrauw T, Rose DF. Ictal MEG onset source localization compared to intracranial EEG and outcome: Improved epilepsy presurgical evaluation in pediatrics. Epilepsy Research 2011 Dec 16. Epub ahead.

Greiner HM, Park YD, Holland K, Horn PS, Byars AW, Mangano FT, Smith JR, Lee MR, Lee KH. Scalp EEG does not predict hemispherectomy outcome. Seizure. 2011 Dec;20(10):758-63.

Greiner H, Leach JL, Lee, KH, Krueger DA. Anti-NMDA receptor encephalitis presenting with imaging findings and clinical features mimicking Rasmussen syndrome. Seizure, 2011 Apr;20(3):266-70.

Greiner HM, Abruzzo TA, Leach JL, Kabbouche M, Zuccarello M. Rotational vertebral artery occlusion in a child with multiple strokes: a case-based update. Childs Nervous System. 2010 Dec;26(12):1669-74. 

Mechanisms of epileptogenesis

Clinical Interests

Medical and surgical management of epilepsy; sleep disorders

Research Interests

Sleep disorders in children with epilepsy; clinical drug trials

Jain SV, Simakajornboon N, Glauser, TA. Provider practices impact adequate diagnosis of sleep disorders in children with epilepsy. J Child Neurol. 2013 May;28(5):589-95.

Natarajan, N, Jain SV, Chaudhry H, Hallinan BE, Simakajornboon N. Narcolepsy-cataplexy: is streptococcal infection a trigger? J Clin Sleep Med. 2013 Mar 15;9(3):269-70.

Jain SV, Horn PS, Simakajornboon N, Glauser, TA. Obstructive sleep apnea and primary snoring in children with epilepsy. J Child Neurol. 2013 Jan;28(1):77-82.

Jain SV, Simakajornboon N, Arthur TM. Central sleep apnea: does stabilizing sleep improve it?J Child Neurol. 2012 Dec 5. [Epub ahead of print]

Fujiwara H, Greiner HM, Hemasilpin N, Lee KH, Holland-Bouley K, Arthur T, Morita D, Jain SV, Mangano FT, Degrauw T, Rose DF. Ictal MEG onset source localization compared to intracranial EEG and outcome: improved epilepsy presurgical evaluation in pediatrics. Epilepsy Res. 2012 May;99(3):214-24.

Jain SV, Simakajornboon S, Shapiro SM, Morton LD, Leszczyszyn DJ, Simakajornboon N. Obstructive sleep apnea in children with epilepsy: prospective pilot trial. Acta Neurol Scand. 2012 Jan;125(1):e3-6.

Jain SV, Kothare SV. Should we be targeting the sleep-wake patterns of children with epilepsy?  Neuropsychiatry. 2011;1(6), 517–520.  

Book Chapters

Jain SV. Sleep Terrors and Confusional Arousals in Children and Adolescent. In Kothare SV and Ivanenko A. Prasomnia: Clinical Characteristics and Treatment. Springer (in press).

Arya R, Jain SV. Sleep Walking in Children and Adolescent. In Kothare SV and Ivanenko A. Prasomnia: Clinical Characteristics and Treatment. Springer (in press).

Jain SV, Morton LD. Evaluating the Child with Seizure: In Pellock JM, Dodson EW, Bourgeois BF, and Nordlii DR: Pediatric Epilepsy, Diagnosis and Treatment. New York, Demos Medical Publishing: Nov 2007.

Epilepsy

Doctor of Nursing Practice: The Ohio State University, 2012.

MSN, CPNP: University of Cincinnati, Cincinnati, OH.

RN, BSN: College of Mount St. Joseph Cincinnati, OH.

Certification: Pediatric Nurse Practitioner, 2000.

Clinical Interests

Epilepsy; improvement of the quality of life for children with epilepsy; studies of brain and physiology to better understand brain function

Research Interests

Neuropharmacology; epilepsy surgery; central auditory processing; magnetoencephalography; functional cortical mapping; fMRI; SPECT; vagus nerve stimulator; ketogenic diet; language development and language disorders

MD: Case Western Reserve University, Cleveland, Ohio, 1977

Residency: Rainbow Babies and Childrens, Cleveland, Ohio, 1979

Fellowship: University Hospitals, Cleveland, Ohio, 1982

Instructor:, Department of Neurology, University Hospitals, Cleveland, Ohio, 1983

Fellowship: Epilepsy, National Institutes of Health, Bethesda, Md., 1983-1984

Fellowship: Neurophysiology, National Institutes of Health, Bethesda, Md., 1984-1985

Medical Staff Fellow: Clinical Epilepsy Section, National Institutes of Health, 1983-1984

Medical Staff Fellow: EEG Laboratory, National Institutes of Health, 1984-1986

Medical Staff Fellow: Unit on Neurophysiology, National Institutes of Health, 1986-1987

Senior Staff Fellow: Unit on Neurophysiology, National Institutes of Health, 1987-1989

Associate Professor: Department of Neurology, University of New Mexico, Albuquerque, N.M., 1989-1992

Director: Center for Magnetoencephalography, Albuquerque, N.M., 1989-1992

Associate Professor: Department of Pediatrics, University of Tennessee, Memphis, Tenn. 1992-2000

Associate Professor: Department of Neurology, University of Tennessee, Memphis, Tenn. 1992-2000

Adjunct Associate Professor: Memphis Speech and Hearing Center, Department of Audiology, University of Memphis, Tenn., 1998-present.

Division Chief: Child Neurology, Department of Pediatrics, University of Tennessee, 1994-2000

Medical Director: Comprehensive Epilepsy Center, Le Bonheur Children's Medical, Center, Memphis, Tenn., 1992-2000

Director: Cincinnati Children's Neurodiagnostic Laboratory, 2003 to present.

Director: Cincinnati Children's Clinical Neurophysiology Fellowship Program, 2001 to present.

Medical Director: Cincinnati Children's MEG Center, 2005 to present.

Certification: Pediatrics 1984 ; Neurology with special competence in Child Neurology 1984; Clinical Neurophysiology 1986; Added Qualifications in Clinical Neurophysiology 1994

Practice Locations: Cincinnati Children's Hospital Medical Center Main Campus; Outpatient Services -- Anderson

Fellowship: Neurophysiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2008; Neurology, Nationwide Children's Hospital, Columbus, OH, 2007.

Residency: Pediatrics, Nationwide Children's Hospital, Columbus, OH, 2004.

MPH: The Ohio State University College of Public Health, Columbus, OH, 2008.

DO: Kansas City University of Medicine and Biosciences, Kansas City, MO, 2002.

BS: Biology, Lyon College, Batesville, AS, 1997.

Epilepsy; EEG; MEG; Functional MRI

MD/PhD: University of Massachusetts Medical School, Worcester, MA, 2006.

Residency: Child Neurology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2011.

Fellowship: Clinical Neurophysiology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2011.

Certification: Neurology with Special Qualifications in Child Neurology, 2011.

Tenney JR, Schapiro MB. Child Neurology: hemiconvulsion-hemiplegia-epilepsy syndrome. Neurology (Resident and Fellows Section). 2012;79:e1-e4.

Tenney JR, Hopkin RJ, Schapiro MB. Deletion of 14-3-3 and CRK: A clinical syndrome of macrocephaly, developmental delay, and generalized epilepsy. J Child Neurol. 2010;26:223-7.

Tenney JR, Schapiro MB. Child Neurology: Alternating Hemiplegia of Childhood. Neurology (Resident and Fellows Section). 2010;74;e57-9.

Tenney JR, Johnson LH. Moyamoya disease in an 8-year-old boy presenting with weakness. Pediatr Emerg Care. 2009;25;336-8.

Chen W, Tenney J, Kulkarni P, King JA. Imaging Unconditioned Fear Response with Manganese Enhanced MRI (MEMRI). NeuroImage. 2007;37:221-9.

Febo M, Segarra AC, Tenney JR, Brevard ME, Duong TQ, Ferris CF. Imaging cocaine induced changes in the mesocorticolimbic dopaminergic system of conscious rats. J Neurosci Methods. 2004;139:167-76. 

Tenney JR, Marshall PC, King JA, Ferris CF. fMRI of generalized absence status epilepticus in conscious marmoset monkeys reveals corticothalamic activation. Epilepsia. 2004;45:1240-7.

Tenney JR, Duong TQ, King JA, Ferris CF. fMRI of brain activation in a genetic rat model of absence seizures. Epilepsia. 2004;45:576-82.

Tenney JR, Duong TQ, King JA, Ferris CF. fMRI of drug-induced and spontaneous absence epilepsy in awake rats. Epilepsia. 2003;44(S9):43.

Tenney JR, Duong TQ, King JA, Ludwig R, Ferris CF. Corticothalamic modulation  during absence seizures: A functional MRI assessment. Epilepsia. 2003;44:1133-1140.

MD: University of Colorado Health Sciences Center, Denver, CO, 2005.

Residency: Child Neurology, Cincinnati Children’s Hospital, Cincinnati, OH.

Certification: Neurology with Special Qualification in Child Neurology, 2010.

Two Masters of Science: Nursing, The Ohio State University.

Certificate of Authority: Nurse Practitioner and Clinical Nurse Specialist with Prescriptive Authority.

Pediatric epilepsy

Childhood depression and anxiety; epilepsy management; behavior modification; cognitive-behavioral therapy; family functioning; parenting stress and distress; self-management; adherence

PhD: Kent State University, 2009.

Residency: Cincinnati Children’s Hospital Medical Center, 2008-2009.

Fellowship: Cincinnati Children’s Hospital Medical Center, 2009-2011.

Karazsia BT, Guilfoyle SM, Langkamp D, Wildman BG. The mediating role of child behavior on sex differences in pediatric injury risk. Child Care Health Dev. 2011.

Hilliard ME, Guilfoyle SM, Dolan LM, Hood KK. Diabetes-specific family conflict predicts adolescents’ glycemic control one year later. Arch Ped Adolesc Medi. 2011.

Guilfoyle SM, Crimmins NA, Hood KK. Blood glucose monitoring and glycemic control in adolescents with type 1 diabetes: Meter downloads versus self-report. Pediatric Diabetes. 2011.

Guilfoyle SM, Denson LA, Baldassano RN, Hommel KA. Pediatric parenting stress in inflammatory bowel disease: Application of the Pediatric Inventory for Parents. Child Care Health Dev. 2011.

Zeller MH, Guilfoyle SM, Reiter-Purtill J, Ratcliff MB, Inge TH, Long JD. Adolescent bariatric surgery: Caregiver and family functioning across the first post-operative year. Surg Obes Relat Dis. 2011;Mar-Apr;7(2):145-50.

Guilfoyle SM, Goebel JW, Pai ALH. Efficacy and flexibility impact perceived adherence barriers in pediatric kidney post-transplantation. Fam Sys Health. 2011 Mar;29(1):44-54.

Modi AC, Guilfoyle SM, Morita DA, Glauser TA. Development and reliability of a correction factor for parent-reported adherence to pediatric antiepileptic drug therapy. Epilepsia. 2011 Feb;52(2):370-6.

Guilfoyle SM, Zeller MH, Modi AC. Parenting stress impacts obesity-specific health-related quality of life in a pediatric obesity treatment-seeking sample. J Dev Behav Ped. 2010 Jan;31(1):17-25.

Lynch-Jordan AM, Kashikar-Zuck S, Crosby L, Lopez W, Smolyansky B, Parkins I, Luzader C, Hartman A, Guilfoyle SM, Powers S. Applying quality improvement methods to implement a measurement system for chronic pain-related disability. J Ped Psych. 2010;35:32-41.

Book Chapters

Modi AC, Guilfoyle SM. Adherence to Anti-Epileptic Drug Therapy Across the Developmental Life-Span. In J. Pinikahana & C. Walker (Eds). Social and Psychological Correlates of Epilepsy. New York: Nova Science Publishers, 2011.

Clinical Interests

Adjustment and adaptation in pediatric epilepsy

Research Interests

Treatment adherence; health-related quality of life; epilepsy; obesity; cystic fibrosis; sickle cell disease; bariatric surgery

Visit the Modi Lab.

Guilfoyle, S.M., Wagner, J.L, Smith, G., Modi, A.C. (2012). Early Screening and Identification of Psychological Comorbidities in Pediatric Epilepsy is Necessary. Epilepsy and Behavior, 25(4):495-500. PMCID: In process.

Modi, A.C., Wu, Y.P., Guilfoyle, S.M., & Glauser, T.A. (2012). Uninformed Clinical Decisions Resulting From Lack of Adherence Assessment in Children with New Onset Epilepsy. Epilepsy and Behavior, 25, 481-484.PMCID: In process.

Bateman, L.M, Begley, C.E., Ben-Menachem, E., Berg, A.T., Berkovic, S.F., Cascino, G.D., Drazkowski, J., Edwards, J.C., Engle, J., French, J.A., Gilliam, F.D., Hoerth, M.T., Jehi, L.E., Kanner, A.M, Krauss, G.L, Labiner, D.M., Loddenkemper, T., Luder, H.O., McKhann, G.M., McLachlan, R., Modi, A., Pennel, P.B., Shafer, P.O., Sirven, J.I., Stern, J.M., Szaflarski, J.P., Theodore, W.H. (2012). Overcoming barriers to successful epilepsy management. Epilepsy Currents, 12 (4), 158-160. PMCID: PMC342320.

Modi, A.C., Ingerski, L.M., Rausch, J.R., Glauser, T.A. & Drotar, D. (2012). White coat adherence over the first year of therapy in pediatric epilepsy. Journal of Pediatrics, 161(4), 695-699. PMCID: 3426618.

Morita, D.A., Glauser, T.A., & Modi, A.C. (2012).Development and Validation of the Pediatric Epilepsy Side Effects Questionnaire. Neurology, 79(12), 1252-1258. PMCID: 3440448.

Driscoll, KA, Schatschneider, C, McGinnity, K, Modi, AC. (2012). Application of dyadic data analysis in pediatric psychology: Cystic fibrosis health-related quality of life and anxiety in caregiver-child dyads. Journal of Pediatric Psychology, 37, 605-611. PMCID: In process.

Barker, DH, Driscoll, KA, Modi, AC, Light, MJ, Quittner, AL. (2012). Supporting CF disease management during adolescence: The role of family and friends.Child: Care, Health and Development, 38, 497-504. NIHMSID #411712; PMCID: In process.

Modi, A.C., Crosby, L.E., Hines, J., Drotar, D., & Mitchell, M.J. (2012). Feasibility of Web-based Technology to Assess Adherence to Clinic Appointments in Youth with Sickle Cell Disease. Journal of Pediatric Hematology / Oncology,34 (3):e93-6.PMCID: PMC3311776.

Modi, A.C., Pai, A.L., Hommel, K.A., Hood, K.K., Cortina, S., Hilliard, M.E., Guilfoyle, S.M., Gray,W.N., & Drotar, D. (2012). Pediatric self-management: A framework for research, practice, and Policy. Pediatrics. 129(2):e473-85. PMCID: In process.

 PhD: University of Alabama at Birmingham, Birmingham, AL.

Internship: West Virginia University School of Medicine, Morgantown, WV.

Fellowship: Pediatric Neuropsychology, Children's Hospital Medical Center, Cincinnati, OH.

Nuclear medicine

Gelfand MJ, Parisi MT, Treves ST. Pediatric Radiopharmaceutical Administered Doses: 2010 North American Consensus Guidelines. J Nucl Med. 2011 Jan 13.

Seo JH, Holland K, Rose D, Rozhkov L, Fujiwara H, Byars A, Arthur T, Degrauw T, Leach JL, Gelfand MJ, Miles L, Mangano FT, Horn P, Lee KH. Multimodality imaging in the surgical treatment of children with nonlesional epilepsy. Neurology. 2011 Jan 4;76(1):41-8.

Wagner LM, Gelfand MJ, Laor T, Ryckman FC, Al-Ghawi H, Bove KE. A Welcome Surprise: Nodular Fasciitis Presenting as Soft Tissue Sarcoma. J Pediatr Hematol Oncol. 2010 Oct 21.

Gelfand MJ. Dose reduction in pediatric hybrid and planar imaging. Q J Nucl Med Mol Imaging. 2010 Aug;54(4):379-88.

Sharp SE, Shulkin BL, Gelfand MJ, Salisbury S, Furman WL. 123I-MIBG scintigraphy and 18F-FDG PET in neuroblastoma. J Nucl Med. 2009 Aug;50(8):1237-43.

Young LR, Franz DN, Nagarkatte P, Fletcher CD, Wikenheiser-Brokamp KA, Galsky MD, Corbridge TC, Lam AP, Gelfand MJ, McCormack FX. Utility of [18F]2-fluoro-2-deoxyglucose-PET in sporadic and tuberous sclerosis-associated lymphangioleiomyomatosis. Chest. 2009 Sep;136(3):926-33.

Gelfand MJ. Dosimetry of FDG PET/CT and other molecular imaging applications in pediatric patients. Pediatr Radiol. 2009 Feb;39 Suppl 1:S46-56

Gelfand MJ, Gruppo RA, Nasser MP. Ventilation-perfusion scintigraphy in children and adolescents is associated with a low rate of indeterminate studies. Clin Nucl Med. 2008 Sep;33(9):606-9.

Gelfand MJ, Lemen LC. PET/CT and SPECT/CT dosimetry in children: the challenge to the pediatric imager. Semin Nucl Med. 2007 Sep;37(5):391-8. Review.

Wu SW, Graham B, Gelfand MJ, Gruppo RE, Dinopolous A, Gilbert DL. Clinical and positron emission tomography findings of chorea associated with primary antiphospholipid antibody syndrome. Mov Disord. 2007 Sep 15;22(12):1813-5.

Brain tumors; vascular disease 

Phillips CL, Miles L, Jones BV, Sutton M, Crone K, Fouladi M. Medulloblastoma with melanotic differentiation: case report and review of the literature. J Neurooncol. 2010 Oct 16.

Donnelly LF, Gessner KE, Dickerson JM, Koch BL, Towbin AJ, Lehkamp TW, Moskovitz J, Brody AS, Dumoulin CL, Jones BV. Quality initiatives: department scorecard: a tool to help drive imaging care delivery performance. Radiographics. 2010 Nov;30(7):2029-38.

Air EL, Yuan W, Holland SK, Jones BV, Bierbrauer K, Altaye M, Mangano FT. Longitudinal comparison of pre- and postoperative diffusion tensor imaging parameters in young children with hydrocephalus. J Neurosurg Pediatr. 2010 Apr;5(4):385-91.

Morales H, Jones BV, Leach JL, Abruzzo TA. Documented development of a dural arteriovenous fistula in an infant subsequent to sinus thrombosis: case report and review of the literature. Neuroradiology. 2010 Mar;52(3):225-9. Epub 2009 Oct 13. Review.

Yuan W, Mangano FT, Air EL, Holland SK, Jones BV, Altaye M, Bierbrauer K. Anisotropic diffusion properties in infants with hydrocephalus: a diffusion tensor imaging study. AJNR Am J Neuroradiol. 2009 Oct;30(9):1792-8.

Stevens J, Leach JL, Abruzzo T, Jones BV. De novo cerebral arteriovenous malformation: case report and literature review. AJNR Am J Neuroradiol. 2009 Jan;30(1):111-2.

Leach JL, Meyer K, Jones BV, Tomsick TA. Large arachnoid granulations involving the dorsal superior sagittal sinus: findings on MR imaging and MR venography. AJNR Am J Neuroradiol. 2008 Aug;29(7):1335-9. Epub 2008 Apr 16. Review.

Yuan W, Holland SK, Jones BV, Crone K, Mangano FT. Characterization of abnormal diffusion properties of supratentorial brain tumors: a preliminary diffusion tensor imaging study. J Neurosurg Pediatr. 2008 Apr;1(4):263-9.

Karunanayaka PR, Holland SK, Yuan W, Altaye M, Jones BV, Michaud LJ, Walz NC, Wade SL. Neural substrate differences in language networks and associated language-related behavioral impairments in children with TBI: a preliminary fMRI investigation. NeuroRehabilitation. 2007;22(5):355-69.

Yuan W, Holland SK, Schmithorst VJ, Walz NC, Cecil KM, Jones BV, Karunanayaka P, Michaud L, Wade SL. Diffusion tensor MR imaging reveals persistent white matter alteration after traumatic brain injury experienced during early childhood. AJNR Am J Neuroradiol. 2007 Nov-Dec;28(10):1919-25.

Neuroradiology; advanced imaging in epilepsy; multimodal imaging of brain tumors; imaging of stroke; MRI utilization; quality assurance initiatives for neuroradiologic interpretation

Seo JH, Holland K, Rose D, Rozhkov L, Fujiwara H, Byars A, Arthur T, DeGrauw T, Leach JL, Gelfand MJ, Miles L, Mangano FT, Horn P, Lee KH. Multimodality imaging in the surgical treatment of children with nonlesional epilepsy. Neurology. 2011 Jan 4;76(1):41-8.

Greiner H, Leach JL, Lee KH, Krueger DA.  Anti-NMDA receptor encephalitis presenting with imaging findings and clinical features mimicking Rasmussen syndrome. Seizure. 2010 Dec 9.

Greiner HM, Abruzzo TA, Kabbouche M, Leach JL, Zuccarello M. Rotational vertebral artery occlusion in a child with multiple strokes: a case-based update. Childs Nerv Syst. 2010 Dec;26(12):1669-74.

Guthikonda B, Tobler WD Jr, Froelich SC, Leach JL, Zimmer LA, Theodosopoulos PV, Tew JM Jr, Keller JT. Anatomic study of the prechiasmatic sulcus and its surgical implications. Clin Anat. 2010 Sep;23(6):622-8.

Leung R, Samy RN, Leach JL, Murugappan S, Stredney D, Wiet G. Radiographic anatomy of the infracochlear approach to the petrous apex for computer-assisted surgery. Otol Neurotol. 2010 Apr;31(3):419-23.

Stevenson CB, Leach JL, Gupta A, Crone KR. Cystic degeneration of the cerebellar tonsils in pediatric patients with Chiari Type I malformation. J Neurosurg Pediatr. 2009 Dec;4(6):557-63.

Leach JL, Holland SK. Functional MRI in children: clinical and research applications. Pediatr Radiol. 2010 Jan;40(1):31-49. Epub 2009 Nov 24. Review.

Theodosopoulos PV, Leach J, Kerr RG, Zimmer LA, Denny AM, Guthikonda B, Froelich S, Tew JM. Maximizing the extent of tumor resection during transsphenoidal surgery for pituitary macroadenomas: can endoscopy replace intraoperative magnetic resonance imaging? J Neurosurg. 2010 Apr;112(4):736-43.

Morales H, Jones BV, Leach JL, Abruzzo TA. Documented development of a dural arteriovenous fistula in an infant subsequent to sinus thrombosis: case report and review of the literature. Neuroradiology. 2010 Mar;52(3):225-9.

Moore MJ, Vagal AS, Strub WM, Leach JL. Reducing the gray zone: imaging spectrum of hypoperfusion and hypoxic brain injury in adults. Emerg Radiol. 2010 Mar;17(2):123-30.

Research Interests

Dr. Boyd's current research interest is the pathogenesis of interstitial lung disease and developmental lung disorders of infancy. He also has an interest in graduate medical education.

Clinical Interests

Dr. Boyd has worked as an academic pediatric pathologist at Cincinnati Children's since 2008. He functions as a surgical and autopsy pathologist.

Clinical Interests

Pediatric pathology; pediatric neuropathology; pediatric neuromuscular disease

Research Interests

Mitochondrial diseases; coenzyme Q10; pediatric brain tumors; classification and grading of cortical dysplasia; hepatic pathology in pediatric NASH patients and animal models

Seo JH, Holland K, Rose D, Rozhkov L, Fujiwara H, Byars A, Arthur T, DeGrauw T, Leach JL, Gelfand MJ, Miles L, Mangano FT, Horn P, Lee KH. Multimodality imaging in the surgical treatment of children with nonlesional epilepsy. Neurology. 2011 Jan 4;76(1):41-8.

Phillips CL, Miles L, Jones BV, Sutton M, Crone K, Fouladi M. Medulloblastoma with melanotic differentiation: case report and review of the literature. J Neurooncol. 2010 Oct 16.

Miles MV, Putnam PE, Miles L, Tang PH, DeGrauw AJ, Wong BL, Horn PS, Foote HL, Rothenberg ME. Acquired coenzyme Q10 deficiency in children with recurrent food intolerance and allergies. Mitochondrion. 2011 Jan;11(1):127-35.

Kohli R, Kirby M, Xanthakos SA, Softic S, Feldstein AE, Saxena V, Tang PH, Miles L, Miles MV, Balistreri WF, Woods SC, Seeley RJ. High-fructose, medium chain trans fat diet induces liver fibrosis and elevates plasma coenzyme Q9 in a novel murine model of obesity and nonalcoholic steatohepatitis. Hepatology. 2010 Sep;52(3):934-44.

McAuliffe JJ, Loepke AW, Miles L, Joseph B, Hughes E, Vorhees CV. Desflurane, isoflurane, and sevoflurane provide limited neuroprotection against neonatal hypoxia-ischemia in a delayed preconditioning paradigm. Anesthesiology. 2009 Sep;111(3):533-46.

Kurth CD, McCann JC, Wu J, Miles L, Loepke AW. Cerebral oxygen saturation-time threshold for hypoxic-ischemic injury in piglets. Anesth Analg. 2009 Apr;108(4):1268-77.

Loepke AW, Istaphanous GK, McAuliffe JJ 3rd, Miles L, Hughes EA, McCann JC, Harlow KE, Kurth CD, Williams MT, Vorhees CV, Danzer SC. The effects of neonatal isoflurane exposure in mice on brain cell viability, adult behavior, learning, and memory. Anesth Analg. 2009 Jan;108(1):90-104.

Miles L, DeGrauw TJ, Dinopoulos A, Cecil KM, van der Knaap MS, Bove KE. Megalencephalic leukoencephalopathy with subcortical cysts: a third confirmed case with literature review. Pediatr Dev Pathol. 2009 May-Jun;12(3):180-6.

Miles MV, Tang PH, Miles L, Steele PE, Moye MJ, Horn PS. Validation and application of an HPLC-EC method for analysis of coenzyme Q10 in blood platelets. Biomed Chromatogr. 2008 Dec;22(12):1403-8.

Miles MV, Miles L, Tang PH, Horn PS, Steele PE, DeGrauw AJ, Wong BL, Bove KE. Systematic evaluation of muscle coenzyme Q10 content in children with mitochondrial respiratory chain enzyme deficiencies. Mitochondrion. 2008 Mar;8(2):170-80.