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The Comprehensive Epilepsy Center at Cincinnati Children's is home to specialists with a variety of backgrounds and areas of focus. As a team, this diversity makes us better prepared to care for your child's unique needs.
Tracy A. Glauser, MD Associate Director, Cincinnati Children's Research Foundation
Associate Director, Cincinnati Children's Research Foundation
Director, Comprehensive Epilepsy Center
Co-Director, Genetic Pharmacology Service
Professor, UC Department of Pediatrics
Epilepsy; pharmacogenetics; clinical pharmacology
Clinical pharmacology; pharmacogenetics; antiepileptic clinical trials
Modi AC, Guilfoyle SM, Morita DA, Glauser TA. Development and reliability of a correction factor for parent-reported adherence to pediatric antiepileptic drug therapy. Epilepsia. 2010 Nov 18. doi: 10.1111/j.1528-1167.2010.02789.x.
Modi AC, Monahan S, Daniels D, Glauser TA. Development and validation of the Pediatric Epilepsy Medication Self-Management Questionnaire. Epilepsy Behav. 2010 May;18(1-2):94-9
Glauser TA, Cnaan A, Shinnar S, Hirtz DG, Dlugos D, Masur D, Clark PO, Capparelli EV, Adamson PC; Childhood Absence Epilepsy Study Group. Ethosuximide, valproic acid, and lamotrigine in childhood absence epilepsy. N Engl J Med. 2010 Mar 4;362(9):790-9.
Holland KD, Monahan S, Morita D, Vartzelis G, Glauser TA. Valproate in children with newly diagnosed idiopathic generalized epilepsy. Acta Neurol Scand. 2010 Mar;121(3):149-53.
Pestian J, Spencer M, Matykiewicz P, Zhang K, Vinks AA, Glauser T. Personalizing Drug Selection Using Advanced Clinical Decision Support. Biomed Inform Insights. 2009 Jun 23;2:19-29.
Prows CA, Nick TG, Saldaña SN, Pathak S, Liu C, Zhang K, Daniels ZS, Vinks AA, Glauser TA. Drug-metabolizing enzyme genotypes and aggressive behavior treatment response in hospitalized pediatric psychiatric patients. J Child Adolesc Psychopharmacol. 2009 Aug;19(4):385-94.
Modi AC, King AS, Monahan SR, Koumoutsos JE, Morita DA, Glauser TA. Even a single seizure negatively impacts pediatric health-related quality of life. Epilepsia. 2009 Sep;50(9):2110-6.
Daniels ZS, Nick TG, Liu C, Cassedy A, Glauser TA. Obesity is a common comorbidity for pediatric patients with untreated, newly diagnosed epilepsy. Neurology. 2009 Sep 1;73(9):658-64.
Glauser TA, Sankar R; Co-chairs of the Leadership in Epilepsy, Advocacy, and Development Faculty. Core elements of epilepsy diagnosis and management: expert consensus from the Leadership in Epilepsy, Advocacy, and Development (LEAD) faculty. Curr Med Res Opin. 2008 Dec;24(12):3463-77.
Glauser T, Kluger G, Sachdeo R, Krauss G, Perdomo C, Arroyo S. Rufinamide for generalized seizures associated with Lennox-Gastaut syndrome. Neurology. 2008 May 20;70(21):1950-8.
Hansel M Greiner, MD Co-Director, Epilepsy Surgery Program
Co-Director, Epilepsy Surgery Program
Assistant Professor, UC Department of Pediatrics
Pediatric epilepsy; medically refractory epilepsy
Greiner HM, Holland K, Leach JL, Horn PS, Hershey AD, Rose DF. Nonconvulsive status epilepticus: the encephalopathic pediatric patient. Pediatrics. 2012 Feb 13. Epub ahead.
Greiner HM Tillema JM, Hallinan BE, Holland K, Lee KH, Crone KR. Corpus callosotomy for treatment of pediatric refractory status epilepticus. Seizure. 2012 Feb 10. Epub ahead.
Greiner HM, Lynch E, Franz D, Krueger DA. Vigabatrin for treatment of partial-onset childhood epilepsies. Pediatric Neurology. 2012 Feb;46(2):83-8.
Childers MK, Bogan JR, Bogan DJ, Greiner H, Holder M, Grange R, Kornegay JN. Chronic administration of a leupeptin-derived calpain inhibitor fails to ameliorate severe muscle pathology in a canine model of Duchenne muscular dystrophy. Frontiers in Integrative Physiology. 2012 Jan 9;2(89).
Fujiwara H, Greiner HM, Hemasilpin N, Lee KH, Holland K, Arthur T, Morita DA, Jain SV, Mangano FT, Degrauw T, Rose DF. Ictal MEG onset source localization compared to intracranial EEG and outcome: Improved epilepsy presurgical evaluation in pediatrics. Epilepsy Research 2011 Dec 16. Epub ahead.
Greiner HM, Park YD, Holland K, Horn PS, Byars AW, Mangano FT, Smith JR, Lee MR, Lee KH. Scalp EEG does not predict hemispherectomy outcome. Seizure. 2011 Dec;20(10):758-63.
Greiner H, Leach JL, Lee, KH, Krueger DA. Anti-NMDA receptor encephalitis presenting with imaging findings and clinical features mimicking Rasmussen syndrome. Seizure, 2011 Apr;20(3):266-70.
Greiner HM, Abruzzo TA, Leach JL, Kabbouche M, Zuccarello M. Rotational vertebral artery occlusion in a child with multiple strokes: a case-based update. Childs Nervous System. 2010 Dec;26(12):1669-74.
Francesco T. Mangano, DO, FACOS Director, Division of Pediatric Neurosurgery
Director, Division of Pediatric Neurosurgery
Associate Professor, UC Department of Surgery
Epilepsy surgery; spinal deformity; hydrocephalus; oncology.
Epilepsy; spine and spinal cord tumors; spinal deformity; hydrocephalus; cerebrovascular disease.
Francesco Mangano, MD, joined the Division of Pediatric Neurosurgery at Cincinnati Children's in July 2005, as an associate professor of neurosurgery.A graduate of the Philadelphia College of Osteopathic Medicine, Dr. Mangano completed his neurosurgical residency at Long Island Jewish Medical Center in 2004 followed by a fellowship in pediatric neurosurgery at St. Louis Children's Hospital in St. Louis, Missouri. Since joining the faculty of the division of pediatric neurosurgery at this Cincinnati Children's Hospital Medical Center, he has been instrumental in developing our nationally renowned Pediatric Epilepsy Program and is Director of the Pediatric Epilepsy Surgery Program. This program has already given many children a chance to experience a whole new life with marked reduction in the frequency of their debilitating seizures. After extensive evaluation and state of the art imaging and monitoring of the seizures, surgical intervention in many cases can then be exactly targeted to the source of the seizures. An extensive array of surgical techniques may be offered these patients, which ranges from implantation of a vagal nerve stimulator to resection of one whole side of the brain. In addition, he is a co-principal investigator for an NIH-funded multi-institutional research study investigating advanced MRI imaging techniques in children with congenital hydrocephalus. This is only one of his numerous active research projects which have resulted in numerous publications, book chapters and national and international presentations in the fields of epilepsy, diffusion tensor imaging (MRI) of hydrocephalus, traumatic brain injury, and vascular and neoplastic brain lesions. He also has expertise in complex disorders of the spine and spinal cord, including spinal cord tumors, and craniocervical junction.
Dr. Mangano is a member of the American Society of Pediatric Neurosurgeons. He was board certified in 2008 in Neurological Surgery by the American Osteopathic Board of Surgery.
DO: Philadelphia College of Osteopathic Medicine (PCOM), Philadelphia, PA.Residency: NYCOM-Long Island, Jewish Medical Center / North Shore University Health System, New Hyde Park, NY.Fellowship: Washington University School of Medicine-St. Louis Children's Hospital, St. Louis, MO.
Board Certification: Neurological Surgery, American Osteopathic Board of Surgery, 2008.
Kadar AA, Hearst MJ, Collins MH, Mangano FT, Samy RN. Ewing's Sarcoma of the Petrous Temporal Bone: Case Report and Literature Review. Skull Base. 2010 May;20(3):213-7.
Seo JH, Holland K, Rose D, Rozhkov L, Fujiwara H, Byars A, Arthur T, DeGrauw T, Leach JL, Gelfand MJ, Miles L, Mangano FT, Horn P, Lee KH. Multimodality imaging in the surgical treatment of children with nonlesional epilepsy. Neurology. 2011 Jan 4;76(1):41-8.
Yuan W, Deren KE, McAllister JP 2nd, Holland SK, Lindquist DM, Cancelliere A, Mason M, Shereen A, Hertzler DA, Altaye M, Mangano FT. Diffusion tensor imaging correlates with cytopathology in a rat model of neonatal hydrocephalus. Cerebrospinal Fluid Res. 2010 Nov 5;7:19.
Hertzler DA 2nd, DePowell JJ, Stevenson CB, Mangano FT. Tethered cord syndrome: a review of the literature from embryology to adult presentation. Neurosurg Focus. 2010 Jul;29(1):E1. Review.
Patel NN, Mangano FT, Klimo P Jr. Indirect revascularization techniques for treating moyamoya disease. Neurosurg Clin N Am. 2010 Jul;21(3):553-63. Review.
Air EL, Yuan W, Holland SK, Jones BV, Bierbrauer K, Altaye M, Mangano FT. Longitudinal comparison of pre- and postoperative diffusion tensor imaging parameters in young children with hydrocephalus. J Neurosurg Pediatr. 2010 Apr;5(4):385-91.
Desai R, Stevenson CB, Crawford AH, Durrani AA, Mangano FT. C-1 lateral mass screw fixation in children with atlantoaxial instability: case series and technical report. J Spinal Disord Tech. 2010 Oct;23(7):474-9.
Xiang J, Wang Y, Chen Y, Liu Y, Kotecha R, Huo X, Rose DF, Fujiwara H, Hemasilpin N, Lee K, Mangano FT, Jones B, DeGrauw T. Noninvasive localization of epileptogenic zones with ictal high-frequency neuromagnetic signals. J Neurosurg Pediatr. 2010 Jan;5(1):113-22.
Yuan W, Mangano FT, Air EL, Holland SK, Jones BV, Altaye M, Bierbrauer K. Anisotropic diffusion properties in infants with hydrocephalus: a diffusion tensor imaging study. AJNR Am J Neuroradiol. 2009 Oct;30(9):1792-8.
Xiang J, Liu Y, Wang Y, Kirtman EG, Kotecha R, Chen Y, Huo X, Fujiwara H, Hemasilpin N, Lee K, Mangano FT, Leach J, Jones B, DeGrauw T, Rose D. Frequency and spatial characteristics of high-frequency neuromagnetic signals in childhood epilepsy. Epileptic Disord. 2009 Jun;11(2):113-25.
Avani C. Modi, PhD Clinical Psychologist, Behavioral Medicine and Clinical Psychology
Clinical Psychologist, Behavioral Medicine and Clinical Psychology
Co-Director, New Onset Seizure Clinic
Adjustment and adaptation in pediatric epilepsy
Treatment adherence; health-related quality of life; epilepsy; obesity; cystic fibrosis; sickle cell disease; bariatric surgery
Visit the Modi Lab.
Avani Modi, PhD, is an associate professor at the University of Cincinnati College of Medicine and Behavioral Medicine and Clinical Psychology (Center for the Promotion of Treatment Adherence and Self-Management) at Cincinnati Children’s Hospital Medical Center. Her research lab focuses on adherence to pediatric medical regimens, including the measurement of adherence, identifying barriers to effective disease management, and developing and evaluating family-based interventions to improve adherence, especially within pediatric epilepsy. She also has an interest in the development of health-related quality-of-life outcome measures.
Ratcliff M, Zeller MH, Inge TH, Hrovat KB, Modi AC. Feasibility of Ecological Momentary Assessment to Characterize Adolescent Postoperative Diet and Activity Patterns Following Weight Loss Surgery. Surgery for Obesity and Related Diseases. In press.
WuYP, Follansbee-Junger K, Rausch JR, Modi AC. Parent and Family Stress Factors Predict Health-Related Quality of Life in Pediatric Patients with New-Onset Epilepsy. Epilepsia. In press.
Aylward B, Rausch JR, Modi AC. An examination of one-year adherence and persistence rates to antiepileptic medication in children with newly diagnosed epilepsy. Journal of Pediatric Psychology. In press.
Drotar D, Cortina S, Crosby LE, Hommel KA, Modi AC, Pai ALH. Competency-Based Postdoctoral Research Training for Clinical Psychologists: Challenges and Implications. Training and Education in Professional Psychology. In press.
Modi AC, Rausch JR, Glauser TA. Early pediatric antiepileptic drug non-adherence is related to lower long term seizure freedom. Neurology. In press.
Painter E, Rausch JR, Modi AC. Changes in Daily Activity Patterns of Caregivers of Children with Newly Diagnosed Epilepsy: A Case Controlled Design. Epilepsy and Behavior. In press.
Guilfoyle SM, Junger K, Modi AC. Development and Preliminary Implementation of a Psychosocial Service into Standard Medical Care for Pediatric Epilepsy. Clinical Practice in Pediatric Psychology. 2013:1(3), 276-288.
Sawhney P, Modi AC, Jenkins TM, Kollar LM, Zeller M, Inge TH. Predictors and Outcomes of Adolescent Bariatric Support group attendance. Surgery for Obesity and Related Diseases. 2013.
Modi AC, Guilfoyle SM, Rausch JR. Preliminary feasibility, acceptability, and efficacy of an innovative adherence intervention for children with newly diagnosed epilepsy. Journal of Pediatric Psychology. 2013:38, 605-616.
Hilliard ME, Lawrence JM, Modi AC, Anderson A, Crume T, Dolan LM, Merchant AT, Yi-Frazier JP, Hood KK, for the SEARCH for Diabetes in Youth Study Group.Identification of Minimal Clinically Important Difference Scores of the Pediatric Quality of Life Inventory in Children, Adolescents, and Young Adults With Type 1 and Type 2 Diabetes. Diabetes Care. 2013:36(7):1891-1897.
National Institutes of Health-Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD073115)Supporting Treatment Adherence Regimens in Pediatric EpilepsyPrincipal Investigator (60% effort)Entire Project Period: 4/13-3/18.
National Institutes of Health (UM1 DK07249301)Adolescent Bariatrics: Assessing Health Benefits and RisksCo-Investigator (4% effort)Entire Project Period: 7/06-8/16.
Diego A. Morita, MD Co-Director, New Onset Seizure Clinic
Epilepsy; therapeutic drug management; pharmacogenetics
Clinical pharmacology; population pharmacokinetics; antiepileptic drug tolerability
Dr. Morita obtained his Medical Degree with honors from the University of Buenos Aires School of Medicine in Buenos Aires, Argentina. He finished a three-year residency in Pediatrics at Buenos Aires British Hospital in Buenos Aires, Argentina. In 1996, he came to the United States and continued his training in Pediatrics at Miami Children's Hospital in Miami, Florida.
Dr. Morita was then a resident in Neurology at the University of Cincinnati, and later a fellow in Child Neurology at Cincinnati Children's. He completed fellowship training in Clinical Neurophysiology and Epilepsy, and Epilepsy Clinical Neuropharmacology, both at Cincinnati Children's.
After his fellowships, Dr. Morita opened a Child Neurology private practice in Buenos Aires, Argentina, and in 2005 returned and joined the faculty at Cincinnati Children's.
Dr. Morita's interests currently include the objective assessment of antiepileptic drug side effects, pharmacogenetics of antiepileptic drugs, and individualization of drug therapy.
Modi AC, Guilfoyle SM, Morita DA, Glauser TA. Development and reliability of a correction factor for parent-reported adherence to pediatric antiepileptic drug therapy. Epilepsia. 2011 Feb;52(2):370-6. doi: 10.1111/j.1528-1167.2010.02789.x.
Modi AC, Morita DA, Glauser TA. One-month adherence in children with new-onset epilepsy: white-coat compliance does not occur. Pediatrics. 2008 Apr;121(4):e961-6.
Ellen L. Air, MD, PhD Faculty Neurosurgeon, Division of Pediatric Neurosurgery
Faculty Neurosurgeon, Division of Pediatric Neurosurgery
Assistant Professor, UC Department of Neurosurgery
Ellen Air, MD, PhD, joined the Division of Pediatric Neurosurgery in September 2011. After earning her doctorate and medical degrees at the University of Cincinnati College of Medicine, she completed her residency in neurosurgery with the UC Department of Neurosurgery. Dr. Air continued her training with a fellowship in neurosurgical treatment of epilepsy, movement disorders, and pain at the University of California, San Francisco and San Francisco VA Medical Center. Dr. Air specializes in the use of deep brain stimulation for the treatment of dystonia, a disabling movement disorder which often presents in childhood. She brings particular expertise in the use of real-time magnetic resonance imaging to guide deep brain stimulator placement. This approach allows for highly accurate placement with improved patient comfort. In addition, Dr. Air treats a variety of chronic intractable pain syndromes using spinal cord stimulation which delivers electrical stimulation to the spinal cord, interrupting pain signals traveling to the brain.
In addition to seeing patients at Cincinnati Children's Hospital Medical Center, Dr. Air is in private practice with Mayfield Clinic. She also serves as assistant professor of neurosurgery and director of the Division of Epilepsy at UC, and is a member of the UC Epilepsy Center and the UC Neuroscience Institute.
Dr. Air's professional memberships include the American Association of Neurological Surgeons, Congress of Neurological Surgeons, American Society for Stereotactic and Functional Neurosurgery, World Society of Stereotactic and Functional Neurosurgery, Women in Neurosurgery, and the American Medical Association. She is board-eligible with the American Board of Neurological Surgeons (ABNS).
Air EL, Ostrem JL, Sanger TD, Starr PA. Deep brain stimulation in children: experience and technical pearls. J Neurosurg. 2011.
Air EL, Vagal AA, Kendler A, McPherson CM. Isolated cerebellar mucormycosis, slowly progressive over 1 year in an immunocompetent patient. Surg Neurol Int. 2010 Dec 13;1:81. Air EL, Yuan W, Holland SK, Jones BV, Bierbrauer K, Altaye M, Mangano FT. Longitudinal comparison of pre- and postoperative diffusion tensor imaging parameters in young children with hydrocephalus. J Neurosurg Pediatr. 2010 Apr;5(4):385-91. Yuan W, Mangano FT, Air EL, Holland SK, Jones BV, Altaye M, Bierbrauer K. Anisotropic diffusion properties in infants with hydrocephalus: a diffusion tensor imaging study. AJNR Am J Neuroradiol. 2009 Oct;30(9):1792-8. Air EL, Leach JL, Warnick RE, McPherson CM. Comparing the risks of frameless stereotactic biopsy in eloquent and noneloquent regions of the brain: a retrospective review of 284 cases. J Neurosurg. 2009 Oct;111(4):820-4. Kissela B, Lindsell CJ, Kleindorfer D, Alwell K, Moomaw CJ, Woo D, Flaherty ML, Air E, Broderick J, Tsevat J. Clinical prediction of functional outcome after ischemic stroke: the surprising importance of periventricular white matter disease and race. Stroke. 2009 Feb;40(2):530-6. Air EL, Ghomri YM, Tyagi R, Grande AW, Crone K, Mangano FT. Management of vagal nerve stimulator infections: do they need to be removed? J Neurosurg Pediatr. 2009 Jan;3(1):73-8.
Air EL and Barbaro NM. Radiosurgery for the Treatment of Epilepsy. In Quinones A (Ed), Schmidek and Sweet’s Operative Neurosurgical Techniques: Indications, Methods, and Results. 6th ed. Philadelphia, PA: Elsevier, 2011.Air EL, Abruzzo TA, Ringer AJ. Embolization of epistaxis. In Connolly ES, McKhann GM, Huang J, Choudhri TF, Komotar RJ, and Mocco J (Eds), Fundamentals of Operative Techniques in Neurosurgery. 2nd ed. New York, NY: Thieme, 2010.
Todd M. Arthur, MD Pediatric Epileptologist, Division of Neurology
Pediatric Epileptologist, Division of Neurology
Neurophysiology in the ICU; epilepsy
MD: University of Cincinnati College of Medicine, Cincinnati, OH.
Residency: Pediatrics, West Virginia University, Charleston; Pediatric Neurology, University of Washington.
Fellowship: Pediatric Clinical Neurophysiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
Certification: American Board of Pediatrics, 2002.
Ravindra Arya, MD, DM Pediatric Epileptologist, Division of Neurology
Assistant Professor, UC Department of Neurology
UC Department of Pediatrics
Medically refractory epilepsy in children; epilepsy surgery; EEG; ECoG; functional mapping
Ravindra Arya, MD, DM, is a pediatric epileptologist with special interest in medically refractory epilepsy of childhood onset, epilepsy surgery and functional mapping. Children with epilepsy require multi-disciplinary care under supervision of a trained specialist for optimizing their management and to attain best possible outcomes.
Dr. Arya is also motivated towards bridging evidence gaps in patient care through clinical and translational research. He has diverse research interests in the field of childhood epilepsy. He has been principal investigator for two clinical trials: “Intranasal versus intravenous lorazepam for control of acute seizures in children: A randomized, open-labeled non-inferiority trial (NCT 00735527)”, and “Effect of low-dose oral folic-acid supplementation on phenytoin induced gingival overgrowth: A randomized double-blind placebo-controlled trial (NCT 00781196)”. The latter study provided class I evidence for efficacy of a vitamin (folic acid) to prevent a side effect of phenytoin, which is a widely used anti-seizure medication. He has also been principal investigator of an epidemiologic study looking at epilepsy in children with Down syndrome. This study was funded by Council for Scientific and Industrial Research of India.
Currently, he is principal investigator for a study aimed at developing and validating a novel methodology for language mapping in children undergoing invasive evaluation prior to epilepsy surgery, based on signal processing of corticograph data. He is also a co-investigator for other research projects including a retrospective study looking at comparative outcomes and their predictors in children undergoing vagus nerve stimulation and corpus callosotomy; a long term extension of the landmark Childhood Absence Epilepsy study; and a multicentric observational study on pediatric status epilepticus.
Medical School: NSCB Medical College, Rani Durgavati University, Jabalpur, MP, India, 2001.
Residency: Pediatrics, NSCB Medical College, Rani Durgavati University, Jabalpur, MP, India, 2005.
Residency: Pediatric Neurology, All India Institute of Medical Sciences, New Delhi, India, 2010.
Fellowship: Pediatric Epilepsy, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2013.
Arya R, Greiner HM, Lewis A, Horn PS, Mangano FT, Gonsalves C, Holland KD. Predictors of Response to Vagus Nerve Stimulation in Childhood-onset Medically Refractory Epilepsy. J Child Neurol. In press.
Fernández IS, Abend NS, Agadi S, An S, Arya R, Carpenter JL, Chapman KE, Gaillard WD, Glauser TA, Golstein DB, Goldstein JL, Goodkin HP, Hahn CD, Heinzen EL, Mikati MA, Peariso K, Pestian JP, Ream M, Riviello, Jr., JJ, Tasker RC, Williams K, Loddenkemper T, for pediatric Status Epilepticus Research Group (pSERG). Gaps and opportunities in refractory status epilepticus research in children: A multi-center approach by the Pediatric Status Epilepticus Research Group (pSERG). Seizure. In press.
Arya R, Anand V, Chansoria M. Hashimoto Encephalopathy presenting as Progressive Myoclonus Epilepsy syndrome. Eur J Paediatr Neurol. 2013 Jan;17(1):102-4.
Arya R, Shinnar S, Glauser TA. Corticosteroids for the treatment of Infantile Spasms: A Systematic Review. J Child Neurol. 2012 Oct;27(10):1284-8.
Arya R, Greiner HM, Lewis A, Mangano FT, Gonsalves C, Holland KD, Glauser TA. Vagus nerve stimulation for medically refractory absence epilepsy. Seizure. 2013 May;22(4):267-70.
Arya R, Mangano FT, Horn PS, Holland KD, Rose DF, Glauser TA. Adverse events related to extra-operative invasive EEG monitoring with subdural grid electrodes: A systematic review and meta-analysis. Epilepsia. 2013 May;54(5):828-39.
Arya R, Glauser TA. Pharmacotherapy of Focal Epilepsy in Children: A Systematic Review of Approved Agents. CNS Drugs. 2013 Apr;27(4):273-86.
Arya R, Gulati S, Kabra M, Sahu JK, Kalra V. Folic acid supplementation prevents Phenytoin Induced Gingival Overgrowth in Children. Neurology. 2011 Apr 12;76(15):1338-43.
Arya R, Gulati S, Kabra M, Sahu JK, Kalra V. Intranasal versus Intravenous Lorazepam for control of acute seizures in children: A Randomized Open labeled study. Epilepsia. 2011 Apr;52(4):788-93.Arya R, Kabra M, Gulati S. Epilepsy in children with Down syndrome. Epileptic Disord. 2011 Mar;13(1):1-7.
Impact of Initial Therapy and Response On Long Term Outcome in Children with Childhood Absence Epilepsy. Co-investigator. National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health (NIH). Sept 2011 – Aug 2014.
Pediatric Status Epilepticus Research Group. Co-investigator. American Epilepsy Society and Epilepsy Foundation of America Infrastructure Award. Jan 2013 – Dec 2013.
Peggy O. Clark, MSN, APRN, PNP Pediatric Nurse Practitioner, Division of Neurology
Pediatric Nurse Practitioner, Division of Neurology
Peggy Clark received her undergraduate nursing degree from the University of Kentucky. She graduated with honors from the university’s Honors Program, served as student senator for the College of Nursing, and was named Outstanding Nursing Student in her senior year. She has worked at Cincinnati Children’s Hospital Medical Center since receiving her undergraduate nursing degree, and has been a clinical nurse, assistant head nurse, educational nurse specialist, and a nurse practitioner with an epilepsy research focus since 1995. She is a member of the Children’s Medical Center Federal Credit Union Board of Directors, The Greater Cincinnati Epilepsy Foundation Board of Directors, and the APN Professional Inquiry Council.
Barbara E. Hallinan, MD, PhD Pediatric Neurologist
Dent CL, Spaeth JP, Jones BV, Schwartz SM, Glauser TA, Hallinan B, Pearl JM, Khoury PR, Kurth CD. Brain magnetic resonance imaging abnormalities after the Norwood procedure using regional cerebral perfusion. J Thorac Cardiovasc Surg. 2006 Jan;131(1):190-7. Retraction in: J Thorac Cardiovasc Surg. 2006 Jun;131(6):1226.
Dent CL, Spaeth JP, Jones BV, Schwartz SM, Glauser TA, Hallinan B, Pearl JM, Khoury PR, Kurth CD. Brain magnetic resonance imaging abnormalities after the Norwood procedure using regional cerebral perfusion. J Thorac Cardiovasc Surg. 2005 Dec;130(6):1523-30.
Katherine D. Holland, MD, PhD Pediatric Epileptologist
Mechanisms of epileptogenesis
Standridge SM, Holland KD, Horn PS. Cardiac arrhythmias and ictal events within an epilepsy monitoring unit. Pediatr Neurol. 2010 Mar;42(3):201-5.Holland KD, Monahan S, Morita D, Vartzelis G, Glauser TA. Valproate in children with newly diagnosed idiopathic generalized epilepsy. Acta Neurol Scand. 2010 Mar;121(3):149-53.Holland KD, Kearney JA, Glauser TA, Buck G, Keddache M, Blankston JR, Glaaser IW, Kass RS, Meisler MH. Mutation of sodium channel SCN3A in a patient with cryptogenic pediatric partial epilepsy. Neurosci Lett. 2008 Mar 5;433(1):65-70.Holland KD, Glauser TA. Response to carbamazepine in children with newly diagnosed partial onset epilepsy. Neurology. 2007 Aug 7;69(6):596-9.Holland KD, Fleming MT, Cheek S, Moran JL, Beier DR, Meisler MH. De novo exon duplication in a new allele of mouse Glra1 (spasmodic). Genetics. 2006 Dec;174(4):2245-7.
Sejal V. Jain, MD Director, Epilepsy-Sleep Clinical Program
Director, Epilepsy-Sleep Clinical Program
Director, Epilepsy/Clinical Neurophysiology Fellowship Program
Medical and surgical management of epilepsy; sleep disorders
Sleep disorders in children with epilepsy; clinical drug trials
Dr. Jain is a clinical researcher who is trained in pediatric epilepsy and sleep medicine. Her clinical research is focused on sleep disorders in children with epilepsy. The core of her research is to identify the best treatment options for sleep disorders in children with epilepsy and evaluate the impact on seizure control. Dr. Jain is also interested in antiepileptic drug trials.
Dr. Jain developed and is currently directing the Epilepsy-Sleep Clinical Program. She also directs the Epilepsy/Clinical Neurophysiology Fellowship Program. She is ranked among America’s top physicians (Consumer Research Council of America, 2009-2012).
Jain SV, Simakajornboon N, Glauser, TA. Provider practices impact adequate diagnosis of sleep disorders in children with epilepsy. J Child Neurol. 2013 May;28(5):589-95.
Natarajan, N, Jain SV, Chaudhry H, Hallinan BE, Simakajornboon N. Narcolepsy-cataplexy: is streptococcal infection a trigger? J Clin Sleep Med. 2013 Mar 15;9(3):269-70.
Jain SV, Horn PS, Simakajornboon N, Glauser, TA. Obstructive sleep apnea and primary snoring in children with epilepsy. J Child Neurol. 2013 Jan;28(1):77-82.
Jain SV, Simakajornboon N, Arthur TM. Central sleep apnea: does stabilizing sleep improve it?J Child Neurol. 2012 Dec 5. [Epub ahead of print]
Fujiwara H, Greiner HM, Hemasilpin N, Lee KH, Holland-Bouley K, Arthur T, Morita D, Jain SV, Mangano FT, Degrauw T, Rose DF. Ictal MEG onset source localization compared to intracranial EEG and outcome: improved epilepsy presurgical evaluation in pediatrics. Epilepsy Res. 2012 May;99(3):214-24.
Jain SV, Simakajornboon S, Shapiro SM, Morton LD, Leszczyszyn DJ, Simakajornboon N. Obstructive sleep apnea in children with epilepsy: prospective pilot trial. Acta Neurol Scand. 2012 Jan;125(1):e3-6.
Jain SV, Kothare SV. Should we be targeting the sleep-wake patterns of children with epilepsy? Neuropsychiatry. 2011;1(6), 517–520.
Jain SV. Sleep Terrors and Confusional Arousals in Children and Adolescent. In Kothare SV and Ivanenko A. Prasomnia: Clinical Characteristics and Treatment. Springer (in press).
Arya R, Jain SV. Sleep Walking in Children and Adolescent. In Kothare SV and Ivanenko A. Prasomnia: Clinical Characteristics and Treatment. Springer (in press).
Jain SV, Morton LD. Evaluating the Child with Seizure: In Pellock JM, Dodson EW, Bourgeois BF, and Nordlii DR: Pediatric Epilepsy, Diagnosis and Treatment. New York, Demos Medical Publishing: Nov 2007.
Clinical Research Feasibility Funds (CReFF). Principle Investigator. Center for Clinical and Translational Science and Training, Cincinnati Children’s Hospital Medical Center. Apr 2010 - Jul 2013.
Clinical and Translational Science Award (CTSA). Principle Investigator. The National Center for Research Resources, NIH. Jul 2010 - Jul 2013. USPHS Grant # UL1RR026314.
Sally R. Monahan, DNP, APRN, CPNP Pediatric Nurse Practitioner, Division of Neurology
Doctor of Nursing Practice: The Ohio State University, 2012.MSN, CPNP: University of Cincinnati, Cincinnati, OH.
RN, BSN: College of Mount St. Joseph Cincinnati, OH.Certification: Pediatric Nurse Practitioner, 2000.
Douglas F. Rose, MD Pediatric Epileptologist
Epilepsy; improvement of the quality of life for children with epilepsy; studies of brain and physiology to better understand brain function
Neuropharmacology; epilepsy surgery; central auditory processing; magnetoencephalography; functional cortical mapping; fMRI; SPECT; vagus nerve stimulator; ketogenic diet; language development and language disorders
Dr. Rose grew up in Cleveland, Ohio. He and his wife lived briefly in Fairborn and Dayton, Ohio when first married. Subsequently they moved to Washington, DC to study and work at the National Institutes of Health. They then moved to Albuquerque, New Mexico for several years to continue work and research, before moving to Memphis, Tennessee and then Cincinnati.
MD: Case Western Reserve University, Cleveland, Ohio, 1977
Residency: Rainbow Babies and Childrens, Cleveland, Ohio, 1979
Fellowship: University Hospitals, Cleveland, Ohio, 1982
Instructor:, Department of Neurology, University Hospitals, Cleveland, Ohio, 1983
Fellowship: Epilepsy, National Institutes of Health, Bethesda, Md., 1983-1984
Fellowship: Neurophysiology, National Institutes of Health, Bethesda, Md., 1984-1985
Medical Staff Fellow: Clinical Epilepsy Section, National Institutes of Health, 1983-1984
Medical Staff Fellow: EEG Laboratory, National Institutes of Health, 1984-1986
Medical Staff Fellow: Unit on Neurophysiology, National Institutes of Health, 1986-1987
Senior Staff Fellow: Unit on Neurophysiology, National Institutes of Health, 1987-1989
Associate Professor: Department of Neurology, University of New Mexico, Albuquerque, N.M., 1989-1992
Director: Center for Magnetoencephalography, Albuquerque, N.M., 1989-1992
Associate Professor: Department of Pediatrics, University of Tennessee, Memphis, Tenn. 1992-2000
Associate Professor: Department of Neurology, University of Tennessee, Memphis, Tenn. 1992-2000
Adjunct Associate Professor: Memphis Speech and Hearing Center, Department of Audiology, University of Memphis, Tenn., 1998-present.
Division Chief: Child Neurology, Department of Pediatrics, University of Tennessee, 1994-2000
Medical Director: Comprehensive Epilepsy Center, Le Bonheur Children's Medical, Center, Memphis, Tenn., 1992-2000
Director: Cincinnati Children's Neurodiagnostic Laboratory, 2003 to present.
Director: Cincinnati Children's Clinical Neurophysiology Fellowship Program, 2001 to present.
Medical Director: Cincinnati Children's MEG Center, 2005 to present.
Certification: Pediatrics 1984 ; Neurology with special competence in Child Neurology 1984; Clinical Neurophysiology 1986; Added Qualifications in Clinical Neurophysiology 1994
Practice Locations: Cincinnati Children's Hospital Medical Center Main Campus; Outpatient Services -- Anderson
Shannon M. Standridge, MPH, DO
Fellowship: Neurophysiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2008; Neurology, Nationwide Children's Hospital, Columbus, OH, 2007.
Residency: Pediatrics, Nationwide Children's Hospital, Columbus, OH, 2004.
MPH: The Ohio State University College of Public Health, Columbus, OH, 2008.
DO: Kansas City University of Medicine and Biosciences, Kansas City, MO, 2002.
BS: Biology, Lyon College, Batesville, AS, 1997.
Jeffrey R. Tenney, MD, PhD
Epilepsy; EEG; MEG; Functional MRI
Jeffrey Tenney, MD, PhD, is an assistant professor of pediatrics and neurology within the Division of Neurology and Comprehensive Epilepsy Center at Cincinnati Children's. He has a joint academic appointment in the Department of Pediatrics at the University of Cincinnati. Dr. Tenney graduated with his BS and MS from Worcester Polytechnic Institute in Worcester, MA. He earned his MD and PhD degrees at the University of Massachusetts Medical School where he was awarded a pre-doctoral fellowship (F30 NRSA) from the National Institutes of Health. He completed his residency in child neurology followed by a fellowship in clinical neurophysiology at Cincinnati Children’s Hospital Medical Center.
Dr. Tenney’s research interests include mapping the onset and spread of generalized seizures and how these patterns may relate to treatment response and clinical outcome. Dr. Tenney has received a “Taking Flight Award” from CURE (Citizens United for Research in Epilepsy) to fund this work. Clinically, Dr. Tenney evaluates and manages patients with epilepsy in the New Onset Seizure clinic and the Epilepsy Monitoring Unit. He also reads electroencephalograms (EEGs) and has a special interest in patients with Childhood Absence Epilepsy (CAE). Dr. Tenney is a member of the American Epilepsy Society, Organization for Human Brain Mapping and Child Neurology Society.
MD/PhD: University of Massachusetts Medical School, Worcester, MA, 2006.
Residency: Child Neurology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2011.
Fellowship: Clinical Neurophysiology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2011.
Certification: Neurology with Special Qualifications in Child Neurology, 2011.
Tenney JR, Schapiro MB. Child Neurology: hemiconvulsion-hemiplegia-epilepsy syndrome. Neurology (Resident and Fellows Section). 2012;79:e1-e4.
Tenney JR, Hopkin RJ, Schapiro MB. Deletion of 14-3-3 and CRK: A clinical syndrome of macrocephaly, developmental delay, and generalized epilepsy. J Child Neurol. 2010;26:223-7.
Tenney JR, Schapiro MB. Child Neurology: Alternating Hemiplegia of Childhood. Neurology (Resident and Fellows Section). 2010;74;e57-9.
Tenney JR, Johnson LH. Moyamoya disease in an 8-year-old boy presenting with weakness. Pediatr Emerg Care. 2009;25;336-8.
Chen W, Tenney J, Kulkarni P, King JA. Imaging Unconditioned Fear Response with Manganese Enhanced MRI (MEMRI). NeuroImage. 2007;37:221-9.
Febo M, Segarra AC, Tenney JR, Brevard ME, Duong TQ, Ferris CF. Imaging cocaine induced changes in the mesocorticolimbic dopaminergic system of conscious rats. J Neurosci Methods. 2004;139:167-76.
Tenney JR, Marshall PC, King JA, Ferris CF. fMRI of generalized absence status epilepticus in conscious marmoset monkeys reveals corticothalamic activation. Epilepsia. 2004;45:1240-7.
Tenney JR, Duong TQ, King JA, Ferris CF. fMRI of brain activation in a genetic rat model of absence seizures. Epilepsia. 2004;45:576-82.
Tenney JR, Duong TQ, King JA, Ferris CF. fMRI of drug-induced and spontaneous absence epilepsy in awake rats. Epilepsia. 2003;44(S9):43.
Tenney JR, Duong TQ, King JA, Ludwig R, Ferris CF. Corticothalamic modulation during absence seizures: A functional MRI assessment. Epilepsia. 2003;44:1133-1140.
Cameron Thomas, MD, MS
MD: University of Colorado Health Sciences Center, Denver, CO, 2005.
Residency: Child Neurology, Cincinnati Children’s Hospital, Cincinnati, OH.
Certification: Neurology with Special Qualification in Child Neurology, 2010.
MS: Clinical and Translational Research, University of Cincinnati, Cincinnati, OH, 2013.
Michele M. Turner, MSN, APRN, CNS Clinical Nurse Specialist, Neurology / Epilepsy
Clinical Nurse Specialist, Neurology / Epilepsy
Michele M. Turner, MSN, APRN, CNP, has more than 30 years experience in both pediatric and adult neurosciences. She has been a neurology advance practice registered nurse for the last 13 years with a focus in epilepsy. Her subspecialty interest is in the special needs of women with epilepsy. She is an adjunct faculty member at the College of Nursing at Wright State University. She has participated in multiple educational presentations addressing seizures.
Two Masters of Science: Nursing, The Ohio State University.
Certificate of Authority: Nurse Practitioner and Clinical Nurse Specialist with Prescriptive Authority.
Cindy A. Wesolowski, MSN, APRN, CNP Pediatric Nurse Practitioner, Division of Neurology
Shanna M. Guilfoyle, PhD Clinical Psychologist, Behavioral Medicine and Clinical Psychology
Childhood depression and anxiety; epilepsy management; behavior modification; cognitive-behavioral therapy; family functioning; parenting stress and distress; self-management; adherence
Shanna M. Guilfoyle, PhD, is an assistant professor in Behavioral Medicine and Clinical Psychology at Cincinnati Children’s Hospital Medical Center. She currently serves as the clinical psychologist within a multi-disciplinary team in the Division of Neurology’s New Onset Seizure Clinic. She specializes in the assessment and treatment of psychological comorbidities associated with pediatric epilepsy. Broadly, she has studied child, caregiver, and family functioning and their impact on pediatric chronic disease management and adherence across a variety of pediatric chronic conditions (i.e., obesity, transplant, cancer, inflammatory bowel disease, type 1 diabetes). She has served as a clinical interventionist on multiple NIH-funded randomized clinical trials to promote pediatric self-management and medication adherence.
PhD: Kent State University, 2009.
Residency: Cincinnati Children’s Hospital Medical Center, 2008-2009.
Fellowship: Cincinnati Children’s Hospital Medical Center, 2009-2011.
Karazsia BT, Guilfoyle SM, Langkamp D, Wildman BG. The mediating role of child behavior on sex differences in pediatric injury risk. Child Care Health Dev. 2011. Hilliard ME, Guilfoyle SM, Dolan LM, Hood KK. Diabetes-specific family conflict predicts adolescents’ glycemic control one year later. Arch Ped Adolesc Medi. 2011.Guilfoyle SM, Crimmins NA, Hood KK. Blood glucose monitoring and glycemic control in adolescents with type 1 diabetes: Meter downloads versus self-report. Pediatric Diabetes. 2011.
Guilfoyle SM, Denson LA, Baldassano RN, Hommel KA. Pediatric parenting stress in inflammatory bowel disease: Application of the Pediatric Inventory for Parents. Child Care Health Dev. 2011.
Zeller MH, Guilfoyle SM, Reiter-Purtill J, Ratcliff MB, Inge TH, Long JD. Adolescent bariatric surgery: Caregiver and family functioning across the first post-operative year. Surg Obes Relat Dis. 2011;Mar-Apr;7(2):145-50.
Guilfoyle SM, Goebel JW, Pai ALH. Efficacy and flexibility impact perceived adherence barriers in pediatric kidney post-transplantation. Fam Sys Health. 2011 Mar;29(1):44-54.
Modi AC, Guilfoyle SM, Morita DA, Glauser TA. Development and reliability of a correction factor for parent-reported adherence to pediatric antiepileptic drug therapy. Epilepsia. 2011 Feb;52(2):370-6.
Guilfoyle SM, Zeller MH, Modi AC. Parenting stress impacts obesity-specific health-related quality of life in a pediatric obesity treatment-seeking sample. J Dev Behav Ped. 2010 Jan;31(1):17-25.
Lynch-Jordan AM, Kashikar-Zuck S, Crosby L, Lopez W, Smolyansky B, Parkins I, Luzader C, Hartman A, Guilfoyle SM, Powers S. Applying quality improvement methods to implement a measurement system for chronic pain-related disability. J Ped Psych. 2010;35:32-41.
Modi AC, Guilfoyle SM. Adherence to Anti-Epileptic Drug Therapy Across the Developmental Life-Span. In J. Pinikahana & C. Walker (Eds). Social and Psychological Correlates of Epilepsy. New York: Nova Science Publishers, 2011.
Anna Weber Byars, PhD, ABPP-Cn Pediatric Neuropsychologist
Associate Professor, UC Department of Pediatrics
PhD: University of Alabama at Birmingham, Birmingham, AL.
Internship: West Virginia University School of Medicine, Morgantown, WV.
Fellowship: Pediatric Neuropsychology, Children's Hospital Medical Center, Cincinnati, OH.
Michael J. Gelfand, MD Chief, Section of Nuclear Medicine, Department of Radiology
Chief, Section of Nuclear Medicine, Department of Radiology
Professor, UC Department of Radiology
Michael J. Gelfand, MD, is chief of the Section of Nuclear Medicine at Cincinnati Children's Hospital Medical Center.
He received his BA from the University of Michigan and his MD from Stanford University. After two years at the National Institutes of Health, he completed residencies in pediatrics at Cincinnati Children's and nuclear medicine at the University of Cincinnati Medical Center.
Dr. Gelfand's research interests include I-123-MIBG imaging of neuroblastoma, new applications of hybrid imaging (PET/CT, SPECT/CT, PET/MRI) in pediatrics, and radiation dose reduction in nuclear medicine and hybrid imaging.
Dr. Gelfand has served as president of the Society of Nuclear Medicine, and served on the Board of Directors of that organization for 10 years.
Dr. Gelfand co-edited the textbooks Effective Use of Computers in Nuclear Medicine and Pediatric Nuclear Imaging. His publications include 126 journal articles and 31 book chapters. He has been an invited lecturer or visiting professor in France, Germany, the Netherlands, Italy, Argentina, Brazil, Japan and Australia.
Gelfand MJ, Parisi MT, Treves ST. Pediatric Radiopharmaceutical Administered Doses: 2010 North American Consensus Guidelines. J Nucl Med. 2011 Jan 13.
Seo JH, Holland K, Rose D, Rozhkov L, Fujiwara H, Byars A, Arthur T, Degrauw T, Leach JL, Gelfand MJ, Miles L, Mangano FT, Horn P, Lee KH. Multimodality imaging in the surgical treatment of children with nonlesional epilepsy. Neurology. 2011 Jan 4;76(1):41-8.
Wagner LM, Gelfand MJ, Laor T, Ryckman FC, Al-Ghawi H, Bove KE. A Welcome Surprise: Nodular Fasciitis Presenting as Soft Tissue Sarcoma. J Pediatr Hematol Oncol. 2010 Oct 21.
Gelfand MJ. Dose reduction in pediatric hybrid and planar imaging. Q J Nucl Med Mol Imaging. 2010 Aug;54(4):379-88.
Sharp SE, Shulkin BL, Gelfand MJ, Salisbury S, Furman WL. 123I-MIBG scintigraphy and 18F-FDG PET in neuroblastoma. J Nucl Med. 2009 Aug;50(8):1237-43.
Young LR, Franz DN, Nagarkatte P, Fletcher CD, Wikenheiser-Brokamp KA, Galsky MD, Corbridge TC, Lam AP, Gelfand MJ, McCormack FX. Utility of [18F]2-fluoro-2-deoxyglucose-PET in sporadic and tuberous sclerosis-associated lymphangioleiomyomatosis. Chest. 2009 Sep;136(3):926-33.
Gelfand MJ. Dosimetry of FDG PET/CT and other molecular imaging applications in pediatric patients. Pediatr Radiol. 2009 Feb;39 Suppl 1:S46-56
Gelfand MJ, Gruppo RA, Nasser MP. Ventilation-perfusion scintigraphy in children and adolescents is associated with a low rate of indeterminate studies. Clin Nucl Med. 2008 Sep;33(9):606-9.
Gelfand MJ, Lemen LC. PET/CT and SPECT/CT dosimetry in children: the challenge to the pediatric imager. Semin Nucl Med. 2007 Sep;37(5):391-8. Review.
Wu SW, Graham B, Gelfand MJ, Gruppo RE, Dinopolous A, Gilbert DL. Clinical and positron emission tomography findings of chorea associated with primary antiphospholipid antibody syndrome. Mov Disord. 2007 Sep 15;22(12):1813-5.
Blaise V. Jones, MD Chief, Neuroradiology
Associate Director for Clinical Operations
Medical Director, MRI
Pediatric neuroradiology; cerebrovascular disease; neuro-oncology
Blaise V. Jones, MD, completed his undergraduate work at Duke University in 1984 and received his MD from Georgetown University in 1988. Dr. Jones did his radiology residency and neuroradiology fellowship at the University of Cincinnati and a pediatric neuroradiology fellowship at Cincinnati Children's Hospital Medical Center.
Dr. Jones was an assistant professor of Radiology and Pediatrics and section chief of MR imaging at the M.S. Hershey Center of the Penn State University School of Medicine before joining the pediatric neuroradiology faculty at Cincinnati Children's.
He is past president of the American Society for Pediatric Neuroradiology and former chair of the Pediatric Neuroradiology Committee of the Society for Pediatric Radiology. He is an examiner for the American Board of Radiology in Neuroradiology.
Phillips CL, Miles L, Jones BV, Sutton M, Crone K, Fouladi M. Medulloblastoma with melanotic differentiation: case report and review of the literature. J Neurooncol. 2010 Oct 16.
Donnelly LF, Gessner KE, Dickerson JM, Koch BL, Towbin AJ, Lehkamp TW, Moskovitz J, Brody AS, Dumoulin CL, Jones BV. Quality initiatives: department scorecard: a tool to help drive imaging care delivery performance. Radiographics. 2010 Nov;30(7):2029-38.
Air EL, Yuan W, Holland SK, Jones BV, Bierbrauer K, Altaye M, Mangano FT. Longitudinal comparison of pre- and postoperative diffusion tensor imaging parameters in young children with hydrocephalus. J Neurosurg Pediatr. 2010 Apr;5(4):385-91.
Morales H, Jones BV, Leach JL, Abruzzo TA. Documented development of a dural arteriovenous fistula in an infant subsequent to sinus thrombosis: case report and review of the literature. Neuroradiology. 2010 Mar;52(3):225-9. Epub 2009 Oct 13. Review.
Stevens J, Leach JL, Abruzzo T, Jones BV. De novo cerebral arteriovenous malformation: case report and literature review. AJNR Am J Neuroradiol. 2009 Jan;30(1):111-2.
Leach JL, Meyer K, Jones BV, Tomsick TA. Large arachnoid granulations involving the dorsal superior sagittal sinus: findings on MR imaging and MR venography. AJNR Am J Neuroradiol. 2008 Aug;29(7):1335-9. Epub 2008 Apr 16. Review.
Yuan W, Holland SK, Jones BV, Crone K, Mangano FT. Characterization of abnormal diffusion properties of supratentorial brain tumors: a preliminary diffusion tensor imaging study. J Neurosurg Pediatr. 2008 Apr;1(4):263-9.
Karunanayaka PR, Holland SK, Yuan W, Altaye M, Jones BV, Michaud LJ, Walz NC, Wade SL. Neural substrate differences in language networks and associated language-related behavioral impairments in children with TBI: a preliminary fMRI investigation. NeuroRehabilitation. 2007;22(5):355-69.
Yuan W, Holland SK, Schmithorst VJ, Walz NC, Cecil KM, Jones BV, Karunanayaka P, Michaud L, Wade SL. Diffusion tensor MR imaging reveals persistent white matter alteration after traumatic brain injury experienced during early childhood. AJNR Am J Neuroradiol. 2007 Nov-Dec;28(10):1919-25.
James L. Leach, MD Neuroradiologist, Department of Radiology
Neuroradiologist, Department of Radiology
Associate Professor, UC Department of Radiology
Neuroradiology; advanced imaging in epilepsy; multimodal imaging of brain tumors; imaging of stroke; MRI utilization; quality assurance initiatives for neuroradiologic interpretation
James (Jim) Leach, MD, is a neuroradiologist specializing in pediatric neuroradiology at Cincinnati Children's Hospital Medical Center. He grew up in southeastern Ohio and attended Ohio University majoring in Zoology with an emphasis on comparative anatomy. He was inducted into the Alpha Omega Alpha honor society as a third-year student.
After seeing a clinical conference given by Bob Lukin, MD, then chief of Neuroradiology at the University of Cincinnati College of Medicine, he decided on Radiology as a career. He was Chief Resident of Radiology in 1994, and fellow in neuroradiology from 1995-1997 at the University of Cincinnati.
After serving as a staff neuroradiologist at the University of Cincinnati, Dr. Leach spent five years in private practice at Margaret Mary Community Hospital in Batesville, Indiana. Dr. Leach returned to the University of Cincinnati in 2003. He was program director for the Radiology Residency Program from 2003-2006. Dr. Leach began his full time career at Cincinnati Children's in September 2007, focusing on pediatric neuroradiology.
Greiner H, Leach JL, Lee KH, Krueger DA. Anti-NMDA receptor encephalitis presenting with imaging findings and clinical features mimicking Rasmussen syndrome. Seizure. 2010 Dec 9.
Greiner HM, Abruzzo TA, Kabbouche M, Leach JL, Zuccarello M. Rotational vertebral artery occlusion in a child with multiple strokes: a case-based update. Childs Nerv Syst. 2010 Dec;26(12):1669-74.
Guthikonda B, Tobler WD Jr, Froelich SC, Leach JL, Zimmer LA, Theodosopoulos PV, Tew JM Jr, Keller JT. Anatomic study of the prechiasmatic sulcus and its surgical implications. Clin Anat. 2010 Sep;23(6):622-8.
Leung R, Samy RN, Leach JL, Murugappan S, Stredney D, Wiet G. Radiographic anatomy of the infracochlear approach to the petrous apex for computer-assisted surgery. Otol Neurotol. 2010 Apr;31(3):419-23.
Stevenson CB, Leach JL, Gupta A, Crone KR. Cystic degeneration of the cerebellar tonsils in pediatric patients with Chiari Type I malformation. J Neurosurg Pediatr. 2009 Dec;4(6):557-63.
Leach JL, Holland SK. Functional MRI in children: clinical and research applications. Pediatr Radiol. 2010 Jan;40(1):31-49. Epub 2009 Nov 24. Review.
Theodosopoulos PV, Leach J, Kerr RG, Zimmer LA, Denny AM, Guthikonda B, Froelich S, Tew JM. Maximizing the extent of tumor resection during transsphenoidal surgery for pituitary macroadenomas: can endoscopy replace intraoperative magnetic resonance imaging? J Neurosurg. 2010 Apr;112(4):736-43.
Morales H, Jones BV, Leach JL, Abruzzo TA. Documented development of a dural arteriovenous fistula in an infant subsequent to sinus thrombosis: case report and review of the literature. Neuroradiology. 2010 Mar;52(3):225-9.
Moore MJ, Vagal AS, Strub WM, Leach JL. Reducing the gray zone: imaging spectrum of hypoperfusion and hypoxic brain injury in adults. Emerg Radiol. 2010 Mar;17(2):123-30.
Lili Miles, MD Staff Pathologist
Director, Fellowship Training Program
Associate Professor, Division of Pediatric Pathology
Pediatric pathology; pediatric neuropathology; pediatric neuromuscular disease
Mitochondrial diseases; coenzyme Q10; pediatric brain tumors; classification and grading of cortical dysplasia; hepatic pathology in pediatric NASH patients and animal models
Miles MV, Putnam PE, Miles L, Tang PH, DeGrauw AJ, Wong BL, Horn PS, Foote HL, Rothenberg ME. Acquired coenzyme Q10 deficiency in children with recurrent food intolerance and allergies. Mitochondrion. 2011 Jan;11(1):127-35.
Kohli R, Kirby M, Xanthakos SA, Softic S, Feldstein AE, Saxena V, Tang PH, Miles L, Miles MV, Balistreri WF, Woods SC, Seeley RJ. High-fructose, medium chain trans fat diet induces liver fibrosis and elevates plasma coenzyme Q9 in a novel murine model of obesity and nonalcoholic steatohepatitis. Hepatology. 2010 Sep;52(3):934-44.
McAuliffe JJ, Loepke AW, Miles L, Joseph B, Hughes E, Vorhees CV. Desflurane, isoflurane, and sevoflurane provide limited neuroprotection against neonatal hypoxia-ischemia in a delayed preconditioning paradigm. Anesthesiology. 2009 Sep;111(3):533-46.
Kurth CD, McCann JC, Wu J, Miles L, Loepke AW. Cerebral oxygen saturation-time threshold for hypoxic-ischemic injury in piglets. Anesth Analg. 2009 Apr;108(4):1268-77.
Loepke AW, Istaphanous GK, McAuliffe JJ 3rd, Miles L, Hughes EA, McCann JC, Harlow KE, Kurth CD, Williams MT, Vorhees CV, Danzer SC. The effects of neonatal isoflurane exposure in mice on brain cell viability, adult behavior, learning, and memory. Anesth Analg. 2009 Jan;108(1):90-104.
Miles L, DeGrauw TJ, Dinopoulos A, Cecil KM, van der Knaap MS, Bove KE. Megalencephalic leukoencephalopathy with subcortical cysts: a third confirmed case with literature review. Pediatr Dev Pathol. 2009 May-Jun;12(3):180-6.
Miles MV, Tang PH, Miles L, Steele PE, Moye MJ, Horn PS. Validation and application of an HPLC-EC method for analysis of coenzyme Q10 in blood platelets. Biomed Chromatogr. 2008 Dec;22(12):1403-8.
Miles MV, Miles L, Tang PH, Horn PS, Steele PE, DeGrauw AJ, Wong BL, Bove KE. Systematic evaluation of muscle coenzyme Q10 content in children with mitochondrial respiratory chain enzyme deficiencies. Mitochondrion. 2008 Mar;8(2):170-80.
Jessica C. Harvey, MS, RD, LD Registered Dietitian, Division of Nutrition Therapy
Megan L. Lewis, RD, LD Registered Dietitian, Division of Nutrition Therapy
Therese O'Flaherty, MS, RD, LD, CSP Dietician Specialist, Division of Nutrition Therapy
Nicole M. Inman, RNII, BSN, CPN Nurse Practitioner, Comprehensive Epilepsy Center, Neurology
Leslie M. Reed, RN, BSN, CPN Care Manager, Comprehensive Epilepsy Center
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