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Medical / Surgical Team

Maria H. Alonso-Peclet, MD
Surgical Director, Kidney Transplant Program

513-636-4371

maria.alonso@cchmc.org

Conrad R. Cole, MD, MPH, MSc
Director, Intestinal Rehabilitation

513-636-4415

conrad.cole@cchmc.org

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Conrad R. Cole, MD, MPH, MSc

Director, Intestinal Rehabilitation

Associate Professor, UC Department of Pediatrics

Phone: 513-636-4415

Fax: 513-636-7805

Email: conrad.cole@cchmc.org

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Specialties

Clinical Interests

Intestinal failure; short bowel syndrome; growth failure; failure to thrive malabsorption disorders; micronutrient malnutrition

Research Interests

Nutritional and developmental outcomes of infants with intestinal failure and short bowel syndrome; nutritional epidemiology of micronutrient malnutrition in preschool children

Biography

Conrad Cole, MD, is an expert in the management of infants with intestinal failure and short bowel syndrome. He is an associate director of the Pediatric Nutrition and Intestinal Care Center in the Pediatric Gastroenterology, Hepatology and Nutrition Division. In addition, he is an associate professor of Pediatrics at the University of Cincinnati College of Medicine.

Dr. Cole's research interest is in the epidemiology of intestinal failure and it's complications especially in identifying risk factors associated with worsening prognosis. He is also interested in micronutrient malnutrition specifically zinc and iron and how they impact other micronutrients in preschool children especially from low income minority populations.

Prior to joining Cincinnati Children's, Dr. Cole was at Emory University's Schools of Medicine and Public Health. Dr. Cole earned his medical degree from the University of Ibadan, and also completed graduate degrees in public health from Ohio State University and clinical research from Emory University. He received training in nutrition under the mentorship of Fima Lifshitz MD at Maimonides Medical Center and Miami Children's Hospital prior to completing an internship and residency in Pediatrics at the Miami Children's Hospital; and a fellowship in Pediatric Gastroenterology at Cincinnati Children's Hospital Medical Center.

Education and Training

MD: University of Ibadan

MPH: Ohio State University, Columbus, OH

MSc: Emory University, Atlanta, GA

Residency: Miami Children's Hospital, Miami, FL

Fellowship: Cincinnati Children's Hospital Medical Center, Cincinnati, OH

Certification: Pediatrics, Pediatric Gastroenterology

Publications

View PubMed Publications

Cole CR, Grant FK, Swaby-Ellis ED, Smith JL, Jacques A, Northrop-Clewes CA, Caldwell KL, Pfeiffer CM, Ziegler TR. Zinc and iron deficiency and their interrelationship in low-income African American and Hispanic children in Atlanta. American Journal of Clinical Nutrition. 2010;91:1027-1034.

Cole CR, Grant FK, Tangpricha V, Swaby-Ellis ED, Smith JL, Jacques A, Chen HP, Schleicher RL, Ziegler TR. 25-hydroxyvitamin D status of healthy low-income minority children in Atlanta. Pediatrics. 2010;125: 633-639.

Cole C, Freitas A, Clifton MS, Durham MM. Hereditary Multiple Intestinal Atresias: two new cases and review of the literature. Journal of Pediatric Surgery. 2010;45:E21-24.

Frem J, Sarson Y. Sternberg T, Cole CR. Copper supplementation in parenteral nutrition of cholestatic infants. Journal of Pediatric Gastroenterology, Hepatology and Nutrition. 2010;50: 650-654.

Cole CR, Frem JC, Schmotzer B, Gewirtz AT, Meddings JB, Gold BD, Ziegler TR. The rate of bloodstream infection is high in infants with short bowel syndrome: Relationship with small bowel bacterial overgrowth, enteral feeding and inflammatory and immune responses. Journal of Pediatrics. 2010;156: 941-947.e1.

Frem, J, Gold B, Shehada B, Cole C. Reflux masquerader: Acute H. pylori infection in infants. Journal of Pediatric Gastroenterology & Nutrition. 2008;46:589-592.

Cole CR, Hansen N, Huggins R, Ziegler TR, Stoll BJ for the NICHD neonatal research network. Very low birth weight preterm infants with surgical short bowel syndrome: incidence, morbidity and mortality and growth outcomes at 18-22 months. Pediatrics. 2008;112:e573-582.

Michael K. Farrell, MD
Chief-of-Staff

513-636-4415

michael.farrell@cchmc.org

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Michael K. Farrell, MD

Chief-of-Staff

Professor, UC Department of Pediatrics

Phone: 513-636-4415

Fax: 513-636-7805

Email: michael.farrell@cchmc.org

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Specialties

Gastroesophageal reflux; pancreatitis; inflammatory bowel disease; abdominal pain; pediatric nutrition

Education and Training

MD: Jefferson Medical College, Philadelphia, PA, 1970.

Internship: Harrisburg Polyclinic Hospital, Harrisburg, PA, 1970 to 1971.

Residency: Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 1974 to 1976.

Fellowship: Ambulatory Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 1976 to 1977.

Fellowship: Pediatric Gastroenterology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 1977 to 1979.

Publications

View PubMed Publications

Britto MT, Byczkowski TL, Anneken AM, Hausfeld J, Schoettker PJ, Farrell MK, Kotagal UR. Improving access to pediatric subspecialty care: initial failures and lessons learned. Qual Manag Health Care. 2008 Oct-Dec;17(4):320-9.

Stehr W, Farrell MK, Lucky AW, Johnson ND, Racadio JM, Azizkhan RG. Non-endoscopic percutaneous gastrostomy placement in children with recessive dystrophic epidermolysis bullosa. Pediatr Surg Int. 2008 Mar;24(3):349-54.

Azizkhan RG, Stehr W, Cohen AP, Wittkugel E, Farrell MK, Lucky AW, Hammelman BD, Johnson ND, Racadio JM. Esophageal strictures in children with recessive dystrophic epidermolysis bullosa: an 11-year experience with fluoroscopically guided balloon dilatation. J Pediatr Surg. 2006 Jan;41(1):55-60; discussion 55-60.

Noel RJ, Miles L, Putnam PE, Farrell MK. Clinical quiz: rectal prolapse. J Pediatr Gastroenterol Nutr. 2004 Nov;39(5):567, 575.

Pohl JF, Hughes C, Farrell MK. Pathology teach and tell: chronic-onset hereditary tyrosinemia type I. Pediatr Pathol Mol Med. 2001 May-Jun;20(3):241-4.

Perlstein PH, Kotagal UR, Schoettker PJ, Atherton HD, Farrell MK, Gerhardt WE, Alfaro MP. Sustaining the implementation of an evidence-based guideline for bronchiolitis. Arch Pediatr Adolesc Med. 2000 Oct;154(10):1001-7.

Perlstein PH, Kotagal UR, Bolling C, Steele R, Schoettker PJ, Atherton HD, Farrell MK. Evaluation of an evidence-based guideline for bronchiolitis. Pediatrics. 1999 Dec;104(6):1334-41.

Pohl JF, Murarka P, Farrell MK, Bezerra J. Insights. Pylephlebitis. J Pediatr. 1999 Oct;135(4):529.

Dellert SF, Farrell MK, Specker BL, Heubi JE. Bone mineral content in children with short bowel syndrome after discontinuation of parental nutrition. J Pediatr. 1998 Mar;132(3 Pt 1):516-9.

Dellert SF, Nowicki MJ, Farrell MK, Delente J, Heubi JE. The 13C-xylose breath test for the diagnosis of small bowel bacterial overgrowth in children. J Pediatr Gastroenterol Nutr. 1997 Aug;25(2):153-8.

Michael A. Helmrath, MD, MS
Surgical Director, Intestinal Rehabilitation Program

513-636-4371

michael.helmrath@cchmc.org

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Michael A. Helmrath, MD, MS

Surgical Director, Intestinal Rehabilitation Program

Director of Surgical Research

Professor, UC Department of Surgery

Phone: 513-636-4371

Email: michael.helmrath@cchmc.org

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Biography

As a pediatric surgeon, Dr. Helmrath has dedicated his career to the care of patients with intestinal failure. The main focus of his laboratory is directed towards characterizing intestinal stem cells during intestinal adaptation and developing intestinal regenerative strategies. By combining his clinical experience as the surgical director of intestinal research and rehabilitation at Cincinnati Children’s Hospital, his long-term goal is to establish translational therapies for the management of patients with short bowel syndrome.

Education and Training

BA: Miami University, Oxford, OH, 1987.

MD: University of Cincinnati College of Medicine, Cincinnati, OH, 1993.

MS: University of Cincinnati College of Medicine, Cincinnati, OH, 1989.

Publications

View PubMed Publications

Helmrath MA, Shin CE, Fox JW, Erwin CR, Warner BW. Adaptation after small bowel resection is attenuated by sialoadenectomy: The role for endogenous epidermal growth factor. Surgery. 1998;124 (5):848-854.

Erwin CR, Helmrath MA, Shin CE, Falcone RA Jr., Stern LE, Warner BW. Intestinal overexpression of EGF in transgenic mice enhances adaptation after small bowel resection. Am J Physiol Gastrointest Liver Physiol. 1999;277:G533-G540.

Helmrath MA, Fong JJ, Dekaney CM, Henning SJ. Rapid expansion of intestinal secretory lineages following a massive small bowel resection in mice. Am J Physiol Gastrointest Liver Physiol. 2007;292(1): G215-222.

Shroyer NF, Helmrath MA, Wang YYC, Antalffy B, Henning SJ, Zoghbi HY. Intestine specific ablation of Math 1 in mice reveals a role in cellular homeostasis. Gastroenterology. 2007;132(7):2478-2488.

Dekaney CM, Fong JJ, Rigby RJ, Lund PK, Henning SJ, Helmrath MA. Expansion of intestinal stem cells associated with long-term adaptation following ileocecal resection in mice. Am J Physiol Gastrointest Liver Physiol. 2007;293(5): G1013-22.

Dekaney CM, von Allmen DC, Garrison AP, Rigby RJ, Lund PK, Henning SJ, Helmrath MA. Bacterial-dependent up-regulation of intestinal bile acid binding protein and transport is FXR-mediated following ileocecal resection. Surgery. 2008;144(2):174-81.

Garrison AP, Dekaney CM, von Allmen DC, Lund PK, Henning SJ, Helmrath MA. Early but not late administration of glucagons-like peptide-2 following ileocecal resection augments putative intestinal stem cell expansion. Am J Physiol Liver Physiol. 2009;296(3): G643-50.

Rigby RJ, Hunt MR, Scull BP, Simmons JG, Speck KE, Helmrath MA, Lund PK. A new animal model of postsurgical bowel inflammation and fibrosis: the effect of commensal microflora. Gut. 2009;58(8);1104-12.

Garrison AP, Helmrath MA, Dekaney CM. Intestinal Stem Cells. J Pediatr Gastroenterol Nutr. 2009;49(1):2-7.

Speck KE, Garrison AP, Rigby RJ, von Allmen DC, Lund PK, Helmrath MA. Inflammation enhances resection-induced intestinal adaptive growth in IL-10 null mice. J Surg Research. 2011;168(1):62-69.

Grants

Mechanisms of intestinal stem cell expansion following resection. Principal Investigator. National Institute of Diabetes and Digestive and Kidney Disease. Jul 2009 - June 2014. #R01DK083325.

Collaborative approach to the study of intestinal epithelial stem cells. Co-investigator. National Institute of Diabetes and Digestive and Kidney Diseases. Sep 2009 - Aug 2014. #1U01DK085547.

Neointestine from live donors & pluripotent stem cells. Co-investigator. CCST University of Cincinnati. 07/01/11 – 06/30/11.

Adolescent Bariatrics: Assessing Health Benefits & Risk. Co-investigator. National Institute of Diabetes and Digestive and Kidney Diseases. 11/01/11 – 10/31/16. U01 DK072493.

Human Endocrine Cell Development. Co-investigator. National Institute of Diabetes and Digestive and Kidney Diseases. 04/01/12 – 03/31/17. R01 DK092456.

Samuel A. Kocoshis, MD
Medical Director, Intestinal Care Center

513-636-4415

samuel.kocoshis@cchmc.org

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Samuel A. Kocoshis, MD

Medical Director, Intestinal Care Center

Medical Director, Small Bowel Transplantation Program

Professor, UC Department of Pediatrics

Phone: 513-636-4415

Fax: 513-636-7805

Email: samuel.kocoshis@cchmc.org

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Specialties

Clinical Interests

Management of complex intestinal and liver disease; small bowel transplantation; general disorders of the gastrointestinal tract

Research Interests

Altered bile acid metabolism in gastrointestinal disease; small bowel transplantation; inflammatory bowel disease; short bowel syndrome

Biography

Samuel Kocoshis, MD, is an expert in the management of complex intestinal and liver disease at Cincinnati Children's Hospital Medical Center.

Dr. Kocoshis is the director of the Pediatric Nutrition and Intestinal Care Center in the Pediatric Gastroenterology, Hepatology and Nutrition Division, and is also the medical director of the Small Intestinal Transplantation Program. In addition, he is professor of pediatrics at the University of Cincinnati College of Medicine.

Dr. Kocoshis' long-standing research interest has been altered bile acid metabolism in gastrointestinal disease. His current clinical research program focuses upon intestinal adaptation following massive small intestinal resection, as well as the immunology of intestinal transplantation.

Prior to joining Cincinnati Children's, Dr. Kocoshis was chief of Pediatric Gastroenterology and co-director of the Intestinal Care Center at Children's Hospital of Pittsburgh, and professor of pediatrics at the University of Pittsburgh School of Medicine.

Dr. Kocoshis earned his bachelor's degree from DePauw University and his medical degree from the Medical College of Wisconsin. He completed an internship in pediatrics at the West Virginia University Medical Center; a residency in pediatrics at Children's Hospital of Pittsburgh; and a clinical fellowship in gastroenterology at Yale University School of Medicine.

Education and Training

BS: DePauw University, Greencastle, IN.

MD: Medical College of Wisconsin, Milwaukee, WI.

Residency: Children's Hospital of Pittsburgh, Pittsburgh, PA.

Fellowship: Yale University School of Medicine, New Haven, CT.

Publications

View PubMed Publications

Kocoshis SA. Medical management of pediatric intestinal failure. Semin Pediatr Surg. 2010 Feb;19(1):20-6. Review.

Wessel JJ, Kocoshis SA. Nutritional management of infants with short bowel syndrome. Semin Perinatol. 2007 Apr;31(2):104-11. Review.

Nathan JD, Rudolph JA, Kocoshis SA, Alonso MH, Ryckman FC, Tiao GM. Isolated liver and multivisceral transplantation for total parenteral nutrition-related end-stage liver disease. J Pediatr Surg. 2007 Jan;42(1):143-7.

Kocoshis S. Small Intestinal Failure in Children. Curr Treat Options Gastroenterol. 2001 Oct;4(5):423-432.

Jaimie D. Nathan, MD
Surgical Director, Intestinal Transplant Program

513-636-4371

jaimie.nathan@cchmc.org

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Jaimie D. Nathan, MD

Surgical Director, Intestinal Transplant Program

Assistant Professor, Division of Pediatric Surgery

Phone: 513-636-4371

Fax: 513-636-7657

Email: jaimie.nathan@cchmc.org

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Specialties

Hepatobiliary and pancreatic disease; liver, kidney, and intestinal transplantation; pediatric surgical oncology; neonatal surgery; minimally invasive surgery

Education and Training

BS: Yale University, New Haven, CT, 1993.

MD: Yale University, New Haven, CT, 1998.

Residency: General Surgery, Duke University Medical Center, Durham, NC, 1998-2000 and 2002-2005.

Surgical Research Fellowship: Duke University Medical Center, Durham, NC, 2000-2002.

Pediatric Surgery Fellowship: Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2005-2007.

Transplant Surgery Fellowship: University of Cincinnati, Cincinnati, OH, 2007-2009.

Certification: American Board of Surgery, General Surgery, 2007; American Board of Surgery, Pediatric Surgery, 2008; American Society of Transplant Surgeons Certification, 2009.

Publications

View PubMed Publications

Prada CE, Kaul A, Hopkin RJ, Page KI, Nathan JD, Bartholomew DW, Cohen MB, Heubi JE, Leslie ND, Burrow TA. Recurrent pancreatitis in ornithine transcarbamylase deficiency. Mol Genet Metab. 2012 Aug;106(4):482-484.

Bondoc AJ, Taylor JA, Alonso MH, Nathan JD, Wang Y, Balistreri WF, Bezerra JA, Ryckman FC, Tiao GM. The beneficial impact of revision of Kasai portoenterostomy for biliary atresia: an institutional study. Ann Surg. 2012 Mar;255(3):570-576.

Shin CR, Nathan J, Alonso M, Yazigi N, Kocoshis S, Tiao G, Davies SM. Incidence of acute and chronic graft-versus-host disease and donor T-cell chimerism after small bowel or combined organ transplantation. J Pediatr Surg. 2011 Sep;46(9):1732-1738.

Vigna SR, Shahid RA, Nathan JD, McVey DC, Liddle RA. Leukotriene B4 mediates inflammation via TRPV1 in duct obstruction-induced pancreatitis in rats. Pancreas. 2011 Jul;40(5):708-714.

Nathan JD, Romac J, Peng RY, Peyton M, Rockey DC, Liddle RA. Protection against chronic pancreatitis and pancreatic fibrosis in mice overexpressing pancreatic secretory trypsin inhibitor. Pancreas. 2010 Jan;39(1):e24-30.

Ryckman FC, Bucuvalas JC, Nathan J, Alonso M, Tiao G, Balistreri WF. Outcomes following liver transplantation. Semin Pediatr Surg. 2008 May;17(2):123-30.

Follmar KE, Condron SA, Turner II, Nathan JD, Ludwig KA. Treatment of metronidazole-refractory Clostridium difficile enteritis with vancomycin. Surg Infect. 2008 9:195-200.

Patel MB, Nathan JD, Frush DP, Rice HE. Nonoperative management of asymptomatic traumatic pulmonary hernia in a young child. J Trauma. 2007 62:234-235.

Nathan JD, Romac J, Peng RY, Peyton M, MacDonald RJ, Liddle RA. Transgenic expression of pancreatic secretory trypsin inhibitor-I ameliorates secretagogue-induced pancreatitis in mice. Gastroenterology. 2005 128:717-727.

Frederick C. Ryckman, MD
Professor of Surgery / Transplantation

513-636-4371

frederick.ryckman@cchmc.org

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Frederick C. Ryckman, MD

Professor of Surgery / Transplantation

Sr. Vice President - Medical Operations

Professor, Division of Pediatric Surgery

Phone: 513-636-4371

Fax: 513-636-7657

Email: frederick.ryckman@cchmc.org

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Specialties

Transplantation; liver; kidney transplantation; small intestine; biliary disease; Extracorporeal membrane oxygenation (ECMO); minimally invasive surgery; chest wall abnormalities

Biography

Frederick C. Ryckman, MD, is clinical director of the Pediatric General and Thoracic Surgery Division.

Dr. Ryckman is also vice president of System Capacity & Perioperative Operations.

Dr. Ryckman is also a pediatric surgeon at the Fetal Care Center of Cincinnati.

Education and Training

BS: Lyman Briggs College of Science and Mathematics, Michigan State University, East Lansing, MI, 1969 to 1973.

MD: University of Michigan Medical School, Ann Arbor, MI, 1977.

Residency: University of Florida Medical Center, Gainesville, FL, 1977 to 1982.

Fellowship: Pediatric Surgery, Children's Hospital Medical Center, Cincinnati, OH, 1982 to 1984.

Certification: National Board of Medical Examiners, 1977; American Board of Surgery, 1983; recertification, 1993; Certificate of Special Competence in Pediatric Surgery, 1986; recertification, 1993.

Publications

View PubMed Publications

Wagner LM, Gelfand MJ, Laor T, Ryckman FC, Al-Ghawi H, Bove KE. A Welcome Surprise: Nodular Fasciitis Presenting as Soft Tissue Sarcoma. J Pediatr Hematol Oncol. 2010 Oct 21.

Taylor JA, Ryckman FC. Management of small bowel volvulus around feeding Roux-en-Y limbs. Pediatr Surg Int. 2010 Apr;26(4):439-42.

Ryckman FC, Yelton PA, Anneken AM, Kiessling PE, Schoettker PJ, Kotagal UR. Redesigning intensive care unit flow using variability management to improve access and safety. Jt Comm J Qual Patient Saf. 2009 Nov;35(11):535-43.

Rattan AS, Laor T, Ryckman FC, Brody AS. Pectus excavatum imaging: enough but not too much. Pediatr Radiol. 2010 Feb;40(2):168-72.

Propst EJ, Lin EP, Istaphanous GK, Boesch RP, Ryckman FC, Cotton RT, Rutter MJ. Management of traumatic tracheobronchial separation in a teenager using a fabricated extra-long endotracheal tube. Int J Pediatr Otorhinolaryngol. 2009 Aug;73(8):1163-7.

Ryckman FC, Schoettker PJ, Hays KR, Connelly BL, Blacklidge RL, Bedinghaus CA, Sorter ML, Friend LC, Kotagal UR. Reducing surgical site infections at a pediatric academic medical center. Jt Comm J Qual Patient Saf. 2009 Apr;35(4):192-8.

Dickie B, Dasgupta R, Nair R, Alonso MH, Ryckman FC, Tiao GM, Adams DM, Azizkhan RG. Spectrum of hepatic hemangiomas: management and outcome. J Pediatr Surg. 2009 Jan;44(1):125-33.

Ryckman FC, Bucuvalas JC, Nathan J, Alonso M, Tiao G, Balistreri WF. Outcomes following liver transplantation. Semin Pediatr Surg. 2008 May;17(2):123-30.

Sparling KW, Ryckman FC, Schoettker PJ, Byczkowski TL, Helpling A, Mandel K, Panchanathan A, Kotagal UR. Financial impact of failing to prevent surgical site infections. Qual Manag Health Care. 2007 Jul-Sep;16(3):219-25.

Andrew Patrick South, MD, MPH
Assistant Professor, Department of Pediatrics

513-803-0998

andrew.south@cchmc.org

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Andrew P. South, MD, MPH

Assistant Professor, Department of Pediatrics

Assistant Professor, UC Department of Pediatrics

Phone: 513-803-0998

Fax: 513-803-0968

Email: andrew.south@cchmc.org

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Specialties

Epidemiology and prevention of late-preterm birth; long term outcome of infants born with gastroschisis

Education and Training

MD: Case Western Reserve University, Cleveland, OH, 2000.

Residency: Pediatrics, University of North Carolina Children’s Hospital, Chapel Hill, NC.

Fellowship: Neonatology, University of North Carolina Children’s Hospital, Chapel Hill, NC.

Certification: Pediatrics, 2004; Neonatology, 2008.

Publications

View PubMed Publications

Slaughter JL, Pakrashi T, Jones DE, South AP, Shah TA. Echocardiographic detection of pulmonary hypertension in extremely low birth weight infants with bronchopulmonary dysplasia requiring prolonged positive pressure ventilation. J Perinatol. 2011 Feb 10.

South AP, Wessel JJ, Sberna A, Patel M, Morrow AL. Hospital readmission among infants with gastroschisis. J Perinatol. 2011 Feb 10.

South AP, Jones DE, Hall ES, Huo S, Meinzen-Derr J, Liu L, Greenberg JM. Spatial Analysis of Preterm Birth Demonstrates Opportunities for Targeted Intervention. Matern Child Health J. 2011 Feb 3.

Winik BC, Asial RA, McGrath JA, South AP, Boente MC. Acantholytic ectodermal dysplasia: clinicopathological study of a new desmosomal disorder. Br J Dermatol. 2009 Apr;160(4):868-74.

South AP, Marshall DD, Bose CL, Laughon MM. Growth and neurodevelopment at 16 to 24 months of age for infants born with gastroschisis. J Perinatol. 2008 Oct;28(10):702-6.

South MMT, Strauss RA, South AP, Boggess JF, Thorp JM. The use of non-nutritive sucking to decrease the physiologic pain response during neonatal circumcision: A randomized controlled trial. Am J of Obstet and Gynec 2005;193:537-43.

Grischkan J, Storfer-Isser A, Rosen CL, Larkin EK, Kirchner HL, South A, Wilson-Costello DC, Martin RJ, Redline S. Variation in childhood asthma among former preterm infants. J Pediatr 2004;144:321-6.

Greg M. Tiao, MD
Surgical Director, Liver Transplantation

513-636-4371

greg.tiao@cchmc.org

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Greg M. Tiao, MD

Surgical Director, Liver Transplantation

Director, Small Bowel Program

Associate Director, Pediatric Surgery Training Program

Pediatric Surgeon

Associate Professor, Division of Pediatric Surgery

Phone: 513-636-4371

Fax: 513-636-7657

Email: greg.tiao@cchmc.org

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Specialties

Biliary atresia

Biography

As a pediatric surgeon and a transplant surgeon, Dr. Tiao is involved in the care of children afflicted with biliary atresia from the time of presentation and diagnosis to the initial Kasai portoenterostomy to the liver transplant, when necessary. He sees the many challenges children and their families experience when diagnosed with this life threatening disease process. From that perspective, defining the basis of this disease process such that therapeutic strategies can be developed eliminating these complex interventions is his career goal. His short term goal is to develop an independent research laboratory investigating the pathogenesis of virus induced biliary atresia specifically seeking to determine the mechanistic basis of this disease so that new treatment strategies can be developed to salvage the native liver.

Dr. Tiao's overarching hypothesis is that biliary atresia results from the infection of cholangiocytes by a virus triggering immune-mediated biliary obstruction. His focus is to determine the mechanisms used by RRV to infect cholangiocytes, how RRV undergoes replication within the cholangiocyte, and how infected cholangiocytes modify the microenvironment, activating the immune system resulting in biliary obstruction. Determination of the mechanistic basis of these inter-related events is essential to understanding the pathogenesis of virus induced BA. By focusing on the basis for the viral insult in the initiation of biliary atresia, he has defined an area of independence from Dr Jorge Bezerra, his primary research mentor.

Education and Training

BS: Northwestern University, Evanston, IL, 1986.

MD: University of Illinois, Chicago, IL, 1990.

Residency: Loyola University, Maywood, IL, 1991-1992; Senior Resident, Department of Surgery, University of Cincinnati, Cincinnati, OH, 1995-1997;Chief Resident, Department of Surgery, University of Cincinnati, Cincinnati, OH, 1997-1998.

Fellowships: Research Fellow, University of Cincinnati, Cincinnati, OH, 1992-1995; Transplant Surgery Fellow, University of Cincinnati, Cincinnati, OH, 2000-2002;Pediatric Surgery Fellow, Los Angeles Children's Hospital, Los Angeles, CA, 1998-2000.

Certification: Pediatric Surgeon, 2000; Transplant Surgeon, 2002.

Publications

Coots A, Donnelly B, Mohanty S, Tiao G. Rotavirus Infection of Human Cholangiocytes Parallels the Murine Model of Biliary Atresia. Journal of Surgical Research. Epub ahead of print. 2012.

Meyers RL, Tiao GM, Dunn SP, Langham Jr, MR. Liver transplantation in the management of unresectable hepatoblastoma in children. Frontiers in Bioscience. 2012 Jan;E4:1293-1302.

Fernandez KS, Baum R, Fung B, Yeager N, Leonis MA, Wagner LM, Tiao G, Ross ME. Chemoresistant Hepatoblastoma in a Patient with Mosaic Trisomy 18 Treated with Orthotopic Liver Transplantation. Peditr Blood Cancer. 2011;56:498-500.

Superina R, Magee J, Brandt M, Healey P, Tiao G, Ryckman F, Karrer F, Iyer K, Fecteau A, West K, Burns R, Flake A, Hammin L, Lowell J, Dillon P, Columbani P, Ricketts R, Yun L, Moore J, Kasper W. Childhood Liver Research and Education Network. AnnSurg. 2011.

Bondoc A, Taylor J, Alonso M, Nathan, J, Wang Y, Balistreri W, Bezerra J, Ryckman F, Tiao G. The Beneficial Impact of Revision of Kasai Portoenterostomy for Biliary Atresia: An Institutional Study. AnnSurg. 2012;255(3):570-6.

Wang W, Donnelly B, Bondoc A, Mohanty SK, McNeal M, Ward R, Sestak K, Zheng S, Tiao G. The rhesus rotavirus gene encoding VP4 is a major determinant in the pathogenesis of biliary atresia in newborn mice. J Virol. 2011 Jun.

Jafri M, Donnelly B, Bondoc A, Allen S, Tiao G. Cholangiocyte secretion of chemokines in experimental biliary atresia. J Pediatr Surg. 2009;44(3):500-7.

Bondoc AJ, Jafri MA, Donnelly B, Mohanty SK, McNeal MM, Ward, RL, Tiao GM. Prevention of the murine model of biliary atresia after live rotavirus vaccination of dams. J Pediatr Surg. 2009;44(8):1479-90.