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The Intestinal Care Center is home to specialists with a wide variety of backgrounds and areas of focus. As a team, this diversity makes us better prepared to care for your child’s unique needs. Learn more about our faculty and staff.
Maria H. Alonso, MD Surgical Director, Kidney Transplant Program 513-636-4371 email@example.com
Surgical Director, Kidney Transplant Program
Co-Surgical Director, Intestinal Transplant Surgery
Associate Professor, UC Department of Surgery
Liver, kidney transplantation; hepatobiliary surgery; minimally invasive surgery; trauma
MD: University of Pennsylvania School of Medicine, Philadelphia, PA, 1982.
Residency: Surgery, Eastern Virginia Graduate School of Medicine, Norfolk, VA.
Fellowship: Trauma / Critical Care, Maryland Institute for Emergency Medical Services Systems, Baltimore, MD; Trauma / Burn, Children's National Medical Center, Washington, D.C.; Pediatric Surgery, Children's Mercy Hospital, Kansas City, MO; Transplantation, University of Cincinnati College of Medicine, Cincinnati, OH.
Certification: Surgery, 1999; Pediatric Surgery, 2001; Surgical Critical Care, 2001.
Conrad R. Cole, MD, MPH, MSc Director, Intestinal Rehabilitation 513-636-4415 firstname.lastname@example.org
Director, Intestinal Rehabilitation
Associate Professor, UC Department of Pediatrics
Intestinal failure; short bowel syndrome; growth failure; failure to thrive malabsorption disorders; micronutrient malnutrition
Conrad Cole, MD, is an expert in the management of infants with intestinal failure and short bowel syndrome. He is an associate director of the Pediatric Nutrition and Intestinal Care Center in the Division of Gastroenterology, Hepatology and Nutrition. In addition, he is an associate professor of pediatrics at the University of Cincinnati College of Medicine.
Dr. Cole's research interest is in the epidemiology of intestinal failure and it's complications especially in identifying risk factors associated with worsening prognosis. He is also interested in micronutrient malnutrition specifically zinc and iron and how they impact other micronutrients in preschool children especially from low income minority populations.
Prior to joining Cincinnati Children's, Dr. Cole was at Emory University's Schools of Medicine and Public Health. Dr. Cole earned his medical degree from the University of Ibadan, and also completed graduate degrees in public health from Ohio State University and clinical research from Emory University. He received training in nutrition under the mentorship of Fima Lifshitz MD at Maimonides Medical Center and Miami Children's Hospital prior to completing an internship and residency in pediatrics at the Miami Children's Hospital; and a fellowship in pediatric gastroenterology at Cincinnati Children's Hospital Medical Center.
MD: University of Ibadan.
MPH: Ohio State University, Columbus, OH.
MSc: Emory University, Atlanta, GA.
Residency: Miami Children's Hospital, Miami, FL.
Fellowship: Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
Certification: Pediatrics, Pediatric Gastroenterology.
Cole CR, Grant FK, Swaby-Ellis ED, Smith JL, Jacques A, Northrop-Clewes CA, Caldwell KL, Pfeiffer CM, Ziegler TR. Zinc and iron deficiency and their interrelationship in low-income African American and Hispanic children in Atlanta. American Journal of Clinical Nutrition. 2010;91:1027-1034.
Cole CR, Grant FK, Tangpricha V, Swaby-Ellis ED, Smith JL, Jacques A, Chen HP, Schleicher RL, Ziegler TR. 25-hydroxyvitamin D status of healthy low-income minority children in Atlanta. Pediatrics. 2010;125: 633-639.
Cole C, Freitas A, Clifton MS, Durham MM. Hereditary Multiple Intestinal Atresias: two new cases and review of the literature. Journal of Pediatric Surgery. 2010;45:E21-24.
Frem J, Sarson Y. Sternberg T, Cole CR. Copper supplementation in parenteral nutrition of cholestatic infants. Journal of Pediatric Gastroenterology, Hepatology and Nutrition. 2010;50: 650-654.
Cole CR, Frem JC, Schmotzer B, Gewirtz AT, Meddings JB, Gold BD, Ziegler TR. The rate of bloodstream infection is high in infants with short bowel syndrome: Relationship with small bowel bacterial overgrowth, enteral feeding and inflammatory and immune responses. Journal of Pediatrics. 2010;156: 941-947.e1.
Frem, J, Gold B, Shehada B, Cole C. Reflux masquerader: Acute H. pylori infection in infants. Journal of Pediatric Gastroenterology & Nutrition. 2008;46:589-592.
Cole CR, Hansen N, Huggins R, Ziegler TR, Stoll BJ for the NICHD neonatal research network. Very low birth weight preterm infants with surgical short bowel syndrome: incidence, morbidity and mortality and growth outcomes at 18-22 months. Pediatrics. 2008;112:e573-582.
Sandra Cortina, PhD Pediatric Psychologist, Clinical, Behavioral Medicine & Clinical Psychology 513-636-4336 email@example.com
Pediatric Psychologist, Clinical, Behavioral Medicine & Clinical Psychology
Center for Adherence and Self-Management
Assistant Professor, UC Department of Pediatrics
Sandra Cortina, PhD, is an assistant professor of pediatrics in the Division of Behavioral Medicine and Clinical Psychology. She currently serves as a clinical faculty member and director of clinical service for the Center for the Promotion of Treatment Adherence and Self-Management.
Dr. Cortina provides leadership in the integration of clinical care and research as part of the center’s innovative clinical effectiveness program. She provides out-patient treatment to patients and families coping with a variety of chronic pediatric illness conditions. She specializes in adherence to medical treatment, behavioral concerns, and general psychosocial adjustment of patients and families. Specific out-patient services include providing cognitive behavioral and parent training strategies, follow-up of patient adjustment to new diagnosis, and utilizing motivational interviewing techniques.
Dr. Cortina also serves as a consultant to a multi-site, randomized control trial of an intervention to promote adherence to oral medication among adolescents with acute lymphoblastic leukemia, as well as an intervention to promote adherence among young adults with lupus. Finally, she is involved with Dr. Drotar in the development of several manuscripts pertaining to patient and family adjustment to chronic illness, as well as behavioral adherence to medical treatment.
BA: Psychology, Trinity University, 2000.
PhD: Counseling Psychology, University of Iowa, 2007.
Internship/Residency: Children’s Hospital of Michigan, 2005.
Fellowship: Rainbow Babies and Children’s Hospital, 2006; Cincinnati Children's Hospital Medical Center, 2007
Cortina SD, Drotar D, Ericksen M, Lindsey M, Patterson TL, Biagini Myers JM, Kovacic MB, Khurana Hershey GK. Genetic Biomarkers of Health-Related Quality of Life in Pediatric Asthma. J Pediatr. 2011 Feb 14.
Cortina S, McGraw K, Dealarcon A, Ahrens A, Rothenberg ME, Drotar D. Psychological Functioning of Children and Adolescents With Eosinophil-Associated Gastrointestinal Disorders. Child Health Care. 2010 Oct;39(4):266-278.
Herzer M, Goebel J, Cortina S. Transitioning cognitively impaired young patients with special health needs to adult-oriented care: collaboration between medical providers and pediatric psychologists. Curr Opin Pediatr. 2010 Oct;22(5):668-72.
Cortina S, Repaske DR, Hood KK. Sociodemographic and psychosocial factors associated with continuous subcutaneous insulin infusion in adolescents with type 1 diabetes. Pediatr Diabetes. 2010 Aug;11(5):337-44.
Michael K. Farrell, MD Chief-of-Staff 513-636-4415 firstname.lastname@example.org
Professor, UC Department of Pediatrics
MD: Jefferson Medical College, Philadelphia, PA, 1970.
Internship: Harrisburg Polyclinic Hospital, Harrisburg, PA, 1970 to 1971.
Residency: Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 1974 to 1976.
Fellowship: Ambulatory Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 1976 to 1977.
Fellowship: Pediatric Gastroenterology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 1977 to 1979.
Britto MT, Byczkowski TL, Anneken AM, Hausfeld J, Schoettker PJ, Farrell MK, Kotagal UR. Improving access to pediatric subspecialty care: initial failures and lessons learned. Qual Manag Health Care. 2008 Oct-Dec;17(4):320-9.
Stehr W, Farrell MK, Lucky AW, Johnson ND, Racadio JM, Azizkhan RG. Non-endoscopic percutaneous gastrostomy placement in children with recessive dystrophic epidermolysis bullosa. Pediatr Surg Int. 2008 Mar;24(3):349-54.
Azizkhan RG, Stehr W, Cohen AP, Wittkugel E, Farrell MK, Lucky AW, Hammelman BD, Johnson ND, Racadio JM. Esophageal strictures in children with recessive dystrophic epidermolysis bullosa: an 11-year experience with fluoroscopically guided balloon dilatation. J Pediatr Surg. 2006 Jan;41(1):55-60; discussion 55-60.
Noel RJ, Miles L, Putnam PE, Farrell MK. Clinical quiz: rectal prolapse. J Pediatr Gastroenterol Nutr. 2004 Nov;39(5):567, 575.
Pohl JF, Hughes C, Farrell MK. Pathology teach and tell: chronic-onset hereditary tyrosinemia type I. Pediatr Pathol Mol Med. 2001 May-Jun;20(3):241-4.
Perlstein PH, Kotagal UR, Schoettker PJ, Atherton HD, Farrell MK, Gerhardt WE, Alfaro MP. Sustaining the implementation of an evidence-based guideline for bronchiolitis. Arch Pediatr Adolesc Med. 2000 Oct;154(10):1001-7.
Perlstein PH, Kotagal UR, Bolling C, Steele R, Schoettker PJ, Atherton HD, Farrell MK. Evaluation of an evidence-based guideline for bronchiolitis. Pediatrics. 1999 Dec;104(6):1334-41.
Pohl JF, Murarka P, Farrell MK, Bezerra J. Insights. Pylephlebitis. J Pediatr. 1999 Oct;135(4):529.
Dellert SF, Farrell MK, Specker BL, Heubi JE. Bone mineral content in children with short bowel syndrome after discontinuation of parental nutrition. J Pediatr. 1998 Mar;132(3 Pt 1):516-9.
Dellert SF, Nowicki MJ, Farrell MK, Delente J, Heubi JE. The 13C-xylose breath test for the diagnosis of small bowel bacterial overgrowth in children. J Pediatr Gastroenterol Nutr. 1997 Aug;25(2):153-8.
Michael A. Helmrath, MD, MS Surgical Director, Intestinal Rehabilitation Program 513-636-3240 email@example.com
Surgical Director, Intestinal Rehabilitation Program
Director of Surgical Research
Pediatric Surgeon, Peña Colorectal Center
Professor, UC Department of Surgery
As a pediatric surgeon, Dr. Helmrath has dedicated his career to the care of patients with intestinal failure. The main focus of his laboratory is directed towards characterizing intestinal stem cells during intestinal adaptation and developing intestinal regenerative strategies. By combining his clinical experience as the surgical director of intestinal research and rehabilitation at Cincinnati Children’s, his long-term goal is to establish translational therapies for the management of patients with short bowel syndrome.
BA: Miami University, Oxford, OH, 1987.
MD: University of Cincinnati College of Medicine, Cincinnati, OH, 1993.
MS: University of Cincinnati College of Medicine, Cincinnati, OH, 1989.
Certification: Board-certified General Surgery; board-certified, Pediatric Surgery.
Michalsky MP, Inge TH, Teich S, Eneli I, Miller R, Brandt ML, Helmrath M, Harmon CM, Zeller MH, Jenkins TM, Courcoulas A, Buncher RC; Teen-LABS Consortium. Adolescent bariatric surgery program characteristics: The Teen Longitudinal Assessment of Bariatric Surgery (Teen-LABS) study experience. Semin Pediatr Surg. 2014 Feb;23(1):5-10.
Inge TH, Zeller MH, Jenkins TM, Helmrath M, Brandt ML, Michalsky MP, Harmon CM, Courcoulas A, Horlick M, Xanthakos SA, Dolan L, Mitsnefes M, Barnett SJ, Buncher R; Teen-LABS Consortium. Perioperative outcomes of adolescents undergoing bariatric surgery: the Teen-Longitudinal Assessment of Bariatric Surgery (Teen-LABS) study. JAMA Pediatr. 2014 Jan;168(1):47-53.
Ubesie AC, Kocoshis SA, Mezoff AG, Henderson CJ, Helmrath MA, Cole CR. Multiple micronutrient deficiencies among patients with intestinal failure during and after transition to enteral nutrition. J Pediatr. 2013 Dec;163(6):1692-6.
Eradi B, Hamrick M, Bischoff A, Frischer JS, Helmrath M, Hall J, Pena A, Levitt MA. The role of a colon resection in combination with a Malone appendicostomy as part of a bowel management program for the treatment of fecal incontinence. J Pediatr Surg. 2013 Nov; 48(11):2296-300.
Fuller MK, Faulk DM, Sundaram N, Mahe MM, Stout KM, von Furstenberg RJ, Smith BJ, McNaughton KK, Shroyer NF, Helmrath MA, Henning SJ. Intestinal stem cells remain viable after prolonged tissue storage. Cell Tissue Res. 2013 Nov;354(2):441-50.
Devine AA, Gonzalez A, Speck KE, Knight R, Helmrath M, Lund PK, Azcarate-Peril MA. Impact of ileocecal resection and concomitant antibiotics on the microbiome of the murine jejunum and colon. PLoS One. 2013; 8(8):e73140.
Fuller MK, Faulk DM, Sundaram N, Shroyer NF, Henning SJ, Helmrath MA. Intestinal crypts reproducibly expand in culture. J Surg Res. 2012 Nov;178(1):48-54.
Stelzner M, Helmrath M, Dunn JC, Henning SJ, Houchen CW, Kuo C, Lynch J, Li L, Magness ST, Martin MG, Wong MH, Yu J; NIH Intestinal Stem Cell Consortium. A nomenclature for intestinal in vitro cultures. Am J Physiol Gastrointest Liver Physiol. 2012 Jun 15;302(12):G1359-63.
Van Landeghem L, Blue RE, Dehmer JJ, Henning SJ, Helmrath MA, Lund PK. Localized intestinal radiation and liquid diet enhance survival and permit evaluation of long-term intestinal responses to high dose radiation in mice. PLoS One. 2012;7(12):e51310.
Adolescent Bariatrics: Assessing Health Benefits & Risk. Co-investigator. National Institute of Diabetes and Digestive and Kidney Diseases. Nov 2011 – Oct 2016. U01 DK072493.
Human Endocrine Cell Development. Co-investigator. National Institute of Diabetes and Digestive and Kidney Diseases. Apr 2012 – Mar 2017. R01 DK092456.
Samuel A. Kocoshis, MD Medical Director, Intestinal Care Center 513-636-4415 firstname.lastname@example.org
Medical Director, Intestinal Care Center
Medical Director, Small Bowel Transplantation Program
Management of complex intestinal and liver disease; small bowel transplantation; general disorders of the gastrointestinal tract
Samuel Kocoshis, MD, is an expert in the management of complex intestinal and liver disease at Cincinnati Children's Hospital Medical Center.
Dr. Kocoshis is the director of the Pediatric Nutrition and Intestinal Care Center in the Division of Gastroenterology, Hepatology and Nutrition, and is also the medical director of the Small Intestinal Transplantation Program. In addition, he is professor of pediatrics at the University of Cincinnati College of Medicine.
Dr. Kocoshis' long-standing research interest has been altered bile acid metabolism in gastrointestinal disease. His current clinical research program focuses upon intestinal adaptation following massive small intestinal resection, as well as the immunology of intestinal transplantation.
Prior to joining Cincinnati Children's, Dr. Kocoshis was chief of Pediatric Gastroenterology and co-director of the Intestinal Care Center at Children's Hospital of Pittsburgh, and professor of pediatrics at the University of Pittsburgh School of Medicine.
Dr. Kocoshis earned his bachelor's degree from DePauw University and his medical degree from the Medical College of Wisconsin. He completed an internship in pediatrics at the West Virginia University Medical Center; a residency in pediatrics at Children's Hospital of Pittsburgh; and a clinical fellowship in gastroenterology at Yale University School of Medicine.
BS: DePauw University, Greencastle, IN.
MD: Medical College of Wisconsin, Milwaukee, WI.
Residency: Children's Hospital of Pittsburgh, Pittsburgh, PA.
Fellowship: Yale University School of Medicine, New Haven, CT.
Kocoshis SA. Medical management of pediatric intestinal failure. Semin Pediatr Surg. 2010 Feb;19(1):20-6. Review.
Wessel JJ, Kocoshis SA. Nutritional management of infants with short bowel syndrome. Semin Perinatol. 2007 Apr;31(2):104-11. Review.
Nathan JD, Rudolph JA, Kocoshis SA, Alonso MH, Ryckman FC, Tiao GM. Isolated liver and multivisceral transplantation for total parenteral nutrition-related end-stage liver disease. J Pediatr Surg. 2007 Jan;42(1):143-7.
Kocoshis S. Small Intestinal Failure in Children. Curr Treat Options Gastroenterol. 2001 Oct;4(5):423-432.
Jaimie D. Nathan, MD Surgical Director, Intestinal Transplant Program 513-636-4371 email@example.com
Surgical Director, Intestinal Transplant Program
Surgical Director, Pancreas Care Center
Assistant Professor, UC Department of Surgery
UC Department of Pediatrics
Hepatobiliary and pancreatic disease; liver, kidney, and intestinal transplantation; pediatric surgical oncology; neonatal surgery; minimally invasive surgery
BS: Yale University, New Haven, CT, 1993.
MD: Yale University, New Haven, CT, 1998.
Residency: General Surgery, Duke University Medical Center, Durham, NC, 1998-2000 and 2002-2005.
Surgical Research Fellowship: Duke University Medical Center, Durham, NC, 2000-2002.
Pediatric Surgery Fellowship: Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2005-2007.
Transplant Surgery Fellowship: University of Cincinnati, Cincinnati, OH, 2007-2009.
Certification: American Board of Surgery, General Surgery, 2007; American Board of Surgery, Pediatric Surgery, 2008; American Society of Transplant Surgeons Certification, 2009.
Prada CE, Kaul A, Hopkin RJ, Page KI, Nathan JD, Bartholomew DW, Cohen MB, Heubi JE, Leslie ND, Burrow TA. Recurrent pancreatitis in ornithine transcarbamylase deficiency. Mol Genet Metab. 2012 Aug;106(4):482-484.
Bondoc AJ, Taylor JA, Alonso MH, Nathan JD, Wang Y, Balistreri WF, Bezerra JA, Ryckman FC, Tiao GM. The beneficial impact of revision of Kasai portoenterostomy for biliary atresia: an institutional study. Ann Surg. 2012 Mar;255(3):570-576.
Shin CR, Nathan J, Alonso M, Yazigi N, Kocoshis S, Tiao G, Davies SM. Incidence of acute and chronic graft-versus-host disease and donor T-cell chimerism after small bowel or combined organ transplantation. J Pediatr Surg. 2011 Sep;46(9):1732-1738.
Vigna SR, Shahid RA, Nathan JD, McVey DC, Liddle RA. Leukotriene B4 mediates inflammation via TRPV1 in duct obstruction-induced pancreatitis in rats. Pancreas. 2011 Jul;40(5):708-714.
Nathan JD, Romac J, Peng RY, Peyton M, Rockey DC, Liddle RA. Protection against chronic pancreatitis and pancreatic fibrosis in mice overexpressing pancreatic secretory trypsin inhibitor. Pancreas. 2010 Jan;39(1):e24-30.
Ryckman FC, Bucuvalas JC, Nathan J, Alonso M, Tiao G, Balistreri WF. Outcomes following liver transplantation. Semin Pediatr Surg. 2008 May;17(2):123-30.
Follmar KE, Condron SA, Turner II, Nathan JD, Ludwig KA. Treatment of metronidazole-refractory Clostridium difficile enteritis with vancomycin. Surg Infect. 2008 9:195-200.
Patel MB, Nathan JD, Frush DP, Rice HE. Nonoperative management of asymptomatic traumatic pulmonary hernia in a young child. J Trauma. 2007 62:234-235.
Nathan JD, Romac J, Peng RY, Peyton M, MacDonald RJ, Liddle RA. Transgenic expression of pancreatic secretory trypsin inhibitor-I ameliorates secretagogue-induced pancreatitis in mice. Gastroenterology. 2005 128:717-727.
Frederick C. Ryckman, MD Sr. Vice President, Medical Operations 513-636-4371 firstname.lastname@example.org
Sr. Vice President, Medical Operations
UC Department of Surgery
Transplantation; liver; kidney transplantation; small intestine; biliary disease; Extracorporeal membrane oxygenation (ECMO); minimally invasive surgery; chest wall abnormalities
Frederick C. Ryckman, MD, is clinical director of the Pediatric General and Thoracic Surgery Division.
Dr. Ryckman is also vice president of System Capacity & Perioperative Operations.
Dr. Ryckman is also a pediatric surgeon at the Cincinnati Fetal Center.
BS: Lyman Briggs College of Science and Mathematics, Michigan State University, East Lansing, MI, 1969 to 1973.
MD: University of Michigan Medical School, Ann Arbor, MI, 1977.
Residency: University of Florida Medical Center, Gainesville, FL, 1977 to 1982.
Fellowship: Pediatric Surgery, Children's Hospital Medical Center, Cincinnati, OH, 1982 to 1984.
Certification: National Board of Medical Examiners, 1977; American Board of Surgery, 1983; recertification, 1993; Certificate of Special Competence in Pediatric Surgery, 1986; recertification, 1993.
Wagner LM, Gelfand MJ, Laor T, Ryckman FC, Al-Ghawi H, Bove KE. A Welcome Surprise: Nodular Fasciitis Presenting as Soft Tissue Sarcoma. J Pediatr Hematol Oncol. 2010 Oct 21.
Taylor JA, Ryckman FC. Management of small bowel volvulus around feeding Roux-en-Y limbs. Pediatr Surg Int. 2010 Apr;26(4):439-42.
Ryckman FC, Yelton PA, Anneken AM, Kiessling PE, Schoettker PJ, Kotagal UR. Redesigning intensive care unit flow using variability management to improve access and safety. Jt Comm J Qual Patient Saf. 2009 Nov;35(11):535-43.
Rattan AS, Laor T, Ryckman FC, Brody AS. Pectus excavatum imaging: enough but not too much. Pediatr Radiol. 2010 Feb;40(2):168-72.
Propst EJ, Lin EP, Istaphanous GK, Boesch RP, Ryckman FC, Cotton RT, Rutter MJ. Management of traumatic tracheobronchial separation in a teenager using a fabricated extra-long endotracheal tube. Int J Pediatr Otorhinolaryngol. 2009 Aug;73(8):1163-7.
Ryckman FC, Schoettker PJ, Hays KR, Connelly BL, Blacklidge RL, Bedinghaus CA, Sorter ML, Friend LC, Kotagal UR. Reducing surgical site infections at a pediatric academic medical center. Jt Comm J Qual Patient Saf. 2009 Apr;35(4):192-8.
Dickie B, Dasgupta R, Nair R, Alonso MH, Ryckman FC, Tiao GM, Adams DM, Azizkhan RG. Spectrum of hepatic hemangiomas: management and outcome. J Pediatr Surg. 2009 Jan;44(1):125-33.
Sparling KW, Ryckman FC, Schoettker PJ, Byczkowski TL, Helpling A, Mandel K, Panchanathan A, Kotagal UR. Financial impact of failing to prevent surgical site infections. Qual Manag Health Care. 2007 Jul-Sep;16(3):219-25.
Nathan JD, Rudolph JA, Kocoshis SA, Alonso MH, Ryckman FC, Tiao GM. Isolated liver and multivisceral transplantation for total parenteral nutrition-related end-stage liver disease. J Pediatr Surg. 2007 Jan;42(1):143-7.
Greg M. Tiao, MD Richard and Geralyn Azizkhan Chair in Pediatric Surgery 513-636-4371 email@example.com
Richard and Geralyn Azizkhan Chair in Pediatric Surgery
Surgical Director, Liver Transplantation
Associate Director, Pediatric Surgery Fellowship
As a pediatric surgeon and a transplant surgeon, Dr. Tiao is involved in the care of children afflicted with biliary atresia from the time of presentation and diagnosis to the initial Kasai portoenterostomy to the liver transplant, when necessary. He sees the many challenges children and their families experience when diagnosed with this life threatening disease process. From that perspective, defining the basis of this disease process such that therapeutic strategies can be developed eliminating these complex interventions is his career goal. His short term goal is to develop an independent research laboratory investigating the pathogenesis of virus induced biliary atresia specifically seeking to determine the mechanistic basis of this disease so that new treatment strategies can be developed to salvage the native liver.
Dr. Tiao's overarching hypothesis is that biliary atresia results from the infection of cholangiocytes by a virus triggering immune-mediated biliary obstruction. His focus is to determine the mechanisms used by RRV to infect cholangiocytes, how RRV undergoes replication within the cholangiocyte, and how infected cholangiocytes modify the microenvironment, activating the immune system resulting in biliary obstruction. Determination of the mechanistic basis of these inter-related events is essential to understanding the pathogenesis of virus induced BA. By focusing on the basis for the viral insult in the initiation of biliary atresia, he has defined an area of independence from Dr Jorge Bezerra, his primary research mentor.
BS: Northwestern University, Evanston, IL, 1986.
MD: University of Illinois, Chicago, IL, 1990.
Residency: Loyola University, Maywood, IL, 1991-1992; Senior Resident, Department of Surgery, University of Cincinnati, Cincinnati, OH, 1995-1997;Chief Resident, Department of Surgery, University of Cincinnati, Cincinnati, OH, 1997-1998.
Fellowships: Research Fellow, University of Cincinnati, Cincinnati, OH, 1992-1995; Transplant Surgery Fellow, University of Cincinnati, Cincinnati, OH, 2000-2002;Pediatric Surgery Fellow, Los Angeles Children's Hospital, Los Angeles, CA, 1998-2000.
Certification: Pediatric Surgeon, 2000; Transplant Surgeon, 2002.
Coots A, Donnelly B, Mohanty S, Tiao G. Rotavirus Infection of Human Cholangiocytes Parallels the Murine Model of Biliary Atresia. J Surg Res. 2012 Oct;177(2):275-81. 2012.
Meyers RL, Tiao GM, Dunn SP, Langham Jr, MR. Liver transplantation in the management of unresectable hepatoblastoma in children. Front Biosci (Elite Ed). 2012 Jan;E4:1293-302.
Shin CR, Nathan J, Alonso M, Yazigi N, Kocoshis S, Tiao G, Davies SM. Incidence of acute and chronic graft-versus-host disease and donor T-cell chimerism after small bowel or combined organ transplantation. J Pediatr Surg. 2011;46:1732-8.
Fernandez KS, Baum R, Fung B, Yeager N, Leonis MA, Wagner LM, Tiao G, Ross ME. Chemoresistant Hepatoblastoma in a Patient with Mosaic Trisomy 18 Treated with Orthotopic Liver Transplantation. Peditr Blood Cancer. 2011;56:498-500.
Superina R, Magee J, Brandt M, Healey P, Tiao G, Ryckman F, Karrer F, Iyer K, Fecteau A, West K, Burns R, Flake A, Hammin L, Lowell J, Dillon P, Columbani P, Ricketts R, Yun L, Moore J, Kasper W. Childhood Liver Research and Education Network. AnnSurg. 2011.
Bondoc A, Taylor J, Alonso M, Nathan, J, Wang Y, Balistreri W, Bezerra J, Ryckman F, Tiao G. The Beneficial Impact of Revision of Kasai Portoenterostomy for Biliary Atresia: An Institutional Study. AnnSurg. 2012;255(3):570-6.
Wang W, Donnelly B, Bondoc A, Mohanty SK, McNeal M, Ward R, Sestak K, Zheng S, Tiao G. The rhesus rotavirus gene encoding VP4 is a major determinant in the pathogenesis of biliary atresia in newborn mice. J Virol. 2011 Sep;85(17):9069-77.
Jafri M, Donnelly B, Bondoc A, Allen S, Tiao G. Cholangiocyte secretion of chemokines in experimental biliary atresia. J Pediatr Surg. 2009;44(3):500-7.
Bondoc AJ, Jafri MA, Donnelly B, Mohanty SK, McNeal MM, Ward, RL, Tiao GM. Prevention of the murine model of biliary atresia after live rotavirus vaccination of dams. J Pediatr Surg. 2009;44(8):1479-90.
The Molecular Determinants of Virus Induced Biliary Induced Biliary Asteria. Principal Investigator. Apr 2011 - Mar 2016.
Nycomed Liver Trial. Principal Investigator. 2012-present.TC-2402-040-SP.
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