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Medical / Surgical Team

Maria H. Alonso, MD
Surgical Director, Kidney Transplant Program

513-636-4371

maria.alonso@cchmc.org

Conrad R. Cole, MD, MPH, MSc

513-636-4415

conrad.cole@cchmc.org

High Res

Conrad R. Cole, MD, MPH, MSc

Associate Professor, UC Department of Pediatrics

Phone: 513-636-4415

Fax: 513-636-7805

Email: conrad.cole@cchmc.org

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Specialties

Clinical Interests

Intestinal failure; short bowel syndrome; growth failure; failure to thrive malabsorption disorders; micronutrient malnutrition

Research Interests

Nutritional and developmental outcomes of infants with intestinal failure and short bowel syndrome; nutritional epidemiology of micronutrient malnutrition in preschool children

Biography

Conrad Cole, MD, is an expert in the management of infants with intestinal failure and short bowel syndrome. He is an Associate Director of the Pediatric Nutrition and Intestinal Care Center in the Pediatric Gastroenterology, Hepatology and Nutrition Division. In addition, he is an Associate Professor of Pediatrics at the University of Cincinnati College of Medicine.

Dr. Cole's research interest is in the epidemiologyy of intestinal failure and it's complications especially in identifying risk factors associated with worsening prognosis. He is also interested in micronutrient malnutrition specifically zinc and iron and how they impact other micronutrients in preschool children especially from low income minority populations.

Prior to joining Cincinnati Children's, Dr. Cole was at Emory University's Schools of Medicine and Public Health. Dr. Cole earned his medical degree from the University of Ibadan, and also completed graduate degrees in public health from Ohio State University and clinical research from Emory University. He received training in nutrition under the mentorship of Fima Lifshitz MD at Maimonides Medical Center and Miami Children's Hospital prior to completing an internship and residency in Pediatrics at the Miami Children's Hospital; and a fellowship in Pediatric Gastroenterology at Cincinnati Children's Hospital Medical Center.

Education and Training

MD: University of Ibadan

MPH: Ohio State University, Columbus, OH

MSc: Emory University, Atlanta, GA

Resdency: Miami Children's Hospital, Miami, FL

Fellowship: Cincinnati Children's Hospital Medical Center, Cincinnati, OH

Certification: Pediatrics, Pediatric Gastroenterology

Publications

View PubMed Publications

Cole CR, Grant FK, Swaby-Ellis ED, Smith JL, Jacques A, Northrop-Clewes CA, Caldwell KL, Pfeiffer CM and Ziegler TR. Zinc and iron deficiency and their interrelationship in low-income African American and Hispanic children in Atlanta. American Journal of Clinical Nutrition. 2010;91:1027-1034.

Cole CR, Grant FK, Tangpricha V, Swaby-Ellis ED, Smith JL, Jacques A, Chen HP, Schleicher RL, Ziegler TR. 25-hydroxyvitamin D status of healthy low-income minority children in Atlanta. Pediatrics. 2010;125: 633-639.

Cole C, Freitas A, Clifton MS and Durham MM. Hereditary Multiple Intestinal Atresias: two new cases and review of the literature. Journal of Pediatric Surgery. 2010;45:E21-24.

Frem J, Sarson Y. Sternberg T and Cole CR. Copper supplementation in parenteral nutrition of cholestatic infants. Journal of Pediatric Gastroenterology, Hepatology and Nutrition. 2010;50: 650-654.

Cole CR, Frem JC, Schmotzer B, Gewirtz AT, Meddings JB, Gold BD and Ziegler TR. The rate of bloodstream infection is high in infants with short bowel syndrome: Relationship with small bowel bacterial overgrowth, enteral feeding and inflammatory and immune responses. Journal of Pediatrics. 2010;156: 941-947.e1.

Frem, J, Gold B, Shehada B, Cole C. Refux masquerader: Acute H. pylori infection in infants. Journal of Pediatric Gastroenterology & Nutrition. 2008;46:589-592.

Cole CR, Hansen N, Huggins R, Ziegler TR and Stoll BJ for the NICHD neonatal research network. Very low birth weight preterm infants with surgical short bowel syndrome: incidence, morbidity and mortality and growth outcomes at 18-22 months. Pediatrics. 2008;112:e573-582.

Michael K. Farrell, MD
Chief-of-Staff

513-636-4415

michael.farrell@cchmc.org

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Michael K. Farrell, MD

Chief-of-Staff

Professor, UC Department of Pediatrics

Phone: 513-636-4415

Fax: 513-636-7805

Email: michael.farrell@cchmc.org

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Specialties

Gastroesophageal reflux; pancreatitis; inflammatory bowel disease; abdominal pain; pediatric nutrition

Education and Training

MD: Jefferson Medical College, Philadelphia, PA, 1970.

Internship: Harrisburg Polyclinic Hospital, Harrisburg, PA, 1970 to 1971.

Residency: Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 1974 to 1976.

Fellowship: Ambulatory Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 1976 to 1977.

Fellowship: Pediatric Gastroenterology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 1977 to 1979.

Publications

View PubMed Publications

Britto MT, Byczkowski TL, Anneken AM, Hausfeld J, Schoettker PJ, Farrell MK, Kotagal UR. Improving access to pediatric subspecialty care: initial failures and lessons learned. Qual Manag Health Care. 2008 Oct-Dec;17(4):320-9.

Stehr W, Farrell MK, Lucky AW, Johnson ND, Racadio JM, Azizkhan RG. Non-endoscopic percutaneous gastrostomy placement in children with recessive dystrophic epidermolysis bullosa. Pediatr Surg Int. 2008 Mar;24(3):349-54.

Azizkhan RG, Stehr W, Cohen AP, Wittkugel E, Farrell MK, Lucky AW, Hammelman BD, Johnson ND, Racadio JM. Esophageal strictures in children with recessive dystrophic epidermolysis bullosa: an 11-year experience with fluoroscopically guided balloon dilatation. J Pediatr Surg. 2006 Jan;41(1):55-60; discussion 55-60.

Noel RJ, Miles L, Putnam PE, Farrell MK. Clinical quiz: rectal prolapse. J Pediatr Gastroenterol Nutr. 2004 Nov;39(5):567, 575.

Pohl JF, Hughes C, Farrell MK. Pathology teach and tell: chronic-onset hereditary tyrosinemia type I. Pediatr Pathol Mol Med. 2001 May-Jun;20(3):241-4.

Perlstein PH, Kotagal UR, Schoettker PJ, Atherton HD, Farrell MK, Gerhardt WE, Alfaro MP. Sustaining the implementation of an evidence-based guideline for bronchiolitis. Arch Pediatr Adolesc Med. 2000 Oct;154(10):1001-7.

Perlstein PH, Kotagal UR, Bolling C, Steele R, Schoettker PJ, Atherton HD, Farrell MK. Evaluation of an evidence-based guideline for bronchiolitis. Pediatrics. 1999 Dec;104(6):1334-41.

Pohl JF, Murarka P, Farrell MK, Bezerra J. Insights. Pylephlebitis. J Pediatr. 1999 Oct;135(4):529.

Dellert SF, Farrell MK, Specker BL, Heubi JE. Bone mineral content in children with short bowel syndrome after discontinuation of parental nutrition. J Pediatr. 1998 Mar;132(3 Pt 1):516-9.

Dellert SF, Nowicki MJ, Farrell MK, Delente J, Heubi JE. The 13C-xylose breath test for the diagnosis of small bowel bacterial overgrowth in children. J Pediatr Gastroenterol Nutr. 1997 Aug;25(2):153-8.

Michael A. Helmrath, MD, MS
Surgical Director, Intestinal Rehabilitation Center

513-636-4371

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Michael A. Helmrath, MD, MS

Surgical Director, Intestinal Rehabilitation Center

Professor, Division of Pediatric Surgery

Phone: 513-636-4371

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Education and Training

BA: Miami University, 1987.

MD: University of Cincinnati College of Medicine, 1993.

MS: University of Cincinnati College of Medicine, 1989.

Publications

View PubMed Publications

Inge TH, Miyano G, Bean J, Helmrath M, Courcoulas A, Harmon CM, Chen MK, Wilson K, Daniels SR, Garcia VF, Brandt ML, Dolan LM. Reversal of type 2 diabetes mellitus and improvements in cardiovascular risk factors after surgical weight loss in adolescents. Pediatrics. 2009 Jan;123(1):214-22.

Inge T, Helmrath M, Vierra M, Ikramuddin S. Challenges of adolescent bariatric surgery: tips for managing the extremely obese teen. J Laparoendosc Adv Surg Tech A. 2008 Feb;18(1):157-69.

Inge TH, Krebs NF, Garcia VF, Skelton JA, Guice KS, Strauss RS, Albanese CT, Brandt ML, Hammer LD, Harmon CM, Kane TD, Klish WJ, Oldham KT, Rudolph CD, Helmrath MA, Donovan E, Daniels SR. Bariatric surgery for severely overweight adolescents: concerns and recommendations. Pediatrics. 2004 Jul;114(1):217-23. Review.

Fridriksson JH, Helmrath MA, Wessel JJ, Warner BW. Hypercalcemia associated with extracorporeal life support in neonates. J Pediatr Surg. 2001 Mar;36(3):493-7.

Erwin CR, Helmrath MA, Shin CE, Falcone RA Jr, Stern LE, Warner BW. Intestinal overexpression of EGF in transgenic mice enhances adaptation after small bowel resection. Am J Physiol. 1999 Sep;277(3 Pt 1):G533-40.

Helmrath MA, Erwin CR, Shin CE, Warner BW. Enterocyte apoptosis is increased following small bowel resection. J Gastrointest Surg. 1998 Jan-Feb;2(1):44-9.

Helmrath MA, Shin CE, Fox JW, Erwin CR, Warner BW. Adaptation after small bowel resection is attenuated by sialoadenectomy: the role for endogenous epidermal growth factor. Surgery. 1998 Nov;124(5):848-54.

Shin CE, Helmrath MA, Falcone RA Jr, Fox JW, Duane KR, Erwin CR, Warner BW. Epidermal growth factor augments adaptation following small bowel resection: optimal dosage, route, and timing of administration. J Surg Res. 1998 Jun;77(1):11-6.

Helmrath MA, Shin CE, Erwin CR, Warner BW. The EGF\EGF-receptor axis modulates enterocyte apoptosis during intestinal adaptation. J Surg Res. 1998 Jun;77(1):17-22.

Helmrath MA, Shin CE, Erwin CR, Warner BW. Intestinal adaptation is enhanced by epidermal growth factor independent of increased ileal epidermal growth factor receptor expression. J Pediatr Surg. 1998 Jul;33(7):980-4; discussion 984-5.

Grants

Mechanisms of intestinal stem cell expansion following resection. Principal Investigator. National Institute of Diabetes and Digestive and Kidney Disease. Jul 2009 - June 2014. #R01DK083325.

Collaborative approach to the study of intestinal epithelial stem cells. Co-investigator. National Institute of Diabetes and Digestive and Kidney Diseases. Sep 2009 - Aug 2014. #1U01DK085547.

Samuel A. Kocoshis, MD
Medical Director, Pediatric Nutrition and Intestinal Care Center

513-636-4415

samuel.kocoshis@cchmc.org

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Samuel A. Kocoshis, MD

Medical Director, Pediatric Nutrition and Intestinal Care Center

Medical Director, Small Bowel Transplantation Program

Professor, UC Department of Pediatrics

Phone: 513-636-4415

Fax: 513-636-7805

Email: samuel.kocoshis@cchmc.org

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Specialties

Clinical Interests

Management of complex intestinal and liver disease; small bowel transplantation; general disorders of the gastrointestinal tract

Research Interests

Altered bile acid metabolism in gastrointestinal disease; small bowel transplantation; inflammatory bowel disease; short bowel syndrome

Biography

Samuel Kocoshis, MD, is an expert in the management of complex intestinal and liver disease at Cincinnati Children's Hospital Medical Center.

Dr. Kocoshis is the director of the Pediatric Nutrition and Intestinal Care Center in the Pediatric Gastroenterology, Hepatology and Nutrition Division, and is also the medical director of the Small Intestinal Transplantation Program. In addition, he is professor of pediatrics at the University of Cincinnati College of Medicine.

Dr. Kocoshis' long-standing research interest has been altered bile acid metabolism in gastrointestinal disease. His current clinical research program focuses upon intestinal adaptation following massive small intestinal resection, as well as the immunology of intestinal transplantation.

Prior to joining Cincinnati Children's, Dr. Kocoshis was chief of Pediatric Gastroenterology and co-director of the Intestinal Care Center at Children's Hospital of Pittsburgh, and professor of pediatrics at the University of Pittsburgh School of Medicine.

Dr. Kocoshis earned his bachelor's degree from DePauw University and his medical degree from the Medical College of Wisconsin. He completed an internship in pediatrics at the West Virginia University Medical Center; a residency in pediatrics at Children's Hospital of Pittsburgh; and a clinical fellowship in gastroenterology at Yale University School of Medicine.

Education and Training

BS: DePauw University, Greencastle, IN.

MD: Medical College of Wisconsin, Milwaukee, WI.

Residency: Children's Hospital of Pittsburgh, Pittsburgh, PA.

Fellowship: Yale University School of Medicine, New Haven, CT.

Publications

View PubMed Publications

Kocoshis SA. Medical management of pediatric intestinal failure. Semin Pediatr Surg. 2010 Feb;19(1):20-6. Review.

Wessel JJ, Kocoshis SA. Nutritional management of infants with short bowel syndrome. Semin Perinatol. 2007 Apr;31(2):104-11. Review.

Nathan JD, Rudolph JA, Kocoshis SA, Alonso MH, Ryckman FC, Tiao GM. Isolated liver and multivisceral transplantation for total parenteral nutrition-related end-stage liver disease.J Pediatr Surg. 2007 Jan;42(1):143-7.

Kocoshis S. Small Intestinal Failure in Children. Curr Treat Options Gastroenterol. 2001 Oct;4(5):423-432.

Adam G. Mezoff, MD, CPE, AGAF

513-636-4415

adam.mezoff@cchmc.org

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Adam G. Mezoff, MD, CPE, AGAF

Professor, UC Department of Pediatrics

Phone: 513-636-4415

Fax: 513-636-7805

Email: adam.mezoff@cchmc.org

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Specialties

Short bowel syndrome; technology dependant children; general disorders of the GI tract; nutritional support

Biography

Dr. Mezoff’s undergraduate work was at Brown University in Providence Rhode Island; however, he received all his medical training in Cincinnati. He was a medical student and pediatric resident at Cincinnati Children's Hospital Medical Center from 1977-1984. After three years of active duty in the Air Force, Dr. Mezoff returned to Cincinnati to complete a pediatric GI fellowship from 1987-1990.

Dr. Mezoff re-joined the GI division as an attending physician and professor of pediatrics after 18 years of leading the creation and development of the pediatric gastroenterology program at Dayton Children's Hospital.

Dr. Mezoffs specialty work is with Dr. Kocoshis in the Pediatric Nutrition and Intestinal Care Center where he is the associate director. He maintains an active general GI practice at the Liberty township satellite office.

Education and Training

MD: University of Cincinnati College of Medicine, June, 1981.

Residency: Cincinnati Children’s Medical Center, June, 1984.

Fellowship: Cincinnati Children’s Medical Center, June, 1990.

Certifications: American Board of Pediatrics, June 22, 1986; Subspecialty Certification - Pediatric; Gastroenterology, November 2, 1990; Recertification - Pediatric Gastroenterology, May 24, 1997; Recertification - Pediatric Gastroenterology, April, 2004; Certified Physician Executive (CPE); Certifying Commission in Medical Management, October, 2005.

Publications

View PubMed Publications

Bischoff A, Gupta A, D'Mello S, Mezoff A, Podberesky D, Barnett S, Keswani S, Frischer JS. Crohn's disease limited to the appendix: a case report in a pediatric patient.Pediatr Surg Int. 2010 Nov;26(11):1125-8.

Stadler LP, Mezoff AG, Staat MA. Hepatitis B virus screening for internationally adopted children.Pediatrics. 2008 Dec;122(6):1223-8.

Cohen MB, Mezoff AG, Laney DW Jr, Bezerra JA, Beane BM, Drazner D, Baker R, Moran JR. Use of a single solution for oral rehydration and maintenance therapy of infants with diarrhea and mild to moderate dehydration.Pediatrics. 1995 May;95(5):639-45.

Mezoff AG, Giannella RA, Eade MN, Cohen MB. Escherichia coli enterotoxin (STa) binds to receptors, stimulates guanyl cyclase, and impairs absorption in rat colon.Gastroenterology. 1992 Mar;102(3):816-22.

Mezoff AG, Jensen NJ, Cohen MB. Mechanisms of increased susceptibility of immature and weaned pigs to Escherichia coli heat-stable enterotoxin. Pediatr Res. 1991 May;29(5):424-8.

Mezoff AG, Cohen MB, Maisel SK, Farrell MK. Crohn disease in an infant with central nervous system thrombosis and protein-losing enteropathy.J Pediatr. 1990 Sep;117(3):436-9. Review.

Mezoff AG, Gremse DA, Farrell MK. Hypophosphatemia in the nutritional recovery syndrome. Am J Dis Child. 1989 Sep;143(9):1111-2.

Jaimie D. Nathan, MD
Pediatric Surgeon

513-636-4371

jaimie.nathan@cchmc.org

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Jaimie D. Nathan, MD

Pediatric Surgeon

Assistant Professor, Division of Pediatric Surgery

Phone: 513-636-4371

Fax: 513-636-7657

Email: jaimie.nathan@cchmc.org

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Specialties

Hepatobiliary and pancreatic disease; liver, kidney, and intestinal transplantation; neonatal surgery; minimally invasive surgery

Education and Training

MD: Yale University, New Haven, Connecticut, 1998.

Residency: Intern, General Surgery, Duke University Medical Center, Durham, North Carolina, 1998 - 1999; Junior Assistant Resident, General Surgery, Duke University Medical Center, Durham, North Carolina, 1999 - 2000; Senior Assistant Resident, General Surgery, Duke University Medical Center, Durham, North Carolina, 2002 - 2004; Chief Resident, General Surgery, Duke University Medical Center, Durham, North Carolina, 2004 - 2005.

Fellowships: Surgical Research Fellowship, Duke University Medical Center, Durham, North Carolina, 2000 - 2002; Pediatric Surgery Fellowship, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, 2005 - 2007; Transplant Surgery Fellowship, University of Cincinnati, Cincinnati, Ohio, 2007 - 2009.

Certification: American Board of Surgery, 2007; American Board of Surgery, Certification in Pediatric Surgery, 2008.

Publications

View PubMed Publications

Ryckman FC, Bucuvalas JC, Nathan J, Alonso M, Tiao G, Balistreri WF. Outcomes following liver transplantation. Semin Pediatr Surg. 2008 May;17(2):123-30.

Follmar KE, Condron SA, Turner II, Nathan JD, Ludwig KA. Treatment of metronidazole-refractory Clostridium difficile enteritis with vancomycin. Surg Infect. 2008 9:195-200.

Patel MB, Nathan JD, Frush DP, Rice HE. Nonoperative management of asymptomatic traumatic pulmonary hernia in a young child. J Trauma. 2007 62:234-235.

Nathan JD, Romac J, Peng RY, Peyton M, MacDonald RJ, Liddle RA. Transgenic expression of pancreatic secretory trypsin inhibitor-I ameliorates secretagogue-induced pancreatitis in mice. Gastroenterology. 2005 128:717-727.

Eisenberg ML, Maker AV, Slezak LA, Nathan JD, Sritharan KC, Jena BP, Geibel JP, Andersen DK. Insulin receptor (IR) and glucose transporter 2 (GLUT2) proteins form a complex on the rat hepatocyte membrane. Cell Physiol Biochem. 2005 15:51-58.

Book Chapters

Nathan JD, Campbell KM, Tiao GM, Alonso MH, Ryckman FC. Portal hypertension. In: Mattei P, ed. Fundamentals of Pediatric Surgery (2nd edition).

Ryckman FC, Alonso MH, Nathan JD, Tiao G. Solid organ and intestinal transplantation. In: Holcomb WH, Murphy JP, eds. Pediatric Surgery (5th edition).

Nathan JD, Ryckman FC. Biliary atresia. In: Chung DH, ed. Atlas of Pediatric Surgical Techniques: A Volume in the Surgical Techniques Atlas Series (1st edition).

Frederick C. Ryckman, MD
Vice President, System Capacity & Perioperative Operations

513-636-4371

frederick.ryckman@cchmc.org

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Frederick C. Ryckman, MD

Vice President, System Capacity & Perioperative Operations

Director, Pediatric Surgery Training Program

Professor, Division of Pediatric Surgery

Phone: 513-636-4371

Fax: 513-636-7657

Email: frederick.ryckman@cchmc.org

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Specialties

Transplantation; liver; kidney transplantation; small intestine; biliary disease; Extracorporeal membrane oxygenation (ECMO); minimally invasive surgery; chest wall abnormalities

Biography

Frederick C. Ryckman, MD, is clinical director of the Pediatric General and Thoracic Surgery Division.

Dr. Ryckman is also vice president of System Capacity & Perioperative Operations.

Dr. Ryckman is also a pediatric surgeon at the Fetal Care Center of Cincinnati.

Education and Training

BS: Lyman Briggs College of Science and Mathematics, Michigan State University, East Lansing, MI, 1969 to 1973.

MD: University of Michigan Medical School, Ann Arbor, MI, 1977.

Residency: University of Florida Medical Center, Gainesville, FL, 1977 to 1982.

Fellowship: Pediatric Surgery, Children's Hospital Medical Center, Cincinnati, OH, 1982 to 1984.

Certification: National Board of Medical Examiners, 1977; American Board of Surgery, 1983; recertification, 1993; Certificate of Special Competence in Pediatric Surgery, 1986; recertification, 1993.

Publications

View PubMed Publications

Wagner LM, Gelfand MJ, Laor T, Ryckman FC, Al-Ghawi H, Bove KE. A Welcome Surprise: Nodular Fasciitis Presenting as Soft Tissue Sarcoma. J Pediatr Hematol Oncol. 2010 Oct 21.

Taylor JA, Ryckman FC. Management of small bowel volvulus around feeding Roux-en-Y limbs. Pediatr Surg Int. 2010 Apr;26(4):439-42.

Ryckman FC, Yelton PA, Anneken AM, Kiessling PE, Schoettker PJ, Kotagal UR. Redesigning intensive care unit flow using variability management to improve access and safety. Jt Comm J Qual Patient Saf. 2009 Nov;35(11):535-43.

Rattan AS, Laor T, Ryckman FC, Brody AS. Pectus excavatum imaging: enough but not too much. Pediatr Radiol. 2010 Feb;40(2):168-72.

Propst EJ, Lin EP, Istaphanous GK, Boesch RP, Ryckman FC, Cotton RT, Rutter MJ. Management of traumatic tracheobronchial separation in a teenager using a fabricated extra-long endotracheal tube. Int J Pediatr Otorhinolaryngol. 2009 Aug;73(8):1163-7.

Ryckman FC, Schoettker PJ, Hays KR, Connelly BL, Blacklidge RL, Bedinghaus CA, Sorter ML, Friend LC, Kotagal UR. Reducing surgical site infections at a pediatric academic medical center. Jt Comm J Qual Patient Saf. 2009 Apr;35(4):192-8.

Dickie B, Dasgupta R, Nair R, Alonso MH, Ryckman FC, Tiao GM, Adams DM, Azizkhan RG. Spectrum of hepatic hemangiomas: management and outcome. J Pediatr Surg. 2009 Jan;44(1):125-33.

Ryckman FC, Bucuvalas JC, Nathan J, Alonso M, Tiao G, Balistreri WF. Outcomes following liver transplantation. Semin Pediatr Surg. 2008 May;17(2):123-30.

Sparling KW, Ryckman FC, Schoettker PJ, Byczkowski TL, Helpling A, Mandel K, Panchanathan A, Kotagal UR. Financial impact of failing to prevent surgical site infections. Qual Manag Health Care. 2007 Jul-Sep;16(3):219-25.

Andrew Patrick South, MD, MPH

513-803-0998

andrew.south@cchmc.org

High Res

Andrew Patrick South, MD, MPH

Assistant Professor, UC Department of Pediatrics

Phone: 513-803-0998

Fax: 513-803-0968

Email: andrew.south@cchmc.org

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Specialties

Epidemiology and prevention of late-preterm birth; long term outcome of infants born with gastroschisis

Education and Training

MD: Case Western Reserve University, Cleveland, OH, 2000.

Residency: Pediatrics, University of North Carolina Children’s Hospital, Chapel Hill, NC.

Fellowship: Neonatology, University of North Carolina Children’s Hospital, Chapel Hill, NC.

Certification: Pediatrics, 2004; Neonatology, 2008.

Publications

View PubMed Publications

Slaughter JL, Pakrashi T, Jones DE, South AP, Shah TA. Echocardiographic detection of pulmonary hypertension in extremely low birth weight infants with bronchopulmonary dysplasia requiring prolonged positive pressure ventilation. J Perinatol. 2011 Feb 10.

South AP, Wessel JJ, Sberna A, Patel M, Morrow AL. Hospital readmission among infants with gastroschisis. J Perinatol. 2011 Feb 10.

South AP, Jones DE, Hall ES, Huo S, Meinzen-Derr J, Liu L, Greenberg JM. Spatial Analysis of Preterm Birth Demonstrates Opportunities for Targeted Intervention. Matern Child Health J. 2011 Feb 3.

Winik BC, Asial RA, McGrath JA, South AP, Boente MC. Acantholytic ectodermal dysplasia: clinicopathological study of a new desmosomal disorder. Br J Dermatol. 2009 Apr;160(4):868-74.

South AP, Marshall DD, Bose CL, Laughon MM. Growth and neurodevelopment at 16 to 24 months of age for infants born with gastroschisis. J Perinatol. 2008 Oct;28(10):702-6.

South MMT, Strauss RA, South AP, Boggess JF, Thorp JM. The use of non-nutritive sucking to decrease the physiologic pain response during neonatal circumcision: A randomized controlled trial. Am J of Obstet and Gynec 2005;193:537-43.

Grischkan J, Storfer-Isser A, Rosen CL, Larkin EK, Kirchner HL, South A, Wilson-Costello DC, Martin RJ, Redline S. Variation in childhood asthma among former preterm infants. J Pediatr 2004;144:321-6.

Greg M. Tiao, MD
Surgical Director, Liver Transplantation

513-636-4371

greg.tiao@cchmc.org

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Greg M. Tiao, MD

Surgical Director, Liver Transplantation

Director, Small Bowel Program

Associate Director, Pediatric Surgery Training Program

Pediatric Surgeon

Associate Professor, Division of Pediatric Surgery

Phone: 513-636-4371

Fax: 513-636-7657

Email: greg.tiao@cchmc.org

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Specialties

Liver, kidney and small bowel transplantation; hepatobiliary disease; Neonatal surgery; biliary atresia; minimally invasive surgery

Biography

As a pediatric surgeon and a transplant surgeon, I am involved in the care of children afflicted with biliary atresia from the time of presentation and diagnosis to the initial Kasai portoenterostomy to the liver transplant when necessary. I see the many challenges a child and their family experience when diagnosed with this life threatening disease process. From that perspective, defining the basis of this disease process such that therapeutic strategies can be developed eliminating these complex interventions is my career goal. Our short term goal is to develop an independent research laboratory investigating the pathogenesis of virus induced biliary atresia specifically seeking to determine the mechanistic basis of this disease so that new treatment strategies can be developed to salvage the native liver.

Our overarching hypothesis is that biliary atresia results from the infection of cholangiocytes by a virus triggering immune-mediated biliary obstruction.Our focus is to determine the mechanisms used by RRV to infect cholangiocytes, how RRV undergoes replication within the cholangiocyte, how infected cholangiocytes modify the microenvironment activating the immune system resulting in biliary obstruction. Determination of the mechanistic basis of these inter-related events is essential to understanding the pathogenesis of virus induced BA. By focusing on the basis for the viral insult in the initiation of biliary atresia, I have defined an area of independence from Dr Jorge Bezerra, my primary research mentor.

Education and Training

BS: Northwestern University, Evanston, IL, 1986.

MD: University of Illinois, Chicago, IL, 1990.

Residency: Loyola University, Maywood, IL, 1991-1992; Senior Resident, Department of Surgery, University of Cincinnati, Cincinnati, OH, 1995-1997;Chief Resident, Department of Surgery, University of Cincinnati, Cincinnati, OH, 1997-1998.

Fellowships: Research Fellow, University of Cincinnati, Cincinnati, OH, 1992-1995; Transplant Surgery Fellow, University of Cincinnati, Cincinnati, OH, 2000-2002;Pediatric Surgery Fellow, Los Angeles Children's Hospital, Los Angeles, CA, 1998-2000.

Publications

Fernandez KS, Baum R, Fung B, Yeager N, Leonis MA, Wagner LM, Tiao G Ross ME. Chemoresistant hepatoblastoma in a patient with mosaic trisomy 18 treated with orthotopic liver transplantation. Peditr Blood Cancer 2011;56(3):498-500.

Bondoc A, Jafri M, Donnelly B, Mohanty S, McNeal M, Ward R, Tiao G. Prevention of the murine model of biliary atresia after live rotavirus vaccination of dams. J of Pediatric Surgery. 2009;44(8):1479-90. PMCID: PMC2748872

Jafri M, Donnelly B, Bondoc A, Allen S, Tiao G. Cholangiocyte secretion of chemokines in experimental biliary atresia. J of Pediatric Surgery. 2009;44(3):500-507. PMCID: PMC2730110

Jafri M, Donnelly B, Allen S, Bondoc A, McNeal M, Rennert PD, Weinreb PH, Ward R, Tiao G. Cholangiocyte expression of alpha2beta1-integrin confers susceptibility to rotavirus-induced experimental biliary atresia. Am J Physiol Gastrointest Liver Physiol. 2008;295(1):G16-G26. PMCID: PMC2494723

Allen SR, Jafri M, Donnelly B, McNeal M, Witte D, Bezerra J, Ward R, Tiao GM. Effect of rotavirus strain on the murine model of biliary atresia. J Virol. 2007;81(4):1671-9.

Jafri M, Donnelly B, McNeal M, Ward R, Tiao G. MAPK signaling contributes to rotaviral-induced cholangiocyte injury and viral replication. Surgery. 2007;142(2):192-201.

Tiao GM, Alonso MH, Ryckman FC. Pediatric liver transplantation. Semin Pediatr Surg. 2006;15(3):218-227.

Tiao G, Alonso M, Bezerra J, Yazigi N, Heubi J, Balistreri W, Bucuvalas J, Ryckman F. Liver transplantation in children under one year of age-the cincinnati experience. J Pediatr Surg. 2005;40(1):268-273.

Zhang DY, Sabla G, Shivakumar P, Tiao G, Sokol RJ, Mack C, Schneider GL, Aronow B, Bezerra JA. Coordinate expression of regulatory genes differentiates embryonic and perinatal forms of biliary atresia. Hepatology. 2004;39(4):954-962.

Shivakumar P, Cambell KM, Sabla GE, Mietke A, Tiao G, McNeal NM, Ward RL, Bezerra JA. Obstruction of extrahepatic bile ducts by lymphocytes is regulated by IFN-gamma in experimental biliary atresia. J Clin Invest. 2004;114(3):322-329.

Grants

The Molecular Determinants of Virus Induced Biliary Induced Biliary Asteria. Principal Investigator. Apr 2011-Marh 2016.

Intracellular Signaling Pathways and Virus Induced Biliary Asteria. Principal Investigator. May 2010-Apr 2012.

Nada Yazigi, MD
Pediatric Gastroenterologist

513-636-4415

nada.yzigi@cchmc.org

High Res

Nada Yazigi, MD

Pediatric Gastroenterologist

Assistant Professor, UC Department of Pediatrics

Phone: 513-636-4415

Fax: 513-636-7805

Email: nada.yzigi@cchmc.org

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Specialties

Chronic liver disorders; liver transplantation; acute liver failure; inflammatory bowel disorders

Biography

Nada Yazigi, MD, completed her pediatric training at the Medical College of Virginia, Richmond, Virginia. She subsequently finished a Pediatric Gastroenterology fellowship with focus on liver disease and liver transplantation at Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio. She then entered the public health service where she served at Mount Sinai Medical Center in Chicago, Illinois.

Dr Yazigi's long term interest has been in liver disorders and transplantation, currently the focus of her clinical practice at Cincinnati Children's. Her research interests are inflammatory mechanisms and novel treatment modalities for children with acute liver failure.

Dr Yazigi directs the GI elective rotations for residents and students. She is also actively involved in the hospital wide Process Improvement Project, as team leader on the inpatient Clinical System Improvement.

Education and Training

MD: Saint Joseph University Medical School, Beirut, Lebanon, 1987.

Residency: Pediatrics, Medical College of Virginia, Richmond, VA, 1993.

Fellowship: Pediatric Gastroenterology, Children's Hospital Medical Center, Cincinnati, OH, 1993-1997.

Certification: Pediatrics, 1993; Pediatric Gastroenterology, 1997.

Publications

View PubMed Publications

Pasternak B, Grom A, Yazigi N, Cohen MB. Suppurative peripheral arthritis in inflammatory bowel disease. J Pediatr Gastroenterol Nutr. 2007 Jul;45(1):117-20.

Squires RH Jr, Shneider BL, Bucuvalas J, Alonso E, Sokol RJ, Narkewicz MR, Dhawan A, Rosenthal P, Rodriguez-Baez N, Murray KF, Horslen S, Martin MG, Lopez MJ, Soriano H, McGuire BM, Jonas MM, Yazigi N, Shepherd RW, Schwarz K, Lobritto S, Thomas DW, Lavine JE, Karpen S, Ng V, Kelly D, Simonds N, Hynan LS. Acute liver failure in children: the first 348 patients in the pediatric acute liver failure study group. J Pediatr. 2006 May;148(5):652-658.

Campbell KM, Yazigi N, Ryckman FC, Alonso M, Tiao G, Balistreri WF, Atherton H, Bucuvalas JC. High prevalence of renal dysfunction in long-term survivors after pediatric liver transplantation. J Pediatr. 2006 Apr;148(4):475-80.

Bucuvalas J, Yazigi N, Squires RH Jr. Acute liver failure in children. Clin Liver Dis. 2006 Feb;10(1):149-68, vii. Review.

Tiao GM, Alonso M, Bezerra J, Yazigi N, Heubi J, Balistreri W, Bucuvalas J, Ryckman F. Liver transplantation in children younger than 1 year--the Cincinnati experience. J Pediatr Surg. 2005 Jan;40(1):268-73.

Xanthakos SA, Yazigi NA, Ryckman FC, Arkovitz MS. Spontaneous perforation of the bile duct in infancy: a rare but important cause of irritability and abdominal distension. J Pediatr Gastroenterol Nutr. 2003 Feb;36(2):287-91.