Diagnostic Center for Heritable Immunodeficiencies

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Diagnostic Center for Heritable Immunodeficiencies.

The Diagnostic Center for Heritable Immunodeficiencies (DCHI) at Cincinnati Children’s is the largest and most specialized center in North America for the diagnosis and management of rare primary immunodeficiencies and other disorders of the immune system.

The DCHI has been recognized as a center of excellence by the Federation of Clinical Immunology Societies and the Jeffrey Modell Foundation.

Our Specialty Services

Go to the Molecular Genetics Laboratory web page. Molecular Genetics Laboratory
High-quality molecular genetic testing and sophisticated interpretation of results by clinical and genetics experts

Go to the Diagnostic Immunology Lab web page. Diagnostic Immunology Laboratory
Correlated functional assays for a wide range of immune diseases

Go to the Immune Deficiency and Histiocytosis web page. Immunodeficiencies and Histiocytosis Program (Clinical)
Experienced medical management including one of the country’s largest stem cell transplantation programs

Why Choose Us

Our Expertise

DCHI gives you unparalleled clinical expertise and provides guidance in test selection, clinical interpretation, recommendations for genetic counseling, clinical management and coordination of studies for at-risk family members.

Alexandra Filipovich, MD

Director, Immune Deficiency and Histiocytosis Program; medical director, Diagnostic Immunology Lab. Clinical interests: primary immunodeficiencies, BMT for primary immunodeficiencies, hemophagocytic lymphocytosis, post-BMT immune reconstruction.

Kejian Zhang, MD, MBA

Director, Molecular Genetics Laboratory. Clinical interests: molecular genetics diagnosis of inherited immunodeficiency disorders and other genetic conditions.

Jacob Bleesing, MD, PhD

Clinical interests: immunobiology, translational research, immunologic methods development. Research interests: clinical investigation of primary immunodeficiency disorders, immunoreconstitution following blood and marrow transplantation, diagnostic immunology.

Our Expertise

Alexandra Filipovich, MD

Kejian Zhang, MD, MBA

Jacob Bleesing, MD, PhD