Diagnostic Center for Heritable Immunodeficiencies

  • Meet the Team

    The Diagnostic Center for Heritable Immunodeficiencies team at Cincinnati Children's Hospital Medical Center is comprised of specialists in human and molecular genetics, immunodeficiency and histiocytosis. 

    Recognized Excellence in Clinical Testing and Patient Care

    • A FOCIS Center of Excellence
    • A Jeffrey Modell Center of Excellence
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    Experts

    Jacob (Jack) J.H. Bleesing, MD, PhD

    Associate Professor, UC Department of Pediatrics

    Phone: 513-636-4266

    Fax: 513-636-3549

    Email: jack.bleesing@cchmc.org

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    Specialties

    Clinical Interests

    Immunobiology; translational research; immunologic methods development

    Research Interests

    Clinical investigation of primary immunodeficiency disorders (with emphasis on disorders of immuno dysregulation and B-cell disorders); immuno-reconstitution following blood and marrow transplantation; diagnostic immunology (with emphasis on flow cytometry) 

    Education and Training

    MD: University of Leiden, Leiden, The Netherlands, 1989.

    PhD: University of Leiden, Leiden, The Netherlands, 2002.

    Residency: Pediatrics, University of Florida, Gainesville, Florida, 1993.

    Fellowship: Allergy/Immunology, Duke University Medical Center, Durham, North Carolina, 1995.

    Fellowship: Clinical Laboratory Immunology, National Institutes of Health, Bethesda, Maryland, 2001.

    Publications

    View PubMed Publications
    A photo of Stella Davies.

    Stella M. Davies, MBBS, PhD, MRCP
    Director, Bone Marrow Transplantation and Immune Deficiency

    513-636-1371

    stella.davies@cchmc.org

    Stella M. Davies, MBBS, PhD, MRCP

    Director, Bone Marrow Transplantation and Immune Deficiency

    Jacob G. Schmidlapp Endowed Chair

    Professor, UC Department of Pediatrics

    Phone: 513-636-1371

    Fax: 513-803-1969

    Email: stella.davies@cchmc.org

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    Specialties

    Education and Training

    MBBS: University of Newcastle-Upon-Tyne, England, 1981.

    Clinical and Fellowship Training: The Royal Victoria Infirmary, Newcastle General Hospital and Great Ormond St. Hospital, 1981 to 1985.

    PhD: University of Newcastle-Upon-Tyne, England, 1989.

    Pediatric Fellowship: University of Minnesota, Minneapolis, MN, 1989 to 1993.

    Publications

    View PubMed Publications

    A photo of Lisa Filipovich.

    Alexandra (Lisa) H. Filipovich, MD
    Ralph J. Stolle Chair, Clinical Immunology

    513-803-3218

    lisa.filipovich@cchmc.org

    Alexandra (Lisa) H. Filipovich, MD

    Ralph J. Stolle Chair, Clinical Immunology

    Director, Immune Deficiency and Histiocytosis Program

    Medical Director, Diagnostic Immunology Laboratory

    Professor, UC Department of Pediatrics

    Phone: 513-803-3218

    Fax: 513-803-1969

    Email: lisa.filipovich@cchmc.org

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    Specialties

    Clinical Interests

    Primary immunodeficiencies; BMT for primary immunodeficiencies; hemophagocytic lymphocytosis; post-BMT immune reconstruction

    Research Interests

    Biology and genetics of hemophagocytic lymphohistiocytosis; investigation of hematopoietic cell transplantation for genetic immunodeficiencies; immunoreconstitution following pediatric stem cell transplantation

    Biography

    Lisa Filipovich, MD, began her career at the University of Minnesota where she received her medical degree in 1974 and completed fellowships in both immunopathology and pediatric immunology. She became a professor of pediatrics and served for 10 years as the head of the Division of Immunology at the University of Minnesota Medical School. Dr. Filipovich came to Cincinnati Children’s in 1996. She is currently the Ralph J. Stolle Chair in Clinical Immunology and the director of the Immune Deficiency and Histiocytosis program. She also serves as the medical director of the Diagnostic Immunology Laboratory at Cincinnati Children’s.

    Dr. Filipovich has a special interest in histiocytic disorders, especially hemophagocytic lymphohistiocytosis (HLH). Other interests include bone marrow transplant for primary immune deficiencies and post-BMT immune reconstitution. She serves as president of the Histiocyte Society, an international group of more than 200 physicians and scientists who are committed to improving the lives of patients with histiocytosis through research.

    Education and Training

    MD: University of Minnesota, Minneapolis, MN, 1974.

    Residency: University of Minnesota Hospitals, Minneapolis, MN 1975-1978.

    Fellowship: Immunopathology, Departments of Pediatrics, Laboratory Medicine and Pathology, University of Minnesota 1978-1979.

    Fellowship: Pediatric Immunology, Department of Pediatrics, University of Minnesota 1979-1980.

    Certification: Pediatrics, 1980.

    Publications

    View PubMed Publications

    Grants

    Gene Therapy for SCID-X1 Using Self-Inactivating Gamma. Principal Investigator. National Institutes of Health. Sep 2010-Aug 2015. #U01 AI 087628.

    Rare Diseases Clinical Consortia for the Rare Diseases. Principal Investigator. National Institutes of Health. Sep 2009-Aug 2014. #U54 AI 082973.

    Hypoxia and potassium channel activity in T Lymphocytes. Principal Investigator. National Institutes of Health. Jun 2009-Jun 2014. #R01 CA 095286.

    Parinda A. Mehta, MD

    Associate Professor, UC Department of Pediatrics

    Phone: 513-636-4913

    Fax: 513-803-1969

    Email: parinda.mehta@cchmc.org

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    Education and Training

    Fellowship: Cincinnati Children's Hospital Medical Center, 2005.

    Residency: Upstate Medical University (UMU) - State University of New York (SUNY), Syracuse, NY, 2002.

    MD: G.S. Medical College and K.E.M Hospital, Mumbai, India, 1993.

    BA: Graduated from Parle College, Mumbai, India, 1988.

    Certification: Board Certification: Pediatrics, 2002; Board Certification: Pediatric Hematology Oncology; License: State of Ohio.

    Publications

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    Kasiani C. Myers, MD

    Assistant Professor, UC Department of Pediatrics

    Phone: 513-636-7287

    Email: kasiani.myers@cchmc.org

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    Biography

    Dr. Myers received her medical degree from Case Western Reserve University and pursued training in pediatrics and hematology/oncology at Cincinnati Children’s Hospital Medical Center. After completion of her postdoctoral training, she joined the faculty at Cincinnati Children’s in the Division of Bone Marrow Transplantation and Immune Deficiency. She is a recipient of the Procter Scholar Award to support her translational research in the field of Fanconi anemia.

    Education and Training

    BS: University of Michigan, 2000.

    MD: Case Western Reserve University, 2004.

    Post-Doctoral: Cincinnati Children’s Hospital Medical Center, 2010.

    Certification: Pediatrics, 2007.

    Publications

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    A photo of Kejian Zhang.

    Kejian Zhang, MD, MBA
    Director, Molecular Genetics Laboratory

    513-636-0121

    kejian.zhang@cchmc.org

    Kejian Zhang, MD, MBA

    Director, Molecular Genetics Laboratory

    Associate Professor, UC Department of Pediatrics

    Phone: 513-636-0121

    Fax: 513-636-2261

    Email: kejian.zhang@cchmc.org

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    Specialties

    Clinical Interests

    Molecular genetics diagnosis of inherited immunodeficiency disorders and other genetic conditions

    Research Interests

    Molecular defects and molecular diagnosis of primary immunodeficiency diseases; Genetic aspects of predictive personalized medicine (pharmacogenetics)

    Education and Training

    MD: Tianjin Medical University, Tianjin, China, 1993

    MBA: University of Cincinnati, College of Business Administration, 2001

    Residency: Gong'an Hospital, Tianjin, China, 1993-1995

    Fellowship: Clinical Molecular Genetics Fellow, Division of Human Genetics, Cincinnati Children's Hospital, 2002-2004

    Publications

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    Grants

    Macrophage Activation Syndrome Biomarkers in Systemic Juvenile Idiopathic Arthritis. Co-investigator. National Institute of Arthritis, Musculoskeletal and Skin Diseases. Aug 2007 - Dec 2012.

    MUNC13-4 gene Polymorphisms in Macrophage Activation syndrome and Systemic Juvenile Idiopathic Arthritis. Co-Investigator. National Institute of Health. Sept 2011 - Aug 2016.