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The Ear and Hearing Center is home to specialists with a wide variety of backgrounds and areas of focus. As a team, this diversity makes us better prepared to care for your child’s unique needs. Learn more about our faculty and staff.
Daniel I. Choo, MD Director, Division of Pediatric Otolaryngology - Head and Neck Surgery
Director, Division of Pediatric Otolaryngology - Head and Neck Surgery
Professor, UC Department of Pediatrics
UC Department of Otolaryngology – Head and Neck Surgery
Diagnosis and management of children with hearing loss; pediatric cochlear implantation; surgery for congenital ear abnormalities; hearing restoration surgery; disorders of the endolymphatic system of the inner ear (e.g., Meniere's Disease).
Development of the inner ear; Meniere's disease
Daniel Choo, MD, obtained his medical degree from the State University of New York Health Science Center at Syracuse, NY, and completed his otolaryngology residency training in Syracuse.
Dr. Choo completed fellowships in otology / neurotology at the Ear Research Foundation in Sarasota, Florida and the Neurotology Branch of the National Institute on Deafness and Other Communication Disorders (NIDCD), National Institutes of Health, Bethesda, MD.
MD: State University of New York Health Science Center at Syracuse, Syracuse, NY, 1989.
Fellowship: Neuro-otology, Ear Research Foundation, Sarasota, Fla., 1995; Molecular and Developmental Biology of the Inner Ear, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, 1999.
Residency: State University of New York Health Science Center at Syracuse, Syracuse, NY, 1994.
Certification: American Board of Otolaryngology, 1995.
John H. Greinwald Jr., MD, FAAP
Sun GH, Harmych BM, Dickson JM, Gonzalez Del Rey JA, Myer CM 3rd, Greinwald JH Jr. Characteristics of children diagnosed as having coagulopathies following posttonsillectomy bleeding. Arch Otolaryngol Head Neck Surg. 2011 Jan;137(1):65-8.
Johnson RF, Cohen AP, Guo Y, Schibler K, Greinwald JH. Genetic mutations and aminoglycoside-induced ototoxicity in neonates. Otolaryngol Head Neck Surg. 2010 May;142(5):704-7.
Hopkins BS, Johnson KE, Ksiazek JM, Sun G, Greinwald JH, Rutter M. H1N1 influenza A presenting as bacterial tracheitis. Otolaryngol Head Neck Surg. 2010 Apr;142(4):612-4.
Kothiyal P, Cox S, Ebert J, Husami A, Kenna MA, Greinwald JH, Aronow BJ, Rehm HL. High-throughput detection of mutations responsible for childhood hearing loss using resequencing microarrays. BMC Biotechnol. 2010 Feb 10;10:10.
Propst EJ, Greinwald JH, Schmithorst V. Neuroanatomic differences in children with unilateral sensorineural hearing loss detected using functional magnetic resonance imaging. Arch Otolaryngol Head Neck Surg. 2010 Jan;136(1):22-6.
Kothiyal P, Cox S, Ebert J, Aronow BJ, Greinwald JH, Rehm HL. An overview of custom array sequencing. Curr Protoc Hum Genet. 2009 Apr;Chapter 7:Unit 7.17.
Lee KH, Larson DA, Shott G, Rasmussen B, Cohen AP, Benton C, Halsted M, Choo D, Meinzen-Derr J, Greinwald JH Jr. Audiologic and temporal bone imaging findings in patients with sensorineural hearing loss and GJB2 mutations. Laryngoscope. 2009 Mar;119(3):554-8.
Greinwald J Jr, Cohen AP, Hemanackah S, Azizkhan RG. Massive lymphatic malformations of the head, neck, and chest. J Otolaryngol Head Neck Surg. 2008 Apr;37(2):169-73.
Schraff SA, Schleiss MR, Brown DK, Meinzen-Derr J, Choi KY, Greinwald JH, Choo DI. Macrophage inflammatory proteins in cytomegalovirus-related inner ear injury. Otolaryngol Head Neck Surg. 2007 Oct;137(4):612-8.
Vijayasekaran S, Halsted MJ, Boston M, Meinzen-Derr J, Bardo DM, Greinwald J, Benton C. When is the vestibular aqueduct enlarged? A statistical analysis of the normative distribution of vestibular aqueduct size. AJNR Am J Neuroradiol. 2007 Jun-Jul;28(6):1133-8.
Min-Xin Guan, PhD
Adjunct Professor, UC Department of Pediatrics
Mitochondrial biogenesis, cellular and molecular biology of mitochondrial disorders, especially in hearing loss and neuromuscular disorders.
Guan MX. Mitochondrial 12S rRNA mutations associated with aminoglycoside ototoxicity. Mitochondrion. 2011 Mar;11(2):237-45.
Li R, Guan MX. Human mitochondrial leucyl-tRNA synthetase corrects mitochondrial dysfunctions due to the tRNALeu(UUR) A3243G mutation, associated with mitochondrial encephalomyopathy, lactic acidosis, and stroke-like symptoms and diabetes. Mol Cell Biol. 2010 May;30(9):2147-54.
Wang X, Yan Q, Guan MX. Combination of the loss of cmnm5U34 with the lack of s2U34 modifications of tRNALys, tRNAGlu, and tRNAGln altered mitochondrial biogenesis and respiration. J Mol Biol. 2010 Feb 5;395(5):1038-48.
Qian Y, Guan MX. Interaction of aminoglycosides with human mitochondrial 12S rRNA carrying the deafness-associated mutation. Antimicrob Agents Chemother. 2009 Nov;53(11):4612-8.
Li R, Liu Y, Li Z, Yang L, Wang S, Guan MX. Failures in mitochondrial tRNAMet and tRNAGln metabolism caused by the novel 4401A>G mutation are involved in essential hypertension in a Han Chinese Family. Hypertension. 2009 Aug;54(2):329-37.
Wang X, Yan Q, Guan MX. Mutation in MTO1 involved in tRNA modification impairs mitochondrial RNA metabolism in the yeast Saccharomyces cerevisiae. Mitochondrion. 2009 Jun;9(3):180-5.
Wang X, Lu J, Zhu Y, Yang A, Yang L, Li R, Chen B, Qian Y, Tang X, Wang J, Zhang X, Guan MX. Mitochondrial tRNAThr G15927A mutation may modulate the phenotypic manifestation of ototoxic 12S rRNA A1555G mutation in four Chinese families. Pharmacogenet Genomics. 2008 Dec;18(12):1059-70.
Wang X, Yan Q, Guan MX. Deletion of the MTO2 gene related to tRNA modification causes a failure in mitochondrial RNA metabolism in the yeast Saccharomyces cerevisiae. FEBS Lett. 2007 Sep 4;581(22):4228-34.
Guan MX, Yan Q, Li X, Bykhovskaya Y, Gallo-Teran J, Hajek P, Umeda N, Zhao H, Garrido G, Mengesha E, Suzuki T, del Castillo I, Peters JL, Li R, Qian Y, Wang X, Ballana E, Shohat M, Lu J, Estivill X, Watanabe K, Fischel-Ghodsian N. Mutation in TRMU related to transfer RNA modification modulates the phenotypic expression of the deafness-associated mitochondrial 12S ribosomal RNA mutations. Am J Hum Genet. 2006 Aug;79(2):291-302.
Li R, Qu J, Zhou X, Tong Y, Hu Y, Qian Y, Lu F, Mo JQ, West CE, Guan MX. The mitochondrial tRNA(Thr) A15951G mutation may influence the phenotypic expression of the LHON-associated ND4 G11778A mutation in a Chinese family. Gene. 2006 Jul 5;376(1):79-86.
Scott K. Holland, PhD Director, Pediatric Neuroimaging Research Consortium
Director, Pediatric Neuroimaging Research Consortium
UC Department of Radiology
Advanced neuroimaging applications of MRI in pediatrics; functional MRI of language, hearing and neuroplasticity following brain injury; brain development.
Scott K. Holland, PhD, is the McLaurin Scholar in pediatric neurosurgery and professor of radiology, pediatrics, biomedical engineering, neuroscience and physics at University of Cincinnati, and director of the Pediatric Brain Imaging Research Center at Children’s Hospital Research Foundation. A physicist by training, he received his BS degree (1980) in physics from Muhlenberg College, Allentown, PA., MS (1982) and PhD (1985) degrees in applied physics from Yale University.
Tlustos SJ, Chiu CY, Walz NC, Holland SK, Bernard L, Wade SL. Neural correlates of interference control in adolescents with traumatic brain injury: functional magnetic resonance imaging study of the counting Stroop task. J Int Neuropsychol Soc. 2011 Jan;17(1):181-9.
Schmithorst VJ, Holland SK, Plante E. Diffusion Tensor Imaging Reveals White Matter Microstructure Correlations With Auditory Processing Ability. Ear Hear. 2010 Nov 8.
Yuan W, Deren KE, McAllister JP 2nd, Holland SK, Lindquist DM, Cancelliere A, Mason M, Shereen A, Hertzler DA, Altaye M, Mangano FT. Diffusion tensor imaging correlates with cytopathology in a rat model of neonatal hydrocephalus. Cerebrospinal Fluid Res. 2010 Nov 5;7:19.
Smith KM, Mecoli MD, Altaye M, Komlos M, Maitra R, Eaton KP, Egelhoff JC, Holland SK. Morphometric Differences in the Heschl's Gyrus of Hearing Impaired and Normal Hearing Infants. Cereb Cortex. 2010 Sep 13.
Kaimal V, Chu Z, Mahller YY, Papahadjopoulos-Sternberg B, Cripe TP, Holland SK, Qi X. Saposin C Coupled Lipid Nanovesicles Enable Cancer-Selective Optical and Magnetic Resonance Imaging. Mol Imaging Biol. 2010 Sep 14.
Szaflarski JP, Eaton K, Ball AL, Banks C, Vannest J, Allendorfer JB, Page S, Holland SK. Poststroke Aphasia Recovery Assessed With Functional Magnetic Resonance Imaging and a Picture Identification Task. J Stroke Cerebrovasc Dis. 2010 Aug 17.
Szaflarski JP, DiFrancesco M, Hirschauer T, Banks C, Privitera MD, Gotman J, Holland SK. Cortical and subcortical contributions to absence seizure onset examined with EEG/fMRI. Epilepsy Behav. 2010 Aug;18(4):404-13.
Air EL, Yuan W, Holland SK, Jones BV, Bierbrauer K, Altaye M, Mangano FT. Longitudinal comparison of pre- and postoperative diffusion tensor imaging parameters in young children with hydrocephalus. J Neurosurg Pediatr. 2010 Apr;5(4):385-91.
Karunanayaka P, Schmithorst VJ, Vannest J, Szaflarski JP, Plante E, Holland SK. A group independent component analysis of covert verb generation in children: a functional magnetic resonance imaging study. NeuroImage. 2010 May 15;51(1):472-87.
Leach JL, Holland SK. Functional MRI in children: clinical and research applications. Pediatr Radiol. 2010 Jan;40(1):31-49.
Gayle Riemer, MA, CCC-A, F-AAA Audiologist III, Division of Audiology
Susan E. Wiley, MD Co-Director, Division of Developmental and Behavioral Medicine
Co-Director, Division of Developmental and Behavioral Medicine
Pediatrician, Division of Developmental and Behavioral Pediatrics
UC Department of Otolaryngology, Head & Neck Surgery
Pediatric hearing loss; dual sensory impairment; deaf/hard of hearing plus; children with neurodevelopmental disabilities
Dual sensory impairment; deaf/hard of hearing plus; more than hearing loss
Dr. Wiley has served on state and national organizations to improve the early hearing detection and intervention activities across the United States. She served as the faculty chair on Improving Hearing Screening and Information Systems Initiative for the National Initiative for Children’s Healthcare Quality (2011-2013) and is a taskforce member with the American Academy of Pediatrics to identify strategies to improve linkage of Universal Newborn Hearing Screening (UNHS) to the medical home.
MD: University of Cincinnati, OH, 1994.
Residency: Pediatrics, Children's Hospital Medical Center of Cincinnati, OH.
Fellowship: Developmental Pediatrics, Cincinnati Center for Developmental Disorders, Cincinnati, OH.
Certification: Pediatrics, 1997.
Certification: Developmental-Behavioral Pediatrics, 2002.
Meinzen-Derr J, Wiley S, Grether S, Phillips J, Choo D, Hibner J, Barnard H. Functional communication of children who are deaf or hard-of-hearing. J Dev Behav Pediatr. 2014 Apr;35(3):197-206.
Wiley S, Gustafson S, Rozniak J. Needs of parents of children who are deaf/hard of hearing with autism spectrum disorder. J Deaf Stud Deaf Educ. 2014 Jan;19(1):40-9.
Meinzen-Derr J, Wiley S, Bishop S, Manning-Courtney P, Choo D, Gustafson S, Murray D. Autism spectrum disorders in children who are deaf or hard of hearing. Int J Pediatr Otorhinolaryngol. 2014 Jan;78(1):112-8.
Wiley S, Meinzen-Derr J. Use of the ages and stages questionnaire in young children who are deaf/hard of hearing as a screening for additional disabilities. Early Hum Dev. 2013 May;89(5):295-300.
Wiley S, Meinzen-Derr J,Stremel-Thomas K, Schalock M, Bashinksi S, Ruder C. Outcomes for children with deaf-blindness with cochlear implants: a multisite observational study. Otol Neurotol. 2013 Apr;34(3):507-15.
Wiley S, Arjmand E, Jareenmeinzen-Derr, Dixon M. Findings from Multidisciplinary Evaluation of Children with Permanent Hearing Loss. Int J Pediatr Otorhinolaryngol. 2011 Aug;75(8):1040-4.
Meinzen-Derr J, Wiley S, Grether S, Choo DI. Children with cochlear implants and developmental disabilities: a language skills study with developmentally matched hearing peers. Res Dev Disabil. 2011 Mar-Apr;32(2):757-67.
Meinzen-Derr J, Wiley S, Choo DI. Impact of Early Intervention on Expressive and Receptive Language Development among Young Children with Permanent Hearing Loss. Am Ann Deaf. 2011 Winter;155(5): 580-91.
Wiley S, Meinzen-Derr J. Access to cochlear implant candidacy evaluations: who is not making it to the team evaluations. Int J Audiol. 2009 Feb;48(2):74-9.
Wiley S, Choo D, Meinzen-Derr J, Hilbert L, Greinwald J. GJB2 mutations and additional disabilities in a pediatric cochlear implant population. Int J Pediatr Otorhinolaryngol. 2006 Mar;70(3):493-500.
Network of 12 academic sites to promote collaborative research in the field of developmental and behavioral pediatrics Funding Source: Maternal and Child Health Research Program. Site Principal Investigator. Developmental Behavioral Pediatrics Research Network (DBPNet). 2013–2016. UA3MC20218.
Collaboration between WIC and EHDI to Improve Follow-up of Newborn Hearing Screen. Co-Investigator. National Center on Birth Defects and Developmental Disabilities, Disability Research and Dissemination. 2013–2014.
Partnerships that Promote Integrated, Multidisciplinary Training Models and Increase Healthcare Access for the Ohio Medicaid Population in collaboration with the University of Cincinnati College of Nursing, Family Medicine, and Cincinnati Children's Hospital Medical Center Division of Child Psychiatry. Co-Investigator. 2013–2014.
Early Language and Functional Expectations (LIFE) Study of Infants and Toddlers with Hearing Loss. Co-Investigator. March of Dimes. Ohio Department of Medicaid/Ohio Medicaid Technical Assistance Policy Program (MEDTAPP) Healthcare Access Initiative. 2014–2015.
J. Paul Willging, MD Director, Interdisciplinary Feeding Team, FEES Clinic and the Velopharyngeal Insufficiency Clinic
Director, Interdisciplinary Feeding Team, FEES Clinic and the Velopharyngeal Insufficiency Clinic
Congenital atresia of the ear and pediatric trauma.
Hearing loss issues; cleft lip and palate patients, ear, nose and throat; ENT anomalies
Jay P. Willging, MD, is certified to practice in Ohio and Kentucky. He is a member of the American Board of Otolaryngology.
Dr. Willging enjoys all areas of otolaryngology and has a special interest in congenital atresia of the ear and pediatric trauma.
A member of several multi-disciplinary teams, the Cincinnati Children's Hospital Medical Center Craniofacial Team, the Velopharyngeal Function and Velopharyngeal Dysfunction (Insufficiency) Clinic and the Functional Endoscopic Evaluation of Swallow Clinic, he is highly respected for his expertise.
The Craniofacial Team brings together Pediatric Otolaryngology -- Head and Neck Surgery, Plastic Surgery, Oral Surgery, Pediatric Dentistry and Orthodontics, Child Psychology, Human Genetics, Speech Pathology and Nutrition to extensively evaluate and manage children with cleft lip and cleft palate issues, as well as other children with craniofacial anomalies.
The Velopharyngeal Function and Velopharyngeal Dysfunction (Insufficiency) Clinic brings together Otolaryngology, Speech-Language Pathology and Human Genetics to evaluate children with complex speech difficulties.
The Fiberoptic Endoscopic Evaluation of Swallow Clinic (FEES) brings together Otolaryngology and Speech-Language Pathology to evaluate children with swallowing disorders.
In addition to ongoing research, Dr. Willging performs surgery and sees children at numerous locations, making treatment more convenient and accessible for his patients.
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