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The Ear and Hearing Center is home to specialists with a wide variety of backgrounds and areas of focus. As a team, this diversity makes us better prepared to care for your child’s unique needs. Learn more about our faculty and staff.
Daniel I. Choo, MD Director, Division of Pediatric Otolaryngology - Head and Neck Surgery 513-636-4355 firstname.lastname@example.org
Director, Division of Pediatric Otolaryngology - Head and Neck Surgery
Professor, UC Department of Pediatrics
UC Department of Otolaryngology – Head and Neck Surgery
Diagnosis and management of children with hearing loss; pediatric cochlear implantation; surgery for congenital ear abnormalities; hearing restoration surgery; disorders of the endolymphatic system of the inner ear (e.g., Meniere's Disease).
Daniel Choo, MD, obtained his medical degree from the State University of New York Health Science Center at Syracuse, NY, and completed his otolaryngology residency training in Syracuse.
Dr. Choo completed fellowships in otology / neurotology at the Ear Research Foundation in Sarasota, Florida and the Neurotology Branch of the National Institute on Deafness and Other Communication Disorders (NIDCD), National Institutes of Health, Bethesda, MD.
MD: State University of New York Health Science Center at Syracuse, Syracuse, NY, 1989.
Fellowship: Neuro-otology, Ear Research Foundation, Sarasota, Fla., 1995; Molecular and Developmental Biology of the Inner Ear, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, 1999.
Residency: State University of New York Health Science Center at Syracuse, Syracuse, NY, 1994.
Certification: American Board of Otolaryngology, 1995.
John H. Greinwald Jr., MD, FAAP
Sun GH, Harmych BM, Dickson JM, Gonzalez Del Rey JA, Myer CM 3rd, Greinwald JH Jr. Characteristics of children diagnosed as having coagulopathies following posttonsillectomy bleeding. Arch Otolaryngol Head Neck Surg. 2011 Jan;137(1):65-8.
Johnson RF, Cohen AP, Guo Y, Schibler K, Greinwald JH. Genetic mutations and aminoglycoside-induced ototoxicity in neonates. Otolaryngol Head Neck Surg. 2010 May;142(5):704-7.
Hopkins BS, Johnson KE, Ksiazek JM, Sun G, Greinwald JH, Rutter M. H1N1 influenza A presenting as bacterial tracheitis. Otolaryngol Head Neck Surg. 2010 Apr;142(4):612-4.
Kothiyal P, Cox S, Ebert J, Husami A, Kenna MA, Greinwald JH, Aronow BJ, Rehm HL. High-throughput detection of mutations responsible for childhood hearing loss using resequencing microarrays. BMC Biotechnol. 2010 Feb 10;10:10.
Propst EJ, Greinwald JH, Schmithorst V. Neuroanatomic differences in children with unilateral sensorineural hearing loss detected using functional magnetic resonance imaging. Arch Otolaryngol Head Neck Surg. 2010 Jan;136(1):22-6.
Kothiyal P, Cox S, Ebert J, Aronow BJ, Greinwald JH, Rehm HL. An overview of custom array sequencing. Curr Protoc Hum Genet. 2009 Apr;Chapter 7:Unit 7.17.
Lee KH, Larson DA, Shott G, Rasmussen B, Cohen AP, Benton C, Halsted M, Choo D, Meinzen-Derr J, Greinwald JH Jr. Audiologic and temporal bone imaging findings in patients with sensorineural hearing loss and GJB2 mutations. Laryngoscope. 2009 Mar;119(3):554-8.
Greinwald J Jr, Cohen AP, Hemanackah S, Azizkhan RG. Massive lymphatic malformations of the head, neck, and chest. J Otolaryngol Head Neck Surg. 2008 Apr;37(2):169-73.
Schraff SA, Schleiss MR, Brown DK, Meinzen-Derr J, Choi KY, Greinwald JH, Choo DI. Macrophage inflammatory proteins in cytomegalovirus-related inner ear injury. Otolaryngol Head Neck Surg. 2007 Oct;137(4):612-8.
Vijayasekaran S, Halsted MJ, Boston M, Meinzen-Derr J, Bardo DM, Greinwald J, Benton C. When is the vestibular aqueduct enlarged? A statistical analysis of the normative distribution of vestibular aqueduct size. AJNR Am J Neuroradiol. 2007 Jun-Jul;28(6):1133-8.
Min-Xin Guan, PhD 513-636-3337 email@example.com
Adjunct Professor, UC Department of Pediatrics
Mitochondrial biogenesis, cellular and molecular biology of mitochondrial disorders, especially in hearing loss and neuromuscular disorders.
Guan MX. Mitochondrial 12S rRNA mutations associated with aminoglycoside ototoxicity. Mitochondrion. 2011 Mar;11(2):237-45.
Li R, Guan MX. Human mitochondrial leucyl-tRNA synthetase corrects mitochondrial dysfunctions due to the tRNALeu(UUR) A3243G mutation, associated with mitochondrial encephalomyopathy, lactic acidosis, and stroke-like symptoms and diabetes. Mol Cell Biol. 2010 May;30(9):2147-54.
Wang X, Yan Q, Guan MX. Combination of the loss of cmnm5U34 with the lack of s2U34 modifications of tRNALys, tRNAGlu, and tRNAGln altered mitochondrial biogenesis and respiration. J Mol Biol. 2010 Feb 5;395(5):1038-48.
Qian Y, Guan MX. Interaction of aminoglycosides with human mitochondrial 12S rRNA carrying the deafness-associated mutation. Antimicrob Agents Chemother. 2009 Nov;53(11):4612-8.
Li R, Liu Y, Li Z, Yang L, Wang S, Guan MX. Failures in mitochondrial tRNAMet and tRNAGln metabolism caused by the novel 4401A>G mutation are involved in essential hypertension in a Han Chinese Family. Hypertension. 2009 Aug;54(2):329-37.
Wang X, Yan Q, Guan MX. Mutation in MTO1 involved in tRNA modification impairs mitochondrial RNA metabolism in the yeast Saccharomyces cerevisiae. Mitochondrion. 2009 Jun;9(3):180-5.
Wang X, Lu J, Zhu Y, Yang A, Yang L, Li R, Chen B, Qian Y, Tang X, Wang J, Zhang X, Guan MX. Mitochondrial tRNAThr G15927A mutation may modulate the phenotypic manifestation of ototoxic 12S rRNA A1555G mutation in four Chinese families. Pharmacogenet Genomics. 2008 Dec;18(12):1059-70.
Wang X, Yan Q, Guan MX. Deletion of the MTO2 gene related to tRNA modification causes a failure in mitochondrial RNA metabolism in the yeast Saccharomyces cerevisiae. FEBS Lett. 2007 Sep 4;581(22):4228-34.
Guan MX, Yan Q, Li X, Bykhovskaya Y, Gallo-Teran J, Hajek P, Umeda N, Zhao H, Garrido G, Mengesha E, Suzuki T, del Castillo I, Peters JL, Li R, Qian Y, Wang X, Ballana E, Shohat M, Lu J, Estivill X, Watanabe K, Fischel-Ghodsian N. Mutation in TRMU related to transfer RNA modification modulates the phenotypic expression of the deafness-associated mitochondrial 12S ribosomal RNA mutations. Am J Hum Genet. 2006 Aug;79(2):291-302.
Li R, Qu J, Zhou X, Tong Y, Hu Y, Qian Y, Lu F, Mo JQ, West CE, Guan MX. The mitochondrial tRNA(Thr) A15951G mutation may influence the phenotypic expression of the LHON-associated ND4 G11778A mutation in a Chinese family. Gene. 2006 Jul 5;376(1):79-86.
Scott K. Holland, PhD Director, Pediatric Neuroimaging Research Consortium 513-636-7565 firstname.lastname@example.org
Director, Pediatric Neuroimaging Research Consortium
Director, Research in Patient Services
Director, Reading and Literacy Discovery Center
UC Department of Radiology
Advanced neuroimaging applications of MRI in pediatrics; functional MRI of language, hearing and neuroplasticity following brain injury; brain development.
Scott Holland is a physicist by training with a BS (1980) in Physics from Muhlenberg College, Allentown, PA. and an MS (1982) and PhD (1985) in Engineering and Applied Science from Yale University.
After a year (1985-86) as a Research Engineer with the Electromagnetic Sciences Laboratory at Stanford Research Institute (SRI International), Menlo Park, CA, Scott returned to the Yale School of Medicine as a post-doctoral fellow (1986-88) and later as an assistant professor (1988-94) of Diagnostic Radiology.
He joined the faculty of the University of Cincinnati College of Medicine in 1994 as associate professor of Radiology and Pediatrics and served as scientific director of the Imaging Research Center at Children's Hospital Medical Center until 2003.
In 2005 he founded the Pediatric Neuroimaging Research Consortium with the Department of Pediatric Radiology and the Divisions of Neurosurgery, Neurology, Psychiatry and Biostatistics at Cincinnati Children's. The PNRC continues to grow and currently consists of 8 full-time faculty members engaged in research using a broad range of neuroimaging techniques to study the developing brain under the influence of diseases of childhood. From 2009 to 2013, Scott led the Communication Sciences Research Center as its founding director. Currently he is serving as director of the new Division of Research in Patient Services.
His research currently focuses on pediatric neuroimaging applications of MRI, MEG and EEG methods; including perfusion MRI, functional MRI, and image processing methods, to study development of the neural circuitry of hearing, language, speech and reading capabilities through childhood. His discoveries regarding changes in brain activity and connectivity during typical childhood development and under the influence of neurological disorders have been influential in our understanding of neuroplasticity and reorganization of the developing brain in response to injury.
Res Hafeman DM, Bebko G, Bertocci MA, Fournier JC, Bonar L, Holland SK, Phillips ML. Abnormal Deactivation of the Inferior Frontal Gyrus During Implicit Emotion Processing in Youth with Bipolar Disorder: Attenuated by Medication. J Psychiatr Res. 2014;58:129-136.
Horowitz-Kraus T, Cicchino N, Amiel M, Holland SK, Breznitz Z. Reading Improvement in English- and Hebrew-Speaking Children with Reading Difficulties after Reading Acceleration Training. Ann Dyslexia. 2014;64(3):183-201.
Jacola LM, Byars AW, Hickey F, Vannest J, Holland SK, Schapiro MB. Functional Magnetic Resonance Imaging of Story Listening in Adolescents and Young Adults with Down Syndrome: Evidence for Atypical Neurodevelopment. J Intellect Disabil. 2014;58(10):892-902.
Bertocci MA, Bebko G, Olino T, Fournier J, Hinze AK, Bonar L, Phillips ML. Behavioral and Emotional Dysregulation Trajectories Marked by Prefrontal-Amygdala Function in Symptomatic Youth. Psychol Med. 2014;44(12),:2603-2615.
Horowitz-Kraus T, Wang Y, Plante E, Holland SK. Involvement of the Right Hemisphere in Reading Comprehension: A Dti Study. Brain Res. 2014;1582:34-44.
Schmithorst VJ, Vannest J, Lee G, Hernandez-Garcia L, Plante E, Rajagopal A, The CMIND Authorship Consortium. Evidence That Neurovascular Coupling Underlying the Bold Effect Increases with Age During Childhood. Hum Brain Mapp. 2014.
Vannest J, Rajagopal A, Cicchino ND, Franks-Henry J, Simpson SM, Lee G, The CMIND Authorship Consortium. Factors Determining Success of Awake and Asleep Magnetic Resonance Imaging Scans in Nonsedated Children. Neuropediatrics. 2014.
*Farah R, Schmithorst VJ, Keith RW, Holland SK. Altered White Matter Microstructure Underlies Listening Difficulties in Children Suspected of Auditory Processing Disorders: A Dti Study. Brain and Behavior. 2014;4(4):531-543.
Rajagopal A, Byars A, Schapiro M, Lee GR, Holland SK. Success Rates for Functional MR Imaging in Children. AJNR Am J Neuroradiol. 2014.
Wilke M, Rose DF, Holland SK, Leach JL. Multidimensional Morphometric 3d MRI Analyses for Detecting Brain Abnormalities in Children: Impact of Control Population. Hum Brain Mapp. 2014;35(7):3199-3215.
Reading & Literacy Discovery Center Tier 3. Principal Investigator. Schroth Charitable Trust. Jan 14 - Dec 16.
Developing a Reading and Literacy Discovery Center. Principal Investigator. Farmer Family Foundation. Nov 13 - Jun 15.
Developing a Reading and Literacy Discovery Center. Principal Investigator. Fischer Family Foundation. Jan 13 - Dec 15.
Structural and Network-Function Correlates of Fragmented Early Life Across Species. Consultant. National Institutes of Health. Jun 13 - Apr 18. 1P50MH096889-01.
Longitudinal Assessment of Manic Symptoms 2 (LAMS2). Collaborator. National Institutes of Health. Oct 10 - Sept 15. R01- MH073816.
Imaging the Effect of Centrotemporal Spikes and Seizures on Language in Children. Collaborator. National Institutes of Health. Jul 11 - Jun 16. R01 NS065840-01A1.
Gayle Riemer, MA, CCC-A, F-AAA
Audiologist III, Division of Audiology 513-636-4236 email@example.com
Susan E. Wiley, MD Co-Director, Division of Developmental and Behavioral Medicine 513-636-4611 firstname.lastname@example.org
Co-Director, Division of Developmental and Behavioral Medicine
Pediatrician, Division of Developmental and Behavioral Pediatrics
UC Department of Otolaryngology, Head & Neck Surgery
Pediatric hearing loss; dual sensory impairment; deaf/hard of hearing plus; children with neurodevelopmental disabilities
Dr. Wiley has served on state and national organizations to improve the early hearing detection and intervention activities across the United States. She served as the faculty chair on Improving Hearing Screening and Information Systems Initiative for the National Initiative for Children’s Healthcare Quality (2011-2013) and is a taskforce member with the American Academy of Pediatrics to identify strategies to improve linkage of Universal Newborn Hearing Screening (UNHS) to the medical home.
MD: University of Cincinnati, OH, 1994.
Residency: Pediatrics, Children's Hospital Medical Center of Cincinnati, OH.
Fellowship: Developmental Pediatrics, Cincinnati Center for Developmental Disorders, Cincinnati, OH.
Certification: Pediatrics, 1997.
Certification: Developmental-Behavioral Pediatrics, 2002.
Meinzen-Derr J, Wiley S, Grether S, Phillips J, Choo D, Hibner J, Barnard H. Functional communication of children who are deaf or hard-of-hearing. J Dev Behav Pediatr. 2014 Apr;35(3):197-206.
Wiley S, Gustafson S, Rozniak J. Needs of parents of children who are deaf/hard of hearing with autism spectrum disorder. J Deaf Stud Deaf Educ. 2014 Jan;19(1):40-9.
Meinzen-Derr J, Wiley S, Bishop S, Manning-Courtney P, Choo D, Gustafson S, Murray D. Autism spectrum disorders in children who are deaf or hard of hearing. Int J Pediatr Otorhinolaryngol. 2014 Jan;78(1):112-8.
Wiley S, Meinzen-Derr J. Use of the ages and stages questionnaire in young children who are deaf/hard of hearing as a screening for additional disabilities. Early Hum Dev. 2013 May;89(5):295-300.
Wiley S, Meinzen-Derr J,Stremel-Thomas K, Schalock M, Bashinksi S, Ruder C. Outcomes for children with deaf-blindness with cochlear implants: a multisite observational study. Otol Neurotol. 2013 Apr;34(3):507-15.
Wiley S, Arjmand E, Jareenmeinzen-Derr, Dixon M. Findings from Multidisciplinary Evaluation of Children with Permanent Hearing Loss. Int J Pediatr Otorhinolaryngol. 2011 Aug;75(8):1040-4.
Meinzen-Derr J, Wiley S, Grether S, Choo DI. Children with cochlear implants and developmental disabilities: a language skills study with developmentally matched hearing peers. Res Dev Disabil. 2011 Mar-Apr;32(2):757-67.
Meinzen-Derr J, Wiley S, Choo DI. Impact of Early Intervention on Expressive and Receptive Language Development among Young Children with Permanent Hearing Loss. Am Ann Deaf. 2011 Winter;155(5): 580-91.
Wiley S, Meinzen-Derr J. Access to cochlear implant candidacy evaluations: who is not making it to the team evaluations. Int J Audiol. 2009 Feb;48(2):74-9.
Wiley S, Choo D, Meinzen-Derr J, Hilbert L, Greinwald J. GJB2 mutations and additional disabilities in a pediatric cochlear implant population. Int J Pediatr Otorhinolaryngol. 2006 Mar;70(3):493-500.
Network of 12 academic sites to promote collaborative research in the field of developmental and behavioral pediatrics Funding Source: Maternal and Child Health Research Program. Site Principal Investigator. Developmental Behavioral Pediatrics Research Network (DBPNet). 2013–2016. UA3MC20218.
Collaboration between WIC and EHDI to Improve Follow-up of Newborn Hearing Screen. Co-Investigator. National Center on Birth Defects and Developmental Disabilities, Disability Research and Dissemination. 2013–2014.
Partnerships that Promote Integrated, Multidisciplinary Training Models and Increase Healthcare Access for the Ohio Medicaid Population in collaboration with the University of Cincinnati College of Nursing, Family Medicine, and Cincinnati Children's Hospital Medical Center Division of Child Psychiatry. Co-Investigator. 2013–2014.
Early Language and Functional Expectations (LIFE) Study of Infants and Toddlers with Hearing Loss. Co-Investigator. March of Dimes. Ohio Department of Medicaid/Ohio Medicaid Technical Assistance Policy Program (MEDTAPP) Healthcare Access Initiative. 2014–2015.
J. Paul Willging, MD Director, Interdisciplinary Feeding Team, FEES Clinic and the Velopharyngeal Insufficiency Clinic 513-636-4355 email@example.com
Director, Interdisciplinary Feeding Team, FEES Clinic and the Velopharyngeal Insufficiency Clinic
Congenital atresia of the ear and pediatric trauma.
Jay P. Willging, MD, is certified to practice in Ohio and Kentucky. He is a member of the American Board of Otolaryngology.
Dr. Willging enjoys all areas of otolaryngology and has a special interest in congenital atresia of the ear and pediatric trauma.
A member of several multi-disciplinary teams, the Cincinnati Children's Hospital Medical Center Craniofacial Team, the Velopharyngeal Function and Velopharyngeal Dysfunction (Insufficiency) Clinic and the Functional Endoscopic Evaluation of Swallow Clinic, he is highly respected for his expertise.
The Craniofacial Team brings together Pediatric Otolaryngology -- Head and Neck Surgery, Plastic Surgery, Oral Surgery, Pediatric Dentistry and Orthodontics, Child Psychology, Human Genetics, Speech Pathology and Nutrition to extensively evaluate and manage children with cleft lip and cleft palate issues, as well as other children with craniofacial anomalies.
The Velopharyngeal Function and Velopharyngeal Dysfunction (Insufficiency) Clinic brings together Otolaryngology, Speech-Language Pathology and Human Genetics to evaluate children with complex speech difficulties.
The Fiberoptic Endoscopic Evaluation of Swallow Clinic (FEES) brings together Otolaryngology and Speech-Language Pathology to evaluate children with swallowing disorders.
In addition to ongoing research, Dr. Willging performs surgery and sees children at numerous locations, making treatment more convenient and accessible for his patients.
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