• Clinical Research Involves Multiple Disciplines

    Clinical researchers at the Heart Institute explore a wide variety of topics related to cardiovascular research. We merge the diverse activities of clinical care, research, education, operations and outcomes improvement to drive the exchange of information between bench and bedside and facilitate each discipline’s ability to respond to the other. The result is world-class pediatric heart care.

  • Areas of Research

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    Cincinnati Children’s is one of only eight core sites within the Pediatric Heart Network (PHN) across the United States and Canada. PHN protocols conducted at Cincinnati Children’s include the Marfan trial, the Infant Single Ventricle (ISV) trial, the Single Ventricle Reconstruction (SVR) trial and the Single Ventricle Reconstruction Extension (SVRII) trial.
    Our researchers also investigate various cardiovascular problems, such as hypertension, obesity-related complications and cholesterol to understand their origins and develop more effective therapies. This broad-reaching work involves collaboration with members of the divisions of Cardiology, Endocrinology, Nephrology, Pulmonology, Radiology, Biostatistics and Epidemiology, and investigators at the University of Cincinnati.

    Our cardiac MRI research focuses on early detection of heart muscle disease, particularly in children and adolescents with muscular dystrophy. Problems such as left ventricle hypertrophy are difficult to identify early in these children; physicians often don’t identify symptoms until the condition is advanced. Through our research into MRI techniques, we hope to identify these diseases in their early, less-evident stages.

    As survival rates in children with chronic health conditions have improved, clinicians have begun to recognize quality of life as an important health outcome. Investigators at Cincinnati Children’s are leaders in the field of quality-of-life measurement in children with heart disease. The measures we developed and utilize here not only include disease-specific measures, with greater clinical utility in assessing concerns that are particular to this patient population, but also include parent-proxy and child self-report measures. Both are essential to quality of life assessment, given the observed lack of significant agreement between proxy- and self-report cross-informant variance, demonstrated in multiple pediatric studies.

    Read more about outcomes research being conducted at the Heart Institute.

    Faculty members from the Cardiac Intensive Care Unit (CICU) collaborate with investigators from around North America as part of several multicenter studies. The topics covered by our research include evaluating the incidence of acute kidney injury after cardiopulmonary bypass, identifying biomarkers that could indicate kidney injury in its earliest stages and long-term outcomes research that follows patients long after their stays in the CICU.

    Other areas currently under investigation include the evaluation of the amino acid citrulline to prevent postoperative pulmonary hypertension and the evaluation of novel non-invasive ways to measure cardiac output in pediatric cardiac patients.

    The Fetal Heart Program at Cincinnati Children’s is dedicated to improving the care and outcomes of fetuses with a variety of cardiovascular conditions. Clinical research is central to our mission to improving outcomes. Research focuses on hypothesis-driven clinical and animal research studies, and is aimed at characterization of cardiovascular abnormalities in a variety of pathologic fetal conditions.

    Read more about the Fetal Heart Program.

  • Translational Research

    Translational research – the move from bench to bedside – is a core part of research at the Heart Institute at Cincinnati Children’s.

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