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The Heart Institute is home to specialists with a wide variety of backgrounds and areas of focus. As a team, this diversity makes us better prepared to care for your child’s unique needs. Learn more about our faculty and staff.
Andrew Redington, MD Executive Co-Director, Heart Institute; Chief, Pediatric Cardiology firstname.lastname@example.org
Executive Co-Director, Heart Institute; Chief, Pediatric Cardiology
Professor, UC Department of Pediatrics
Dr. Redington comes to Cincinnati Children’s from The Hospital for Sick Children in Toronto, Ontario. His research interests include ventricular function, integrated physiology of congenital heart disease, and ischemic preconditioning. Dr. Redington has written more than 300 peer-reviewed publications, more than 30 book chapters, and has co-edited seven textbooks. He currently holds over 15 US and international patents.
Working with colleagues throughout the Heart Institute, his plans include building on the remarkable developments achieved in the recent past to establish a world-leading multidisciplinary team providing the highest quality clinical care and practice-changing research for children and adults with congenital heart disease.
Medical School: University of London.
Research Training: Doctorate of Medicine, University of London.
Fellowship: Adult cardiology, pediatric cardiology, The Royal Brompton Hospital, London, England.
Li J, Rohaila S, Gelber N, Rutka J, Sabah N, Gladstone R, Wei C, Kharbanda R, Redington AN. MicroRNA-144 is a circulating effector of remote ischemic preconditioning. Basic Research in Cardiology 2014: 109 (5): pp 423. (Sept)
Burns KM, Byrne BJ, Gelb BD, Kuhn B, Leinwand LA, Mital S, Pearson GD, Rodefeld M, Rossano JW, Stauffer BL, Taylor MD, Towbin JA, Redington AN. New mechanistic and therapeutic targets for pediatric heart failure: report from a national heart, lung, and blood institute working group. Circulation 2014: 130 (1): pp 79-86. (July)
Friedberg MK, Redington AN. Right versus left ventricular failure: differences, similarities, and interactions. Circulation 2014: 129 (9): pp 1033-1044. (Mar)
Friedberg MK, Cho MY, Li J, Assad RS, Sun M, Rohailla S, Honjo O, Apitz C, Redington AN. Adverse biventricular remodeling in isolated right ventricular hypertension is mediated by increased TGFβ1 signaling and is abrogated by angiotensin receptor blockade. American Journal of Respirology Cell Molecular Biology 2013: 49 (6): pp 1019-1028. (Dec)
Roche SL, Redington AN. Right ventricle: wrong targets? Another blow for pharmacotherapy in congenital heart diseases. Circulation 2013: 127 (3): pp 314-316. (Jan)
Hahn CD, Manlhiot C, Schmidt MR, Nielsen TT, Redington AN. Remote ischemic per-conditioning: A novel therapy for evolving stroke? Stroke 2011: 42 (10) pp 2960-2962.
Jean-St-Michel E, Manlhiot C, Li J, Tropak M, Michelsen MM, Schmidt MR, McCrindle BW, Slievert G, Wells GD, Redington AN. Remote Ischemic Preconditioning improves maximal performance in elite athletes. Medicine & Science of Sports & Exercise 2011: 43 (7): pp 1280-1286.
Wei M, Xin P, Li Y, Li J, Ma S, Wang L, Liu M, Li J, Zhu W, Redington AN. Repeated remote ischemic postconditioning protects against adverse left ventricular remodeling and improves survival in a rat model of myocardial infarction. Circulation Research 2011: 108 (10): pp 1220-1225.
Roche SL, Vogel M, Pitkanen O, Grant B, Slorach C, Fackoury C, Stephens D, Smallhorn J, Benson LN, Kantor PF, Redington AN. Isovolumic acceleration at rest and during exercise in children normal values for the left ventricle and first non-invasive demonstration of exercise-induced force-frequency relationships. Journal of American College of Cardiology 2011: 57 (9): pp 1100-1107.
Botker HE, Kharbanda R, Schmidt MR, Bottcher M, Kaltoft AK, Terkelsen CJ, Munk K, Anderson NH, Hansen TM, Trautner S, Lassen JF, Christiansen EH, Krusell LR, Kristensen SD, Thuesen L, Nielsen SS, Rehling M, Sorensen HT, Redington AN, Neilseu TT: Remote ischaemic conditioning before hospital admission, as a complement to angioplasty, and effect on myocardial salvage in patients with acute myocardial infarction: a randomized trial. Lancet 2010: 375 (9716): pp 727-734.
Jeffrey Robbins, PhD Director and Endowed Chair, Molecular Cardiovascular Biology 513-636-8098 email@example.com
Director and Endowed Chair, Molecular Cardiovascular Biology
Executive Co-Director, Heart Institute
Associate Chair, Children's Hospital Research Foundation
Structure function relationships for the contractile proteins; cardiac-specific gene manipulation in transgenic rabbits; the contractile protein myosin and human heart failure; molecular studies of human valve disease
Visit the Robbins Lab.
Gupta MK, Robbins J. Post-translational control of cardiac hemodynamics through myosin binding protein C. Pflugers Arch: European journal of physiology. 2014 Feb;466(2):231-6.
Mun JY, Previs MJ, Yu HY, Gulick J, Tobacman LS, Beck Previs S, Robbins J, Warshaw DM, Craig R. Myosin-binding protein C displaces tropomyosin to activate cardiac thin filaments and governs their speed by an independent mechanism. Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):2170-5.
Sandri M, Robbins J. Proteotoxicity: An underappreciated pathology in cardiac disease. J Mol Cell Cardiol. 2014 Jun;71c:3-10.
Wang X, Robbins J. Proteasomal and lysosomal protein degradation and heart disease. J Mol Cell Cardiol. 2014 Jun;71c:16-24.
James J, Robbins J. Ablating a cardiac protein: Causality at last. Circ Res. 2013;112:1415-1419.
Razzaque MA, Gupta M, Osinska H, Gulick J, Blaxall BC, Robbins J. An endogenously produced fragment of cardiac myosin-binding protein C is pathogenic and can lead to heart failure. Circ Res. 2013 Aug 16;113(5):553-61.
Gupta MK, Gulick J, James J, Osinska H, Lorenz JN, Robbins J. Functional dissection of myosin binding protein C phosphorylation. J Mol Cell Cardiol. 2013;64C:39-50.
Bhuiyan MS, Pattison JS, Osinska H, James J, Gulick J, McLendon PM, Hill JA, Sadoshima J, Robbins J. Enhanced autophagy ameliorates cardiac proteinopathy. J Clin Invest. 2013;123(12):5284-97.
Pattison JS, Robbins J. Desmin and heart disease. In: Kavallaris M, ed. Cytoskeleton and human disease. New York, NY: Humana Press; 2012:411-424.
Bhuiyan MS, Gulick J, Osinska H, Gupta M, Robbins J. Determination of the critical residues responsible for cardiac myosin binding protein C's interactions. J Mol Cell Cardiol. 2012;53:838-847.
Cardiac Signaling in the Normal and Abnormal Heart. Principal Investigator. National Heart, Lung, and Blood Institute. Sep 2013-May 2018. #P01 HL69779.
Proteotoxicity: an underappreciated factor in cardiac disease. North American Coordinator. Leducq Transatlantic Alliance For Cardiovascular Disease. 2011-2016.
James S. Tweddell, MD Executive Co-Director, Heart Institute 513-803-8824 firstname.lastname@example.org
Surgical Director, Heart Institute
Professor, UC Department of Surgery
Surgical emphases include congenital heart surgery in neonates, infants, children, teenagers and adults. Heart transplantation and mechanical circulatory support.
Dr. Tweddell leads the Heart Institute’s surgical team providing unparalleled surgical care and innovation for our patients and their families. Over the last 20 years, he built the pediatric cardiothoracic surgery program at the Medical College of Wisconsin, where he held the S. Bert Litwin Chair for Cardiothoracic Surgery position, served as medical director of pediatric cardiothoracic surgery at Children’s Hospital of Wisconsin and professor and chief for the Division of Cardiothoracic Surgery. Dr. Tweddell has an extensive list of vital research contributions, having authored more than 125 peer reviewed articles, published numerous books, chapters, invited reviews and editorials, and serving on multiple editorial boards and national committees.
Dr. Tweddell is the elite surgeon of his generation and has earned a worldwide reputation for outstanding clinical results based on team contributions to his outcomes. He decreased mortality following the Norwood procedure through the use of venous saturation monitoring and afterload reduction. In addition, Dr. Tweddell reduced interstage mortality of a single ventricle patient through the development of a home monitoring program.
MD: University of Cincinnati, Cincinnati, OH, 1985.
Residency: Intern and Second Year Resident in General Surgery, New York Medical Center, New York, NY, 1987.
Residency: Research Fellow in Cardiothoracic Surgery, Washington University Medical Center, St. Louis, MO, 1989.
Residency: Senior Resident and Chief Resident in General Surgery, Washington University Medical Center, St. Louis, MO, 1991.
Residency: Resident in Cardiothoracic Surgery, Washington University Medical Center, St. Louis, MO, 1993.
Fellowship: Fellow in Pediatric Cardiothoracic Surgery, Washington University Medical Center, St. Louis, MO, 1993.
Jacobs JP, O'Brien SM, Pasquali SK, Gaynor JW, Mayer JE Jr, Karamlou T, Welke KF, Filardo G, Han JM, Kim S, Quintessenza JA, Pizarro C, Tchervenkov CI, Lacour-Gayet F, Mavroudis C, Backer CL, Austin EH 3rd, Fraser CD, Tweddell JS, Jonas RA, Edwards FH, Grover FL, Prager RL, Shahian DM, Jacobs ML. The Society of Thoracic Surgeons Congenital Heart Surgery Database Mortality Risk Model: Part 2-Clinical Application. Ann Thorac Surg. 2015 Aug 3.
Tweddell JS. The Atrial Level Switch Operation: Lessons Old and New. Circulation. 2015 Jul 16.
Niebler RA, Shah TK, Mitchell ME, Woods RK, Zangwill SD, Tweddell JS, Berger S, Ghanayem NS. Ventricular Assist Device in Single-Ventricle Heart Disease and a Superior Cavopulmonary Anastomosis. Artif Organs. 2015 Jul 6.
Jacobsen RM, Earing MG, Hill GD, Barnes M, Mitchell ME, Woods RK, Tweddell JS. The Externally Supported Ross Operation: Early Outcomes and Intermediate Follow-Up. Ann Thorac Surg. 2015 Aug;100(2):631-8.
Ginde S, Lam J, Hill GD, Cohen S, Woods RK, Mitchell ME, Tweddell JS, Earing MG. Long-term outcomes after surgical repair of complete atrioventricular septal defect. J Thorac Cardiovasc Surg. 2015 Aug;150(2):369-74.
Buelow MW, Earing MG, Hill GD, Cohen SB, Bartz PJ, Tweddell JS, Ginde S. Tricuspid repair at pulmonary valve replacement does not alter outcomes in tetralogy of Fallot. Ann Thorac Surg. 2015 Mar;99(3):899-904.
Cox DA, Ginde S, Tweddell JS, Earing MG. Outcomes of a hepatitis C screening protocol in at-risk adults with prior cardiac surgery. World J Pediatr Congenit Heart Surg. 2014 Oct;5(4):503-6.
Samyn MM, Plymale JM, Cousineau AJ, Tweddell JS. TAPVR in a kindergartner presenting with fatigue. BMJ Case Rep. 2014 Oct 9;2014.
McCrindle BW, Li JS, Manlhiot C, Tweddell JS, Giglia TM, Massicotte MP, Monagle P, Krishnamurthy R, Mahaffey KW, Michelson AD, Verdun N, Almond CS, Newburger JW, Brandão LR, Esmon CT, Manco-Johnson MJ, Ichord R, Ortel TL, Chan AK, Portman R, Rose M, Strony J, Kaltman JR. Challenges and priorities for research: a report from the National Heart, Lung, and Blood Institute (NHLBI)/National Institutes of Health (NIH) Working Group on thrombosis in pediatric cardiology and congenital heart disease. Circulation. 2014 Sep 30;130(14):1192-203.
Mitchell ME, Rumman N, Chun RH, Rao A, Martin T, Beste DJ, Berens RJ, Parakininkas DE, Ghanayem NS, Hubert MJ, Uhing M, Simpson P, Sato TT, Tweddell JS, Kerschner JE. Anterior tracheal suspension for tracheobronchomalacia in infants and children. Ann Thorac Surg. 2014 Oct;98(4):1246-53.
PumpKIN Trial. Principle Surgical Investigator. National Institutes of Health. 2013-ongoing.
Targeted, Highly Sensitive, Non-Invasive Cardiac Transplant Rejection Monitoring. Co-Principal Investigator. National Institutes of Health. 2013-2018.
Berlin Heart Post Approval Study. Co-Principal Investigator. Berlin Heart Inc. Aug 2013-ongoing.
Thomas R. Kimball, MD Medical Director, Heart Institute 513-636-8270 email@example.com
Medical Director, Heart Institute
Congential heart disease; echocardiography; cardiac imaging
Thomas R. Kimball, MD, is a professor of pediatrics with the University of Cincinnati College of Medicine and is currently the medical director of the Heart Institute at Cincinnati Children's Hospital Medical Center.
A native of California, Dr. Kimball graduated with distinction and honors from Stanford University. He earned his medical degree from New York University, New York, NY. He completed his pediatric internship and residency at Children's Hospital of Los Angeles and his pediatric cardiology fellowship at Cincinnati Children's Hospital Medical Center.
Dr. Kimball has been an attending staff member of the Division of Cardiology at Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine since 1988.
Dr. Kimball's academic interests relate to echocardiography and he has made numerous scholarly contributions in the field of ventricular function utilizing echocardiography, particularly in the field of hypertension and obesity.
He has established collaborative relationships with basic scientists at the University of Cincinnati College of Medicine using echocardiography to evaluate phenotypes of transgenic mice, including embryonic mice.
Dr. Kimball has been active in the cardiology community. He is a member of the American Society of Echocardiography, American Heart Association, American Academy of Pediatrics, American College of Cardiology and an investigator in the NIH Pediatric Heart Network.
He was also a member of the first Family Advisory Council at Cincinnati Children's and received the 2006 Family Advisory Council Award of Excellence.
In 2010, he was made the medical director of the Heart Institute at Cincinnati Children's.
BS: Stanford University with Honors and Distinction, Stanford, CA, 1978.
MD: New York University School of Medicine, New York City, NY, 1982.
Residency: Children's Hospital of Los Angeles, Los Angeles, CA, 1985.
Fellowship: Children's Hospital Medical Center, Cincinnati, OH, 1988.
Certification: Pediatrics, 1986; Pediatric Cardiology, 1991 (recertification, 1997, 2004).
Shah AS, Gao Z, Urbina EM, Kimball TR, Dolan LM. The effects of arterial thickness and stiffness in obese youth. Journal of Clinical Endocrinology Metabolism. 2014 Mar;99(3):1037-43.
Alghamdi M, De Souza AM, White CT, Potts MT, Warady BA, Furth SL, Kimball TR, Potts JE, Sandor GG. Response to: echocardiography assessment of the aorta in children with chronic kidney disease. Pediatric Cardiology. 2014 Jan;35(1):183-4.
Uzark K, King E, Spicer R, Beekman R, Kimball T, Varni J. The clinical utility of health-related quality of life assessment in pediatric cardiology outpatient practice. Congenital Heart Disease. 2013 May;8(3):211-8.
Madueme PC, Khoury PR, Urbina EM, Kimball TR. Predictors of exaggerated exercise-induced systolic blood pressures in young patients after coarctation repair. Cardiology In The Young. 2013 Jun;23(3):416-22.
Alghamdi M, De Souza A, White CT, Potts MT, Warady BA, Furth SL, Kimball T, Potts JE, Sandor GG. Echo-Doppler assessment of the biophysical properties of the aorta in children with chronic kidney disease. Pediatric Cardiology. 2013 Jun;34(5):1218-25.
Urbina EM, Khoury PR, McCoy CE, Dolan LM, Daniels SR, Kimball TR. Triglyceride to HDL-C ratio and increased arterial stiffness in children, adolescents and young adults. Pediatrics. 2013 Apr;131(4):E1082-90.
Shah AS, Urbina EM, Khoury PR, Kimball TR, Dolan LM. Lipids and lipoprotein ratios: Contribution to carotid intima media thickness in adolescents and young adults with type 2 diabetes mellitus. Journal of Clinical Lipidology. 2013 Sept-Oct;7(5):441-445.
Kimball TR. Echocardiography in the Assessment of Cardiovascular Disease Risk. In: Eduardo M. da Cruz, Dunbar Ivy, James Jaggers, editors, Pediatric and Congenital Cardiology, Cardiac Surgery and Intensive Care. Springer-Verlag London 2013. ISBN:978-1-4471-4618-6.
Kimball TR, Michelfelder EC. Echocardiography: Basic Principles and Imaging. In: Allen HD, Driscoll DJ, Shaddy RE, Feltes TF, editors. Moss & Adams' Heart Disease in Infants, Children and Adolescents: Including the Fetus and Young Adult. 1. Philadelphia, PA: Lippincott Williams & Wilkins; 2012. p. 134-71.
Shah AS, Dolan LM, Gao Z, Kimball TR, Urbina EM. Racial differences in arterial stiffness among adolescents and young adults with type 2 diabetes. Pediatric Diabetes. 2012 Mar;13(2):170-5.
David L. S. Morales, MD Chief of Cardiovascular Surgery, Heart Institute, Cardiothoracic Surgery 513-803-9150 firstname.lastname@example.org
Chief of Cardiovascular Surgery, Heart Institute, Cardiothoracic Surgery
Clark-Helmsworth Chair of Cardiovascular Surgery
UC Division of Surgery
Congenital heart surgery; heterotaxy syndrome; pediatric heart and lung transplantation; mechanical circulatory support