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Meet the team members of the Heart Institute's Heart Failure and Transplant Program at Cincinnati Children's Hospital Medical Center.
Roosevelt Bryant III, MD
Assistant Professor, UC Department of Pediatrics
UC Department of Surgery
BA:Biology, Dillard University, New Orleans, LA, 1990.
MS: Boston University, Boston, BA 1999.
Internship and Residency: General Surgery, University of Kansas, Kansas City, KS, 2004.
Residency: Cardiovascular and Thoracic Surgery, Cleveland Clinic, Cleveland, OH, 2007.
Fellowship: Congenital Heart Surgery, Texas Children's Hospital, Houston, TX, 2009.
Arain N, Braunlin E, St. Louis J, Bryant R 3rd. Delayed Arterial Switch Operation in a Patient with Complete Transposition of the Great Arteries and Glucocorticoid Remediable Aldosteronism. World Journal for Pediatric and Congenital Heart Surgery. 2011 Apr; 2(2):316-17.
Bryant R 3rd, Steiner M, St. Louis JD. Current Use of the EXCOR Pediatric Ventricular Assist Device. J Cardiovasc Transl Res. 2010 Dec;3(6):612-7.
Shepard CW, Kochilas LK, Rosengart RM, Bryant R 3rd, Moller JH, St. Louis JD. Repair of Major Cardiac Defects in Low Birth Weight Infants; Is Delay Warranted? J Thorac Cardiovasc Surg. 2010 Nov;140(5):1104-9.
Arain N, Bryant R 3rd, Ameduri R, Gruenstein D, Braunlin E, Joyce L, St. Louis J. Successful Coil Embolization of a Large Ascending Aortic Pseudoaneurysm Following Explanation of the EXCOR Pediatric Ventricular Assist Device in a Patient with Acute Fulminant Myocarditis. World Journal for Pediatric and Congenital Heart Surgery. 2010;1(2): 259-26.
Owens WR, Bryant R 3rd,Dreyer WJ, Price JF, Morales D. Initial Experience with the Heart Mate II Ventricular Assist System in a Pediatric Institution. Artif Organs. 2010 Jul;34(7):600-3.
Booth JH, Bryant R 3rd, Powers SC, Ge S, McKenzie ED, Heinle JS, Fraser CD, Morales D. Transthoracic Echocardiography Does Not Reliably Predict Involvement of the Aortic Valve in Patients with Discrete Subaortic Shelf. Cardiol Young. 2010 Jun;20(3):284-9.
Zhi D, Bryant R 3rd, Heinle J, Nihill M. Isolated Cleft of the Mitral Valve: Clinical Spectrum and Course. Tex Heart Inst J. 2009;36(6):553-6.
Bryant R 3rd, Morales D. Corkscrew Trachea: A Novel Type of Distal Congenital Tracheal Stenosis. Ann Thorac Surg. 2009 Jun;87(6):1923-5.
Booth JH, Bryant R 3rd, Vaporciyan A, Morales D. Complete Lung Parenchyma Sparing Resection of the Right Main Stem Bronchus and Bronchus Intermedius. J Thorac Cardiovasc Surg. 2009 Mar 6.
Bryant R 3rd, Phalak K, Morales D. Multimodality Therapy for Primary Sternal Osteomyelitis. Pediatr Infect Dis J. 2009 Jan;28(1):73-4.
Chesney Castleberry, MD Heart Failure, Transplant, VAD Physician
Heart Failure, Transplant, VAD Physician
Management and transplantation in patients with palliated congenital heart disease; management of sensitized patients pre- and post- transplant
Transplant immunology; clinical outcomes in heart failure/transplant
MD: University of Texas San Antonio Medical School, San Antonio, TX.
Residency: Pediatrics, Children’s Memorial Hospital, Chicago, IL.
Fellowship: Pediatric cardiology, Children’s Hospital of Wisconsin, Milwaukee, WI; advanced heart failure and transplant, Lucile Packard Children’s Hospital, Palo Alto, CA.
Clifford Chin, MD Medical Director, Pediatric Heart Transplant Services
Medical Director, Pediatric Heart Transplant Services
Professor, UC Department of Pediatrics
Lisa M. Dodd, MSSW, LISW Social Worker, The Heart Institute
John Lynn Jefferies, MD, MPH, FAAP, FACC Director, Advanced Heart Failure and Cardiomyopathy
Director, Advanced Heart Failure and Cardiomyopathy
Associate Professor, UC Department of Pediatrics
Dr. Jefferies, an associate professor of pediatric cardiology and adult cardiovascular diseases, is the director of Advanced Heart Failure / Cardiomyopathy within the Heart Institute at Cincinnati Children's Hospital Medical Center.
He completed his combined pediatric and adult cardiology training at the Baylor College of Medicine in Houston, Texas at the Texas Children's Hospital and the Texas Heart Institute. He has authored or co-authored over 100 peer-reviewed manuscripts and book chapters on cardiomyopathy, cardiovascular genetics, and adults with congenital heart disease.
His current research interests include heritable causes of vascular disease, novel drug therapies for advanced heart failure, novel gene discovery in cardiomyopathy, characterization and management of left ventricular noncompaction (LVNC), and early diagnosis and management of chemotherapy induced cardiotoxicity.
He is on the editorial board of the Texas Heart Institute Journal and is an active member of numerous professional organization including the Heart Failure Society of America, the American College of Cardiology and the American Heart Association.
Jefferies JL, Towbin JA. Dilated cardiomyopathy. Lancet. 2010 Feb;375(9716):752-62. Breinholt JP, Moulik M, Dreyer WJ, Denfield SW, Kim JJ, Jefferies JL, Rossano JW, Gates CM, Clunie SK, Bowles KR, Kearney DL, Bowles NE, Towbin JA. Viral epidemiologic shift in inflammatory heart disease: the increasing involvement of parvovirus B19 in the myocardium of pediatric cardiac transplant patients. J Heart Lung Transplant. 2010 Jul;29(7):739-46. Rossano JW, Morales DL, Zafar F, Denfield SW, Kim JJ, Jefferies JL, Dreyer WJ. Impact of antibodies against human leukocyte antigens on long-term outcome in pediatric heart transplant patients: An analysis of the United Network for Organ Sharing database. J Thorac Cardiovasc Surg. 2010 May 26.
Carlson P, Jefferies JL, Kearney D, Russell H. Refractory dilated cardiomyopathy associated with metastatic neuroblastoma. Pediatr Blood Cancer. 2010 Jun 29.
Shah AM, Jefferies JL, Rossano JW, Decker JA, Cannon BC, Kim JJ. Electrocardiographic abnormalities and arrhythmias are strongly associated with the development of cardiomyopathy in muscular dystrophy. Heart Rhythm. 2010 Jun 18. Moulik M, Breinholt JP, Dreyer WJ, Kearney DL, Price JF, Clunie SK, Moffett BS, Kim JJ, Rossano JW, Jefferies JL, Bowles KR, O'Brian Smith E, Bowles NE, Denfield SW, Towbin JA. Viral Endomyocardial Infection Is an Independent Predictor and Potentially Treatable Risk Factor for Graft Loss and Coronary Vasculopathy in Pediatric Cardiac Transplant Recipients. J Am Coll Cardiol. 2010 56:582-592.Shchelochkov OA, Li FY, Wang J, Zhan H, Towbin JA, Jefferies JL, Wong LJ, Scaglia F. Milder Clinical Course of Type IV 3-Methylglutaconic Aciduria Due to a Novel Mutation in TMEM70. Mol Genet Metab. 2010 101:282-285. Foerster SR, Canter CE, Cinar A, Sleeper LA, Webber SA, Pahl E, Kantor PF, Alvarez JA, Colan SD, Jefferies JL, Lamour JM, Margossian R, Messere JE, Rusconi PG, Shaddy RE, Towbin JA, Wilkinson JD, Lipshultz SE. Ventricular Remodeling and Survival are More Favorable for Myocarditis than for Idiopathic Dilated Cardiomyopathy in Childhood: An Outcomes Study from the Pediatric Cardiomyopathy Registry. Circ Heart Fail. 2010. Jefferies JL, Price JF, Morales DL. Mechanical support in childhood heart failure. Heart Fail Clin. 2010 Oct;6(4):559-73. Jefferies JL, Hoffman TM, Nelson DP. Heart failure treatment in the intensive care unit in children. Heart Fail Clin. 2010 Oct;6(4):531-58.
Angela Lorts, MD Director, Ventricular Assist Device Program
Director, Ventricular Assist Device Program
Heart failure; cardiopulmonary bypass mediated myocardial dysfunction
Lorts A, Burroughs T, Shanley TP. Elucidating the role of reversible protein phosphorylation in sepsis-induced myocardial dysfunction. Shock. 2009 Jul;32(1):49-54. Review.
Lorts A, Schwanekamp JA, Elrod JW, Sargent MA, Molkentin JD. Genetic manipulation of periostin expression in the heart does not affect myocyte content, cell cycle activity, or cardiac repair. Circ Res. 2009 Jan 2;104(1):e1-7.
Oka T, Xu J, Kaiser RA, Melendez J, Hambleton M, Sargent MA, Lorts A, Brunskill EW, Dorn GW 2nd, Conway SJ, Aronow BJ, Robbins J, Molkentin JD. Genetic manipulation of periostin expression reveals a role in cardiac hypertrophy and ventricular remodeling. Circ Res. 2007 Aug 3;101(3):313-21.
McLean KM, Lorts A, Pearl JM. Current treatments for congenital aortic stenosis. Curr Opin Cardiol. 2006 May;21(3):200-4. Review.
David L. S. Morales, MD Chief of Cardiovascular Surgery, Heart Institute, Cardiothoracic Surgery
Chief of Cardiovascular Surgery, Heart Institute, Cardiothoracic Surgery
Clark-Helmsworth Chair of Cardiovascular Surgery
UC Division of Surgery
Congenital heart surgery; heterotaxy syndrome; pediatric heart and lung transplantation; mechanical circulatory support
Clinical and translational research related to mechanical circulatory support and tissue engineering
MD: Yale University School of Medicine, New Haven, CT.
Residency: General and cardiothoracic surgery, New York-Presbyterian Medical Center, Columbia University, New York, NY.Fellowships: Congenital heart surgery, Texas Children’s Hospital, Baylor University, Waco, TX.
Board certifications: Surgery, thoracic surgery, congenital heart surgery.
Thomas D. Ryan, MD, PhD Heart Failure, Transplant, VAD Physician
Cardiomyopathy; heart failure; heart transplantation; mechanical circulatory support
Development of cardiomyopathy in at risk populations, including Duchenne muscular dystrophy and other genetic cardiomyopathies, and anthracycline exposure.
Thomas D Ryan, MD, PhD, was born and raised in Wichita, KS and graduated magna cum laude from Wichita State University in 1996 with a BS in Biological Sciences.
In 1997 he began training in the MD/PhD program at the University of Alabama at Birmingham, and studied the molecular, cellular, and whole organ aspects of cardiac remodeling in a rat model of volume overload. His general pediatrics residency training took place at Cincinnati Children’s Hospital Medical Center from 2006-2009, as did his Pediatric Cardiology fellowship training from 2009-2012 and advanced fellowship in Pediatric Heart Failure/Transplant from 2012-2013. His clinical and research interests focus on heart failure, cardiomyopathy, cardiac transplantation, and mechanical circulatory support.
BS: Wichita State University, Wichita, KS, 1996.
PhD: University of Alabama at Birmingham, Birmingham, AL, 2004.
MD: University of Alabama at Birmingham, Birmingham, AL, 2005.
Residency: Pediatrics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2006-2009.
Fellowship: Pediatric Cardiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2009-2012.
Advanced Fellowship: Pediatric Heart Failure/Transplant, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2012-2013.
Certification: American Board of Pediatrics, 2010; American Board of Pediatrics, Sub-board of Pediatric Cardiology, 2012.
Ryan TD, Gupta D, Gupta A, Goldenberg P, Taylor MD, Lorts A, Jefferies JL. Cardiomyopathy in a Patient with Russell-Silver Syndrome. Cardiovasc Path. 2013 Sep 24. Epub ahead of print.
Ryan TD, Taylor MD, Wojciech M, Cripe LH, Pratt J, King EC, Lao K, Grenier MA, Jefferies JL, Benson DW, Hor KH. Abnormal circumferential strain is present in young Duchenne muscular dystrophy patients. Pediatric Cardiol. 2013 Jun;34(5):1159-65.
Ryan TD, Ware SM, Lucky AW, Towbin JA, Jefferies JL, Hinton RB. Left ventricular noncompaction cardiomyopathy and aortopathy in a patient with recessive dystrophic epidermolysis bullosa. Circ Heart Fail. 2012 Sep 1;5(5):e81-2.
Ryan TD, Rothstein EC, Aban I, Tallaj JA, Husain A, Lucchesi PA, Dell'Italia LJ. Left ventricular eccentric remodeling and matrix loss are mediated by bradykinin and precede cardiomyocyte elongation in rats with volume overload. J Am Coll Cardiol. 2007 Feb 20;49(7):811-21.
Ryan TD, Dimmitt RA, Tubbs RS, Roberts OA, Choi H, Loukas M, Blount JP. Contribution of surgical evacuation of a large subgaleal hematoma to the resolution of severe conjugated hyperbilirubinemia in a neonate. Case report. J Neurosurg. 2007 Feb;106(2 Suppl):131-3.
Shelly L. Stark, MSN, APRN, CPNP-AC Acute Care Pediatric Nurse Practitioner, Heart Failure/Cardiomyopathy/Transplant, Heart Institute
Acute Care Pediatric Nurse Practitioner, Heart Failure/Cardiomyopathy/Transplant, Heart Institute
Pediatric cardiology; cardiomyopathy; heart failure; heart transplant.
Pediatric cardiac transplant; heart failure
RN Co-Op Program: Cincinnati Children's Hospital Medical Center (Transitional Care Center, Cardiac Intensive Care Unit), Cincinnati, OH, 2008-2009.
BSN: Nursing, University of Cincinnati, Cincinnati, OH, 2009.
RN: Cardiac Intensive Care Unit, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2009-2013
MSN: Acute Care Pediatric Nurse Practitioner, University of Cincinnati, Cincinnati, OH, 2013.
CPNP-AC: Pediatric Nursing Certification Board, 2013.
APRN: Heart Failure/Cardiomyopathy/Transplant Services, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2013.
BreAnn Taylor, PharmD, BCPS Clinical Pharmacy Specialist, Outpatient Cardiology, Division of Pharmacy
Jeffrey A. Towbin, MD, FAAP, FACC, FAHA Executive Co-Director, Heart Institute; Chief, Pediatric Cardiology
Executive Co-Director, Heart Institute; Chief, Pediatric Cardiology
Director, Heart Institute Diagnostic Laboratory
BS: Biology, University of Cincinnati, 1974.MS: Cell Biology, University of Cincinnati, 1977.MD: University of Cincinnati, 1982.
Residency: Pediatrics, Cincinnati Children's Hospital Medical Center, 1985.
Fellowship: Pediatric Cardiology, Baylor College of Medicine, Texas Children's Hospital, 1989.
McBride KL, Zender GA, Fitzgerald-Butt SM, Seagraves NJ, Fernbach SD, Zapata G, Lewin M, Towbin JA, Belmont JW. Association of common variants in ERBB4 with congenital left ventricular outflow tract obstruction defects. Birth Defects Res A Clin Mol Teratol. 2011 Mar;91(3):162-8.
Fakhro KA, Choi M, Ware SM, Belmont JW, Towbin JA, Lifton RP, Khokha MK, Brueckner M. Rare copy number variations in congenital heart disease patients identify unique genes in left-right patterning. Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):2915-20.
Goldenberg I, Horr S, Moss AJ, Lopes CM, Barsheshet A, McNitt S, Zareba W, Andrews ML, Robinson JL, Locati EH, Ackerman MJ, Benhorin J, Kaufman ES, Napolitano C, Platonov PG, Priori SG, Qi M, Schwartz PJ, Shimizu W, Towbin JA, Vincent GM, Wilde AA, Zhang L. Risk for life-threatening cardiac events in patients with genotype-confirmed long-QT syndrome and normal-range corrected QT intervals. J Am Coll Cardiol. 2010 Dec 28;57(1):51-9.
Towbin JA, Ware SM, Jefferies JL. Heart transplants in pediatric patients: viral infection as a loss predictor. Future Cardiol. 2010 Nov;6(6):735-41.
Foerster SR, Canter CE, Cinar A, Sleeper LA, Webber SA, Pahl E, Kantor PF, Alvarez JA, Colan SD, Jefferies JL, Lamour JM, Margossian R, Messere JE, Rusconi PG, Shaddy RE, Towbin JA, Wilkinson JD, Lipshultz SE. Ventricular remodeling and survival are more favorable for myocarditis than for idiopathic dilated cardiomyopathy in childhood: an outcomes study from the Pediatric Cardiomyopathy Registry. Circ Heart Fail. 2010 Nov 1;3(6):689-97.
Purevjav E, Varela J, Morgado M, Kearney DL, Li H, Taylor MD, Arimura T, Moncman CL, McKenna W, Murphy RT, Labeit S, Vatta M, Bowles NE, Kimura A, Boriek AM, Towbin JA. Nebulette mutations are associated with dilated cardiomyopathy and endocardial fibroelastosis. J Am Coll Cardiol. 2010 Oct 26;56(18):1493-502. Towbin JA. Left ventricular noncompaction: a new form of heart failure. Heart Fail Clin. 2010 Oct;6(4):453-69 Towbin JA. Preface: Heart failure in children. Heart Fail Clin. 2010 Oct;6(4):xvii-iii.
Wilkinson JD, Landy DC, Colan SD, Towbin JA, Sleeper LA, Orav EJ, Cox GF, Canter CE, Hsu DT, Webber SA, Lipshultz SE. The pediatric cardiomyopathy registry and heart failure: key results from the first 15 years. Heart Fail Clin. 2010 Oct;6(4):401-13 Towbin JA. Hypertrophic cardiomyopathy. Pacing Clin Electrophysiol. 2009 Jul;32 Suppl 2:S23-31.
Ivan Wilmot, MD Heart Failure, Transplant, VAD Physician
Heart failure, transplantation, and mechanical circulatory support.
Care of children with advanced heart failure requiring mechanical circulatory support bridge to transplant; quality of life in children with heart failure, transplant and mechanical circulatory support (MCS); advanced strain imaging in evaluation of ventricular function in pediatric heart transplant patients.
Ivan Wilmot, MD, graduated summa cum laude from Louisiana State University with a Bachelor's of Science in zoology.
In 1998 he began medical school at Emory University. His general pediatrics residency training took place at the Emory Affiliated Hospitals from 2002 to 2006. He completed his pediatric cardiology fellowship training from 2006 to 2009, and advanced fellowship in heart failure and transplant from 2009 to 2010.
His clinical and research interests focus on heart failure, cardiac transplantation and mechanical circulatory support (MCS).
BS: Louisiana State University, 1998.
MD: Emory University School of Medicine, Atlanta, GA, 2002.
Residency: Emory Affiliated Hospitals, Atlanta, GA, 2005; Chief Resident: Emory Affiliated Hospitals, Atlanta, GA, 2006.
Fellowship: Baylor College of Medicine, Texas Children’s Hospital, Houston, TX, 2009.
Advanced Fellowship: Heart Failure and Transplant, Baylor College of Medicine, Texas Children’s Hospital, Houston, TX, 2010.
Certification: American Board of Pediatrics; American Board of Pediatrics Sub-board of Pediatric Cardiology.
Stapleton GE, Wilmot I, Suh EJ. Cardiac catheterisation of patients with common arterial trunk and transposition of the great arteries. Cardiol Young. 2012 Dec:22(6), 687–690.
Dadlani GH, Braley K, Perez-Colon E, Stapleton G, Crawford M, Turpin D, Wilmot I, Freire G, Decker J, Martinez R. Long-term management of patients with hypoplastic left heart syndrome: the diagnostic approach at All Children's Hospital. Cardiol Young. 2011 Dec:21 Suppl 2, 80–87.
Asante-Korang A, Jacobs JP, Ringewald J, Carapellucci J, Rosenberg K, McKenna D, McCormack J, Wilmot I, Gjeldum A, Lopez-Cepero M, Sleasman J. Management of children undergoing cardiac transplantation with high Panel Reactive Antibodies. Cardiol Young. 2011 Dec:21 Suppl 2, 124–132.
Wilmot I, Morales DL, Price JF, Rossano JW, Kim JJ, Decker JA, McGarry MC, Denfield SW, Dreyer, WJ, Towbin JA, Jeffries JL. Effectiveness of mechanical circulatory support in children with acute fulminant and persistent myocarditis. J Card Fail. 2011 June:17(6), 487–494.
Perez-Colon E, Dadlani GH, Wilmot I, Miller M. Mesalamine-induced myocarditis and coronary vasculitis in a pediatric ulcerative colitis patient: a case report. Case Rep Peditr. 2011; 524364.
Sharef S, Coleman R, Rivenes S, Wilmot I, Altman C, Madden-Fuentes R, Salazar J. Stentless xenograft implantation in aortic position in a 7-year-old girl. Tex Heart Inst J. 2010; 37(3), 347–349.
Wilmot I, Kanter KR, Vincent RN, Berg AM, Mahle WT. OKT3 treatment in refractory pediatric heart transplant rejection. J Heart Lung Transplant. 2005 Nov;24(11):1793-7.
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