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The Hemophilia Center is home to specialists with a wide variety of backgrounds and areas of focus. As a team, this diversity makes us better prepared to care for your child’s unique needs. Learn more about our faculty and staff.
Ralph A. Gruppo, MD Director, Comprehensive Hemophilia and Thrombosis Center 513-636-8617 firstname.lastname@example.org
Director, Comprehensive Hemophilia and Thrombosis Center
Director, Research Coagulation Laboratory
Director, Special Hemostasis & Thrombosis Laboratory
Professor, UC Department of Pediatrics
Coagulation; hemophilia; thrombosis
MD: Johns Hopkins Medical School, Baltimore, MD, 1967.
Residency: Children's Hospital Medical Center, Cincinnati, Ohio; Johns Hopkins School of Medicine, Baltimore, MD, 1970.
Fellowship: Children's Hospital Medical Center, Cincinnati, OH, 1974.
Certification: Pediatrics, 1975; Pediatric Hematology/Oncology, 1976.
Gruppo RA. Treatment of hemophilia in developing countries: a journey of a thousand miles. Pediatr Blood Cancer. 2010 Mar;54(3):348-9. No abstract available
Gelfand MJ, Gruppo RA, Nasser MP. Ventilation-perfusion scintigraphy in children and adolescents is associated with a low rate of indeterminate studies. Clin Nucl Med. 2008 Sep;33(9):606-9.
Wu SW, Graham B, Gelfand MJ, Gruppo RE, Dinopolous A, Gilbert DL. Clinical and positron emission tomography findings of chorea associated with primary antiphospholipid antibody syndrome. Mov Disord. 2007 Sep 15;22(12):1813-5.
Balasa VV, Gruppo RA, Glueck CJ, Wang P, Roy DR, Wall EJ, Mehlman CT, Crawford AH. Legg-Calve-Perthes disease and thrombophilia. J Bone Joint Surg Am. 2004 Dec;86-A(12):2642-7.
Gruppo RA, Brown D, Wilkes MM, Navickis RJ. Increased breakthrough bleeding during prophylaxis with B-domain deleted factor VIII -- a robust meta-analytic finding. Haemophilia. 2004 Sep;10(5):449-51.
Morrison JA, Gruppo R, Glueck CJ, Stroop D, Fontaine RN, Wang P, Smith KL. Population-specific alleles: the polymorphism (K121Q) of the human glycoprotein PC-1 gene is strongly associated with race but not with insulin resistance in black and white children. Metabolism. 2004 Apr;53(4):465-8.
Gruppo RA, Brown D, Wilkes MM, Navickis RJ. Comparative effectiveness of full-length and B-domain deleted factor VIII for prophylaxis -- a meta-analysis. Haemophilia. 2003 May;9(3):251-60. Review.
Balasa VV, Kalinyak KA, Bean JA, Stroop D, Gruppo RA. Hyperhomocysteinemia is associated with low plasma pyridoxine levels in children with sickle cell disease. J Pediatr Hematol Oncol. 2002 Jun-Jul;24(5):374-9.
McNamara JL, Lombardi JP, Ferguson R, Manning PB, Gruppo RA. Alternative methods for anticoagulation monitoring in pediatric patients with applicability to a patient with severe hemophilia A and circulating inhibitor. J Extra Corpor Technol. 2001 Dec;33(4):239-42.
Gruppo R, Degrauw A, Fogelson H, Glauser T, Balasa V, Gartside P. Protein C deficiency related to valproic acid therapy: a possible association with childhood stroke. J Pediatr. 2000 Nov;137(5):714-8.
Eric Mullins, MD Research Director, Hemophilia Treatment Center 513-636-4266 email@example.com
Research Director, Hemophilia Treatment Center
Assistant Professor, UC Department of Pediatrics
Care of children and adolescents with bleeding and thrombotic disorders; hemophilia; von Willebrand’s disease; Young Women’s Bleeding Disorder Clinic; disordered menstrual bleeding; Hemophilia Treatment Center
MD: University of Missouri, Columbia, MO.
Residency: Vanderbilt University Medical Center, Nashville, TN, 2001-2004.
Fellowship: Pediatric Hematology / Oncology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2004-2007; Pediatric Hemostasis Fellowship, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2007-2008; Chief Fellow, Pediatric Hematology / Oncology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2007-2008.
Board Certifications: Pediatrics, 2004-Present; Pediatric Hematology/Oncology, 2009-Present.
Raghu H, Cruz C, Rewerts CL, Frederick MD, Thornton S, Mullins ES, Schoenecker JG, Degen JL, Flick MJ. Transglutaminase factor XIII promotes arthritis through mechanisms linked to inflammation and bone erosion. Blood. 2014 Oct 21.
Huang Y, Shaw MA, Mullins ES, Kirley TL, Ayres N. Synthesis and anticoagulant activity of polyureas containing sulfated carbohydrates. Biomacromolecules. 2014 Oct 20.
Turpin B, Miller W, Rosenfeldt L, Kombrinck K, Flick MJ, Steinbrecher KA, Harmel-Laws E, Mullins ES, Shaw M, Witte DP, Revenko A, Monia B, Palumbo JS. Thrombin drives tumorigenesis in colitis-associated colon cancer. Cancer Res. 2014 Jun 1;74(11):3020-30.
Davalos D, Baeten KM, Whitney MA, Mullins ES, Friedman B, Olson ES, Ryu JK, Smirnoff DS, Petersen MA, Bedard C, Degen JL, Tsien RY, Akassoglou K. Early detection of thrombin activity in neuroinflammatory disease. Ann Neurol. 2014 Feb;75(2):303-8.
Horowitz NA, Blevins EA, Miller WM, Perry AR, Talmage KT, Mullins
ES, Flick MJ, Queiroz KCS, Speck CA, Conway EM, Monia BP, Weiler H,
Degen JL, Palumbo J. Thrombomodulin is a determinant of metastasis
through a mechanism linked to the thrombin binding domain but not the
lectin-like domain. Blood. 2011;118:2889-95.
Flick MJ, Chauhan AK, Frederick M, Talmage KE, Kombrinck KW, Miller W,
Mullins ES, Palumbo JS, Zheng X, Esmon NL, Esmon CT, Thornton S, Becker
A, Pelc LA, Di Cera E, Wagner DD, Degen JL. The development of
inflammatory joint disease is attenuated in mice expressing the
anticoagulant prothrombin mutant W215A/E217A. Blood. 2011;117:6326-37.
Mullins ES, Kombrinck KW, Talmage KE, Shaw MA, Witte DP, Ullman JM, Degen SJ, Sun W, Flick MJ, Degen JL. Genetic elimination of prothrombin in adult mice is not compatible with survival and results in spontaneous hemorrhagic events in both heart and brain. Blood. 2009;113:676-704.
Joseph S. Palumbo, MD Director, Comprehensive Thrombophilia Center 513-636-4266 firstname.lastname@example.org
Director, Comprehensive Thrombophilia Center
Associate Professor, UC Department of Pediatrics
Interactions between the hemostatic system and innate immunity effecting tumor progression; Langerhans' cell histiocytosis
MD: Pennsylvania State University College of Medicine, Hershey, PA, 1993.
Residency: Childrens Hospital Medical Center, Cincinnati, OH, 1997.
Fellowship: Childrens Hospital Medical Center, Cincinnati, OH, 2000.
Subspecialty: Pediatric Hematology / Oncology.
Horowitz NA, Blevins EA, Miller WM, Perry AR, Talmage KE, Mullins ES, Flick MJ, Queiroz KC, Shi K, Spek CA, Conway EM, Monia BP, Weiler H, Degen JL, Palumbo JS. Thrombomodulin is a determinant of metastasis through a mechanism linked to the thrombin binding domain but not the lectin-like domain. Blood. 2011 Jul 25.
Flick MJ, Chauhan AK, Frederick M, Talmage KE, Kombrinck KW, Miller W, Mullins ES, Palumbo JS, Zheng X, Esmon NL, Esmon CT, Thornton S, Becker A, Pelc LA, Di Cera E, Wagner DD, Degen JL. The development of inflammatory joint disease is attenuated in mice expressing the anticoagulant prothrombin mutant W215A/E217A. Blood. 2011 Jun 9;117(23):6326-37.
Akunuru S, Palumbo J, Zhai QJ, Zheng Y. Rac1 targeting suppresses human non-small cell lung adenocarcinoma cancer stem cell activity. PLoS One. 2011 Feb 9;6(2):e16951.
Palumbo JS, Degen JL. Mechanisms coupling the hemostatic system to colitis-associated cancer. Thromb Res. 2010 Apr;125 Suppl 2:S39-43. Review.
Steinbrecher KA, Horowitz NA, Blevins EA, Barney KA, Shaw MA, Harmel-Laws E, Finkelman FD, Flick MJ, Pinkerton MD, Talmage KE, Kombrinck KW, Witte DP, Palumbo JS. Colitis-associated cancer is dependent on the interplay between the hemostatic and inflammatory systems and supported by integrin alpha(M)beta(2) engagement of fibrinogen. Cancer Res. 2010 Apr 1;70(7):2634-43.
Palumbo JS. Mechanisms linking tumor cell-associated procoagulant function to tumor dissemination. Semin Thromb Hemost. 2008 Mar;34(2):154-60. Review.
Palumbo JS, Barney KA, Blevins EA, Shaw MA, Mishra A, Flick MJ, Kombrinck KW, Talmage KE, Souri M, Ichinose A, Degen JL. Factor XIII transglutaminase supports hematogenous tumor cell metastasis through a mechanism dependent on natural killer cell function. J Thromb Haemost. 2008 May;6(5):812-9.
Palumbo JS, Degen JL. Mechanisms linking tumor cell-associated procoagulant function to tumor metastasis. Thromb Res. 2007;120 Suppl 2:S22-8.
Flick MJ, LaJeunesse CM, Talmage KE, Witte DP, Palumbo JS, Pinkerton MD, Thornton S, Degen JL. Fibrin(ogen) exacerbates inflammatory joint disease through a mechanism linked to the integrin alphaMbeta2 binding motif. J Clin Invest. 2007 Nov;117(11):3224-35.
Palumbo JS, Talmage KE, Massari JV, La Jeunesse CM, Flick MJ, Kombrinck KW, Hu Z, Barney KA, Degen JL. Tumor cell-associated tissue factor and circulating hemostatic factors cooperate to increase metastatic potential through natural killer cell-dependent and-independent mechanisms. Blood. 2007 Jul 1;110(1):133-41.
Cristina Tarango, MD Medical Director, Hemophilia Treatment Center 513-636-4266 email@example.com
Medical Director, Hemophilia Treatment Center
Clinical Director, Hematology Program
Pediatric bleeding disorders and thrombosis; quality improvement; medical education
MD: Stanford University School of Medicine, Stanford, CA, 2003.
Residency: Yale-New Haven Hospital, New Haven, CT, 2006.
Fellowship: University of Texas Southwestern Medical Center Dallas, Dallas, TX, 2009.
Certification: Pediatrics, 2006; Pediatric Hematology Oncology, 2011.
Kukreja KU, Lungren MP, Patel MN, Johnson ND, Racadio JM, Dandoy C, Tarango C. Endovascular venous thrombolysis in children younger than 24 months. J Vasc Interv Radiol. 2014 Aug;25(8):1158-64.
Tarango C, Ware RE. Gamma prime fibrinogen and childhood obesity: ready for prime time? J Pediatr. 2013 Aug;163(2):315-6. Editorial.
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