Hereditary Liver Diseases Genetic Testing

  • Meet the Team

    The Heritable Liver Disease Genetic Testing Service is a collaboration between the Molecular Genetics Laboratory and Jorge Bezerra, MD, a pediatric gastroenterologist and developer of the JaundiceChip Resequencing Array, at Cincinnati Children's Hospital Medical Center. This partnership allows for optimum care of your patients.

    We are staffed by a team of experts who provide guidance in:

    • Test selection
    • Clinical interpretation
    • Medical management and follow-up testing
    • Recommendations for genetic counseling
    • Coordination of studies for at-risk family members
    • Billing and reimbursement

    Clinical interpretations are written in conjunction with our nationally recognized pediatric gastroenterologist, board-certified molecular and medical geneticists and genetic counselors. Each report is customized for your patient and includes a detailed interpretation of the genetic findings, the clinical significance of the results and the specific recommendations for clinical management and additional testing, if warranted. These specialists are also available to you for pretest or additional post-test consultation.

  • Show All

    Clinical Experts

    Jorge A. Bezerra, MD

    Professor, UC Department of Pediatrics

    Phone: 513-636-3008

    Fax: 513-636-5581

    Email: jorge.bezerra@cchmc.org

    Show All

    Specialties

    Biography

    Jorge A. Bezerra, MD, joined the Cincinnati Children's Hospital Medical Center Division of Gastroenterology, Hepatology and Nutrition in 1990, when he began his fellowship training in pediatric gastroenterology and nutrition and graduated in 1993.

    From 1992-1994, Dr. Bezerra was a research scholar in the Division of Basic Sciences. He was appointed to the division in 1994 as an assistant professor of pediatrics.

    Dr. Bezerra completed his residency in pediatrics at the University of Arizona in Tucson, Arizona.

    Dr. Bezerra has an active research career with his primary interests in molecular control of liver regeneration, biliary atresia, and genetic basis of intrahepatic cholestasis.

    In addition to his research work, Dr. Bezerra is an active clinician for the outpatient GI clinical service and the inpatient liver service.

    Education and Training

    MD: Federal University Rio Grande Norte, Natal, Brazil, 1984

    Residency: University of Arizona, Tuscon, AZ, 1989

    Fellowship: Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH, 1994

    Certification: Pediatrics, Pediatric Gastroenterology, Hepatology and Nutrition

    Publications

    View PubMed Publications

    Alexander G. Miethke, MD

    Assistant Professor, UC Department of Pediatrics

    Phone: 513-636-8948

    Email: alexander.miethke@cchmc.org

    Show All

    Specialties

    Clinical Interests

    Pediatric liver disease including biliary atresia, inherited liver diseases, autoimmune hepatitis, and primary sclerosing cholangitis; gastrointestinal problems in children with bone marrow failure syndromes

    Research Interests

    Immune mediated liver injury, specifically the role of regulatory T cells in biliary atresia and primary sclerosing cholangitis; genetic basis for intrahepatic cholestasis in children; acute liver failure in infants with mitochondrial disorders

    Biography

    Alexander G. Miethke , MD, joined the Division of Gastroenterology, Hepatology and Nutrition as a fellow in 2005, after completing his Pediatric Residency Training at Cincinnati Children's Hospital Medical Center. Following the completion of his fellowship, he pursued an additional year of training in pediatric transplant hepatology under the mentorship of Dr. William Balistreri and the physicians and surgeons of the Pediatric Liver Care Center.

    In 2009, Dr. Miethke was appointed assistant professor of pediatrics in the Division of Gastroenterology, Hepatology and Nutrition and the Pediatric Liver Care Center. His basic science research interests include the role of regulatory T cells in biliary atresia and other immune mediated liver diseases and the genetic basis of chronic cholestasis syndromes.

    Education and Training

    MD: Humboldt-University, Berlin, Germany, 2000.

    Residency: Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2002-2004.

    Fellowship: Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2005-2007.

    Advanced Fellowship: Pediatric Transplant Hepatology, University of Cincinnati and Cincinnati Children's Hospital Medical Center, 2009.

    Certification: Pediatrics, 2005; Pediatric Gastroenterology 2009; Pediatric Transplant Hepatology, 2010.

    Publications

    View PubMed Publications

    Grants

    Regulatory T cells and the pathogenesis of biliary atresia. Principal Investigator. American Liver Foundation. Jul 2009 - Jun 2012.

    Clinical center for cholestatic liver disease in children. Co-Investigator. National Institutes of Health. Jul 2009 - Jul 2014. #RFA-DK-08-005.

    A photo of Kejian Zhang.

    Kejian Zhang, MD, MBA
    Director, Molecular Genetics Laboratory

    513-636-0121

    kejian.zhang@cchmc.org

    Kejian Zhang, MD, MBA

    Director, Molecular Genetics Laboratory

    Associate Professor, UC Department of Pediatrics

    Phone: 513-636-0121

    Fax: 513-636-2261

    Email: kejian.zhang@cchmc.org

    Show All

    Specialties

    Clinical Interests

    Molecular genetics diagnosis of inherited immunodeficiency disorders and other genetic conditions

    Research Interests

    Molecular defects and molecular diagnosis of primary immunodeficiency diseases; Genetic aspects of predictive personalized medicine (pharmacogenetics)

    Education and Training

    MD: Tianjin Medical University, Tianjin, China, 1993

    MBA: University of Cincinnati, College of Business Administration, 2001

    Residency: Gong'an Hospital, Tianjin, China, 1993-1995

    Fellowship: Clinical Molecular Genetics Fellow, Division of Human Genetics, Cincinnati Children's Hospital, 2002-2004

    Publications

    View PubMed Publications

    Grants

    Macrophage Activation Syndrome Biomarkers in Systemic Juvenile Idiopathic Arthritis. Co-investigator. National Institute of Arthritis, Musculoskeletal and Skin Diseases. Aug 2007 - Dec 2012.

    MUNC13-4 gene Polymorphisms in Macrophage Activation syndrome and Systemic Juvenile Idiopathic Arthritis. Co-Investigator. National Institute of Health. Sept 2011 - Aug 2016.