• Research: Understanding HLH

    Currently, Cincinnati Children’s is conducting many research studies that could change the face of diagnosis and care for HLH. We have six physician scientists who are focused solely on basic and translational research in HLH. Some of our ongoing innovative work includes: 

    • Development of an HLH gene chip
    • Novel protocol for initial treatment: HIT-HLH
    • Preclinical studies of gene therapy in PRF1 deficiency
    • Preclinical studies of small molecule targeted therapy 

    While we already have strong collaborations with the National Institutes of Health (NIH) and other HLH centers in China, Japan, Vietnam, Canada and Sweden, we plan to further extend our scientific collaborations across Europe, Central and South America, and Asia. 

    We are also working to increase research funding for HLH through industry grants, additional NIH funding and philanthropic support.

    Published Research

    > Read some of our HLH research articles from PubMed.gov

  • Researchers in the Spotlight

    Dr. Lisa Filipovich.

    HLH Meets its Match: Dr. Lisa Filipovich has spent her career unraveling the mysteries of the childhood immune disorder hemophagocytic lymphohistiocytosis (HLH). Her focus now is to improve treatment and ultimately prevent the disease.


    Dr. Michael Jordan.

    Calming a Storm in the Immune System: Dr. Michael Jordan developed the perforin-deficient animal model that is helping advance the study of better treatments for HLH. He is now leading a multicenter clinical trial testing a new approach for treating HLH.

  • 700 Miles to Hope Bike Ride

    The 2014 Mathew and Andrew Akin Foundation's 700 Miles to Hope Bike Ride presented a check for $350,000 to HLH Center of Excellence. Learn more.
  • Referral Information

    Contact us to learn more about the HLH Center of Excellence, make an appointment or refer a patient:
    Phone: 877-920-3590
    Email: HLH@cchmc.org