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The Schubert-Martin Inflammatory Bowel Disease Center is home to specialists with a wide variety of backgrounds and areas of focus. As a team, this diversity makes us better prepared to care for your child’s unique needs. Learn more about our faculty and staff.
Lee A. Denson, MD Medical Director, Inflammatory Bowel Disease Center
Medical Director, Inflammatory Bowel Disease Center
Professor, UC Department of Pediatrics
Inflammatory bowel disease; growth failure; celiac disease
Visit the Denson Lab.
The primary focus of Dr. Lee A. Denson's laboratory is to determine the molecular basis for alterations in growth hormone signaling in inflammatory bowel diseases (IBD).
Normal growth and development are dependent upon the ability of growth hormone to regulate IGF-1 expression. Evidence from studies in children with IBD and mouse models of colitis indicates that inflammatory cytokines which are up regulated in this setting may cause an acquired GH resistance. Consequences may include growth failure, altered body composition and impaired mucosal healing.
We are using complementary experimental and patient-based approaches to investigate regulation of growth hormone signaling in mouse models of colitis and in children with Crohn's disease. These include down regulation of the growth hormone receptor and up regulation of a family of post-receptor inhibitory proteins, the Suppressors of Cytokine Signaling (SOCS). These studies should lead to the development of more effective therapies for children with IBD and other chronic inflammatory conditions.
Herzer M, Denson LA, Baldassano RN, Hommel KA. Family functioning and health-related quality of life in adolescents with pediatric inflammatory bowel disease. Eur J Gastroenterol Hepatol. 2011 Jan;23(1):95-100.
Gray WN, Denson LA, Baldassano RN, Hommel KA. Disease activity, behavioral dysfunction, and health-related quality of life in adolescents with inflammatory bowel disease. Inflamm Bowel Dis. 2010 Nov 4.
Lawal TA, Frischer JS, Falcone RA, Chatoorgoon K, Denson LA, Levitt MA. The transanal approach with laparoscopy or laparotomy for the treatment of rectal strictures in Crohn's disease. J Laparoendosc Adv Surg Tech A. 2010 Nov;20(9):791-5.
Denson LA, Kim MO, Bezold R, Carey R, Osuntokun B, Nylund C, Willson T, Bonkowski E, Li D, Ballard E, Collins M, Moyer MS, Klein DJ. A randomized controlled trial of growth hormone in active pediatric Crohn disease. J Pediatr Gastroenterol Nutr. 2010 Aug;51(2):130-9.
Nylund CM, Denson LA, Noel JM. Bacterial enteritis as a risk factor for childhood intussusception: a retrospective cohort study. J Pediatr. 2010 May;156(5):761-5.
Ingerski LM, Baldassano RN, Denson LA, Hommel KA. Barriers to oral medication adherence for adolescents with inflammatory bowel disease. J Pediatr Psychol. 2010 Jul;35(6):683-91.
Tomer G, Wetzler G, Keddache M, Denson LA. Polymorphisms in the IBD5 locus are associated with Crohn disease in pediatric Ashkenazi Jewish patients. J Pediatr Gastroenterol Nutr. 2009 May;48(5):531-7.
Uchida K, Nakata K, Suzuki T, Luisetti M, Watanabe M, Koch DE, Stevens CA, Beck DC, Denson LA, Carey BC, Keicho N, Krischer JP, Yamada Y, Trapnell BC. Granulocyte/macrophage-colony-stimulating factor autoantibodies and myeloid cell immune functions in healthy subjects. Blood. 2009 Mar 12;113(11):2547-56.
Han X, Uchida K, Jurickova I, Koch D, Willson T, Samson C, Bonkowski E, Trauernicht A, Kim MO, Tomer G, Dubinsky M, Plevy S, Kugathsan S, Trapnell BC, Denson LA. Granulocyte-macrophage colony-stimulating factor autoantibodies in murine ileitis and progressive ileal Crohn's disease. Gastroenterology. 2009 Apr;136(4):1261-71, e1-3.
Denson LA. Growth hormone therapy in children and adolescents: pharmacokinetic/pharmacodynamic considerations and emerging indications. Expert Opin Drug Metab Toxicol. 2008 Dec;4(12):1569-80. Review.
Dana (Chelly) Dykes, MD
Assistant Professor, UC Department of Pediatrics
Pediatric inflammatory bowel disease
BS: Neuroscience and French, Vanderbilt University, Nashville, TN, 2002.
MD: University of Alabama School of Medicine, Birmingham, AL, 2006.
MS: Clinical and Translational Research, University of Cincinnati, Cincinnati, OH, 2012.
Residency: Pediatrics, Children’s Hospital at UAB, Birmingham, AL, 2009.
Fellowship: Pediatric Gastroenterology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2012.
Park KT, Crandall WV, Fridge J, Leibowitz IH, Tsou M, Dykes DM, Hoffenberg EJ, Kappelman MD, Colletti RB. Implementable Strategies and Exploratory Considerations to Reduce Costs Associated with Anti-TNF Therapy in Inflammatory Bowel Disease Inflammatory Bowel Diseases. Inflamm Bowel Dis. 2014 May;20(5):946-51.
Dykes DM, Saeed SA. Imaging for inflammatory bowel disease: the new "sounding board". J Pediatr. 2013 Sep;163(3):625-6.
Dykes DM, Towbin AJ, Bonkowski E, Chalk C, Bezold R, Lake K, Kim MO, Heubi JE, Trapnell BC, Podberesky DJ, Denson LA. Increased Prevalence of Luminal Narrowing and Stricturing Identified by Enterography in Pediatric Crohn Disease Patients with Elevated Granulocyte-Macrophage Colony Stimulating Factor Auto-antibodies. Inflamm Bowel Dis. 2013 Sep;19(10):2146-54.
Phillip Minar, MD
Pediatric gastroenterology; biomarkers of treatment response and disease severity in inflammatory bowel disease.
BA: Duquesne University, Pittsburgh, PA.
MD: Medical College of Wisconsin, Milwaukee, WI.
Residency: Pediatrics, Medical College of Wisconsin/Children's Hospital of Wisconsin, Milwaukee, WI.
Fellowship: Pediatric Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
Certification: General Pediatrics; Pediatric Gastroenterology.
Michael J. Rosen, MD, MSCI Attending Physician, Division of Gastroenterology, Hepatology and Nutrition
Attending Physician, Division of Gastroenterology, Hepatology and Nutrition
Physician, Schubert-Martin Inflammatory Bowel Disease Center
Inflammatory bowel disease
Inflammatory bowel disease; intestinal mucosal immunology
Michael J. Rosen, MD, MSCI, focuses his career on the clinical care of children with inflammatory bowel disease (IBD), and to research aimed at better understanding the causes of chronic inflammation in childhood IBD. The primary focus of Dr. Rosen's laboratory is on the contribution of Type 2 (Th2) inflammation to pediatric colitis. Studies from Dr. Rosen’s lab have demonstrated increased mucosal activation of STAT6, a key Th2 cellular signaling protein, in children with ulcerative colitis and shown a role for STAT6 in perpetuating inflammation in a mouse model similar to ulcerative colitis.
Dr. Rosen is currently funded by the National Institutes of Health (NIH) to study the expression of genes related to Th2 inflammation in colon tissue form a large cohort of children with IBD. In addition, his laboratory is conducting ongoing studies with transgenic animal models to determine the mechanisms by which proteins important in perpetuating Th2 inflammatory responses contribute to inflammation in colitis.
Dr. Rosen serves on the National Pediatric Affairs Committee for the Crohn's & Colitis Foundation of America (CCFA). His a past recipient of the Fellow to Faculty Transition Award in IBD and the George Ferry Young Investigator Award from the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN).
MD: Harvard Medical School, Boston, MA, 2003.
Residency: Boston Combined Residency Program in Pediatrics (Boston Children's Hospital and Boston Medical Center), Boston, MA, 2003-2006.
Fellowship: Pediatric Gastroenterology, Hepatology, and Nutrition, Vanderbilt University Medical Center and the Monroe Carell, Jr. Children's Hospital at Vanderbilt, Nashville, TN 2006-2009.
Masters of Science in Clinical Investigation (MSCI): Vanderbilt University School of Medicine, Nashville, TN, 2009.
Certification: Pediatrics, 2007; Pediatric Gastroenterology, Hepatology and Nutrition, 2009.
Lu N, Lieu L, Van Kaer L, Washington MK, Rosen MJ, Dubé P, Wilson KT, Ren X, Hao X Polk DB, Yan F. Activation of the EGFR in macrophages regulates cytokine production and experimental colitis. The Journal of Immunology. 2014; 192(3):1013-23.
Falaiye TO, Mitchell KR, Lu Z, Saville BR, Horst SN, Moulton DE, Schwartz DA, Wilson KT, Rosen MJ. Outcome following infliximab therapy for pediatric patients hospitalized with refractory colitis-predominant inflammatory bowel disease. Journal of Pediatric Gastroenterology and Nutrition. 2014; 58(2):213-9.
Rosen MJ*, Chaturvedi R, Washington MK, Kuhnhein LA, Moore PD, Coggeshall SS, McDonough EM, Weitkamp JH, Singh AB. Coburn LA, Williams CS, Van Kaer L, Peebles RS, Wilson KT. STAT6 activation intensifies disease severity while increasing expression of claudin-2 and Th2-inducing cytokines in murine oxazolone colitis. The Journal of Immunology. 2013; 190(4):1849-1858.
Weitkamp JH, Koyama T, Rock MT, Correa H, Goettel J Matta P, Oswald-Richter K, Rosen MJ, Engelhardt BG, Moore D, Polk DB. Diminished mucosal regulatory (FOXP3+) / effector (CD4+, CD8+) T cell ratios as evidence for disrupted immune regulation in necrotizing enterocolitis. Gut. 2013; 62(1):73-82.
Rosen MJ, Denson LA, Kugathasan S. Commentaries on "Workshop report: developing a pediatric inflammatory bowel diseases network and data platform in Canada": pediatric inflammatory bowel disease networks: raising the bar. Journal of Pediatric Gastroenterology and Nutrition. 2012 Aug;55(2):121-2.
Rosen MJ*, Frey MR, Washington MK, Chaturvedi R, Kuhnhein LA, Matta P, Revetta F, Wilson KT, Polk DB. STAT6 activation in ulcerative colitis: A new target for prevention of IL-13-induced colonic epithelial cell dysfunction. Inflammatory Bowel Diseases. 2011; 17(11):2224-2234.
Rosen MJ, Schwartz DA. 31 Year-old with Colitis and Perianal Disease. Clinical Gastroenterology and Hepatology. 2010;8(1):10-4.
Rosen MJ, Moulton DE, Koyama T, Morgan WM, Morrow SE, Herline AJ, Muldoon RL, Wise PE, Polk DB, Schwartz DA. Endoscopic Ultrasound to Guide the Combined Medical and Surgical Management of Pediatric Perianal Crohn’s Disease. Inflammatory Bowel Diseases. 2010; 16(3):461-8.
Forcione DG, Rosen MJ, Kisiel JB, Sands BE. Anti-Saccharomyces cerevisiae antibody (ASCA) positivity is associated with increased risk for early surgery in Crohn's disease. Gut. 2004;53:1117-1122.
Sands BE, Arsenault JE, Rosen MJ, et al. Risk of Early Surgery for Crohn's Disease: Implications for Early Treatment Strategies. American Journal of Gastroenterology. 2003;98(12):2712-2718.
Th2 Cytokines and Signaling in Pediatric Inflammatory Bowel Disease. Principal Investigator. National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Diseases (NIH/NIDDK). Mar 2013-Mar 2018.
Myeloid Cell-Derived IL-33 in Chronic IL-10-Deficient Colitis. Principal Investigator. Cincinnati Children's Research Foundation. Jul 2014-Jun 2016.
Shehzad Ahmed Saeed, MD, FAAP, AGAF Clinical Director, Schubert–Martin Inflammatory Bowel Disease Center
Clinical Director, Schubert–Martin Inflammatory Bowel Disease Center
Clinical Director, Division of Gastroenterology, Hepatology and Nutrition
Medical Director, Gi/Colorectal Inpatient Unit
Associate Professor, UC Department of Pediatrics
Inflammatory bowel disease
Quality improvement in inflammatory bowel disease
Hocking MC, Barnes M, Shaw C, Lochman JE, Madan-Swain A, Saeed S. Executive function and attention regulation as predictors of coping success in youth with functional abdominal pain. J Pediatr Psychol. 2011 Jan;36(1):64-73.
Schaefer ME, Machan JT, Kawatu D, Langton CR, Markowitz J, Crandall W, Mack DR, Evans JS, Pfefferkorn MD, Griffiths AM, Otley AR, Bousvaros A, Kugathasan S, Rosh JR, Keljo DJ, Carvalho RS, Tomer G, Mamula P, Kay MH, Kerzner B, Oliva-Hemker M, Kappelman MD, Saeed SA, Hyams JS, Leleiko NS. Factors that determine risk for surgery in pediatric patients with Crohn's disease. Clin Gastroenterol Hepatol. 2010 Sep;8(9):789-94.
Malik TA, Saeed S. Autoimmune hepatitis: a review. J Pak Med Assoc. 2010 May;60(5):381-7. Wallander JL, Madan-Swain A, Klapow J, Saeed S. A randomised controlled trial of written self-disclosure for functional recurrent abdominal pain in youth. Psychol Health. 2010 Apr 21:1-15.
Imielinski M, Baldassano RN, Griffiths A, et.al. Common variants at five new loci associated with early-onset inflammatory bowel disease. Nat Genet. 2009 Dec;41(12):1335-40.
Colletti RB, Baldassano RN, Milov DE, Margolis PA, Bousvaros A, Crandall WV, Crissinger KD, D'Amico MA, Day AS, Denson LA, Dubinsky M, Ebach DR, Hoffenberg EJ, Kader HA, Keljo DJ, Leibowitz IH, Mamula P, Pfefferkorn MD, Qureshi MA; Pediatric IBD Network for Research and Improvement. Variation in care in pediatric Crohn disease. J Pediatr Gastroenterol Nutr. 2009 Sep;49(3):297-303. Maheshwari A, Kurundkar AR, Shaik SS, Kelly DR, Hartman Y, Zhang W, Dimmitt R, Saeed S, Randolph DA, Aprahamian C, Datta G, Ohls RK. Epithelial cells in fetal intestine produce chemerin to recruit macrophages. Am J Physiol Gastrointest Liver Physiol. 2009 Jul;297(1):G1-G10. Donnithorne KJ, Atkinson TP, Hinze CH, Nogueira JB, Saeed SA, Askenazi DJ, Beukelman T, Cron RQ. Rituximab therapy for severe refractory chronic Henoch-Schönlein purpura. J Pediatr. 2009 Jul;155(1):136-9. Haricharan RN, Proklova LV, Aprahamian CJ, Morgan TL, Harmon CM, Barnhart DC, Saeed SA. Laparoscopic cholecystectomy for biliary dyskinesia in children provides durable symptom relief. J Pediatr Surg. 2008 Jun;43(6):1060-4. Britton LJ, Saeed SA. Abdominal pain in cystic fibrosis. J Pediatr Health Care. 2008 Nov-Dec;22(6):383-6.
Richard A. Falcone Jr., MD, MPH Director, Trauma Services
Director, Trauma Services
Associate Professor, UC Department of Surgery
Pediatric injury prevention and outcomes; trauma education; management of colorectal disorders; inflammatory bowel disease; minimally invasive surgery; surgical oncology; extracorporeal life support (ECLS)
Injury prevention; health disparities; pediatric colorectal disorders; use of simulation to improve teamwork and safety
Nance ML, Krummel TM, Oldham KT, Falcone R JR, Trauma Committee of the American Pediatric Surgical Association. Firearm injuries and Children: A Policy Statement of the American Pediatric Surgical Association. J Am Coll Surg. 2013 Nov; 217(5): 940-6.
Patterson M, Geis G, Falcone R, LeMaster T, Wears R. In situ simulation: detection of safety threats and teamwork training in a high risk emergency department. BMJ Qual Saf. 2013 Jun;22(6):468-77.
Jurickova I, Collins MH, Chalk C, Seese A, Bezold R, Lake K, von Allmen D, Frischer JS, Falcone RA, Trapnell BC, Denson LA. Paediatric Crohn disease patients with stricturing behaviour exhibit ileal granulocyte-macrophage colony-stimulating factor (GM-CSF) autoantibody production and reduced neutrophil bacterial killing and GM-CSF bioactivity. Clin Exp Immunol. 2013 Jun;172(3)455-65.
Beaudin M, Maugans T, St-Vil D, Falcone RA Jr. Inappropriate use of infant seating devices increases risks of injury. J Pediatr Surg. 2013 May;48(5):1071-6.
Cook R, Gillespie GL, Kronk, R, Daugherty M, Moody SM, Allen LJ, Shebesta KB, Falcone RA. Effect of an Educational Intervention on Nursing Staff Knowledge, Confidence, and Practice in the Care of Children with Mild Traumatic Brain Injury. J Neurosci Nurs. 2013 Apr;45(2):108-18.
Kelleher DC, Renaud EJ, Ehrlich PF, Burd RS; Pediatric Trauma Society Guidelines Committee. Guidelines for alcohol screening in adolescent trauma patients: a report from the Pediatric Trauma Society Guidelines Committee. J Trauma Acute Care Surg. 2013 Feb;74(2):671-82.
Daugherty MC, Mehlman CT, Moody S, LeMaster T, Falcone RA Jr . Significant rate of misuse of the Hare traction splint for children with femoral shaft fractures. J Emerg Nurs. 2013 Jan;39(1):97-103.
Chatoorgoon K, Brown RL, Garcia VF, Falcone RA. Role of computed tomography and clinical findings in pediatric blunt intestinal injury: a multi-center study. Pediatr Emerg Care. 2012 Dec;28(12):1338-42.
Beaudin M, Daugherty M, Geis G, Moody S, Brown RL, Garcia VF, Falcone RA Jr. Assessment of factors associated with the delayed transfer of pediatric trauma patients: an emergency physician survey. Pediatr Emerg Care. 2012 Aug;28(8):758-63.
Falcone RA Jr, Haas L, King E, Moody S, Crow J, Moss A, Gaines B, McKenna C, Gourlay DM, Werner C, Meagher DP Jr, Schwing L, Garcia N, Brown D, Groner JI, Haley K, Deross A, Cizmar L, Armola R. A multicenter prospective analysis of pediatric trauma activation criteria routinely used in addition to the six criteria of the American College of Surgeons. J Trauma Acute Care Surg. 2012 Aug;73(2):377-84.
Jason S. Frischer, MD Director, Peña Colorectal Center
Director, Peña Colorectal Center
Director, Extracorporeal Membrane Oxygenation (ECMO) Program
Division of Pediatric General and Thoracic Surgery
Assistant Professor, UC Department of Surgery
Chernoguz A, Crawford, K, Vandersall A, Willson T, Denson LA, Frischer JS. Pre-treatment with Anti-VEGF therapy may exacerbate inflammation in experimental acute colitis. J Pediatr Surg. 2012 Feb;47(2):347-54.
Le LD, Keswani SG, Biesiada J, Lim FY, Kingma PS, Haberman BE, Frischer J, Habli M, Crombleholme TM. The congenital diaphragmatic hernia composite prognostic index correlates with survival in left-sided congenital diaphragmatic hernia. J Pediatr Surg. 2012 Jan;47(1):57-62.
Lawal TA, Falcone RA, von Allmen D, Denson LA, Levitt MA, Warner BW, Frischer JS. The utility of routine pouchogram before ileostomy reversal in children and adolescents following ileal pouch anal anastomosis. J Pediatr Surg. 2011 Jun;46(6):1222-5.
Chernoguz A, Crawford KM, Donovan EC, Vandersall AE, Berglund C, Cripe TP, Frischer JS. EGFR Inhibition Fails to Suppress Vascular Proliferation and Tumor Growth in a Ewing’s Sarcoma Model. J Surg Res. 2012 Mar;173(1):1-9.
Lawal TA, Frischer JS, Falcone RA, Chatoorgoon K, Denson LA, Levitt MA. The transanal approach with laparoscopy or laparotomy for the treatment of rectal strictures in Crohn’s disease. J Laparoendosc Adv Surg Tech A. 2010 Nov;20(9):791-5.
Bischoff A, Gupta A, D’Mello S, Mezoff A, Podberesky D, Barnett S, Keswani S, Frischer JS. Crohn’s disease limited to the appendix: a case report in a pediatric patient. Pediatr Surg Int. 2010 Nov;26(11):1125-8.
Vuletin JF, Lim FY, Cnota J, Kline-Fath B, Salisbury S, Haberman B, Kingma P, Frischer JS, Crombleholme T. Prenatal pulmonary hypertension index: novel prenatal predictor of severe postnatal pulmonary artery hypertension in antenatally diagnosed congenital diaphragmatic hernia. J Pediatr Surg. 2010 Apr;45(4):703-8.
Frischer JS, Lee A, Serur A, Huang J, Bae JO, Kornfield ZN, Eljuga L, Shawber CJ, Feirt N, Mansukhani M, Stempak D, Baruchel S, Bender JG, Kandel JJ, Yamashiro DJ. Inhibition of cyclooxygenase-2 disrupts tumor vascular mural cell recruitment and survival signaling. Cancer Res. 2006 Apr;66(8):4378-84.
Frischer JS, Huang J, Serur A, Kadenhe-Chiweshe A, McCrudden KW, O’Toole K, Holash J, Yancopoulos GD, Yamashiro DJ, Kandel JJ. Effects of potent VEGF blockade on experimental Wilms tumor and its persisting vasculature. Int J Onc. 2004 Sep;25(3):549-53.
Huang J, Frischer JS, Serur A, Kadenhe A, Yokoi A, McCrudden KW, New T, O’Toole K, Zabski S, Rudge JS, Holash J, Yancopoulos GD, Yamashiro DJ, Kandel JJ. Regression of established tumors and metastases by potent vascular endothelial growth factor blockade. Proc Natl Acad Sci USA. 2003 June 24;100(13):7785-90.
Daniel von Allmen, MD Director, Division of General and Thoracic Surgery
Director, Division of General and Thoracic Surgery
Professor, UC Department of Surgery
Pediatric surgical oncology; pediatric inflammatory bowel disease; surgical innovation; surgical robotics
Oncology; innovation; surgical workforce
Daniel von Allmen, MD, comes to Cincinnati from Chapel Hill, NC where he was the surgeon-in-chief and division chief at the North Carolina Children’s Hospital.
Dr. von Allmen completed his general surgery training at the University of Cincinnati and Cincinnati Children’s Hospital Medical Center. He is currently the Program Committee chair of the American Pediatric Surgical Association. He also serves on the Program Committee for the American Academy of Pediatrics Surgical Section and is a member of the Steering Committee for the Surgical Section of the Children’s Oncology Group.
Dr. von Allmen's special clinical interests include pediatric surgical oncology, pediatric inflammatory bowel disease, surgical innovation, and surgical robotics.
Mayer ML, Beil HA, von Allmen D. Distance to care and relative supply among pediatric surgical subspecialties. J Pediatr Surg. 2009;44:483-495.
Sandra Cortina, PhD Clinical Psychologist, Behavioral Medicine and Clinical Psychology
Clinical Psychologist, Behavioral Medicine and Clinical Psychology
Director of Clinical Services, Center for Adherence and Self-Management
Sandra Cortina, PhD, is an assistant professor of pediatrics in the Division of Behavioral Medicine and Clinical Psychology. She currently serves as a clinical faculty member and director of clinical service for the Center for the Promotion of Treatment Adherence and Self-Management.
Dr. Cortina provides leadership in the integration of clinical care and research as part of the center’s innovative clinical effectiveness program. She provides out-patient treatment to patients and families coping with a variety of chronic pediatric illness conditions. She specializes in adherence to medical treatment, behavioral concerns, and general psychosocial adjustment of patients and families. Specific out-patient services include providing cognitive behavioral and parent training strategies, follow-up of patient adjustment to new diagnosis, and utilizing motivational interviewing techniques.
Dr. Cortina also serves as a consultant to a multi-site, randomized control trial of an intervention to promote adherence to oral medication among adolescents with acute lymphoblastic leukemia, as well as an intervention to promote adherence among young adults with lupus. Finally, she is involved with Dr. Drotar in the development of several manuscripts pertaining to patient and family adjustment to chronic illness, as well as behavioral adherence to medical treatment.
Cortina SD, Drotar D, Ericksen M, Lindsey M, Patterson TL, Biagini Myers JM, Kovacic MB, Khurana Hershey GK. Genetic Biomarkers of Health-Related Quality of Life in Pediatric Asthma. J Pediatr. 2011 Feb 14. Cortina S, McGraw K, Dealarcon A, Ahrens A, Rothenberg ME, Drotar D. Psychological Functioning of Children and Adolescents With Eosinophil-Associated Gastrointestinal Disorders. Child Health Care. 2010 Oct;39(4):266-278.
Herzer M, Goebel J, Cortina S. Transitioning cognitively impaired young patients with special health needs to adult-oriented care: collaboration between medical providers and pediatric psychologists. Curr Opin Pediatr. 2010 Oct;22(5):668-72. Cortina S, Repaske DR, Hood KK. Sociodemographic and psychosocial factors associated with continuous subcutaneous insulin infusion in adolescents with type 1 diabetes. Pediatr Diabetes. 2010 Aug;11(5):337-44.
Kevin A. Hommel, PhD Clinical Psychologist, Behavioral Medicine and Clinical Psychology
Director, Divisional Data Core
Promotion of treatment adherence; self-management in pediatric chronic conditions
Adherence and self-management assessment methodology; behavioral treatment of nonadherence; promotion of self-management behavior; impact of adherence and self-management on health outcomes; quality of life in pediatric chronic conditions
Visit the Hommel Lab.
Dr. Hommel's research is currently funded by the National Institutes of Health: National Institute of Child Health and Human Development and National Institute of Diabetes and Digestive and Kidney Diseases. Many of his studies are focused on developing, testing (via randomized controlled trial), and optimizing behavioral treatments for nonadherence in inflammatory bowel disease (IBD), as well as examining the effects of nonadherence on disease outcomes and health-related quality of life (HRQoL). Dr. Hommel is also involved in studies that are aimed at developing HRQoL measures in functional gastrointestinal disorders (FGID) and eosinophilic esophagitis. He is a co-investigator on the PROTECT study, which is a multisite U01 study aimed at defining the rate of corticosteroid-free remission in pediatric patients with ulcerative colitis receiving standardized medical therapy. Additionally, Dr. Hommel is a co-investigator on a multisite R01 study aimed at developing and testing a collaborative chronic care network (C3N) to improve treatment outcomes in children with IBD.
Dr. Hommel came to Cincinnati Children's Hospital Medical Center in 2008 from the Children's Hospital of Philadelphia and the University of Pennsylvania School of Medicine. He continues to collaborate with investigators at the Children's Hospital of Philadelphia as a site principal investigator on two studies funded by the NIDDK. The first is evaluating the efficacy of a low magnitude mechanical stimulus intervention to improve bone mineral density in children with Crohn's disease and the second is examining the effects of a novel lipid matrix supplement on choline status in children with cystic fibrosis.
Hommel KA, Franciosi JP, Gray WN, Hente EA, Ahrens A, Rothenberg ME. Behavioral functioning and treatment adherence in pediatric eosinophilic gastrointestinal disorders. Pediatric Allergy and Immunology. (in press).
Franciosi JP, Hommel KA, DeBrosse CW, Greenler AJ, Greenberg AB, Abonia JP, Rothenberg ME, Varni JW. Quality of Life in Paediatric Eosinophilic Oesophagitis: What is Important to Patients? Child: Care, Health, and Development. 38(4): 477-483. 2012.
Hommel KA, Hente EA, Odell S, Herzer M, Ingerski LM, Guilfoyle SM, Denson LA. Evaluation of a Group-Based Behavioral Intervention to Promote Adherence in Adolescents with Inflammatory Bowel Disease. European Journal of Gastroenterology and Hepatology. 24(1): 64-69. 2012.
Gray WN, Denson LA, Baldassano RN, Hommel KA. Treatment Adherence in Adolescents with Inflammatory Bowel Disease: The Collective Impact of Barriers to Adherence and Anxiety/Depressive Symptoms. Journal of Pediatric Psychology. 37(3): 282-291. 2012.
Hommel KA, Franciosi JP, Hente EA, Ahrens A, Rothenberg ME. Treatment Adherence in Pediatric Eosinophilic Gastrointestinal Disorders. Journal of Pediatric Psychology. 37(5): 533-542. 2012.
Modi AC, Pai AL, Hommel KA, Hood KK, Cortina S, Hilliard ME, Guilfoyle SM, Gray WN, Drotar D. Pediatric self-management: A framework for research, practice, and policy. Pediatrics. 129(2): E473-485. 2012.
Guilfoyle SM, Denson LA, Baldassano RN, Hommel KA. Paediatric parenting stress in inflammatory bowel disease: Application of the Pediatric Inventory for Parents. Child: Care, Health and Development. 38(2): 273-279. 2012.
Hommel KA, Herzer M, Ingerski LM, Hente EA, Denson LA. Individually-tailored treatment of medication nonadherence: A pilot study. Journal of Pediatric Gastroenterology and Nutrition. 2011.
Herzer M, Denson LA, Baldassano RN, Hommel KA. Family functioning and health-related quality of life in adolescents with pediatric inflammatory bowel disease. Eur J Gastroenterol Hepatol. Jan;23(1):95-100. 2011.
Hommel KA, Odell S, Sander E, Baldassano RN, Barg FK. Treatment adherence in paediatric inflammatory bowel disease: perceptions from adolescent patients and their families. Health Soc Care Community. Jan;19(1):80-8. 2011.
Open Source Science: Transforming Chronic Illness Care. Co-Investigator. National Institute of Diabetes and Digestive and Kidney Diseases / National Institute of Nursing Research. 2009-2014.
Telehealth Enhancement of Adherence to Medication in Pediatric IBD (TEAM Study). Principal Investigator. National Institutes of Health / National Institute of Child Health and Human Development. 2011-2016.
Predicting Response to Standard Pediatric Colitis Therapy: The PROTECT study. Co-Investigator. National Institute of Diabetes and Digestive and Kidney Diseases. 2012-2017.
Michael W. Mellon, PhD, ABPP Clinical Psychologist, Behavioral Medicine and Clinical Psychology
Acceptance and Commitment Therapy (ACT) application to children with IBD and their families
The development of child and parent self-report measures of experiential avoidance and cognitive fusion related to IBD
Michael W. Mellon, PhD, earned his PhD from the University of Memphis and completed an internship at the University of Mississippi Medical Center. Dr. Mellon is currently a pediatric psychologist in the Department of Pediatrics at Cincinnati Children’s Hospital Medical Center providing psychological care to patients with inflammatory bowel disease (IBD).
Dr. Mellon has also worked in the Department of Psychiatry and Psychology at the Mayo Clinic as the co-director of the Mayo Clinic-Dana Child Development and Learning Disorders Program, and director of the Enuresis and Encopresis Clinic. Dr. Mellon has published and presented papers at national conferences in the areas of behavioral treatments for enuresis and encopresis.
Recent research activities include a study of the relationship between ADHD and elimination disorders, and a study identifying predictors of outcome in conditioning treatment of primary nocturnal enuresis.
Homan KJ, Mellon MW, Houlihan D, Katusic MZ. Brief Report: Childhood Disintegrative Disorder: A Brief Examination of Eight Case Studies. J Autism Dev Disord. 2011 Apr;41(4):497-504.
Voigt RG, Johnson SK, Mellon MW, Hashikawa AH, Campeau LJ, Williams AR, Yawn BP, Juhn YJ. Relationship between parenting stress and concerns identified by developmental screening and their effects on parental medical care-seeking behavior. Clin Pediatr (Phila). 2009 May;48(4):362-8.
Voigt RG, Johnson SK, Hashikawa AH, Mellon MW, Campeau LJ, Williams AR, Yawn BP, Juhn YJ. Why parents seek medical evaluations for their children with mild acute illnesses. Clin Pediatr (Phila). 2008 Apr;47(3):244-51.
Mellon MW, Whiteside SP, Friedrich WN. The relevance of fecal soiling as an indicator of child sexual abuse: a preliminary analysis. J Dev Behav Pediatr. 2006 Feb;27(1):25-32.
Lynn SG, Bauch CD, Williams DE, Beatty CW, Mellon MW, Weaver AL. Psychologic profile of tinnitus patients using the SCL-90-R and Tinnitus Handicap Inventory. Otol Neurotol. 2003 Nov;24(6):878-81.
Bauch CD, Lynn SG, Williams DE, Mellon MW, Weaver AL. Tinnitus impact: three different measurement tools. J Am Acad Audiol. 2003 May-Jun;14(4):181-7.
McGrath ML, Mellon MW, Murphy L. Empirically supported treatments in pediatric psychology: constipation and encopresis. J Pediatr Psychol. 2000 Jun;25(4):225-54; discussion 255-6. Review.
Mellon MW, McGrath ML. Empirically supported treatments in pediatric psychology: nocturnal enuresis. J Pediatr Psychol. 2000 Jun;25(4):193-214; discussion 215-8, 219-24. Review.
Stern HP, Stroh SE, Fiedorek SC, Kelleher K, Mellon MW, Pope SK, Rayford PL. Increased plasma levels of pancreatic polypeptide and decreased plasma levels of motilin in encopretic children. Pediatrics. 1995 Jul;96(1 Pt 1):111-7.
Stern HP, Mellon MW, Stern TP, Fiser R. Information highway travelling back to our roots. J Ark Med Soc. 1994 Dec;91(7):316-7.
Kenneth R. Goldschneider, MD, FAAP Director, Pain Management Center
Director, Pain Management Center
Professor, UC Department of Anesthesia
Complex chronic pain conditions in infants, children and young adults, including those related to vascular malformations, epidermolysis bullosa and cancer.
Outcomes of pain treatment, with a focus on outpatient, chronic pain management.
Lynch-Jordan AM, Kashikar-Zuck S, Goldschneider KR. Parent perceptions of adolescent pain expression: the adolescent pain behavior questionnaire. Pain. 2010 Dec;151(3):834-42.
Goldschneider K, Lucky AW, Mellerio JE, Palisson F, del Carmen Viñuela Miranda M, Azizkhan RG. Perioperative care of patients with epidermolysis bullosa: proceedings of the 5th international symposium on epidermolysis bullosa, Santiago Chile, December 4-6, 2008. Paediatr Anaesth. 2010 Sep;20(9):797-804.
Goldschneider KR, Lucky AW. Pain management in epidermolysis bullosa. Dermatol Clin. 2010 Apr;28(2):273-82, ix. Review.
Meyer MJ, Goldschneider KR, Bielefeldt K, Zeltzer L, Lackner J, Keefer L. Functional abdominal pain in adolescence: a biopsychosocial phenomenon. J Pain. 2008 Nov;9(11):984-90.
Hosu L, Meyer MJ, Goldschneider KR. Cerebrospinal fluid cutaneous fistula after epidural analgesia in a child. Reg Anesth Pain Med. 2008 Jan-Feb;33(1):74-6.
Goldschneider KR, Racadio JM, Weidner NJ. Celiac plexus blockade in children using a three-dimensional fluoroscopic reconstruction technique: case reports. Reg Anesth Pain Med. 2007 Nov-Dec;32(6):510-5.
Lynch AM, Kashikar-Zuck S, Goldschneider KR, Jones BA. Sex and age differences in coping styles among children with chronic pain. J Pain Symptom Manage. 2007 Feb;33(2):208-16.
Lynch AM, Kashikar-Zuck S, Goldschneider KR, Jones BA. Psychosocial risks for disability in children with chronic back pain. J Pain. 2006 Apr;7(4):244-51.
Kashikar-Zuck S, Vaught MH, Goldschneider KR, Graham TB, Miller JC. Depression, coping, and functional disability in juvenile primary fibromyalgia syndrome. J Pain. 2002 Oct;3(5):412-9.
Kashikar-Zuck S, Goldschneider KR, Powers SW, Vaught MH, Hershey AD. Depression and functional disability in chronic pediatric pain. Clin J Pain. 2001 Dec;17(4):341-9.
Alexandra Szabova, MD Director, Pain Management Fellowship
Director, Pain Management Fellowship
Assistant Professor, UC Department of Anesthesia
Chronic pediatric pain management; chronic pediatric and adolescent back and musculoskeletal pain management; acute pain management; pediatric regional anesthesia techniques; interventional pain management; pediatric anesthesia
Alexandra Szabova, MD, joined the staff of Cincinnati Children's Hospital Medical Center in 2006. She has worked as a pediatric anesthesiologist but also became a team member of the multidisciplinary chronic pediatric pain clinic.
Dr. Szabova demonstrated strong interest in pediatric chronic pain management during her training. She graduated from a combined pediatric and adult chronic pain management fellowship which was a result of close collaboration between the Cincinnati Children's and Cleveland Clinic Foundation, Cleveland, OH.
Dr. Szabova received her medical degree from the Comenius University in Bratislava, Slovakia, and completed her residency in anesthesia at the Cleveland Clinic Foundation, Cleveland, OH.
Dr. Szabova completed her combined pediatric and adult chronic pain management at Cincinnati Children's and Cleveland Clinic Foundation where is served as a chief fellow. She graduated with The Pain Fellow of the Year Award. Dr. Szabova completed pediatric anesthesia fellowship at the Cincinnati Children's.
Dr. Szabova's interests include chronic pediatric pain management, musculoskeletal pain in children and adolescents, acute pain management of surgical and non surgical pediatric patients, regional nerve blocks, and pediatric anesthesia.
MD: Comenius University, Bratislava, Slovakia, 1995.
Residency: Anesthesiology, Cleveland Clinic Foundation, Cleveland, OH.
Fellowship: Pain Management, Cleveland Clinic Foundation, Cleveland, OH; Pediatric Anesthesia, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
Certification: Anesthesiology, 2005; ABA Pain Medicine, 2005.
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