• Expertise in Treating Rare Disorders

    The Immune Deficiency and Histiocytosis Program at Cincinnati Children’s treats patients with more than 80 kinds of immune deficiency and histiocytic disorders. Our physicians have developed treatment regimens that improve survival and are now the international standard of care. These specialists manage each stage of patient care, from immunologic testing to bone marrow transplant, if needed.

    These diseases are rare, but our specialists have extensive experience in their diagnosis and management.

    Among the immune deficiencies and histiocytic disorders we diagnose and treat:

    • ALPS (autoimmune lymphoproliferative syndrome)
    • HIGM2-HIGM4 (autosomal recessive hyper IgM syndrome)
    • CGD (chronic granulomatous disease)
    • CVID (common variable immunodeficiency)
    • HLH (hemophagocytic lymphohistiocytosis)
    • Hypogammaglobulinemia
    • IPEX (immune dysregulation, polyendocrinopathy, enteritis, X-linked)
    • LCH (Langerhans cell histiocytosis)
    • SCIDs (severe combined immunodeficiencies)
    • XLA (X-linked agammaglobulinemia)
    • HIM (X-linked-hyper IgM syndrome / X-linked CD40 ligand deficiency)
    • XLP (X-linked lymphoproliferative syndrome)
    • NEMO (X-linked NFkB essential modifier deficiency)
    • WAS (Wiskott-Aldrich syndrome)
  • Bone Marrow Transplant

    We have one of the nation’s largest transplant centers. Our multidisciplinary team has performed more than 1,300 transplants in the program’s 20-year history.

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  • Patient Stories

    Learn more about other patients who have come to Cincinnati Children's for treatment, including Hannah and her successful battle with HLH.

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