Immune Deficiency and Histiocytosis

  • Meet the Team

    The Immune Deficiency and Histiocytosis Program is home to specialists with a wide variety of backgrounds and areas of focus. As a team, this diversity makes us better prepared to care for your child’s unique needs. Learn more about our faculty and staff.

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    Director

    A photo of Lisa Filipovich.

    Alexandra (Lisa) H. Filipovich, MD
    Ralph J. Stolle Chair, Clinical Immunology

    513-803-3218

    lisa.filipovich@cchmc.org

    Alexandra (Lisa) H. Filipovich, MD

    Ralph J. Stolle Chair, Clinical Immunology

    Director, Immune Deficiency and Histiocytosis Program

    Medical Director, Diagnostic Immunology Laboratory

    Professor, UC Department of Pediatrics

    Phone: 513-803-3218

    Fax: 513-803-1969

    Email: lisa.filipovich@cchmc.org

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    Specialties

    Clinical Interests

    Primary immunodeficiencies; BMT for primary immunodeficiencies; hemophagocytic lymphocytosis; post-BMT immune reconstruction

    Research Interests

    Biology and genetics of hemophagocytic lymphohistiocytosis; investigation of hematopoietic cell transplantation for genetic immunodeficiencies; immunoreconstitution following pediatric stem cell transplantation

    Biography

    Lisa Filipovich, MD, began her career at the University of Minnesota where she received her medical degree in 1974 and completed fellowships in both immunopathology and pediatric immunology. She became a professor of pediatrics and served for 10 years as the head of the Division of Immunology at the University of Minnesota Medical School. Dr. Filipovich came to Cincinnati Children’s in 1996. She is currently the Ralph J. Stolle Chair in Clinical Immunology and the director of the Immune Deficiency and Histiocytosis program. She also serves as the medical director of the Diagnostic Immunology Laboratory at Cincinnati Children’s.

    Dr. Filipovich has a special interest in histiocytic disorders, especially hemophagocytic lymphohistiocytosis (HLH). Other interests include bone marrow transplant for primary immune deficiencies and post-BMT immune reconstitution. She serves as president of the Histiocyte Society, an international group of more than 200 physicians and scientists who are committed to improving the lives of patients with histiocytosis through research.

    Education and Training

    MD: University of Minnesota, Minneapolis, MN, 1974.

    Residency: University of Minnesota Hospitals, Minneapolis, MN 1975-1978.

    Fellowship: Immunopathology, Departments of Pediatrics, Laboratory Medicine and Pathology, University of Minnesota 1978-1979.

    Fellowship: Pediatric Immunology, Department of Pediatrics, University of Minnesota 1979-1980.

    Certification: Pediatrics, 1980.

    Publications

    View PubMed Publications

    Grants

    Gene Therapy for SCID-X1 Using Self-Inactivating Gamma. Principal Investigator. National Institutes of Health. Sep 2010-Aug 2015. #U01 AI 087628.

    Rare Diseases Clinical Consortia for the Rare Diseases. Principal Investigator. National Institutes of Health. Sep 2009-Aug 2014. #U54 AI 082973.

    Hypoxia and potassium channel activity in T Lymphocytes. Principal Investigator. National Institutes of Health. Jun 2009-Jun 2014. #R01 CA 095286.

    Faculty

    Jacob (Jack) J.H. Bleesing, MD, PhD

    Associate Professor, UC Department of Pediatrics

    Phone: 513-636-4266

    Fax: 513-636-3549

    Email: jack.bleesing@cchmc.org

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    Specialties

    Clinical Interests

    Immunobiology; translational research; immunologic methods development

    Research Interests

    Clinical investigation of primary immunodeficiency disorders (with emphasis on disorders of immuno dysregulation and B-cell disorders); immuno-reconstitution following blood and marrow transplantation; diagnostic immunology (with emphasis on flow cytometry) 

    Education and Training

    MD: University of Leiden, Leiden, The Netherlands, 1989.

    PhD: University of Leiden, Leiden, The Netherlands, 2002.

    Residency: Pediatrics, University of Florida, Gainesville, Florida, 1993.

    Fellowship: Allergy/Immunology, Duke University Medical Center, Durham, North Carolina, 1995.

    Fellowship: Clinical Laboratory Immunology, National Institutes of Health, Bethesda, Maryland, 2001.

    Publications

    View PubMed Publications

    Michael B. Jordan, MD

    Associate Professor, UC Department of Pediatrics

    Phone: 513-636-7287

    Fax: 513-803-1969

    Email: michael.jordan@cchmc.org

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    Specialties

    Clinical Interests

    Histiocytic disorders: HLH and LCH

    Research Interests

    Better understanding histiocytic disorders and developing novel therapies for them; regulation of the immune response; immunotherapy of cancer

    Education and Training

    MD: UT Southwestern, Dallas, TX, 1993.

    Residency: Children's Hospital of Dallas, 1996.

    Fellowship: The Children's Hospital (Denver), 2002.

    Certification: American Board of Pediatrics, 1996; Sub-board of Pediatric Heme/Onc, 2002.

    Publications

    View PubMed Publications

    Ashish R. Kumar, MD, PhD

    Associate Professor, UC Department of Pediatrics

    Phone: 513-803-1631

    Fax: 513-636-3549

    Email: ashish.kumar@cchmc.org

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    Specialties

    Clinical Interests

    Childhood cancer and blood disorders; immune deficiency

    Research Interests

    Leukemia biology; cancer biology

    Visit the Kumar Lab.

    Biography

    Dr. Kumar received his medical degree from L.T.M. Medical College, Mumbai, India, his PhD in anatomy and cell biology from the University of Iowa, pediatric residency training at the Mayo Clinic and fellowship in pediatric hematology / oncology / BMT at the University of Minnesota. He was appointed to the faculty of the University of Minnesota in the Department of Pediatrics where he was a member of the programs in pediatric leukemia and global pediatrics. As a faculty of the Masonic Cancer Center, he was also part of the Genetic Mechanisms of Cancer research program. Dr. Kumar’s laboratory is engaged in researching the biology of infant leukemia. Discoveries made in his laboratory have significantly enhanced the current understanding of leukemia.

    Education and Training

    MD: LTM Medical College, Mumbai, India.

    Residency: Mayo Clinic, Rochester, MN.

    Fellowship: University of Minnesota, Minneapolis, MN.

    PhD: University of Iowa, Iowa City, IA.

    Certification: General Pediatrics; Pediatric Hematology/Oncology Subspecialty.

    Licenses: State of Ohio; State of Minnesota.

    Publications

    View PubMed Publications
    A photo of Rebecca Marsh.

    Rebecca A. Marsh, MD

    Assistant Professor, UC Department of Pediatrics

    Phone: 513-803-9063

    Email: rebecca.marsh@cchmc.org

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    Education and Training

    Fellowship: Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, 2008.

    Residency: Rush University Medical Center, Chicago, Illinois, 2006.

    MD: Rush Medical College 2003.

    BS: University of Tennessee, Knoxville, Tennessee, 1998.

    Publications

    View PubMed Publications

    Grants

    Studies to Determine why XIAP Deficiency leads to HLH. Clinical Immunology Society. Jul 2010 - Jun 2012,

    Joseph S. Palumbo, MD

    Associate Professor, UC Department of Pediatrics

    Phone: 513-636-4266

    Fax: 513-636-3549

    Email: joe.palumbo@cchmc.org

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    Specialties

    Interactions between the hemostatic system and innate immunity effecting tumor progression; Langerhans' cell histiocytosis

    Education and Training

    MD: Pennsylvania State University College of Medicine, Hershey, PA, 1993. 

    Residency: Childrens Hospital Medical Center, Cincinnati, OH, 1997. 

    Fellowship: Childrens Hospital Medical Center, Cincinnati, OH, 2000.

    Subspecialty: Pediatric Hematology / Oncology.

    Publications

    View PubMed Publications

    Grants

    Mechanisms Linking Metastasis to Tumor Procoagulant and Innate Immunity. Principal Investigator. National Institutes of Health. Jul 2006 - Jun 2012. #R01HL085545.
    A photo of Kimberly Risma.

    Kimberly A. Risma, MD, PhD
    Director, Allergy and Immunology Fellowship Program

    513-636-6771

    kimberly.risma@cchmc.org

    Kimberly A. Risma, MD, PhD

    Director, Allergy and Immunology Fellowship Program

    Assistant Professor, UC Department of Pediatrics

    Phone: 513-636-6771

    Fax: 513-636-4615

    Email: kimberly.risma@cchmc.org

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    Specialties

    Clinical Interests

    Immune deficiency; immune dysregulation

    Research Interests

    Pathophysiology of perforin missense mutations identified in individuals with hemophagocytic lymphohistiocytosis; molecular mechanisms of primary immune deficiency and dysregulation; natural killer cell and cytotoxic T lymphocyte cytotoxicity

    Visit the Risma Lab website.

    Biography

    Kimberly Risma, MD, PhD, is an assistant professor in the Division of Allergy and Immunology at Cincinnati Children’s and the University of Cincinnati College of Medicine.

    Dr. Risma graduated magna cum laude with a Bachelor of Arts in Chemistry from Duke University in 1990 and was elected into The Phi Beta Kappa Society. She then matriculated at Case Western Reserve University (CWRU) School of Medicine in the Medical Scientist Training Program (MSTP). In 1996, she completed a PhD in pharmacology. She was selected by the leadership of the CWRU MSTP as the recipient of the 1997 Martin Wahl Memorial Fund Award, given annually to recognize the graduating MD, PhD student who has demonstrated the highest level of independence in research and excellence in research and clinical skills. She was also elected to Alpha Omega Alpha Society in 1997.

    In 1997, she enrolled in a Pediatrics residency at Cincinnati Children’s Hospital Medical Center/University of Cincinnati.  During the residency program, Dr. Risma was awarded the pediatric resident teaching award by the medical students. She also engaged in translational research studies related to the genetics of asthma under the mentorship of Dr. Gurjit Hershey, resulting in a first author publication as a pediatric resident.

    In 2000, Dr. Risma was accepted to the Allergy and Immunology Fellowship Program at Cincinnati Children’s.  In addition to her clinical training, she pursued an innovative research project under the mentorship of Dr. Janos Sumegi and Dr. Alexandra Filipovich. She proposed a mechanism to study the structural and functional impact of perforin missense mutations identified in patients with hemophagocytic lymphohistiocytosis. In 2004 she was awarded the Nezelof Prize for best scientific presentation at the international meeting of the Histiocyte Society. The culmination of her fellowship research project was published in the Journal of Clinical Investigation, 2006.  

    Upon completion of her fellowship in 2005, Dr. Risma was appointed as an Assistant Professor in the Division of Allergy and Immunology at Cincinnati Children’s Hospital Medical Center. In 2006 Dr. Risma received a Clinical Scientist Development Award from the Doris Duke Charitable Foundation. Dr. Risma is the director of the Allergy and Immunology Fellowship Program at Cincinnati Children's, having served in this leadership position since August of 2012.

    Dr. Risma's research program focuses on understanding the molecular mechanisms of immunodeficiency and immune dysregulation in children, especially as it relates to disorders of lymphocyte cytotoxicity. In addition to her research, she sees patients from all around the country in consultation for primary immune deficiency, immune dysregulation, and allergic disorders.   

    Education and Training

    MD: Case Western Reserve University School of Medicine, Cleveland, OH, 1997.

    PhD: Case Western Reserve University School of Medicine, Cleveland, OH, 1996.

    Residency: Pediatrics, Cincinnati Children's Hospital Medical Center, 1997-2000.

    Fellowship: Allergy / Immunology, Cincinnati Children's Hospital Medical Center.

    Certification: Pediatrics, 2007; Allergy and Immunology, 2005.

    Publications

    View PubMed Publications

    Laboratory Researchers

    A photo of Lee Grimes.

    H. Leighton (Lee) Grimes, PhD
    Director, Cancer Pathology Program of the Division of Experimental Hematology and the Division of Pathology

    513-636-6089

    lee.grimes@cchmc.org

    H. Leighton (Lee) Grimes, PhD

    Director, Cancer Pathology Program of the Division of Experimental Hematology and the Division of Pathology

    Co-Leader, Program in Hematologic Malignancies of Cincinnati Children's Hospital Medical Center, Cancer and Blood Diseases Institute

    Associate Professor, UC Department of Pediatrics

    Phone: 513-636-6089

    Fax: 513-636-5355

    Email: lee.grimes@cchmc.org

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    Specialties

    Transcriptional control of hematopoiesis and cancer.

    Visit the Grimes Lab.

    Biography

    Grimes Laboratory:

    The cloning and characterization of oncoproteins and tumor suppressors over the last 25 years has not only resulted in a greater understanding of the molecular mechanisms of transformation, but it has also provided a large set of therapeutic targets. Our lab is interested in the progression of a cell with a single genetic lesion to an invasive cancer with multiple genetic alterations. We focus on the Growth factor independence-1 (Gfi1) transcription factor, which is poorly oncogenic alone, but which potently collaborates with well known oncoproteins such as c-MYC. Gfi1 is the most frequently targeted gene in Moloney murine leukemia virus-induced tumors and induces tumor progression to cytokine-independent growth. In contrast, loss of Gfi1 in hematopoietic stem cells induces cell cycle progression and eventual bone marrow failure; implicating Gfi1 as a tumor suppressor in such cells. Gfi1 null mice have no mature neutrophils, and we have identified humans with Severe Congenital Neutropenia (SCN) and Non-Immune Chronic Idiopathic Neutropenia of Adults (NI-CINA) bearing mutations in Gfi1. Interestingly, such patients are at increased risk for the development of myelodysplastic syndromes and acute myeloid leukemia. We have recently generated the first mouse model of Severe Congenital Neutropenia through the expression of mutant Gfi1 proteins in primary murine hematopoietic cells. Moreover, we are utilizing mouse models of human cancer to assess the risk of Gfi1 mutant humans for the development of acute myeloid leukemia.

    Education and Training

    PhD: Immunology and Molecular Pathology, University of Florida, Gainesville, FL.

    Postdoctoral Fellow: Fox Chase Cancer Center.

    Publications

    View PubMed Publications

    Janos Sumegi, MD, PhD

    Professor, UC Department of Pediatrics

    Phone: 513-636-5976

    Fax: 513-636-3549

    Email: janos.sumegi@cchmc.org

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    Specialties

    Lymphoproliferative disease; hemophagocytic lymphohistiocytosis; usher syndrome

    Education and Training

    MD: University Medical School of Debrecen, Hungary, 1968.

    PhD: Research Center of the Hungarian Academy of Science, Budapest, Hungary, 1974.

    Docent (DMSc): Karolinska Institute Stockhom, Sweden, 1982.

    Publications

    View PubMed Publications

    Grants

    Gene-Expression Profiling of Peripheral Blood Mononuclear Cells in Hemophagocytic Lymphohistiocytosis. Histiocytosis Association of America. Dec 2010 - Nov 2011. 


    Nurse Practitioners

    A photo of Paula Cuthrell.

    Paula Cuthrell, MSN, APRN, CFNP
    Nurse Practitioner, Interventional Radiology

    513-803-1147

    paula.cuthrell@cchmc.org

    Paula Cuthrell, MSN, APRN, CFNP

    Nurse Practitioner, Interventional Radiology

    Phone: 513-803-1147

    Fax: 513-636-6735

    Email: paula.cuthrell@cchmc.org

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    Education and Training

    BA: Biology, Thomas More College, Crestview Hills, KY, 1980.

    BSN: Thomas More College, Crestview Hills, KY, 1982.

    MSN: Family nurse practitioner, Northern Kentucky University, Cold Spring, KY, 1996.

    Credentials:
    American Nurses Credentialing Center (ANCC), certified family nurse practitioner; Ohio Board of Nursing Certificate of Authority, 1996.

    No photo available

    Jennifer Detzel, MSN, APRN, CFNP
    Nurse Practitioner, Immune Deficiencies and Histiocytosis

    513-636-8402

    jennifer.detzel@cchmc.org

    No photo available

    Jennifer Detzel, MSN, APRN, CFNP

    Nurse Practitioner, Immune Deficiencies and Histiocytosis

    Phone: 513-636-8402

    Email: jennifer.detzel@cchmc.org

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    Education and Training

    MSN: University of Cincinnati, Cincinnati, OH, 2005.

    Certification: ANCC, Certified Family Nurse Practitioner, 2005.


    No photo available

    Mary Ann Michael, APRN, CNP
    Pediatric Nurse Practitioner, Regional Center for Newborn Intensive Care

    513-636-4466

    maryann.michael@cchmc.org

    No photo available

    Mary Ann Michael, APRN, CNP

    Pediatric Nurse Practitioner, Regional Center for Newborn Intensive Care

    Phone: 513-636-4466

    Email: maryann.michael@cchmc.org