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Department Head

Margaret K. Hostetter, MD
Director, Infectious Diseases

513-636-4509

margaret.hostetter@cchmc.org

Faculty

Rebecca C. Brady, MD
Director, Adult Clinical Services

513-636-4578

rebecca.brady@cchmc.org

Rebecca C. Brady, MD

Director, Adult Clinical Services

Assistant Professor, UC Department of Pediatrics

Phone: 513-636-4578

Email: rebecca.brady@cchmc.org

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Specialties

Clinical Interests

Adult and pediatric infectious disease

Research Interests

Cytomegalovirus and other viral infections

Education and Training

MD: University of Kentucky, Lexington, KY, 1988.

Residency: Internal Medicine/Pediatrics, University of Louisville, Louisville, KY.

Fellowships: Pediatric Infectious Diseases, Children's Hospital Medical Center, Cincinnati, Ohio; Adult Infectious Diseases, University of Cincinnati, Cincinnati, OH.

Certifications: Pediatrics, 1992, recertified 1999; Internal Medicine, 1993; Pediatric Infectious Diseases, 1997; Adult Infectious Diseases, 1997.

Publications

View PubMed Publications

Subbramanian RA, Basha S, Shata MT, Brady RC, Bernstein DI. Pandemic and seasonal H1N1 influenza hemagglutinin-specific T cell responses elicited by seasonal influenza vaccination. Vaccine. 2010 Dec 6;28(52):8258-67.

Brady RC. Influenza. Adolesc Med State Art Rev. 2010 Aug;21(2):236-50, viii.

Subbramanian RA, Basha S, Brady RC, Hazenfeld S, Shata MT, Bernstein DI. Age-related changes in magnitude and diversity of cross-reactive CD4+ T-cell responses to the novel pandemic H1N1 influenza hemagglutinin. Hum Immunol. 2010 Oct;71(10):957-63.

Brady RC, Treanor JJ, Atmar RL, Keitel WA, Edelman R, Chen WH, Winokur P, Belshe R, Graham IL, Noah DL, Guo K, Hill H. Safety and immunogenicity of a subvirion inactivated influenza A/H5N1 vaccine with or without aluminum hydroxide among healthy elderly adults. Vaccine. 2009 Aug 13;27(37):5091-5.

de Bruyn G, Vargas-Cortez M, Warren T, Tyring SK, Fife KH, Lalezari J, Brady RC, Shahmanesh M, Kinghorn G, Beutner KR, Patel R, Drehobl MA, Horner P, Kurtz TO, McDermott S, Wald A, Corey L. A randomized controlled trial of a replication defective (gH deletion) herpes simplex virus vaccine for the treatment of recurrent genital herpes among immunocompetent subjects. Vaccine.2006; 24:914-20.

Treanor JJ, Schiff GM, Couch RB, Cate TR, Brady RC, Hay M, Wolff M, She D, Cox MMJ. Dose-related safety and immunogenicity of a trivalent baculovirus-expressed influenza-virus hemagglutinin vaccine in elderly adults. Journal of Infectious Diseases. 2006; 193:1223-8.

Treanor JJ, Schiff GM, Hayden FG, Brady RC, Hay CM, Meyer AL, Holden-Wiltse J, Liang H, Gilbert A, Cox M. Safety and immunogenicity of a baculovirus-expressed hemagglutinin influenza vaccine: a randomized controlled trial. Journal of the American Medical Association. 2007; 297:1577-82.

Couch RC, Winokur P, Brady RC, Belshe R, Chen WH, Cate TR, Sigurdardottir B, Hoeper A, Graham IL, Edelman R, He F, Nino D, Capellan J, Ruben FL. Safety and immunogenicity of a high dosage trivalent influenza vaccine among elderly subjects. Vaccine. 2007; 25:7656-63.

Beverly Connelly is Director of the Infection Control Program.

Beverly L. Connelly, MD
Director, Infection Control Program

513-636-8492

beverly.connelly@cchmc.org

Lara A. Danziger-Isakov, MD, MPH
Adjunct Staff, James M. Anderson Center for Health Systems Excellence

513-636-4578

lara.danziger-isakov@cchmc.org

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Lara A. Danziger-Isakov, MD, MPH

Adjunct Staff, James M. Anderson Center for Health Systems Excellence

Associate Professor, UC Department of Pediatrics

Phone: 513-636-4578

Email: lara.danziger-isakov@cchmc.org

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Specialties

Transplant infectious diseases

Biography

Dr. Danziger-Isakov began her research career investigating cytomegalovirus in pediatric lung transplant recipients. After completing fellowship she led an international epidemiological study of pediatric lung transplant recipients including 14 international sites from North America and Europe to publish seminal manuscripts on fungal and viral infections through the International Pediatric Lung Transplant Collaborative. While at the Cleveland Clinic she performed an innovative investigation evaluating alloreactive cellular and humoral responses to influenza vaccine in transplant recipients. She is the protocol chair for two NIH-funded pediatric transplant studies in the Clinical Trials in Organ Transplantation in Pediatrics (CTOT-C) entitled "Viral Triggers of Alloimmunity and Autoimmunity in Pediatric Lung Transplantation (CTOTC-03)" and "Perceived Barriers to Patient Adherence after Pediatric Solid Organ Transplantation (CTOTC-05)" with principal investigator Stuart Sweet at Washington University.

Dr. Danziger-Isakov is a member of several international organizations, with guest lectureships throughout the North America and Europe. She has been recognized with the Clinical Science Career Development Award from the American Society of Transplantation in 2012, has been elected as co-editor for the American Society of Transplantation’s 3rd Edition of the Infectious Diseases Guidelines, and served as Infectious Disease Council Chair for the International Society of Heart and Lung Transplantation.

Education and Training

MD: Case Western Reserve University, Cleveland, OH, 1997.

MPH: Saint Louis University, St. Louis, MO, 2004.

Residency: Pediatrics, Cleveland Clinic Foundation, Cleveland, OH, 1997-2000.

Fellowship: Pediatric Infectious Diseases, St. Louis Children’s Hospital, Washington Univeristy, St. Louis, MO, 2000-2003.

Certification: Pediatrics, 2000; Pediatric Infectious Diseases, 2003.

Publications

View PubMed Publications

Danziger-Isakov LA, Sweet S, DelaMorena M, Mendeloff E, Huddleston CB, DeBaun MR. Epidemiology of bloodstream infections in the first year after pediatric lung transplantation. The Pediatr Infectious Disease Journal. 2005; 24(4):324-330.

Spivey JF, Singleton D, Sweet S, Storch GA, Hayashi RJ, Huddleston CB, Danziger-Isakov LA. Prolonged Prophylaxis Against Cytomegalovirus (CMV) With Ganciclovir To Diminish CMV Viremia in Pediatric Lung Transplant Recipients: A Phase II Pilot Study. Pediatric Transplantation. 2007;11(3):312-8.

Danziger-Isakov LA, Worley S, Arrigain S,Aurora P, Ballmann M, Boyer D, Conrad C, Eichler I, Elidemir O, Goldfarb S, Mallory GB, Michaels MG, Michelson P, Mogayzel PJ, Parakininkas D, Solomon M, Visner G, Sweet S, Faro A. Increased Mortality after pulmonary fungal infection within the first year after pediatric lung transplantation. J Heart Lung Transplant. 2008; 27(6): 655-661.

Danziger-Isakov LA, Worley S, Michaels MG, Arrigain S, Aurora P, Ballmann M, Boyer D, Conrad C, Eichler I, Elidemir O, Goldfarb S, Mallory GB, Mogayzel PJ, Parakininkas D, Solomon M, Visner G, Sweet S, Faro A. The risk, prevention & outcome of cytomegalovirus after pediatric lung transplantation. Transplantation. 2009 May 27;87(10):1541-8.

Liu M, Worley S, Arrigain S, Aurora P, Ballmann M, Boyer D, Conrad C, Eichler I, Elidemir O, Goldfarb S, Mallory GB, Michelson P, Mogayzel PJ, Parakinikas D, Visner G, Sweet S, Faro A, Michaels M, Danziger-Isakov LA. Respiratory Viral Infections within one year after Pediatric Lung Transplant. Transpl Infect Dis. 2009 Aug;11(4):304-12.

Ranganathan K, Worley S, Michaels MG, Arrigan S, Aurora P, Ballmann M, Boyer D, Conrad C, Eichler I, Elidemir O, Goldfarb S, Mallory GB Jr, Mogayzel PJ, Parakininkas D, Solomon M, Visner G, Sweet SC, Faro A, Danziger-Isakov L. Cytomegalovirus immunoglobulin decreases the risk of cytomegalovirus infection but not disease after pediatric lung transplantation. J Heart Lung Transplant. 2009 Oct;28(10):1050-6.

Danziger-Isakov LA, Cherkassky L, Siegel H, McManamon M, Kramer K, Budev M, Sawinski D, Augustine JJ, Hricik DE, Fairchild R, Heeger PS, Poggio ED. Effects of influenza immunization on humoral and cellular alloreactivity in humans. Transplantation, 2010 Apr 15;89(7):838-44.

Cherkassky L, Lanning M, Lalli PN, Czerr J, Siegel H, Danziger-Isakov L, Srinivas T, Valujskikh A, Shoskes DA, Baldwin W, Fairchild RL, Poggio ED. Evaluation of Alloreactivity in Kidney Transplant Recipients Treated with Antithymocyte Globulin Versus IL-2 Receptor Blocker. Am J Transplant. 2011 Jul;11(7):1388-1396.

Moses J, Alkhouri N, Shannon A, Raig K, Lopez R, Danziger-Isakov L, Feldstein AE, Zein NN, Wyllie R, Carter-Kent C. Hepatitis B Immunity and Response to Booster Vaccination in Children With Inflammatory Bowel Disease Treated With Infliximab. Am J Gastroenterol. 2011 Aug 30.

Li L, Avery R, Budev M, Mossad S, Danziger-Isakov L. Oral versus inhaled ribavirin therapy for respiratory syncytial virus infection after lung transplantation. J Heart Lung Transplant. 2012 Aug;31(8):839-44.

Grants

Viral triggers of alloimmunity and autoimmunity in pediatric lung transplantation. Co-Investigator. Protocol Chair, Steering Committee, NIH/NIAID, March 2008-Feb 2013. 1U01AI77810-01.

Viral Triggers of Alloimmunity and Autoimmunity in Pediatric Lung Transplantation (ARRA). Co-Investigator. Protocol Chair, Steering Committee, NIH/NIAID, Sep 2009-Aug 2013. 1 U01 AI077810-02S1.

Viral Triggers of Alloimmunity and Autoimmunity in Pediatric Lung Transplantation (ARRA), Perceived Barriers to Patient Adherence after Pediatric Solid Organ Transplantation. Co-Investigator. Protocol Chair, Steering Committee, NIH/NIAID, Sep 2010-Aug 2013. U01 AI077810-03S1.

Robert W. Frenck, Jr., MD
Director, Clinical Medicine

513-803-3164

robert.frenck@cchmc.org

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Robert W. Frenck, Jr., MD.

Director, Clinical Medicine

Professor, UC Department of Pediatrics

Phone: 513-803-3164

Fax: 513-636-3959

Email: robert.frenck@cchmc.org

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Specialties

Vaccine research; enteric diseases; travel medicine

Biography

Robert W. Frenck, Jr, MD, received his undergraduate degree from the University of California at San Diego in 1977 followed by his doctor of medicine degree from the University of Texas Health Science Center at Houston in 1981. He trained at the National Naval Medical Center in Bethesda, Maryland completing his pediatric residency in 1984. After 3 years as a general pediatrician at the US Naval Hospital, Japan, he entered pediatric infectious disease fellowship training at the University of Texas Health Science Center at Houston which he completed in 1990. Dr. Frenck is board-certified in both pediatrics and infectious diseases.

Dr. Frenck's research interests include therapeutic and vaccine clinical trials with special interest in enteric diseases. After completing a 25 year career in the Navy, Dr. Frenck joined the UCLA Center for Vaccine Research in 2004 and served until 2006 as Director of the Center and a Professor of Pediatrics at UCLA School of Medicine. Dr. Frenck has been active in the American Academy of Pediatrics and currently serves on the Red Book Committee. He is an acknowledged authority in infectious diseases and has authored over 60 articles and book chapters on various aspects of this subject.

Education and Training

BA: University of California at San Diego, San Diego, CA, 1977.

MD: University of Texas Medical School at Houston, Houston, TX, 1981.

Internship and Residency: US Naval Hospital, Bethesda, MD, 1981 - 1984.

Fellowship: Pediatric Infectious Diseases, University of Texas Medical School at Houston, Houston, TX, 1987 - 1990.

Publications

View PubMed Publications

Riddle MS, Rockabrand DM, Schlett C, Monteville MR, Frenck RW, Romine M, Ahmed SF, Sanders JW. A prospective study of acute diarrhea in a cohort of United States military personnel on deployment to the multinational force and observers, Sinai, Egypt. Am J Trop Med Hyg. 2011 Jan;84(1):59-64.

Schlaudecker EP, Frenck RW Jr. Adolescent pneumonia. Adolesc Med State Art Rev. 2010 Aug;21(2):202-19, vii-viii. Review.

Braverman PK, Frenck RW Jr, Holland-Hall C. Infectious diseases and immunizations. Preface. Adolesc Med State Art Rev. 2010 Aug;21(2):xii. No abstract available.

Matson DO, Abdel-Messih IA, Schlett CD, Bok K, Wienkopff T, Wierzba TF, Sanders JW, Frenck RW Jr. Rotavirus genotypes among hospitalized children in Egypt, 2000-2002.J Infect Dis. 2010 Sep 1;202 Suppl:S263-5.

Frenck RW Jr, Seward JF. Varicella vaccine safety and immunogenicity in patients with juvenile rheumatic diseases receiving methotrexate and corticosteroids. Arthritis Care Res (Hoboken). 2010 Jul;62(7):903-6. No abstract available.

Mansour AM, Nakhla II, Sultan YA, Frenck RW Jr. Brucella meningitis: first reported case in Egypt. East Mediterr Health J. 2009 Jul-Aug;15(4):1040-4. No abstract available.

Porter CK, Riddle MS, Tribble DR, Putnam SD, Rockabrand DM, Frenck RW, Rozmajzl P, Kilbane E, Fox A, Ruck R, Lim M, Johnston J, Murphy E, Sanders JW. The epidemiology of travelers' diarrhea in Incirlik, Turkey: a region with a predominance of heat-stabile toxin producing enterotoxigenic Escherichia coli. Diagn Microbiol Infect Dis. 2010 Mar;66(3):241-7.

Melmed GY, Agarwal N, Frenck RW, Ippoliti AF, Ibanez P, Papadakis KA, Simpson P, Barolet-Garcia C, Ward J, Targan SR, Vasiliauskas EA. Immunosuppression impairs response to pneumococcal polysaccharide vaccination in patients with inflammatory bowel disease. Am J Gastroenterol. 2010 Jan;105(1):148-54.

Frenck RW, Fathy H, Sherif M, Mohran Z, El Mohammedy, Francis HW, Rockabrand D, Mounir BI, Rozmajzl P, Frierson H. Sensitivity and Specificity of Various Tests for the Diagnosis of H. pylori in Egyptian Children. Pediatrics; 2006;118:e1195-1202.

Monteville MR, Riddle MS, Baht U, Putnam SD, Frenck RW, Brooks K, Moustafa M, Bland J, Sanders JW. Incidence, Etiology and Impact of Diarrhea Among Deployed US Military Personnel in Support of Operation Iraqi Freedom and Operation Enduring Freedom. Am Soc Trop Med Hyg; 2006;75:762-7.

Joseph E. Qualls, PhD

513-636-9102

joseph.qualls@cchmc.org

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Joseph E. Qualls, PhD

Assistant Professor, UC Department of Pediatrics

Phone: 513-636-9102

Email: joseph.qualls@cchmc.org

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Specialties

Immunology; innate immunity; macrophage biology; amino acid metabolism; intracellular pathogenesis

Biography

Dr. Qualls completed his undergraduate work in 2002, receiving his BA summa cum laude in Biology from Thomas More College in Crestview Hills, Ky. He then joined the laboratory of Don Cohen, PhD, in the Department of Microbiology, Immunology and Molecular Genetics at the University of Kentucky, where he studied the role of macrophages and dendritic cells during the development of inflammatory bowel disease. After defending his thesis and receiving his PhD in 2007, Dr. Qualls began his postdoctoral training with Peter Murray, PhD, in the Department of Infectious Diseases and Immunology at St. Jude Children’s Research Hospital in Memphis, Tenn., where his research helped to define the functional plasticity of macrophages in response to infection and cancer. During his postdoctoral training, Dr. Qualls received a Ruth L. Kirschstein National Research Service Award and actively participated as vice chair of Mentoring Activities within the Postdoctoral Association Council and as a member of the Education Programs Committee.

Dr. Qualls’ long-term goals are to understand the interplay between nutrition, metabolism and immune regulation during anti-pathogen defense. He has focused on how macrophages use the amino acid, L-arginine, to combat intracellular pathogens. As a starting point to appreciate broader principles of immunity and metabolism he established a map of L-arginine metabolism at the transcriptomic and metabolomic levels. His laboratory now uses this map to dissect how L-arginine generates anti-microbial effectors, how this pathway is regulated, and how microbes can hijack the pathway. His current research has two complementary tracks that retain initial focus on L-arginine metabolism in macrophages, but will eventually broaden into larger issues concerning metabolism in immunity.

Current research: Many groups have shown that T cell function is inhibited via byproducts of L-arginine metabolism or when extracellular L-arginine becomes limiting. In one project, the laboratory is focused on characterizing the in vivo function of L-arginine utilization by macrophages during mycobacterial infection, and how this affects anti-pathogen T cell function. In parallel, the laboratory is addressing the provocative role of L-arginine biosynthesis from L-citrulline during intracellular infection, and how this mechanism is regulated at the cellular level. While greatly unexplored, this pathway of amino acid recycling is vital as mice deficient in L-arginine biosynthesis, compared to normal mice, lack efficient control of both M. bovis BCG and M. tuberculosis infection.

Education and Training

BA: Thomas More College, Crestview Hills, KY, 2002.

PhD: University of Kentucky, Lexington, KY, 2007.

Postdoctoral Fellowship: St. Jude Children’s Research Hospital, Memphis, TN, 2012.

Publications

View PubMed Publications

Qualls JE, Subramanian C, Smith AM, Balouzian L, DeFreitas AA, Shirey KA, Reutterer B, Kernbauer E, Stockinger S, Decker T, Miyairi I, Vogel SN, Rock CO, Murray PJ. Sustained generation of nitric oxide and control of mycobacterial infection requires argininosuccinate synthase 1. Cell Host & Microbe. 2012 Sept 13;12(3):313-23.

Smith AM, Qualls JE, O’Brien K, Balouzian L, Johnson PF, Schultz-Cherry S, Smale ST, Murray PJ. A Distal Enhancer in Il12b is the Target of Transcriptional Repression by the Stat3 Pathway and Requires the B-Zip Protein NFIL-3. Journal of Biological Chemistry. 2011 Jul 1;286(26):23582-90.

Qualls JE, Murray PJ. Tumor Macrophages: Protective and Pathogenic Roles in Cancer Development. Current Topics in Developmental Biology. 2011;94:309-28.

Qualls JE, Neale G, Smith AM, Koo MS, DeFreitas AA, Zhang H, Kaplan G, Watowich SS, Murray PJ. Arginine usage in mycobacteria-infected macrophages depends on autocrine-paracrine cytokine signaling. Science Signaling. 2010 Aug 17;3(135):ra62.

Qualls JE, Murray PJ. A double agent in cancer: stopping macrophages wounds tumors. Nature Medicine. 2010 Aug;16(8):863-4.

Qualls JE, Tuna H, Kaplan AM, Cohen DA. Dendritic Cell-Mediated Suppression of Dextran Sodium Sulfate-Induced Colitis in Mice. Inflammatory Bowel Disease.

El Kasmi KC, Qualls JE (co-primary author), Pesce JT, Smith AM, Thompson RW, Henao-Tamayo M, Basaraba RJ, König T, Schleicher U, Koo M, Kaplan G, Fitzgerald KA, Tuomanen EI, Orne IM, Kanneganti T, Bogdan C, Wynn TA, and Murray PJ. TLR-induced Arginase 1 thwarts effective immunity against intracellular pathogens. Nature Immunology. 2008 Dec;9(12):1399-406.

Moreira LO, Smith AM, DeFreitas AA, Qualls JE, El Kasmi KC, Murray PJ. Modulation of adaptive immunity by different adjuvant-antigen combinations in mice lacking Nod2. Vaccine. 2008 Oct 29;26(46):5808-13.

Qualls JE, Kaplan AM, van Rooijen N, Cohen DA. Suppression of Experimental Colitis by Intestinal Mononuclear Phagocytes. Journal of Leukocyte Biology. 2006 Oct;80(4):802-15.

Burnett SH, Beus BJ, Avdiushko R, Qualls J, Kaplan AM, Cohen DA. Development of Peritoneal Adhesions in Macrophage Depleted Mice. Journal of Surgical Research. 2006 Apr;131(2):296-301.

Grants

Consequences of amino acid limitation on immune function. Principle Investigator. Cincinnati Children’s TAPS Program, Trustee Award. Jan. 2013 – Dec. 2014.

Elizabeth P. Schlaudecker, MD, MPH

513-803-5187

elizabeth.schlaudecker@cchmc.org

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Elizabeth P. Schlaudecker, MD, MPH

Assistant Professor, UC Department of Pediatrics

Phone: 513-803-5187

Email: elizabeth.schlaudecker@cchmc.org

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Specialties

Global health; influenza; prevention of infant infection with maternal immunization

Biography

Elizabeth P. Schlaudecker, MD, MPH, is a faculty member in the Division of Infectious Diseases and the Global Health Center. Dr. Schlaudecker received her medical degree and master's in public health from the University of Cincinnati and completed a pediatrics residency and chief residency at Cincinnati Children's.

Dr. Schlaudecker was awarded a Fogarty International Clinical Research Fellowship from the National Institutes of Health in 2009, and she investigated the etiology and seasonality of viral respiratory disease in Honduran children under the age of five. She was awarded the Pediatric Infectious Diseases Society Blue Ribbon Research award in 2011 for similar work in Bangladesh. After joining the faculty of Cincinnati Children's in 2011, she continued her influenza research with a Procter Scholars award. Dr. Schlaudecker has traveled to Honduras, the Dominican Republic, Costa Rica, Ecuador, Kenya, South Africa, and Cameroon as part of her clinical and research training.

Education and Training

MD: University of Cincinnati, Cincinnati, OH, 2003.

Residency: Pediatrics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2006.

Chief Residency: Pediatrics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2007.

Fellowship: Infectious Diseases, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2011.

MPH: Public Health, University of Cincinnati, Cincinnati, OH, 2011.

Certification: Pediatrics, 2006.

Publications

View PubMed Publications

Schlaudecker EP, Steinhoff MC, Moore SR. Interactions of diarrhea, pneumonia, and malnutrition in childhood: recent evidence from developing countries. Curr Opin Infect Dis. 2011 Jul 2. Epub ahead of print.

Schlaudecker EP and Steinhoff MC. Helping mothers prevent influenza illness in their infants. Pediatrics. 2010;126(5):1008-1011.

Schlaudecker EP and Frenck RW. Adolescent pneumonia. Adolesc Med State Art Rev. 2010;21:202-219.

Grants

Comparison of Immunological Responses to Influenza Infection and Immunization in Pregnant and Non-Pregnant Women. Principal Investigator. Cincinnati Children’s Hospital Medical Center. 2011 - 2013.

Samir S. Shah, MD, MSCE
Director, Hospital Medicine

513-636-6222

samir.shah@cchmc.org

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Samir S. Shah, MD, MSCE

Director, Hospital Medicine

Research Director, Hospital Medicine

Associate Professor, UC Department of Pediatrics

Phone: 513-636-6222

Email: samir.shah@cchmc.org

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Specialties

Pediatric infectious diseases; pediatric hospital medicine; community-acquired pneumonia; bacterial meningitis; observational study designs; administrative data sources

Biography

Samir S. Shah, MD, MSCE, is a pediatric infectious diseases and pediatric hospital medicine physician whose research focuses on improving the efficiency and quality of care of children hospitalized with common, serious infections such as pneumonia and meningitis. Ongoing projects include studying the comparative effectiveness of different antibiotics in the treatment of community-acquired pneumonia and developing novel databases to conduct comparative effectiveness research.

Dr. Shah is currently the associate chair of the National Pneumonia Guidelines Committee, jointly sponsored by the Infectious Diseases Society of America and the Pediatric Infectious Diseases Society. He is also an executive council member of the Pediatric Research in Inpatient Settings (PRIS) Network.

Dr. Shah is an associate editor of the Journal of Hospital Medicine, the official journal of the Society of Hospital Medicine. He also serves on the editorial boards of Archives of Pediatrics & Adolescent Medicine and Infection Control & Hospital Epidemiology. In addition, he is editor or co-editor of 7 books in the fields of Pediatrics and Infectious Diseases including The Philadelphia Guide: Inpatient Pediatrics (Lippincott Williams & Wilkins), and Pediatric Practice: Infectious Diseases (McGraw-Hill Medical), an infectious diseases textbook written for the pediatric generalist.

Dr. Shah has received several prestigious research awards, including the Society of Hospital Medicine Excellence in Research Award, the Pediatric Infectious Diseases Society Burtis Burr Breese Award, and the Pediatric Infectious Diseases Society Young Investigator Award.

Education and Training

BA: University of Pennsylvania, Philadelphia, PA, 1993.

MD: Yale University School of Medicine, New Haven, CT, 1998.

Residency: Pediatrics, The Children’s Hospital of Philadelphia, Philadelphia, PA, 2001.

Fellowship: Pediatric Infectious Diseases, The Children’s Hospital of Philadelphia, Philadelphia, PA, 2005; Academic General Pediatrics, The Children’s Hospital of Philadelphia, Philadelphia, PA, 2005.

MSCE: University of Pennsylvania School of Medicine, Philadelphia, PA, 2007.

Certification: Pediatrics, 2001, 2008; Pediatric Infectious Diseases, 2005.

Publications

View PubMed Publications

Gollomp K, Rankin SC, White C, Mattei P, Harris MC, Kilpatrick LE, Sheffler-Collins S, McGowan KL, Shah SS. Broad-range polymerase chain reaction in the microbiologic diagnosis of complicated pneumonia. J Hosp Med. 2011.

Williams DJ, Hall M, Brogan TV, Farris RWD, Myers AL, Newland JG, Shah SS. Influenza co-infection and outcomes in children with complicated pneumonia. Arch Pediatr Adolesc Med. 2011;165:506-512.

Shah SS, Hall M, Newland JG, Brogan TV, Farris RWD, Williams DJ, Larsen G, Fine BR, Levin JE, Wagener JS, Conway PH, Myers AL. Comparative effectiveness of pleural drainage procedures for the treatment of complicated pneumonia in childhood. J Hosp Med. 2011;6:256-263.

Kronman MP, Hersh AL, Feng R, Huang YS, Lee GE, Shah SS. National trends in ambulatory visit rates and antibiotic prescribing for children with pneumonia, 1994-2007. Pediatrics. 2011;127:411-418.

Weiss AK, Hall M, Lee GE, Kronman MP, Sheffler-Collins S, Shah SS. Adjunct corticosteroids in children hospitalized with community-acquired pneumonia. Pediatrics. 2011;127:e255-e263.

Pasquali SK, Jacobs JP, Shook GJ, O’Brien SM, Hall M, Jacobs ML, Welke KF, Gaynor JW, Peterson ED, Shah SS, Li JS. Linking clinical registry data with administrative data using indirect identifiers: Implementation and validation in the congenital heart surgery population. Am Heart J. 2010;160:1099-1104.

Pasquali SK, Hall M, Li JS, Peterson ED, Jaggers J, Lodge AJ, Marino BS, Goodman DM, Shah SS. Corticosteroids and outcome in children undergoing congenital heart surgery. Circulation. 2010;122:2123-2130.

Lee GE, Lorch SA, Sheffler-Collins S, Kronman MP, Shah SS. National hospitalization trends for pediatric pneumonia and associated complications. Pediatrics. 2010;126:204-213.

Feudtner C, Pati S, Goodman DM, Kahn MG, Sharma V, Hutto JH, Levin JE, Slonim AD, Hall M, Shah SS. Do systems of healthcare affect the likelihood of pediatric hospital readmission? A nationwide multi-state study. J Pediatr. 2010;157:98-102.

Fieldston ES, Hall M, Sills MR, Slonim AD, Myers AL, Cannon C, Pati S, Shah SS. Children’s hospitals do not acutely respond to high occupancy. Pediatrics. 2010;125:974-981.

Grants

Predicting adverse outcomes in childhood pneumonia. Principal Investigator. Robert Wood Johnson Foundation. Jul 2008 - Dec 2011.

PHIS+: augmenting the pediatric health information system with clinical data. Site Principal Investigator. Agency for Healthcare Research and Quality. Sep 2010 - Sep 2013. #R01 HS019862
.
Pediatric research in inpatient settings: research prioritization for pediatric hospital medicine. Site Principal Investigator. Child Health Corporation of America. Mar 2010 - Feb 2013.

Predicting adverse outcomes in children with community-acquired pneumonia. Principal Investigator. National Institute of Allergy and Infectious Diseases. Feb 2008 - January 2013. #K01 AI73729.

Mary Allen Staat, MD, MPH
Director, International Adoption Center

513-636-2877

mary.staat@cchmc.org

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Mary Staat, MD, MPH

Director, International Adoption Center

Professor, UC Department of Pediatrics

Phone: 513-636-2877

Fax: 513-636-6936

Email: mary.staat@cchmc.org

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Specialties

Clinical Interests

Helicobacter pylori, rotavirus epidemiology, travel medicine and infectious diseases of international adoptees

Research Interests

Epidemiology of enteric infections and surveillance of infectious diseases

Biography

Mary Allen Staat, MD, MPH, is director of the International Adoption Center and a member of the Infectious Disease Division at Cincinnati Children's Hospital Medical Center.

Dr. Staat is a board-certified pediatrician and is also board-certified in Infectious Disease and Preventive Medicine. She is an associate professor of Pediatrics at the University of Cincinnati and a faculty member of the Cincinnati Children's Hospital Research Foundation.

Education and Training

MD: University of Kentucky, Lexington, Ky., 1986.

MPH: Johns Hopkins University, Baltimore, Md., 1991.

Residency: Pediatrics, Baylor College of Medicine, Houston, Texas, 1986-1989; Preventive Medicine, Johns Hopkins University, Baltimore, Md., 1990-1994.

Fellowship: Infectious Diseases, Baylor College of Medicine, Houston, Texas, 1989-1990; Epidemiology, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Rockville, Md., 1990-1993.

Certification: Pediatrics, 1989; Preventive Medicine, 1996; Pediatric Infectious Diseases, 1999.

Publications

View PubMed Publications

Staat MA, Rice MA, Donauer S, Payne DC, Bresee JS, Mast TC, Curns AT, Cortese MM, Connelly B, McNeal M, Ward RL, Bernstein DI, Parashar UD, Salisbury S. Estimating the rotavirus hospitalization disease burden and trends, using capture-recapture methods. Pediatr Infect Dis J. 2010 Dec;29(12):1083-6.

Abdulla RY, Rice MA, Donauer S, Hicks KR, Poore D, Staat MA. Hepatitis A in internationally adopted children: screening for acute and previous infections. Pediatrics. 2010 Nov;126(5):e1039-44.

Staat MA, Stadler LP, Donauer S, Trehan I, Rice M, Salisbury S. Serologic testing to verify the immune status of internationally adopted children against vaccine preventable diseases. Vaccine. 2010 Nov 23;28(50):7947-55.

Fairbrother G, Cassedy A, Ortega-Sanchez IR, Szilagyi PG, Edwards KM, Molinari NA, Donauer S, Henderson D, Ambrose S, Kent D, Poehling K, Weinberg GA, Griffin MR, Hall CB, Finelli L, Bridges C, Staat MA; New Vaccine Surveillance Network (NVSN). High costs of influenza: Direct medical costs of influenza disease in young children. Vaccine. 2010 Jul 12;28(31):4913-9.

Mast TC, Walter EB, Bulotsky M, Khawaja SS, DiStefano DJ, Sandquist MK, Straus WL, Staat MA. Burden of childhood rotavirus disease on health systems in the United States. Pediatr Infect Dis J. 2010 Feb;29(2):e19-25.

Payne DC, Szilagyi PG, Staat MA, Edwards KM, Gentsch JR, Weinberg GA, Hall CB, Curns AT, Clayton H, Griffin MR, Fairbrother G, Parashar UD. Secular variation in United States rotavirus disease rates and serotypes: implications for assessing the rotavirus vaccination program. Pediatr Infect Dis J. 2009 Nov;28(11):948-53.

Dickey M, Jamison L, Michaud L, Care M, Bernstein DI, Staat MA. Rotavirus meningoencephalitis in a previously healthy child and a review of the literature. Pediatr Infect Dis J. 2009 Apr;28(4):318-21.

Linam WM, Margolis PA, Staat MA, Britto MT, Hornung R, Cassedy A, Connelly BL. Risk factors associated with surgical site infection after pediatric posterior spinal fusion procedure. Infect Control Hosp Epidemiol. 2009 Feb;30(2):109-16.

Stadler LP, Mezoff AG, Staat MA. Hepatitis B virus screening for internationally adopted children. Pediatrics. 2008 Dec;122(6):1223-8.

Yee EL, Staat MA, Azimi P, Bernstein DI, Ward RL, Schubert C, Matson DO, Turcios-Ruiz RM, Parashar U, Widdowson MA, Glass RI. Burden of rotavirus disease among children visiting pediatric emergency departments in Cincinnati, Ohio, and Oakland, California, in 1999-2000. Pediatrics. 2008 Nov;122(5):971-7.

Sing Sing Way, MD, PhD
Pauline and Lawson Reed Chair, Division of Infectious Diseases

513-636-7603

singsing.way@cchmc.org

High Res

Sing Sing Way, MD, PhD

Pauline and Lawson Reed Chair, Division of Infectious Diseases

Associate Professor, UC Department of Pediatrics

Phone: 513-636-7603

Email: singsing.way@cchmc.org

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Specialties

Infectious diseases; prenatal infection; immunology

Biography

Dr. Way is an infectious disease physician-scientist. He cares for infants and children with infection related illness, and provides consultation in the diagnosis and prevention diseases caused by communicable agents. Dr. Way supervises an active basic research laboratory that uses basic immunological approaches to investigate ways to boost host defense and protection against infection. Ongoing projects investigate the immune basis responsible for enhanced susceptibility to infection during pregnancy, the immune pathogenesis of pregnancy complications that occur with maternal infection, and the basic signals required for stimulating immune cell activation.

Dr. Way trained in the combined MD/PhD program at the Albert Einstein College of Medicine, pediatric residency at the University of California San Francisco, and infectious disease fellowship at the University of Washington. During fellowship training, Dr. Way began investigating the basic immunology and immune pathogenesis of infectious diseases relevant to human, and in particular, infant and child health.

Dr. Way’s research has been supported by the National Institutes of Health since 2006. Dr. Way’s research has been described in many publications in numerous prestigious scientific journals including Nature, Cell Host & Microbe, PLoS Pathogens, and The Journal of Immunology. The past and ongoing work has also been recognized by numerous prestigious awards including the Infectious Diseases Society of America Wyeth Young Investigator Award, a Basil O’ Conner Award from the March of Dimes Foundation, and the Investigator in Pathogenesis of Infectious Diseases award from the Burroughs Wellcome Fund.

Education and Training

MD PhD: Albert Einstein College of Medicine, Bronx, NY, 1999.

Residency: University of California San Francisco, San Francisco, CA, 2001.

Fellowship: University of Washington, Seattle, WA, 2004.

Publications

View PubMed Publications

Rowe JH, Ertelt JM, Xin L, Way SS. Pregnancy imprints regulatory memory that sustains anergy to fetal antigen. Nature. 490: 102-106. 2012.

Rowe JH, Ertelt JM, Xin L, Way SS. Listeria monocytogenes cytoplasmic entry induces fetal wastage by disrupting maternal Foxp3+ regulatory T cell-sustained fetal tolerance. PLoS Pathog. 8: e1002873. 2012.

Rowe JH, Ertelt JM, Way SS. Innate IFN-g is essential for Programmed death ligand-1-mediated T cell stimulation following Listeria monocytogenes infection. J Immunol. 189: 876-84. 2012.

Rowe JH, Ertelt JM, Way SS. Foxp3+ regulatory T cells, immune stimulation, and host defense against infection. Immunology. 136:1-10. 2011.

Ertelt JM, Johanns TM, Mysz MA, Nanton MR, Rowe JH, Aguilera MN, Way SS. Selective culling of high avidity antigen-specific CD4+ T cells after virulent Salmonella infection. Immunology. 134: 487-97. 2011.

Ertelt JM, Rowe JH, Mysz MA, Singh C, Roychowdhury M, Aguilera MN, Way SS. Foxp3+ regulatory T cells impede the priming of protective CD8+ T cells. J Immunol. 187: 2569-77. 2011.

Rowe JH, Ertelt JM, Aguilera MN, Farrar MA, Way SS. Foxp3+ regulatory T cell expansion required for sustaining pregnancy compromises host defense against prenatal bacterial pathogens. Cell Host Microbe. 10:54-64. 2011.

Johanns TM, Law CY, Kalekar LA, O’Donnell H, Ertelt JM, Rowe JH, Way SS. Early eradication of persistent Salmonella infection primes antibody-mediated protective immunity to recurrent infection. Microbes Infect. 13: 322-330. 2011.

Han JY, Hanson DC, Way SS. Herpes Zoster and meningitis due to reactivation of varicella vaccine virus in a immunocompetent child. Pediatr Infect Dis J. 30:266-268. 2011.

Ertelt JM, Johanns TM, Rowe JH, Way SS. IL-21-independent pathogen-specific CD8+ T cell expansion, and IL-21-dependnent suppression of CD4+ T cell IL-17 production. Immunology. 131: 183-191. 2010.

Grants

Maternal regulatory T cells control the immune pathogenesis of prenatal infection. Principal Investigator in the Pathogenesis of Infectious Disease. Burroughs Wellcome Fund. 2012-2017.

The immune pathogenesis of prenatal Listeria monocytogenes infection. Principle Investigator. National Institute of Allergy and Infectious Diseases (NIAID). 2012-2017. R01-AI100934.

Regulatory T cells dictate the immunity during persistent Salmonella infection. Principle Investigator. National Institute of Allergy and Infectious Diseases (NIAID). 2010-2015. R01-AI087830.

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Margaret K. Hostetter, MD

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Rebecca C. Brady, MD

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Beverly L. Connelly, MD

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Lara A. Danziger-Isakov, MD, MPH

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Robert W. Frenck, Jr., MD.

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Joseph E. Qualls, PhD

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Elizabeth P. Schlaudecker, MD, MPH

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Samir S. Shah, MD, MSCE

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Mary Staat, MD, MPH

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Sing Sing Way, MD, PhD

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