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Division of Infectious Diseases is home to specialists with a wide variety of backgrounds and areas of focus. As a team, this diversity makes us better prepared to care for your child’s unique needs. Learn more about our faculty and staff.
Robert W. Frenck Jr., MD Interim Director, Division of Infectious Diseases
Interim Director, Division of Infectious Diseases
Medical Director, Division of Infectious Diseases
Professor, UC Department of Pediatrics
Vaccine research; enteric diseases; travel medicine
Enteric diseases; vaccinology
Robert W. Frenck Jr., MD, received his undergraduate degree from the University of California at San Diego in 1977 followed by his doctor of medicine degree from the University of Texas Health Science Center at Houston in 1981. He trained at the National Naval Medical Center in Bethesda, Maryland, completing his pediatric residency in 1984. After three years as a general pediatrician at the US Naval Hospital, Japan, he entered pediatric infectious disease fellowship training at the University of Texas Health Science Center at Houston, which he completed in 1990. Dr. Frenck is board-certified in both pediatrics and infectious diseases.
Dr. Frenck's research interests include therapeutic and vaccine clinical trials with special interest in enteric diseases. After completing a 25-year career in the Navy, Dr. Frenck joined the UCLA Center for Vaccine Research in 2004 and served until 2006 as director of the Center and a Professor of Pediatrics at UCLA School of Medicine. Dr. Frenck has been active in the American Academy of Pediatrics and currently serves on the Red Book Committee. He is an acknowledged authority in infectious diseases and has authored over 60 articles and book chapters on various aspects of this subject.
Riddle MS, Rockabrand DM, Schlett C, Monteville MR, Frenck RW, Romine M, Ahmed SF, Sanders JW. A prospective study of acute diarrhea in a cohort of United States military personnel on deployment to the multinational force and observers, Sinai, Egypt. Am J Trop Med Hyg. 2011 Jan;84(1):59-64.
Schlaudecker EP, Frenck RW Jr. Adolescent pneumonia. Adolesc Med State Art Rev. 2010 Aug;21(2):202-19, vii-viii. Review.
Braverman PK, Frenck RW Jr, Holland-Hall C. Infectious diseases and immunizations. Preface. Adolesc Med State Art Rev. 2010 Aug;21(2):xii. No abstract available.
Matson DO, Abdel-Messih IA, Schlett CD, Bok K, Wienkopff T, Wierzba TF, Sanders JW, Frenck RW Jr. Rotavirus genotypes among hospitalized children in Egypt, 2000-2002. J Infect Dis. 2010 Sep 1;202 Suppl:S263-5.
Frenck RW Jr, Seward JF. Varicella vaccine safety and immunogenicity in patients with juvenile rheumatic diseases receiving methotrexate and corticosteroids. Arthritis Care Res (Hoboken). 2010 Jul;62(7):903-6. No abstract available.
Mansour AM, Nakhla II, Sultan YA, Frenck RW Jr. Brucella meningitis: first reported case in Egypt. East Mediterr Health J. 2009 Jul-Aug;15(4):1040-4. No abstract available.
Porter CK, Riddle MS, Tribble DR, Putnam SD, Rockabrand DM, Frenck RW, Rozmajzl P, Kilbane E, Fox A, Ruck R, Lim M, Johnston J, Murphy E, Sanders JW. The epidemiology of travelers' diarrhea in Incirlik, Turkey: a region with a predominance of heat-stabile toxin producing enterotoxigenic Escherichia coli. Diagn Microbiol Infect Dis. 2010 Mar;66(3):241-7.
Melmed GY, Agarwal N, Frenck RW, Ippoliti AF, Ibanez P, Papadakis KA, Simpson P, Barolet-Garcia C, Ward J, Targan SR, Vasiliauskas EA. Immunosuppression impairs response to pneumococcal polysaccharide vaccination in patients with inflammatory bowel disease. Am J Gastroenterol. 2010 Jan;105(1):148-54.
Frenck RW, Fathy H, Sherif M, Mohran Z, El Mohammedy, Francis HW, Rockabrand D, Mounir BI, Rozmajzl P, Frierson H. Sensitivity and Specificity of Various Tests for the Diagnosis of H. pylori in Egyptian Children. Pediatrics; 2006;118:e1195-1202.
Monteville MR, Riddle MS, Baht U, Putnam SD, Frenck RW, Brooks K, Moustafa M, Bland J, Sanders JW. Incidence, Etiology and Impact of Diarrhea Among Deployed US Military Personnel in Support of Operation Iraqi Freedom and Operation Enduring Freedom. Am Soc Trop Med Hyg; 2006;75:762-7.
Rebecca C. Brady, MD Director, Adult Clinical Services
Director, Adult Clinical Services
Assistant Professor, UC Department of Pediatrics
Adult and pediatric infectious disease
Cytomegalovirus and other viral infections
MD: University of Kentucky, Lexington, KY, 1988.
Residency: Internal Medicine/Pediatrics, University of Louisville, Louisville, KY.
Fellowships: Pediatric Infectious Diseases, Children's Hospital Medical Center, Cincinnati, Ohio; Adult Infectious Diseases, University of Cincinnati, Cincinnati, OH.
Certifications: Pediatrics, 1992, recertified 1999; Internal Medicine, 1993; Pediatric Infectious Diseases, 1997; Adult Infectious Diseases, 1997.
Subbramanian RA, Basha S, Shata MT, Brady RC, Bernstein DI. Pandemic and seasonal H1N1 influenza hemagglutinin-specific T cell responses elicited by seasonal influenza vaccination. Vaccine. 2010 Dec 6;28(52):8258-67. Brady RC. Influenza. Adolesc Med State Art Rev. 2010 Aug;21(2):236-50, viii. Subbramanian RA, Basha S, Brady RC, Hazenfeld S, Shata MT, Bernstein DI. Age-related changes in magnitude and diversity of cross-reactive CD4+ T-cell responses to the novel pandemic H1N1 influenza hemagglutinin. Hum Immunol. 2010 Oct;71(10):957-63. Brady RC, Treanor JJ, Atmar RL, Keitel WA, Edelman R, Chen WH, Winokur P, Belshe R, Graham IL, Noah DL, Guo K, Hill H. Safety and immunogenicity of a subvirion inactivated influenza A/H5N1 vaccine with or without aluminum hydroxide among healthy elderly adults. Vaccine. 2009 Aug 13;27(37):5091-5.
de Bruyn G, Vargas-Cortez M, Warren T, Tyring SK, Fife KH, Lalezari J, Brady RC, Shahmanesh M, Kinghorn G, Beutner KR, Patel R, Drehobl MA, Horner P, Kurtz TO, McDermott S, Wald A, Corey L. A randomized controlled trial of a replication defective (gH deletion) herpes simplex virus vaccine for the treatment of recurrent genital herpes among immunocompetent subjects. Vaccine.2006; 24:914-20.
Treanor JJ, Schiff GM, Couch RB, Cate TR, Brady RC, Hay M, Wolff M, She D, Cox MMJ. Dose-related safety and immunogenicity of a trivalent baculovirus-expressed influenza-virus hemagglutinin vaccine in elderly adults. Journal of Infectious Diseases. 2006; 193:1223-8.
Treanor JJ, Schiff GM, Hayden FG, Brady RC, Hay CM, Meyer AL, Holden-Wiltse J, Liang H, Gilbert A, Cox M. Safety and immunogenicity of a baculovirus-expressed hemagglutinin influenza vaccine: a randomized controlled trial. Journal of the American Medical Association. 2007; 297:1577-82.
Couch RC, Winokur P, Brady RC, Belshe R, Chen WH, Cate TR, Sigurdardottir B, Hoeper A, Graham IL, Edelman R, He F, Nino D, Capellan J, Ruben FL. Safety and immunogenicity of a high dosage trivalent influenza vaccine among elderly subjects. Vaccine. 2007; 25:7656-63.
Rhonda Cardin, PhD
Associate Professor, UC Department of Pediatrics
Beverly L. Connelly, MD Director, Infection Control Program
Director, Infection Control Program
MD: Medical College of Georgia, Augusta, Ga., 1979.
Residency: Pediatrics, Children's Hospital Medical Center, Cincinnati, Ohio, 1979-1982.
Fellowship: Pediatric Infectious Disease, Children's Hospital Medical Center, Cincinnati, Ohio, 1983-1986.
Certification: Pediatrics, 1984; Pediatric Infectious Diseases, 1994, recertified, 2000.
Lara A. Danziger-Isakov, MD, MPH Director, Transplant ID
Director, Transplant ID
Transplant infectious diseases
Dr. Danziger-Isakov began her research career investigating cytomegalovirus in pediatric lung transplant recipients. After completing fellowship she led an international epidemiological study of pediatric lung transplant recipients including 14 international sites from North America and Europe to publish seminal manuscripts on fungal and viral infections through the International Pediatric Lung Transplant Collaborative. While at the Cleveland Clinic she performed an innovative investigation evaluating alloreactive cellular and humoral responses to influenza vaccine in transplant recipients. She is the protocol chair for two NIH-funded pediatric transplant studies in the Clinical Trials in Organ Transplantation in Pediatrics (CTOT-C) entitled "Viral Triggers of Alloimmunity and Autoimmunity in Pediatric Lung Transplantation (CTOTC-03)" and "Perceived Barriers to Patient Adherence after Pediatric Solid Organ Transplantation (CTOTC-05)" with principal investigator Stuart Sweet at Washington University.
Dr. Danziger-Isakov is a member of several international organizations, with guest lectureships throughout the North America and Europe. She has been recognized with the Clinical Science Career Development Award from the American Society of Transplantation in 2012, has been elected as co-editor for the American Society of Transplantation’s 3rd Edition of the Infectious Diseases Guidelines, and served as Infectious Disease Council Chair for the International Society of Heart and Lung Transplantation.
MD: Case Western Reserve University, Cleveland, OH, 1997.
MPH: Saint Louis University, St. Louis, MO, 2004.
Residency: Pediatrics, Cleveland Clinic Foundation, Cleveland, OH, 1997-2000.
Fellowship: Pediatric Infectious Diseases, St. Louis Children’s Hospital, Washington Univeristy, St. Louis, MO, 2000-2003.
Certification: Pediatrics, 2000; Pediatric Infectious Diseases, 2003.
Danziger-Isakov LA, Sweet S, DelaMorena M, Mendeloff E, Huddleston CB, DeBaun MR. Epidemiology of bloodstream infections in the first year after pediatric lung transplantation. The Pediatr Infectious Disease Journal. 2005; 24(4):324-330.
Spivey JF, Singleton D, Sweet S, Storch GA, Hayashi RJ, Huddleston CB, Danziger-Isakov LA. Prolonged Prophylaxis Against Cytomegalovirus (CMV) With Ganciclovir To Diminish CMV Viremia in Pediatric Lung Transplant Recipients: A Phase II Pilot Study. Pediatric Transplantation. 2007;11(3):312-8.
Danziger-Isakov LA, Worley S, Arrigain S,Aurora P, Ballmann M, Boyer D, Conrad C, Eichler I, Elidemir O, Goldfarb S, Mallory GB, Michaels MG, Michelson P, Mogayzel PJ, Parakininkas D, Solomon M, Visner G, Sweet S, Faro A. Increased Mortality after pulmonary fungal infection within the first year after pediatric lung transplantation. J Heart Lung Transplant. 2008; 27(6): 655-661.
Danziger-Isakov LA, Worley S, Michaels MG, Arrigain S, Aurora P, Ballmann M, Boyer D, Conrad C, Eichler I, Elidemir O, Goldfarb S, Mallory GB, Mogayzel PJ, Parakininkas D, Solomon M, Visner G, Sweet S, Faro A. The risk, prevention & outcome of cytomegalovirus after pediatric lung transplantation. Transplantation. 2009 May 27;87(10):1541-8.
Liu M, Worley S, Arrigain S, Aurora P, Ballmann M, Boyer D, Conrad C, Eichler I, Elidemir O, Goldfarb S, Mallory GB, Michelson P, Mogayzel PJ, Parakininkas D, Visner G, Sweet S, Faro A, Michaels M, Danziger-Isakov LA. Respiratory Viral Infections within one year after Pediatric Lung Transplant. Transpl Infect Dis. 2009 Aug;11(4):304-12.
Ranganathan K, Worley S, Michaels MG, Arrigan S, Aurora P, Ballmann M, Boyer D, Conrad C, Eichler I, Elidemir O, Goldfarb S, Mallory GB Jr, Mogayzel PJ, Parakininkas D, Solomon M, Visner G, Sweet SC, Faro A, Danziger-Isakov L. Cytomegalovirus immunoglobulin decreases the risk of cytomegalovirus infection but not disease after pediatric lung transplantation. J Heart Lung Transplant. 2009 Oct;28(10):1050-6.
Danziger-Isakov LA, Cherkassky L, Siegel H, McManamon M, Kramer K, Budev M, Sawinski D, Augustine JJ, Hricik DE, Fairchild R, Heeger PS, Poggio ED. Effects of influenza immunization on humoral and cellular alloreactivity in humans. Transplantation, 2010 Apr 15;89(7):838-44.
Cherkassky L, Lanning M, Lalli PN, Czerr J, Siegel H, Danziger-Isakov L, Srinivas T, Valujskikh A, Shoskes DA, Baldwin W, Fairchild RL, Poggio ED. Evaluation of Alloreactivity in Kidney Transplant Recipients Treated with Antithymocyte Globulin Versus IL-2 Receptor Blocker. Am J Transplant. 2011 Jul;11(7):1388-1396.
Moses J, Alkhouri N, Shannon A, Raig K, Lopez R, Danziger-Isakov L, Feldstein AE, Zein NN, Wyllie R, Carter-Kent C. Hepatitis B Immunity and Response to Booster Vaccination in Children With Inflammatory Bowel Disease Treated With Infliximab. Am J Gastroenterol. 2011 Aug 30.
Li L, Avery R, Budev M, Mossad S, Danziger-Isakov L. Oral versus inhaled ribavirin therapy for respiratory syncytial virus infection after lung transplantation. J Heart Lung Transplant. 2012 Aug;31(8):839-44.
David M. Hartley, PhD, MPH
Infectious disease epidemiology; public health surveillance; mathematical and computer modeling
PhD: University of Maryland Baltimore County, Baltimore, MD, 1996.
MPH: George Washington University, Washington, DC, 2006.
Smith DL, Perkins TA, Reiner Jr RC, Barker CM, Niu T, Chaves LF, Ellis AM, George DB, Le Menach A, Pulliam J, Bisanzio D, Buckee C, Chiyaka C, Cummings DAT, Garcia AJ, Gatton ML, Gething PW, Hartley DM, Johnston G, Klein EY, Michael E, Lindsay SW, Lloyd AL, Pigott DM, Reisen WK, Ruktanonchai N, Singh B, Stoller J, Tatem AJ, Kitron U, Hay SI, Scott TW. Recasting the Theory of Mosquito-Borne Pathogen Transmission Dynamics and Control. Trans R Soc Trop Med Hyg. 2014 Apr;108(4):185-87.
Hartley DM. Using social media and other Internet data for public health surveillance: The importance of talking. Milbank Q. 2014 Mar;92(1):34-9.
Barboza P, Vaillant L, Le Strat Y, Hartley DM, Nelson NP, Mawudeku A, Madoff LC, Linge JP, Collier N, Brownstein JS, Astagneau P. Factors influencing performance of Internet-based biosurveillance systems used in epidemic intelligence for early detection of infectious diseases outbreaks. PLoS One. 2014 Mar 5;9(3):e90536.
Hartley DM, Nelson NP, Arthur RR, Barboza P, Collier N, Lightfoot N, Linge JP, van der Goot E, Mawudeku A, Madoff LC, Vaillant L, Walters R, Yangarber R, Mantero J, Corley CD, Brownstein JS. An overview of Internet biosurveillance. Clin Microbiol Infect. 2013 Nov;19(11):1006-13.
Barker CM, Niu T, Reisen WK, Hartley DM. Data-driven modeling to assess receptivity for Rift Valley fever virus. PLoS Negl Trop Dis. 2013 Nov 14;7(11): e2515.
Nelson NP, Brownstein J, Hartley DM. Event-based biosurveillance of respiratory disease in Mexico, 2007-2009: Connection to influenza A(H1N1)v? Euro Surveill. 2010 Jul 29;15(30).
Nelson NP, Yang L, Reilly AR, Hardin JE, Hartley DM. Event-based Internet Biosurveillance: Relation to Epidemiological Observation. Emerg Themes Epidemiol. 2012 Jun 18;9(1):4.
Hartley DM, Barker CM, Le Menach A, Niu T, Gaff HD, Reisen WK. The effects of temperature on the emergence and seasonality of West Nile virus in California. Am J Trop Med Hyg. 2012 May;86(5):884-94.
Hartley DM, Morris JG Jr, Smith DL. Epidemiological Implications of Hyperinfectivity: A critical element in the ability of V. Cholerae to cause epidemics? PloS Med. 2006 Jan;3(1):e7.
Niu T, Gaff HD, Papelis YE, Hartley DM. An epidemiological model of Rift Valley fever with spatial dynamics. Comput Math Methods Med. 2012;2012:138757.
David B. Haslam, MD Director, Antimicrobial Stewardship Program
Director, Antimicrobial Stewardship Program
Clinical Director, Division of Infectious Diseases
Pediatric infectious diseases; host-microbial interactions; innate immunity
MD: University of Calgary, Calgary, Alberta, 1987.
Rotating Internship: McGill University, Montreal, Quebec, 1988.
Residency: University of Ottawa, Ottawa, Quebec, 1991.
Fellowship: Washington University School of Medicine, St. Louis, MO, 2005.
Certification: Pediatric Infectious Diseases, 1997.
El Feghaly R, Stauber J, Tarr PI, Haslam DB. Intestinal inflammatory biomarkers and outcome in pediatric Clostridium difficile infections. J Pediatr. 2013. In press.
El Feghaly R, Stauber J, Tarr PI, Haslam DB. Viral co-infections are common and are associated with higher bacterial burden in children diagnosed with Clostridium difficile colitis. JPGN. In press.
El Feghaly R, Stauber J, Deych E, Gonzales C, Tarr PI, Haslam DB. Markers of intestinal Inflammation, not bacterial burden, correlate with clinical outcomes in Clostridium difficile infection. Clin Infect Dis. 2013;56(12):1713-21.
Bobo, LD, El Feghaly R, Chen YS, Dubberke ER, Han Z, Baker A, Li J, Burnham CA, Haslam DB. MAPK-activated protein kinase 2 contributes to Clostridium difficile-associated inflammation. Infect Immun. 2013;81(3):713-722.
Chumbler NM, Farrow MA, Lapierre L, Franklin J, Haslam DB, Goldenring J, Lacey B. Clostridium difficile Toxin B causes epithelial cell necrosis through an autoprocessing-independent mechanism. Plos Pathogens. 2012;8(12):1-12.
Saenz JB, Li J, Haslam DB. The MAP kinase-activated protein kinase 2 (MK2) contributes to the Shiga toxin-induced inflammatory response. Cell Microbiol. 2010;12:516-29.
Saenz JB, Sun, W, Chang, JW, Li, J, Bursulaya, B., Gray, NS, Haslam, DB. Golgicide A reveals essential roles for GBF1 in Golgi assembly and function. Nature Chem Biol.2009;5(3):157-65.
Andrew B. Herr, PhD
Structural biology and biophysics of antibodies; immune receptors; bacterial surface proteins
Andrew Herr, PhD, is an associate professor in the Division of Immunobiology and Center for Systems Immunology, with an affiliate appointment in the Division of Infectious Diseases. Dr. Herr completed his thesis work in molecular biophysics from Washington University in St. Louis, and completed his postdoctoral work in structural immunology at the California Institute of Technology as a Damon Runyon Research Fellow. He was recruited to the University of Cincinnati College of Medicine as an Ohio Eminent Scholar in Structural Biology before moving to Cincinnati Children’s Hospital.
Dr. Herr solved the first structure of a human IgA1 antibody bound to its cognate Fc receptor while at Caltech, and his lab has continued to study antibodies and immune receptors implicated in autoimmune diseases. In addition, the lab is studying a family of related collagen-specific immune receptors such as glycoprotein VI, which activates platelets upon exposure to fibrous collagen. The Herr lab also studies mechanisms of bacterial pathogenesis. Specifically, they discovered the zinc-dependent mechanism of intercellular adhesion in bacterial biofilms formed by Staphylococcus epidermidis and S. aureus. Biofilms are specialized bacterial colonies that are highly resistant to antibiotics and immune responses, so developing novel therapies to prevent biofilm formation is of high importance.
Before joining the faculty at Cincinnati Children’s, Dr. Herr was an Ohio Eminent Scholar in Structural Biology at the University of Cincinnati College of Medicine and served as an associate director of the Cincinnati Medical Scientist (MD/PhD) Training Program. Dr. Herr received the 2014 Emerging Entrepreneurial Achievement Faculty Award from UC for his work to commercialize a novel anti-infective therapy based on his lab’s research.
BA: Oral Roberts University, Tulsa, OK, 1993.
PhD: Washington University Medical School, St. Louis, MO, 1999.
Postdoc: California Institute of Technology, Pasadena, CA, 2003.
Li X, Shu C, Yi G, Chaton CT, Shelton CL, Diao J, Zuo X, Kao CC, Herr AB, Li P. Cyclic GMP-AMP synthase is activated by double-stranded DNA-induced oligomerization. Immunity. 2013 Dec 12;39(6):1019-31.
Conrady DG, Wilson JJ, Herr AB. Structural basis for Zn2+-dependent intercellular adhesion in staphylococcal biofilms. Proc Natl Acad Sci U S A. 2013 Jan 15;110(3):E202-11.
Herr AB, Conrady DG. Thermodynamic analysis of metal ion-induced assembly. Methods Enzymol. 2011;488:101-21.
Herr AB, Farndale RW. Structural insights into the interactions between platelet receptors and fibrillar collagen. J Biol Chem. 2009 Jul 24;284(30):19781-5.
Horii K, Brooks MT, Herr AB. Convulxin forms a dimer in solution and can bind eight copies of glycoprotein VI: Implications for platelet activation. Biochemistry. 2009 Apr 7;48(13):2907-14.
Conrady DG, Brescia CC, Horii K, Weiss AA, Hassett DJ, Herr AB. A zinc-dependent adhesion module is responsible for intercellular adhesion in staphylococcal biofilms. Proc Natl Acad Sci U S A. 2008 Dec 9;105(49):19456-61.
Gomes, MM, SB Wall, K Takahashi, J Novak, MB Renfrow, and AB Herr. Analysis of IgA1 N-glycosylation and its contribution to FcaRI binding. Biochemistry. 2008 Oct 28;47(43):11285-99.
Horii K, Kahn ML, Herr AB. Structural basis for platelet collagen responses by the immune-type receptor glycoprotein VI. Blood. 2006 Aug 1;108(3):936-42.
Herr, AB, ER Ballister, and PJ Bjorkman. Insights into IgA-mediated immune responses from the crystal structures of human FcaRI and its complex with IgA1-Fc. Nature. 2003 Jun 5;423(6940):614-20.
Ornitz DM, Herr AB, Nilsson M, Westman J, Svahn CM, Waksman G. FGF binding and FGF receptor activation by synthetic heparan-derived di- and trisaccharides. Science. 1995 Apr 21;268(5209):432-6.
Studies of metal-dependent intercellular adhesion in Staphylococcal biofilms. Principal Investigator. National Institutes of Health. Sep 2011 – Jun 2015. NIH R01 GM094363.
Analytical tools for the analysis of clustered O-glycans in clinical samples. Principal Investigator of Sub-contract. National Institutes of Health. Sep 2011 – Jul 2015. NIH R01 GM098539.
Margaret K. Hostetter, MD BK Rachford Professor and Chair, Department of Pediatrics
BK Rachford Professor and Chair, Department of Pediatrics
Bacterial and fungal infections; medical evaluation of internationally adopted children
Grant C. Paulsen, MD
Dr. Paulsen began his research career investigating Epstein-Barr virus (EBV) and its impact on the immune system of pediatric renal transplant recipients as well as analysis of risk factors for EBV viremia after renal transplantation. These results were presented at the World Transplant Congress 2014 with the full manuscript in process.
MD: University of Colorado Health Sciences Center, Denver, CO, 2005.
Residency: Internal Medicine and Pediatrics, University of North Carolina, Chapel Hill, NC, 2005-2009.
Fellowship: Adult and Pediatric Infectious Diseases, University of Alabama, Birmingham, AL 2010-2014.
Certification: Internal Medicine, 2009; Pediatrics, 2010.
Elizabeth P. Schlaudecker, MD, MPH
Global health; influenza; prevention of infant infection with maternal immunization
Elizabeth P. Schlaudecker, MD, MPH, is a faculty member in the Division of Infectious Diseases and the Global Health Center. Dr. Schlaudecker received her medical degree and master's in public health from the University of Cincinnati and completed a pediatrics residency and chief residency at Cincinnati Children's.
Dr. Schlaudecker was awarded a Fogarty International Clinical Research Fellowship from the National Institutes of Health in 2009, and she investigated the etiology and seasonality of viral respiratory disease in Honduran children under the age of five. She was awarded the Pediatric Infectious Diseases Society Blue Ribbon Research award in 2011 for similar work in Bangladesh. After joining the faculty of Cincinnati Children's in 2011, she continued her influenza research with a Procter Scholars award. Dr. Schlaudecker has traveled to Honduras, the Dominican Republic, Costa Rica, Ecuador, Kenya, South Africa, and Cameroon as part of her clinical and research training.
MD: University of Cincinnati, Cincinnati, OH, 2003.
Residency: Pediatrics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2006.
Chief Residency: Pediatrics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2007.
Fellowship: Infectious Diseases, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2011.
MPH: Public Health, University of Cincinnati, Cincinnati, OH, 2011.
Certification: Pediatrics, 2006.
Samir S. Shah, MD, MSCE Director, Division of Hospital Medicine
Director, Division of Hospital Medicine
Attending Physician, Division of Hospital Medicine
Pediatric infectious diseases; pediatric hospital medicine; community-acquired pneumonia; bacterial meningitis; observational study designs; administrative data sources
Samir S. Shah, MD, MSCE, is a pediatric infectious diseases and pediatric hospital medicine physician whose research focuses on improving the efficiency and quality of care of children hospitalized with common, serious infections such as pneumonia and meningitis. Ongoing projects include studying the comparative effectiveness of different antibiotics in the treatment of community-acquired pneumonia and developing novel databases to conduct comparative effectiveness research.
Dr. Shah served as associate chair of the National Pneumonia Guidelines Committee, jointly sponsored by the Infectious Diseases Society of America and the Pediatric Infectious Diseases Society. He is also an executive council member of the Pediatric Research in Inpatient Settings (PRIS) Network.
Dr. Shah is deputy editor of the Journal of Hospital Medicine, the official journal of the Society of Hospital Medicine. He also serves as associate editor of the Journal of the Pediatric Infectious Diseases Society and on the editorial board of JAMA Pediatrics. In addition, he is editor or co-editor of 9 books in the fields of pediatrics and infectious diseases including The Philadelphia Guide: Inpatient Pediatrics (Lippincott Williams & Wilkins), and Symptom-Based Diagnosis in Pediatrics (McGraw-Hill Education).
Dr. Shah has received several prestigious research awards, including the Society of Hospital Medicine Excellence in Research Award, the Pediatric Infectious Diseases Society Young Investigator Award, and the Society of Hospital Medicine Teamwork in Quality Improvement Award.
Mittal V, Hall M, Morse R, Wilson KM, Mussman G, Hain P, Montalbano A, Parikh K, Mahant S, Shah SS. Impact of institutional bronchiolitis clinical practice guideline implementation on tests and treatments. J Pediatr. 2014;165:570-576.
Neuman MI, Hall M, Gay JC, Blaschke AJ, Williams DJ, Parikh K, Hersh AL, Brogan TV, Gerber JS, Grijalva CG, Shah SS. Readmissions among children previously hospitalized with pneumonia. Pediatrics. 2014;134:100-109.
Queen MA, Myers AL, Hall M, Shah SS, Williams DJ, Auger KA, Jerardi KE, Statile AM, Tieder JS. Comparative effectiveness of empiric antibiotics for children hospitalized with community-acquired pneumonia. Pediatrics. 2014;133:e23-e29.
Williams DJ, Hall M, Shah SS, Parikh K, Tyler A, Neuman MI, Hersh AL, Brogan TV, Blaschke AJ, Grijalva CG. Narrow vs. broad-spectrum antimicrobial therapy for children hospitalized with pneumonia. Pediatrics. 2013;132:e1141-e1148.
Florin TA, French B, Zorc JJ, Alpern ER, Shah SS. Variation in emergency department diagnostic testing and association with outcomes in children with community-acquired pneumonia. Pediatrics. 2013;132:237-244.
Myers AL, Hall M, Tieder JS, Jerardi K, Auger K, Wiggleton C, Statile A, Williams DJ, McClain L, Shah SS. Prevalence of bacteremia in hospitalized pediatric patients with community-acquired pneumonia. Pediatr Infect Dis. J 2013;32:736-740.
Blaschke AJ, Byington CL, Ampofo K, Pavia AT, Heyrend C, Rankin SC, McGowan KL, Harris MC, Shah SS. Species-specific PCR improves detection of bacterial pathogens in parapneumonic empyema compared with 16S PCR and culture. Pediatr Infect Dis J. 2013;32:302-303.
Neuman MI, Hall M, Hersh AL, Brogan TV, Parikh K, Newland JG, Blaschke AJ, Williams DJ, Grijalva CG, Tyler A, Shah SS. Influence of hospital guidelines on management of children hospitalized with pneumonia. Pediatrics. 2012;130:e823-e830.
Ambroggio LV, Taylor JA, Tabb LP, Newschaffer CJ, Evans AA, Shah SS. Comparative effectiveness of beta-lactam monotherapy and beta-lactam-macrolide combination therapy in children hospitalized with community-acquired pneumonia. J Pediatr. 2012;161:1097-1103.
Brogan TV, Hall M, Williams DJ, Neuman MI, Grijalva CG, Farris RWD, Shah SS. Variability in processes of care and outcomes among children hospitalized with community-acquired pneumonia. Pediatr Infect Dis J. 2012;31:1036-1041.
Understanding quality and costs in congenital heart surgery. Co-Investigator. National Heart, Lung, and Blood Institute (NHLBI). April 2014-March 2019.
Improving post-discharge outcomes by facilitating family-centered transitions from hospital to home. Principal Investigator. Patient-Centered Outcomes Research Institute. May 2014-Jan 2017.
Reduced variability in the management of community-acquired pneumonia. Principal Investigator. Place Outcomes Award. July 2013-June 2015
Comparative effectiveness of home intravenous vs. oral antibiotic therapy for serious bacterial infections. Site Principal Investigator. Patient-Centered Outcomes Research Institute. Jan 2013-Jan 2016.
Mary Allen Staat, MD, MPH Director, International Adoption Center
Director, International Adoption Center
Helicobacter pylori, rotavirus epidemiology, travel medicine and infectious diseases of international adoptees
Epidemiology of enteric infections and surveillance of infectious diseases
Mary Allen Staat, MD, MPH, is director of the International Adoption Center and a member of the Infectious Disease Division at Cincinnati Children's Hospital Medical Center.
Dr. Staat is a board-certified pediatrician and is also board-certified in Infectious Disease and Preventive Medicine. She is an associate professor of Pediatrics at the University of Cincinnati and a faculty member of the Cincinnati Children's Hospital Research Foundation.
MD: University of Kentucky, Lexington, Ky., 1986.
MPH: Johns Hopkins University, Baltimore, Md., 1991.
Residency: Pediatrics, Baylor College of Medicine, Houston, Texas, 1986-1989; Preventive Medicine, Johns Hopkins University, Baltimore, Md., 1990-1994.
Fellowship: Infectious Diseases, Baylor College of Medicine, Houston, Texas, 1989-1990; Epidemiology, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Rockville, Md., 1990-1993.
Certification: Pediatrics, 1989; Preventive Medicine, 1996; Pediatric Infectious Diseases, 1999.
Staat MA, Rice MA, Donauer S, Payne DC, Bresee JS, Mast TC, Curns AT, Cortese MM, Connelly B, McNeal M, Ward RL, Bernstein DI, Parashar UD, Salisbury S. Estimating the rotavirus hospitalization disease burden and trends, using capture-recapture methods. Pediatr Infect Dis J. 2010 Dec;29(12):1083-6.
Abdulla RY, Rice MA, Donauer S, Hicks KR, Poore D, Staat MA. Hepatitis A in internationally adopted children: screening for acute and previous infections. Pediatrics. 2010 Nov;126(5):e1039-44.
Staat MA, Stadler LP, Donauer S, Trehan I, Rice M, Salisbury S. Serologic testing to verify the immune status of internationally adopted children against vaccine preventable diseases. Vaccine. 2010 Nov 23;28(50):7947-55.
Fairbrother G, Cassedy A, Ortega-Sanchez IR, Szilagyi PG, Edwards KM, Molinari NA, Donauer S, Henderson D, Ambrose S, Kent D, Poehling K, Weinberg GA, Griffin MR, Hall CB, Finelli L, Bridges C, Staat MA; New Vaccine Surveillance Network (NVSN). High costs of influenza: Direct medical costs of influenza disease in young children. Vaccine. 2010 Jul 12;28(31):4913-9.
Mast TC, Walter EB, Bulotsky M, Khawaja SS, DiStefano DJ, Sandquist MK, Straus WL, Staat MA. Burden of childhood rotavirus disease on health systems in the United States. Pediatr Infect Dis J. 2010 Feb;29(2):e19-25. Payne DC, Szilagyi PG, Staat MA, Edwards KM, Gentsch JR, Weinberg GA, Hall CB, Curns AT, Clayton H, Griffin MR, Fairbrother G, Parashar UD. Secular variation in United States rotavirus disease rates and serotypes: implications for assessing the rotavirus vaccination program. Pediatr Infect Dis J. 2009 Nov;28(11):948-53. Dickey M, Jamison L, Michaud L, Care M, Bernstein DI, Staat MA. Rotavirus meningoencephalitis in a previously healthy child and a review of the literature. Pediatr Infect Dis J. 2009 Apr;28(4):318-21.
Linam WM, Margolis PA, Staat MA, Britto MT, Hornung R, Cassedy A, Connelly BL. Risk factors associated with surgical site infection after pediatric posterior spinal fusion procedure. Infect Control Hosp Epidemiol. 2009 Feb;30(2):109-16. Stadler LP, Mezoff AG, Staat MA. Hepatitis B virus screening for internationally adopted children. Pediatrics. 2008 Dec;122(6):1223-8.
Yee EL, Staat MA, Azimi P, Bernstein DI, Ward RL, Schubert C, Matson DO, Turcios-Ruiz RM, Parashar U, Widdowson MA, Glass RI. Burden of rotavirus disease among children visiting pediatric emergency departments in Cincinnati, Ohio, and Oakland, California, in 1999-2000. Pediatrics. 2008 Nov;122(5):971-7.
Sing Sing Way, MD, PhD Pauline and Lawson Reed Chair, Division of Infectious Diseases
Pauline and Lawson Reed Chair, Division of Infectious Diseases
Infectious diseases; prenatal infection; immunology
Dr. Way is an infectious disease physician-scientist. He cares for infants and children with infection related illness, and provides consultation in the diagnosis and prevention diseases caused by communicable agents. Dr. Way supervises an active basic research laboratory that uses basic immunological approaches to investigate ways to boost host defense and protection against infection. Ongoing projects investigate the immune basis responsible for enhanced susceptibility to infection during pregnancy, the immune pathogenesis of pregnancy complications that occur with maternal infection, and the basic signals required for stimulating immune cell activation.
Dr. Way trained in the combined MD/PhD program at the Albert Einstein College of Medicine, pediatric residency at the University of California San Francisco, and infectious disease fellowship at the University of Washington. During fellowship training, Dr. Way began investigating the basic immunology and immune pathogenesis of infectious diseases relevant to human, and in particular, infant and child health.
Dr. Way’s research has been supported by the National Institutes of Health since 2006. Dr. Way’s research has been described in many publications in numerous prestigious scientific journals including Nature, Cell Host & Microbe, PLoS Pathogens, and The Journal of Immunology. The past and ongoing work has also been recognized by numerous prestigious awards including the Infectious Diseases Society of America Wyeth Young Investigator Award, a Basil O’ Conner Award from the March of Dimes Foundation, and the Investigator in Pathogenesis of Infectious Diseases award from the Burroughs Wellcome Fund.
MD PhD: Albert Einstein College of Medicine, Bronx, NY, 1999.
Residency: University of California San Francisco, San Francisco, CA, 2001.
Fellowship: University of Washington, Seattle, WA, 2004.
Rowe JH, Ertelt JM, Xin L, Way SS. Pregnancy imprints regulatory memory that sustains anergy to fetal antigen. Nature. 490: 102-106. 2012.
Rowe JH, Ertelt JM, Xin L, Way SS. Listeria monocytogenes cytoplasmic entry induces fetal wastage by disrupting maternal Foxp3+ regulatory T cell-sustained fetal tolerance. PLoS Pathog. 8: e1002873. 2012.
Rowe JH, Ertelt JM, Way SS. Innate IFN-g is essential for Programmed death ligand-1-mediated T cell stimulation following Listeria monocytogenes infection. J Immunol. 189: 876-84. 2012.
Rowe JH, Ertelt JM, Way SS. Foxp3+ regulatory T cells, immune stimulation, and host defense against infection. Immunology. 136:1-10. 2011.
Ertelt JM, Johanns TM, Mysz MA, Nanton MR, Rowe JH, Aguilera MN, Way SS. Selective culling of high avidity antigen-specific CD4+ T cells after virulent Salmonella infection. Immunology. 134: 487-97. 2011.
Ertelt JM, Rowe JH, Mysz MA, Singh C, Roychowdhury M, Aguilera MN, Way SS. Foxp3+ regulatory T cells impede the priming of protective CD8+ T cells. J Immunol. 187: 2569-77. 2011.
Rowe JH, Ertelt JM, Aguilera MN, Farrar MA, Way SS. Foxp3+ regulatory T cell expansion required for sustaining pregnancy compromises host defense against prenatal bacterial pathogens. Cell Host Microbe. 10:54-64. 2011.
Johanns TM, Law CY, Kalekar LA, O’Donnell H, Ertelt JM, Rowe JH, Way SS. Early eradication of persistent Salmonella infection primes antibody-mediated protective immunity to recurrent infection. Microbes Infect. 13: 322-330. 2011.
Han JY, Hanson DC, Way SS. Herpes Zoster and meningitis due to reactivation of varicella vaccine virus in a immunocompetent child. Pediatr Infect Dis J. 30:266-268. 2011.
Ertelt JM, Johanns TM, Rowe JH, Way SS. IL-21-independent pathogen-specific CD8+ T cell expansion, and IL-21-dependnent suppression of CD4+ T cell IL-17 production. Immunology. 131: 183-191. 2010.
Maternal regulatory T cells control the immune pathogenesis of prenatal infection. Principal Investigator in the Pathogenesis of Infectious Disease. Burroughs Wellcome Fund. 2012-2017.
The immune pathogenesis of prenatal Listeria monocytogenes infection. Principle Investigator. National Institute of Allergy and Infectious Diseases (NIAID). 2012-2017. R01-AI100934.
Regulatory T cells dictate the immunity during persistent Salmonella infection. Principle Investigator. National Institute of Allergy and Infectious Diseases (NIAID). 2010-2015. R01-AI087830.
Kevin J. Downes, MD Staff Physician, Division of Infectious Diseases
Staff Physician, Division of Infectious Diseases
Clinical Fellow, Division of Clinical Pharmacology
Pediatric infectious diseases
Antimicrobial clinical pharmacology; acute kidney injury; cystic fibrosis
MD: University of Pennsylvania School of Medicine, Philadelphia, PA, 2008.
Residency: Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2011.
Fellowship: Pediatric Infectious Diseases, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2014; Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2014.
Certification: Pediatrics, 2011.
Shah SS, Downes KJ, Elliott MR, Bell LM, McGowan KL, Metlay JP. How long does it take to “rule out” bacteremia in children with central venous catheters? Pediatrics. 2008 Jan; 121(1): 135-41.
Downes KJ, Metlay JP, Bell LM, McGowan KL, Elliott MR, Shah SS. Polymicrobial bloodstream infections among children and adolescents with central venous catheters evaluated in ambulatory care. Clin Infect Dis. 2008 Feb 1; 46(3): 387-94.
Downes KJ, Hahn A, Wiles J, Courter JD, Vinks AA. Dose optimisation of antibiotics in children: the application of pharmacokinetics/pharmacodynamics in paediatrics. Int J Antimicrob Agents. 2014 Mar;43(3):223-30.
Downes KJ, Rao MB, Kahill L, Nguyen H, Clancy JP, Goldstein SL. Daily serum creatinine monitoring promotes earlier detection of acute kidney injury in children and adolescents with cystic fibrosis. J Cyst Fibros. 2014 Jul;13(4):435-41.
Kelly R. Hicks, MSN, APRN, CNS Clinical Nurse Specialist, Division of Infectious Diseases
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