Leukemia and Lymphoma Program

  • Meet the Team: Pediatric Leukemia & Lymphoma Specialists

    The Leukemia and Lymphoma Center is home to specialists with a wide variety of backgrounds and areas of focus. As a team, this diversity makes us better prepared to care for your child’s unique needs. Learn more about our faculty and staff.

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    Director

    A photo of Dr. Perentesis.

    John P. Perentesis, MD, FAAP
    Director, Division of Oncology and Cancer Programs

    513-636-8241

    john.perentesis@cchmc.org

    A photo of Dr. Perentesis.

    John P. Perentesis, MD, FAAP

    Director, Division of Oncology and Cancer Programs

    Deb Kleisinger Endowed Chair of Novel Cancer Treatments

    Executive Co-Director, Cancer and Blood Diseases Institute

    Director, Leukemia / Lymphoma Program

    Cincinnati Children's Principal Investigator, Children’s Oncology Group (COG)

    Cincinnati Children's Principal Investigator, National Cancer Institute Pediatric Phase 1 Consortium

    Professor, UC Department of Pediatrics

    Phone: 513-636-8241

    Email: john.perentesis@cchmc.org

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    Specialties

    Clinical Interests

    Acute myeloid leukemia; neuroblastoma; PNET / Ewing's sarcoma and osteosarcoma; new anticancer drug development; Phase I clinical trials

    Research Interests

    Molecular etiology and pharmacogenetics of pediatric cancers; Down syndrome-associated leukemia; new anticancer drug development

    Biography

    John P. Perentesis, MD, is a nationally recognized expert in the development of new drugs and molecular therapies for pediatric and young adult cancers and leukemia. His laboratory has developed novel anticancer drugs, and discovered genes important in the growth of normal and malignant cells. His laboratory is also developing the use of tumor and patients genetics research for personalizing therapies. In clinical research, he serves in leadership roles for the National Cancer Institute’s Investigational Drug Steering Committee and the NCI Pediatric Phase I Consortium.

    In 2010, Dr. Perentesis was elected by pediatric oncologists from across the country to the national Executive Committee for the NCI-funded Children’s Oncology Group (COG). The COG is the world's largest, cooperative children's cancer research entity. He also is in leadership efforts in the COG for new therapies for leukemia, and adolescent and young adult cancers.

    Education and Training

    MD: University of Michigan, Ann Arbor, MI, 1980.

    Residency: University of Minnesota Medical School, Minneapolis, MN, 1983.

    Fellowship: University of Minnesota Medical School, Minneapolis, MN, 1986.

    Postdoctoral: University of Minnesota Medical School, Minneapolis, MN, 1986.

    Certification: Pediatrics, 1989; Hematology/Oncology, 1990.

    Publications

    View PubMed Publications

    Grants

    The Children's Oncology Group Chair Grant. Site Principal Investigator. National Institutes of Health. Mar 2008 - Mar 2013. #U10 CA 098543.

    Children's Oncology Group Phase I. Site Principal Investigator. National Institutes of Health. Aug 2002 - Jul 2012. #U01 CA 097452.

    Children's Oncology Group New Publication Committee. National Institutes of Health. Sep 2006 - Jul 2012. #U01 CA 97542 .

    Cincinnati Children's Hyundai Scholar in Childhood Cancer Drug Development. Hyundai Hope on Wheels. Oct 2010 - Oct 2011.

    Oncology

    Michael J. Absalon, MD, PhD

    Assistant Professor, UC Department of Pediatrics

    Phone: 513-636-4266

    Fax: 513-636-3549

    Email: michael.absalon@cchmc.org

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    Specialties

    Relapsed leukemia; lymphoma; new therapeutics; ataxia telangiectasia; DNA damage response mechanisms

    Education and Training

    BS: Lewis and Clark College, Portland, OR, 1987.

    PhD: Massachusetts Institute of Technology, Cambridge, MA, 1994.

    MD: Oregon Health Sciences University, Portland, OR, 1998.

    Fellowship: St. Jude Children's Research Hospital, Memphis, TN, 2005.

    Publications

    View PubMed Publications
    A photo of Denise Adams.

    Denise M. Adams, MD
    Marjory J. Johnson Chair of Vascular Tumor Translational Research

    513-636-4266

    denise.adams@cchmc.org

    Denise M. Adams, MD

    Marjory J. Johnson Chair of Vascular Tumor Translational Research

    Medical Director, Comprehensive Hemangioma and Vascular Malformation Center

    Fellowship Director, Hematology / Oncology

    Professor, UC Department of Pediatrics

    Phone: 513-636-4266

    Fax: 513-636-3549

    Email: denise.adams@cchmc.org

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    Biography

    Dr. Denise Adams is the medical director of the Hemangioma and Vascular Malformations Center. She is one of the medical physicians who evaluate patients to identify the proper diagnosis and develop with families an optimal treatment plan. She is trained in hematology/oncology. Dr. Adams obtained her schooling from Georgetown University. She first came to Cincinnati Children’s in 2003, and has strived since that time to provide exemplary care for the children served here within our multidisciplinary team. One of the vascular team’s main priorities has been establishing standards of care for patients with these diagnoses so they can follow outcome measures. Of key interest to Dr. Adams, is the improving of the care of patients with kaposiform hemangioendotheliomas (KHE) and other rare vascular tumors. Dr. Adams was awarded the Marjory J. Johnson Chair of Vascular Tumor Translational Research for her impact and leadership in the advancement of knowledge of vascular anomalies and the transformation of care for her patients. Dr. Adams has led one of the first prospective NIH-funded trials for the treatment of complicated vascular anomalies; further studies are in development. Clinical trial summaries can be seen on www.ClinicalTrial.gov.

    Education and Training

    MD: Georgetown University School of Medicine, 1988.

    Post-Graduate: Georgetown University, 1983.

    BSN: Georgetown University, 1982.

    Publications

    View PubMed Publications

    A photo of Karen Burns.

    Karen C. Burns, MD, MS
    Director, Cancer Survivorship Center

    513-636-4266

    karen.burns@cchmc.org

    Karen C. Burns, MD, MS

    Director, Cancer Survivorship Center

    Assistant Professor, UC Department of Pediatrics

    Phone: 513-636-4266

    Fax: 513-636-3549

    Email: karen.burns@cchmc.org

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    Education and Training

    BA: University of Pennsylvania, Philadelphia, PA, 1995.

    MD: Temple University, Philadelphia, PA, 1999.

    Residency: Pediatrics, St. Christopher's Hospital for Children in Philadelphia, PA, 2002.

    MS: Medical College of Wisconsin, 2005.

    Fellowship: Medical College of Wisconsin, 2005.

    Publications

    View PubMed Publications

    Adrienne M. Hammill, MD, PhD

    Assistant Professor, UC Department of Pediatrics

    Phone: 513-636-0673

    Email: adrienne.hammill@cchmc.org

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    Specialties

    Hemangiomas and vascular malformations; genetic predispositions to cancer

    Biography

    Dr. Adrienne M. Hammill is trained in pediatrics and hematology/oncology and is particularly interested in bringing new and/ or better medical therapy options to the treatment of vascular anomalies. She is one of the medical physicians for the Hemangioma and Vascular Malformations team. She obtained her schooling at the University of Texas Southwestern, and completed her residency and fellowship here at Cincinnati Children’s Hospital Medical Center. She is a dedicated professional and strives to improve the treatment of those she cares for. Dr. Hammill has a special interest in Sturge Weber syndrome and due to her dedicated involvement, Cincinnati Children’s has been named a site for the brain vascular malformations consortium, which is a clinical research group funded by National Institutes of Health and the rare disease network. She was nominated as a finalist for The Making a Difference Award in 2013 through the Patient Advisory Council. This nomination for staff was for their efforts to improve the patient’s experience in terms of lives saved, errors caught, kindness shown, and battles fought. A Cincinnati Children’s patient nominated Dr. Adrienne Hammill for making her feel secure and talking to her one-on-one as a friend not a doctor.

    Education and Training

    MD: University of Texas Southwestern Medical School, Dallas, TX, 2004.

    PhD: University of Texas Southwestern Graduate School of Biomedical Sciences, Dallas, TX, 2004.

    Residency: Cincinnati Children’s Hospital Medical Center, Cincinnati, OH.

    Fellowship: Cincinnati Children’s Hospital Medical Center.

    Certification: Pediatrics, 2008.

    Publications

    View PubMed Publications

    A photo of Maureen O'Brien.

    Maureen M. O'Brien, MD, MS
    Associate Director, Leukemia / Lymphoma Program

    513-803-1678

    maureen.obrien@cchmc.org

    Maureen M. O'Brien, MD, MS

    Associate Director, Leukemia / Lymphoma Program

    Assistant Professor, UC Department of Pediatrics

    Phone: 513-803-1678

    Fax: 513-636-3549

    Email: maureen.obrien@cchmc.org

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    Specialties

    Clinical Interests

    Leukemia; lymphoma

    Research Interests

    Molecular etiology of pediatric leukemias, especially in children with Down syndrome; novel therapeutics for relapsed and high-risk leukemia and lymphoma

    Education and Training

    MD: Harvard Medical School, Boston, MA, 2000.

    Residency: Boston Combined Residency Program, Boston Children's Hospital and Boston Medical Center, Boston, MA, 2003.

    Fellowship: Stanford University School of Medicine, Stanford, CA, 2007.

    MS: Stanford University, Stanford, CA, 2008.

    Certification: Pediatrics, 2003; Pediatric Hematology/Oncology, 2009.

    Publications

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    Christine L. Phillips, MD

    Assistant Professor, UC Department of Pediatrics

    Phone: 513-803-1126

    Email: christine.phillips@cchmc.org

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    Specialties

    Leukemia and lymphoma; leukemia pharmacogenetics; translational and clinical development of new drugs for high-risk and relapsed leukemias

    Biography

    Christine Phillips, MD, is an oncologist with a clinical focus on leukemia and lymphoma and a clinical and translational research focus on the development of novel therapies for pediatric leukemia and in leukemia pharmacogenetics.

    Dr. Phillips earned her undergraduate degree in biochemistry and her medical degree from Indiana University, completed her residency in pediatrics at Children’s Memorial Hospital in Chicago, and her fellowship in pediatric hematology/oncology at Cincinnati Children’s, where she was co-chief fellow. She was a 2008 Hyundai Hope on Wheels Foundation Scholar.

    Education and Training

    MD: Indiana University School of Medicine, Indianapolis, IN, 2002.

    Residency:
    Pediatrics, Children’s Memorial Hospital, Chicago, IL, 2005.

    Fellowship:
    Pediatric Hematology/Oncology, Cincinnati Children’s Hospital Medical Center, 2010.

    Certification: Pediatrics, 2005; Pediatric Hematology/Oncology, 2011.

    Publications

    View PubMed Publications

    Blood and Marrow Transplant

    Jacob (Jack) J.H. Bleesing, MD, PhD

    Associate Professor, UC Department of Pediatrics

    Phone: 513-636-4266

    Fax: 513-636-3549

    Email: jack.bleesing@cchmc.org

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    Specialties

    Clinical Interests

    Immunobiology; translational research; immunologic methods development

    Research Interests

    Clinical investigation of primary immunodeficiency disorders (with emphasis on disorders of immuno dysregulation and B-cell disorders); immuno-reconstitution following blood and marrow transplantation; diagnostic immunology (with emphasis on flow cytometry) 

    Education and Training

    MD: University of Leiden, Leiden, The Netherlands, 1989.

    PhD: University of Leiden, Leiden, The Netherlands, 2002.

    Residency: Pediatrics, University of Florida, Gainesville, Florida, 1993.

    Fellowship: Allergy/Immunology, Duke University Medical Center, Durham, North Carolina, 1995.

    Fellowship: Clinical Laboratory Immunology, National Institutes of Health, Bethesda, Maryland, 2001.

    Publications

    View PubMed Publications
    A photo of Stella Davies.

    Stella M. Davies, MBBS, PhD, MRCP
    Director, Bone Marrow Transplantation and Immune Deficiency

    513-636-2469

    stella.davies@cchmc.org

    Stella M. Davies, MBBS, PhD, MRCP

    Director, Bone Marrow Transplantation and Immune Deficiency

    Jacob G. Schmidlapp Endowed Chair

    Professor, UC Department of Pediatrics

    Phone: 513-636-2469

    Fax: 513-636-3549

    Email: stella.davies@cchmc.org

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    Specialties

    Education and Training

    MBBS: University of Newcastle-Upon-Tyne, England, 1981.

    Clinical and Fellowship Training: The Royal Victoria Infirmary, Newcastle General Hospital and Great Ormond St. Hospital, 1981 to 1985.

    PhD: University of Newcastle-Upon-Tyne, England, 1989.

    Pediatric Fellowship: University of Minnesota, Minneapolis, MN, 1989 to 1993.

    Publications

    View PubMed Publications

    A photo of Lisa Filipovich.

    Alexandra (Lisa) H. Filipovich, MD
    Ralph J. Stolle Chair, Clinical Immunology

    513-803-3218

    lisa.filipovich@cchmc.org

    Alexandra (Lisa) H. Filipovich, MD

    Ralph J. Stolle Chair, Clinical Immunology

    Director, Immune Deficiency and Histiocytosis Program

    Medical Director, Diagnostic Immunology Laboratory

    Professor, UC Department of Pediatrics

    Phone: 513-803-3218

    Fax: 513-803-1969

    Email: lisa.filipovich@cchmc.org

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    Specialties

    Clinical Interests

    Primary immunodeficiencies; BMT for primary immunodeficiencies; hemophagocytic lymphocytosis; post-BMT immune reconstruction

    Research Interests

    Biology and genetics of hemophagocytic lymphohistiocytosis; investigation of hematopoietic cell transplantation for genetic immunodeficiencies; immunoreconstitution following pediatric stem cell transplantation

    Biography

    Lisa Filipovich, MD, began her career at the University of Minnesota where she received her medical degree in 1974 and completed fellowships in both immunopathology and pediatric immunology. She became a professor of pediatrics and served for 10 years as the head of the Division of Immunology at the University of Minnesota Medical School. Dr. Filipovich came to Cincinnati Children’s in 1996. She is currently the Ralph J. Stolle Chair in Clinical Immunology and the director of the Immune Deficiency and Histiocytosis program. She also serves as the medical director of the Diagnostic Immunology Laboratory at Cincinnati Children’s.

    Dr. Filipovich has a special interest in histiocytic disorders, especially hemophagocytic lymphohistiocytosis (HLH). Other interests include bone marrow transplant for primary immune deficiencies and post-BMT immune reconstitution. She serves as president of the Histiocyte Society, an international group of more than 200 physicians and scientists who are committed to improving the lives of patients with histiocytosis through research.

    Education and Training

    MD: University of Minnesota, Minneapolis, MN, 1974.

    Residency: University of Minnesota Hospitals, Minneapolis, MN 1975-1978.

    Fellowship: Immunopathology, Departments of Pediatrics, Laboratory Medicine and Pathology, University of Minnesota 1978-1979.

    Fellowship: Pediatric Immunology, Department of Pediatrics, University of Minnesota 1979-1980.

    Certification: Pediatrics, 1980.

    Publications

    View PubMed Publications

    Grants

    Gene Therapy for SCID-X1 Using Self-Inactivating Gamma. Principal Investigator. National Institutes of Health. Sep 2010-Aug 2015. #U01 AI 087628.

    Rare Diseases Clinical Consortia for the Rare Diseases. Principal Investigator. National Institutes of Health. Sep 2009-Aug 2014. #U54 AI 082973.

    Hypoxia and potassium channel activity in T Lymphocytes. Principal Investigator. National Institutes of Health. Jun 2009-Jun 2014. #R01 CA 095286.

    A photo of Richard E. Harris.

    Richard E. Harris, MD
    Director, Bone Marrow Failure Clinic, Bone Marrow Transplantation & Immune Deficiency

    513-636-8610

    richard.harris@cchmc.org

    Richard E. Harris, MD

    Director, Bone Marrow Failure Clinic, Bone Marrow Transplantation & Immune Deficiency

    Professor, UC Department of Pediatrics

    Phone: 513-636-8610

    Fax: 513-636-7951

    Email: richard.harris@cchmc.org

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    Specialties

    Clinical Interests

    Bone marrow failure syndromes such as Fanconi anemia; Shwachman-Diamond syndrome; dyskeratosis congenita; congenital amegakaryocytic thrombocytopenia; Diamond-Blackfan anemia; severe aplastic anemia

    Research Interests

    Transplantation for children with bone marrow failure syndromes (Fanconi anemia, Shwachman-Diamond syndrome, dyskeratosis congenita, amegakaryocytic thrombocytopenia, Diamond-Blackfan anemia) and aplastic anemia. Cytogenetic abnormalities in Fanconi anemia.

    Biography

    Dr. Harris's primary interest is in aplastic anemia and the various forms of hereditary bone marrow failure syndromes. He is active with the Fanconi Anemia Research Fund presenting at both the annual family meeting and the annual scientific meeting. Likewise he is active in the field of Shwachman-Diamond syndrome and is developing a US / Canadian SDS Registry. He also is participating in the development of the International SDS Registry. He is director of the Bone Marrow Failure Clinic at Cincinnati Children's Hospital where several hundred children are followed with these disorders. He is active in developing safe approaches to bone marrow transplantation for children with these disorders. His interest in these areas were recognized by the presentation to him of the Lifetime Achievement Award by the Fanconi Anemia Research Fund in 2005.

    Outside of his medical interests, he is a scoutmaster of a very active and large Boy Scout Troop in Cincinnati and has been presented the Silver Beaver Award for his scouting activities, the highest award a volunteer scouter can receive.

    Education and Training

    MD: University of Virginia School of Medicine, Charlottesville, VA, 1973. 

    Residency: Pediatrics, Vanderbilt University Medical Center, Nashville, Tenn., 1973-1976.

    Fellowship: Pediatric Hematology / Oncology, James Whitcomb Riley Hospital for Children, Indianapolis, Ind., 1976-1979.

    Certification: Pediatrics, 1978; Pediatric Hematology / Oncology, 1980.

    Publications

    View PubMed Publications

    Sonata Jodele, MD

    Associate Professor, UC Department of Pediatrics

    Phone: 513-636-1565

    Fax: 513-636-3549

    Email: sonata.jodele@cchmc.org

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    Specialties

    Bone marrow transplantation

    Education and Training

    MD: Vilnius University School of Medicine, 1988-1994.

    Residency: Pediatrics, Downstate HSC at Brooklyn, Brooklyn, NY, 1998-2001.

    Fellowship: Pediatric Hematology Oncology, Children's Hospital Los Angeles and Saban Research Institute, Keck School of Medicine University of Southern California, Los Angeles, CA, 2001-2004.

    Certifications: Pediatrics, 2001; Pediatric Hematology / Oncology, 2004.

    Licenses: California, 2001-present; Ohio, 2004-present.

    Publications

    View PubMed Publications

    Michael B. Jordan, MD

    Associate Professor, UC Department of Pediatrics

    Phone: 513-636-7287

    Fax: 513-803-1969

    Email: michael.jordan@cchmc.org

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    Specialties

    Clinical Interests

    Histiocytic disorders: HLH and LCH

    Research Interests

    Better understanding histiocytic disorders and developing novel therapies for them; regulation of the immune response; immunotherapy of cancer

    Education and Training

    MD: UT Southwestern, Dallas, TX, 1993.

    Residency: Children's Hospital of Dallas, 1996.

    Fellowship: The Children's Hospital (Denver), 2002.

    Certification: American Board of Pediatrics, 1996; Sub-board of Pediatric Heme/Onc, 2002.

    Publications

    View PubMed Publications

    Parinda A. Mehta, MD

    Associate Professor, UC Department of Pediatrics

    Phone: 513-636-4913

    Fax: 513-803-1969

    Email: parinda.mehta@cchmc.org

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    Education and Training

    Fellowship: Cincinnati Children's Hospital Medical Center, 2005.

    Residency: Upstate Medical University (UMU) - State University of New York (SUNY), Syracuse, NY, 2002.

    MD: G.S. Medical College and K.E.M Hospital, Mumbai, India, 1993.

    BA: Graduated from Parle College, Mumbai, India, 1988.

    Certification: Board Certification: Pediatrics, 2002; Board Certification: Pediatric Hematology Oncology; License: State of Ohio.

    Publications

    View PubMed Publications

    Therapeutic Nuclear Medicine

    A photo of Michael J. Gelfand.

    Michael J. Gelfand, MD
    Chief, Section of Nuclear Medicine, Department of Radiology and Medical Imaging

    513-636-7650

    michael.gelfand@cchmc.org

    Michael J. Gelfand, MD

    Chief, Section of Nuclear Medicine, Department of Radiology and Medical Imaging

    Professor, UC Department of Radiology

    UC Department of Pediatrics

    Phone: 513-636-7650

    Fax: 513-636-8145

    Email: michael.gelfand@cchmc.org

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    Specialties

    Nuclear medicine

    Biography

    Michael J. Gelfand, MD, is chief of the Section of Nuclear Medicine at Cincinnati Children's Hospital Medical Center.

    He received his BA from the University of Michigan and his MD from Stanford University. After two years at the National Institutes of Health, he completed residencies in pediatrics at Cincinnati Children's and nuclear medicine at the University of Cincinnati Medical Center.

    Dr. Gelfand's research interests include I-123-MIBG imaging of neuroblastoma, new applications of hybrid imaging (PET/CT, SPECT/CT, PET/MRI) in pediatrics, and radiation dose reduction in nuclear medicine and hybrid imaging.

    Dr. Gelfand has served as president of the Society of Nuclear Medicine, and served on the board of directors of that organization for 10 years.

    Dr. Gelfand co-edited the textbooks Effective Use of Computers in Nuclear Medicine and Pediatric Nuclear Imaging. His publications include 126 journal articles and 31 book chapters. He has been an invited lecturer or visiting professor in France, Germany, the Netherlands, Italy, Argentina, Brazil, Japan and Australia.

    Education and Training

    BA: University of Michigan, Ann Arbor, MI, 1966. 

    MD: Stanford University, Stanford, CA, 1971. 

    Residency: Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 1973-1975, 1977; Nuclear Medicine, University of Cincinnati, Cincinnati, OH, 1975-1977. 

    Certification: Pediatrics, 1978; Nuclear Medicine, 1978.

    Publications

    View PubMed Publications

    Neurology

    A photo of Mary Sutton.

    Mary Sutton, MD

    513-636-4222

    Mary Sutton, MD

    Assistant Professor, UC Department of Pediatrics

    Phone: 513-636-4222

    Fax: 513-636-3980

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    Specialties

    Neuro-oncology

    Education and Training

    MD: University of Rochester School of Medicine and Dentistry, Rochester, NY, 1989.

    Residency: Pediatrics, Children's Hospital, Boston, MA.

    Fellowship: Neurology, Children's Hospital, Boston, MA.

    Certification: Pediatrics, 1996; Neurology, 1996.

    Physical Medicine and Rehabilitation

    A photo of David Pruitt, MD.

    David W. Pruitt, MD
    Medical Director, Inpatient Pediatric Rehabilitation Unit

    513-636-7480

    david.pruitt@cchmc.org

    David W. Pruitt, MD

    Medical Director, Inpatient Pediatric Rehabilitation Unit

    Director, Pediatric Rehabilitation Medicine Fellowship

    Assistant Professor, UC Department of Pediatrics

    Phone: 513-636-7480

    Fax: 513-636-7360

    Email: david.pruitt@cchmc.org

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    Specialties

    Inpatient pediatric rehabilitation; child and adolescent spinal cord injury; neuro-oncology and musculoskeletal oncology

    Education and Training

    BS: University of Notre Dame, Notre Dame, IN, 1994.

    MD: Loyola University Stritch School of Medicine, Chicago, IL, 1998.

    Residency: Pediatrics, Cincinnati Children's Hospital Medical Center; Physical Medicine and Rehabilitation, University of Cincinnati, Cincinnati, OH.

    Certification: Pediatric Rehabilitation Medicine, 2007; Physical Medicine and Rehabilitation, 2004.

    Publications

    Endocrinology and Fertility

    Susan R. Rose, MD

    Professor, UC Department of Pediatrics

    Phone: 513-636-4744

    Email: susan.rose@cchmc.org

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    Specialties

    Hypothalamic pituitary function; thyroid; disorders of growth or puberty; endocrine function in cancer survivors after head injury

    Education and Training

    MD: Case Western Reserve School of Medicine, 1980.

    MEd: School Psychology, University of Dayton, 1972.

    Residency: The Cleveland Clinic, 1983.

    Fellowship: National Institutes of Health, 1986.

    Certification: Pediatrics, 1985; Pediatric Endocrinology, 1986.

    Publications

    View PubMed Publications

    Grants

    Hypopituitarism in survivors of traumatic brain injury. Primary Investigator. Pfizer Global Pharmaceuticals. 2008 - 2012.

    Meilan M. Rutter, MD

    Assistant Professor, UC Department of Pediatrics

    Phone: 513-636-4744

    Fax: 513-636-7486

    Email: meilan.rutter@cchmc.org

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    Specialties

    Clinical Interests

    Bone health and calcium metabolism; disorders of growth, puberty and sex development; endocrine function in cancer survivors; endocrine function in neuromuscular disorders

    Research Interests

    Insulin-like growth factor-1 (IGF-1) therapy in Duchenne Muscular Dystrophy

    Biography

    Meilan Rutter is board-certified in Pediatrics and Pediatric Endocrinology. She is an Assistant Professor of Pediatrics in the Division of Endocrinology, and joined the faculty of Cincinnati Children's Hospital Medical Center in 2008. Currently, Dr. Rutter is assistant director of the Pediatric Endocrinology Fellowship Program.

    Dr. Rutter received her degrees of Bachelor of Medicine and Bachelor of Surgery (MB, BCh) from the University of Wales College of Medicine. She completed her training in Pediatrics in New Zealand, and was admitted to Fellowship of the Royal Australasian College of Physicians (FRACP) in 1995. She underwent fellowship training in Pediatric Endocrinology at Cincinnati Children's. She completed further pediatric residency training to achieve American Board of Pediatrics specialty and subspecialty board certification.

    Dr. Rutter treats children and adolescents with endocrine disorders and diabetes mellitus. She serves as a consultant for the Neuromuscular Comprehensive Care Center and the Neuro-Oncology program at Cincinnati Children's. Additionally. she is a member of the Disorders of Sex Development interdisciplinary team.

    Education and Training

    MB, BCh: University of Wales College of Medicine, Cardiff, United Kingdom.

    FRACP: Royal Australasian College of Physicians, New Zealand.

    Residency: Auckland Children's Hospital and Dunedin Hospital, New Zealand; Cincinnati Children's, Cincinnati, OH.

    Fellowship: Pediatric Endocrinology, Cincinnati Children's, Cincinnati, OH.

    Certification: General Pediatrics, American Board of Pediatrics, 2002; Pediatric Endocrinology, American Board of Pediatrics, 2003; Pediatrics, Fellowship of the Royal Australasian College of Physicians, 1995.

    Publications

    View PubMed Publications

    Hematopathology

    No photo available

    Richard L. McMasters, MD
    Staff Pathologist

    513-636-4261

    richard.mcmasters@cchmc.org

    No photo available

    Richard L. McMasters, MD

    Staff Pathologist

    Assistant Professor, UC Department of Pediatrics

    Phone: 513-636-4261

    Email: richard.mcmasters@cchmc.org

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    Specialties

    Research Interests

    Dr. McMasters has a research interest in childhood leukemia, lymphoma and bone marrow failure syndromes. His current focus is on applications of flow cytometry in the diagnosis and management of these disorders.

    Clinical Interests

    Dr. McMasters joined Cincinnati Children's in 2008. His main clinical interests are hematopathology and general surgical pathology. He is the laboratory director at Cincinnati Children's Liberty Campus.

    Education and Training

    MD: Baylor College of Medicine, 1994.

    Residency: Harbor-UCLA Medical Center, 2002.

    Fellowships: Children's Hospital Los Angeles, 2003; LAC-USC Medical Center, 2004; Akron Children's Hospital, 2005.

    Certification: Anatomic and Clinical Pathology, 2003; Hematology (Pathology), 2004; Pediatric Pathology, 2005.

    Pain Management and Palliative Care

    A photo of Kenneth R. Goldschneider.

    Kenneth R. Goldschneider, MD, FAAP
    Director, Pain Management Center

    513-636-7768

    kenneth.goldschneider@cchmc.org

    Kenneth R. Goldschneider, MD, FAAP

    Director, Pain Management Center

    Professor, UC Department of Anesthesia

    Phone: 513-636-7768

    Fax: 513-636-2920

    Email: kenneth.goldschneider@cchmc.org

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    Specialties

    Clinical Interests

    Complex chronic pain conditions in infants, children and young adults, including those related to vascular malformations, epidermolysis bullosa and cancer.

    Research Interests

    Outcomes of pain treatment, with a focus on outpatient, chronic pain management.

    Education and Training

    MD: University of Connecticut Health Center School of Medicine, Farmington, CT, 1991. 

    Residency: Pediatrics, Duke University Medical Center, Durham, NC, 1991 - 1994; Anesthesiology, University of Pittsburgh Medical Center, Pittsburgh, PA, 1994-1997. 

    Fellowship: Pediatric Anesthesia, Children's Hospital of Pittsburgh, Pittsburgh, PA, 1997 - 1998; Pain Management, Longwood Combined Pain Fellowship, The Children's Hospital, Boston, MA, 1998 - 1999. 

    Certification: American Board of Pediatrics, 1994; American Board of Anesthesiology, 1998; ABA Pain Management, 2000.

    Publications

    View PubMed Publications
    A photo of Mark Meyer, MD.

    Mark Meyer, MD
    Anesthesiologist

    513-636-4408

    mark.meyer@cchmc.org

    Mark Meyer, MD

    Anesthesiologist

    Assistant Professor, UC Department of Anesthesia

    Phone: 513-636-4408

    Fax: 513-636-2920

    Email: mark.meyer@cchmc.org

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    Specialties

    Clinical Interests

    Palliative medicine; end of life care; anesthesiology; pain management

    Research Interests

    Anesthesia; pain management

    Biography

    Mark Meyer, MD, is a board-certified anesthesiologist who completed his residency at the Cleveland Clinic in Cleveland, Ohio.

    Dr. Meyer joined the Department of Anesthesia in 2003 following his Pediatric Anesthesia Fellowship at Cincinnati Children's Hospital Medical Center.

    Dr. Meyer is a staff anesthesiologist, as well as an attending physician in the Division of Pain Management, caring for patients with acute pain. In addition, Dr. Meyer is an attending physician for StarShine Hospice, the pediatric hospice at Cincinnati Children's.

    In 2006, Dr. Meyer received his board certification from the American Board of Hospice and Palliative Medicine. He has been an integral part of the development and implementation of the Pediatric Palliative and Comfort Care Team / PACT at Cincinnati Children's.

    Dr. Meyer is the PACT consulting physician, partnering with families in order to offer a range of comprehensive, family-centered care for children with chronic, complex or life-threatening conditions.

    Education and Training

    MD: University of Cincinnati College of Medicine, Cincinnati, Ohio, 1998.

    Residency: Cleveland Clinic Foundation, Cleveland, Ohio, 2002.

    Fellowship: Cincinnati Children's Hospital Medical Center, 2003.

    Certification: Anesthesiology, 2004; Hospice and Palliative Medicine, 2006.

    A photo of Norbert Weidner.

    Norbert J. Weidner, MD
    Anesthesiologist

    513-636-4408

    norbert.weidner@cchmc.org

    Norbert J. Weidner, MD

    Anesthesiologist

    Medical Director, StarShine Hospice

    Medical Director, Pediatric Palliative Care / PACT

    Associate Professor, UC Department of Anesthesia

    Phone: 513-636-4408

    Fax: 513-636-2920

    Email: norbert.weidner@cchmc.org

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    Specialties

    Palliative medicine; end of life care; anesthesiology; pain management

    Biography

    Norbert J. Weidner, MD, is a board-certified pediatrician as well as a board-certified anesthesiologist. Following training in pediatrics Cincinnati Children's Hospital Medical Center, as well as Dayton Children's Hospital, he pursued a fellowship in pediatric anesthesia/critical care/regional anesthesia in Melbourne, Australia, for one year.

    Upon completion of his fellowship in 1988, Dr. Weidner joined the Department of Anesthesia at Cincinnati Children's. In addition to his staff duties as an anesthesiologist, Dr. Weidner was an attending staff in the pediatric intensive care unit for approximately two years.

    To incorporate the fellowship training he received in Australia, Dr. Weidner began the pain management group at Cincinnati Children's. He has participated in the pain management group both in the care of acute postoperative pain as well as chronic pain management.

    In 2004, Dr. Weidner received Board Certification with the American Board for Hospice and Palliative Medicine. Dr. Weidner has been affiliated with the hospice service at Cincinnati Children's since its inception and currently serves as StarShine Hospice's Medical Director .

    Dr. Weidner is passionate about partnering with families to offer a range of comprehensive, family-centered care to children with chronic, complex or life-threatening conditions. His vision to address the needs of this patient population resulted in the development of the Pediatric Palliative and Comfort Care Team (PACT) here at Cincinnati Children's. Dr. Weidner serves as the director of this consulting service.

    Education and Training

    MD: Temple Medical School, Philadelphia, PA, 1975.

    Residency: Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 1975-77; Pediatrics, Dayton Children's Hospital, Dayton, OH 1981-82; Anesthesia, University of Cincinnati College of Medicine, Cincinnati, OH, 1985-87.

    Fellowship: Pediatric Anesthesia, Royal Children's Hospital, Melbourne, Australia, 1988.

    Certification: American Board of Anesthesiology, 1983; American Board of Pediatrics, 1989; Diplomat, American Board Medical Acupuncture, 2001; Hospice and Palliative Medicine, 2004.

    Publications

    View PubMed Publications

    Researchers

    A photo of Paul Andreassen.

    Paul R. Andreassen, PhD

    Associate Professor, UC Department of Pediatrics

    Phone: 513-636-0499

    Email: paul.andreassen@cchmc.org

    Show All

    Specialties

    Clinical Interests

    Fanconi Anemia; cell cycle check points; genetic instability; replication stress; relationship of DNA repair and chromatin; mitosis; cell biology

    Visit the Andreassen Lab.

    Education and Training

    BS: Willamette University, Salem, Oregon, 1984

    PhD: University of Washington, Seattle, Washington, 1995

    Publications

    View PubMed Publications

    Grants

    FANCD2 monoubiquitination in DNA damage responses. Principal Investigator. National Heart, Lung, and Blood Institute. Jul 2008 - Jun 2014. #R01 HL085587.
    A photo of Mohammed Azam.

    Mohammad Azam, PhD

    Assistant Professor, UC Department of Pediatrics

    Phone: 513-803-1413

    Email: mohammad.azam@cchmc.org

    Show All

    Specialties

    Clinical Interests

    Leukemia

    Research Interests

    Structure and function analysis of tyrosine kinases involved in the pathogenesis of leukemia; molecular basis of “oncogene addiction”;  modeling of human leukemia in mice using ES and patient derived iPS Cells

    Education and Training

    PhD: Jawaharlal Nehru University, India.

    Post-doc:
    Whitehead Institute for Biomedical Research at MIT (2001-2003).

    Instructor:
    Children’s Hospital of Boston and Harvard Medical School. (2006-2009).

    Publications

    View PubMed Publications

    A photo of Jose Cancelas Perez.

    Jose A. Cancelas Perez, MD, PhD
    Division Director of Research, Hoxworth Blood Center

    513-558-1324

    jose.cancelas@uc.edu

    Jose A. Cancelas Perez, MD, PhD

    Division Director of Research, Hoxworth Blood Center

    Deputy Director, Hoxworth Blood Center

    Director, Research Flow Cytometry Core

    Leader, Stem Cell Program

    Medical Director of Cellular Therapies, Hoxworth Blood Center

    Associate Professor, UC Department of Pediatrics

    Phone: 513-558-1324

    Fax: 513-558-1522

    Email: jose.cancelas@uc.edu

    Show All

    Specialties

    Hematopoietic stem cell proliferation and differentiation

    Visit the Cancelas Lab.

    Education and Training

    MD: Autonomous University of Madrid, Spain, 1989.

    Residency: Hematology and Hematotherapy, University of Alcala de Henares, Madrid, Spain, 1993.

    PhD: Faculty of Medicine, University of Alcala de Henares, Madrid, Spain, 1996.

    Publications

    View PubMed Publications

    Grants

    Progenitor Cell Biology Consortium Administrative Coordinating Center, NHLBI/ Subaward through Univ. Maryland. Co-Director. (Cincinnati Cell Char Core). Sep 2010 – Aug 2016. #U01 HL099997. 

    Rational Design of a Vav/Rac Inhibitor as a New Therapy for High-Risk B-ALL. Principal Investigator. Leukemia & Lymphoma Society of North America. Oct 2012 – Sep 2015. 

    Cincinnati Excellence in Molecular Hematology: Cell Analysis and Sorting Core, NIH/NIDDK. Co-investigator. (Flow Cytometry Core Co-PI).  Sep 2010 – Jun 2015. #P30DK090971-01.

    A photo of Stella Davies.

    Stella M. Davies, MBBS, PhD, MRCP
    Director, Bone Marrow Transplantation and Immune Deficiency

    513-636-2469

    stella.davies@cchmc.org

    Stella M. Davies, MBBS, PhD, MRCP

    Director, Bone Marrow Transplantation and Immune Deficiency

    Jacob G. Schmidlapp Endowed Chair

    Professor, UC Department of Pediatrics

    Phone: 513-636-2469

    Fax: 513-636-3549

    Email: stella.davies@cchmc.org

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    Specialties

    Education and Training

    MBBS: University of Newcastle-Upon-Tyne, England, 1981.

    Clinical and Fellowship Training: The Royal Victoria Infirmary, Newcastle General Hospital and Great Ormond St. Hospital, 1981 to 1985.

    PhD: University of Newcastle-Upon-Tyne, England, 1989.

    Pediatric Fellowship: University of Minnesota, Minneapolis, MN, 1989 to 1993.

    Publications

    View PubMed Publications

    A photo of Hartmut Geiger.

    Hartmut Geiger, PhD
    Director, Mouse Core

    513-636-1338

    hartmut.geiger@cchmc.org

    Hartmut Geiger, PhD

    Director, Mouse Core

    Professor, UC Department of Pediatrics

    Phone: 513-636-1338

    Fax: 513-636-3768

    Email: hartmut.geiger@cchmc.org

    Show All

    Specialties

    Hematopoietic stem cells; genetics; aging/longevity; plasticity of stem cells; mobilization; DNA-repair.

    Education and Training

    MS: Studies in chemistry at the University Karlsruhe, Germany and studies in biochemistry at the University Witten/Herdecke, Germany (1996).

    PhD: Max-Planck Institut für Immunbiologie in Freiburg, Germany.
    Plasticity of murine hematopoietic stem cells (1999).

    Postdoctoral Studies: University of Kentucky, Lexington, USA.
    Genetic analysis of hematopoiesis and aging/longevity in mice.

    Publications

    View PubMed Publications
    A photo of Lee Grimes.

    H. Leighton (Lee) Grimes, PhD
    Director, Cancer Pathology Program of the Division of Experimental Hematology and the Division of Pathology

    513-636-6089

    lee.grimes@cchmc.org

    H. Leighton (Lee) Grimes, PhD

    Director, Cancer Pathology Program of the Division of Experimental Hematology and the Division of Pathology

    Co-Leader, Program in Hematologic Malignancies of Cincinnati Children's Hospital Medical Center, Cancer and Blood Diseases Institute

    Associate Professor, UC Department of Pediatrics

    Phone: 513-636-6089

    Fax: 513-636-5355

    Email: lee.grimes@cchmc.org

    Show All

    Specialties

    Transcriptional control of hematopoiesis and cancer.

    Visit the Grimes Lab.

    Biography

    Grimes Laboratory:

    The cloning and characterization of oncoproteins and tumor suppressors over the last 25 years has not only resulted in a greater understanding of the molecular mechanisms of transformation, but it has also provided a large set of therapeutic targets. Our lab is interested in the progression of a cell with a single genetic lesion to an invasive cancer with multiple genetic alterations. We focus on the Growth factor independence-1 (Gfi1) transcription factor, which is poorly oncogenic alone, but which potently collaborates with well known oncoproteins such as c-MYC. Gfi1 is the most frequently targeted gene in Moloney murine leukemia virus-induced tumors and induces tumor progression to cytokine-independent growth. In contrast, loss of Gfi1 in hematopoietic stem cells induces cell cycle progression and eventual bone marrow failure; implicating Gfi1 as a tumor suppressor in such cells. Gfi1 null mice have no mature neutrophils, and we have identified humans with Severe Congenital Neutropenia (SCN) and Non-Immune Chronic Idiopathic Neutropenia of Adults (NI-CINA) bearing mutations in Gfi1. Interestingly, such patients are at increased risk for the development of myelodysplastic syndromes and acute myeloid leukemia. We have recently generated the first mouse model of Severe Congenital Neutropenia through the expression of mutant Gfi1 proteins in primary murine hematopoietic cells. Moreover, we are utilizing mouse models of human cancer to assess the risk of Gfi1 mutant humans for the development of acute myeloid leukemia.

    Education and Training

    PhD: Immunology and Molecular Pathology, University of Florida, Gainesville, FL.

    Postdoctoral Fellow: Fox Chase Cancer Center.

    Publications

    View PubMed Publications

    Gang Huang, PhD

    Assistant Professor, UC Department of Pediatrics

    Phone: 513-636-3214

    Fax: 513-636-3768

    Email: gang.huang@cchmc.org

    Show All

    Specialties

    Research in Dr. Huang’s laboratory focuses on genetic and epigenetic regulations of blood cell normal development and leukemia. We first demonstrated that AML1/CBFβ (a hetero-dimer transcription factor) and Mixed-Lineage Leukemia (MLL) protein (an enzyme which methylates lysine 4 of histone H3 tails), form a regulatory complex, which is important for normal blood development and acts as a tumor suppressor in leukemia. Mutations in either one of these three genes account for majority of acute myelogenous leukemia (AML), acute lymphoblastic leukemia (ALL) and myelodysplastic syndromes (MDS).

    We also found that the AML1/CBFβ/MLL complex regulates another transcription factor, PU.1, through the upstream regulatory region of the PU.1 gene and that the epigenetic changes of the histone tails occurring in the PU.1 regulatory region correlate with the PU.1 expression level. PU.1 expression level changes are critical for blood cell differentiation and dysregulation of PU.1 dosages leading to leukemia.

    This research will provide new insight into the interplay between genetics and epigenetics in normal blood development and leukemia. It will also help to develop generic drugs for most of the AML, ALL and MDS, which will benefit the future clinical treatments.

    Education and Training

    BS: Peking University, College of Science, Beijing, P.R. China, 1991.

    MS: Inner Mongolia University, Graduate School of Science, Huhhort, P.R. China, 1994.

    PhD: Kyoto University, Graduate School of Medicine, Kyoto, Japan, 2001.

    Publications

    View PubMed Publications

    Ashish R. Kumar, MD, PhD

    Assistant Professor, UC Department of Pediatrics

    Phone: 513-803-1631

    Fax: 513-636-3549

    Email: ashish.kumar@cchmc.org

    Show All

    Specialties

    Clinical Interests

    Childhood cancer and blood disorders; immune deficiency

    Research Interests

    Leukemia biology; cancer biology

    Visit the Kumar Lab.

    Biography

    Dr. Kumar received his medical degree from L.T.M. Medical College, Mumbai, India, his PhD in Anatomy and Cell Biology from the University of Iowa, Pediatric residency training at the Mayo Clinic and fellowship in Pediatric Hematology / Oncology / BMT at the University of Minnesota. He was appointed to the faculty of the University of Minnesota in the Department of Pediatrics where he was a member of the programs in Pediatric Leukemia and Global Pediatrics. As a faculty of the Masonic Cancer Center, he was also part of the Genetic Mechanisms of Cancer research program. Dr. Kumar’s laboratory is engaged in researching the biology of infant leukemia. Discoveries made in his laboratory have significantly enhanced the current understanding of leukemia.

    Education and Training

    MD: LTM Medical College, Mumbai, India.

    Residency: Mayo Clinic, Rochester, MN.

    Fellowship: University of Minnesota, Minneapolis, MN.

    PhD: University of Iowa, Iowa City, IA.

    Certification: General Pediatrics; Pediatric Hematology/Oncology Subspecialty.

    Licenses: State of Ohio; State of Minnesota.

    Publications

    View PubMed Publications

    Grants

    Molecular Pathogenesis of MLL-Fusion Gene Leukemia. View PubMed Publications. Principal Investigator. National Institute of Health. Jul 2007 - Jun 2012.

    Ruhikanta A. Meetei, PhD

    Associate Professor, UC Department of Pediatrics

    Phone: 513-636-1768

    Fax: 513-636-3768

    Email: ruhikanta.meetei@cchmc.org

    Show All

    Specialties

    Clinical Interests

    Fanconi anemia; chromosome instability; DNA repair; multiprotein complex

    Research Interests

    Research in my laboratory focuses on functional analysis of Fanconi anemia gene products. The major research focus includes identification of new FA genes and signal transduction pathways that regulate DNA damage induced activation of the FA-core complex. Important technologies include biochemical purification of multiprotein complexes from human cell extracts, immunoprecipitation, RNAi, and biochemical assays. My long-term research goal is to use Fanconi anemia as a model system to study some of the important fundamental questions of cancer biology in general.

    Education and Training

    BS: Manipur University, India, 1989.

    MS: Manipur University, India, 1992.

    PhD: Indian Institute of Science, Bangalore, India, 2000.

    Publications

    View PubMed Publications

    Grants

    Function and Regulation of FANCM in Fanconi Anemia. National Institutes of Health. May 2007 - Apr 2012. #R01 HL 084082. 

    Functional and Molecular Characterization of Two New Members of the Bloom Syndrome Complex Ohio Cancer Research Associates. Jul 2010 - Jun 2012.

    James C. Mulloy, PhD

    Professor, UC Department of Pediatrics

    Phone: 513-636-1844

    Fax: 513-636-3768

    Email: james.mulloy@cchmc.org

    Show All

    Specialties

    Education and Training

    BA: St. Anselm College, Manchester, New Hampshire, 1986.

    MS: Rutgers University-University of Medicine and Dentistry, New Brunswick, New Jersey, 1989.

    PhD: Rutgers University-University of Medicine and Dentistry, New Brunswick, New Jersey, 1992.

    Publications

    View PubMed Publications

    Grants

    Pediatric Biphenotypic Leukemia. Co-Principal Investigator. Cincinnati Children’s – Sheba Medical Center (Israeli/Mulloy). Nov 2013-Oct 2014.

    Conferring in vivo metabolic resistance to a highly selective anti-AML agent. Co-Investigator. National Institutes of Health R21 NCI (Merino/Mulloy). Apr 2014-Mar 2016.

    Origin and progression of Myelosdysplastic syndrome in patients with Bone Marrow Failure Disorders. Co-Investigator. Center for Clinical and Translational Science and Training (Mehta/Mulloy/Cancelas). Jul 2014-Jun 2015.

    Therapeutic Targeting of LARG-RhoA signaling in childhood leukemia. Co-Principal Investigator. Alex's Lemonade Stand (Zheng/Mulloy). July 2013-June 2015.

    SGN-CD33A anti-tumor activity against relapse AML. Seattle Genetics.  June 2013-May 2014.

    Targeting Cdc42 in leukemia stem cells. Co-Principal Investigator. National Cancer Institute. Apr 2010-Mar 2015. #1R01CA150547-01. 

    Rac Signaling in MLL Leukemia. Principal Investigator. Leukemia and Lymphoma Society. Jul 2010-Jun 2015.

    Cincinnati Center of Excellence in Molecular Hematology. Co-Director, Animal Core. National Institutes of Health. Sep 2010 – Jul 2015. # P30 DK090971.

    Genotype and phenotype of chemoresistant AML. Principal Investigator. NIH, NCI. Mar 13-Feb 15. R21 CA168369

    Hemostatic system components as novel therapeutic targets in childhood AML. Co-Principal Investigator. Center for Clinical and Translational Science and Training (Palumbo/Mulloy). Jul 13-Jun 14.

    A Novel ROS-activated Therapeutic Modality for AML. Co-Principal Investigator. Center for Clinical and Translational Science and Training (Merino/Mulloy). Jul 13-Jun 14.

    Validation and structural requirements of a novel anti-leukemia agent. Co-Principal Investigator. UC Technology Commercialization Accelerator (Merino/Mulloy). University of Cincinnati. Apr 13-Mar 14  

    Efficacy and selectivity in combination of novel ROS activated anticancer agent. Co-Principal Investigator. University Research Council-UC (Merino/Mulloy). Interdisciplinary Faculty Research Support Grant. Apr 13-Mar 14

    Human IFN- Neutralization in Humanized NSGS Mice Developing Cytopenias. Principal Investigator. NovImmune (Mulloy/Jordan). Mar 13-Feb 14.

    LSC mobilization and differentiation therapy. Co-Principal Investigator. Hyundai Hope On Wheels! (Mulloy/Mizukawa). Sep 13-Aug 15.


    Janos Sumegi, MD, PhD

    Professor, UC Department of Pediatrics

    Phone: 513-636-5976

    Fax: 513-636-3549

    Email: janos.sumegi@cchmc.org

    Show All

    Specialties

    Lymphoproliferative disease; hemophagocytic lymphohistiocytosis; usher syndrome

    Education and Training

    MD: University Medical School of Debrecen, Hungary, 1968.

    PhD: Research Center of the Hungarian Academy of Science, Budapest, Hungary, 1974.

    Docent (DMSc): Karolinska Institute Stockhom, Sweden, 1982.

    Publications

    View PubMed Publications

    Grants

    Gene-Expression Profiling of Peripheral Blood Mononuclear Cells in Hemophagocytic Lymphohistiocytosis. Histiocytosis Association of America. Dec 2010 - Nov 2011. 

    No photo available

    David Williams

    Adjunct Professor, Experimental Hematology and Cancer Biology

    Phone: 513-636-0364

    Email: david.williams@cchmc.org

    Show All

    Specialties

    Genetic manipulation of mammalian cells; hematopoietic stem cell biology

    Biography

    Dr. Williams’ major research interests are in the study of blood stem cell biology, blood formation, leukemia and the treatment of genetic blood diseases using gene therapy. He has published over 200 peer-reviewed manuscripts and textbook chapters. He was an investigator of the HHMI for 16 years. He has been continuously funded by the NIH since 1986. His laboratory co-discovered and cloned Interleukin-11 (Neumega™) and carried out developmental studies that assisted in obtaining FDA approval of this drug. His laboratory also described the use of fibronectin in retrovirus-mediated gene transfer, now nearly universally used (as Retronectin®) in clinical gene therapy trials and basic research utilizing gene transfer.

    Dr. Williams basic research has focused on hematopoietic stem cell biology and specifically molecular and biochemical analysis of the interaction between hematopoietic stem cells and the bone marrow supporting environment. This work has recently focused on the roles of Rho GTPases in stem cell engraftment, retention and mobilization from the bone marrow. His laboratory has defined Rac GTPases (Rac1, Rac2 in particular) as key regulatory switches that control stem cell adhesion, migration and survival/proliferation in the adult bone marrow cavity and during fetal development in yolk sac, fetal liver and other embryonic sites. His laboratory has also recently demonstrated that Rac GTPases are essential signaling molecules in BCR-ABL oncogene transformation of hematopoietic stem cells. He and Dr. Yi Zheng (Cincinnati Children’s Hospital) have developed a new small molecule inhibitor of Rac GTPases that is being investigated as a molecular target in cancer therapies. His laboratory is investigating the role of several other Rho GTPases in normal and abnormal hematopoiesis.

    Dr. Williams is currently the Chief, Division of Hematology/Oncology and Director of Clinical and Translational Research, Children’s Hospital Boston and the Leland Fikes Professor of Pediatrics, Harvard Medical School. Dr. Williams is also an adjunct faculty member at Cincinnati Children's.

    Education and Training

    BA: Indiana State University, Terre Haute, IN, 1975.

    MD: Indiana University School of Medicine, Indianapolis, IN, 1979.

    Residency: Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 1979-1982.

    Fellowships: Harvard Medical School, Boston, MA, 1982-1985; The Children's Hospital Boston, Boston, MA, 1982-1985.

    Publications

    View PubMed Publications

    Grants

    Cell Type and Stimulus-Specific Signaling Role of CDC42. National Institutes of Health. Jul 2006 - May 2011.

    Training Program in Cancer Therapeutics. National Cancer Institute. Sep 2006 - Aug 2011.

    Rac GTPases as Targets in Lymphomagenesis. National Institutes of Health. Feb 2007 - Jan 2012.

    Rac proteins in hematoppietic cell survival and function. Prinical Investigator. National Institute of Diabetes and Digestive and Kidney Diseases. Feb 2002 - Jun 2012.

    Rac1 and Rac2 Guanosine Triphosphotase in Erythroid Function and Differentiation. National Heart, Lung and Blood Institute. Feb 2008 - Nov 2012.

    Role of tumor necrosis factor in leukemogenesis. Leukemia & Lymphoma Society. Jul 2008 - Jun 2013.

    Regulation of Systemis RNA Interface in the Nematode C elegans. National Institutes of Health. Jan 2009 - Dec 2013.


    A photo of Yi Zheng.

    Yi Zheng, PhD
    Director, Division of Experimental Hematology and Cancer Biology; Katherine Stewart Waters Endowed Chair

    513-636-0595

    yi.zheng@cchmc.org

    A photo of Yi Zheng.

    Yi Zheng, PhD

    Director, Division of Experimental Hematology and Cancer Biology; Katherine Stewart Waters Endowed Chair

    Co-Director, Cancer and Blood Diseases Institute

    Professor, UC Department of Pediatrics

    Phone: 513-636-0595

    Email: yi.zheng@cchmc.org

    Show All

    Specialties

    Research Interests

    Using transgenic and gene targeted mouse models to study the physiological and pathological roles of Rho GTPases and their regulators in hematopoiesis, neurogenesis, lung cancer development and small intestinal stem cell regulations; mechanism based, rational design of small molecule inhibitors targeting Rho GTPase signaling modules and pathologic functions in cancer and blood diseases; mouse model studies of mTor signaling function in hematopoietic stem cells and small intestinal stem cells.

    Visit the Zheng Lab.

    Education and Training

    BS: Tsinghua University, Beijing, China, 1986.

    MS: Cornell University, Ithaca, NY 1988.

    PhD: Cornell University, Ithaca, NY, 1991.

    Postdoctoral Fellow: Cornell University, Ithaca, NY, 1995.

    Publications

    View All PubMed Publications

    Grants

    Rac GTPase specific small molecule inhibitors. PI: Yi Zheng. National Cancer Institute. NIH - R01 CA141341. 01/01/2000 - 01/31/2014

    Targeting Cdc42 in leukemia stem cells. PI: Yi Zheng, co-PI: James Mulloy. National Cancer Institute - 1R01CA150547-01. 04/01/2010 – 03/31/2015

    Cincinnati Center of Excellence in Molecular Hematology. PI: Yi Zheng. NIDDK - NIH P30 DK090971. 09/30/2010 – 06/30/2015

    Lineage Determination and Tissue Homeostasis in the aged Hematopoietic System. PI: Yi Zheng; co-PI: Hartmut Geiger. NIA - NIH R01AG040118. 08/01/2011 – 07/31/2016

    PHARMACOLOGICAL REJUVENATION OF AGED HEMATOPOIETIC STEM CELLS. PI: Hartmut Geiger; co-PI: Yi Zheng. NIH - NIH R43 AG042986. 08/01/2012 – 07/31/2014

    Targeting Leukemia-associated Rho guanine nucleotide exchange factor LARG in AML. PI: Yi Zheng; co-PI: James Mulloy. Alex’s Lemonade Stand Foundation. 07/01/2013 – 06/30/2015