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The Liver Tumor Program is home to specialists with a wide variety of backgrounds and areas of focus. As a team, this diversity makes us better prepared to care for your child’s unique needs. Learn more about our faculty and staff.
James I. Geller, MD Medical Director, Kidney and Liver Tumors Program 513-636-4266 firstname.lastname@example.org
Medical Director, Kidney and Liver Tumors Program
Co-Medical Director, Retinoblastoma Program
Associate Director, Global Cancer Programs
Associate Professor, UC Department of Pediatrics
Developmental therapeutics; renal / liver / retinoblastoma / neuro-oncology
James I. Geller, MD, completed his undergraduate training at Dartmouth College, graduate medical training at the Sackler School of Medicine, residency training in pediatrics at New York Medical College and pediatric hematology / oncology training at St. Jude Children's Research Hospital. His current appointment is with the University of Cincinnati and Children's Hospital Medical Center in the capacity of associate professor of pediatrics.
Dr. Geller's clinical and academic interests pertain to children and families affected by solid tumors, including brain tumors. Dr. Geller's expertise is recognized both nationally and internationally in the fields of retinoblastoma, renal tumors, liver tumors and brain tumors, as witnessed by his appointments to the Children's Oncology Group (COG) Rare / Retinoblastoma Committee as both a Steering / Voting Member and as liaison to the COG Young Investigator Committee; the COG Renal Tumor Committee (RTC) as Steering/Voting Member, RTC Sub-Committee Chair of Developmental Therapeutics, and RTC liaison to both the COG Developmental Therapeutics Committee and the Pediatric Preclinical Testing Program Guidance Committee; and to the Central Nervous System (Brain Tumor) Committee as a voting member. Dr. Geller has been an invited speaker at numerous national and international meetings and symposia and spearheads both local and national clinical research initiatives in these areas, with an emphasis on finding new treatment options.
MD: Sackler School of Medicine, 1997.
Residency: New York Medical College, 2000.
Fellowship: St Jude Children's Research Hospital, 2004.
Certification: Pediatrics, 2000, 2007; Pediatric Hematology / Oncology, 2005.
Geller JI, Meyers AB, Towbin AJ, Serai S, Geller JI, Podberesky DJ. Characterization of pediatric liver lesions with gadoxetate disodium. Pediatr Radiol. 2011 Sep;41(9):1183-97.
Pressey JG, Wright JM, Geller JI, Joseph DB, Pressey CS, Kelly DR. Sirolimus therapy for fibromatosis and multifocal renal cell carcinoma in a child with tuberous sclerosis complex. Pediatr Blood Cancer. 2010 Jul 1;54(7):1035-7.
Cripe TP. Adenovirus gene therapy for pediatric cancers: shall we gather at the liver? Pediatr Blood Cancer. 2009 Aug;53(2):133-5.
Geller JI, Dome JS. Retroperitoneal lymph node dissection for pediatric renal cell carcinoma. Pediatr Blood Cancer. 2009 Mar;52(3):430.
Geller JI, Leslie ND, Yin H. Malignant Rhabdoid Tumor. eMedicine from WebMD. 2009 Dec. Available online.
Geller JI, Wall D, Perentesis J, Blaney SM, Bernstein M; Pediatric Oncology Group study 9376. Phase I study of paclitaxel with standard dose ifosfamide in children with refractory solid tumors: a Pediatric Oncology Group study (POG 9376). Pediatr Blood Cancer. 2009 Mar;52(3):346-50.
Geller JI. Genetic stratification of Wilms tumor: is WT1 gene analysis ready for prime time? Cancer. 2008 Sep 1;113(5):893-6.
Geller JI, Argani P, Adeniran A, Hampton E, De Marzo A, Hicks J, Collins MH. Translocation renal cell carcinoma: lack of negative impact due to lymph node spread. Cancer. 2008 Apr 1;112(7):1607-16.
Geller JI, Dome JS. Adjuvant therapy in pediatric patients with completely resected renal cell carcinoma. Pediatr Blood Cancer. 2006 Apr;46(4):527.
Geller JI, Dome JS. Local lymph node involvement does not predict poor outcome in pediatric renal cell carcinoma. Cancer. 2004 Oct 1;101(7):1575-83.
Nikolai Timchenko, PhD Head of Liver Tumor Biology, Liver Tumor Program 513-636-0129 email@example.com
Head of Liver Tumor Biology, Liver Tumor Program
Professor, UC Department of Surgery
Nikolai A. Timchenko, PhD, came to Cincinnati Children’s Hospital Medical Center in June of 2014 from Baylor College of Medicine (BCM), where he was a professor of pathology and was working in the Huffington Center on aging.
Dr. Timchenko obtained his PhD in the Institute of Experimental Medicine in St. Petersburg, Russia in the field of liver biology and molecular genetics. After moving to the US, Dr. Timchenko worked at BCM as an assistant professor, associate professor, and full professor until 2014.
He is currently a professor in the Division of General and Thoracic Surgery at Cincinnati Children's. Dr. Timchenko is also the director of the Liver Tumor Program. He investigates mechanisms of liver cancer in children and adults, mechanisms of NAFLD, and mechanisms of age-associated diseases.
Dr. Timchenko is a member of the Digestive Health Center (Cincinnati Children's) and a professor in the Department of Surgery at the University of Cincinnati.
PhD: Institute of Experimental Medicine, St. Petersburg, Russia.
Training: Post-Doc Fellow, Department of Pathology, Baylor College of Medicine, Houston, TX.
Jin J, Hong IH, Lewis K, Iakova P, Breaux M, Jiang Y, Sullivan E, Jawanmardi N, Timchenko L, Timchenko NA. Cooperation of C/EBP family proteins and chromatin remodeling proteins is essential for termination of liver regeneration in mice. Hepatology. 2014.
Hong I, Lewis K, Iakova P, Jin J, Sullivan E, Jawanmardi N, Timchenko L, Timchenko NA. The age-associated change of C/EBP family proteins causes severe liver injury and acceleration of liver proliferation after CCl4-treatments. JBC. 2014;298:1106-1118.
Jin J, Iakova P, Breaux M, Sullivan E, Jawanmardi N, Chen D, Jiang Y, Medrano EE and Timchenko NA. Increased expression of enzymes of triglyceride synthesis plays is essential for the development of hepatic steatosis. Cell Reports. 2013;3:831-843.
Jiang Y, Iakova P, Jin J, Sullivan S, Sharin, V, Hong I-W, Anakk S, Major A, Darlington G, Finegold M, Moore D, Timchenko, NA. FXR inhibits gankyrin in mouse livers and prevents development of liver cancer. Hepatology. 2013;57:1098-1106.
Jones K, Wei C, Iakova P, Bugiardini E, Schneider-Gold Ch, Meola G, Woodgett G, Killian J, Timchenko NA, Timchenko LT. GSK3beta is a key determinant of muscle pathology in DM1. J Clin Invest. 2012;122:4461-4472.
Jones K, Timchenko L, Timchenko NA. The role of CUGBP1 in age-dependent changes of liver functions. Aging Research Reviews 11. 2012;442-449.
Jin J, Iakova P, Jiang J, Medrano EE, Timchenko NA. The reduction of SIRT1 in livers of old mice leads to impaired body homeostasis and to inhibition of liver proliferation. Hepatology. 2011;54:898-998.
Iakova P, Timchenko LT, Timchenko NA. Intracellular signaling and hepatocellular carcinoma. Seminars in Cancer Biology. 2011;21:28-34.
Jin J, Iakova P, Wang G-l, Shi X, Haefliger S, Finegold M, Timchenko NA. Epigenetic changes play critical role in age-associated dysfunction of the liver. Aging Cell. 2010;9:895-910.
Wang G-L, Shi X, Haefliger S, Jin J, Major A, Iakova P, Finegold M, Timchenko NA. Elimination of C/EBP through the ubiquitin-proteasome system promotes the development of liver cancer in mice. J. Clin. Invest. 2010;120:2549-2562.
Denise M. Adams, MD Marjory J. Johnson Chair of Vascular Tumor Translational Research 513-636-4266 firstname.lastname@example.org
Marjory J. Johnson Chair of Vascular Tumor Translational Research
Medical Director, Hemangioma and Vascular Malformation Program
Fellowship Director, Hematology / Oncology
Professor, UC Department of Pediatrics
Quarmyne MO, Gupta A, Adams DM. Lymphangiosarcoma of the thorax and thoracic vertebrae in a 16-year-old girl. J Clin Oncol. 2012 Oct;30(29):294-8.
Haggstrom AN, Beaumont JL, Lai JS, Adams, DM, Drolet BA, Frieden IJ, Garzon MC, Holland KE, Horii KA, Lucky AW, Mancini AJ, Metry DW, Morel KD, Newell BD, Nopper AJ, Siegel D, Swigonski NL, Cella D, Chamlin SL. Measuring the severity of infantile hemangiomas: instrument development and reliability. Arch Dermatol. 2012 Feb;148(2):197-202.
Fadell MF 2nd, Jones BV, Adams DM. Prenatal diagnosis and postnatal follow-up of rapidly involuting congenital hemangioma (RICH). Pediatr Radiol. 2011 Aug;41(8):1057-60.
Maugans T, Sheridan RM, Adams D, Gupta A. Cutaneous vascular anomalies associated with neural tube defects: nomenclature and pathology revisited. Neurosurgery. 2011 Jul;69(1):112-8.
Hammill AM, Wentzel M, Gupta A, Nelson S, Lucky A, Elluru R, Dasgupta R, Azizkhan RG, Adams DM. Sirolimus for the treatment of complicated vascular anomalies in children. Pediatr Blood Cancer. 2011 Dec 1;57(6):1018-24.
Adams DM. Special considerations in vascular anomalies: hematologic management. Clin Plast Surg. 2011 Jan;38(1):153-60.
Duffy KJ, Runge-Samuelson C, Bayer ML, Friedland D, Sulman C, Chun R, Kerschner JE, Metry D, Adams D, Drolet BA. Association of hearing loss with PHACE syndrome. Arch Dermatol. 2010 Dec;146(12):1391-6. Drolet BA, Chamlin SL, Garzon MC, Adams D, Baselga E, Haggstrom AN, Holland KE, Horii KA, Juern A, Lucky AW, Mancini AJ, McCuaig C, Metry DW, Morel KD, Newell BD, Nopper AJ, Powell J, Frieden IJ. Prospective study of spinal anomalies in children with infantile hemangiomas of the lumbosacral skin. J Pediatr. 2010 Nov;157(5):789-94.
Lomenick JP, Reifschneider KL, Lucky AW, Adams D, Azizkhan RG, Woo JG, Backeljauw PF. Prevalence of adrenal insufficiency following systemic glucocorticoid therapy in infants with hemangiomas. Arch Dermatol. 2009 Mar;145(3):262-6.
Dickie B, Dasgupta R, Nair R, Alonso MH, Ryckman FC, Tiao GM, Adams DM, Azizkhan RG. Spectrum of hepatic hemangiomas: management and outcome. J Pediatr Surg. 2009 Jan;44(1):125-33.
John C. Bucuvalas, MD Associate Medical Director, Pediatric Liver Care Center 513-636-4415 email@example.com
Associate Medical Director, Pediatric Liver Care Center
Liver disease; transplantation; outcomes research; improving the quality of health care delivery.
Visit the Bucuvalas Lab.
John Bucuvalas, MD, came to Cincinnati Children's Hospital Medical Center in 1982 as a fellow in gastroenterology. He joined the faculty in 1986. He graduated from Harvard College in 1974 and Harvard Medical School in 1978. He completed a pediatric residency at Massachusetts General Hospital and served there as chief resident from 1981 to 1982.
Over the last 10 years, the focus his patient care and research efforts have been outcomes research and improving the care delivery system for children with chronic liver disease who then may undergo liver transplantation. He has focused on integration of research into patient care and improving the care delivery system. Along the way, he has gained significant content knowledge through traditional research but additionally have learned how to improve processes, understand the system that is academic medicine, interpret variation and recognize the role of leadership both for research and clinical efforts. Dr. Bucuvalas has made significant contributions in the clinical and research arenas towards improving care, enhancing the delivery care and optimizing the outcome of children with chronic liver disease and pediatric liver transplant recipients.
Dr. Bucuvalas has been recognized as a leader in the field of pediatric hepatology and liver transplantation at a local, regional and national level.
AB: Harvard College, Cambridge, MA, 1974.
MD: Harvard Medical School, Boston, MA, 1978.
Residency: Pediatrics, Massachusetts General Hospital, Boston, MA, 1978 to 1981.
Chief Residency: Pediatrics, Massachusetts General Hospital, Boston, MA, 1981 to 1982.
Fellowship: Gastroenterology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 1982 to 85.
Research Scholar: Gastroenterology, Children's Hospital Research Foundation, Cincinnati, OH, 1985 to 86.
Certification: Pediatrics, 1983; Pediatric Gastroenterology, 1990; recertified, 1997, 2004.
Campbell K, Ng V, Martin S, Magee J, Goebel J, Anand R, Martz K, Bucuvalas J; SPLIT Renal Function Working Group. Glomerular filtration rate following pediatric liver transplantation--the SPLIT experience. Am J Transplant. 2010 Dec;10(12):2673-82.
Campbell KM, Bucuvalas JC. Renal function in the long term after pediatric liver transplantation: is there a need for protocol kidney biopsies? Curr Opin Organ Transplant. 2010 Oct;15(5):608-13.
Bucuvalas J. Long-term outcomes in pediatric liver transplantation. Liver Transpl. 2009 Nov;15 Suppl 2:S6-11.
Bucuvalas JC, Anand R; Studies of Pediatric Liver Transplantation Research Group. Treatment with immunoglobulin improves outcome for pediatric liver transplant recipients. Liver Transpl. 2009 Nov;15(11):1564-9.
Bucuvalas JC, Alonso E, Magee JC, Talwalkar J, Hanto D, Doo E. Improving long-term outcomes after liver transplantation in children. Am J Transplant. 2008 Dec;8(12):2506-13.
Bucuvalas JC, Alonso E. Long-term outcomes after liver transplantation in children. Curr Opin Organ Transplant. 2008 Jun;13(3):247-51. Review.
Ryckman FC, Bucuvalas JC, Nathan J, Alonso M, Tiao G, Balistreri WF. Outcomes following liver transplantation. Semin Pediatr Surg. 2008 May;17(2):123-30.
Bucuvalas JC, Campbell KM, Cole CR, Guthery SL. Outcomes after liver transplantation: keep the end in mind. J Pediatr Gastroenterol Nutr. 2006 Jul;43 Suppl 1:S41-8.
Campbell KM, Yazigi N, Ryckman FC, Alonso M, Tiao G, Balistreri WF, Atherton H, Bucuvalas JC. High prevalence of renal dysfunction in long-term survivors after pediatric liver transplantation J Pediatr. 2006 Apr;148(4):475-80.
Xanthakos S, Miles L, Bucuvalas J, Daniels S, Garcia V, Inge T. Histologic spectrum of nonalcoholic fatty liver disease in morbidly obese adolescents. Clin Gastroenterol Hepatol. 2006 Feb;4(2):226-32.
Kathleen M. Campbell, MD 513-636-4415 firstname.lastname@example.org
Diagnosis and management of pediatric liver disease, particularly biliary atresia and other forms of neonatal cholestasis; liver transplantation and post-transplant renal dysfunction.
Kathleen M. Campbell, MD, joined the Division of Gastroenterology, Hepatology and Nutrition as a fellow in 2000, after completing her pediatric residency training at Cincinnati Children's Hospital Medical Center. Following the completion of her fellowship, she pursued an additional year of training in Pediatric Hepatology under the mentoring of Dr. William Balistreri and the physicians and surgeons of the Pediatric Liver Care Center, becoming one of the first in her specialty to obtain focused training in this field.
In 2004, Dr. Campbell was appointed assistant professor of pediatrics in the Division of Gastroenterology, Hepatology and Nutrition and the Pediatric Liver Care Center. Her clinical and translational research interests include post-transplant renal dysfunction and genetic modifiers of disease in biliary atresia.
MD: University of Tennessee College of Medicine, Memphis, TN, 1997.
Residency: Pediatrics, University of Cincinnati and Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2000.
Fellowship: Pediatric Gastroenterology, Hepatology and Nutrition, University of Cincinnati and Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2003.
Advanced Fellowship: Pediatric Hepatology, University of Cincinnati and Cincinnati Children's Hospital Medical Center, 2004.
Certification: Pediatrics, 2000; Pediatric Gastroenterology, Hepatology and Nutrition, 2003.
Choquette M, Goebel JW, Campbell KM. Nonimmune complications after transplantation. Pediatr Clin North Am. 2010 Apr;57(2):505-21, table of contents. Review.
Pacheco MC, Campbell KM, Bove KE. Ductal plate malformation-like arrays in early explants after a Kasai procedure are independent of splenic malformation complex (heterotaxy). Pediatr Dev Pathol. 2009 Sep-Oct;12(5):355-60.
Calvo-Garcia MA, Campbell KM, O'Hara SM, Khoury P, Mitsnefes MM, Strife CF. Acquired renal cysts after pediatric liver transplantation: association with cyclosporine and renal dysfunction. Pediatr Transplant. 2008 Sep;12(6):666-71.
Campbell KM, Arya G, Ryckman FC, Alonso M, Tiao G, Balistreri WF, Bezerra JA. High prevalence of alpha-1-antitrypsin heterozygosity in children with chronic liver disease. J Pediatr Gastroenterol Nutr. 2007 Jan;44(1):99-103.
Campbell KM, Yazigi N, Ryckman FC, Alonso M, Tiao G, Balistreri WF, Atherton H, Bucuvalas JC. High prevalence of renal dysfunction in long-term survivors after pediatric liver transplantation. J Pediatr. 2006 Apr;148(4):475-80.
Shivakumar P, Campbell KM, Sabla GE, Miethke A, Tiao G, McNeal MM, Ward RL, Bezerra JA. Obstruction of extrahepatic bile ducts by lymphocytes is regulated by IFN-gamma in experimental biliary atresia. J Clin Invest. 2004 Aug;114(3):322-9.
Campbell KM, Sabla GE, Bezerra JA. Transcriptional reprogramming in murine liver defines the physiologic consequences of biliary obstruction. J Hepatol. 2004 Jan;40(1):14-23.
Campbell KM and Balistreri WF. Inflammatory Bowel Disease. Comprehensive Pediatrics. 1st edition. 2001.
Rohit Kohli, MBBS, MS Associate Medical Director, Liver Transplant Program 513-803-7044 email@example.com
Associate Medical Director, Liver Transplant Program
Co-Director, Steatohepatitis Center
Attending Physician, Liver Care Center
Non-alcoholic steatohepatitis; liver transplantation; mitochondrial hepatopathies
Rohit Kohli, MBBS, MS, is currently an associate professor of pediatrics at the University of Cincinnati College of Medicine and the co-director of the Cincinnati Children's Steatohepatitis Center.
Dr. Kohli received his medical degree from the Armed Forces Medical College, India in 1999 and his MS in clinical investigation from Northwestern University in 2006. While at Northwestern he first spent three years as a pediatric gastroenterology and hepatology fellow and then subsequently as a transplant hepatology trainee before relocating to the University of Cincinnati in 2007.
His research work has focused on the pathogenesis of obesity related fatty liver disease (NAFLD). In particular, he has focused upon the role of reactive oxygen stress in the generation and regulation of the extreme stage of this disease; nonalcoholic steatohepatitis (NASH). Dr. Kohli's laboratory currently focuses on the role of fructose in triggering above mentioned oxidative injury and fibrosis within the liver. He also works with Drs. Randy Seeley and Stephen Woods at the Metabolic Diseases Institute at the University of Cincinnati to understand the mechanism and impact of bariatric surgical procedures on NASH and other co-morbidities of obesity.
He has published many peer-reviewed articles including articles in The Journal of Biological Chemistry, Hepatology, Journal of Pediatrics, and The American Journal of Physiology. He is the author of many book chapters and review articles. He also is the recipient of the 2007 George Ferry Young Investigator Award from the Children's Digestive Health and Nutrition Foundation and a Fellowship award from the American Association for the Study of Liver Diseases. His clinical efforts are focused within the Steatohepatitis Center and Liver Care Center in the Division of Gastroenterology, Hepatology and Nutrition at Cincinnati Children's Hospital Medical Center.
MS: Clinical Investigation, School of Public Health, Northwestern University, IL, 2004-2006.
MBBS: Armed Forces Medical College, Pune University, India,1993-1999.
Residency: Metropolitan Hospital, New York Medical College, NY, 2000-2003.
Fellowship: Gastroenterology, Children's Memorial Hospital, Northwestern University, IL, 2003-2006.
Fellowship: Transplant Hepatology, Children's Memorial Hospital, Northwestern University, IL, 2006-2007.
Certification: Pediatrics, 2004; Transplant Hepatology, 2010; Gastroenterology, 2009.
Carter-Kent C, Brunt EM, Yerian LM, Alkhouri N, Angulo P, Kohli R, Ling SC, Xanthakos SA, Whitington PF, Charatcharoenwitthaya P, Yap J, Lopez R, McCullough AJ, Feldstein AE. Relations of Steatosis Type, Grade, and Zonality to Histological Features in Pediatric Nonalcoholic Fatty Liver Disease. J Pediatr Gastroenterol Nutr. 2011 Feb;52(2):190-197.
Kohli R. Indian Childhood Cirrhosis- Revisited. J of Pediatr. 2010 Nov;157:766.
Kohli R, Kirby M, Xanthakos SA, Softic S, Feldstein AE, Saxena V, Tang PH, Miles L, Miles MV, Balistreri WF, Woods SC, Seeley RJ. High-fructose, medium chain trans fat diet induces liver fibrosis and elevates plasma coenzyme Q9 in a novel murine model of obesity and nonalcoholic steatohepatitis. Hepatology. 2010 Sep;52(3):934-44.
Kohli R, Kirby M, Setchell KD, Jha P, Klustaitis K, Woollett LA, Pfluger PT, Balistreri WF, Tso P, Jandacek RJ, Woods SC, Heubi JE, Tschoep MH, D'Alessio DA, Shroyer NF, Seeley RJ. Intestinal adaptation after ileal interposition surgery increases bile acid recycling and protects against obesity-related comorbidities. Am J Physiol Gastrointest Liver Physiol. 2010 Sep;299(3):G652-60.
Kohli R, Boyd T, Lake K, Dietrich K, Nicholas L, Balistreri WF, Ebach D, Shashidhar H, Xanthakos SA. Rapid progression of NASH in childhood. J Pediatr Gastroenterol Nutr. 2010 Apr;50(4):453-6.
Carter-Kent C, Brunt EM, Xanthakos SA, Kohli R, Whitington PF, Angulo P, Feldstein AE. Nonalcoholic steatohepatitis in children: a multicenter clinicopathological study. Hepatology. 2009 Oct; 50(4):1113-20.
Kohli R, Ramsingh H, Makkad B. The anesthetic management of ocular trauma. Int Anesthesiol Clin. 2007 Summer;45(3):83-98. Review.
Kohli R, Pan X, Malladi P, Wainwright MS, Whitington PF. Mitochondrial reactive oxygen species signal hepatocyte steatosis by regulating the PI 3-kinase cell survival pathway. Journal of Biological Chemistry. 2007 Jul 20;282(29):21327-36.
Sahai A, Pan X, Paul R, Malladi P, Kohli R, Whitington PF. Roles of phosphatidylinositol 3-kinase and osteopontin in steatosis and aminotransferase release by hepatocytes treated with methionine-choline deficient medium. American Journal of Physiology. 2006 Jul; 291(1): G55-62.
Kohli R, Alonso EM, Whitington PF. Liver Transplantation: The Recipient: Long-term Outcome: Pediatric Recipient. In Living Donor Organ Transplantation, Gruessner RWG, Benedetti E (Eds). New York: McGraw Hill, 2008.
Mike A. Leonis, MD, PhD 513-636-4415 firstname.lastname@example.org
MD: Washington University School of Medicine, St. Louis, MO, 1996.
PhD: Washington University School of Medicine, St. Louis, MO, 1996.
Procter Scholar: Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2002-2005.
Fellowship: Cincinnati Children's, Cincinnati, OH, 1999-2002.
Residency: Primary Children's Hospital Medical Center, University of Utah School of Medicine, Salt Lake City, UT, 1996-1999.
Certification: American Board of Pediatrics, 1999; Pediatric Gastroenterology, Hepatology and Nutrition, 2003.
Stuart WD, Kulkarni RM, Gray JK, Vasiliauskas J, Leonis MA, Waltz SE. Ron receptor regulates Kupffer cell-dependent cytokine production and hepatocyte survival following endotoxin exposure in mice. Hepatology. 2011 May;53(5):1618-28.
Kenny AP, Crimmins NA, Mackay DJ, Hopkin RJ, Bove KE, Leonis MA. Concurrent course of transient neonatal diabetes with cholestasis and paucity of interlobular bile ducts: a case report. Pediatr Dev Pathol. 2009 Sep-Oct;12(5):417-20.
Leonis MA, Balistreri WF. Evaluation and management of end-stage liver disease in children. Gastroenterology. 2008 May;134(6):1741-51.
Caldwell CC, Martignoni A, Leonis MA, Ondiveeran HK, Fox-Robichaud AE, Waltz SE. Ron receptor tyrosine kinase-dependent hepatic neutrophil recruitment and survival benefit in a murine model of bacterial peritonitis. Crit Care Med. 2008 May;36(5):1585-93.
Leonis MA, Thobe MN, Waltz SE. Ron-receptor tyrosine kinase in tumorigenesis and metastasis. Future Oncol. 2007 Aug;3(4):441-8. Review.
Zinser GM, Leonis MA, Toney K, Pathrose P, Thobe M, Kader SA, Peace BE, Beauman SR, Collins MH, Waltz SE. Mammary-specific Ron receptor overexpression induces highly metastatic mammary tumors associated with beta-catenin activation. Cancer Res. 2006 Dec 15;66(24):11967-74.
Wetzel CC, Leonis MA, Dent A, Olson MA, Longmeier AM, Ney PA, Boivin GP, Kader SA, Caldwell CC, Degen SJ, Waltz SE. Short-form Ron receptor is required for normal IFN-gamma production in concanavalin A-induced acute liver injury. Am J Physiol Gastrointest Liver Physiol. 2007 Jan;292(1):G253-61.
Leonis MA, Toney-Earley K, Degen SJ, Waltz SE. Deletion of the Ron receptor tyrosine kinase domain in mice provides protection from endotoxin-induced acute liver failure. Hepatology. 2002 Nov;36(5):1053-60.
Maria H. Alonso, MD Surgical Director, Kidney Transplant Program 513-636-4371 email@example.com
Surgical Director, Kidney Transplant Program
Co-Surgical Director, Intestinal Transplant Surgery
Associate Professor, UC Department of Surgery
Liver, kidney transplantation; hepatobiliary surgery; minimally invasive surgery; trauma
MD: University of Pennsylvania School of Medicine, Philadelphia, PA, 1982.
Residency: Surgery, Eastern Virginia Graduate School of Medicine, Norfolk, VA.
Fellowship: Trauma / Critical Care, Maryland Institute for Emergency Medical Services Systems, Baltimore, MD; Trauma / Burn, Children's National Medical Center, Washington, D.C.; Pediatric Surgery, Children's Mercy Hospital, Kansas City, MO; Transplantation, University of Cincinnati College of Medicine, Cincinnati, OH.
Certification: Surgery, 1999; Pediatric Surgery, 2001; Surgical Critical Care, 2001.
Jaimie D. Nathan, MD Surgical Director, Intestinal Transplant Program 513-636-4371 firstname.lastname@example.org
Surgical Director, Intestinal Transplant Program
Surgical Director, Pancreas Care Center
Assistant Professor, UC Department of Surgery
UC Department of Pediatrics
Hepatobiliary and pancreatic disease; liver, kidney, and intestinal transplantation; pediatric surgical oncology; neonatal surgery; minimally invasive surgery
BS: Yale University, New Haven, CT, 1993.
MD: Yale University, New Haven, CT, 1998.
Residency: General Surgery, Duke University Medical Center, Durham, NC, 1998-2000 and 2002-2005.
Surgical Research Fellowship: Duke University Medical Center, Durham, NC, 2000-2002.
Pediatric Surgery Fellowship: Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2005-2007.
Transplant Surgery Fellowship: University of Cincinnati, Cincinnati, OH, 2007-2009.
Certification: American Board of Surgery, General Surgery, 2007; American Board of Surgery, Pediatric Surgery, 2008; American Society of Transplant Surgeons Certification, 2009.
Prada CE, Kaul A, Hopkin RJ, Page KI, Nathan JD, Bartholomew DW, Cohen MB, Heubi JE, Leslie ND, Burrow TA. Recurrent pancreatitis in ornithine transcarbamylase deficiency. Mol Genet Metab. 2012 Aug;106(4):482-484.
Bondoc AJ, Taylor JA, Alonso MH, Nathan JD, Wang Y, Balistreri WF, Bezerra JA, Ryckman FC, Tiao GM. The beneficial impact of revision of Kasai portoenterostomy for biliary atresia: an institutional study. Ann Surg. 2012 Mar;255(3):570-576.
Shin CR, Nathan J, Alonso M, Yazigi N, Kocoshis S, Tiao G, Davies SM. Incidence of acute and chronic graft-versus-host disease and donor T-cell chimerism after small bowel or combined organ transplantation. J Pediatr Surg. 2011 Sep;46(9):1732-1738.
Vigna SR, Shahid RA, Nathan JD, McVey DC, Liddle RA. Leukotriene B4 mediates inflammation via TRPV1 in duct obstruction-induced pancreatitis in rats. Pancreas. 2011 Jul;40(5):708-714.
Nathan JD, Romac J, Peng RY, Peyton M, Rockey DC, Liddle RA. Protection against chronic pancreatitis and pancreatic fibrosis in mice overexpressing pancreatic secretory trypsin inhibitor. Pancreas. 2010 Jan;39(1):e24-30.
Follmar KE, Condron SA, Turner II, Nathan JD, Ludwig KA. Treatment of metronidazole-refractory Clostridium difficile enteritis with vancomycin. Surg Infect. 2008 9:195-200.
Nathan JD, Rudolph JA, Kocoshis SA, Alonso MH, Ryckman FC, Tiao GM. Isolated liver and multivisceral transplantation for total parenteral nutrition-related end-stage liver disease. J Pediatr Surg. 2007 Jan;42(1):143-7.
Patel MB, Nathan JD, Frush DP, Rice HE. Nonoperative management of asymptomatic traumatic pulmonary hernia in a young child. J Trauma. 2007 62:234-235.
Nathan JD, Romac J, Peng RY, Peyton M, MacDonald RJ, Liddle RA. Transgenic expression of pancreatic secretory trypsin inhibitor-I ameliorates secretagogue-induced pancreatitis in mice. Gastroenterology. 2005 128:717-727.
Frederick C. Ryckman, MD Sr. Vice President, Medical Operations 513-636-4371 email@example.com
Sr. Vice President, Medical Operations
UC Department of Surgery
Transplantation; liver; kidney transplantation; small intestine; biliary disease; Extracorporeal membrane oxygenation (ECMO); minimally invasive surgery; chest wall abnormalities
Frederick C. Ryckman, MD, is clinical director of the Pediatric General and Thoracic Surgery Division.
Dr. Ryckman is also vice president of System Capacity & Perioperative Operations.
Dr. Ryckman is also a pediatric surgeon at the Cincinnati Fetal Center.
BS: Lyman Briggs College of Science and Mathematics, Michigan State University, East Lansing, MI, 1969 to 1973.
MD: University of Michigan Medical School, Ann Arbor, MI, 1977.
Residency: University of Florida Medical Center, Gainesville, FL, 1977 to 1982.
Fellowship: Pediatric Surgery, Children's Hospital Medical Center, Cincinnati, OH, 1982 to 1984.
Certification: National Board of Medical Examiners, 1977; American Board of Surgery, 1983; recertification, 1993; Certificate of Special Competence in Pediatric Surgery, 1986; recertification, 1993.
Wagner LM, Gelfand MJ, Laor T, Ryckman FC, Al-Ghawi H, Bove KE. A Welcome Surprise: Nodular Fasciitis Presenting as Soft Tissue Sarcoma. J Pediatr Hematol Oncol. 2010 Oct 21.
Taylor JA, Ryckman FC. Management of small bowel volvulus around feeding Roux-en-Y limbs. Pediatr Surg Int. 2010 Apr;26(4):439-42.
Ryckman FC, Yelton PA, Anneken AM, Kiessling PE, Schoettker PJ, Kotagal UR. Redesigning intensive care unit flow using variability management to improve access and safety. Jt Comm J Qual Patient Saf. 2009 Nov;35(11):535-43.
Rattan AS, Laor T, Ryckman FC, Brody AS. Pectus excavatum imaging: enough but not too much. Pediatr Radiol. 2010 Feb;40(2):168-72.
Propst EJ, Lin EP, Istaphanous GK, Boesch RP, Ryckman FC, Cotton RT, Rutter MJ. Management of traumatic tracheobronchial separation in a teenager using a fabricated extra-long endotracheal tube. Int J Pediatr Otorhinolaryngol. 2009 Aug;73(8):1163-7.
Ryckman FC, Schoettker PJ, Hays KR, Connelly BL, Blacklidge RL, Bedinghaus CA, Sorter ML, Friend LC, Kotagal UR. Reducing surgical site infections at a pediatric academic medical center. Jt Comm J Qual Patient Saf. 2009 Apr;35(4):192-8.
Sparling KW, Ryckman FC, Schoettker PJ, Byczkowski TL, Helpling A, Mandel K, Panchanathan A, Kotagal UR. Financial impact of failing to prevent surgical site infections. Qual Manag Health Care. 2007 Jul-Sep;16(3):219-25.
Nathan JD, Rudolph JA, Kocoshis SA, Alonso MH, Ryckman FC, Tiao GM. Isolated liver and multivisceral transplantation for total parenteral nutrition-related end-stage liver disease. J Pediatr Surg. 2007 Jan;42(1):143-7.
Greg M. Tiao, MD Richard and Geralyn Azizkhan Chair in Pediatric Surgery 513-636-4371 firstname.lastname@example.org
Richard and Geralyn Azizkhan Chair in Pediatric Surgery
Surgical Director, Liver Transplantation
Associate Director, Pediatric Surgery Fellowship
As a pediatric surgeon and a transplant surgeon, Dr. Tiao is involved in the care of children afflicted with biliary atresia from the time of presentation and diagnosis to the initial Kasai portoenterostomy to the liver transplant, when necessary. He sees the many challenges children and their families experience when diagnosed with this life threatening disease process. From that perspective, defining the basis of this disease process such that therapeutic strategies can be developed eliminating these complex interventions is his career goal. His short term goal is to develop an independent research laboratory investigating the pathogenesis of virus induced biliary atresia specifically seeking to determine the mechanistic basis of this disease so that new treatment strategies can be developed to salvage the native liver.
Dr. Tiao's overarching hypothesis is that biliary atresia results from the infection of cholangiocytes by a virus triggering immune-mediated biliary obstruction. His focus is to determine the mechanisms used by RRV to infect cholangiocytes, how RRV undergoes replication within the cholangiocyte, and how infected cholangiocytes modify the microenvironment, activating the immune system resulting in biliary obstruction. Determination of the mechanistic basis of these inter-related events is essential to understanding the pathogenesis of virus induced BA. By focusing on the basis for the viral insult in the initiation of biliary atresia, he has defined an area of independence from Dr Jorge Bezerra, his primary research mentor.
BS: Northwestern University, Evanston, IL, 1986.
MD: University of Illinois, Chicago, IL, 1990.
Residency: Loyola University, Maywood, IL, 1991-1992; Senior Resident, Department of Surgery, University of Cincinnati, Cincinnati, OH, 1995-1997;Chief Resident, Department of Surgery, University of Cincinnati, Cincinnati, OH, 1997-1998.
Fellowships: Research Fellow, University of Cincinnati, Cincinnati, OH, 1992-1995; Transplant Surgery Fellow, University of Cincinnati, Cincinnati, OH, 2000-2002;Pediatric Surgery Fellow, Los Angeles Children's Hospital, Los Angeles, CA, 1998-2000.
Certification: Pediatric Surgeon, 2000; Transplant Surgeon, 2002.
Coots A, Donnelly B, Mohanty S, Tiao G. Rotavirus Infection of Human Cholangiocytes Parallels the Murine Model of Biliary Atresia. J Surg Res. 2012 Oct;177(2):275-81. 2012.
Meyers RL, Tiao GM, Dunn SP, Langham Jr, MR. Liver transplantation in the management of unresectable hepatoblastoma in children. Front Biosci (Elite Ed). 2012 Jan;E4:1293-302.
Shin CR, Nathan J, Alonso M, Yazigi N, Kocoshis S, Tiao G, Davies SM. Incidence of acute and chronic graft-versus-host disease and donor T-cell chimerism after small bowel or combined organ transplantation. J Pediatr Surg. 2011;46:1732-8.
Fernandez KS, Baum R, Fung B, Yeager N, Leonis MA, Wagner LM, Tiao G, Ross ME. Chemoresistant Hepatoblastoma in a Patient with Mosaic Trisomy 18 Treated with Orthotopic Liver Transplantation. Peditr Blood Cancer. 2011;56:498-500.
Superina R, Magee J, Brandt M, Healey P, Tiao G, Ryckman F, Karrer F, Iyer K, Fecteau A, West K, Burns R, Flake A, Hammin L, Lowell J, Dillon P, Columbani P, Ricketts R, Yun L, Moore J, Kasper W. Childhood Liver Research and Education Network. AnnSurg. 2011.
Bondoc A, Taylor J, Alonso M, Nathan, J, Wang Y, Balistreri W, Bezerra J, Ryckman F, Tiao G. The Beneficial Impact of Revision of Kasai Portoenterostomy for Biliary Atresia: An Institutional Study. AnnSurg. 2012;255(3):570-6.
Wang W, Donnelly B, Bondoc A, Mohanty SK, McNeal M, Ward R, Sestak K, Zheng S, Tiao G. The rhesus rotavirus gene encoding VP4 is a major determinant in the pathogenesis of biliary atresia in newborn mice. J Virol. 2011 Sep;85(17):9069-77.
Jafri M, Donnelly B, Bondoc A, Allen S, Tiao G. Cholangiocyte secretion of chemokines in experimental biliary atresia. J Pediatr Surg. 2009;44(3):500-7.
Bondoc AJ, Jafri MA, Donnelly B, Mohanty SK, McNeal MM, Ward, RL, Tiao GM. Prevention of the murine model of biliary atresia after live rotavirus vaccination of dams. J Pediatr Surg. 2009;44(8):1479-90.
The Molecular Determinants of Virus Induced Biliary Induced Biliary Asteria. Principal Investigator. Apr 2011 - Mar 2016.
Nycomed Liver Trial. Principal Investigator. 2012-present.TC-2402-040-SP.
Kevin E. Bove, MD 513-636-4261 email@example.com
UC Department of Pathology & Laboratory Medicine
Dr. Bove's current research focus is on pathogenesis of biliary atresia and other cholestatic disorders of infancy. He has long term research interests in the early stages of childhood neoplasia and childhood diseases of skeletal muscle and heart.
Dr. Bove has been a career academic pediatric pathologist at Cincinnati Children's since 1968. He functions as a surgical pathologist, autopsy consultant and electron microscopist with diverse clinical interests. His collaborations with faculty and fellows in many divisions have resulted in more than 180 peer-reviewed and more than 120 publications.
Kevin E. Bove, MD, has 32 years experience as a pediatric pathologist at Cincinnati Children's Hospital Medical Center.
Dr. Bove has achieved national recognition as an expert in tumors; neuromuscular diseases; liver diseases of children and performance / interpretation of pediatric autopsies.
Dr. Bove has and continues to be involved in leadership positions in the Society for Pediatric Pathology and the College of American Pathologists.
MD: State University of New York, Buffalo, NY.
Residency: Rotating Intern, Cincinnati General Hospital, 1961-1962; Pathology, Cincinnati General Hospital, 1962-1966.
Certification: American Board of Pathology in Anatomic and Clinical Pathology, 1967 and 1968; Pediatric Pathology, 1990.
Manish N. Patel, DO Interventional Radiologist, Department of Radiology and Medical Imaging 513-636-6695 firstname.lastname@example.org
Interventional Radiologist, Department of Radiology and Medical Imaging
Associate Professor, UC Department of Radiology
Dr. Manish Patel, DO, has helped to expand the treatment options for high flow vascular malformations. Dr. Patel is a pediatric interventional radiologist and an associate professor of radiology. Additionally, he works as director of daily operations in the Interventional Radiology team and as the associate fellowship director of the pediatric radiology fellowship program. Dr. Patel obtained his DO degree from the University of Health Sciences – College of Osteopathic Medicine, completed his residency at University of Missouri Kansas City, and completed his fellowship at Cincinnati Children’s Hospital Medical Center. His key interests are pediatric interventional radiology, vascular access, and vascular malformations. He is currently working on research of the effects of rapamycin on VMs as well as treatment options for high flow lesions.
DO: University of Health Sciences - College of Osteopathic Medicine, Kansas City, MO, 1999.
Internship: Metropolitan Hospital, Grand Rapids, MI.
Residency: University of Missouri-Kansas City, Kansas City, MO.
Fellowship: Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
Certification: American Board of Radiology and American Osteopathic Board of Radiology, 2004.
Sheyn DD, Racadio JM, Racadio JM, Patel MN, Kukreja K, Rampton JW, Johnson ND. Use of an Amplatz Dilator to Facilitate Transrectal Abscess Drainage in Children. J Vasc Interv Radiol. 2011 Feb 18.
Sheyn DD, Racadio JM, Ying J, Patel MN, Racadio JM, Johnson ND. Efficacy of a radiation safety education initiative in reducing radiation exposure in the pediatric IR suite. Pediatr Radiol. 2008 Jun;38(6):669-74.
Racadio JM, Babic D, Homan R, Rampton JW, Patel MN, Racadio JM, Johnson ND. Live 3D guidance in the interventional radiology suite. AJR Am J Roentgenol. 2007 Dec;189(6):W357-64. Review.
John M. Racadio, MD Division Chief, Interventional Radiology, Department of Radiology and Medical Imaging 513-636-3385 email@example.com
Division Chief, Interventional Radiology, Department of Radiology and Medical Imaging
Professor, UC Department of Radiology
Vascular access; gastrointestinal interventional radiology
John Racadio, MD, has been practicing interventional radiology (IR) for 14 years and has been the division chief of interventional radiology at Cincinnati Children’s Hospital Medical Center for the past 11 years. He has expertise in performing a wide range of vascular procedures including angiography, angioplasty, embolization, vascular access, and thrombolysis in patients ranging from 500g to 150kg.
He is also the director of the interventional radiology research lab, which is part of the Department of Radiology Imaging Research Center (IRC). This state-of-the-art IR lab, which is identical to our clinical IR labs, possesses cutting edge digital flat detector technology including 3-D rotational angiography (3DRA), 3-D Roadmapping, and C-arm cone beam CT. These features provide superior image quality for digital subtraction angiography, 3-D angiography reconstruction, and “CT-like” imaging. Lab support staff includes RT(R) licensed IR technologists, and an IR lab manager. The long term goal of the IR research lab is to develop new image guided interventional procedures and imaging techniques and protocols to improve clinical outcomes. Having an IR research lab identical to our IR clinical labs facilitates translation of lab results into clinical practice.
BS: Stanford University, Palo Alto, CA, 1987.
MD: University of Cincinnati, Cincinnati, OH, 1992.
Residency: University of Cincinnati, Cincinnati, OH, 1993-1997.
Fellowship: Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 1997-1998.
Certification: Certificate of Added Qualifications, Pediatric Radiology, November 2001; Diagnostic Radiology, American Board of Radiology, 1997.
Hawkins CM, Racadio JM, McKinney DN, Racadio JM, Vu DN. Varicocele retrograde embolization with boiling contrast medium and gelatin sponges in adolescent subjects: a clinically effective therapeutic alternative. J Vasc Interv Radiol. 2012 Feb;23(2):206-10.
Patel MN, Racadio JM, Levitt MA, Bischoff A, Racadio JM, Peña A. Complex cloacal malformations: use of rotational fluoroscopy and 3-D reconstruction in diagnosis and surgical planning. Pediatr Radiol. 2012 Mar;42(3):355-63.
Sheyn DD, Racadio JM, Racadio JM, Patel MN, Kukreja K, Rampton JW, Johnson ND. Use of an Amplatz dilator to facilitate transrectal abscess drainage in children. J Vasc Interv Radiol. 2011 May;22(5):687-90.
Racadio JM, Kukreja K. Pediatric biliary interventions. Tech Vasc Interv Radiol. 2010 Dec;13(4):244-9.
Sidhu M, Strauss KJ, Connolly B, Yoshizumi TT, Racadio J, Coley BD, Utley T, Goske MJ. Radiation safety in pediatric interventional radiology. Tech Vasc Interv Radiol. 2010 Sep;13(3):158-66.
Vo NJ, Hammelman BD, Racadio JM, Strife CF, Johnson ND, Racadio JM. Anatomic distribution of renal artery stenosis in children: implications for imaging. Pediatr Radiol. 2006 Oct;36(10):1032-6.
Williams JM, Racadio JM, Johnson ND, Donnelly LF, Bissler JJ. Embolization of renal angiomyolipomata in patients with tuberous sclerosis complex. Am J Kidney Dis. 2006 Jan;47(1):95-102.
Fricke BL, Racadio JM, Duckworth T, Donnelly LF, Tamer RM, Johnson ND. Placement of peripherally inserted central catheters without fluoroscopy in children: initial catheter tip position. Radiology. 2005 Mar;234(3):887-92.
Racadio JM, Doellman DA, Johnson ND, Bean JA, Jacobs BR. Pediatric peripherally inserted central catheters: complication rates related to catheter tip location. Pediatrics. 2001 Feb;107(2):E28.
Alexander J. Towbin, MD Radiologist, Department of Radiology and Medical Imaging 513-636-5896 firstname.lastname@example.org
Radiologist, Department of Radiology and Medical Imaging
Neil D. Johnson Chair, Radiology Informatics
Co-Chief, Thoracoabdominal Imaging
Radiology informatics; cancer imaging; abdominal imaging
Hummel T, Anyane-Yeboa A, Mo J, Towbin A, Weiss B. Response of NF1-related plexiform neurofibroma to high-dose carboplatin. Pediatr Blood Cancer. 2011 Mar;56(3):488-90.
Towbin AJ, Luo GG, Yin H, Mo JQ. Focal nodular hyperplasia in children, adolescents, and young adults. Pediatr Radiol. 2011 Mar;41(3):341-9.
Towbin AJ, Hall S, Moskovitz J, Johnson ND, Donnelly LF. Creating a comprehensive customer service program to help convey critical and acute results of radiology studies. AJR Am J Roentgenol. 2011 Jan;196(1):W48-51. Hawkins CM, Towbin AJ. Rupture of the left mainstem bronchus following endotracheal intubation in a neonate. Pediatr Radiol. 2010 Nov 13.
Donnelly LF, Gessner KE, Dickerson JM, Koch BL, Towbin AJ, Lehkamp TW, Moskovitz J, Brody AS, Dumoulin CL, Jones BV. Quality initiatives: department scorecard: a tool to help drive imaging care delivery performance. Radiographics. 2010 Nov;30(7):2029-38.
Towbin AJ, Chaves I. Chronic granulomatous disease. Pediatr Radiol. 2010 May;40(5):657-68; quiz 792-3. Rayburg M, Kalinyak KA, Towbin AJ, Baker PB, Joiner CH. Fatal bone marrow embolism in a child with hemoglobin SE disease. Am J Hematol. 2010 Mar;85(3):182-4. Rayburg M, Towbin A, Yin H, Maugans T, Maurer B, Nagarajan R, Weiss B. Langerhans cell histiocytosis in a patient with stage 4 neuroblastoma receiving oral fenretinide. Pediatr Blood Cancer. 2009 Dec;53(6):1111-3. Towbin AJ, Ying J, Fleck R. Transient hepatic attenuation differences in neonates. Pediatr Radiol. 2009 Aug;39(8):798-803. Towbin AJ. The CT appearance of intraoral chewing gum. Pediatr Radiol. 2008 Dec;38(12):1350-2.
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