Lupus Center

  • Meet the Team

    The Lupus Center at Cincinnati Children's is home to specialists with a wide variety of backgrounds and areas of focus. As a team, this diversity makes us better prepared to care for your child.

  • Show All

    Rheumatologists

    Hermine I. Brunner, MD, MSc

    Professor, UC Department of Pediatrics

    Phone: 513-636-4676

    Fax: 513-636-4116

    Email: hermine.brunner@cchmc.org

    Show All

    Specialties

    Clinical Interests

    Health-related quality of life; outcome research; lupus

    Research Interests

    Economic analyses; HRQOL; measurement development; outcome research; lupus 

    Visit the Brunner Lab.

    Biography

    Hermine Brunner, MD, MSc, is a pediatric rheumatologist with a special clinical and research interest in pediatric lupus. Her research is focused on biomarker discovery and the testing of new medications for lupus. She is also involved in trial design and provides statistical support at Cincinnati Children's. As head of the Lupus Center, she is involved in the conduction of the Lupus Clinic and the organization of Lupus Support Groups. She also pioneers the development of outcome measures and improving the quality of clinical of children with lupus and other rheumatic diseases.

    Education and Training

    MD: Ludwig Maximilan University, Munich, Germany, 1991.

    Residency: University of Chicago, 1997.

    Fellowship: University of Toronto & Cincinnati, 1999.

    MSc: Clinical Epidemiology: University of Toronto, 1999.

    Certification: Pediatrics 1997; Rheumatology 2002.

    Publications

    View PubMed Publications

    Alexei A. Grom, MD

    Professor, UC Department of Pediatrics

    Phone: 513-636-3339

    Fax: 513-636-3328

    Email: alexei.grom@cchmc.org

    Show All

    Specialties

    Biography

    The research of Alexei Grom, MD, has mainly involved two translational projects focused on two autoimmune diseases – systemic juvenile rheumatoid arthritis and juvenile dermatomyositis. In both projects, recent advances of cellular immunology are applied to these diseases to promote better understanding of their pathogenesis and treatment.

    Systemic onset juvenile rheumatoid arthritis and an associated condition known as macrophage activation syndrome are severe and often devastating illnesses. The pathological mechanisms are not known but Dr. Alexei Grom has focused his research on NK and cytotoxic cell function in this disease. The rationale for this approach has been based on the strong clinical similarities between MAS and the better understood autosomal recessive disorder familial hemophagocytic lymphohistiocytosis, in which the uncontrolled proliferation of T cells and macrophages has been recently associated with decreased NK cell and cytotoxic cell functions secondary to mutations in the gene encoding perforin. Recent observations suggest as in FHLH, MAS patients also have profoundly depressed NK function. Moreover, a large subgroup of systemic JRA patients has very similar immunologic abnormalities. Combined with the evidence of the immunoregulatory role of NK cells in many immune responses, this suggests that NK dysfunction is relevant to the pathogenesis of MAS. New directions have thus been established for research in this poorly understood disease.

    Juvenile dermatomyositis is a chronic inflammatory condition involving primarily muscles and skin. The most characteristic feature of JDM is vascular damage associated with the capillary necrosis that eventually leads to capillary loss and tissue ischemia. The project is based on the hypothesis that capillary loss in this condition may be caused by angiostatic chemokines that are prominent in the inflammatory response in the affected muscles.

    Education and Training

    MD: Leningrad (St. Petersburg) Pediatric Medical Institute, Russia, 1986. 

    Residency: Leningrad (St. Petersburg) Medical Institute, Russia, 1988; Children's Hospital Medical Center, Cincinnati, Ohio, 1998. 

    Fellowship: Leningrad (St. Petersburg) Pediatric Medical Institute, Russia, 1991; Children's Hospital Medical Center, Cincinnati, Ohio, 1995. 

    Certification: Pediatrics, 1999.

    Publications

    View PubMed Publications

    A photo of Jennifer Huggins.

    Jennifer L. Huggins, MD
    Fellowship Program Director, Division of Rheumatology

    513-803-0649

    jennifer.huggins@cchmc.org

    A photo of Jennifer Huggins.

    Jennifer L. Huggins, MD

    Fellowship Program Director, Division of Rheumatology

    Associate Professor, UC Department of Pediatrics

    Phone: 513-803-0649

    Email: jennifer.huggins@cchmc.org

    Show All

    Education and Training

    MD: University of Kansas Medical School, Kansas City, Kansas 

    Publications

    View PubMed Publications
    A photo of Daniel Lovell.

    Daniel J. Lovell, MD, MPH
    Associate Director, Division of Rheumatology

    513-636-4676

    daniel.lovell@cchmc.org

    Daniel J. Lovell, MD, MPH

    Associate Director, Division of Rheumatology

    Professor, UC Department of Pediatrics

    Phone: 513-636-4676

    Fax: 513-636-5990

    Email: daniel.lovell@cchmc.org

    Show All

    Specialties

    Clinical Interests

    Diagnostic evaluation and ongoing care of children with all pediatric onset rheumatic diseases

    Research Interests

    Performance of clinical trials in children with rheumatic diseases; clinical trials methodology; mentoring of junior faculty

    Education and Training

    MD: University of Kansas, Kansas City, Kan., 1978. 

    MPH: University of Texas School of Public Health, Houston, Texas, 1982. 

    Residency: Children's Mercy Hospital, Kansas City, Kan. 

    Fellowship: Baylor College of Medicine, Houston, Texas. 

    Certification: Pediatrics, 1984; Pediatric Rheumatology, 1992.

    Publications

    View PubMed Publications

    Nephrologists

    A photo of Prasad Devarajan.

    Prasad Devarajan, MD
    Director, Division of Nephrology and Hypertension

    513-636-4531

    prasad.devarajan@cchmc.org

    Prasad Devarajan, MD

    Director, Division of Nephrology and Hypertension

    Medical Director, Stone Center

    Director, Nephrology and Hypertension Clinical Laboratory

    Louise M. Williams Endowed Chair

    Professor, UC Department of Pediatrics

    Phone: 513-636-4531

    Fax: 513-636-7407

    Email: prasad.devarajan@cchmc.org

    Show All

    Specialties

    Clinical specialties: Acute kidney injury, nephrotic syndrome, kidney stones

    Visit the Devarajan Lab.

    Education and Training

    Premedical Studies: Bombay University, India, 1979. 

    MD: Bombay University, India, 1985.

    Publications

    View PubMed Publications
    A photo of Jens W. Goebel.

    Jens W. Goebel, MD
    Clinical Director, Nephrology and Hypertension

    513-636-4531

    jens.goebel@cchmc.org

    Jens W. Goebel, MD

    Clinical Director, Nephrology and Hypertension

    Medical Director, Kidney Transplantation

    Clinical Director, Kidney Transplantation

    Professor, UC Department of Pediatrics

    Phone: 513-636-4531

    Fax: 513-636-7407

    Email: jens.goebel@cchmc.org

    Show All

    Specialties

    Clinical Interests

    Organ transplantation in children

    Research Interests

    Transplant-relevant immunology 

    Biography

    Dr. Goebel was recruited by Cincinnati Children's Hospital Medical Center in 2002 from the University of Kentucky to enhance the institution's Kidney Transplant Program. His efforts along these lines focus both on further improving the clinical care of pediatric kidney transplant recipients and their families, as well as advancing basic and translational investigations into immunological aspects especially relevant to the field of transplantation.

    Education and Training

    MD: University of Heidelberg (Germany), 1991.

    Residency and Chief Residency: Department of Pediatrics, University of South Alabama, Mobile, AL, 1991 to 1995.

    Fellowship: Section of Pediatric Nephrology, Tulane University Medical Center, New Orleans, LA, 1995 to 1998.

    Certifications: General Pediatrics, 1994, 2002; Pediatric Nephrology, 1999.

    Publications

    View PubMed Publications

    Grants

    Center-PI / Co-Investigator / Collaborator:

    NIH UO1 grant: Noninvasive Monitoring to Predict Outcome in de novo Kidney Transplant Recipients (CTOT-01, Protocol Chair: P. Heeger, MD, City), commenced in late 2005 and ongoing

    NIH UO1 grant: Health and Literacy in Child and Adult Assessment: Expanded Testing of the Pediatric PROMIS (Patient Reported Outcomes Measurement Information System) Tool (Sponsor: D. DeWalt, MD, MPH, ), ongoing.

    NIH UO1 grant: Chronic Kidney Disease in Children (CKID, PI: B. Warady, MD, Children’s Mercy Hospital, Kansas City, MO), ongoing.

    NIH RO1 grant: Calcineurin Inhibitor Minimization And Foxp3+ Tregs Post-Transplant (PIs: Wayne Hancock, MD, Children’s , and John Bucuvalas, MD, Cincinnati Children’s Hospital), ongoing.

    Midwest Pediatric Nephrology Consortium: Assessing and Implementing Transition to Adult Care in Children with CKD (PI: M. Ferris, MD, MPH, PhD, ), ongoing

    Amgen Pharmaceuticals: Pediatric Anemia Correction Study (Protocol 20050256), ongoing.

    Roche Pharmaceuticals: Development of Population Pharmacokinetic models of Mycophenolic Acid for use in Bayesian Dose Individualization in Pediatric Kidney Transplant Patients (PI: A. Vinks, Cincinnati Children’s Hospital), ongoing.

    Cincinnati Children’s Hospital Medical Center Outcomes Research Award: Validation of a Real-Time Adherence Assessment System (PI: A. Pai, PhD, Cincinnati Children’s Hospital), ongoing.

    Cincinnati Children’s Hospital Medical Center Translational Research Initiative grant: Pharmacogenetics of Mycophenolic Acid in Kidney Transplant Patients (PI: A. Vinks, Cincinnati Children’s Hospital), ongoing.

    Cincinnati Children’s Hospital Medical Center Translational Research Initiative grant: Biomarkers for Patient-tailored Therapies in Pediatric Lupus Nephritis using Mycophenolic Acid (PI: H. Brunner, Cincinnati Children’s Hospital), ongoing.

    Cincinnati Children’s Hospital Medical Center Translational Research Initiative grant: Pharmacogenetics of IMPDH in Kidney Transplant Patients (PI: A. Vinks, Cincinnati Children’s Hospital), ongoing.


    Pharmacologist

    A photo of Sander Vinks.

    Alexander A. Vinks, PharmD, PhD, FCP
    Director, Division of Clinical Pharmacology

    513-636-0159

    sander.vinks@cchmc.org

    Sander A. Vinks, PharmD, PhD, FCP

    Director, Division of Clinical Pharmacology

    Professor, UC Department of Pediatrics

    Adjunct Professor of Pharmacology

    Phone: 513-636-0159

    Fax: 513-636-0168

    Email: sander.vinks@cchmc.org

    Show All

    Biography

    Dr. Vinks received his MS in pharmacology from the University of Toronto, Canada and a pharmacy degree and PhD in pharmacology from Leiden University, The Netherlands. He was trained as a hospital pharmacist (PharmD) and clinical pharmacologist at The Hague Hospitals Central Pharmacy, The Hague, The Netherlands.

    Before joining the Division of Pharmacology Research at Cincinnati Children's Hospital Medical Center, he was director of the Clinical Pharmacology & Toxicology Laboratory at The Hague. Dr. Vinks has spent over 20 years in the field of therapeutic drug monitoring and applied pharmacokinetics, both in the research aspects of population pharmacokinetic studies, as well as in the clinical application of these approaches to clinical patient care.

    Dr. Vinks holds an academic appointment with the University of Cincinnati College of Medicine and is the principal investigator for the Pediatric Pharmacology Research Unit (PPRU). He is director of the Laboratory of Applied Pharmacokinetics and Therapeutic Drug Management (LAP/TDM) and clinical pharmacology fellowship program at Cincinnati Children's. His current research interests include pharmacokinetic-pharmacodynamic (PK-PD) modeling and the application of population and simulation methods in TDM and clinical trial design. He has authored over 50 publications in the area of TDM, pharmacokinetics and clinical pharmacology. Dr. Vinks has been actively involved with International Association of Therapeutic Drug Monitoring and Clinical Toxicology from the beginning. He is chair of the TDM cost-effectiveness committee, serves as secretary of the Executive Board of Directors, and is on the editorial board of the journal Therapeutic Drug Monitoring. Dr. Vinks is both board certified in clinical pharmacology and toxicology and is a fellow of the American College of Clinical Pharmacology.

    Education and Training

    Certification American Board of Clinical Pharmacology, 2001.

    PhD Clinical Pharmacology, Leiden University, Leiden The Netherlands, 1996.

    PharmD Hospital Pharmacy, The Hague Central Hospital Pharmacy, The Hague, The Netherlands, 1986 .

    MS Pharmacology, University of Toronto, Toronto Canada, 1983.

    MS Pharmacy, Leiden University, Leiden, The Netherlands, 1982.

    Publications

    View PubMed Publications

    Nurses

    A photo of Janalee Taylor.

    Janalee Taylor, MSN, APRN, CNS
    Associate Clinical Director

    513-636-4676

    janalee.taylor@cchmc.org

    Janalee Taylor, MSN, APRN, CNS

    Associate Clinical Director

    Nurse Pracitioner, Division of Rheumatology

    Phone: 513-636-4676

    Fax: 513-636-4116

    Email: janalee.taylor@cchmc.org

    Show All

    Specialties

    Care of children with pediatric rheumatic diseases; self-management and patient education; quality improvement and patient outcomes

    Education and Training

    MSN: Indiana University, Indianapolis, Indiana, 1986.

    BSN: Indiana University, Indianapolis, Indiana, 1978.

    Publications

    View PubMed Publications