• Research

    The Movement Disorder Clinic is committed to patient care, education and research. Research holds the key to improving outcomes. For example, it may provide an opportunity for individuals to learn more about themselves and their medical conditions. Research can also help others, and many children and adults who participate in studies feel good about the time they spend in a study. In our research program, we try to teach brain science to research participants and let them know how important their contribution has been.

    People who participate in research need not be severely affected by a medical condition. Sometimes, it is important to involve individuals with mild symptoms. Sometimes unaffected individuals may also participate.

    We do unique research and we also participate in research with other major centers. Our research on movement disorders examines such questions as:

    • Can we safely stimulate damaged areas of the brain to enhance recovery? (This involves treating adult stroke patients but we hope to bring these treatments to children.)
    • How do children develop fine motor skills independently in each hand?
    • What are the risk factors and outcomes in psychogenic movement disorders?
    • What psychiatric symptoms occur in patients with movement disorders such as Sydenham’s chorea?
    • What are the progressive symptoms of child- or adolescent-onset Huntington disease?
    • Motor skill development and brain motor-cortex function in children with ADHD compared to typically developing children, funded by the NIH. This research uses Transcranial Magnetic Stimulation.
    • Safety of a new technique in treating adults with aphasia after strokes, funded by the University of Cincinnati. This research uses Transcranial Magnetic Stimulation.
    • “Neuroplasticity” in the motor system in Tourette syndrome – how the brain’s neurons modify connections in the movement system and how this may relate to symptoms of Tourette, funded by the TSA-USA. This research uses Transcranial Magnetic Stimulation.
    • “Neuroplasticity” in the motor system in neurofibromatosis. This research uses Transcranial Magnetic Stimulation.
    • Features of psychogenic movement disorders.

    Dalal P, Leslie ND, Lindor NM, Gilbert DL, Espay AJ. Motor tics, stereotypies, and self-flagellation in Primrose Syndrome. Neurology 2010; 75:284-286.

    Ridel KR, Lipps, TD, Gilbert DL. The Prevalence of Neuropsychiatric Disorders in Children Diagnosed with Sydenham’s Chorea: a long-term follow-up of a clinic-based sample. Pediatric Neurology 2010;42:243-248.

    Hopkins SE, Somoza A, Gilbert DL. Rare Autosomal Dominant POLG1 mutation in a family with Metabolic Strokes, Posterior Column Spinal Degeneration, and Multiendocrine Disease. Journal of Child Neurology 2009. October 18 Epub ahead of print.

    Gilbert DL, Leslie EJ, Keddache M, Leslie ND. A Novel Hereditary Spastic Paraplegia with Dystonia linked to chromosome 2q24-2q31. Movement Disorders 2009; 24: 364-370.

    Wong LJ, Naviaux RK, Brunetti-Pierri N, Zhang Q, Schmitt ES, Truong C, et al. Molecular and clinical genetics of mitochondrial diseases due to POLG mutations. Hum Mutat 2008; 29:E150-E172.

    Giles LL, Delbello MP, Gilbert DL, Stanford KE, Shear PK, Strakowski SM. Cerebellar ataxia in youth at risk for Bipolar Disorder. Bipolar Disorders 2008; 10:733-737.

  • More Information

    For more information on our Movement Disorder research, contact us at tics@cchmc.org.

    Learn more about all of the research being conducted in the Division of Neurology.