Musculoskeletal Tumor Center

  • Meet the Team

    The Musculoskeletal Tumor Center is home to specialists with a wide variety of backgrounds and areas of focus. As a team, this diversity makes us better prepared to care for your child’s unique needs. Learn more about our faculty and staff.

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    Oncology

    A photo of Rajaram Nagarajan, MD.

    Rajaram Nagarajan, MD, MS
    Associate Director, Oncology Clinical Operations

    513-636-0670

    rajaram.nagarajan@cchmc.org

    Rajaram Nagarajan, MD, MS

    Associate Director, Oncology Clinical Operations

    Associate Professor, UC Department of Pediatrics

    Phone: 513-636-0670

    Fax: 513-636-3549

    Email: rajaram.nagarajan@cchmc.org

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    Specialties

    Clinical Interests

    Bone tumors; late effects of pediatric cancer therapy

    Research Interests

    Outcomes following cancer therapy and bone sarcomas

    Education and Training

    BA: Pre-Medical Sciences, Lehigh University, Bethlehem, PA, 1991.

    MD: Medical College of Pennsylvania, Philadelphia, PA, 1995.

    Internship and Residency: Pediatrics, Medical College of Virginia, Richmond, VA, 1998.

    Fellowship Training: Hematology / Oncology / BMT, University of Minnesota, Minneapolis, MN, 2002.

    MS: Clinical Research, University of Minnesota, Minneapolis, MN, 2002.

    Certifications: Pediatrics, Pediatric Hematology / Oncology.

    Publications

    View PubMed Publications
    A photo of Dr. Perentesis.

    John P. Perentesis, MD, FAAP
    Director, Division of Oncology and Cancer Programs

    513-636-8241

    john.perentesis@cchmc.org

    A photo of Dr. Perentesis.

    John P. Perentesis, MD, FAAP

    Director, Division of Oncology and Cancer Programs

    Deb Kleisinger Endowed Chair of Novel Cancer Treatments

    Executive Co-Director, Cancer and Blood Diseases Institute

    Director, Leukemia / Lymphoma Program

    Cincinnati Children's Principal Investigator, Children’s Oncology Group (COG)

    Cincinnati Children's Principal Investigator, National Cancer Institute Pediatric Phase 1 Consortium

    Professor, UC Department of Pediatrics

    Phone: 513-636-8241

    Email: john.perentesis@cchmc.org

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    Specialties

    Clinical Interests

    Acute myeloid leukemia; neuroblastoma; PNET / Ewing's sarcoma and osteosarcoma; new anticancer drug development; Phase I clinical trials

    Research Interests

    Molecular etiology and pharmacogenetics of pediatric cancers; Down syndrome-associated leukemia; new anticancer drug development

    Biography

    John P. Perentesis, MD, is a nationally recognized expert in the development of new drugs and molecular therapies for pediatric and young adult cancers and leukemia. His laboratory has developed novel anticancer drugs, and discovered genes important in the growth of normal and malignant cells. His laboratory is also developing the use of tumor and patients genetics research for personalizing therapies. In clinical research, he serves in leadership roles for the National Cancer Institute’s Investigational Drug Steering Committee and the NCI Pediatric Phase I Consortium.

    In 2010, Dr. Perentesis was elected by pediatric oncologists from across the country to the national Executive Committee for the NCI-funded Children’s Oncology Group (COG). The COG is the world's largest, cooperative children's cancer research entity. He also is in leadership efforts in the COG for new therapies for leukemia, and adolescent and young adult cancers.

    Education and Training

    MD: University of Michigan, Ann Arbor, MI, 1980.

    Residency: University of Minnesota Medical School, Minneapolis, MN, 1983.

    Fellowship: University of Minnesota Medical School, Minneapolis, MN, 1986.

    Postdoctoral: University of Minnesota Medical School, Minneapolis, MN, 1986.

    Certification: Pediatrics, 1989; Hematology/Oncology, 1990.

    Publications

    View PubMed Publications

    Grants

    The Children's Oncology Group Chair Grant. Site Principal Investigator. National Institutes of Health. Mar 2008 - Mar 2013. #U10 CA 098543.

    Children's Oncology Group Phase I. Site Principal Investigator. National Institutes of Health. Aug 2002 - Jul 2012. #U01 CA 097452.

    Children's Oncology Group New Publication Committee. National Institutes of Health. Sep 2006 - Jul 2012. #U01 CA 97542 .

    Cincinnati Children's Hyundai Scholar in Childhood Cancer Drug Development. Hyundai Hope on Wheels. Oct 2010 - Oct 2011.


    A photo of Joseph Pressey.

    Joseph G. Pressey, MD
    Director, Musculoskeletal Tumor Program

    513-803-9083

    joseph.pressey@cchmc.org

    Joseph G. Pressey, MD

    Director, Musculoskeletal Tumor Program

    Program Leader, Young Adult Oncology Center

    Associate Professor, UC Department of Pediatrics

    Phone: 513-803-9083

    Email: joseph.pressey@cchmc.org

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    Specialties

    Clinical

    Musculoskeletal tumors including rhabdomyosarcoma and other soft-tissue sarcomas; Ewing sarcoma; osteosarcoma; pediatric solid tumors; rare tumors including small cell carcinoma of the ovary.

    Research

    The development of novel therapies for pediatric sarcomas and rare tumors.

    Biography

    Dr. Pressey graduated from the University of Georgia and the Medical College of Georgia before pursuing pediatrics residency training at Cincinnati Children’s Hospital Medical Center. He trained in pediatric hematology-oncology at the Children’s Hospital of Philadelphia where he developed a keen interest in pediatric sarcomas. He spent 11 years at the University of Alabama at Birmingham School of Medicine and Children’s Hospital of Alabama where he functioned as the principal investigator (PI) for the Children’s Oncology Group (COG) phase 1 and Pilot Consortium and the Sarcoma Alliance for Research through Collaboration (SARC).

    Dr. Pressey joined the Cancer and Blood Diseases Institute at Cincinnati Children’s to direct the musculoskeletal tumor program. He is appointed clinical associate professor at the University of Cincinnati School of Medicine and functions as the Cincinnati Children’s Institutional PI for SARC. Dr. Pressey’s research is focused on the development of novel therapies for high-risk and recurrent/refractory solid tumors. Accordingly, he is developing a phase I trial for the COG phase I consortium and bench to bedside investigator initiated trials in collaboration with other investigators nationally.  

    Education and Training

    MD: Medical College of Georgia, Augusta, GA, 1995.

    Residency: Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 1998.

    Fellowship: Pediatric Hematology-Oncology, Children's Hospital of Philadelphia, Philadelphia, PA, 2001.

    Certification: Pediatric Hematology-Oncology, 2002.

    Publications

    View PubMed Publications

    Brian K. Turpin, DO

    Instructor, UC Department of Pediatrics

    Phone: 513-636-4266

    Email: brian.turpin@cchmc.org

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    Biography

    Brian K. Turpin, DO, completed his undergraduate training at the University of Missouri, graduate medical training at the Kansas City University of Medicine and Biosciences, and pediatric residency and hematology / oncology fellowship at Cincinnati Children’s Hospital Medical Center where he served as co-chief fellow. 

    Dr. Turpin’s clinical and academic interests pertain to children and young adults with solid tumors, particularly sarcomas and neuroblastomas, with a research focus on the development of new drugs and clinical trials for patients with relapsed cancer.

    Education and Training

    DO: Kansas City University of Medicine and Biosciences.

    Residency: Pediatrics, Cincinnati Children’s Hospital Medical Center.

    Fellowship: Pediatric Hematology / Oncology, Cincinnati Children’s Hospital Medical Center, Cancer and Blood Diseases Institute.

    Publications

    View Dr. Turpin's PubMed Publications

    Orthopaedic Surgery

    A photo of Joel Sorger.

    Joel I. Sorger, MD
    Co-Director, Musculoskeletal Tumor Center

    513-636-4787

    joel.sorger@cchmc.org

    Joel I. Sorger, MD

    Co-Director, Musculoskeletal Tumor Center

    Director, Pediatric Joint Replacement Surgery

    Associate Professor, UC Department of Pediatrics

    Phone: 513-636-4787

    Fax: 513-636-3928

    Email: joel.sorger@cchmc.org

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    Specialties

    Orthopaedic oncology (sarcoma surgery) and joint replacement surgery 

    Education and Training

    BS: Biology, University of Richmond, Virginia, August 1983-May 1987.

    MD: Medical College of Virginia: Richmond, Virginia, August 1987-May 1991.

    Intern: General Surgery Intern, University of Cincinnati: Cincinnati, Ohio,
    July 1991-June 1992.

    Residency: General surgery resident, University of Cincinnati College of Medicine 1992-1993; Orthopaedic surgery resident, University of Cincinnati College of Medicine 1994-1998.

    Fellowship: Orthopaedic research fellow, Noyes-Giannestras Biomechanics Lab, University of Cincinnati Department of Aerospace Engineering 1993-1994. Bone and Soft Tissue Sarcoma Management Fellowship (Orthopaedic Oncology) , Harvard University: Massachusetts General Hospital and Boston, Children’s Hospital, August 1998-July 1999

    Certification: American Board of Orthopaedic Surgeons.

    Publications

    View PubMed Publications

    Bone Marrow Transplantation

    A photo of Stella Davies.

    Stella M. Davies, MBBS, PhD, MRCP
    Director, Bone Marrow Transplantation and Immune Deficiency

    513-636-1371

    stella.davies@cchmc.org

    Stella M. Davies, MBBS, PhD, MRCP

    Director, Bone Marrow Transplantation and Immune Deficiency

    Jacob G. Schmidlapp Endowed Chair

    Professor, UC Department of Pediatrics

    Phone: 513-636-1371

    Fax: 513-803-1969

    Email: stella.davies@cchmc.org

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    Specialties

    Education and Training

    MBBS: University of Newcastle-Upon-Tyne, England, 1981.

    Clinical and Fellowship Training: The Royal Victoria Infirmary, Newcastle General Hospital and Great Ormond St. Hospital, 1981 to 1985.

    PhD: University of Newcastle-Upon-Tyne, England, 1989.

    Pediatric Fellowship: University of Minnesota, Minneapolis, MN, 1989 to 1993.

    Publications

    View PubMed Publications

    Sonata Jodele, MD

    Associate Professor, UC Department of Pediatrics

    Phone: 513-636-1565

    Fax: 513-636-3549

    Email: sonata.jodele@cchmc.org

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    Specialties

    Bone marrow transplantation

    Education and Training

    MD: Vilnius University School of Medicine, 1988-1994.

    Residency: Pediatrics, Downstate HSC at Brooklyn, Brooklyn, NY, 1998-2001.

    Fellowship: Pediatric Hematology Oncology, Children's Hospital Los Angeles and Saban Research Institute, Keck School of Medicine University of Southern California, Los Angeles, CA, 2001-2004.

    Certifications: Pediatrics, 2001; Pediatric Hematology / Oncology, 2004.

    Licenses: California, 2001-present; Ohio, 2004-present.

    Publications

    View PubMed Publications

    Researchers

    Rachid Drissi, PhD

    Assistant Professor, UC Department of Pediatrics

    Phone: 513-636-4266

    Fax: 513-636-3549

    Email: rachid.drissi@cchmc.org

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    Education and Training

    BS: University of Rouen, France, 1983.

    MS: University of Rouen, France, 1984.

    MS: University of Paris VI, France, 1988.

    PhD: University of Paris VI, France, 1994.

    Publications

    View PubMed Publications

    Joseph S. Palumbo, MD

    Associate Professor, UC Department of Pediatrics

    Phone: 513-636-4266

    Fax: 513-636-3549

    Email: joe.palumbo@cchmc.org

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    Specialties

    Interactions between the hemostatic system and innate immunity effecting tumor progression; Langerhans' cell histiocytosis

    Education and Training

    MD: Pennsylvania State University College of Medicine, Hershey, PA, 1993. 

    Residency: Childrens Hospital Medical Center, Cincinnati, OH, 1997. 

    Fellowship: Childrens Hospital Medical Center, Cincinnati, OH, 2000.

    Subspecialty: Pediatric Hematology / Oncology.

    Publications

    View PubMed Publications

    Grants

    Mechanisms Linking Metastasis to Tumor Procoagulant and Innate Immunity. Principal Investigator. National Institutes of Health. Jul 2006 - Jun 2012. #R01HL085545.

    Dao Pan, PhD

    Associate Professor, UC Department of Pediatrics

    Phone: 513-636-6315

    Fax: 513-636-1330

    Email: Dao.Pan@cchmc.org

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    Specialties

    Hematopoietic stem cells; Mesenchymal stem/progenitor cells; Gene therapy; Human genetics; Translational research; Lysosomal storage diseases

    Visit the Pan Lab.

    Education and Training

    PhD: University of Minnesota, Minneapolis, MN, 1997.

    MS: Peking Normal University, Beijing, China, 1991.

    BS: Peking Normal University, Beijing, China, 1988.

    Publications

    View PubMed Publications

    Grants

    Comprehensive Sickle Cell Center. Co-investigator. National Heart, Lung, and Blood Institute. Apr 2008 - Mar 2013. #U54 HL070871.

    Genetic Therapy for CNS Manifestations in MPS I via BBB-Targeted Protein Delivery. Principal Investigator. National Institute of Neurological Disorders and Stroke. Sep 2008 - Aug 2013. #R01 NS064330.

    Gaucher Disease: Treatment of Neurodegenerative Disease. Principal Investigator. National Institute of Neurological Disorders and Stroke. Sep 2013 - May 2018. #R01 NS086134.

    A photo of Nancy Ratner.

    Nancy Ratner, PhD
    Beatrice C. Lampkin Chair, Cancer Biology

    513-636-9469

    nancy.ratner@cchmc.org

    Nancy Ratner, PhD

    Beatrice C. Lampkin Chair, Cancer Biology

    Program Leader, Cancer and Biology and Neural Tumors Program

    Professor, UC Department of Pediatrics

    Phone: 513-636-9469

    Fax: 513-636-3549

    Email: nancy.ratner@cchmc.org

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    Specialties

    Clinical Interests

    Development of the nervous system; peripheral nerve tumor formation

    Research Interests

    Genetic mutations in tumor suppressor genes

    Visit the Ratner Lab.

    Biography

    Nancy Ratner, PhD, is interested in understanding mechanisms of peripheral nerve tumor (neurofibroma) formation in Neurofibromatosis type 1 (NF1), a common inherited disorder in which children are predisposed to cancer of the nervous system, to learning problems, bone disorders, and other cancers. She identified EGFR as a potential therapeutic target in NF1 peripheral nerve tumorigenesis, and has developed cell culture and mouse models of NF1 nerve tumorigenesis. Her laboratory has also used analysis of gene expression to identify critical genes in neurofibroma and their malignant derivatives, MPNST. 

    Dr. Ratner received her bachelor's from Brown University, her doctorate from Indiana University, and was a postdoctoral fellow at Washington University in St. Louis. She was a member of the faculty at the University of Cincinnati from 1987 to 2004. Dr. Ratner is currently a professor in the Department of Pediatrics, Cincinnati Children’s Hospital Medical Center, University of Cincinnati, and the program leader for Cancer Biology and Neural Tumors Program in the Cancer and Blood Diseases Institute where she holds the Beatrice C. Lampkin Endowed chair in cancer biology and serves as PI of the NINDS P50 “Cincinnati Center in NF Research”. 

    Dr. Ratner is an active member of the International Consortium on the Molecular Biology of NF1, NF2, and schwannomatosis and was a member of the advisory board for the National Neurofibromatosis Foundation (now Children’s Tumor Foundation) from 1989 to 2007. She chaired the Department of Defense Neurofibromatosis Research Program Integration Panel in 2008, and currently serves as a member of the James McDonnell Brain Tumor Research Advisory Board. She received the von Recklinghausen Award from the Children’s Tumor Foundation in 2010.

    Education and Training

    PhD: Indiana University, 1982.

    BA: Brown University, 1975.

    Fellowship: Washington University St. Louis, 1982-1987.

    Publications

    View PubMed Publications

    Grants

    Mitogenic Activities in Neurofibromatosis. Principle Investigator. Sept 2011-2016. NIH-R01 NS 28840-20.

    Janos Sumegi, MD, PhD

    Professor, UC Department of Pediatrics

    Phone: 513-636-5976

    Fax: 513-636-3549

    Email: janos.sumegi@cchmc.org

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    Specialties

    Lymphoproliferative disease; hemophagocytic lymphohistiocytosis; usher syndrome

    Education and Training

    MD: University Medical School of Debrecen, Hungary, 1968.

    PhD: Research Center of the Hungarian Academy of Science, Budapest, Hungary, 1974.

    Docent (DMSc): Karolinska Institute Stockhom, Sweden, 1982.

    Publications

    View PubMed Publications

    Grants

    Gene-Expression Profiling of Peripheral Blood Mononuclear Cells in Hemophagocytic Lymphohistiocytosis. Histiocytosis Association of America. Dec 2010 - Nov 2011. 

    A photo of Susanne Wells.

    Susanne Wells, PhD
    Director, Epithelial Carcinogenesis and Stem Cell Program

    513-636-5986

    susanne.wells@cchmc.org

    A photo of Susanne Wells.

    Susanne Wells, PhD

    Director, Epithelial Carcinogenesis and Stem Cell Program

    Director, Postdoctoral Office

    Associate Professor, UC Department of Pediatrics

    Phone: 513-636-5986

    Email: susanne.wells@cchmc.org

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    Specialties

    Squamous cell carcinoma; mechanisms by which the HPV oncogenes subvert the host cell machinery to promote abnormal cell growth and cancer; role of specific cellular HPV targets in viral replication and cellular transformation

    Visit the Wells Lab.

    Biography

    Susanne Wells graduated from the University of Konstanz, Germany, with a degree in Biology. She completed her PhD in Molecular Biology at the State University of Stony Brook, NY, and her Postdoctoral Fellowship at Harvard Medical School, MA. Dr. Wells moved to Cincinnati Children's Hospital Medical Center in 2002 to study human papillomavirus infection and associated carcinogenesis.

    Education and Training

    BS: Biology, University of Konstanz, Germany, 1992.

    PhD: Molecular Genetics, State University of Stony Brook, NY, 1997.

    Postdoctoral Fellowship: Molecular Virology, Harvard Medical School, Boston, MA.

    Publications

    View PubMed Publications

    Grants

    Research Innovation Fund Award
    Title:
    Identification of FA disease biomarkers using NMR-based metabonomics
    PI: Susanne Wells
    Project Period: 2013-2014
    Funding by: Cincinnati Children's Hospital Medical Center


    2R01 CA116316
    Title:
    Role and regulation of the human DEK proto-oncogene
    PI: Susanne Wells
    Project Period: 2012 – 2017
    Funding by: National Institutes of Health

    DOD Idea Award
    Title:
    Targeting the Ron-DEK signaling axis in breast cancer
    PI: Susanne Wells and Susan Waltz
    Project Period: 2012 – 2014
    Funding by: Department of Defense

    2R01 CA102357
    Title:
    Fanconi Anemia and HPV transformation
    PI: Susanne Wells
    Project Period: 2009 – 2014
    Funding by: National Institutes of Health