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The Division of Neonatology at Cincinnati Children's is home to specialists with a variety of backgrounds and areas of focus. As a team, this diversity makes us better prepared to care for your child's unique needs.
Jeffrey A. Whitsett, MD Co-Director, Perinatal Institute
Co-Director, Perinatal Institute
Chief, Section of Neonatology, Perinatal and Pulmonary Biology
Professor, UC Department of Pediatrics
Cystic fibrosis research; lung morphogenesis; control of gene expression in the respiratory epithelium; gene delivery and therapy
Visit the Whitsett Lab.
Jeffrey A. Whitsett, MD, is chief of the Section of Neonatology, Perinatal and Pulmonary Biology at Cincinnati Children's Hospital Medical Center.
Dr. Whitsett received his medical degree from Columbia University, in New York, and has been a faculty member since 1977. He is internationally known for his research in pulmonary medicine, as well as for his clinical expertise in neonatology.
Dr. Whitsett has made a series of groundbreaking contributions in pulmonary medicine. His major pioneering work has been on surfactant proteins A, B, C and D, cloning their genes, and clarifying their roles in lung development.
Throughout his career, Dr. Whitsett has had the remarkable ability to move from molecular biology, to animal models, to diagnosis and therapy of human disease. He played a critical role in making surfactant protein replacement a routine tool for treating immature lungs and respiratory distress syndrome in premature infants. His laboratory has contributed to the identification of a number of genes critical for lung formation and function. Mutations in genes regulating surfactant homeostasis were shown to cause acute and chronic lung disease in infants and adults.
Dr. Whitsett is a member of the Institute of Medicine, National Academy of Sciences and is the recipient of the Mead Johnson Award, a National Institutes of Health (NIH) Merit Award, the first Julius Comroe Lectureship in Pulmonary Research from FASEB, the William Cooper Procter Award from Cincinnati Children's, the Amberson Lecture Award of the American Thoracic Society, the prestigious Daniel Drake Medal for scientific contributions from the University of Cincinnati College of Medicine, the International Arvo Ylppö Medal from the Finnish Foundation for Pediatric Research and the Grand Hamdan International Award on Neonatal Medicine from the United Arab Emirates.
Dr. Whitsett is the author of more than 400 papers in both the basic science and clinical literature.
MD: Columbia University, New York, NY, 1973.
Residency: Pediatrics, Mt. Sinai Hospital, New York City, 1974 to 1976.
Fellowship: Neonatology, Children's Hospital Medical Center, University of Cincinnati College of Medicine, 1976 to 1977.
Sivaprasad U, Askew DJ, Ericksen MB, Gibson AM, Stier MT, Brandt EB, Bass SA, Daines MO, Chakir J, Stringer KF, Wert SE, Whitsett JA, Le Cras TD, Wills-Karp M, Silverman GA, Khurana Hershey GK. A nonredundant role for mouse Serpinb3a in the induction of mucus production in asthma. J Allergy Clin Immunol. 2011 Jan;127(1):254-61, 261.e1-6. Lin SC, Wani MA, Whitsett JA, Wells JM. Klf5 regulates lineage formation in the pre-implantation mouse embryo. Development. 2010 Dec;137(23):3953-63. Suzuki T, Sakagami T, Young LR, Carey BC, Wood RE, Luisetti M, Wert SE, Rubin BK, Kevill K, Chalk C, Whitsett JA, Stevens C, Nogee LM, Campo I, Trapnell BC. Hereditary pulmonary alveolar proteinosis: pathogenesis, presentation, diagnosis, and therapy. Am J Respir Crit Care Med. 2010 Nov 15;182(10):1292-304. Wang IC, Zhang Y, Snyder J, Sutherland MJ, Burhans MS, Shannon JM, Park HJ, Whitsett JA, Kalinichenko VV. Increased expression of FoxM1 transcription factor in respiratory epithelium inhibits lung sacculation and causes Clara cell hyperplasia. Dev Biol. 2010 Nov 15;347(2):301-14. Perl AK, Riethmacher D, Whitsett JA. Conditional Depletion of Airway Progenitor Cells Induces Peribronchiolar Fibrosis. Am J Respir Crit Care Med. 2010 Sep 24.
Tompkins DH, Besnard V, Lange AW, Keiser AR, Wert SE, Bruno MD, Whitsett JA. Sox2 Activates Cell Proliferation and Differentiation in the Respiratory Epithelium. Am J Respir Cell Mol Biol. 2010 Sep 20. Meyer SE, Hasenstein JR, Baktula A, Velu CS, Xu Y, Wan H, Whitsett JA, Gilks CB, Grimes HL. Kruppel-like factor 5 is not required for K-RasG12D lung tumorigenesis, but represses ABCG2 expression and is associated with better disease-specific survival. Am J Pathol. 2010 Sep;177(3):1503-13. Xu Y, Zhang M, Wang Y, Kadambi P, Dave V, Lu LJ, Whitsett JA. A systems approach to mapping transcriptional networks controlling surfactant homeostasis. BMC Genomics. 2010 Jul 26;11:451. Sakagami T, Beck D, Uchida K, Suzuki T, Carey BC, Nakata K, Keller G, Wood RE, Wert SE, Ikegami M, Whitsett JA, Luisetti M, Davies S, Krischer JP, Brody A, Ryckman F, Trapnell BC. Patient-derived granulocyte/macrophage colony-stimulating factor autoantibodies reproduce pulmonary alveolar proteinosis in nonhuman primates. Am J Respir Crit Care Med. 2010 Jul 1;182(1):49-61. Chen G, Wan H, Luo F, Zhang L, Xu Y, Lewkowich I, Wills-Karp M, Whitsett JA. Foxa2 programs Th2 cell-mediated innate immunity in the developing lung. J Immunol. 2010 Jun 1;184(11):6133-41.
James M. Greenberg, MD Co-Director, Perinatal Institute
Director, Division of Neonatology
Neonatal chronic lung disease; late preterm infant
Binder S, Hill K, Meinzen-Derr J, Greenberg JM, Narendran V. Increasing VLBW Deliveries at Subspecialty Perinatal Centers via Perinatal Outreach. Pediatrics. 2011 Mar;127(3):487-93.
Kulkarni RM, Herman A, Ikegami M, Greenberg JM, Akeson AL. Lymphatic ontogeny and effect of hypoplasia in developing lung. Mech Dev. 2011 Jan-Feb;128(1-2):29-40. Kulkarni RM, Greenberg JM, Akeson AL. NFATc1 regulates lymphatic endothelial development. Mech Dev. 2009 May-Jun;126(5-6):350-65.
Mallory BP, Mead TJ, Wiginton DA, Kulkarni RM, Greenberg JM, Akeson AL. Lymphangiogenesis in the developing lung promoted by VEGF-A. Microvasc Res. 2006 Jul-Sep;72(1-2):62-73.
Preciado DA, Rutter MJ, Greenberg JM, Bahado-Singh R, Lambers D, Willging JP. Intrapartum management of severe fetal airway obstruction. J Otolaryngol. 2004 Oct;33(5):283-8.
Akeson AL, Cameron JE, Le Cras TD, Whitsett JA, Greenberg JM. Vascular endothelial growth factor-A induces prenatal neovascularization and alters bronchial development in mice. Pediatr Res. 2005 Jan;57(1):82-8.
Greenberg JM, Thompson FY, Brooks SK, Shannon JM, Akeson AL. Slit and robo expression in the developing mouse lung. Dev Dyn. 2004 Jun;230(2):350-60.
Le Cras TD, Spitzmiller RE, Albertine KH, Greenberg JM, Whitsett JA, Akeson AL. VEGF causes pulmonary hemorrhage, hemosiderosis, and air space enlargement in neonatal mice. Am J Physiol Lung Cell Mol Physiol. 2004 Jul;287(1):L134-42.
Akeson AL, Greenberg JM, Cameron JE, Thompson FY, Brooks SK, Wiginton D, Whitsett JA. Temporal and spatial regulation of VEGF-A controls vascular patterning in the embryonic lung. Dev Biol. 2003 Dec 15;264(2):443-55.
Greenberg JM, Thompson FY, Brooks SK, Shannon JM, McCormick-Shannon K, Cameron JE, Mallory BP, Akeson AL. Mesenchymal expression of vascular endothelial growth factors D and A defines vascular patterning in developing lung. Dev Dyn. 2002 Jun;224(2):144-53.
Henry T. Akinbi, MD Attending Neonatologist
Associate Professor, UC Department of Pediatrics
Neonatal infections; blood transfusions; role of Lysozyme in airway host defense
McDowell SA, Ma Y, Kusano R, Akinbi HT. Simvastatin is Protective During Staphylococcus aureus Pneumonia. Curr Pharm Biotechnol. 2011 Mar 14.
Kuang Z, Hao Y, Hwang S, Zhang S, Kim E, Akinbi HT, Schurr MJ, Irvin RT, Hassett DJ, Lau GW. The Pseudomonas aeruginosa flagellum confers resistance to pulmonary surfactant protein-A by impacting the production of exoproteases through quorum-sensing. Mol Microbiol. 2011 Mar;79(5):1220-35.
Isemann B, Meinzen-Derr J, Akinbi H. Maternal and neonatal factors impacting response to methadone therapy in infants treated for neonatal abstinence syndrome. J Perinatol. 2011 Jan;31(1):25-9. Slaughter JL, Meinzen-Derr J, Rose SR, Leslie ND, Chandrasekar R, Linard SM, Akinbi HT. The effects of gestational age and birth weight on false-positive newborn-screening rates. Pediatrics. 2010 Nov;126(5):910-6.
Akinbi H, Meinzen-Derr J, Auer C, Ma Y, Pullum D, Kusano R, Reszka KJ, Zimmerly K. Alterations in the host defense properties of human milk following prolonged storage or pasteurization. J Pediatr Gastroenterol Nutr. 2010 Sep;51(3):347-52. Yang L, Johansson J, Ridsdale R, Willander H, Fitzen M, Akinbi HT, Weaver TE. Surfactant protein B propeptide contains a saposin-like protein domain with antimicrobial activity at low pH. J Immunol. 2010 Jan 15;184(2):975-83. Glasser SW, Witt TL, Senft AP, Baatz JE, Folger D, Maxfield MD, Akinbi HT, Newton DA, Prows DR, Korfhagen TR. Surfactant protein C-deficient mice are susceptible to respiratory syncytial virus infection. Am J Physiol Lung Cell Mol Physiol. 2009 Jul;297(1):L64-72. Walker VP, Akinbi HT, Meinzen-Derr J, Narendran V, Visscher M, Hoath SB. Host defense proteins on the surface of neonatal skin: implications for innate immunity. J Pediatr. 2008 Jun;152(6):777-81.
Nash JA, Ballard TN, Weaver TE, Akinbi HT. The peptidoglycan-degrading property of lysozyme is not required for bactericidal activity in vivo. J Immunol. 2006 Jul 1;177(1):519-26 Ryan MA, Akinbi HT, Serrano AG, Perez-Gil J, Wu H, McCormack FX, Weaver TE. Antimicrobial activity of native and synthetic surfactant protein B peptides. J Immunol. 2006 Jan 1;176(1):416-25.
Tanya E. Cahill, MD Director, High-Risk Clinic
Director, High-Risk Clinic
Assistant Professor, UC Department of Pediatrics
High risk infant follow up; neonatal abstinence syndrome
Michael W. Crossman, MD, PhD Attending Neonatologist
PhD: Biochemistry, St. Louis University, St. Louis Mo., 1985.
MD: St. Louis University, St. Louis, Mo., 1986.
Residency: Pediatrics, Children's Hospital Medical Center, Cincinnati, Ohio, 1986-1989; Chief resident, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, 1989-1990.
Fellowship: Neonatal- Perinatal Medical Fellowship, Washington University School of Medicine, 1990-1993.Certification: Neonatal - Perinatal Medicine, 1995, 2003.
Crossman MW. For Whom the Bells Toll… J Pediatrics. 2007;151(1):4-5.
Mishra A, Hogan SP, Brandt EB, Wagner N, Crossman MW, Foster PS, Rothenberg ME. Enterocyte expression of the eotaxin and interleukin-5 transgenes induces compartmentalized dysregulation of eosinophil trafficking. J Biol Chem. 2002 Feb 8;277(6):4406-12. Arrese M, Trauner M, Sacchiero RJ, Crossman MW, Scheider BL. Neither Intestinal Sequestration of Bile Acids nor Common Bile Duct Ligation Modulate the Expression and Function of the Rat Ileal Bile Acid Transporter. Hepatology. 1998;28:1081-1087.
Shneider BL, Setchell KDR, Crossman MW. Fetal and Neonatal Expression of the Apical Sodium-Dependent Bile Acid Transporter in the Rat Ileum and Kidney. Pediatric Research. 1997;42:189-194.
Jay H. Dritz, MD Attending Neonatologist
MD: Washington University School of Medicine, St. Louis, MO, 2001.
Residency: Pediatrics, St. Louis Children’s Hospital, St. Louis, MO, 2001-2004.
Fellowship: Neonatal-Perinatal Medicine, St. Louis Children’s Hospital, St. Louis, MO, 2004-2007.
Certification: Pediatrics, 2004; Neonatology, 2008.
Horacio S. Falciglia, MD Professor Emeritus, Neonatology and Perinatal Biology
Professor Emeritus, Neonatology and Perinatal Biology
Board Certified General Pediatrics
Meconium Aspiration Syndrome; pathophysiology
Relationship of Selenium Status to Sepsis in extremely premature infants
Horacio Falciglia, MD, serves as the Director of the Vermont Oxford Database, where he finds his work both challenging and interesting. This work allows the division to compare local (Cincinnati) neonatal outcomes, morbidities, and mortality in premature infants under 1500 grams with 600 other NICUs in the US and abroad. Dr. Falciglia also enjoys sharing years of clinical experience with new graduates and students as he teaches medical students and residents at the bedside. Dr. Falciglia's past research on Meconium Aspiration has been exciting and rewarding, and his research is leading to the understanding of the pathophysiology of this complex disease. The incidence of this disease has been drastically reduced through research and improved perinatal care.
Neera K. Goyal, MD, MSHP Attending Physician, Hospital Medicine
Attending Physician, Hospital Medicine
Quality of care during birth hospitalization for late preterm and other high risk newborns; neonatal readmission; prevention of preterm birth
Neera Goyal, MD MSHP, is a general pediatrician and a child health researcher. Her research interests are in perinatal care – in particular, how Level 1 and Level 2 birth hospitals manage higher risk term and late preterm newborns. She has studied the impact of delivery volume, teaching affiliation, and patient insurance on adherence to guidelines for postpartum length of stay, and she is currently researching the impact of discharge timing on risk of readmission for late preterm newborns. She has also conducted research on the impact of late preterm birth on early childhood respiratory morbidity and physical development. Dr. Goyal’s work has been published in peer-reviewed literature, and in 2011 she received the Pediatric Academic Societies Travel Award for Young Investigators.
Originally from Dallas, TX, Dr. Goyal received her bachelor’s degree in Atlanta, Georgia at Emory University, majoring in Philosophy. She earned her M.D. from University of Texas Southwestern Medical Center in Dallas. She completed a pediatrics residency at Children’s Hospital of Philadelphia in 2008 and worked as a neonatology hospitalist from 2008-2009. She then pursued further training in health services research as a Robert Wood Johnson Foundation Clinical Scholar at University of Pennsylvania in Philadelphia. She joined Cincinnati Children’s Hospital Medical Center in 2011 as a faculty member with a joint appointment in the Division of Neonatology and the Division of General and Community Pediatrics, Section of Hospital Medicine.
MD: Univ. of Texas Southwestern Medical Center at Dallas, 2005.
Residency: Pediatrics, Children’s Hospital of Philadelphia, 2008.
Fellowship: The Robert Wood Johnson Foundation Clinical Scholars, University of Pennsylvania, 2011
Certification: Pediatrics, 2008.
Goyal N, Fiks A, Lorch SA. The association of late preterm birth with asthma in young children: A practice-based study. Pediatrics. 2011.
Goyal N, Fager C, Lorch SA. Adherence to discharge guidelines for late preterm newborns. Pediatrics. 2011 Jul;128(1):62-71.
Beth E. Haberman, MD Senior Medical Director, Neonatal Services
Senior Medical Director, Neonatal Services
Medical Director, Newborn Intensive Care Unit (NICU)
Medical Director, Neonatal Transport Program
Associate Director, High-Risk Infant Follow-Up Program
CDH and infant follow-up; care of infants with congenital diaphragmatic hernia; follow-up care of premature and term infants with complex medical needs
Vuletin JF, Lim FY, Cnota J, Kline-Fath B, Salisbury S, Haberman B, Kingma P, Frischer J, Crombleholme T. Prenatal pulmonary hypertension index: novel prenatal predictor of severe postnatal pulmonary artery hypertension in antenatally diagnosed congenital diaphragmatic hernia. J Pediatr Surg. 2010 Apr;45(4):703-8.Greenberg JM, Donovan EF, Warner BB, Haberman BE, Narendran V, Schibler KR. Neonatal Morbidities of Prenatal and Perinatal Origin. Creasy and Resnik”s Maternal-Fetal Medicine: Principles and Practice. 2008 6th ed. Chapter 58. Elsevier Ltd., Philadelphia, PA.Castro L, Yolton K, Haberman B, Roberto N, Hansen NI, Ambalavanan N, Vohr BR, Donovan EF. Bias in reported neurodevelopmental outcomes among extremely low birth weight survivors. Pediatrics. 2004 Aug;114(2):404-10.
Crystal D. Hill, MD Attending Neonatologist
MD: Boonshoft School of Medicine, Wright State University, Dayton, Ohio.
Residency: Pediatrics,Nationwide Children’s Hospital, Columbus, Ohio.
Fellowship: Neonatal-Perinatal Medicine, Nationwide Children’s Hospital, Columbus, Ohio.
Steven B. Hoath, MD Professor Emeritus
Emeritus, UC Department of Pediatrics
Clinical aspects of Dr Hoath’s work derive from an understanding of the basics of human skin development and the multiple roles of the skin in neonatal care. New perspectives on the skin as a sensory interface are central to this understanding as is the role of the skin as an accessible environmental interface which complements ‘internal’ medicine. This view of the skin provides a unique, pivotal, and powerful opportunity to effect evidence-based organizational change in healthcare delivery to newborns. This approach highlights the criticality of the interface between Medicine and Nursing and the importance of focus on the bedside for the development of a truly “personalized” or “individualized” medicine in the future.
Epidermal barrier development (in utero and postnatal); fetal and neonatal skin adaptation (skin/environment interactions); tissue engineering of human skin (in vitro systems); innate immune function (biology of vernix and skin proteomics); development of non-invasive skin-based sensors for brain monitoring; role of the skin as a critical interface for health care delivery
Dr. Hoath graduated from Stanford University and the University of Hamburg, Germany with majors in Biology and German Studies. He received his MD from the University of California, Los Angeles and completed his Pediatric Residency and Fellowship in Neonatology at UCLA before joining Cincinnati Children’s Hospital Medical Center in 1984.
He has a longstanding interest in the development of fetal and newborn skin and the multiple roles of the skin as a critical interface for healthcare delivery in the NICU. In 1994, he was one of 7 international investigators participating in the first joint effort by NASA and the National Institutes of Health to study the effect of spaceflight and zero gravity on mammalian pregnancy and fetal development. This work grounds the idea of the skin as the ‘biological spacesuit’ for the human body.
He has authored multiple papers, chapters, and a book on neonatal skin development. He is an inventor on 5 patents awarded to Cincinnati Children’s Hospital Medical Center based on the biology of the multifunctional fetal skin ‘cream’, vernix caseosa. Recent work has focused on the logico-mathematical organization of human epidermis and the close embryological connection of the skin and the brain.
Certification: American Board of Pediatrics, June 1983; Neonatal-Perinatal Medicine, November, 1983.
Adjunct Assistant Professor: Harbor UCLA Medical Center, Los Angeles, 1983.Residency: University of California, Los Angeles, 1977-79.Internship: Harbor-UCLA Medical Center, 1976-1977.MD: University of California, Los Angeles, CA, 1976.Fellowship: Neonatology, Harbor-UCLA, Los Angeles Medical Center, 1980-1982; Pathology, UCLA School of Medicine, 1973-1974.Baccalaureate: Stanford University, Biology & German Studies, 1972.
Visscher MO, Robinson M, Fugit B, Rosenberg RJ, Hoath SB, Randall Wickett R. Amputee skin condition: occlusion, stratum corneum hydration and free amino acid levels. Arch Dermatol Res. 2010 Dec 16.
Davis JA, Visscher MO, Wickett RR, Hoath SB. Influence of tumour necrosis factor-α polymorphism-308 and atopy on irritant contact dermatitis in healthcare workers. Contact Dermatitis. 2010 Dec;63(6):320-32.
Davis JA, Visscher MO, Wickett RR, Hoath SB. Role of TNF-α polymorphism -308 in neurosensory irritation. Int J Cosmet Sci. 2010 Jul 15.
Narendran V, Visscher MO, Abril I, Hendrix SW, Hoath SB. Biomarkers of epidermal innate immunity in premature and full-term infants. Pediatr Res. 2010 Apr;67(4):382-6.
Barai ND, Boyce ST, Hoath SB, Visscher MO, Kasting GB. Improved barrier function observed in cultured skin substitutes developed under anchored conditions. Skin Res Technol. 2008 Nov;14(4):418-24.
Walker VP, Akinbi HT, Meinzen-Derr J, Narendran V, Visscher M, Hoath SB. Host defense proteins on the surface of neonatal skin: implications for innate immunity. J Pediatr. 2008 Jun;152(6):777-81.
Hoath SB, Pickens WL, Visscher MO. The biology of vernix caseosa. Int J Cosmet Sci. 2006 Oct;28(5):319-33.
Spitzmiller RE, Phillips T, Meinzen-Derr J, Hoath SB. Amplitude-integrated EEG is useful in predicting neurodevelopmental outcome in full-term infants with hypoxic-ischemic encephalopathy: a meta-analysis. J Child Neurol. 2007 Sep;22(9):1069-78.
Tansirikongkol A, Hoath SB, Pickens WL, Visscher MO, Wickett RR. Equilibrium water content in native vernix and its cellular component. J Pharm Sci. 2008 Feb;97(2):985-94.
Tansirikongkol A, Wickett RR, Visscher MO, Hoath SB. Effect of vernix caseosa on the penetration of chymotryptic enzyme: potential role in epidermal barrier development. Pediatr Res. 2007 Jul;62(1):49-53.
Alan H. Jobe, MD, PhD Director, Division of Perinatal Biology
Director, Division of Perinatal Biology
Clinical trials in neonatology; bronchopulmonary dysplasia
Lung maturation and lung injury in the fetus and newborn; use of antenatal corticosteroids; lung injury with ventilation of the preterm
Moss TJM, Nitsos I, Knox CL, Polglase GR, Kallapur SG, Ikegami M, Jobe AH, Newnham JP. Ureaplasma colonization of amniotic fluid and efficacy of antenatal corticosteroids for preterm lung maturation in sheep. AJOG. 2009;200(1):96.e1-6.
Polglase GR, Hillman NH, Ball MK, Kramer BW, Kallapur SG, Jobe AH, Pillow JJ. Lung and systemic inflammation in preterm lambs on CPAP or conventional ventilation. Pediatr Res. 2009;65(1):67-71.
Cheah F-C, Pillow JJ, Kramer BW, Polglase GR, Nitsos I, Newnham JP, Jobe AH, Kallapur SG. Airway inflammatory cell responses to intra-amniotic lipopolysaccharide in a sheep model of chorioamnionitis. Am J Physiol Lung Cell Mol Physiol. 2008;296:L384-93.
Ball MK, Jobe AH, Polglase GR, Kallapur SG, Choe-Cheah F, Hillman NH, Pillow JJ. High and low body temperature during the initiation of ventilation for near-term lambs. Resuscitation. 2008;80:133-7.
Kramer BW, Albertine KH, Moss TJM, Nitsos I, Speer CP, Newnham JP, Jobe AH. All-trans retinoic acid does not modulate intra-amniotic endotoxin mediated effects on the fetal sheep lung. The Anatomical Record. 2008;291:1271-7.
Polglase GR, Hillman NH, Pillow JJ, Cheah F-C, Nitsos I, Moss TJ, Kramer BW, Ikegami M, Kallapur SG, Jobe AH. Positive end-expiratory pressure and tidal volume during initial ventilation of preterm lambs. Pediatr Res. 2008;64:517.
Hillman N, Moss TJM, Nitsos I, Kramer BW, Bachurski C, Ikegami M, Jobe AH, Kallapur SG. Toll-like receptors and agonist responses in the developing fetal sheep lung. Pediatr Res. 2008;63:388-93.
Sweet DG, Huggett MT, Warner JA, Moss TJM, Halliday HL, Newnham JP, Kallapur SG, Jobe AH, Kramer BW. Maternal betamethasone and chorioamnionitis induce different collagenases and lung maturation in fetal sheep lungs. Neonatology. 2008;94:79-86.
Jobe AH, Moss TJM, Nitsos Il, Ikegami M, Kallapur SG, Newnham JP. Betamethasone for lung maturation: testing dose and formulation in fetal sheep. AJOG. 2007;197:523.
Moss TJM, Knox CL, Kallapur SG, Nitsos I, Theodoropoulos C, Ikegami M, Newnham JP, Jobe AH. Experimental amniotic fluid infection in sheep: effects of Ureaplasma parvum serovars 3 and 6 on preterm or term fetal sheep. Am J Ob Gyn. 2008;198:122e18.
Beth Ann Johnson, MD, MA Attending Neonatologist
Cardiac intensive care; neonatology; premature infants with congenital heart disease; mechanical assist devices; fetal diagnosis; ethics
Suhas G. Kallapur, MD Director, Neonatology Continuing Medical Education
Director, Neonatology Continuing Medical Education
Chorioamnionitis; bronchopulmonary dysplasia; respiratory distress syndrome; fetal immunity
Visit the Kallapur Lab.
Kemp MW, Kallapur SG, Jobe AH, Newnham JP. Obesity and the developmental origins of health and disease. J Paediatr Child Health. 2011 Jan 18.
Morrow AL, Meinzen-Derr J, Huang P, Schibler KR, Cahill T, Keddache M, Kallapur SG, Newburg DS, Tabangin M, Warner BB, Jiang X. Fucosyltransferase 2 Non-Secretor and Low Secretor Status Predicts Severe Outcomes in Premature Infants. J Pediatr. 2011 May;158(5):745-51.
Hillman NH, Kallapur SG, Pillow JJ, Nitsos I, Polglase GR, Ikegami M, Jobe AH. Inhibitors of inflammation and endogenous surfactant pool size as modulators of lung injury with initiation of ventilation in preterm sheep. Respir Res. 2010 Oct 29;11:151.
Shah TA, Hillman NH, Nitsos I, Polglase GR, Pillow JJ, Newnham JP, Jobe AH, Kallapur SG. Pulmonary and systemic expression of monocyte chemotactic proteins in preterm sheep fetuses exposed to lipopolysaccharide-induced chorioamnionitis. Pediatr Res. 2010 Sep;68(3):210-5.
Shah TA, Hillman NH, Nitsos I, Polglase GR, Pillow JJ, Newnham JP, Jobe AH, Kallapur SG. Pulmonary and Systemic Expression of Monocyte Chemotactic Proteins in Preterm Sheep Fetuses Exposed to LPS Induced Chorioamnionitis. Pediatr Res. 2010 May 28.
Jobe AH, Kallapur SG. Long term consequences of oxygen therapy in the neonatal period. Semin Fetal Neonatal Med. 2010 Aug;15(4):230-5.
Hillman NH, Pillow JJ, Ball MK, Polglase GR, Kallapur SG, Jobe AH. Antenatal and postnatal corticosteroid and resuscitation induced lung injury in preterm sheep. Respir Res. 2009 Dec 15;10:124.
Hillman NH, Kallapur SG, Pillow JJ, Moss TJ, Polglase GR, Nitsos I, Jobe AH. Airway injury from initiating ventilation in preterm sheep. Pediatr Res. 2010 Jan;67(1):60-5.
Jobe AH, Nitsos I, Pillow JJ, Polglase GR, Kallapur SG, Newnham JP. Betamethasone dose and formulation for induced lung maturation in fetal sheep. Am J Obstet Gynecol. 2009 Dec;201(6):611.e1-7.
Kallapur SG, Moss TJ, Auten RL Jr, Nitsos I, Pillow JJ, Kramer BW, Maeda DY, Newnham JP, Ikegami M, Jobe AH. IL-8 signaling does not mediate intra-amniotic LPS-induced inflammation and maturation in preterm fetal lamb lung. Am J Physiol Lung Cell Mol Physiol. 2009 Sep;297(3):L512-9.
Beena D. Kamath-Rayne, MD, MPH Attending Neonatologist
Perinatal epidemiology and public health; global health
Dr. Kamath-Rayne is doing collaborative research with maternal-fetal medicine on preterm birth, fetal lung maturity, and biomarker discovery in amniotic fluid. She has received a BIRCWH K12 award to fund this research. She has published on neonatal outcomes after elective Cesarean section, and after documented fetal lung maturity. Her work was required reading for the Maintenance for Certification for the American Board of Obstetrics and Gynecology in 2010.
Dr. Kamath-Rayne was a reviewer for the Helping Babies Breathe (HBB) global neonatal resuscitation curriculum, and is currently a Master Trainer. She is collaborating on several studies of HBB around the world. With Dr. Alan Jobe, she is also a neonatal consultant for MANDATE (Maternal and Neonatal Directed Assessment of Technology), a project funded by the Bill and Melinda Gates Foundation to RTI International to inform the development of technologies to decrease maternal and neonatal mortality worldwide.
Kamath-Rayne BD, DeFranco EA, Marcotte MP. Antenatal steroids for treatment of fetal lung immaturity after 34 weeks of gestation: an evaluation of neonatal outcomes. Obstet Gynecol. 2012; 119(5): 909-916.
Kamath-Rayne BD, MacGuire ER, McClure EM, Goldenberg RL, Jobe AH. Clinical algorithms for identification of sick newborns in community-based settings. Acta Paediatr. 2012; 101: 344-351.
Kamath BD, Donovan EF, Christopher R, Brodbeck J, Slone C, Marcotte MP. Using improvement science to increase accuracy and reliability of gestational age documentation. Am J of Perinatol. 2012; 29(3): 217-223.
Kamath BD, Marcotte, MP, DeFranco, EA. Neonatal morbidity after documented fetal lung maturity in late preterm and early term infants. Am J Obstet Gynecol. 2011; 204: 518.e1-e8.
Goldenberg RL, McClure EM, MacGuire ER, Kamath BD, Jobe AH. Lessons for low-income regions following the reduction in hypertension-related maternal mortality in high-income countries. Int J Gynecol Obstet. 2011; 113(2):91-5.
Kamath BD, MacGuire ER, McClure EM, Goldenberg RL, Jobe AH. Neonatal mortality from respiratory distress syndrome: a historical review with lessons for low-resource countries. Pediatrics. 2011; 127(6):1139-46.
Kamath BD, Fashaw L, Kinsella JP. Adrenal insufficiency in newborns with congenital diaphragmatic hernia. J Pediatr. 2010; 156(3):495-497.
Kamath BD, Todd JK, Glazner JE, Lezotte D, Lynch AM. Neonatal outcomes after elective Cesarean section. Obstetr Gynecol. 2009; 113(6): 1231-1238. *Required reading for Maintenance of Certification for American Board of Obstetrics and Gynecology, 2010
Kamath BD, Box TL, Simpson M, Hernández J. Infants born at the threshold of viability in relation to neonatal mortality: Colorado, 1991 to 2003. J Perinatol. 2008; 28(5): 354-360.
Jobe AH, Kamath-Rayne BD. Fetal lung development and surfactant. In: Creasy and Resnik’s Maternal-Fetal Medicine: Principles and Practice. Greene MF, Creasy RK, Resnik R, Iams JD, Lockwood CJ, Moore T (Eds.). 2012.
Heather C. Kaplan, MD, MSCE Attending Neonatologist
Heather Kaplan conducts research focusing on understanding variations in evidence-based care practices across hospitals and examining strategies for increasing the implementation of evidence into practice in perinatal care. She uses a systems lens to understand and ultimately change behavior at the individual, group, organizational, and environmental levels of the health care system.
Kaplan HC, Lannon C, Walsh MC, Donovan EF; Ohio Perinatal Quality Collaborative. Ohio statewide quality-improvement collaborative to reduce late-onset sepsis in preterm infants. Pediatrics. 2011 Mar;127(3):427-35.
Kaplan HC, Lorch SA, Pinto-Martin J, Putt M, Silber JH. Assessment of surfactant use in preterm infants as a marker of neonatal intensive care unit quality. BMC Health Serv Res. 2011 Jan 31;11:22.
Kaplan HC, Brady PW, Dritz MC, Hooper DK, Linam WM, Froehle CM, Margolis P. The influence of context on quality improvement success in health care: a systematic review of the literature. Milbank Q. 2010 Dec;88(4):500-59.
Kaplan, HC, Tabangin ME, McClendon D, Meinzen-Derr J, Margolis PA, Donovan EF. Understanding Variation in Vitamin A Supplementation Among NICUs. Pediatrics. 2010 Aug;126(2):e367-73.
Alan P. Kenny, MD, PhD Research Instructor, Department of Pediatrics, Affiliated
Research Instructor, Department of Pediatrics, Affiliated
Neonatal Care; neonatal lung disease; neonatal malformations and anomalies
Lung progenitor development; stem cell differentiation; fetal malformations
Kenny AP, Crimmins NA, Mackay DJ, Hopkin RJ, Bove KE, Leonis MA. Concurrent course of transient neonatal diabetes with cholestasis and paucity of interlobular bile ducts: a case report. Pediatr Dev Pathol. 2009 Sep-Oct;12(5):417-20.Li Y, Rankin SA, Sinner D, Kenny AP, Krieg PA, Zorn AM. Sfrp5 coordinates foregut specification and morphogenesis by antagonizing both canonical and noncanonical Wnt11 signaling. Genes Dev. 2008 Nov 1;22(21):3050-63.
Kenny A. Vitamin A for prevention of bronchopulmonary dysplasia. Preemie Press. Local news brief for Good Samaritan Hospital. 2007.
Angerer LM, Kenny AP, Newman LA, Angerer RC. Mutual antagonism of SoxB1 and canonical Wnt signaling in sea urchin embryos. Signal Transduction Wiley Interscience, New York. 2007 7(2), 174-178.
Paul S. Kingma, MD, PhD Neonatal Director, Cincinnati Fetal Center
Neonatal Director, Cincinnati Fetal Center
Neonatology; congenital diaphragmatic hernia; neonatal infection
Innate immune systems; surfactant protein D; neutrophil function in Cystic Fibrosis
Thomas R. Korfhagen, MD, PhD Attending Pediatritian, Division of Neonatologist
Attending Pediatritian, Division of Neonatologist
Care of High Risk infants; pediatric patients with complex, long term medical problems
Roles and mechanisms whereby surfactant proteins A, B, D, Relm peptides and EGF-R signaling control lung infections, inflammation and responses to lung injury. Translational studies assessing processes to reduce the extent of lung injury and remodeling in neonates and adults.
Hassett DJ, Korfhagen TR, Irvin RT, Schurr MJ, Sauer K, Lau GW, Sutton MD, Yu H, Hoiby N. Pseudomonas aeruginosa biofilm infections in cystic fibrosis: insights into pathogenic processes and treatment strategies. Expert Opin Ther Targets. 2010 Feb;14(2):117-30. Review.
Le Cras TD, Korfhagen TR, Davidson C, Schmidt S, Fenchel M, Ikegami M, Whitsett JA, Hardie WD. Inhibition of PI3K by PX-866 prevents transforming growth factor-alpha-induced pulmonary fibrosis. Am J Pathol. 2010 Feb;176(2):679-86.
Chen G, Korfhagen TR, Xu Y, Kitzmiller J, Wert SE, Maeda Y, Gregorieff A, Clevers H, Whitsett JA. SPDEF is required for mouse pulmonary goblet cell differentiation and regulates a network of genes associated with mucus production. J Clin Invest. 2009 Oct;119(10):2914-24.
Deshmukh HS, McLachlan A, Atkinson JJ, Hardie WD, Korfhagen TR, Dietsch M, Liu Y, Di PY, Wesselkamper SC, Borchers MT, Leikauf GD. Matrix metalloproteinase-14 mediates a phenotypic shift in the airways to increase mucin production. Am J Respir Crit Care Med. 2009 Nov 1;180(9):834-45.
Glasser SW, Witt TL, Senft AP, Baatz JE, Folger D, Maxfield MD, Akinbi HT, Newton DA, Prows DR, Korfhagen TR. Surfactant protein C-deficient mice are susceptible to respiratory syncytial virus infection. Am J Physiol Lung Cell Mol Physiol. 2009 Jul;297(1):L64-72.
Korfhagen TR, Le Cras TD, Davidson CR, Schmidt SM, Ikegami M, Whitsett JA, Hardie WD. Rapamycin prevents transforming growth factor-alpha-induced pulmonary fibrosis. Am J Respir Cell Mol Biol. 2009 Nov;41(5):562-72.
Kramer EL, Mushaben EM, Pastura PA, Acciani TH, Deutsch GH, Khurana Hershey GK, Korfhagen TR, Hardie WD, Whitsett JA, Le Cras TD. Early growth response-1 suppresses epidermal growth factor receptor-mediated airway hyperresponsiveness and lung remodeling in mice. Am J Respir Cell Mol Biol. 2009 Oct;41(4):415-25.
Glasser SW, Senft AP, Whitsett JA, Maxfield MD, Ross GF, Richardson TR, Prows DR, Xu Y, Korfhagen TR. Macrophage dysfunction and susceptibility to pulmonary Pseudomonas aeruginosa infection in surfactant protein C-deficient mice. J Immunol. 2008 Jul 1;181(1):621-8.
Hardie WD, Davidson C, Ikegami M, Leikauf GD, Le Cras TD, Prestridge A, Whitsett JA, Korfhagen TR. EGF receptor tyrosine kinase inhibitors diminish transforming growth factor-alpha-induced pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol. 2008 Jun;294(6):L1217-25.
Deshmukh HS, Shaver C, Case LM, Dietsch M, Wesselkamper SC, Hardie WD, Korfhagen TR, Corradi M, Nadel JA, Borchers MT, Leikauf GD. Acrolein-activated matrix metalloproteinase 9 contributes to persistent mucin production. Am J Respir Cell Mol Biol. 2008 Apr;38(4):446-54.
Yutaka Maeda, DVM, PhD Research Assistant Professor
Research Assistant Professor
Lung cancer; asthma
DVM: Hokkaido University, Sapporo, Japan, 1997.
PhD: University of California, Riverside, CA, 2002.
Maeda Y, Tsuchiya T, Hao H, Tompkins DH, Xu Y, Mucenski ML, Du L, Keiser AR, Fukazawa T, Naomoto Y, Nagayasu T, Whitsett JA. Kras(G12D) and Nkx2-1 haploinsufficiency induce mucinous adenocarcinoma of the lung. J Clin Invest.2012 Dec 3;122(12):4388-400.
Whitsett JA, Haitchi HM, Maeda Y. Intersections between pulmonary development and disease. Am J Respir Crit Care Med. 2011 Aug 15;184(4):401-6.
Maeda Y, Chen G, Xu Y, Haitchi HM, Du L, Keiser AR, Howarth PH, Davies DE, Holgate ST, Whitsett JA. Airway epithelial transcription factor NK2 homeobox 1 inhibits mucous cell metaplasia and Th2 inflammation. Am J Respir Crit Care Med. 2011 Aug 15;184(4):421-9.
Fukazawa T, Maeda Y, Matsuoka J, Ono T, Mominoki K, Yamatsuji T, Shigemitsu K, Morita I, Murakami I, Tanaka H, Durbin ML, Naomoto Y. Targeting KRAS mutation-bearing lung cancer in vivo by pulmonary surfactant-adenovirus-mediated gene transfer. Anticancer Res. 2010 Dec;30(12):4925-35.Han S, Fukazawa T, Yamatsuji T, Matsuoka J, Miyachi H, Maeda Y, Durbin M, Naomoto Y. Anti-tumor effect in human lung cancer by a combination treatment of novel histone deacetylase inhibitors: SL142 or SL325 and retinoic acids. PLoS One. 2010 Nov 4;5(11):e13834.Fukazawa T, Maeda Y, Matsuoka J, Yamatsuji T, Shigemitsu K, Morita I, Faiola F, Durbin ML, Soucek L, Naomoto Y. Inhibition of Myc effectively targets KRAS mutation-positive lung cancer expressing high levels of Myc. Anticancer Res. 2010 Oct;30(10):4193-200.
Fukazawa T, Matsuoka J, Yamatsuji T, Maeda Y, Durbin ML, Naomoto Y. Adenovirus-mediated cancer gene therapy and virotherapy (Review). Int J Mol Med. 2010 Jan;25(1):3-10.
Chen G, Korfhagen TR, Xu Y, Kitzmiller J, Wert SE, Maeda Y, Gregorieff A, Clevers H, Whitsett JA. SPDEF is required for mouse pulmonary goblet cell differentiation and regulates a network of genes associated with mucus production. J Clin Invest. 2009 Oct;119(10):2914-24.
Fukazawa T, Maeda Y, Matsuoka J, Tanaka N, Tanaka H, Durbin ML, Naomoto Y.Drug-regulatable cancer cell death induced by BID under control of the tissue-specific, lung cancer-targeted TTS promoter system. Int J Cancer. 2009 Oct 15;125(8):1975-84.
Fukazawa T, Matsuoka J, Naomoto Y, Maeda Y, Durbin ML, Tanaka N. Malignant pleural mesothelioma-targeted CREBBP/EP300 inhibitory protein 1 promoter system for gene therapy and virotherapy. Cancer Res. 2008 Sep 1;68(17):7120-9.
Kristin R. Melton, MD Associate Program Director, Neonatal-Perinatal Medicine Fellowship
Associate Program Director, Neonatal-Perinatal Medicine Fellowship
Craniofacial malformations; somitogenesis
Craniofacial defects are an important cause of morbidity for children worldwide, with craniofacial defects making up one third of all congenital anomalies and occurring in association with over 100 different genetic syndromes. Cranial neural crest cells are multipotent, migratory cells that form most of the bone, cartilage, connective tissue and peripheral nervous system of the head and face. Craniofacial defects are largely attributed to abnormalities in the formation, migration or differentiation of the neural crest. The cranial neural crest is responsive to the tissues that surround it, however, so craniofacial defects may result from a primary defect in neural crest cells, or from a defect in the tissues that signal to neural crest.
Kristin Melton, MD, has an interest in studying the tissues that signal to the neural crest, such as the endothelium and cranial mesoderm, and the signaling pathways utilized by these tissues. Using embryo culture techniques, cell culture and transgenic mouse models, Dr. Melton is investigating the interaction between the endothelium and the neural crest. Microarray has also been used to identify a number of mesoderm-specific genes that may play key roles in craniofacial development.
Dr. Melton is a practicing neonatologist and attends at the RCNIC in Cincinnati Children’s Hospital. Her clinical interests include newborns with complex congenital anomalies and genetic defects, as well as a focus on family-centered care.
Gibb S, Zagorska A, Melton K, Tenin G, Vacca I, Trainor P, Maroto M, Dale JK. Interfering with Wnt signalling alters the periodicity of the segmentation clock. Dev Biol. 2009 Jun 1;330(1):21-31.
Nesslein LL, Melton KR, Ikegami M, Na CL, Wert SE, Rice WR, Whitsett JA, Weaver TE. Partial SP-B deficiency perturbs lung function and causes air space abnormalities. Am J Physiol Lung Cell Mol Physiol. 2005 Jun;288(6):L1154-61.
Melton KR, Nesslein LL, Ikegami M, Tichelaar JW, Clark JC, Whitsett JA, Weaver TE. SP-B deficiency causes respiratory failure in adult mice. Am J Physiol Lung Cell Mol Physiol. 2003 Sep;285(3):L543-9.
Melton K, Akinbi HT. Neonatal jaundice. Strategies to reduce bilirubin-induced complications. Postgrad Med. 1999 Nov;106(6):167-8, 171-4, 177-8.
Nagendra K. Monangi, MD Attending Neonatologist
Maternal / infant nutrition; vitamin D
MBBS: Andhra Medical College, Visakhapatnam, India, 2001.
Post Graduate Diploma: Pediatrics, Osmania Medical College, Hyderabad, India, 2005.
Residency: Pediatrics, University of South Alabama, Mobile, AL, 2009.
Fellwoship: Neonatal-Perinatal Medicine, Cincinnati Children’s Hospital Medical Center / University of Cincinnati, Cincinnati, OH, 2012.
Certification: Pediatrics, 2009; Neonatology, Board Eligible.
Laurel B. Moyer, MD Medical Director, TriHealth Nurseries
Medical Director, TriHealth Nurseries
Chair, Neonatal Pediatrics
Quality improvement; global health
Vivek Narendran, MD, MRCP, MBA Medical Director, University of Cincinnati Medical Center NICU
Medical Director, University of Cincinnati Medical Center NICU
Medical Director, Cincinnati Perinatal Outreach Project
Director, Neonatal Intensive Care Unit and Newborn Services, Christ Hospital
Non-Invasive Ventilation of the Preterm Infant, Business Case for Quality Improvements
Interested in innate immunity of the skin with a particular focus on epidermal biomarkers and antimicrobial peptides on the skin surface
Binder S, Hill K, Meinzen-Derr J, Greenberg JM, Narendran V. Increasing VLBW Deliveries at Subspecialty Perinatal Centers via Perinatal Outreach. Pediatrics. 2011 Feb 14.
Sampath V, Narendran V, Donovan EF, Stanek J, Schleiss MR. Nonimmune hydrops fetalis and fulminant fatal disease due to congenital cytomegalovirus infection in a premature infant. J Perinatol. 2005 Sep;25(9):608-11.
Visscher MO, Narendran V, Pickens WL, LaRuffa AA, Meinzen-Derr J, Allen K, Hoath SB. Vernix caseosa in neonatal adaptation. J Perinatol. 2005 Jul;25(7):440-6. Review.
Akinbi HT, Narendran V, Pass AK, Markart P, Hoath SB. Host defense proteins in vernix caseosa and amniotic fluid. Am J Obstet Gynecol. 2004 Dec;191(6):2090-6.
Narendran V, Donovan EF, Hoath SB, Akinbi HT, Steichen JJ, Jobe AH. Early bubble CPAP and outcomes in ELBW preterm infants. J Perinatol. 2003 Apr-May;23(3):195-9.
Hoath SB, Narendran V. Adhesives and emollients in the preterm infant. Semin Neonatol. 2000 Nov;5(4):289-96. Review.
Narendran V, Wickett RR, Pickens WL, Hoath SB. Interaction between pulmonary surfactant and vernix: a potential mechanism for induction of amniotic fluid turbidity. Pediatr Res. 2000 Jul;48(1):120-4.
Amy T. Nathan, MD Medical Director, Neonatology
Medical Director, Neonatology
necrotizing enterocolitis; quality improvement; neonatal immune responses; family-centered care
Immune modulation of lung injury and inflammation
Innate immune responses at the epithelial boundaries in preterm infants (lung, intestine) can be protective, but inflammatory responses may also cause significant damage. Necrotizing enterocolitis is a devastating, multi-factorial disease marked by intense inflammation, which may be related to changes in the intestinal microbiome combined with compromised perfusion. Dr. Nathan focuses on antecedent factors leading to necrotizing enterocolitis, and is interested in applying quality improvement methods to reduce the incidence of this major morbidity in preterm infants.
Wills-Karp M, Nathan A, Page K, Karp CL. New insights into innate immune mechanisms underlying allergenicity. Mucosal Immunol. 2010 Mar;3(2):104-10.
Nathan AT, Peterson EA, Chakir J, Wills-Karp M. Innate immune responses of airway epithelium to house dust mite are mediated through beta-glucan-dependent pathways. J Allergy Clin Immunol. 2009 Mar;123(3):612-8.
Chavez-Valdez R, Ahlawat R, Wills-Karp M, Nathan AT, Ezell T, and Gauda EB. Correlation between serum caffeine levels and changes in cytokine profile in a cohort of preterm infants. J Peds. Aug 5 2010.
Wexelblatt, SL, Greenberg, JM, and Nathan AT. Regional care model enables rapid response to adverse drug events. J Perintatol. 2010 30: 300-2.
Chavez-Valdez R, Wills-Karp M, Ahlawat R, Cristofalo EA, Nathan AT, and Gauda EB. Caffeine modulates TNF- production by cord blood monocytes; the role of adenosine receptors. Ped Research. 2009 65(2):203-8. Wendel KR, Nathan AT. Inhaled nitric oxide. Newborn and Infant Nursing Reviews. 2006 6(2):100-105.
Mihaela Pavlicev, PhD
PhD: University of Vienna, Austria, 2003.
Postdoc: Washington University St. Louis (with Jim Cheverud), University of Oslo (with Thomas Hansen).
Pavličev M, Wagner GP. A model of developmental evolution: selection, pleiotropy, compensation. TrEE. 2012;27: 316-322.
Pavličev M, Hansen TF. Genotype-phenotype maps maximizing evolvability: modularity revisited. Evolutionary Biology. 2011;38: 371-389.
Pavličev M, Norgard EA, Fawcett GL, Cheverud JM. Evolution of pleiotropy: Epistatic interaction pattern supports a mechanistic model underlying variation in genotype-phenotype map. J. Experimental Zoology B. 2011;316B: 371-385.
Pavličev M, Wagner GP, Cheverud JM. Evolution of adaptive phenotypic variation patterns by direct selection on evolvability. Proc. Roy. Soc. 2011;278: 1903-1912.
Pavličev M, Le Rouzic AP, Wagner GP, Cheverud JM, Hansen TF. Directionality of epistasis in a murine intercross population. Genetics. 2010;185:1489-1505.
Pavličev M, Cheverud JM, Wagner GP. Measuring morphological integration using eigenvalue variance. Evolutionary Biology. 2009;36:157-170.
Wagner GP, Kenney-Hunt JP, Pavličev M, Peck JR, Waxman D, and Cheverud JM. Pleiotropic scaling of gene effects and the "Cost of complexity". Nature. 2008;452: 470-472.
Pavličev M, Kenney-Hunt JP, Norgard AE, Roseman CC, Wolf J, and Cheverud JM. Genetic variation in pleiotropy: Differential epistasis as a source of variation in the allometric relationships between bone lengths and body weight. Evolution. 2008;62 (1): 199-213.
Wagner GP, Pavličev M, Cheverud JM. The road to modularity. Nature Reviews Genetics. 2007;8: 921- 931.
John H. Reuter, MD, PhD Attending Neonatologist
Chair, Department of Pediatrics at Bethesda North Hospital Nurseries
MD: University of Cincinnati College of Medicine, Cincinnati, Ohio, 1976.PhD: Physiology, University of Cincinnati College of Medicine, 1973.
Residency: Pediatrics, University of Cincinnati and Children's Hospital Medical Center, Cincinnati, Ohio, 1978.
Fellowship: Moffitt Hospital, Cardiovascular Research Institute, University of California at San Francisco, San Francisco, Calif., 1980.
Certifications: Pediatrics, 1982 Neonatal; Perinatal Medicine, 1983.
Ward R. Rice, MD, PhD Medical Director, Newborn Services, St. Elizabeth Medical Center
Medical Director, Newborn Services, St. Elizabeth Medical Center
Director, Neonatology Fellowship Training Program
Hypotension in ELBW infants; EMR
Processing of Surfactant Protein C
Ward R. Rice, MD, PhD, is the Director of the Neonatology Fellowship Training Program and Director of Newborn Services, St. Elizabeth Medical Center.
Dr. Rice received MD and PhD degrees from the University of Chicago and has been on the faculty since 1983. He has been the Director of the Neonatology Fellowship Training Program since 1990. During this time, he has supervised the clinical training of more than 100 fellows who currently hold academic appointments across the United States and around the world.
His past NIH supported research accomplishments included identification of novel G-protein coupled receptors on alveolar type II cells and studies of the interaction of the opportunistic pathogen P carinii with alveolar type II cells. He currently works in collaboration with Dr. Timothy Weaver to study biosynthesis of Surfactant Protein C.
PhD: 1972-76 University of Chicago, Chicago, Illinois.
PhD: Biochemistry, Thesis Advisor: T.L. Steck, MD, Thesis: "Pyruvate Flux Across The Isolated Human Erythrocyte Membrane"
MD: 1972-78 University of Chicago, Chicago, Illinois.
Internship: 1978-79 Duke University Medical Center, Durham, North Carolina.
Residency: 1979-81 Duke University Medical Center, Durham, North Carolina.
Fellowship Neonatology: 1981-83 University of Cincinnati College of Medicine, Children's Hospital Medical Center.
Certification: Pediatrics, 1983; Sub-board Neonatal-Perinatal Medicine, 1983.
Conkright JJ, Apsley KS, Martin EP, Ridsdale R, Rice WR, Na CL, Yang B, Weaver TE. Nedd4-2-mediated ubiquitination facilitates processing of surfactant protein-C. Am J Respir Cell Mol Biol. 2010 Feb;42(2):181-9.
Rice WR, Conkright JJ, Na CL, Ikegami M, Shannon JM, Weaver TE. Maintenance of the mouse type II cell phenotype in vitro. Am J Physiol Lung Cell Mol Physiol. 2002 Aug;283(2):L256-64.
Huffman Reed JA, Rice WR, Zsengellér ZK, Wert SE, Dranoff G, Whitsett JA. GM-CSF enhances lung growth and causes alveolar type II epithelial cell hyperplasia in transgenic mice. Am J Physiol. 1997 Oct;273(4 Pt 1):L715-25.
Rice W, Shannon JM, Burton F, Fiedeldey D. Expression of a brain-type cannabinoid receptor (CB1) in alveolar Type II cells in the lung: regulation by hydrocortisone. Eur J Pharmacol. 1997 May 30;327(2-3):227-32.
Linke MJ, Burton FM, Fiedeldey DT, Rice WR. Surfactant phospholipid secretion from rat alveolar type II cells: possible role of PKC isozymes. Am J Physiol. 1997 Feb;272(2 Pt 1):L171-7.
Chroneos ZC, Abdolrasulnia R, Whitsett JA, Rice WR, Shepherd VL. Purification of a cell-surface receptor for surfactant protein A. J Biol Chem. 1996 Jul 5;271(27):16375-83.
Haas M, Rice WR. Respiratory distress syndrome for the practicing pediatrician. Pediatr Ann. 1995 Nov;24(11):572-6, 579-80. Review.
Rice WR, Burton FM, Fiedeldey DT. Cloning and expression of the alveolar type II cell P2u-purinergic receptor. Am J Respir Cell Mol Biol. 1995 Jan;12(1):27-32.
Rice WR, Singleton FM, Linke MJ, Walzer PD. Regulation of surfactant phosphatidylcholine secretion from alveolar type II cells during Pneumocystis carinii pneumonia in the rat. JClin Invest. 1993 Dec;92(6):2778-82.
Jerod M. Rone, MD Medical Director, Kettering Medical Center NICU
Medical Director, Kettering Medical Center NICU
MD: Wright State University School of Medicine, Dayton, OH, 1991.
Residency: Pediatrics, Wright State University School of Medicine, Dayton Children’s Medical Center, Dayton, OH, 1995.
Fellowship: Neonatal-Perinatal Medicine, University of Cincinnati, CCHMC, Cincinnati, OH, 1998.
Certification: Neonatal-Perinatal Medicine, 1999.
Kurt R. Schibler, MD Director, Neonatology Clinical Research Program
Director, Neonatology Clinical Research Program
Clinical trials; neonatal immune development
Immune mechanisms underlying morbidity and mortality associated with preterm birth; necrotizing enterocolitis; complications of prematurity
MD: University of Cincinnati, Cincinnati, Ohio, 1984.
Residency: Pediatrics, Indiana University, Indianapolis, Indiana, 1990.
Fellowship: Neonatology, University of Utah, Salt Lake City, Utah, 1993.
Certification: Pediatrics 1990; Neonatal-Perinatal Medicine 1993, renewed 1999 and 2007.
Morrow AL, Meinzen-Derr J, Huang P, Schibler KR, Cahill T, Keddache M, Kallapur SG, Newburg DS, Tabangin M, Warner BB, Jiang X. Fucosyltransferase 2 Non-Secretor and Low Secretor Status Predicts Severe Outcomes in Premature Infants. J Pediatr. 2011 Jan 20. Johnson RF, Cohen AP, Guo Y, Schibler K, Greinwald JH. Genetic mutations and aminoglycoside-induced ototoxicity in neonates. Otolaryngol Head Neck Surg. 2010 May;142(5):704-7. Olsen IE, Lawson ML, Meinzen-Derr J, Sapsford AL, Schibler KR, Donovan EF, Morrow AL. Use of a body proportionality index for growth assessment of preterm infants. J Pediatr. 2009 Apr;154(4):486-91. Lavery AP, Meinzen-Derr JK, Anderson E, Ma Q, Bennett MR, Devarajan P, Schibler KR. Urinary NGAL in premature infants. Pediatr Res. 2008 Oct;64(4):423-8.
Schibler KR, Georgelas A, Rigaa A. Developmental biology of the dendritic cell system. Acta Paediatr Suppl. 2002;91(438):9-16.
Schibler KR. Developmental Biology of the Hematopoietic Growth Factors. In Fetal and Neonatal Physiology. Polin RA, Fox WW, eds. Philadelphia: WB Saunders, 2009.Schibler KR. The Mononuclear Phagocyte System. In Fetal and Neonatal Physiology. Polin RA, Fox WW, eds. Philadelphia: WB Saunders, 2009.Donovan E, Greenberg J, Habernman B, Narendran V, Schibler K, Warner B. Neonatal Morbidities of Prenatal and Perinatal Origin. In Maternal-Fetal Medicine. Creasy RK, Resnik R and Iams JD., eds Philadelphia : WB Saunders, 2009.
The natural history of CMV-related hearing loss and the feasibility of CMV screening as adjunct to hearing in the newborn. Co-investigator. National Institutes of Health. Jan 2006 - Dec 2012. #HHS-N-260200500008C.
Novel genetic and salivary glycan biomarkers for risk of NEC in ELBW infants. Co-Principal Investigator. National Institutes of Health. Mar 2009 - Feb 2014. #R01-HD059140.
Kelley Shultz, MD Staff Physician, Neonatology
Staff Physician, Neonatology
MD: Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, NC, 1986.
Residency: Nationwide Children’s Hospital, Columbus, OH, 1989.
Certification: Board Certified, American Board of Pediatrics, 1990 to current.
Andrew Patrick South, MD, MPH Attending Neonatologist
MD: Case Western Reserve University, Cleveland, OH, 2000.
Residency: Pediatrics, University of North Carolina Children’s Hospital, Chapel Hill, NC.
Fellowship: Neonatology, University of North Carolina Children’s Hospital, Chapel Hill, NC.
Slaughter JL, Pakrashi T, Jones DE, South AP, Shah TA. Echocardiographic detection of pulmonary hypertension in extremely low birth weight infants with bronchopulmonary dysplasia requiring prolonged positive pressure ventilation. J Perinatol. 2011 Feb 10.
South AP, Wessel JJ, Sberna A, Patel M, Morrow AL. Hospital readmission among infants with gastroschisis. J Perinatol. 2011 Feb 10.
South AP, Jones DE, Hall ES, Huo S, Meinzen-Derr J, Liu L, Greenberg JM. Spatial Analysis of Preterm Birth Demonstrates Opportunities for Targeted Intervention. Matern Child Health J. 2011 Feb 3.
Winik BC, Asial RA, McGrath JA, South AP, Boente MC. Acantholytic ectodermal dysplasia: clinicopathological study of a new desmosomal disorder. Br J Dermatol. 2009 Apr;160(4):868-74.
South AP, Marshall DD, Bose CL, Laughon MM. Growth and neurodevelopment at 16 to 24 months of age for infants born with gastroschisis. J Perinatol. 2008 Oct;28(10):702-6.
South MMT, Strauss RA, South AP, Boggess JF, Thorp JM. The use of non-nutritive sucking to decrease the physiologic pain response during neonatal circumcision: A randomized controlled trial. Am J of Obstet and Gynec 2005;193:537-43.Grischkan J, Storfer-Isser A, Rosen CL, Larkin EK, Kirchner HL, South A, Wilson-Costello DC, Martin RJ, Redline S. Variation in childhood asthma among former preterm infants. J Pediatr 2004;144:321-6.
Christina J. Valentine, MD Attending Neonatologist
Maternal / infant nutrition, human milk
Christina J. Valentine, MD, MS, RD, FAAP, is currently a neonatologist, assistant professor and principal investigator in the Division of Neonatology, Perinatal and Pulmonary Biology at Cincinnati Children’s Hospital Medical Center in the Center for Interdisciplinary Research in Human Milk and Lactation. She has worked in the field of neonatal nutrition for the past 24 years and has published papers, textbook chapters and given lectures on maternal nutrition, human milk and neonatal nutrition.
Her graduate degree was done at the University of Florida and focused on premature infant nutrition and carnitine in the premature piglet model. Her medical school and Pediatric Residency training was at Baylor College of Medicine in Houston, TX where she was fortunate to work on her hind milk feeding study and more basic science work in oxidative metabolites through an Alpha omega Alpha research fellowship. She completed her Neonatology Fellowship and a recent Randomized Clinical Trial with maternal supplementation at The Ohio State University / Nationwide Children’s Hospital. She currently has research funding through the Research Institute and as a co-investigator on RO1 NIH funding to investigate clinical strategies to boost maternal nutrition and DHA supplementation for improving maternal and infant immune and metabolic health to reduce prematurity related complications and works closely with her mentor Ardythe Morrow, PhD, on biomarkers and gene expression relationships at Cincinnati Children's and Lynette Rogers, PhD, at her former institution, Nationwide Children’s and The Ohio State on DHA effects on inflammation signaling events.
MD: Baylor College of Medicine, Houston, TX, 1999.
Residency: Pediatrics, Baylor College of Medicine / Texas Children’s Hospital, Houston, TX, 2002.
Neonatal-Perinatal Fellowship:The Ohio State University / Nationwide Children’s Hospital, Columbus, OH, 2010.
MS:Human Nutrition, The University of Florida, Gainesville , FL, 1988.
Valentine CJ. Maternal Dietary Docosahexaenoic Acid (DHA) and Immune Homeostasis in the Preterm Infant. Adv Nutr. 2012.
Valentine CJ, Morrow G, Pennell M, Hodge A, Collins K, Haban-Bartz, A, Morrow A, Rogers L. Randomized controlled trial of Docosahexaenoic Acid supplementation in Midwestern U.S. Human Milk Donors. Breastfeeding Medicine. 2012.
Rogers L, Valentine CJ, Pennell M, et al. Maternal Docosahexaenoic acid supplementation decreases lung inflammation in hyperoxia-exposed newborn mice. J Nutr. 2011;141:214-22.
Valentine CJ, Morrow G, Fernandez S, Gulati P, Bartholamew D, Long D, Welty S, Rogers L. Docosahexaenoic Acid and Free Amino acids are low in Pasteurized Donor Milk for the Preterm Infant. J Pediatr. 2010;157:906-10.
Valentine CJ , Fernandez S, Rogers LK,et al. Early Amino Acids Improve Growth in The Preterm Infant. J Perinatol. 2009;29:428-432.
Valentine CJ, Puthoff T. Enhancing Parenteral Nutrition Therapy for the Neonate. Nutrition in Clinical Practice. 2007;22:183-193.
Hurst N, Valentine CJ, Burns P, Kirsten L. Skin-to-skin holding low birth weight infants enhances maternal milk volume. J Perinatol. 1997;17:213- 17.Valentine CJ, Hurst NM, Schanler RJ. Hindmilk improves weight gain in low birth weight infants fed human milk. J Pediatr Gastroenterol Nutr. 1994;18:474-477.
Meetze W, Valentine CJ, McGuigan JE, Conlon M, Sacks N, Neu J. Gastrointestinal priming prior to full enteral nutrition in very low birth weight infants. J Pediatr Gastroenterol Nutr. 1992;15:163-170.
Neu J, Valentine CJ, Meetze W. Scientifically based strategies for nutrition of the high risk low birth weight infant. Eur J Ped. 1990;150:2-13.
Laura Placke Ward, MD
Multidisciplinary quality improvement; family centered care; evidence-based practice
Strategies to prevent significant hyperbilirubinemia in infants
Dr. Ward has been a neonatologist in the division since 2002, and attends at The University Hospital.
Kathy E. Wedig-Stevie, MD Medical Director, High Risk Follow-up Clinic at Good Samaritan Hospital
Medical Director, High Risk Follow-up Clinic at Good Samaritan Hospital
Neonatologist, Good Samaritan Hospital
Medical Director, Mercy Hospital Fairfield Nurseries
MD: University of Cincinnati Medical School, Cincinnati, Ohio, 1978.Residency: Pediatrics, University of Cincinnati Medical Center, Cincinnati, Ohio, 1978-1981.
Fellowship: Neonatology, University Hospitals: Rainbow Babies and Children's Hospital, Case Western Reserve University, Cleveland, Ohio, 1983.Certifications: Pediatrics, 1983; Neonatology, 1983.
Scott L. Wexelblatt, MD Medical Director, Regional Newborn Services
Medical Director, Regional Newborn Services
Jonathan R. Wispe, MD Attending Neonatologist
Diane K. Donley, MD Staff Physician, Neonatology
Teen pregnancy; parent education
Joshua C. Euteneuer, MD Clinical Fellow, Division of Neonatology
Clinical Fellow, Division of Neonatology
MD: University of Nebraska Medical Center, Omaha, NE, 2010.
Residency: Pediatrics, Washington University in St. Louis/St. Louis Children's Hospital, St. Louis, MO, 2013.
Michelle L. French, MD Staff Physician, Neonatology
Jennifer B. Hardie, MD Staff Physician
Jillian A. Klein, MD Staff Physician
Jennifer Lewis, CNP Nurse Practitioner, Division of Neonatology
Nurse Practitioner, Division of Neonatology
M. Katherine Loudermilk, MD Pediatrician
Jennifer McAllister, MD Staff Physician, Neonatology and Pulmonary Medicine
Staff Physician, Neonatology and Pulmonary Medicine
MD: University of Toledo College of Medicine, Toledo, OH, 2007.
Residency: Pediatrics, University of Michigan Mott Children's Hospital, Ann Arbor, MI, 2010.
Certification: Pediatrics, 2010.
Alisa O. McGill, MD Staff Physician, Neonatology
Miriam Y. Peri, MD Moonlighter, Department of Neonatology and Pulmonary Biology
Moonlighter, Department of Neonatology and Pulmonary Biology
Deborah K. Rufner, MD Staff Physician, Neonatology
MD: The Ohio State University, Columbus, OH, 1975.
Residency: Naval Regional Medical Center, San Diego, CA, 1978.
Certification: American Board of Pediatrics, 1980.
Augusto F. Schmidt, MD, PhD Clinical Fellow, Division of Neonatology
Dr. Schmidt chose Cincinnati Children's Hospital Medical Center because it offers great clinical experience in a very supportive and nurturing environment.
MD: Universidade Estadual de Campinas, Brazil, 2007.
PhD: Universidade Estadual de Campinas, Brazil, 2010.
Residency: Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2013.
Laura M. Seske, MD Clinical Fellow, Division of Neonatology
MD: University of Illinois, Chicago, IL, 2010.
Residency: Washington University, St. Louis Children's Hospital, St. Louis, MO, 2013.
Wambui Waruingi, MD Staff Neonatologist, Neonatology and Pulmonary Biology
Staff Neonatologist, Neonatology and Pulmonary Biology
MD: University of Nairobi, College of Health Sciences, 1996.
Residency: Internal Medicine/ Pediatrics, Case Western Reserve university, MetroHealth Medical Center.
Certification: Internal medicine 2009, Pediatrics 2010.
Fellowship: Neonatology, Case Western Reserve University/ Cleveland Clinic, 2012.
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