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Director

Prasad Devarajan, MD
Louise M. Williams Endowed Chair

513-636-4531

prasad.devarajan@cchmc.org

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Prasad Devarajan, MD

Louise M. Williams Endowed Chair

Director, Nephrology and Hypertension

Professor, UC Department of Pediatrics

Phone: 513-636-4531

Fax: 513-636-7407

Email: prasad.devarajan@cchmc.org

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Specialties

Visit the Devarajan Lab.

Education and Training

Premedical Studies: Bombay University, India, 1979.

MD: Bombay University, India, 1985.

Publications

View PubMed Publications

Czech KA, Bennett M, Devarajan P. Distinct metalloproteinase excretion patterns in focal segmental glomerulosclerosis. Pediatr Nephrol. 2011 Jul 1.

Askenazi DJ, Koralkar R, Levitan EB, Goldstein SL, Devarajan P, Khandrika S, Mehta RL, Ambalavanan N. Baseline Values of Candidate Urine Acute Kidney Injury (AKI) Biomarkers Vary by Gestational Age in Premature Infants. Pediatr Res. 2011 Jun 3.

Abraham BP, Frazier EA, Morrow WR, Blaszak RT, Devarajan P, Mitsnefes M, Bryant JC, Sachdeva R. Cystatin C and neutrophil gelatinase-associated lipocalin as markers of renal function in pediatric heart transplant recipients. Pediatr Transplant. 2011 Apr 25.

Sundaram N, Bennett M, Wilhelm J, Kim MO, Atweh G, Devarajan P, Malik P. Biomarkers for early detection of sickle nephropathy. Am J Hematol. 2011 Jul;86(7):559-66.

Devarajan P, Krawczeski C. In reply to 'antifibrinolytic use during cardiac and hepatic surgery makes tubular proteinuria-based early biomarkers poor tools to diagnose perioperative acute kidney injury'. Am J Kidney Dis. 2011 Jun;57(6):960-1.

Piyaphanee N, Ma Q, Kremen O, Czech K, Greis K, Mitsnefes M, Devarajan P, Bennett MR. Discovery and initial validation of α 1-B glycoprotein fragmentation as a differential urinary biomarker in pediatric steroid-resistant nephrotic syndrome. Proteomics Clin Appl. 2011 Jun;5(5-6):334-42.

Li S, Krawczeski CD, Zappitelli M, Devarajan P, Thiessen-Philbrook H, Coca SG, Kim RW, Parikh CR; for the TRIBE-AKI Consortium. Incidence, risk factors, and outcomes of acute kidney injury after pediatric cardiac surgery: A prospective multicenter study. Crit Care Med. 2011 Jun;39(6):1493-1499.

Krawczeski CD, Woo JG, Wang Y, Bennett MR, Ma Q, Devarajan P. Neutrophil gelatinase-associated lipocalin concentrations predict development of acute kidney injury in neonates and children after cardiopulmonary bypass. J Pediatr. 2011 Jun;158(6):1009-1015.e1.

Basu RK, Devarajan P, Wong H, Wheeler DS. An update and review of acute kidney injury in pediatrics. Pediatr Crit Care Med. 2011 May;12(3):339-47.

Devarajan P. Biomarkers for the early detection of acute kidney injury. Curr Opin Pediatr. 2011 Apr;23(2):194-200.

Grants

Research Training in Pediatric Nephrology 0.6 calendar months. Principal Investigator. National Institute of Diabetes and Digestive and Kidney Diseases. Jul 2007 - Jun 2012.

Biomarkers of renal injury in cardiac surgery 1.2 calendar months. Principal Investigator. National Heart, Lung and Blood Institute. Jul 2007 - Jun 2012.

Long term outcomes of AKI after cardiac surgery 0.6 calendar months. Principal Investigator. National Institute of Diabetes and Digestive and Kidney Diseases. Sep 2008 - Aug 2013.

Faculty

Michael R. Bennett, PhD
Director, Biomarker Laboratory

513-636-8349

michael.bennett@cchmc.org

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Michael R. Bennett, PhD

Director, Biomarker Laboratory

Assistant Professor, UC Department of Pediatrics

Phone: 513-636-8349

Email: michael.bennett@cchmc.org

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Specialties

Diagnostic markers for pediatric diseases; acute kidney injury; nephrotic syndrome, lupus nephritis; focal segmental glomerulosclerosis; mechanisms of neurologic disease

Education and Training

Research Fellowship: Cincinnati Children's Hospital Medical Center, Cincinnati, OH

PhD: University of Cincinnati College of Medicine, Cincinnati, OH, 2004.

BA: Thomas More College, Crestview Hills, KY, 1997.

Publications

View PubMed Publications

Krawczeski C, Vandevoorde R, Kathman T, Bennett M, Woo J, Wang Y, Griffiths R, Devarajan P. Serum Cystatin C Is an Early Predictive Biomarker of Acute Kidney Injury after Pediatric Cardiopulmonary Bypass. CJASN. 2010; 2010 Sep;5(9):1552-7.

Bagshaw SM, Bennett M, Haase M, Haase-Fielitz A, Egi M, Morimatsu H, D'amico G, Goldsmith D, Devarajan P, Bellomo R. Plasma and urine neutrophil gelatinase-associated lipocalin in septic versus non-septic acute kidney injury in critical illness. Intensive Care Med. 2009;36(3):381-4

Stella CL, Bennett MR, Devarajan P, Greis K, Wyder M, Macha S, Rao M, Jodicke C, Moussa H, How HY, Myatt L, Webster R, Sibai BM. Preterm labor biomarker discovery in serum using 3 proteomic profiling methodologies. Am J Obstet Gynecol. 2009;201(4):387.e1-13.

Haase M, Bellomo R, Devarajan P, Ma Q, Bennett MR, Möckel M, Matalanis G, Dragun D, Haase-Fielitz A. Novel biomarkers early predict the severity of acute kidney injury after cardiac surgery in adults. Ann Thorac Surg. 2009;88(1):124-30

Haase-Fielitz A, Bellomo R, Devarajan P, Bennett M, Story D, Matalanis G, Frei U, Dragun D, Haase M. The predictive performance of plasma neutrophil gelatinase-associated lipocalin (NGAL) increases with grade of acute kidney injury. Nephrol Dial Transplant. 2009;24:3349-3354.

Bennett M, Ravipati N, Ross G, Nguyen M, Hirsch R, Beekman R, Rovner L, Devarajan P. Using proteomics to identify pre-procedural risk factors for contrast induced nephropathy. Proteomics – Clinical Applications. 2008;2(7-8):1058-1064.

Koyner JL, Bennett MR, Worcester EM, Ma Q, Raman J, Jeevanandam V, Kasza KE, O'Connor MF, Konczal DJ, Trevino S, Devarajan P, Murray PT. Urinary cystatin C as an early biomarker of acute kidney injury following adult cardiothoracic surgery. Kidney Int. 2008;74(8):1059-1069.

Lavery AP, Meinzen-Derr JK, Anderson E, Ma Q, Bennett MR, Devarajan P, Schibler KR. Urinary NGAL in premature infants. Pediatr Res. 2008;64(4):423-8.

Bennett M, Dent C, Ma Q, Dastrala S, Grenier F, Workman R, Syed H, Ali S, Barasch J, Devarajan P. Urine NGAL predicts acute kidney injury, morbidity and mortality after cardiac surgery: a prospective study. Clinical Journal of the American Society of Nephrology. 2008;3(3): 665-673.

Bennett M, Czech K, Arend L, Witte D, Devarajan P, Potter, S. Analysis of the glomerular gene expression profile in patients with focal segmental glomerulosclerosis. Experimental Nephron. 2007;107(1): e30-40

Suzuki M, Ross GF, Wiers K, Nelson S, Bennett MR, Passo MH, Devarajan P, Brunner HI. Identification of a urinary proteomic signature for lupus nephritis. Pediatric Nephrology. 2007;22(12): 2047-2057.

John J. Bissler, MD
Associate Program Director for Research and Academic Careers

513-636-1201

john.bissler@cchmc.org

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John J. Bissler, MD

Associate Program Director for Research and Academic Careers

Clark D. West Chair of Nephrology

Director, Nephrology Fellowship Training Program

Professor, UC Department of Pediatrics

Phone: 513-636-1201

Fax: 513-636-7407

Email: john.bissler@cchmc.org

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Specialties

Clinical Interests

Proliferative renal diseases; renal cystic disease; solid lesions

Research Interests

Proliferative renal diseases; polycystic kidney disease; tuberous sclerosis complex; Von Hippel-Lindau disease; Birt-Hogg-Dube syndrome and renal cancers; understanding the mechanisms of mutation leading to these diseases as well as the consequences of mutations in hope of finding effected treatments

Visit the Bissler Lab.

Education and Training

MD: Northeastern Ohio University College of Medicine, Rootstown, OH, 1985

Residency: Pediatrics, Children's Medical Center, Akron, OH

Fellowship: Nephrology, Children's Hospital Medical Center, Cincinnati, OH

Certification: Pediatrics, 1989; Pediatric Nephrology, 1992

Publications

View PubMed Publications

Dixon BP, Hulbert JC, and Bissler JJ. Tuberous Sclerosis Complex Renal Disease. Nephron. 2011;118(1):e15-20.

Siroky BJ, Yin H, Bissler JJ. Molecular Insights into Tuberous Sclerosis Complex Renal Disease. Pediatric Nephrol. 2010 Dec 9.

Mrug M, and Bissler JJ. Simulation of real-time ultrasound-guided renal biopsy. Kidney Int. 2010 Oct;78(7):705-7.

Bissler JJ, Siroky BJ, Yin H. Glomerulocystic kidney disease. Pediatric Nephrol. 2010 Oct;25(10):2049-56; quiz 2056-9.

Liu G, Bissler JJ, Sinden RR, Leffak M. Replication dependent instability at (CTG)•(CAG) repeat hairpins in human cells. Nat Chem Biol. 2010 Sep;6(9):652-9.

Johnson SR, and the Review Panel of the European Respiratory Society Lymphangioleiomyomatosis Task Force. European Respiratory Society guidelines for the diagnosis and management of lymphangioleiomyomatosis. Eur Respir J. 2010;35:14-26.

Siroky BJ, Czyzyk-Krzeska MF, Bissler JJ. Renal involvement in tuberous sclerosis complex and von Hippel-Lindau disease: shared disease mechanisms? Nat Clin Pract Nephrol. 2009;5(3):143-56.

Schmithorst VJ, Altes TA, Young LR, Franz DN, Bissler JJ, McCormack FX, et al. Automated algorithm for quantifying the extent of cystic change on volumetric chest CT: initial results in Lymphangioleiomyomatosis . Am J Roentgenol. 2009;192(4):1037-44.

Dixon BP, Chu A, Henry J, Kim R, Bissler JJ. Increased cancer risk of augmentation cystoplasty: Possible role for hyperosmolal microenvironment on DNA damage recognition . Mutat Res. 2009; 670:88-95.

Book Chapters

Bissler JJ, Henske E. Tuberous Sclerosis Complex: From Genes to Therapeutics. Chapter 15. Renal Manifestations of Tuberous Sclerosis Complex. In: Whittemore V, Henske EP, Kwiatkowski D, editors. New York: Elsevier; 2009.

Grants

Placebo-Controlled Randomized Multicenter mTOR Inhibitor Trial for Angiomyolipomata. Principal Investigator. Jun 2006 – Jun 2014.

Bradley P. Dixon, MD

513-636-4531

bradley.dixon@cchmc.org

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Bradley P. Dixon, MD

Assistant Professor, UC Department of Pediatrics

Phone: 513-636-4531

Fax: 513-636-7407

Email: bradley.dixon@cchmc.org

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Specialties

DNA damage response; DNA repair; biology of bladder augmentation; atypical hemolytic uremic syndrome

Biography

Bradley Dixon, MD, joined the faculty in the Division of Nephrology and Hypertension at Cincinnati Children's in 2006. He has received support for his research from a William Cooper Procter Pediatric Research Award in 2006, a Child Health Research Career Development Award (K12) in 2009, and is currently funded by a K08 through the National Institute of Diabetes, Digestive and Kidney Diseases. Dr. Dixon’s research interests focus on the effects of hyperosmolal microenvironments such as the renal medulla and urinary bladder upon vital cellular processes such as the DNA damage response pathway and activation of cell cycle checkpoints and apoptosis. This research focus attempts to understand the susceptibility of the gastrointestinal tissues used in bladder reconstructions to carcinogenesis.

In addition to his basic science research interests, Dr. Dixon has a clinical research interest in thrombotic microangiopathies such as atypical hemolytic uremic syndrome (aHUS) and thrombotic thrombocytopenic purpura (TTP), and is an investigator in a number of clinical trials and registries for these diseases. Dr. Dixon is also involved in clinical research studying cystic kidney diseases such as tuberous sclerosis complex (TSC) and autosomal dominant polycystic kidney disease (ADPKD).

Dr. Dixon is the assistant program director for the Pediatric Nephrology Fellowship Training Program, serves in an advisory capacity to the Adaptive Care Team, and on the Board of the Cincinnati Pediatric Society, most recently as president in 2011.

Education and Training

BA: College of Wooster, Wooster, OH, 1995.

MD: University of Tennessee, Memphis, 1999.

Residency: Cincinnati Children's Hospital Medical Center, 1999-2002.

Chief Residency: Cincinnati Childrens Hospital, 2002-2003.

Fellowship: Cincinnati Childrens Hospital, 2003-2006.

Publications

View PubMed Publications

Dixon BP, Henry J, Siroky BJ, Chu A, Groen PA, Bissler JJ. Cell Cycle Control and DNA Damage Response of Conditionally Immortalized Urothelial Cells. PLoS ONE. 2011 Jan 28;6(1):e16595.

Dixon BP, Hulbert JC, Bissler JJ. Tuberous sclerosis complex renal disease. Nephron Exp Nephrol. 2011;118(1):e15-20.

Lo MM, Mo JQ, Dixon BP, Czech KA. Disseminated histoplasmosis associated with hemophagocytic lymphohistiocytosis in kidney transplant recipients. Am J Transplant. 2010 Mar;10(3):687-91.

Dixon BP, Chu A, Henry J, Kim R, Bissler JJ. Increased cancer risk of augmentation cystoplasty: possible role for hyperosmolal microenvironment on DNA damage recognition. Mutat Res. 2009 Nov 2;670(1-2):88-95.

Dixon BP, Lu L, Chu A, Bissler JJ. RecQ and RecG helicases have distinct roles in maintaining the stability of polypurine.polypyrimidine sequences. Mutat Res. 2008 Aug 25;643(1-2):20-8.

Dixon BP, McEnery P, Goebel J. Immunobiology of paediatric renal transplantation. Progress in Paediatric Urology. 2008;10:165-182.

Bissler JJ, Dixon BP. A mechanistic approach to inherited polycystic kidney disease. Pediatr Nephrol. 2005 May;20(5):558-66.

Dixon BP, Devarajan P, Mitsnefes M. Neonatal renovascular hypertension due to prenatal traumatic retroperitoneal hematoma. Pediatr Nephrol. 2005 May;20(5):670-2.

Grants

DNA Damage and Response in the Bladder Microenvironment. Principal Investigator. National Institutes of Health. Jul 2011 - Apr 2015. #K08 DK081737.

Jens W. Goebel, MD
Clinical Director, Nephrology and Hypertension

513-636-4531

jens.goebel@cchmc.org

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Jens W. Goebel, MD

Clinical Director, Nephrology and Hypertension

Medical Director, Kidney Transplantation

Clinical Director, Kidney Transplantation

Associate Professor, UC Department of Pediatrics

Phone: 513-636-4531

Fax: 513-636-7407

Email: jens.goebel@cchmc.org

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Specialties

Clinical Interests

Organ transplantation in children

Research Interests

Transplant-relevant immunology

Biography

Dr. Goebel was recruited by Cincinnati Children's Hospital Medical Center in 2002 from the University of Kentucky to enhance the institution's kidney transplant program. His efforts along these lines focus both on further improving the clinical care of pediatric kidney transplant recipients and their families, as well as advancing basic and translational investigations into immunological aspects especially relevant to the field of transplantation.

Education and Training

MD: University of Heidelberg (Germany), 1991.

Residency and Chief Residency: Department of Pediatrics, University of South Alabama, Mobile, AL, 1991 to 1995.

Fellowship: Section of Pediatric Nephrology, Tulane University Medical Center, New Orleans, LA, 1995 to 1998

Certifications: General Pediatrics, 1994, 2002; Pediatric Nephrology, 1999.

Publications

View PubMed Publications

Sanchez-Pinto LN, Laskin BL, Jodele S, Hummel TR, Yin HJ, Goebel J. BK virus nephropathy in a pediatric autologous stem-cell transplant recipient. Pediatr Blood Cancer. 2011 Mar;56(3):495-7.

Hooper DK, Carle AC, Schuchter J, Goebel J. Interaction between tacrolimus and intravenous nicardipine in the treatment of post-kidney transplant hypertension at pediatric hospitals. Pediatr Transplant. 2011 Feb;15(1):88-95.

Sherwin CM, Fukuda T, Brunner HI, Goebel J, Vinks AA. The evolution of population pharmacokinetic models to describe the enterohepatic recycling of mycophenolic acid in solid organ transplantation and autoimmune disease. Clin Pharmacokinet. 2011 Jan 1;50(1):1-24.

Campbell K, Ng V, Martin S, Magee J, Goebel J, Anand R, Martz K, Bucuvalas J; SPLIT Renal Function Working Group. Glomerular filtration rate following pediatric liver transplantation--the SPLIT experience. Am J Transplant. 2010 Dec;10(12):2673-82.

Pai AL, Gray E, Kurivial K, Ross J, Schoborg D, Goebel J. The Allocation of Treatment Responsibility scale: a novel tool for assessing patient and caregiver management of pediatric medical treatment regimens. Pediatr Transplant. 2010 Dec;14(8):993-9.

Jodele S, Bleesing JJ, Mehta PA, Filipovich AH, Laskin BL, Goebel J, Pinkard SL, Davies SM. Successful early intervention for hyperacute transplant-associated thrombotic microangiopathy following pediatric hematopoietic stem cell transplantation. Pediatr Transplant. 2010 Nov 5.

Pai AL, Ingerski LM, Perazzo L, Ramey C, Bonner M, Goebel J. Preparing for transition? The allocation of oral medication regimen tasks in adolescents with renal transplants. Pediatr Transplant. 2011 Feb;15(1):9-16.

Laskin BL, Goebel J, Davies SM, Khoury JC, Bleesing JJ, Mehta PA, Filipovich AH, Paff ZN, Lawrence JM, Yin HJ, Pinkard SL, Jodele S. Early clinical indicators of transplant-associated thrombotic microangiopathy in pediatric neuroblastoma patients undergoing auto-SCT. Bone Marrow Transplant. 2010 Aug 9.

Herzer M, Goebel J, Cortina S. Transitioning cognitively impaired young patients with special health needs to adult-oriented care: collaboration between medical providers and pediatric psychologists. Curr Opin Pediatr. 2010 Oct;22(5):668-72.

Fukuda T, Goebel J, Thøgersen H, Maseck D, Cox S, Logan B, Sherbotie J, Seikaly M, Vinks AA. Inosine Monophosphate Dehydrogenase (IMPDH) Activity as a Pharmacodynamic Biomarker of Mycophenolic Acid Effects in Pediatric Kidney Transplant Recipients. J Clin Pharmacol. 2010 Apr 23.

Grants

Center-PI / Co-Investigator / Collaborator:

NIH UO1 grant: Noninvasive Monitoring to Predict Outcome in de novo Kidney Transplant Recipients (CTOT-01, Protocol Chair: P. Heeger, MD, City), commenced in late 2005 and ongoing

NIH UO1 grant: Health and Literacy in Child and Adult Assessment: Expanded Testing of the Pediatric PROMIS (Patient Reported Outcomes Measurement Information System) Tool (Sponsor: D. DeWalt, MD, MPH, ), ongoing

NIH UO1 grant: Chronic Kidney Disease in Children (CKID, PI: B. Warady, MD, Children’s Mercy Hospital, Kansas City, MO), ongoing

NIH RO1 grant: Calcineurin Inhibitor Minimization And Foxp3+ Tregs Post-Transplant (PIs: Wayne Hancock, MD, Children’s , and John Bucuvalas, MD, Cincinnati Children’s Hospital), ongoing

Midwest Pediatric Nephrology Consortium: Assessing and Implementing Transition to Adult Care in Children with CKD (PI: M. Ferris, MD, MPH, PhD, ), ongoing

Amgen Pharmaceuticals: Pediatric Anemia Correction Study (Protocol 20050256), ongoing

Roche Pharmaceuticals: Development of Population Pharmacokinetic models of Mycophenolic Acid for use in Bayesian Dose Individualization in Pediatric Kidney Transplant Patients (PI: A. Vinks, Cincinnati Children’s Hospital), ongoing

Cincinnati Children’s Hospital Medical Center Outcomes Research Award: Validation of a Real-Time Adherence Assessment System (PI: A. Pai, PhD, Cincinnati Children’s Hospital), ongoing

Cincinnati Children’s Hospital Medical Center Translational Research Initiative grant: Pharmacogenetics of Mycophenolic Acid in Kidney Transplant Patients (PI: A. Vinks, Cincinnati Children’s Hospital), ongoing

Cincinnati Children’s Hospital Medical Center Translational Research Initiative grant: Biomarkers for Patient-tailored Therapies in Pediatric Lupus Nephritis using Mycophenolic Acid (PI: H. Brunner, Cincinnati Children’s Hospital), ongoing

Cincinnati Children’s Hospital Medical Center Translational Research Initiative grant: Pharmacogenetics of IMPDH in Kidney Transplant Patients (PI: A. Vinks, Cincinnati Children’s Hospital), ongoing

Stuart L. Goldstein, MD
Director, Center for Acute Care Nephrology

513-803-3295

stuart.goldstein@cchmc.org

High Res

Stuart L. Goldstein, MD

Director, Center for Acute Care Nephrology

Professor, UC Department of Pediatrics

Phone: 513-803-3295

Fax: 513-636-6407

Email: stuart.goldstein@cchmc.org

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Specialties

Clinical Interests

Acute kidney injury; continuous renal replacement therapy; end-stage renal disease; health-related quality of life

Research Interests

Acute kidney injury epidemiology and biomarkers; health-related quality of life in ESRD; cardiovascular complications and inflammation in ESRD

Biography

Stuart L. Goldstein, MD has been an active investigator in the field of pediatric acute kidney injury (AKI) since 2000. Dr. Goldstein's main research foci include AKI epidemiology and outcomes, acute renal replacement therapy provision and investigation of novel urinary AKI biomarkers in the pediatric population. Dr. Goldstein has a strong record of interdisciplinary and inter-institutional collaboration, evidenced by his establishment and directing of the Prospective Pediatric Continuous Renal Replacement Therapy (ppCRRT) and its success as well as collaboration with critical care physicians, cardiologists and emergency medicine physicians to study AKI in their populations.

This collaboration includes publication of the first article demonstrating the existence of a cardio-renal syndrome in pediatric patients with acute decompensated heart failure. Dr. Goldstein has also performed the only published assessment of novel urinary AKI biomarkers in a heterogeneous group of critically ill children, demonstrating their accuracy to predict AKI development and severity. Dr. Goldstein has been developing a program to investigate and minimize nephrotoxic medication associated AKI in non-critically ill children.

Education and Training

MD: Columbia College of Physicians and Surgeons, New York, NY, 1990.

Residency: Baylor College of Medicine, Houston, TX.

Fellowship: Pediatric Nephrology, Children's Hospital, Boston, MA.

Publications

View PubMed Publications

Goldstein SL, Devarajan P. Acute kidney injury in childhood: should we be worried about progression to CKD? Pediatr Nephrol. 2011 Apr;26(4):509-22.

Du Y, Zappitelli M, Mian A, Bennett M, Ma Q, Devarajan P, Mehta R, Goldstein SL. Urinary biomarkers to detect acute kidney injury in the pediatric emergency center. Pediatr Nephrol. 2011 Feb;26(2):267-74.

Moffett BS, Goldstein SL, Adusei M, Kuzin J, Mohan P, Mott AR. Risk factors for postoperative acute kidney injury in pediatric cardiac surgery patients receiving angiotensin-converting enzyme inhibitors. Pediatr Crit Care Med. 2011 Feb 10.

Zappitelli M, Moffett BS, Hyder A, Goldstein SL. Acute kidney injury in non-critically ill children treated with aminoglycoside antibiotics in a tertiary healthcare centre: a retrospective cohort study. Nephrol Dial Transplant. 2011 Jan;26(1):144-50.

Koralkar R, Ambalavanan N, Levitan EB, McGwin G, Goldstein S, Askenazi D. Acute Kidney Injury Reduces Survival in Very Low Birth Weight Infant. Pediatr Res. 2010 Dec 20.

Goldstein SL. Continuous renal replacement therapy: mechanism of clearance, fluid removal, indications and outcomes. Curr Opin Pediatr. 2010 Dec 21.

Goldstein SL. Urinary kidney injury biomarkers and urine creatinine normalization: a false premise or not? Kidney Int. 2010 Sep;78(5):433-5.

Goldstein SL, Chawla L. Renal Angina. Clin J AmSoc Nephrol. 2010 May;5(5):943-9.

Sutherland SM, Zappitelli M, Alexander SR, Chua AN, Brophy PD, Bunchman TE, Hackbarth R, Somers MJG, Baum M, Symons JM, Flores FX, Benfield M, Askenazi D, Chand D, Fortenberry JD, Mahan JD, McBryde K, Blowey D, Goldstein SL. Fluid Overload and Mortality in Children Receiving Continuous Renal Replacement Therapy: The Prospective Pediatric Continuous Renal Replacement Therapy Registry. Am J Kidney Dis. 2010 Feb;55(2):316-25.

Grants

PlasmaLyte Gastroenteritis Study. Principal Investigator. Baxter Healthcare. Nov 2010 - Oct 2011.

Inflammation, malnutrition and cardiac calcification in pediatric ESRD patients receiving dialysis- a comparison of hemodialysis vs. peritoneal dialysis. Principal Investigator. Baxter Healthcare. Dec 2010 - Dec 2011.

Optimize Fluid Dosing in Critically Ill Children with Acute Kidney Injury. Principal Investigator. Casey Lee Ball Foundation. Jan 2011 – Dec 2011.

Use of NGAL to Optimize Fluid Dosing, CRRT Initiation and Discontinuation in Critically Ill Children with Acute Kidney Injury. Principal Investigator. Casey Lee Ball Foundation. Feb 2011 - Jan 2012.

Evaluation of cystatin C and Urine Proteins as Early Biomarkers of AKI in Children Treated with Nephrotoxic Medication. Principal Investigator. The Research Institute of McGill University Health Centre. Jun 2011 – Jun 2012.

Center for Acute Care Nephrology Fellowship. Fellowship Director. Funded by Gambra Renal Products. Jan 2011 - Jan 2013.

Inflammation, malnutrition and cardiac calcification in pediatric ESRD patients receiving dialysis. Principal Investigator. Casey Lee Ball Foundation. Jan 2010 - Dec 2020.

David K. Hooper, MD, MS
Pediatric Nephrologist, Division of Nephrology and Hypertension

513-636-4531

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David K. Hooper, MD, MS

Pediatric Nephrologist, Division of Nephrology and Hypertension

Assistant Professor, UC Department of Pediatrics

Phone: 513-636-4531

Fax: 513-636-7407

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Specialties

Nephrology; kidney transplantation; quality improvement

Biography

Jointly appointed in the Division of Nephrology and Hypertension and the James M. Anderson Center for Health Systems Excellence at Cincinnati Children’s Hospital, Dr. Hooper's aim is to improve clinical outcomes for pediatric kidney transplant recipients through research in personalized care and the design of reliable healthcare systems.

Dr. Hooper's research training includes a Masters Degree in clinical and translational research from the University of Cincinnati, in addition to advanced training in quality improvement methodology through the Quality Scholars in Healthcare Transformation program at Cincinnati Children’s Hospital.

Dr. Hooper's career focus is to combine clinical outcomes research with quality improvement to reliably prevent cardiovascular disease, the leading cause of long-term death and disability in pediatric transplant recipients.

Education and Training

MD: University of Utah, Salt Lake City, Utah, 2003.

Residency: Cincinnati Children's Hospital, Cincinnati, Ohio, 2006.

Chief Residency: Cincinnati Children's Hospital, Cincinnati, Ohio, 2007.

MS: University of Cincinnati, Cincinnati, Ohio, 2010.

Fellowship: Cincinnati Children's Hospital, Cincinnati Ohio, 2010; Quality Scholar in Healthcare Transformation, James M. Anderson Center for Health Systems Excellence, Cincinnati Children's Hospital, Cincinnati, Ohio, 2011.

Certification: Pediatrics, 2006.

Publications

View PubMed Publications

Hooper DK, Kirby C, Margolis P, Goebel J. Reliable Individualized Monitoring Improves Cholesterol Control in Kidney Transplant Recipients. Pediatrics. Epub ahead of print. 2013.

Hooper DK, Williams JC, Carle AC, Amaral S, Chand DH, Ferris ME, Patel HP, Licht C, Barletta GM, Bastian V, Mitsnesfes M, Patel UD. The Quality of Cardiovascular Disease Care and Formal Transition for Adolescents with Kidney Disease. Pediatric Nephrology. Epub ahead of print. 2013.

Hooper DK, Fukuda T, Logan B, Gardiner R, Roy-Chaudhury A, Kirby C, Vinks A, Goebel J. Risk of Tacrolimus Toxicity in CYP3A5 Non-Expressors Treated with Intravenous Nicardipine After Kidney Transplantation. Transplantation. 2012 Apr;93(8):806-812.

Saldaña SN, Hooper DK, Froehlich TE, Campbell KM, Prows CA, Sadhasivam s, Nick TG, Seid M, Vinks AA, Glauser TA. Characteristics of Successful Recruitment in Prospective Pediatric Pharmacogenetic Studies. Clinical Therapeutics. 2011 Feb;15:88-95.

Hooper DK, Carle AC, Schuchter J, Goebel J. Interaction between tacrolimus and intravenous nicardipine in the treatment of post-kidney transplant hypertension at pediatric hospitals. Pediatr Transplant. 2011 Feb;15(1):88-95.

Kaplan HC, Brady PW, Dritz MC, Hooper DK, Linam WM, Froehle CM, Margolis P. The influence of context on quality improvement success in health care: a systematic review of the literature. Milbank Q. 2010 Dec;88(4):500-59.

Hooper DK. The Impact of CYP3A5 Genotype on the Interaction Between Tacrolimus and Intravenous Nicardipine in Kidney Transplant Recipients. University of Cincinnati. 2010 Aug 17.

Hooper DK, Hawkins JA, Fuller TC, Profaizer T, Shaddy RE. Panel-reactive antibodies late after allograft implantation in children. Ann Thorac Surg. 2005 Feb;79(2):641-4.

Raetz EA, Kim MK, Moos P, Carlson M, Bruggers C, Hooper DK, Foot L, Liu T, Seeger R, Carroll WL. Identification of genes that are regulated transcriptionally by Myc in childhood tumors. Cancer. 2003 Aug 15;98(4):841-53.

Lirazan MB, Hooper D, Corpuz GP, Ramilo CA, Bandyopadhyay P, Cruz LJ, Olivera BM. The spasmodic peptide defines a new conotoxin superfamily. Biochemistry. 2000 Feb 22;39(7):1583-8.

Grants

A Reliable System for Blood Pressure Control. Principal Investigator. KL2 Research Scholars (8KL2TR000078-04), Center for Clinical and Translational Science Training, University of Cincinnati. Apr 2012 - Mar 2014.

A Reliable System for Blood Pressure Control. Principal Investigator. Place Outcomes Research Award. James M. Anderson Center for Health Systems Excellence. Cincinnati Children’s Hospital Medical Center. Jul 2012 - Jun 2014.

Elizabeth C. Jackson, MD
Director, Healthy Bladder Clinic

513-636-4975

elizabeth.jackson@cchmc.org

High Res

Elizabeth C. Jackson, MD

Director, Healthy Bladder Clinic

Associate Professor, UC Department of Pediatrics

Phone: 513-636-4975

Fax: 513-636-6753

Email: elizabeth.jackson@cchmc.org

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Specialties

Functional bladder disorders; neurogenic bladder; urolithiasis

Biography

Elizabeth C. Jackson, MD, is a pediatric nephrologist recognized in the need for bladder management. Dr. Jackson has recently discontinued her inpatient nephrology role, and is currently focused on outpatient lower urinary tract management. She is the director of the Healthy Bladder Clinic at Cincinnati Children's. The Healthy Bladder Clinic cares for children with functional lower urinary tract disorders. There are more than 1200 visits per year to this clinic.

Education and Training

MD: University of Virginia, Charlottesville, Virginia, 1978.

Residency: Children's Hospital of Pittsburgh, Pittsburgh, PA, 1981.

Fellowship: Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, 1984.

Certification: Pediatrics, 1983; Pediatric Nephrology, 1985.

Publications

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Ivancić V, Defoor W, Jackson E, Alam S, Minevich E, Reddy P, Sheldon C. Progression of renal insufficiency in children and adolescents with neuropathic bladder is not accelerated by lower urinary tract reconstruction. J Urol. 2010 Oct;184(4 Suppl):1768-74.

DeFoor WR, Jackson E, Minevich E, Caillat A, Reddy P, Sheldon C, Asplin J. The risk of recurrent urolithiasis in children is dependent on urinary calcium and citrate. Urology. 2010 Jul;76(1):242-5.

DeFoor W, Clark C, Jackson E, Reddy P, Minevich E, Sheldon C. Risk factors for end stage renal disease in children with posterior urethral valves. J Urol. 2008 Oct;180(4 Suppl):1705-8; discussion 1708.

DeFoor W, Minevich E, Jackson E, Reddy P, Clark C, Sheldon C, Asplin J. Urinary metabolic evaluations in solitary and recurrent stone forming children. J Urol. 2008 Jun;179(6):2369-72.

DeFoor W, Asplin J, Jackson E, Jackson C, Reddy P, Sheldon C, Erhard M, Minevich E. Urinary metabolic evaluations in normal and stone forming children. J Urol. 2006 Oct;176(4 Pt 2):1793-6.

Defoor W, Asplin J, Jackson E, Jackson C, Reddy P, Sheldon C, Minevich E. Results of a prospective trial to compare normal urine supersaturation in children and adults. J Urol. 2005 Oct;174(4 Pt 2):1708-10.

Jensen S, Jackson EC, Riley L, Reddy S, Goebel J. Tacrolimus-based immunosuppression with steroid withdrawal in pediatric kidney transplantation -- 4-year experience at a moderate-volume center. Pediatr Transplant. 2003 7:119-124.

Strife CF, Prada AL, Clardy CW, Jackson E, Forristal J. Autoantibody to complement neoantigens in membranoproliferative glomerulonephritis. J Pediatr. 1990 May;116(5):S98-102.

Grants

Comparison of voice and buzzer alarms for nocturnal enuresis. Principal Investigator. Cincinnati Children's Hospital Medical Center. Oct 2011 - present.

Mark M. Mitsnefes, MD, MS
Pediatric Nephrologist

513-636-0125

mark.mitsnefes@cchmc.org

High Res

Mark M. Mitsnefes, MD, MS

Pediatric Nephrologist

Professor, UC Department of Pediatrics

Phone: 513-636-0125

Fax: 513-636-7407

Email: mark.mitsnefes@cchmc.org

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Specialties

Nephrology with focus on chronic kidney disease and hypertension

Biography

Mark Mitsnefes, MD, MS, is an established clinical investigator with expertise in the area of understanding the development of risk factors for cardiovascular disease in children with chronic kidney disease. The long-term goal of his research is to define biologic targets for interventions to prevent and slow progression of cardiovascular disease in children with chronic kidney disease.

Dr. Misnefes has received numerous awards, including the Proctor Scolar Award (Cincinnati Children's Research Foundation), the Pediatrician Scientist Award (Children's Health Research Center, NIH), the Clinical Scientist Award (National Kidney Foundation), and has been ranked as one of the Best Doctors in America, 2007-2011.

Education and Training

MD: Gorky Medical Institute, Gorky, Russia, 1985.

Residency: Miami Children's Hospital, Miami, Florida, 1997.

Fellowship: Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, 2000.

MS: Epidemiology and Biostatistics, University of Cincinnati, Cincinnati, Ohio, 2001.

Certifications: Educational Commission for Foreign Medical Graduates (ECFMG), 1995; Pediatrics, 1996; Pediatric Nephrology, 2001, 2008.

Publications

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Mitsnefes M, Flynn J, Cohn S, Samuels J, Blydt-Hansen T, Saland J, Kimball T, Furth S, Warady B; CKiD Study Group. Masked hypertension associates with left ventricular hypertrophy in children with CKD. J Am Soc Nephrol. 2010 Jan;21(1):137-44.

Wilson AC, Mitsnefes MM. Cardiovascular disease in CKD in children: update on risk factors, risk assessment, and management. Am J Kidney Dis. 2009 Aug;54(2):345-60. Review.

Flynn JT, Mitsnefes MM, Pierce C, Cole SR, Parekh RS, Furth SL and Warady BA. Blood pressure in children with chronic kidney disease: Preliminary findings from chronic kidney disease in children cohort study. Hypertension. 2008;52(4):631-7

Weaver DJ Jr, Kimball T, Witt SA, Glascock BJ, Khoury PR, Kartal J, Mitsnefes MM. Subclinical systolic dysfunction in pediatric patients with chronic kidney disease. J Pediatr. 2008 Oct;153(4):565-9.

Weaver DJ Jr., Kimball TR, Knilans T, Mays WK, Knecht T, Gerdes YT, Witt S, Glascock BJ, Kartal J, Khoury PR, and Mitsnefes MM. Decreased maximal aerobic capacity in pediatric chronic kidney disease. J Am Soc Nephrol. 2008, 19(3):624-30.

Mitsnefes MM, Kimball TR, Kimball TR, Witt SA, Glascock BJ, Khoury PR, and Daniels SR. Abnormal carotid artery structure and function in children with successful renal transplant. Circulation. 2004; 110:97-101.

Mitsnefes MM, Kimball TR, Kartal J, Witt SA, Glascock B, Khoury PR, Daniels SR. Cardiac and vascular adaptation in pediatric patients with chronic kidney disease: Role of calcium-phosphorus metabolism. J Am Soc Nephrol. 2005;16:2796-2803.

Mitsnefes MM, Kimball TR, Border WL, Witt SA, Glascock BJ, Khoury PR and Daniels SR. Impaired left ventricular diastolic function in children with chronic renal failure. Kidney Int. 2004;65(4):1461-1466.

Mitsnefes MM, Kimball TR, Witt SA, Glascock BJ, Khoury PR, and Daniels SR. Left ventricular mass and systolic performance in pediatric patients with chronic renal failure. Circulation. 2003;107:864-868

Mitsnefes MM, Daniels SR, Schwartz SM, Khoury P, Meyer RA, and Strife CF. Severe left ventricular hypertrophy in pediatric dialysis: prevalence and predictors. Pediatr Nephrol. 2000;14:898-902.

Grants

Adiponectin and Cardiovascular Disease in the CKiD Children. Principal Investigator. National Institutes of Health. 2007 - 2011. #R01 DK076957.

Modify Dietary Behavior in Adolescents with Elevated Blood Pressure. Co-investigator. National Institutes of Health. 2007 - 2012.

Prospective study of chronic kidney disease in children. Co-investigator, Co-chair of the Cardiovascular Committee. National Institutes of Health. 2003 - 2013. #U01 DK-03-012.

Cardiovascular disease in children with CKD. Principal Investigator. National Institutes of Health. 2011 - 2016. #K24 DK090070-01.

Edward J. Nehus, MD, MS

513-636-4531

edward.nehus@cchmc.org

Edward J. Nehus, MD, MS

Instructor, UC Department of Pediatrics

Phone: 513-636-4531

Email: edward.nehus@cchmc.org

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Specialties

Critical care nephrology; chronic kidney disease

Biography

Edward conducted and published a cross-sectional study which investigated the association of serum resistin with cardiovascular risk factors in children with chronic kidney disease. In addition, he recently published a study evaluating the outcomes steroid-avoidance protocols in pediatric kidney transplant recipients. He continues to be the primary investigator for ongoing studies that explore pharmacokinetic alterations in critically ill children receiving continuous renal replacement therapy.

Education and Training

MD: University of Toledo, Toledo, OH, 2002.

MS: University of Cincinnati, Cincinnati, OH, 2011.

Residency: Pediatrics, Nationwide Children’s Hospital, Columbus, OH.

Certification: Pediatrics, 2009.

Fellowship: Pediatric Nephrology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH.

Publications

View PubMed Publications

Nehus E, Goebel J, Abraham E. Outcomes of steroid-avoidance protocols in pediatric kidney transplant recipients. Am J Transplant. 2012 Sept 20. Epub ahead of print.

Nehus E, Furth S, Warady B, Mitsnefes M. Correlates of resistin in children with chronic kidney disease: the chronic kidney disease in children cohort. J Pediatr. 161(2): 276-80, 2012.

Nehus E, Goebel J, Mitsnefes M, Lorts A, Laskin B. Intensive hemodialysis for cardiomyopathy associated with end-stage renal disease. Pediatr Nephrol. 26: 1909-12, 2011.

Nehus E, Devarajan P. Acute kidney injury: AKI in kidney transplant recipients—here to stay. Nat Rev Nephrol. 8:198-199, 2012.

C. Frederic Strife, MD
Emeritus Professor

513-636-4531

fred.strife@cchmc.org

High Res

C. Frederic Strife, MD

Emeritus Professor

Director of the Dialysis Unit

Professor, UC Department of Pediatrics

Phone: 513-636-4531

Fax: 513-636-7407

Email: fred.strife@cchmc.org

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Specialties

Glomerulonephritis; renal tubular disorders; growth failure in chronic renal disease; dialysis

Education and Training

MD: College of Medicine and Dentistry of New Jersey, 1968.

Residency: Pediatrics, Children's Hospital Medical Center, Cincinnati, OH.

Fellowship: Nephrology, Children's Hospital Medical Center, Cincinnati, OH.

Certification: Pediatrics, 1973; Pediatric Nephrology, 1976.

Publications

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Calvo-Garcia MA, Campbell KM, O'Hara SM, Khoury P, Mitsnefes MM, Strife CF. Acquired renal cysts after pediatric liver transplantation: association with cyclosporine and renal dysfunction. Pediatr Transplant. 2008 Sep;12(6):666-71.

Vo NJ, Hammelman BD, Racadio JM, Strife CF, Johnson ND, Racadio JM. Anatomic distribution of renal artery stenosis in children: implications for imaging. Pediatr Radiol. 2006 Oct;36(10):1032-6.

Brunner HI, Bishnoi A, Barron AC, Houk LJ, Ware A, Farhey Y, Mongey AB, Strife CF, Graham TB, Passo MH. Disease outcomes and ovarian function of childhood-onset systemic lupus erythematosus. Lupus. 2006;15(4):198-206.

Mitsnefes MM, Subat-Dezulovic M, Khoury PR, Goebel J, Strife CF. Increasing incidence of post-kidney transplant anemia in children. Am J Transplant. 2005 Jul;5(7):1713-8.

Omoloja AA, Kumar K, Crawford AH, Strife CF. Epiphyseal stapling and recombinant human growth hormone for correction of genu valgum in children with chronic renal insufficiency. J Pediatr Orthop. 2003 Sep-Oct;23(5):639-42.

Lande MB, Gullion C, Hoss RJ, Gauthier B, Shah B, Leonard MB, Bonilla-Felix M, Nash M, Roy S, Strife CF, Arbus G. Long versus standard initial steroid therapy for children with the nephrotic syndrome. A report from the Southwest Pediatric Nephrology Study. Pediatr Nephrol. 2003;18:342-6.

Chand DH, Rhoades T, Poe SA, Kraus S, Strife CF. Incidence and severity of vesicoureteral reflux in children related to age, gender, race and diagnosis. J Urol. 2003;170:1548-1550.

Chand DH, Poe SA, Strife CF. Venous pressure monitoring does not accurately predict access failure in children. Pediatr Nephrol. 2002;17:765-770.

Mitsnefes MM, Daniels SR, Schwartz SM, Khoury P, Strife CF. Changes in left ventricular mass in children and adolescents during chronic dialysis. Pediatr Nephrol. 2001 Apr;16(4):318-23.

Mitsnefes MM, Daniels SR, Schwartz SM, Meyer RA, Khoury P, Strife CF. Severe left ventricular hypertrophy in pediatric dialysis: prevalence and predictors. Pediatr Nephrol. 2000 Sep;14(10-11):898-902.

Rene G. Van De Voorde III, MD
Medical Director, Dialysis Unit

513-636-4531

rene.vandevoorde@cchmc.org

High Res

Rene G. Van De Voorde, MD

Medical Director, Dialysis Unit

Assistant Professor, UC Department of Pediatrics

Phone: 513-636-4531

Fax: 513-636-7407

Email: rene.vandevoorde@cchmc.org

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Specialties

Dialysis; primarily infant dialysis; chronic kidney disease; acute kidney injury; hypertension

Education and Training

MD: Vanderbilt University.

Residency: Pediatrics, Cincinnati Children's Hospital.

Chief Resident: Pediatrics, Cincinnati Children's Hospital.

Fellowship: Pediatric Nephrology, Cincinnati Children's Hospital.

Certification: Pediatrics, 2003; Pediatric Nephrology, 2008.

Publications

View PubMed Publications

VanDeVoorde RG, Mitsnefes MM. Hypertension in chronic kidney disease in children. Advances in Chronic Kidney Disease. 2011.

Krawczeski CD, Vandevoorde RG, Kathman T, Bennett MR, Woo JG, Wang Y, Griffiths RE, Devarajan P. Serum cystatin C is an early predictive biomarker of acute kidney injury after pediatric cardiopulmonary bypass. Clin J Am Soc Nephrol. 2010 Sep;5(9):1552-7.

Alon US, VandeVoorde RG. Beneficial effect of cinacalcet in a child with familial hypocalciuric hypercalcemia. Pediatr Nephrol. 2010 Sep;25(9):1747-50.

Bredrup C, Matejas V, Barrow M, Bláhová K, Bockenhauer D, Fowler DJ, Gregson RM, Maruniak-Chudek I, Medeira A, Mendonça EL, Kagan M, Koenig J, Krastel H, Kroes HY, Saggar A, Sawyer T, Schittkowski M, Swietliński J, Thompson D, VanDeVoorde RG, Wittebol-Post D, Woodruff G, Zurowska A, Hennekam RC, Zenker M, Russell-Eggitt I. Ophthalmological aspects of Pierson syndrome. Am J Ophthalmol. 2008 Oct;146(4):602-611.

VanDe Voorde RG, Mitsnefes MM. Ambulatory blood pressure monitoring: a quest for truth. Pediatr Transplant. 2007 Feb;11(1):10-3.

Wuhl E, Kogan J, Zurowska A, Matejas V, VanDeVoorde RG, Aigner T, Wendler O, Lesniewska I, Bouvier R, Reis A, Weis J, Cochat P, Zenker M. Neuro-developmental deficits in Pierson (microcoria-congenital nephrosis) Syndrome. American Journal of Medical Genetics (A). 2007;143(4):311-9.

VanDeVoorde RG, Barletta G, Chand D, Dresner IG, Lane J, Leiser J, Lin JJ, Pan CG, Patel H, Valentini RP, Mitsnefes MM. Status of Blood Pressure Control in Children on Maintenance Hemodialysis: The Midwest Pediatric Nephrology Consortium (MWPNC) Study. Pediatric Nephrology. 2007;22(4):547-53.

VanDeVoorde R, Witte D, Kogan J, Goebel J. Pierson Syndrome: A Novel Cause of Congenital Nephrotic Syndrome. Pediatrics. 2006;118(2):E1-5.

Grants

Prospective, Multicenter Study to Evaluate the Safety of Vitamin D Receptor Activators as Determined by Hypercalcemia in Pediatric Patients ages 0 to 16 with Chronic Kidney Disease Stage 5 Receiving Peritoneal Dialysis within Current Clinical Practice. Site- Principal Investigator. Jun 2010 - present.

Randomized, Open-Label, Active-Controlled Study of the Safety, Efficacy, and Pharmacokinetics of Ferumoxytol Compared with Oral Iron for the Treatment of Iron Deficiency Anemia in Pediatric Subjects with Dialysis dependent Chronic Kidney Disease. Site Co-investigator. AMAG Pharmaceutical. Apr 2011 - present.

Randomized, Open-Label, Active-Controlled Study of the Safety, Efficacy, and Pharmacokinetics of Ferumoxytol Compared with Oral Iron for the Treatment of Iron Deficiency Anemia in Pediatric Subjects with Non-dialysis dependent Chronic Kidney Disease. Site-Principal Investigator. AMAG Pharmaceuticals. Apr 2011 - present.