Neuroblastoma Advanced Therapies Center

  • Meet the Team

    The Neuroblastoma Advanced Therapies Center is home to specialists with a wide variety of backgrounds and areas of focus. As a team, this diversity makes us better prepared to care for your child’s unique needs. Learn more about our faculty and staff.

  • Show All

    Director

    A photo of Brian Weiss.

    Brian D. Weiss, MD
    Associate Director for Safety and Compliance, Cancer and Blood Diseases Institute

    513-636-9863

    brian.weiss@cchmc.org

    Brian D. Weiss, MD

    Associate Director for Safety and Compliance, Cancer and Blood Diseases Institute

    Cincinnati Children's Principal Investigator, New Approaches to Neuroblastoma Therapy Consortium

    Medical Director, Neuroblastoma Program

    Associate Professor, UC Department of Pediatrics

    Phone: 513-636-9863

    Fax: 513-636-3549

    Email: brian.weiss@cchmc.org

    Show All

    Specialties

    Targeted agents for neurofibromatosis type 1-related malignancies; high-risk neuroblastoma and 131I-MIBG treatment of neuroblastoma; new approaches to targeting and killing neuroblastoma cells

    Education and Training

    MD: Northwestern University Medical School, Chicago, IL, 1993.

    Residency and Chief Residency: Pediatrics, University of California, San Francisco, CA, 1993-1997.

    Fellowship: Pediatric Hematology/Oncology, University of California, San Francisco, CA, 1997-2000.

    Certification: National Medical Board; Pediatrics;1996, 2002; Pediatric Hematology-Oncology, 2000, 2007

    Publications

    View PubMed Publications

    Grants

    Children's Oncology Group Chairs Grant. National Institutes of Health (Children's Oncology Group)
    U10 CA 098543 Mar 2011 - Feb 2012.

    Team Members

    A photo of Michael J. Gelfand, MD.

    Michael J. Gelfand, MD
    Chief, Section of Nuclear Medicine, Department of Radiology

    513-636-7650

    michael.gelfand@cchmc.org

    Michael J. Gelfand, MD

    Chief, Section of Nuclear Medicine, Department of Radiology

    Professor, UC Department of Radiology

    UC Department of Pediatrics

    Phone: 513-636-7650

    Fax: 513-636-8145

    Email: michael.gelfand@cchmc.org

    Show All

    Specialties

    Nuclear medicine

    Biography

    Michael J. Gelfand, MD, is chief of the Section of Nuclear Medicine at Cincinnati Children's Hospital Medical Center.

    He received his BA from the University of Michigan and his MD from Stanford University. After two years at the National Institutes of Health, he completed residencies in pediatrics at Cincinnati Children's and nuclear medicine at the University of Cincinnati Medical Center.

    Dr. Gelfand's research interests include I-123-MIBG imaging of neuroblastoma, new applications of hybrid imaging (PET/CT, SPECT/CT, PET/MRI) in pediatrics, and radiation dose reduction in nuclear medicine and hybrid imaging.

    Dr. Gelfand has served as president of the Society of Nuclear Medicine, and served on the Board of Directors of that organization for 10 years.

    Dr. Gelfand co-edited the textbooks Effective Use of Computers in Nuclear Medicine and Pediatric Nuclear Imaging. His publications include 126 journal articles and 31 book chapters. He has been an invited lecturer or visiting professor in France, Germany, the Netherlands, Italy, Argentina, Brazil, Japan and Australia.

    Education and Training

    BA: University of Michigan, Ann Arbor, MI, 1966. 

    MD: Stanford University, Stanford, CA, 1971. 

    Residency: Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 1973-1975, 1977; Nuclear Medicine, University of Cincinnati, Cincinnati, OH, 1975-1977. 

    Certification: Pediatrics, 1978; Nuclear Medicine, 1978.

    Publications

    View PubMed Publications

    Trent R. Hummel, MD

    Assistant Professor, UC Department of Pediatrics

    Phone: 513-803-1126

    Fax: 513-636-3549

    Email: trent.hummel@cchmc.org

    Show All

    Specialties

    Neuro-oncology; CNS tumors in neurofibromatosis type 1 and 2 research interests: developing novel therapeutics in central nervous system tumors including those with very poor prognosis such as high grade gliomas and diffuse intrinsic pontine gliomas.

    Biography

    Trent R. Hummel, MD, completed his graduate medical training at the University of Cincinnati College of Medicine, residency training in pediatrics at Children's Hospital Medical Center of Akron and pediatric hematology/oncology training at Cincinnati Children's Hospital Medical Center. His current appointment is with the University of Cincinnati and Children's Hospital Medical Center in the capacity of assistant professor of pediatrics.

    Dr. Hummel's clinical and academic interests pertain to children and families affected by central nervous system tumors. He is a member of the Central Nervous System (Brain Tumor) Committee in the Children's Oncology Group (COG) as well as CCHMC's co-principal investigator for the Pediatric Brain Tumor Consortium (PBTC). Dr. Hummel focuses on developing novel therapeutics to treat children with all central nervous system tumors including those patients with neurofibromatosis type 1 and 2 related CNS tumors and very poor prognosis tumors such as high-grade gliomas and diffuse intrinsic pontine gliomas.

    Education and Training

    BS: Eastern Mennonite University, 1997. 

    MD: University of Cincinnati College of Medicine, 2001.

    Residency: Children’s Hospital Medical Center of Akron, Akron, Ohio, 2004.

    Fellowship: Pediatric Hematology / Oncology, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, 2007; Research Fellow, Division of Experimental Hematology, Cincinnati Children’s Hospital Medical Center, 2008.

    Certification: American Board of Pediatrics, 2004. Pediatrics, 2004. Pediatric Hematology / Oncology, 2011.

    Publications

    View PubMed Publications

    Sonata Jodele

    Associate Professor, UC Department of Pediatrics

    Phone: 513-636-1565

    Fax: 513-636-3549

    Email: sonata.jodele@cchmc.org

    Show All

    Specialties

    Bone marrow transplantation

    Education and Training

    MD: Vilnius University School of Medicine, 1988-1994.

    Residency: Pediatrics, Downstate HSC at Brooklyn, Brooklyn, NY, 1998-2001.

    Fellowship: Pediatric Hematology Oncology, Children's Hospital Los Angeles and Saban Research Institute, Keck School of Medicine University of Southern California, Los Angeles, CA, 2001-2004.

    Certifications: Pediatrics, 2001; Pediatric Hematology / Oncology, 2004.

    Licenses: California, 2001-present; Ohio, 2004-present.

    Publications

    View PubMed Publications
    A photo of Brian Weiss.

    Brian D. Weiss, MD
    Associate Director for Safety and Compliance, Cancer and Blood Diseases Institute

    513-636-9863

    brian.weiss@cchmc.org

    Brian D. Weiss, MD

    Associate Director for Safety and Compliance, Cancer and Blood Diseases Institute

    Cincinnati Children's Principal Investigator, New Approaches to Neuroblastoma Therapy Consortium

    Medical Director, Neuroblastoma Program

    Associate Professor, UC Department of Pediatrics

    Phone: 513-636-9863

    Fax: 513-636-3549

    Email: brian.weiss@cchmc.org

    Show All

    Specialties

    Targeted agents for neurofibromatosis type 1-related malignancies; high-risk neuroblastoma and 131I-MIBG treatment of neuroblastoma; new approaches to targeting and killing neuroblastoma cells

    Education and Training

    MD: Northwestern University Medical School, Chicago, IL, 1993.

    Residency and Chief Residency: Pediatrics, University of California, San Francisco, CA, 1993-1997.

    Fellowship: Pediatric Hematology/Oncology, University of California, San Francisco, CA, 1997-2000.

    Certification: National Medical Board; Pediatrics;1996, 2002; Pediatric Hematology-Oncology, 2000, 2007

    Publications

    View PubMed Publications

    Grants

    Children's Oncology Group Chairs Grant. National Institutes of Health (Children's Oncology Group)
    U10 CA 098543 Mar 2011 - Feb 2012.

    Researchers

    Lionel M.L. Chow, MD, PhD

    Assistant Professor, UC Department of Pediatrics

    Phone: 513-803-1369

    Fax: 513-803-1083

    Email: lionel.chow@cchmc.org

    Show All

    Specialties

    Clinical Interests

    Pediatric neuro-oncology

    Research Interests

    Mouse models for glioma; molecular profiling of tumor mutations; biomarkers of tumor progression; novel therapeutic agents for glioma

    Visit the Chow Lab

    Biography

    Lionel Chow, MD, PhD, received his medical and graduate degrees from McGill University in Montreal, Canada, where his research focused on the regulation of T-lymphocyte signaling by the intracellular tyrosine protein kinases Lck and Csk.

    Following his clinical training in pediatrics and pediatric hematology / oncology at the Hospital for Sick Children in Toronto, Canada, he moved to St. Jude Children’s Research Hospital in Memphis, Tenn., to pursue his research interests.

    Chow's research interests have been centered on glioblastoma multiforme, a particularly devastating form of cancer in adults and children. His work has resulted in the development of a number of novel and robust laboratory models for this disease. Using these models and interfacing with clinical trials in the Neuro-Oncology Program as well as those from national consortia such as the Children's Oncology Group (COG) and the Pediatric Brain Tumor Consortium (PBTC), Chow’s laboratory will continue research in this area with the goals of better understanding the origins of this form of cancer and improving patient outcomes.

    Education and Training

    PhD: McGill University, Montreal, Quebec, Canada, 1996.

    MDCM: McGill University, Montreal, Quebec, Canada, 1997.

    Residency: The Hospital for Sick Children, University of Toronto, Toronto, Canada, 1997-2000.

    Clinical Fellowship: The Hospital for Sick Children, University of Toronto, Toronto, Canada, 2000-2003.

    Postdoctoral Fellowship: St. Jude Children’s Research Hospital, Memphis, TN, 2003-2009.

    Clinical Fellowship: St. Jude Children’s Research Hospital, Memphis TN, 2008-2009.

    Certification: Pediatrics, 2000.

    Publications

    View PubMed Publications

    Grants

    2013 – 2014 Sophie’s Angel Run Foundation
    “Preclinical Testing of Notch and mTor Inhibition in a Mouse Model for High-Grade Glioma” 

    2011 – 2014 St. Baldrick’s Foundation Scholars Award
    "Molecular targeting of pediatric high-grade glioma"

    2011 – 2015 Sontag Foundation Distinguished Scientist Award
    "Molecular targeting of high-grade astrocytoma"

    Biplab Dasgupta, PhD, MS

    Assistant Professor, UC Department of Pediatrics

    Phone: 513-803-1370

    Fax: 513-803-1083

    Email: biplab.dasgupta@cchmc.org

    Show All

    Specialties

    Biography

    Biplab Dasgupta, PhD, MS, completed his doctorate in molecular biology and immunology at the Indian Institute of Chemical Biology, Calcutta, and a postdoctoral fellowship at Washington University School of Medicine, Saint Louis. Dr. Dasgupta came to Cincinnati Children's Hospital Medical Center in August 2009 as an assistant professor of pediatrics. He is interested in understanding how neural cell / stem cell metabolic and energy status is linked to cell cycle, lineage commitment, differentiation and tumorigenesis. His other interests include genetic, developmental, post-translational, tissue- and stimuli–specific regulation of the subunits that constitute the AMP kinase complex.

    Education and Training

    PhD: Indian Institute of Chemical Biology, Calcutta, 2003

    Postdoctoral Fellowship:
    Washington University School of Medicine, Saint Louis

    Publications

    View PubMed Publications

    Grants

    Regulation of Forebrain Neurogenesis by the Energy Sensor AMP Kinase. Principal Investigator. National Institute of Neurological Disorders and Stroke (NINDS). July 2012 – June 2017.

    Rachid Drissi, PhD

    Assistant Professor, UC Department of Pediatrics

    Phone: 513-636-4266

    Fax: 513-636-3549

    Email: rachid.drissi@cchmc.org

    Show All

    Education and Training

    BS: University of Rouen, France, 1983.

    MS: University of Rouen, France, 1984.

    MS: University of Paris VI, France, 1988.

    PhD: University of Paris VI, France, 1994.

    Publications

    View PubMed Publications
    A photo of Dr. Perentesis.

    John P. Perentesis, MD, FAAP
    Director, Division of Oncology and Cancer Programs

    513-636-8241

    john.perentesis@cchmc.org

    A photo of Dr. Perentesis.

    John P. Perentesis, MD, FAAP

    Director, Division of Oncology and Cancer Programs

    Deb Kleisinger Endowed Chair of Novel Cancer Treatments

    Executive Co-Director, Cancer and Blood Diseases Institute

    Director, Leukemia / Lymphoma Program

    Cincinnati Children's Principal Investigator, Children’s Oncology Group (COG)

    Cincinnati Children's Principal Investigator, National Cancer Institute Pediatric Phase 1 Consortium

    Professor, UC Department of Pediatrics

    Phone: 513-636-8241

    Email: john.perentesis@cchmc.org

    Show All

    Specialties

    Clinical Interests

    Acute myeloid leukemia; neuroblastoma; PNET / Ewing's sarcoma and osteosarcoma; new anticancer drug development; Phase I clinical trials

    Research Interests

    Molecular etiology and pharmacogenetics of pediatric cancers; Down syndrome-associated leukemia; new anticancer drug development

    Biography

    John P. Perentesis, MD, is a nationally recognized expert in the development of new drugs and molecular therapies for pediatric and young adult cancers and leukemia. His laboratory has developed novel anticancer drugs, and discovered genes important in the growth of normal and malignant cells. His laboratory is also developing the use of tumor and patients genetics research for personalizing therapies. In clinical research, he serves in leadership roles for the National Cancer Institute’s Investigational Drug Steering Committee and the NCI Pediatric Phase I Consortium.

    In 2010, Dr. Perentesis was elected by pediatric oncologists from across the country to the national Executive Committee for the NCI-funded Children’s Oncology Group (COG). The COG is the world's largest, cooperative children's cancer research entity. He also is in leadership efforts in the COG for new therapies for leukemia, and adolescent and young adult cancers.

    Education and Training

    MD: University of Michigan, Ann Arbor, MI, 1980.

    Residency: University of Minnesota Medical School, Minneapolis, MN, 1983.

    Fellowship: University of Minnesota Medical School, Minneapolis, MN, 1986.

    Postdoctoral: University of Minnesota Medical School, Minneapolis, MN, 1986.

    Certification: Pediatrics, 1989; Hematology/Oncology, 1990.

    Publications

    View PubMed Publications

    Grants

    The Children's Oncology Group Chair Grant. Site Principal Investigator. National Institutes of Health. Mar 2008 - Mar 2013. #U10 CA 098543.

    Children's Oncology Group Phase I. Site Principal Investigator. National Institutes of Health. Aug 2002 - Jul 2012. #U01 CA 097452.

    Children's Oncology Group New Publication Committee. National Institutes of Health. Sep 2006 - Jul 2012. #U01 CA 97542 .

    Cincinnati Children's Hyundai Scholar in Childhood Cancer Drug Development. Hyundai Hope on Wheels. Oct 2010 - Oct 2011.


    A photo of Nancy Ratner.

    Nancy Ratner, PhD
    Beatrice C. Lampkin Chair, Cancer Biology

    513-636-9469

    nancy.ratner@cchmc.org

    Nancy Ratner, PhD

    Beatrice C. Lampkin Chair, Cancer Biology

    Professor, UC Department of Pediatrics

    Phone: 513-636-9469

    Fax: 513-636-3549

    Email: nancy.ratner@cchmc.org

    Show All

    Specialties

    Clinical Interests

    Development of the nervous system; peripheral nerve tumor formation

    Research Interests

    Genetic mutations in tumor suppressor genes

    Visit the Ratner Lab.

    Biography

    Dr. Nancy Ratner PhD,  is interested in understanding mechanisms of peripheral nerve tumor (neurofibroma) formation in Neurofibromatosis type 1 (NF1), a common inherited disorder in which children are predisposed to cancer of the nervous system, to learning problems, bone disorders, and other cancers. She identified EGFR as a potential therapeutic target in NF1 peripheral nerve tumorigenesis, and has developed cell culture and mouse models of NF1 nerve tumorigenesis. Her laboratory has also used analysis of gene expression to identify critical genes in neurofibroma and their malignant derivatives, MPNST. 

    Dr. Ratner received her bachelor's from Brown University, her doctorate from Indiana University, and was a postdoctoral fellow at Washington University in St. Louis. She was a member of the faculty at the University of Cincinnati from 1987 -  2004. Dr. Ratner is currently a professor in the Department of Pediatrics, Cincinnati Children’s Hospital, University of Cincinnati, and the program leader for Cancer Biology and Neural Tumors Program in the Cancer and Blood Disorders Institute where she holds the Beatrice C. Lampkin Endowed Chair in Cancer Biology and serves as PI of the NINDS P50 “Cincinnati Center in NF Research”. 

    Dr. Ratner is an active member of the International Consortium on the Molecular Biology of NF1, NF2, and schwannomatosis and was a member of the advisory board for the National Neurofibromatosis Foundation (now Children’s Tumor Foundation) from 1989 – 2007. She chaired the Department of Defense Neurofibromatosis Research Program Integration Panel in 2008, and currently serves as a member of the James McDonnell Brain Tumor Research Advisory Board. She received the von Recklinghausen Award from the Children’s Tumor Foundation in 2010.

    Education and Training

    PhD: Indiana University, 1982.

    BA: Brown University, 1975.

    Fellowship: Washington University St. Louis, 1982-1987.

    Publications

    View PubMed Publications

    Grants

    NIH-R01 NS 28840-20, "Mitogenic Activities in Neurofibromatosis", 9/2011 - 9/2016 (Ratner, PI)

    NIH-R01 CA118032-04, "Schwann cells in Neurofibromatosis type 2", 7/2007 - 6/2012 (Ratner, PI)

    NIH-P50-NS057531-03, "Cincinnati Center for Neurofibromatosis Research", 7/2008 - 6/2013 (Ratner, PI)

    Children's Tumor Foundation, "Preclinical Testing of Neurofibroma and MPNST", 7/2009 - 6/2011 (Cripe, PI, Ratner, Co-PI)

    U.S. Army NF Program, NF080052, "Therapeutic Targets for Peripheral Nerve Tumors: NF1, NF2, and Schwannomatosis", 3/2009 - 9/2011 (Ratner, PI) 

    U.S. Army NF Program, DOD W81XWH-10-1-0116,  "Modeling the Brain in NF1", 4/2010 - 3/2013 (Ratner, PI)

    Jianqiang Wu, MD, MS

    Assistant Professor, UC Department of Pediatrics

    Phone: 513-636-0955

    Fax: 513-803-0783

    Email: jianqiang.wu@cchmc.org

    Show All

    Specialties

    Preclinical therapeutic trial on neurofibroma; cancer stem cell(s) in neurofibroma

    Education and Training

    MD: Soochow University College of Medicine, SooChow, P.R. China, 1991.

    MS: Soochow University College of Medicine, SooChow, P.R. China, 1996.

    Publications

    View PubMed Publications