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Learn more about the team members in the Neurogastroenterology and Motility Disorders Program.
Ajay Kaul, MBBS, MD
Associate Professor, UC Department of Pediatrics
Kaul A, Garza JM, Connor FL, Cocjin JT, Flores AF, Hyman PE, Di Lorenzo C. Colonic Hyperactivity Results in Frequent Fecal Soiling in a Subset of Children After Surgery for Hirschsprung Disease. J Pediatr Gastroenterol Nutr. 2011 Jan 12.
Blanchard C, Stucke EM, Rodriguez-Jimenez B, Burwinkel K, Collins MH, Ahrens A, Alexander ES, Butz BK, Jameson SC, Kaul A, Franciosi JP, Kushner JP, Putnam PE, Abonia JP, Rothenberg ME. A striking local esophageal cytokine expression profile in eosinophilic esophagitis. J Allergy Clin Immunol. 2011 Jan;127(1):208-17, 217.e1-7.
Garza JM, Kaul A. Gastroesophageal reflux, eosinophilic esophagitis, and foreign body. Pediatr Clin North Am. 2010 Dec;57(6):1331-45. Review.
Zhu X, Wang M, Mavi P, Rayapudi M, Pandey AK, Kaul A, Putnam PE, Rothenberg ME, Mishra A. Interleukin-15 expression is increased in human eosinophilic esophagitis and mediates pathogenesis in mice. Gastroenterology. 2010 Jul;139(1):182-93.e7.
Caldwell JM, Blanchard C, Collins MH, Putnam PE, Kaul A, Aceves SS, Bouska CA, Rothenberg ME. Glucocorticoid-regulated genes in eosinophilic esophagitis: a role for FKBP51. J Allergy Clin Immunol. 2010 Apr;125(4):879-888.e8.
Blanchard C, Stucke EM, Burwinkel K, Caldwell JM, Collins MH, Ahrens A, Buckmeier BK, Jameson SC, Greenberg A, Kaul A, Franciosi JP, Kushner JP, Martin LJ, Putnam PE, Abonia JP, Wells SI, Rothenberg ME. Coordinate interaction between IL-13 and epithelial differentiation cluster genes in eosinophilic esophagitis. J Immunol. 2010 Apr 1;184(7):4033-41.
Jafri M, Alonso M, Kaul A, Dierig J, Racadio J, Inge T, Brown R, Ryckman F, Tiao G. Intraoperative manometry during laparoscopic Heller myotomy improves outcome in pediatric achalasia. J Pediatr Surg. 2008 Jan;43(1):66-70; discussion 70.
Pentiuk SP, Miller CK, Kaul A. Eosinophilic esophagitis in infants and toddlers. Dysphagia. 2007 Jan;22(1):44-8.
Boesch RP, Daines C, Willging JP, Kaul A, Cohen AP, Wood RE, Amin RS. Advances in the diagnosis and management of chronic pulmonary aspiration in children. Eur Respir J. 2006 Oct;28(4):847-61. Review.
Bates MD, Dunagan DT, Welch LC, Kaul A, Harvey RP. The Hlx homeobox transcription factor is required early in enteric nervous system development. BMC Dev Biol. 2006 Jul 19;6:33.
Maria H. Alonso-Peclet, MD Surgical Director, Kidney Transplant Program
Surgical Director, Kidney Transplant Program
Co-Surgical Director, Intestinal Transplant Surgery
Associate Professor, UC Department of Surgery
MD: University of Pennsylvania School of Medicine, Philadelphia, PA, 1982.
Residency: Surgery, Eastern Virginia Graduate School of Medicine, Norfolk, VA.
Fellowship: Trauma / Critical Care, Maryland Institute for Emergency Medical Services Systems, Baltimore, MD; Trauma / Burn, Children's National Medical Center, Washington, D.C.; Pediatric Surgery, Children's Mercy Hospital, Kansas City, MO; Transplantation, University of Cincinnati College of Medicine, Cincinnati, OH.
Certification: Surgery, 1999; Pediatric Surgery, 2001; Surgical Critical Care, 2001.
Leslie Fitzharris, CNP Pediatric Nurse Practitioner, Neurogastroenterology and Motility Disorder Program
Pediatric Nurse Practitioner, Neurogastroenterology and Motility Disorder Program
Pediatric Gastroenterology; motility disorders; DDBP
BS: Biology, University of Toledo, Toledo, OH, 1996.
RN and NP: Frances Payne Bolton School of Nursing, Case Western Reserve University Cleveland, Ohio, 1999.
Jason S. Frischer, MD Interim Director, Peña Colorectal Center
Interim Director, Peña Colorectal Center
Director, Extracorporeal Membrane Oxygenation (ECMO) Program
Division of Pediatric General and Thoracic Surgery
Assistant Professor, UC Department of Surgery
Chernoguz A, Crawford, K, Vandersall A, Willson T, Denson LA, Frischer JS. Pre-treatment with Anti-VEGF therapy may exacerbate inflammation in experimental acute colitis. J Pediatr Surg. 2012 Feb;47(2):347-54.
Le LD, Keswani SG, Biesiada J, Lim FY, Kingma PS, Haberman BE, Frischer J, Habli M, Crombleholme TM. The congenital diaphragmatic hernia composite prognostic index correlates with survival in left-sided congenital diaphragmatic hernia. J Pediatr Surg. 2012 Jan;47(1):57-62.
Lawal TA, Falcone RA, von Allmen D, Denson LA, Levitt MA, Warner BW, Frischer JS. The utility of routine pouchogram before ileostomy reversal in children and adolescents following ileal pouch anal anastomosis. J Pediatr Surg. 2011 Jun;46(6):1222-5.
Chernoguz A, Crawford KM, Donovan EC, Vandersall AE, Berglund C, Cripe TP, Frischer JS. EGFR Inhibition Fails to Suppress Vascular Proliferation and Tumor Growth in a Ewing’s Sarcoma Model. J Surg Res. 2012 Mar;173(1):1-9.
Lawal TA, Frischer JS, Falcone RA, Chatoorgoon K, Denson LA, Levitt MA. The transanal approach with laparoscopy or laparotomy for the treatment of rectal strictures in Crohn’s disease. J Laparoendosc Adv Surg Tech A. 2010 Nov;20(9):791-5.
Bischoff A, Gupta A, D’Mello S, Mezoff A, Podberesky D, Barnett S, Keswani S, Frischer JS. Crohn’s disease limited to the appendix: a case report in a pediatric patient. Pediatr Surg Int. 2010 Nov;26(11):1125-8.
Vuletin JF, Lim FY, Cnota J, Kline-Fath B, Salisbury S, Haberman B, Kingma P, Frischer JS, Crombleholme T. Prenatal pulmonary hypertension index: novel prenatal predictor of severe postnatal pulmonary artery hypertension in antenatally diagnosed congenital diaphragmatic hernia. J Pediatr Surg. 2010 Apr;45(4):703-8.
Frischer JS, Lee A, Serur A, Huang J, Bae JO, Kornfield ZN, Eljuga L, Shawber CJ, Feirt N, Mansukhani M, Stempak D, Baruchel S, Bender JG, Kandel JJ, Yamashiro DJ. Inhibition of cyclooxygenase-2 disrupts tumor vascular mural cell recruitment and survival signaling. Cancer Res. 2006 Apr;66(8):4378-84.
Frischer JS, Huang J, Serur A, Kadenhe-Chiweshe A, McCrudden KW, O’Toole K, Holash J, Yancopoulos GD, Yamashiro DJ, Kandel JJ. Effects of potent VEGF blockade on experimental Wilms tumor and its persisting vasculature. Int J Onc. 2004 Sep;25(3):549-53.
Huang J, Frischer JS, Serur A, Kadenhe A, Yokoi A, McCrudden KW, New T, O’Toole K, Zabski S, Rudge JS, Holash J, Yancopoulos GD, Yamashiro DJ, Kandel JJ. Regression of established tumors and metastases by potent vascular endothelial growth factor blockade. Proc Natl Acad Sci USA. 2003 June 24;100(13):7785-90.
Belinda Hsi Dickie, MD, PhD Pediatric Surgeon, Peña Colorectal Center
Pediatric Surgeon, Peña Colorectal Center
Assistant Professor, UC Department of Pediatrics
Phone: 513-636 3240
Colorectal surgery; vascular malformations; minimally invasive surgery; general pediatric surgery
Belinda Hsi Dickie, MD, PhD, is an assistant professor with the Division of Pediatric General and Thoracic Surgery at Cincinnati Children's Hospital Medical Center. She obtained her medical degree at the University of Toronto, Ontario Canada and subsequently did her general surgery residency, and completed her PhD, at the University of Alberta, Alberta, Canada. Dr. Dickie continued her training at the University of Alberta, with a fellowship in advanced minimally invasive surgery focusing on upper and lower intestinal surgery. She then relocated to the United States where she continued her training and completed fellowships in pediatric vascular malformations and pediatric colorectal surgery at Cincinnati Children’s Hospital Medical Center. Her training in pediatric surgery was completed at the University of Florida. She was recruited back to Cincinnati Children's in 2011 to join the Department of Surgical Services, Colorectal Center, and Hemangioma and Vascular Malformations Center. She is the current surgical director of the HVMC Center.
Dr. Dickie has a special interest in pediatric colorectal surgery, in particular reconstructive surgery of anorectal malformations, Hirschsprung's disease, motility disorders and inflammatory bowel disease. She is also interested in integrating minimally invasive surgical techniques to the management of these diseases. She is interested in studying the long-term outcomes of these conditions and how to improve the overall health of these children. She has been a guest professor and operated internationally. Her second area of interest is in the medical and surgical treatment of vascular anomalies. She has a lab that is actively investigating the genetics and molecular pathways involved in lymphangiogenesis and the abnormal development seen in lymphatic related disease.
MD: University of Toronto, Toronto,Ontario, Canada 1998.Residency: General Surgery, University of Alberta, Edmonton, Alberta, Canada.Fellowship: Advanced Minimally Invasive Surgery, University of Alberta, Edmonton, Alberta, Canada; Vascular anomalies, Cincinnati Children's, Cincinnati, OH; Pediatric Colorectal Surgery, Cincinnati Children's, Cincinnati, OH; Pediatric Surgery, University of Florida Gainesville, Florida, Certification: General Surgery, 2006; Pediatric Surgery, 2011.
Dickie BH, Webb KM, Eradi B, Levitt MA. The problematic Soave cuff in Hirschsprung disease: Manifestations and treatment. J Pediatr Surg. 2014 Jan;49(1):77-81.
Knod JL, Garrison AP, Frischer JS, Dickie B. Foregut duplication cyst associated with esophageal atresia and tracheoesophageal fistula: a case report and literature review. J Pediatr Surg. 2013 May;48(5):E5-7.
de Blaauw I, Midrio P, Breech L, Bischoff A, Dickie B, Versteegh HP, Peña A, Levitt MA. Treatment of adults with unrecognized or inadequately repaired anorectal malformations: 17 cases of rectovestibular and rectoperineal fistulas. J Pediatr Adolesc Gynecol. 2013 Jun;26(3):156-60.
Levitt MA, Dickie B, Peña A. The Hirschsprungs patient who is soiling after what was considered a "successful" pull-through. Semin Pediatr Surg. 2012 Nov;21(4):344-53.
Murrell Z, Dickie B, Dasgupta R. Lung nodules in pediatric oncology patients: a prediction rule for when to biopsy. J Pediatr Surg. 2011 May;46(5):833-7.
Cuenca AG, Reddy SV, Dickie B, Kays DW, Islam S. The usefulness of the upper gastrointestinal series in the pediatric patient before anti-reflux procedure or gastrostomy tube placement. J Surg Res. 2011 Oct;170(2):247-52.
Levitt MA, Dickie B, Peña A. Evaluation and treatment of the patient with Hirschsprung disease who is not doing well after a pull-through procedure. Semin Pediatr Surg. 2010 May;19(2):146-53.
Dickie B, Dasgupta R, Nair R, Alonso MH, Ryckman FC, Tiao GM, Adams DM, Azizkhan RG. Spectrum of hepatic hemangiomas: management and outcome. J Pediatr Surg. 2009 Jan;44(1):125-33.
Kneteman NM, Weiner AJ, O'Connell J, Collett M, Gao T, Aukerman L, Kovelsky R, Ni ZJ, Zhu Q, Hashash A, Kline J, Hsi B, Schiller D, Douglas D, Tyrrell DL, Mercer DF. Anti-HCV therapies in chimeric scid-Alb/uPA mice parallel outcomes in human clinical application. Hepatology. 2006 Jun;43(6):1346-53. Hao C, Song JH, Hsi B, Lewis J, Song DK, Petruk KC, Tyrrell DL, Kneteman NM. TRAIL inhibits tumor growth but is nontoxic to human hepatocytes in chimeric mice. Cancer Res. 2004 Dec 1;64(23):8502-6.
Steven J. Kraus, MD Chief, Radiography and Fluoroscopy
Chief, Radiography and Fluoroscopy
Radiologist, Department of Radiology
Associate Professor, UC Department of Radiology
Genitourinary; gastrointestinal imaging in children
Steven Kraus, MD, grew up in New England and received his BS from the University of Hartford, and his MS degree from the University of Connecticut. Dr. Kraus received his MD from the Medical College of Virginia, Virginia Commonwealth University, and completed a radiology residency at the University of Minnesota Medical Center. He completed a two-year fellowship in Pediatric Radiology at Children's Hospital and Harvard Medical School in Boston, MA.
Dr. Kraus is currently the Division Chief of Radiology and Fluoroscopy at Cincinnati Children's. His special areas of clinical interest are genitourinary and gastrointestinal imaging in children.
Dr. Kraus' research interests include imaging of anorectal malformations, radiologic workup in children with urinary tract infections and outcomes studies in GI and GU radiology. He has particular interest in medical education.
BS: University of Hartford, West Hartford, CT, 1979-1983.
MS: University of Connecticut, Storrs, CT, 1983-1987.
MD: Medical College of Virginia, Virginia Commonwealth University, Richmond, VA.
Internship: Transitional Hennepin County Medical Center, Minneapolis, MN, 1992-1993.
Residency: Diagnostic Radiology, University of Minnesota Health Center, Minneapolis, MN, 1993-1997. Fellowship: Chief Fellow, Pediatric Radiology, Boston Children's Hospital and Harvard Medical School, Boston, MA, 1997-1999.Certification: Diagnostic Radiology, American Board of Radiology, 1997; CAQ Pediatric Radiology, American Board of Radiology, 2000.
Kraus SJ, Levitt MA, Peña A. Augmented-Pressure Distal Colostogram: The Anatomic Evaluation of Anorectal Malformations in Male and Selected Female Patients with Imperforate Anus Prior to Definitive Surgical Repair; a Pictorial Essay. Pediatric Radiology. Accepted with Revisions.
Garrett KM, Levitt MA, Peña A, Kraus SJ. Contrast Enema Findings in Patients Presenting With Poor Functional Outcome after Primary Repair for Hirschsprung Disease. Pediatr Radiol. 2012 Sept;42(9):1099-1106.
Calvo-Garcia MA, Kline-Fath BM, Levitt MA, Lim FY, Linam LE, Patel MN, Kraus SJ, Crombleholme TM. Fetal MRI clues to diagnose cloacal malformation. Pediatric Radiol, 2011;41(9):1117-1128.
Kraus SJ. Imaging of Vesicoureteral Reflux. Indian Journal of Pediatrics. 2004.
Chand DH, Rhoades T, Poe SA, Kraus SJ Strife CF. Incidence and Severity of Vesicoureteral Reflux in Children Related to Age, Gender, Race and Diagnosis. The Journal of Urology. 2003;170:1548-1550.
Guillerman P, Brody AS, Kraus SJ. Evidence-Based Guidelines for Pediatric Imaging: The example of the Child with Possible Appendicitis. Pediatric Annals. 2002;31(10):629-40.
Kraus SJ. GU Imaging in Children. Pediatric Clinics of North America. 2001; 48:1381-1424.
Garcia-Pena BM, Mandl KD, Kraus SJ, Fischer AC, Lund DP, Taylor GA. Ultrasonography and Limited Computed Tomography in the Diagnosis and Management of Appendicitis in Children. Journal of the American Medical Association (JAMA). 1999 Sep 15; 282(11):1041-1046.
Kraus SJ, Lebowitz RL, Royal SA. Renal calculi in children: imaging features that lead to diagnoses: a pictorial essay. Pediatric Radiology. 1999; 29:624-630.
Kazziha SY, Kraus SJ, Loesser KE, Hess ML. Photosensitizer studies with rose bengal-derived reactive oxygen intermediates on isolated papillary rat heart muscle. FASEB. 1991; 5:A1282 (Abstract).
Greg M. Tiao, MD Richard and Geralyn Azizkhan Chair in Pediatric Surgery
Richard and Geralyn Azizkhan Chair in Pediatric Surgery
Surgical Director, Liver Transplantation
Associate Director, Pediatric Surgery Fellowship
UC Department of Pediatrics
As a pediatric surgeon and a transplant surgeon, Dr. Tiao is involved in the care of children afflicted with biliary atresia from the time of presentation and diagnosis to the initial Kasai portoenterostomy to the liver transplant, when necessary. He sees the many challenges children and their families experience when diagnosed with this life threatening disease process. From that perspective, defining the basis of this disease process such that therapeutic strategies can be developed eliminating these complex interventions is his career goal. His short term goal is to develop an independent research laboratory investigating the pathogenesis of virus induced biliary atresia specifically seeking to determine the mechanistic basis of this disease so that new treatment strategies can be developed to salvage the native liver.
Dr. Tiao's overarching hypothesis is that biliary atresia results from the infection of cholangiocytes by a virus triggering immune-mediated biliary obstruction. His focus is to determine the mechanisms used by RRV to infect cholangiocytes, how RRV undergoes replication within the cholangiocyte, and how infected cholangiocytes modify the microenvironment, activating the immune system resulting in biliary obstruction. Determination of the mechanistic basis of these inter-related events is essential to understanding the pathogenesis of virus induced BA. By focusing on the basis for the viral insult in the initiation of biliary atresia, he has defined an area of independence from Dr Jorge Bezerra, his primary research mentor.
BS: Northwestern University, Evanston, IL, 1986.
MD: University of Illinois, Chicago, IL, 1990.
Residency: Loyola University, Maywood, IL, 1991-1992; Senior Resident, Department of Surgery, University of Cincinnati, Cincinnati, OH, 1995-1997;Chief Resident, Department of Surgery, University of Cincinnati, Cincinnati, OH, 1997-1998.
Fellowships: Research Fellow, University of Cincinnati, Cincinnati, OH, 1992-1995; Transplant Surgery Fellow, University of Cincinnati, Cincinnati, OH, 2000-2002;Pediatric Surgery Fellow, Los Angeles Children's Hospital, Los Angeles, CA, 1998-2000.
Certification: Pediatric Surgeon, 2000; Transplant Surgeon, 2002.
Coots A, Donnelly B, Mohanty S, Tiao G. Rotavirus Infection of Human Cholangiocytes Parallels the Murine Model of Biliary Atresia. Journal of Surgical Research. Epub ahead of print. 2012.
Meyers RL, Tiao GM, Dunn SP, Langham Jr, MR. Liver transplantation in the management of unresectable hepatoblastoma in children. Frontiers in Bioscience. 2012 Jan;E4:1293-1302.
Shin CR, Nathan J, Alonso M, Yazigi N, Kocoshis S, Tiao G, Davies SM. Incidence of acute and chronic graft-versus-host disease and donor T-cell chimerism after small bowel or combined organ transplantation. J Pediatr Surg. 2011;46:1732-1738.
Fernandez KS, Baum R, Fung B, Yeager N, Leonis MA, Wagner LM, Tiao G, Ross ME. Chemoresistant Hepatoblastoma in a Patient with Mosaic Trisomy 18 Treated with Orthotopic Liver Transplantation. Peditr Blood Cancer. 2011;56:498-500.
Superina R, Magee J, Brandt M, Healey P, Tiao G, Ryckman F, Karrer F, Iyer K, Fecteau A, West K, Burns R, Flake A, Hammin L, Lowell J, Dillon P, Columbani P, Ricketts R, Yun L, Moore J, Kasper W. Childhood Liver Research and Education Network. AnnSurg. 2011.
Bondoc A, Taylor J, Alonso M, Nathan, J, Wang Y, Balistreri W, Bezerra J, Ryckman F, Tiao G. The Beneficial Impact of Revision of Kasai Portoenterostomy for Biliary Atresia: An Institutional Study. AnnSurg. 2012;255(3):570-6.
Wang W, Donnelly B, Bondoc A, Mohanty SK, McNeal M, Ward R, Sestak K, Zheng S, Tiao G. The rhesus rotavirus gene encoding VP4 is a major determinant in the pathogenesis of biliary atresia in newborn mice. J Virol. 2011 Jun.
Fernandez KS, Baum R, Fung B, Yeager N, Leonis MA, Wagner LM, Tiao G, Ross ME. Chemoresistant Hepatoblastoma in a Patient with Mosaic Trisomy 18 Treated with Orthotopic Liver Transplantation. Pediatr Blood Cancer. 2010;DOI 10.1002/pbc.22768.
Jafri M, Donnelly B, Bondoc A, Allen S, Tiao G. Cholangiocyte secretion of chemokines in experimental biliary atresia. J Pediatr Surg. 2009;44(3):500-7.
Bondoc AJ, Jafri MA, Donnelly B, Mohanty SK, McNeal MM, Ward, RL, Tiao GM. Prevention of the murine model of biliary atresia after live rotavirus vaccination of dams. J Pediatr Surg. 2009;44(8):1479-90.
The Molecular Determinants of Virus Induced Biliary Induced Biliary Asteria. Principal Investigator. Apr 2011 - Mar 2016.
Nycomed Liver Trial. Principal Investigator. 2012 - present. TC-2402-040-SP.
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