Show All

Acting Director

Andrew D. Hershey, MD, PhD, FAHS
Associate Director of Research, Division of Neurology

513-636-4222

andrew.hershey@cchmc.org

High Res

Andrew D. Hershey, MD, PhD, FAHS

Associate Director of Research, Division of Neurology

Professor, UC Department of Pediatrics

Phone: 513-636-4222

Fax: 513-636-3980

Email: andrew.hershey@cchmc.org

Show All

Specialties

Clinical Interests

Headaches; migraines; neurogenetics; neurometabolic disorders

Research Interests

Epidemiology; diagnositic criteria; treatment evaluation; outcome responses; quality of life issues; pharmaceutical trials; and neurogenetics of childhood headaches

Biography

Andrew Hershey, MD, PhD, received his undergraduate degree at the University of Iowa, Iowa City, Iowa. He earned an honors degree in Biochemistry; his research involved the enzyme kinetic properties of alcohol dehydrogenase in yeast.

After undergraduate school, Dr. Hershey attended the MD/PhD program at Washington University, St. Louis, Missouri. His Ph.D. research thesis was entitled: "The Rat Substance P Receptor: cDNA and Genomic Cloning, Functional Expression, mRNA Distribution, and Mutational Analysis of Desensitization Responses."

After earning his MD and PhD, Dr. Hershey was an intern and resident in pediatrics at St. Louis Children's Hospital, St. Louis, MO. He then was an adult neurology resident at Barnes-Jewish Hospital, St. Louis, MO, followed by his child neurology fellowship at St. Louis Children's Hospital, St. Louis, MO.

After his fellowship, Dr. Hershey joined the faculty at Cincinnati Children's Hospital Medical Center, Ohio, where he is director of the Headache Center.

Dr. Hershey's research interests currently include the improved diagnosis and treatment of childhood headache disorders, characterization of outcome responses, studies in new pharmacological and non-pharmacological treatment regimes, and the neurogenetics of migraines.

Education and Training

BS: University of Iowa, Iowa City, IA, 1985.

MD: Washington University, St. Louis, MO, 1992.

PhD: Washington University, St. Louis, MO, 1992.

Residency: St. Louis Childrens Hospital, St. Louis, MO, 1993-1994; Barnes-Jewish Hosptial, St. Louis, MO,1994-1995.

Fellowship: St. Louis Childrens Hospital, St. Louis, MO, 1995-1997.

Certification: Neurology with special competence in child neurology, 1998, recertified 2008; Headache Medicine, 2006.

Publications

View PubMed Publications

Hershey AD, Burdine D, Kabbouche MA, Powers SW. Genomic expression patterns in medication overuse headaches. Cephalalgia. 2011 Jan;31(2):161-71.

O'Brien HL, Kabbouche MA, Hershey AD. Treatment of acute migraine in the pediatric population. Curr Treat Options Neurol. 2010 May;12(3):178-85.

Hershey AD, Kabbouche MA, Powers SW.Treatment of pediatric and adolescent migraine.Pediatr Ann. 2010 Jul;39(7):416-23. doi: 10.3928/00904481-20100623-06. Review.

Wang X, Xiang J, Wang Y, Pardos M, Meng L, Huo X, Korostenskaja M, Powers SW, Kabbouche MA, Hershey AD. Identification of abnormal neuromagnetic signatures in the motor cortex of adolescent migraine. Headache. 2010 Jun;50(6):1005-16.

Hershey AD. Recent developments in pediatric headache. Curr Opin Neurol. 2010 Jun;23(3):249-53. Review.

Hershey AD. Current approaches to the diagnosis and management of paediatric migraine. Lancet Neurol. 2010 Feb;9(2):190-204. Review.

Slater S, Crawford MJ, Kabbouche MA, LeCates SL, Cherney S, Vaughan P, Segers A, Manning P, Burdine D, Powers SS, Hershey AD. Effects of gender and age on paediatric headache. Cephalalgia. 2009 Sep;29(9):969-73.

Khatri R, Hershey AD, Wong B. Prochlorperazine--treatment for acute confusional migraine. Headache. 2009 Mar;49(3):477-80.

Hershey AD. Menstrual migraine: how early can it start? Headache. 2009 Mar;49(3):348-9. Crawford MJ, Lehman L, Slater S, Kabbouche MA, LeCates SL, Segers A, Manning P, Powers SW, Hershey AD.

Menstrual migraine in adolescents. Headache. 2009 Mar;49(3):341-7.

Faculty

Todd M. Arthur, MD
Pediatric Epileptologist

513-636-4222

Jim Collins is an Assistant Professor and Attending Physician at Cincinnati Children's.

James (Jim) J. Collins, MD, PhD
Assistant Professor of Child Neurology

513-636-4222

james.collins@cchmc.org

High Res

James (Jim) J. Collins, MD, PhD

Assistant Professor of Child Neurology

Assistant Professor, UC Department of Pediatrics

Phone: 513-636-4222

Fax: 513-636-1888

Email: james.collins@cchmc.org

Show All

Specialties

Congenital muscular dystrophies; merosin-deficient congenital muscular dystrophy

Biography

James Collins MD, PhD obtained specialty training in Neuromuscular disorders at the Institute of Human Genetics, Centre for Life, University of Newcastle, Newcastle, UK, in the last months of his residency training. He was then appointed Assistant Professor at Cincinnati Children’s Hospital Medical Center where he follows patients in general Neurology and in the Comprehensive Neuromuscular Center.

Education and Training

PhD: Kent State University, Kent, OH 2000.

MD: University of Cincinnati, Cincinnati, OH 2004.

Residency: Pediatric Neurology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 2009.

Certification: Child Neurology, 2009.

Publications

View PubMed Publications

Collins J and Bönneman CG. Congenital Muscular Dystrophies: Toward Molecular Therapeutic Intervention. Current Neurology and Neuroscience Reports. 2010 Mar;10(2):83-91.

Collins J, Tang LY, Dimmock D, Morehart P, Bove K, Wong LJC, Wong B. Progressive myofiber changes of a childhood mitochondrial DNA depletion syndrome with a novel Thymidine Kinase 2 gene mutation. Neuromuscul Disord. 2009;19:784-787.

David Neal Franz, MD
Director, Tuberous Sclerosis Clinic

513-636-4222

franz@cchmc.org

High Res

David Neal Franz, MD

Director, Tuberous Sclerosis Clinic

Associate Director of Clinical Affairs, Division of Neurology

Professor, UC Department of Pediatrics

Phone: 513-636-4222

Fax: 513-636-1888

Email: franz@cchmc.org

Show All

Specialties

Tuberous sclerosis (adults and children); neuropharmacology; neurocutaneous disorders; general pediatric neurology

Biography

David Neal Franz, MD, was born and raised in Dayton, Ohio. He received his undergraduate degree in History and Literature from Earlham College in Richmond, Indiana.

After completing his training, he served as Assistant Professor of Neurology and Pediatrics at Wright State University before returning to Cincinnati Children's Hospital Medical Center.

He established the Cincinnati Tuberous Sclerosis Clinic in 1993, to assist in the medical care of patients who have or are suspected of having tuberous sclerosis. The purpose of the clinic is not to replace care from the child's pediatrician or family physician, but to assist the primary care physician in dealing with those aspects unique to tuberous sclerosis that affect the child's health or development. The basis of the clinic is the realization that people with tuberous sclerosis are different from other individuals who have epilepsy, learning disabilities, behavior problems, etc.

For too long, the unique problems found in this disease have been lumped together with similar disorders, despite the fact that research has shown that disorders of the brain, heart, kidney, and other organs in tuberous sclerosis are quite different.

Education and Training

MD: Ohio State University College of Medicine, Columbus, OH, 1985.

Residency: Wright State University Affiliated Hospitals, Dayton, OH.

Fellowship: Children's Hospital Medical Center, Cincinnati, OH.

Certification: Pediatrics, 1990; Neurology with special competence in child neurology, 1992.

Publications

View PubMed Publications

Franz DN, Bissler JJ, McCormack FX. Tuberous sclerosis complex: neurological, renal and pulmonary manifestations. Neuropediatrics. 2010 Oct;41(5):199-208.

Krueger DA, Care MM, Holland K, Agricola K, Tudor C, Mangeshkar P, Wilson KA, Byars A, Sahmoud T, Franz DN. Everolimus for subependymal giant-cell astrocytomas in tuberous sclerosis. N Engl J Med. 2010 Nov 4;363(19):1801-11.

Young LR, Vandyke R, Gulleman PM, Inoue Y, Brown KK, Schmidt LS, Linehan WM, Hajjar F, Kinder BW, Trapnell BC, Bissler JJ, Franz DN, McCormack FX. Serum vascular endothelial growth factor-D prospectively distinguishes lymphangioleiomyomatosis from other diseases. Chest. 2010 Sep;138(3):674-81.

Young LR, Franz DN, Nagarkatte P, Fletcher CD, Wikenheiser-Brokamp KA, Galsky MD, Corbridge TC, Lam AP, Gelfand MJ, McCormack FX. Utility of [18F]2-fluoro-2-deoxyglucose-PET in sporadic and tuberous sclerosis-associated lymphangioleiomyomatosis. Chest. 2009 Sep;136(3):926-33.

Schmithorst VJ, Altes TA, Young LR, Franz DN, Bissler JJ, McCormack FX, Dardzinski BJ, Brody AS. Automated algorithm for quantifying the extent of cystic change on volumetric chest CT: initial results in Lymphangioleiomyomatosis. AJR Am J Roentgenol. 2009 Apr;192(4):1037-44.

Krueger DA, Franz DN. Current management of tuberous sclerosis complex. Paediatr Drugs. 2008;10(5):299-313. Review.

Bissler JJ, McCormack FX, Young LR, Elwing JM, Chuck G, Leonard JM, Schmithorst VJ, Laor T, Brody AS, Bean J, Salisbury S, Franz DN. Sirolimus for angiomyolipoma in tuberous sclerosis complex or lymphangioleiomyomatosis. N Engl J Med. 2008 Jan 10;358(2):140-51.

Levine NB, Collins J, Franz DN, Crone KR. Gradual formation of an operative corridor by balloon dilation for resection of subependymal giant cell astrocytomas in children with tuberous sclerosis: specialized minimal access technique of balloon dilation. Minim Invasive Neurosurg. 2006 Oct;49(5):317-20.

Collins JJ, Tudor C, Leonard JM, Chuck G, Franz DN. Levetiracetam as adjunctive antiepileptic therapy for patients with tuberous sclerosis complex: a retrospective open-label trial. J Child Neurol. 2006 Jan;21(1):53-7.

Franz DN, Leonard J, Tudor C, Chuck G, Care M, Sethuraman G, Dinopoulos A, Thomas G, Crone KR. Rapamycin causes regression of astrocytomas in tuberous sclerosis complex. Ann Neurol. 2006 Mar;59(3):490-8.

Donald L. Gilbert, MD, MS
Director, Movement Disorder Clinic and Tourette's Syndrome Clinic

513-636-4222

donald.gilbert@cchmc.org

High Res

Donald L. Gilbert, MD, MS

Director, Movement Disorder Clinic and Tourette's Syndrome Clinic

Professor, UC Department of Pediatrics

Phone: 513-636-4222

Fax: 513-636-3980

Email: donald.gilbert@cchmc.org

Show All

Specialties

Clinical Interests

Movement disorders; Tourette's Syndrome; Sydenham's Chorea; kernicterus; dystonia; ataxia; clinical research; transcranial magnetic stimulation

Research Interests

Clinical trials in Tourette's Syndrome and associated ADHD; epidemiology of Tourette's Syndrome and PANDAS; clinical effectiveness of multi-drug treatments in Tourette's Syndrome; transcranial magnetic stimulation in Tourette's Syndrome and pediatric movement disorders; functional neurosurgery for pediatric dystonia

Visit the Gilbert-Wu Lab.

Biography

Donald Gilbert, MD, earned his Bachelor of Arts at Princeton University, where he majored in philosophy. He subsequently earned his MD at the University of Michigan and spent a year at the National Institutes of Health as a Howard Hughes Medical Institute Research Scholar. Dr. Gilbert did his pediatrics and neurology training at John Hopkins in Baltimore and is board certified in neurology with special competence in child neurology. Dr. Gilbert has an MS in Clinical Research Design and Statistical Analysis from the University of Michigan.

At Cincinnati Children's, Dr. Gilbert directs the Movement Disorders and Tourette's Syndrome Clinics, which specialize in evaluation and pharmacologic treatment of tics, chorea, tremor, dystonia, stereotypies, ataxia, and other movement disorders. Dr. Gilbert directs or participates in a number of single and multi-center studies into causes and treatments of Tourette's Syndrome. Dr. Gilbert directs the Transcranial Magnetic Stimulation Laboratory at CCHMC.

Education and Training

BA: Princeton University, Princeton, NJ, 1987.

MD: University of Michigan School of Medicine, Ann Arbor, MI, 1993.

MS: University of Michigan, Ann Arbor, MI, 2003.

Residency: Johns Hopkins School of Medicine, Baltimore, MD, 1995.

Fellowship: Johns Hopkins School of Medicine, Baltimore, MD, 1995.

Certification: Board Certified in Neurology with Special Competence in Child Neurology, 2010. Board eligible in Pediatrics.

Appointment: Associate Professor of Pediatric Neurology.

Publications

View PubMed Publications

Ridel KR, Gilbert DL. Child neurology: past, present, and future: part 3: the future. Neurology. 2010 Oct 12;75(15):e62-4.

Wu SW, Harris E, Gilbert DL. Tic suppression: the medical model. J Child Adolesc Psychopharmacol. 2010 Aug;20(4):263-76.

Dalal P, Leslie ND, Lindor NM, Gilbert DL, Espay AJ. Motor tics, stereotypies, and self-flagellation in primrose syndrome. Neurology. 2010 Jul 20;75(3):284-6.

Ridel KR, Lipps TD, Gilbert DL. The prevalence of neuropsychiatric disorders in Sydenham's chorea. Pediatr Neurol. 2010 Apr;42(4):243-8.

Hopkins SE, Somoza A, Gilbert DL. Rare autosomal dominant POLG1 mutation in a family with metabolic strokes, posterior column spinal degeneration, and multi-endocrine disease. J Child Neurol. 2010 Jun;25(6):752-6.

Degrauw RS, Li JZ, Gilbert DL. Body mass index changes and chronic neuroleptic drug treatment for Tourette syndrome. Pediatr Neurol. 2009 Sep;41(3):183-6.

Gilbert DL. Acute and chronic chorea in childhood. Semin Pediatr Neurol. 2009 Jun;16(2):71-6. Review.

Wong B, Gilbert DL, Walker WL, Liao IH, Lit L, Stamova B, Jickling G, Apperson M, Sharp FR. Gene expression in blood of subjects with Duchenne muscular dystrophy. Neurogenetics. 2009 Apr;10(2):117-25.

Gilbert DL, Leslie EJ, Keddache M, Leslie ND. A novel hereditary spastic paraplegia with dystonia linked to chromosome 2q24-2q31. Mov Disord. 2009 Feb 15;24(3):364-70.

Gilbert DL. Drug-induced movement disorders in children. Ann N Y Acad Sci. 2008 Oct;1142:72-84. Review.

Tracy A. Glauser, MD
Director, Comprehensive Epilepsy Center

513-636-4222

tracy.glauser@cchmc.org

High Res

Tracy A. Glauser, MD

Director, Comprehensive Epilepsy Center

Co-Director, Genetic Pharmacology Service

Professor, UC Department of Pediatrics

Phone: 513-636-4222

Fax: 513-636-3980

Email: tracy.glauser@cchmc.org

Show All

Specialties

Clinical Interests

Epilepsy; pharmacogenetics; clinical pharmacology

Research Interests

Clinical pharmacology; pharmacogenetics; antiepileptic clinical trials

Biography

Tracy A. Glauser, MD, is Professor of Pediatrics, director of the Comprehensive Epilepsy Center and co-Director of the Genetic Pharmacology Service at Cincinnati Children’s Hospital Medical Center. Dr Glauser received his medical degree, cum laude, from Jefferson Medical College in Philadelphia, PA. He completed his residency in pediatrics at the John Hopkins Hospital in Baltimore, MD, and fellowship in child neurology at The Children’s Hospital of Philadelphia, University of Pennsylvania in Philadelphia, PA. Dr Glauser completed a National Institute of Neurological Disorders and Stroke research fellowship in pediatric neurology and was a fellow in epilepsy and electroencephalography at St. Louis Children’s Hospital, Washington University School of Medicine in St. Louis, Missouri.

Dr Glauser has authored and co-authored more than 130 articles and book chapters, been involved with the development of 6 evidence based guidelines about epilepsy therapy and given over 150 invited lectures throughout the world. He has been the principal investigator on multiple NIH grants. Currently, Dr Glauser directs the NIH funded Childhood Absence Epilepsy clinical trial involving 32 pediatric centers around the United States. Dr Glauser’s fields of expertise are pediatric neurology, pediatric epilepsy, clinical pharmacology, and pharmacogenetics.

Education and Training

MD: Jefferson Medical College, Philadelphia, PA, 1985.

Residency: Johns Hopkins Hospital, Baltimore, MD.

Fellowship: St. Louis Children's Hospital, St. Louis, MO.

Certification: Pediatrics, 1990; Neurology (with special competence in child neurology), 1991.

Publications

View PubMed Publications

Modi AC, Guilfoyle SM, Morita DA, Glauser TA. Development and reliability of a correction factor for parent-reported adherence to pediatric antiepileptic drug therapy. Epilepsia. 2010 Nov 18. doi: 10.1111/j.1528-1167.2010.02789.x.

Modi AC, Monahan S, Daniels D, Glauser TA. Development and validation of the Pediatric Epilepsy Medication Self-Management Questionnaire. Epilepsy Behav. 2010 May;18(1-2):94-9

Glauser TA, Cnaan A, Shinnar S, Hirtz DG, Dlugos D, Masur D, Clark PO, Capparelli EV, Adamson PC; Childhood Absence Epilepsy Study Group. Ethosuximide, valproic acid, and lamotrigine in childhood absence epilepsy. N Engl J Med. 2010 Mar 4;362(9):790-9.

Holland KD, Monahan S, Morita D, Vartzelis G, Glauser TA. Valproate in children with newly diagnosed idiopathic generalized epilepsy. Acta Neurol Scand. 2010 Mar;121(3):149-53.

Pestian J, Spencer M, Matykiewicz P, Zhang K, Vinks AA, Glauser T. Personalizing Drug Selection Using Advanced Clinical Decision Support.Biomed Inform Insights. 2009 Jun 23;2:19-29.

Prows CA, Nick TG, Saldaña SN, Pathak S, Liu C, Zhang K, Daniels ZS, Vinks AA, Glauser TA. Drug-metabolizing enzyme genotypes and aggressive behavior treatment response in hospitalized pediatric psychiatric patients. J Child Adolesc Psychopharmacol. 2009 Aug;19(4):385-94.

Modi AC, King AS, Monahan SR, Koumoutsos JE, Morita DA, Glauser TA. Even a single seizure negatively impacts pediatric health-related quality of life. Epilepsia. 2009 Sep;50(9):2110-6.

Daniels ZS, Nick TG, Liu C, Cassedy A, Glauser TA. Obesity is a common comorbidity for pediatric patients with untreated, newly diagnosed epilepsy. Neurology. 2009 Sep 1;73(9):658-64.

Glauser TA, Sankar R; Co-chairs of the Leadership in Epilepsy, Advocacy, and Development Faculty. Core elements of epilepsy diagnosis and management: expert consensus from the Leadership in Epilepsy, Advocacy, and Development (LEAD) faculty. Curr Med Res Opin. 2008 Dec;24(12):3463-77.

Glauser T, Kluger G, Sachdeo R, Krauss G, Perdomo C, Arroyo S. Rufinamide for generalized seizures associated with Lennox-Gastaut syndrome. Neurology. 2008 May 20;70(21):1950-8.

Grants

Sodium channel gene variation in the treatment of epilepsy. Collaborator. Apr 2009 - Mar 2014. #R01NS062756.

The epilepsy phenome/ genome project (EPGP). Pharmacogenetics Core/Site Principal Investigator. May 2007- Apr 2012. #R01NS053998.

Hansel M Greiner, MD
Pediatric Epileptologist

513-636-4222

hansel.greiner@cchmc.org

Barbara E. Hallinan, MD, PhD
Pediatric Neurologist

513-636-4222

High Res

Barbara E. Hallinan, MD, PhD

Pediatric Neurologist

Assistant Professor, UC Department of Pediatrics

Phone: 513-636-4222

Fax: 513-636-1888

Show All

Specialties

Infantile epilepsy

Education and Training

PhD: Florida State University, Tallahassee, FL, 1989.

MD: University of Cincinnati College of Medicine, Cincinnati, OH, 2001.

Residency: Cincinnati Children's Hospital Medical Center, Cincinnati, OH.

Certification: Pediatrics, 2007; Neurology with Special Qualification in Child Neurology, 2007.

Publications

View PubMed Publications

Dent CL, Spaeth JP, Jones BV, Schwartz SM, Glauser TA, Hallinan B, Pearl JM, Khoury PR, Kurth CD. Brain magnetic resonance imaging abnormalities after the Norwood procedure using regional cerebral perfusion. J Thorac Cardiovasc Surg. 2006 Jan;131(1):190-7. Retraction in: J Thorac Cardiovasc Surg. 2006 Jun;131(6):1226.

Andrew D. Hershey, MD, PhD, FAHS
Associate Director of Research, Division of Neurology

513-636-4222

andrew.hershey@cchmc.org

High Res

Andrew D. Hershey, MD, PhD, FAHS

Associate Director of Research, Division of Neurology

Professor, UC Department of Pediatrics

Phone: 513-636-4222

Fax: 513-636-3980

Email: andrew.hershey@cchmc.org

Show All

Specialties

Clinical Interests

Headaches; migraines; neurogenetics; neurometabolic disorders

Research Interests

Epidemiology; diagnositic criteria; treatment evaluation; outcome responses; quality of life issues; pharmaceutical trials; and neurogenetics of childhood headaches

Biography

After his fellowship, Dr. Hershey joined the faculty at Cincinnati Children's Hospital Medical Center, Ohio, where he is director of the Headache Center.

Education and Training

Publications

View PubMed Publications

Hershey AD, Burdine D, Kabbouche MA, Powers SW. Genomic expression patterns in medication overuse headaches. Cephalalgia. 2011 Jan;31(2):161-71.

O'Brien HL, Kabbouche MA, Hershey AD. Treatment of acute migraine in the pediatric population. Curr Treat Options Neurol. 2010 May;12(3):178-85.

Hershey AD, Kabbouche MA, Powers SW.Treatment of pediatric and adolescent migraine.Pediatr Ann. 2010 Jul;39(7):416-23. doi: 10.3928/00904481-20100623-06. Review.

Hershey AD. Recent developments in pediatric headache. Curr Opin Neurol. 2010 Jun;23(3):249-53. Review.

Hershey AD. Current approaches to the diagnosis and management of paediatric migraine. Lancet Neurol. 2010 Feb;9(2):190-204. Review.

Katherine D. Holland-Bouley, MD, PhD
Pediatric Epileptologist

katherine.holland@cchmc.org

High Res

Katherine D. Holland-Bouley, MD, PhD

Pediatric Epileptologist

Assistant Professor, UC Department of Pediatrics

Email: katherine.holland@cchmc.org

Show All

Specialties

Mechanisms of epileptogenisis

Education and Training

MD: Washington University, St Louis MO, 1991.

PhD (pharmacology): Washington University, St Louis MO, 1991.

Internship: Children's Hospital, Boston MA.

Residency: St Louis Children's Hospital, St Louis, MO.

Certification: Neurology with added qualification in pediatric neurology, 2000.

Publications

View PubMed Publications

Standridge SM, Holland KD, Horn PS. Cardiac arrhythmias and ictal events within an epilepsy monitoring unit. Pediatr Neurol. 2010 Mar;42(3):201-5.

Holland KD, Monahan S, Morita D, Vartzelis G, Glauser TA. Valproate in children with newly diagnosed idiopathic generalized epilepsy. Acta Neurol Scand. 2010 Mar;121(3):149-53.

Holland KD, Kearney JA, Glauser TA, Buck G, Keddache M, Blankston JR, Glaaser IW, Kass RS, Meisler MH. Mutation of sodium channel SCN3A in a patient with cryptogenic pediatric partial epilepsy. Neurosci Lett. 2008 Mar 5;433(1):65-70.

Holland KD, Glauser TA. Response to carbamazepine in children with newly diagnosed partial onset epilepsy. Neurology. 2007 Aug 7;69(6):596-9.

Holland KD, Fleming MT, Cheek S, Moran JL, Beier DR, Meisler MH. De novo exon duplication in a new allele of mouse Glra1 (spasmodic). Genetics. 2006 Dec;174(4):2245-7.

Sarah E. Hopkins, MD
Pediatric Neurologist

513-636-4222

sarah.hopkins@cchmc.org

Sejal Jain, MD
Pediatric Epileptologist

513-636-4222

sejal.jain@cchmc.org

High Res

Sejal Jain, MD

Pediatric Epileptologist

Assistant Professor, UC Department of Pediatrics

Phone: 513-636-4222

Fax: 513-636-1888

Email: sejal.jain@cchmc.org

Show All

Specialties

Epilepsy; sleep disorders

Education and Training

MD: Gujarat University, India.

Residency: Nassau University Medical Center, NY.

Fellowships: Clinical Neurophysiology and Pediatric Neurology, Virginia Commonwealth University, Richmond, Virginia; Sleep Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.

Certifications: Neurology (Child Neurology); Clinical Neurophysiology.

Publications

View PubMed Publications

Jain SV, Simakajornboon S, Shapiro SM, Morton LD, Leszczyszyn DJ, Simakajornboon. Obstructive Sleep Apnea in Children with Epilepsy: Prospective Pilot Trial. Acta Neurologica Scandinavica. 2011 March 17. Epub ahead of print.

Jain SV, Morton LD. Ischemic stroke and excellent recovery after intravenous tissue plasminogen activator. Pediatric Neurology. 2008;38:126-129.

Book Chapters

Jain SV, Morton LD. Evaluating the child with seizure: In Pellock JM, Dodson EW, Bourgeois BF, and Nordlii DR: Pediatric Epilepsy, diagnosis and treatment. New York: Demos Medical Publishing, 2007.

Grants

Melatonin and sleep in refractory epilepsy. Principal Investigator. Center for Clinical and Translational Science and Training, Cincinnati Children's Hospital Medical Center. Jul 2010 - Jul 2012.

Melatonin and sleep in refractory epilepsy. Principal Investigator. National Institutes of Health. Apr 2010 - Apr 2012. #UL1RR026314.

Marielle A. Kabbouche, MD
Child Neurologist

513-636-4222

marielle.kabbouche@cchmc.org

High Res

Marielle A. Kabbouche, MD

Child Neurologist

Associate Professor, UC Department of Pediatrics

Phone: 513-636-4222

Fax: 513-636-1888

Email: marielle.kabbouche@cchmc.org

Show All

Specialties

Clinical Interests

Headaches; migraines; cute and inpatient treatment of intractable headache

Research Interests

Headache; outcome studies; health improvement; cinical effectiveness

Biography

Marielle Kabbouche, MD, received her training in Child Neurology at Vanderbilt University school of medicine. She moved to Cincinnati for a specialty training in pediatric headache medicine . The position was the first for a pediatric neurologist.

After her headache training she stayed at Cincinnati Children's as faculty and active member of the center with involvement in all academic as well as clinical and teaching aspect of pediatric headache. Since that time she has been proud to be part of the maturing center that gradually developed to be the largest and most academically productive pediatric headache program in the United States and worldwide. She has been a co- PI on multiple NIH grants since 2002 and have been involved in multiple pharmaceutical and clinical studies in pediatric and adolescent migraine.

Her carrier has been focused on acute treatment of intractable Migraine in Children in emergency room as well as inpatient settings.

As the Director of the inpatient headache unit, Dr. Kabbouche was actively involved in setting an acute headache infusion center as well as an inpatient headache unit at Cincinnati Children’s Hospital Medical Center. The Headache acute care unit has been very productive in the last few years and seeing about 200-300 patients/year during peak seasons. The inpatient unit will open in July of 2011 bringing specialty care to the headache patients with a team of 6 providers , fellows , residents and nurses. This approach to intractable headache care will have a great impact on patient’s outcome.

Dr. Kabbouche has over 25 publications, and a track record of numerous peer-reviewed papers, reviews, and abstracts in the field of headache medicine, book chapters as well as being an editor of a pediatric headache book.

Education and Training

MD: Saint Joseph University, Faculty of Medicine, Beirut, Lebanon.

Residency: Vanderbilt University Medical Center, Nashville, TN.

Fellowship: Cincinnati Children's Hospital, Cincinnati, OH.

Publications

View PubMed Publications

Hershey AD, Kabbouche MA, Powers SW. Treatment of pediatric and adolescent migraine. Pediatr Ann. 2010 Jul;39(7):416-23.

Kabbouche MA, Cleves C. Evaluation and management of children and adolescents presenting with an acute setting. Semin Pediatr Neurol. 2010 Jun;17(2):105-8.

Kabbouche MA, Powers SW, Segers A, LeCates S, Manning P, Biederman S, Vaughan P, Burdine D, Hershey AD. Inpatient treatment of status migraine with dihydroergotamine in children and adolescents. Headache. 2009 Jan;49(1):106-9.

Kabbouche MA, Gilman DK. Management of migraine in adolescents. Neuropsychiatr Dis Treat. 2008 Jun;4(3):535-48.

Kabbouche MA, Linder SL. Management of migraine in children and adolescents in the emergency department and inpatient setting. Curr Pain Headache Rep. 2005 Oct;9(5):363-7.

Kabbouche MA, Linder SL. Acute treatment of pediatric headache in the emergency department and inpatient settings. Pediatr Ann. 2005 Jun;34(6):466-71.

Kabbouche MA, Powers SW, Vockell ALB, LeCates SL, Ellinor PL, Segers A, Manning P, Hershey AD. Outcome of a multidisciplinary approach of pediatric migraine at 1, 2, and 5 years. Headache. 2005;45:1298-1303.

Book Chapters

Kabbouche MA. Migraine variants. In Andrew Hershey, Scott Powers, Paul Winners and Marielle Kabbouche (Eds.) Pediatric Headache in Clinical Practice. Wiley Blackwell, 2009.

Kabbouche MA. Other primary headaches. In Andrew Hershey, Scott Powers, Paul Winners and Marielle Kabbouche (Eds.) Pediatric Headache in Clinical Practice. Wiley Blackwell, 2009.

Kabbouche MA. Emergent therapy for children and adolescent. In Andrew Hershey, Scott Powers, Paul Winners and Marielle Kabbouche (Eds.) Pediatric Headache in Clinical Practice. Wiley Blackwell, 2009.

Grants

Acute treatment of headaches in children and adolescents. Co-Principal Investigator. American Headache Society. 2007 - 2012.

Drug & Non-Drug Treatment of Pediatric Chronic Headache. Co-Investigator. National Institute of Neurological Disorders and Stroke. 2006 - 2011. #R01 NS050536-01A1.

Darcy A. Krueger, MD, PhD

513-636-4222

krueger_darcy@cchmc.org

High Res

Darcy A. Krueger, MD, PhD

Assistant Professor, UC Department of Pediatrics

Phone: 513-636-4222

Email: krueger_darcy@cchmc.org

Show All

Specialties

Clinical Interests

Tuberous sclerosis; general neurology

Research Interests

Tuberous sclerosis; clinical use of mTOR inhibitors; role of mTOR pathway in neurological disease

Education and Training

MD: Saint Louis University School of Medicine, St. Louis, Missouri, 1995-1997; 2000-2002.

PhD: Saint Louis University Graduate School Biochemistry and Molecular Biology, St. Louis, Missouri, 1997-2000.

Publications

View PubMed Publications

Greiner H, Leach JL, Lee KH, Krueger DA. Anti-NMDA receptor encephalitis presenting with imaging findings and clinical features mimicking Rasmussen syndrome. Seizure. 2011 Apr;20(3):266-70.

Krueger DA, Care MM, Holland K, Agricola K, Tudor C, Mangeshkar P, Wilson KA, Byars A, Sahmoud T, Franz DN. Everolimus for subependymal giant-cell astrocytomas in tuberous sclerosis. N Engl J Med. 2010 Nov 4;363(19):1801-11.

Krueger DA, Franz DN. Current management of tuberous sclerosis complex. Paediatr Drugs. 2008;10(5):299-313.

Michael V. Miles, PharmD
Director, Neuropharmacology Laboratory

513-636-7871

michael.miles@cchmc.org

High Res

Michael V. Miles, PharmD

Director, Neuropharmacology Laboratory

Professor, UC Department of Pediatrics

Phone: 513-636-7871

Fax: 513-636-1888

Email: michael.miles@cchmc.org

Show All

Specialties

Pediatric pharmacology; laboratory tests and biomarkers for monitoring mitochondrial function and oxidative stress; mitochondrial abnormalities associated with aging, obesity, sleep apnea, epilepsy and nutritional deficiencies; safety and efficacy of treatment with antioxidants, such as coenzyme Q and vitamin E.

Biography

Michael V. Miles, PharmD, has been a member of the Division of Pediatric Neurology for over 5 years. He is an experienced clinician and researcher, who has studied the pharmacokinetics and pharmacodynamics of drugs in pediatric populations for much of his career. He has dedicated his clinical and research efforts to improving the efficacy and safety of drug therapy for infants and children. His research is currently focused on the development of new biomarkers and therapeutic agents for patients with mitochondrial diseases.

Education and Training

PharmD: University of Texas at Austin, Austin, Texas, 1979.

Specialty Residency: Pediatric Clinical Pharmacy, University of Texas at Austin, Austin, Texas.

Certification: Pharmacy, 1976.

Publications

View PubMed Publications

Miles MV, Putnam PE, Miles L, Tang PH, DeGrauw AJ, Wong BL, Horn PS, Foote HL, Rothenberg ME. Acquired coenzyme Q10 deficiency in children with recurrent food intolerance and allergies. Mitochondrion. 2011 Jan;11(1):127-35.

Kohli R, Kirby M, Xanthakos SA, Softic S, Feldstein AE, Saxena V, Tang PH, Miles L, Miles MV, Balistreri WF, Woods SC, Seeley RJ. High-fructose, medium chain trans fat diet induces liver fibrosis and elevates plasma coenzyme Q9 in a novel murine model of obesity and nonalcoholic steatohepatitis.Hepatology. 2010 Sep;52(3):934-44.

Miles MV, Tang PH, Miles L, Steele PE, Moye MJ, Horn PS. Validation and application of an HPLC-EC method for analysis of coenzyme Q10 in blood platelets.Biomed Chromatogr. 2008 Dec;22(12):1403-8.

Miles MV, Miles L, Tang PH, Horn PS, Steele PE, DeGrauw AJ, Wong BL, Bove KE. Systematic evaluation of muscle coenzyme Q10 content in children with mitochondrial respiratory chain enzyme deficiencies. Mitochondrion. 2008 Mar;8(2):170-80.

Miles MV, Patterson BJ, Chalfonte-Evans ML, Horn PS, Hickey FJ, Schapiro MB, Steele PE, Tang PH, Hotze SL. Coenzyme Q10 (ubiquinol-10) supplementation improves oxidative imbalance in children with trisomy 21.Pediatr Neurol. 2007 Dec;37(6):398-403.

Miles MV. The uptake and distribution of coenzyme Q10. Mitochondrion. 2007 Jun;7 Suppl:S72-7.

Tang PH, Miles MV, Steele P, Davidson BS, Geraghty SR, Morrow AL. Determination of coenzyme Q10 in human breast milk by high-performance liquid chromatography.Biomed Chromatogr. 2006 Dec;20(12):1336-43.

Miles MV, Patterson BJ, Schapiro MB, Hickey FJ, Chalfonte-Evans M, Horn PS, Hotze SL. Coenzyme Q10 absorption and tolerance in children with Down syndrome: a dose-ranging trial.Pediatr Neurol. 2006 Jul;35(1):30-7.

Miles L, Miles MV, Tang PH, Horn PS, Quinlan JG, Wong B, Wenisch A, Bove KE. Ubiquinol: a potential biomarker for tissue energy requirements and oxidative stress.Clin Chim Acta. 2005 Oct;360(1-2):87-96.

Miles L, Miles MV, Tang PH, Horn PS, Wong BL, DeGrauw TJ, Morehart PJ, Bove KE. Muscle coenzyme Q: a potential test for mitochondrial activity and redox status.Pediatr Neurol. 2005 May;32(5):318-24.

Diego A. Morita, MD
Co-Director, New Onset Seizure Clinic

513-636-4222

diego.morita@cchmc.org

Quick Links

Quick Links

Quick Links

Quick Links

Quick Links

Add to MyPages

E-mail this page

Share this on:

Sign into CCHMC

Neurology

Neurology

Meet the Team

Acting Director

Andrew D. Hershey, MD, PhD, FAHS

Specialties

Clinical Interests

Research Interests

Biography

Education and Training

Publications

Faculty

Todd M. Arthur, MD

Specialties

Education and Training

James (Jim) J. Collins, MD, PhD

Specialties

Biography

Education and Training

Publications

David Neal Franz, MD

Specialties

Biography

Education and Training

Publications

Donald L. Gilbert, MD, MS

Specialties

Clinical Interests

Research Interests

Biography

Education and Training

Publications

Tracy A. Glauser, MD

Specialties

Clinical Interests

Research Interests

Biography

Education and Training

Publications

Grants

Hansel M Greiner, MD

Specialties

Education and Training

Publications

Barbara E. Hallinan, MD, PhD

Specialties

Education and Training

Publications

Andrew D. Hershey, MD, PhD, FAHS

Specialties

Clinical Interests

Research Interests

Biography

Education and Training

Publications

Katherine D. Holland-Bouley, MD, PhD

Specialties

Education and Training

Publications

Sarah E. Hopkins, MD

Publications

Sejal Jain, MD

Specialties

Education and Training

Publications

Book Chapters

Grants

Marielle A. Kabbouche, MD

Specialties

Clinical Interests

Research Interests