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The Neuromuscular Cardiology team is home to specialists with a wide variety of backgrounds and areas of focus. As a team, this diversity makes us better prepared to care for your child’s unique needs. Learn more about our co-directors and staff.
John Lynn Jefferies, MD, MPH, FAAP, FACC Director, Advanced Heart Failure and Cardiomyopathy 513-803-1675 firstname.lastname@example.org
Director, Advanced Heart Failure and Cardiomyopathy
Associate Professor, UC Department of Pediatrics
Dr. Jefferies, an associate professor of pediatric cardiology and adult cardiovascular diseases within the University of Cincinnati College of Medicine, is the director of Advanced Heart Failure / Cardiomyopathy in the Heart Institute at Cincinnati Children's Hospital Medical Center.
He completed his combined pediatric and adult cardiology training at the Baylor College of Medicine in Houston, Texas at the Texas Children's Hospital and the Texas Heart Institute. He has authored or co-authored over 120 peer-reviewed manuscripts and book chapters on cardiomyopathy, cardiovascular genetics, and adults with congenital heart disease.
His current research interests include heritable causes of cardiovascular disease, novel drug therapies for advanced heart failure, novel gene discovery in cardiomyopathy, characterization and management of left ventricular noncompaction (LVNC), and early diagnosis and management of chemotherapy induced cardiotoxicity.
He is on the editorial board of the Texas Heart Institute Journal and is an active member of numerous professional organizations, including the Heart Failure Society of America, the American College of Cardiology and the American Heart Association. He is the lead editor for two textbooks that focus on the management of heart disease in children and young adults entitled “Heart Failure in the Child and Young Adult: From Bench to Bedside” and “Cardioskeletal Myopathies in Children and Young Adults.”
BS: University of Tennessee, Knoxville, TN, 1992.
MD: University of Tennessee, Knoxville, TN, 1996.
Residency: University of Kentucky, Lexington, KY, 2000.
MPH: University of Kentucky, Lexington, KY, 2001.
Fellowship: Baylor College of Medicine, Houston, TX, 2006.
Certification: Pediatrics, Internal Medicine, Cardiology, Advanced Heart Failure, Cardiac Transplant.
Towbin JA, Lorts A, Jefferies JL. Left ventricular noncompaction cardiomyopathy. Lancet. 2015;Apr 9. Epub ahead of print.
McCullough PA, Jefferies JL. Novel Markers And Therapies For Patients With Acute Heart Failure And Renal Dysfunction. Am J Med. 2015 Mar;128(3):312.e1-22.
Villa CR, Ryan TD, Collins JJ, Taylor MD, Lucky AW, Jefferies JL. Left ventricular non-compaction cardiomyopathy associated with epidermolysis bullosa simplex with muscular dystrophy and PLEC1 mutation. Neuromuscul Disord. 2015 Feb;25(2):165-8.
Raman SV, Hor KN, Halnon NJ, Kissel JT, He X, Tran T, Smart S, McCarthy B, Taylor MD, Jefferies JL, Rafael-Fortney JA, Lowe J, Roble SL, Cripe LH. Eplerenone for early cardiomyopathy in Duchenne muscular dystrophy: a randomised, double-blind, placebo-controlled trial. Lancet Neurol. 2015 Feb;14(2):153-61.
Jefferies JL. Barth syndrome. Am J Med Genet C Semin Med Genet. 2013 Aug;163C(3):198-205.
Breinholt JP, Moulik M, Dreyer WJ, Denfield SW, Kim JJ, Jefferies JL, Rossano JW, Gates CM, Clunie SK, Bowles KR, Kearney DL, Bowles NE, Towbin JA. Viral epidemiologic shift in inflammatory heart disease: the increasing involvement of parvovirus B19 in the myocardium of pediatric cardiac transplant patients. J Heart Lung Transplant. 2010 Jul;29(7):739-46.
Carlson P, Jefferies JL, Kearney D, Russell H. Refractory dilated cardiomyopathy associated with metastatic neuroblastoma. Pediatr Blood Cancer. 2010 Jun 29.
Shah AM, Jefferies JL, Rossano JW, Decker JA, Cannon BC, Kim JJ. Electrocardiographic abnormalities and arrhythmias are strongly associated with the development of cardiomyopathy in muscular dystrophy. Heart Rhythm. 2010 Jun 18.
Rossano JW, Morales DL, Zafar F, Denfield SW, Kim JJ, Jefferies JL, Dreyer WJ. Impact of antibodies against human leukocyte antigens on long-term outcome in pediatric heart transplant patients: An analysis of the United Network for Organ Sharing database. J Thorac Cardiovasc Surg. 2010 May 26.
Brenda Wong, MD, MBBS Director, Comprehensive Neuromuscular Center/MDA Clinic 513-636-4222 email@example.com
Director, Comprehensive Neuromuscular Center/MDA Clinic
Professor, UC Department of Pediatrics
UC Department of Neurology and Rehabilitation Medicine
After medical school, Brenda Wong, MD, received training in general pediatrics and worked as a pediatrician for a few years before doing her three-year child neurology fellowship at Cincinnati Children's Hospital Medical Center.
Dr. Wong also received training in pediatric neuromuscular disorders at Hammersmith Hospital, London with Dr. Victor Dubowitz and Dr. Francesco Muntoni. Dr. Wong's training in EMGs was accomplished with Dr. John Quinlan in the Department of Neurology at the University of Cincinnati.
Post fellowship training, Dr. Wong was practicing child neurology in private practice prior to joining Cincinnati Children's in 1999.
Besides general neurology patients, Dr. Wong sees patients with neuromuscular disorders in the Neuromuscular Clinic and provide diagnostic services like EMGs and evaluation for muscle biopsies. Comprehensive management is supported by the Division of Rehabilitative Medicine, Pulmonary Medicine, Pediatric Orthopedics and the Muscular Dystrophy Association.
MD: University of Singapore, 1980.
Residency: University Department of Pediatrics, Singapore, 1981, 1984-85; Royal Hospital for Sick Children, Edinburgh, 1985-88.
Fellowship: Child Neurology, Children's Hospital Medical Center, Cincinnati, OH, 1994-97; Neuromuscular Disorders, Hammersmith Hospital, London, 1997.
Certification: Child Neurology, 1998.
Miles MV, Putnam PE, Miles L, Tang PH, DeGrauw AJ, Wong BL, Horn PS, Foote HL, Rothenberg ME. Acquired coenzyme Q10 deficiency in children with recurrent food intolerance and allergies. Mitochondrion. 2011 Jan;11(1):127-35.
Kim HK, Laor T, Horn PS, Racadio JM, Wong B, Dardzinski BJ. T2 mapping in Duchenne muscular dystrophy: distribution of disease activity and correlation with clinical assessments. Radiology. 2010 Jun;255(3):899-908.
Kim HK, Laor T, Horn PS, Wong B. Quantitative assessment of the T2 relaxation time of the gluteus muscles in children with Duchenne muscular dystrophy: a comparative study before and after steroid treatment. Korean J Radiol. 2010 May-Jun;11(3):304-11.
Yang Z, Funke BH, Cripe LH, Vick GW 3rd, Mancini-Dinardo D, Peña LS, Kanter RJ, Wong B, Westerfield BH, Varela JJ, Fan Y, Towbin JA, Vatta M. LAMP2 microdeletions in patients with Danon disease Circ Cardiovasc Genet. 2010 Apr;3(2):129-37.
Henderson RC, Berglund LM, May R, Zemel BS, Grossberg RI, Johnson J, Plotkin H, Stevenson RD, Szalay E, Wong B, Kecskemethy HH, Harcke HT. The relationship between fractures and DXA measures of BMD in the distal femur of children and adolescents with cerebral palsy or muscular dystrophy. J Bone Miner Res. 2010 Mar; 25(3):520-6.
Erin M. Miller, MS, CGC Genetic Counselor, Cardiology Clinic 513-636-4729 firstname.lastname@example.org
Genetic Counselor, Cardiology Clinic
University of Cincinnati
Cardiovascular genetic counseling; inherited arrhythmias; sudden cardiac arrest/sudden cardiac death; cardiomyopathy; aortopathy; Marfan syndrome; familial hypercholesterolemia
Erin Miller is a licensed genetic counselor in the Heart Institute at Cincinnati Children’s Hospital Medical Center. Her clinical activities are focused in the arena of cardiovascular genetics with specific interests in pediatric cardiomyopathy, arrhythmia and aortopathy. Research interests include the impact of clinical genetic testing and cardiac screening recommendations on family members, genotype-phenotype correlations, and the integration of cardiovascular genetic counseling and evaluation into clinical cardiology care. She is currently serving as the lead genetic counselor for the NIH/NHLBI funded study lead by Dr. Steven Lipshultz, ‘Genotype-phenotype correlations in pediatric cardiomyopathy’. Erin also has an interest in training and education and serves as a clinical supervisor and research advisory committee chair for the University of Cincinnati Genetic Counseling Graduate Program. She is a member of the National Society of Genetic Counselors and Cardiovascular Special Interest Group.
BS: Psychology, The University of Arizona, Tucson, AZ, 2003.
MSc: Medical Genetics, Indiana Univeristy, Indianapolis, IN, 2005.
Board Certification: American Board of Genetic Counseling, 2007.
Campbell M, Czosek RJ, Hinton RB, Miller EM. Exon 3 Deletion of Ryanodine Receptor Causes Left Ventricular Noncompaction, Worsening Catecholaminergic Polymorphic Ventricular Tachycardia, and Sudden Cardiac Arrest. American Journal of Medical Genetics. 2015;167A:2197-2200.
Boczek NJ, Miller EM, Ye D, Nesterenko V, Tester DJ, Antzelevitch C, Czosek RJ, Ware SM, Ackerman MJ. Novel Timothy Syndrome Mutation Leading to Increase in CACNA1C Window Current. Heart Rhythm. 2015;12:211-219.
Parrott A, James J, Goldenberg P, Hinton RB, Miller EM, Shikany A, Aylsworth AS, Kaiser-Rogers K, Ferns SJ, Lalani SR, Ware SM. Aortopathy in the 7q11.23 microduplication syndrome. American Journal of Medical Genetics. 2015;167(2):363-70.
Somers AE, Ware SM, Collins K, Jefferies JL, He H, Miller EM. Provision of cardiovascular genetic counseling services: current practice and future directions. J Genet Counsel. 2014;23(6):976-83.
Connor J, Hinton RB, Miller EM, Sund K, Ruschman JG, Ware SM. Chromosomal imbalances identified by microarray in infants with congenital heart defects. Congenit. Heart Dis. 2014;9(2):158-67.
Miller EM, Ware SM. Genetic Counseling for Hypertrophic and Dilated Cardiomyopathy: Uptake of genetic testing and cardiac screening among family members. J Genet Couns. 2013;22:258-267.
Kindel SJ, Miller EM, Gupta M, Cripe LH, Hinton RB, Spicer RL, Towbin JA, Ware SM. Pediatric cardiomyopathy: importance of genetic and metabolic evaluation. J Card Fail. 2012 May;18(5):396-403.
Czosek RJ, Miller EM, Goldenberg P, Towbin JA, Ware SM. Cardiac Electrical System Involvement in Alstrom Syndrome: Uncommon Causes of Dilated Cardiomyopathies. Cardiogenetics. 2012;2:(e2)1-10.
Miller E, Hopkin R, Bao L, Ware SM. Implications for genotype-phenotype predictions in Townes Brocks Syndrome: a case report of a novel SALL1 deletion and a review of the literature. Am J Med Genet A. 2012 Mar;158A(3):533-40.
Ashley S. Parrott, MS
Genetic Counselor II, Heart Institute 513-803-3318 email@example.com
Amy R. Shikany, MS, LGC
Genetic Counselor III, Heart Institute 513-803-3317 firstname.lastname@example.org
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