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Medical Director

Beth E. Haberman, MD
Medical Director, Newborn Intensive Care Unit (NICU)

513-636-5465

beth.haberman@cchmc.org

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Beth E. Haberman, MD

Medical Director, Newborn Intensive Care Unit (NICU)

Medical Director, Neonatal Transport Program

Associate Director, High-Risk Infant Follow-Up Program

Assistant Professor, UC Department of Pediatrics

Phone: 513-636-5465

Fax: 513-636-5846

Email: beth.haberman@cchmc.org

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Specialties

CDH and infant follow-up; care of infants with congenital diaphragmatic hernia; follow-up care of premature and term infants with complex medical needs

Education and Training

Fellowship: Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, 1996-1999.

Residency: Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 1993-1996.

MD: University of Louisville, Louisville, KY, 1993.

Publications

View PubMed Publications

Vuletin JF, Lim FY, Cnota J, Kline-Fath B, Salisbury S, Haberman B, Kingma P, Frischer J, Crombleholme T. Prenatal pulmonary hypertension index: novel prenatal predictor of severe postnatal pulmonary artery hypertension in antenatally diagnosed congenital diaphragmatic hernia. J Pediatr Surg. 2010 Apr;45(4):703-8.

Greenberg JM, Donovan EF, Warner BB, Haberman BE, Narendran V, Schibler KR. Neonatal Morbidities of Prenatal and Perinatal Origin. Creasy and Resnik”s Maternal-Fetal Medicine: Principles and Practice. 2008 6th ed. Chapter 58. Elsevier Ltd., Philadelphia, PA.

Castro L, Yolton K, Haberman B, Roberto N, Hansen NI, Ambalavanan N, Vohr BR, Donovan EF. Bias in reported neurodevelopmental outcomes among extremely low birth weight survivors. Pediatrics. 2004 Aug;114(2):404-10.

Faculty / Staff Physicians

Laurel B. Bookman, MD

513-803-1607

laurel.bookman@cchmc.org

Tanya E. Cahill, MD
Director, High-Risk Clinic

513-636-9057

tanya.cahill@cchmc.org

Michael W. Crossman, MD, PhD
Attending Neonatologist

859-301-3850

michael.crossman@cchmc.org

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Michael W. Crossman, MD, PhD

Attending Neonatologist

Assistant Professor, UC Department of Pediatrics

Phone: 859-301-3850

Fax: 859-301-2066

Email: michael.crossman@cchmc.org

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Specialties

Intestinal function and host-microbial interactions; bioethics and neonatal palliative care

Education and Training

PhD: Biochemistry, St. Louis University, St. Louis Mo., 1985.

MD: St. Louis University, St. Louis, Mo., 1986.

Residency: Pediatrics, Children's Hospital Medical Center, Cincinnati, Ohio, 1986-1989; Chief resident, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, 1989-1990.

Fellowship: Neonatal- Perinatal Medical Fellowship, Washington University School of Medicine, 1990-1993.

Certification: Neonatal-Perinatal Medicine, 1995, 2003.

Publications

View PubMed Publications

Crossman MW. For Whom the Bells Toll… J Pediatrics. 2007;151(1):4-5.

Mishra A, Hogan SP, Brandt EB, Wagner N, Crossman MW, Foster PS, Rothenberg ME. Enterocyte expression of the eotaxin and interleukin-5 transgenes induces compartmentalized dysregulation of eosinophil trafficking. J Biol Chem. 2002 Feb 8;277(6):4406-12.

Arrese M, Trauner M, Sacchiero RJ, Crossman MW, Scheider BL. Neither Intestinal Sequestration of Bile Acids nor Common Bile Duct Ligation Modulate the Expression and Function of the Rat Ileal Bile Acid Transporter. Hepatology. 1998;28:1081-1087.

Shneider BL, Setchell KDR, Crossman MW. Fetal and Neonatal Expression of the Apical Sodium-Dependent Bile Acid Transporter in the Rat Ileum and Kidney.Pediatric Research. 1997;42:189-194.

James M. Greenberg, MD
Co-Director, Perinatal Institute

513-636-3149

james.greenberg@cchmc.org

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James M. Greenberg, MD

Co-Director, Perinatal Institute

Director, Division of Neonatology

Professor, UC Department of Pediatrics

Phone: 513-636-3149

Fax: 513-803-0968

Email: james.greenberg@cchmc.org

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Specialties

Neonatal chronic lung disease; late preterm infant

Education and Training

MD: University of Illinois College of Medicine, Chicago, Ill., 1977-1981.

Pediatric Internship and Residency: University of Minnesota Hospital and Clinic, Minneapolis, Minn., 1981-1984. Chief Resident, Department of Pediatrics, University of Minnesota Hospital and Clinic, Minneapolis, Minn., 1984.

Fellowship: Immunology / Neonatology, University of Minnesota Hospital and Clinic, Minneapolis, Minn., 1985-1987; 1988-1989; visiting scientist, Medical Research Council Laboratory of Molecular Biology, Division of Protein and Nucleic Acid Chemistry, Cambridge, England.

Certification: American Board of Pediatrics, 1988; subspecialty board, Neonatal / Perinatal Medicine, 1989.

Publications

View PubMed Publications

Binder S, Hill K, Meinzen-Derr J, Greenberg JM, Narendran V. Increasing VLBW Deliveries at Subspecialty Perinatal Centers via Perinatal Outreach. Pediatrics. 2011 Mar;127(3):487-93.

Kulkarni RM, Herman A, Ikegami M, Greenberg JM, Akeson AL. Lymphatic ontogeny and effect of hypoplasia in developing lung. Mech Dev. 2011 Jan-Feb;128(1-2):29-40.

Kulkarni RM, Greenberg JM, Akeson AL. NFATc1 regulates lymphatic endothelial development. Mech Dev. 2009 May-Jun;126(5-6):350-65.

Mallory BP, Mead TJ, Wiginton DA, Kulkarni RM, Greenberg JM, Akeson AL. Lymphangiogenesis in the developing lung promoted by VEGF-A. Microvasc Res. 2006 Jul-Sep;72(1-2):62-73.

Preciado DA, Rutter MJ, Greenberg JM, Bahado-Singh R, Lambers D, Willging JP. Intrapartum management of severe fetal airway obstruction. J Otolaryngol. 2004 Oct;33(5):283-8.

Akeson AL, Cameron JE, Le Cras TD, Whitsett JA, Greenberg JM. Vascular endothelial growth factor-A induces prenatal neovascularization and alters bronchial development in mice. Pediatr Res. 2005 Jan;57(1):82-8.

Greenberg JM, Thompson FY, Brooks SK, Shannon JM, Akeson AL. Slit and robo expression in the developing mouse lung. Dev Dyn. 2004 Jun;230(2):350-60.

Le Cras TD, Spitzmiller RE, Albertine KH, Greenberg JM, Whitsett JA, Akeson AL. VEGF causes pulmonary hemorrhage, hemosiderosis, and air space enlargement in neonatal mice. Am J Physiol Lung Cell Mol Physiol. 2004 Jul;287(1):L134-42.

Akeson AL, Greenberg JM, Cameron JE, Thompson FY, Brooks SK, Wiginton D, Whitsett JA. Temporal and spatial regulation of VEGF-A controls vascular patterning in the embryonic lung. Dev Biol. 2003 Dec 15;264(2):443-55.

Greenberg JM, Thompson FY, Brooks SK, Shannon JM, McCormick-Shannon K, Cameron JE, Mallory BP, Akeson AL. Mesenchymal expression of vascular endothelial growth factors D and A defines vascular patterning in developing lung. Dev Dyn. 2002 Jun;224(2):144-53.

Paul S. Kingma, MD, PhD
Neonatal Director, Fetal Care Center of Cincinnati

513-636-2995

paul.kingma@cchmc.org

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Paul S. Kingma, MD, PhD

Neonatal Director, Fetal Care Center of Cincinnati

Assistant Professor, UC Department of Pediatrics

Phone: 513-636-2995

Fax: 513-636-7868

Email: paul.kingma@cchmc.org

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Specialties

Clinical Interests

Neonatology; congenital diaphragmatic hernia; neonatal infection

Research Interests

Innate immune systems; surfactant protein D; neutrophil function in Cystic Fibrosis

Education and Training

Fellowship: Cincinnati Children's Hospital Medical Center, 2005.

Residency: Cincinnati Children's Hospital Medical Center, 2003.

PhD: Vanderbilt University, TN, 2000.

MD: Vanderbilt University, TN, 2000.

BS: Calvin College, MI, 1992.

Publications

View PubMed Publications

King BA, Boyd JT, Kingma PS. Pulmonary maturational arrest and death in a patient with pulmonary interstitial glycogenosis. Pediatr Pulmonol. 2011 May 26.

Lee TC, Lim FY, Keswani SG, Frischer JS, Haberman B, Kingma PS, Habli M, Jaekle RK, Sharp G, Kline-Fath B, Rubio EI, Calvo M, Guimaraes C, Crombleholme TM. Late gestation fetal magnetic resonance imaging-derived total lung volume predicts postnatal survival and need for extracorporeal membrane oxygenation support in isolated congenital diaphragmatic hernia. J Pediatr Surg. 2011 Jun;46(6):1165-71.

King BA, Kingma PS. Surfactant Protein D Deficiency Increases Lung Injury during Endotoxemia. Am J Respir Cell Mol Biol. 2011 May;44(5):709-15.

Vuletin JF, Lim FY, Cnota J, Kline-Fath B, Salisbury S, Haberman B, Kingma P, Frischer J, Crombleholme T. Prenatal pulmonary hypertension index: novel prenatal predictor of severe postnatal pulmonary artery hypertension in antenatally diagnosed congenital diaphragmatic hernia. J Pediatr Surg. 2010 Apr;45(4):703-8.

White M, Kingma PS, Tecle T, Kacak N, Linders B, Heuser J, Crouch E, Hartshorn K. Multimerization of surfactant protein D, but not its collagen domain, is required for antiviral or opsonic activities related to influenza A virus. J Immunol. 2008 Dec 1;181(11):7936-43.

Kingma PS, Zhang L, Ikegami M, Hartshorn K, McCormack FX, Whitsett JA. Correction of pulmonary abnormalities in Sftpd-/- mice requires the collagenous domain of surfactant protein D. J Biol Chem. 2006 Aug 25;281(34):24496-505.

Kingma PS, Whitsett JA. In defense of the lung: surfactant protein A and surfactant protein D. Curr Opin Pharmacol. 2006 Jun;6(3):277-83.

Grants

Surfactant protein D in Systemic Infection and Inflammation. Principal Investigator. National Heart, Lung, and Blood Institute. Jul 2008 - Jun 2013.

Kristin R. Melton, MD
Neonatologist

513-803-0022

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Kristin R. Melton, MD

Neonatologist

Associate Professor, UC Department of Pediatrics

Phone: 513-803-0022

Fax: 513-636-7868

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Specialties

Clinical Interests

Congenital malformations

Research Interests

Craniofacial malformations; somitogenesis

Visit the Melton Lab.

Biography

Craniofacial defects are an important cause of morbidity for children worldwide, with craniofacial defects making up one third of all congenital anomalies and occurring in association with over 100 different genetic syndromes. Cranial neural crest cells are multipotent, migratory cells that form most of the bone, cartilage, connective tissue and peripheral nervous system of the head and face. Craniofacial defects are largely attributed to abnormalities in the formation, migration or differentiation of the neural crest. The cranial neural crest is responsive to the tissues that surround it, however, so craniofacial defects may result from a primary defect in neural crest cells, or from a defect in the tissues that signal to neural crest.

Kristin Melton, MD, has an interest in studying the tissues that signal to the neural crest, such as the endothelium and cranial mesoderm, and the signaling pathways utilized by these tissues. Using embryo culture techniques, cell culture and transgenic mouse models, Dr. Melton is investigating the interaction between the endothelium and the neural crest. Microarray has also been used to identify a number of mesoderm-specific genes that may play key roles in craniofacial development.

Dr. Melton is a practicing neonatologist and attends at the RCNIC in Cincinnati Children’s Hospital. Her clinical interests include newborns with complex congenital anomalies and genetic defects, as well as a focus on family-centered care.

Education and Training

Fellowship: Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, 2001.

Residency: Children's Mercy Hospital, Kansas City, Missouri, 1998.

MD: University of Nebraska, Omaha, Nebraska, 1995.

BA: Washington University, St. Louis, Missouri, 1991.

Publications

View PubMed Publications

Gibb S, Zagorska A, Melton K, Tenin G, Vacca I, Trainor P, Maroto M, Dale JK. Interfering with Wnt signalling alters the periodicity of the segmentation clock. Dev Biol. 2009 Jun 1;330(1):21-31.

Nesslein LL, Melton KR, Ikegami M, Na CL, Wert SE, Rice WR, Whitsett JA, Weaver TE. Partial SP-B deficiency perturbs lung function and causes air space abnormalities.Am J Physiol Lung Cell Mol Physiol. 2005 Jun;288(6):L1154-61.

Melton KR, Nesslein LL, Ikegami M, Tichelaar JW, Clark JC, Whitsett JA, Weaver TE. SP-B deficiency causes respiratory failure in adult mice.Am J Physiol Lung Cell Mol Physiol. 2003 Sep;285(3):L543-9.

Melton K, Akinbi HT. Neonatal jaundice. Strategies to reduce bilirubin-induced complications. Postgrad Med. 1999 Nov;106(6):167-8, 171-4, 177-8.

Stephanie L. Merhar, MD, MS

513-803-5180

stephanie.merhar@cchmc.org

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Stephanie L. Merhar, MD, MS

Assistant Professor, UC Department of Pediatrics

Phone: 513-803-5180

Email: stephanie.merhar@cchmc.org

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Education and Training

MD: University of Pennsylvania, Philadelphia, PA ,2005.

Residency: Pediatrics, Cincinnati Children's Hospital Medical Center, 2005-2008.

Fellowship: Neonatology, Cincinnati Children's Hospital Medical Center, 2008-2011.

Certification: Pediatrics, 2008.

Publications

View PubMed Publications

Merhar S. Biomarkers in neonatal posthemorrhagic hydrocephalus. Neonatology. 2011 Jul;101(1):1-7.

Merhar SL, Schibler KR, Sherwin CM, Meinzen-Derr J, Shi J, Balmakund T, Vinks AA. Pharmacokinetics of levetiracetam in neonates with seizures. J Pediatrics. 2011 Jul;159(1):152-154.

Merhar SL, Manning-Courtney P. Two boys with 47 XXY and autism. J Autism Devl Disord. 2007 May;37(5):840-6.

Merhar SL, Gilbert DL. Clinical (video) findings and cerebrospinal fluid neurotransmitters in 2 children with severe chronic bilirubin encephalopathy, including a former preterm infant without marked hyperbilirubinemia. Pediatrics. 2005 Nov;116(5):1226-30.

Levy SE, Mandell DS, Merhar SL, Ittenbach RF, Pinto-Martin JA. Use of complementary and alternative medicine among children recently diagnosed with autistic spectrum disorder. J Dev Behav Ped. 2003 Dec;24(6):418-423.

Danna M. Premer, MD
Staff Physician, Neonatology, Pulmonary Biology

513-636-4830

danna.premer@cchmc.org

Ward R. Rice, MD, PhD
Director, Neonatology Fellowship Training Program

513-636-3149

ward.rice@cchmc.org

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Ward R. Rice, MD, PhD

Director, Neonatology Fellowship Training Program

Director, Newborn Services, St. Elizabeth Medical Center

Professor, UC Department of Pediatrics

Phone: 513-636-3149

Fax: 513-636-7868

Email: ward.rice@cchmc.org

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Specialties

Clinical Interests

Hypotension in ELBW infants; EMR

Research Interests

Processing of Surfactant Protein C

Biography

Ward R. Rice, MD, PhD, is the Director of the Neonatology Fellowship Training Program and Director of Newborn Services, St. Elizabeth Medical Center.

Dr. Rice received MD and PhD degrees from the University of Chicago and has been on the faculty since 1983. He has been the Director of the Neonatology Fellowship Training Program since 1990. During this time, he has supervised the clinical training of more than 100 fellows who currently hold academic appointments across the United States and around the world.

His past NIH supported research accomplishments included identification of novel G-protein coupled receptors on alveolar type II cells and studies of the interaction of the opportunistic pathogen P carinii with alveolar type II cells. He currently works in collaboration with Dr. Timothy Weaver to study biosynthesis of Surfactant Protein C.

Education and Training

PhD: 1972-76 University of Chicago, Chicago, Illinois.

PhD: Biochemistry, Thesis Advisor: T.L. Steck, MD, Thesis: "Pyruvate Flux Across The Isolated Human Erythrocyte Membrane"

MD: 1972-78 University of Chicago, Chicago, Illinois.

Internship: 1978-79 Duke University Medical Center, Durham, North Carolina.

Residency: 1979-81 Duke University Medical Center, Durham, North Carolina.

Fellowship Neonatology: 1981-83 University of Cincinnati College of Medicine, Children's Hospital Medical Center.

Certification: Pediatrics, 1983; Sub-board Neonatal-Perinatal Medicine, 1983.

Publications

View PubMed Publications

Conkright JJ, Apsley KS, Martin EP, Ridsdale R, Rice WR, Na CL, Yang B, Weaver TE. Nedd4-2-mediated ubiquitination facilitates processing of surfactant protein-C. Am J Respir Cell Mol Biol. 2010 Feb;42(2):181-9.

Nesslein LL, Melton KR, Ikegami M, Na CL, Wert SE, Rice WR, Whitsett JA, Weaver TE. Partial SP-B deficiency perturbs lung function and causes air space abnormalities. Am J Physiol Lung Cell Mol Physiol. 2005 Jun;288(6):L1154-61.

Rice WR, Conkright JJ, Na CL, Ikegami M, Shannon JM, Weaver TE. Maintenance of the mouse type II cell phenotype in vitro. Am J Physiol Lung Cell Mol Physiol. 2002 Aug;283(2):L256-64.

Huffman Reed JA, Rice WR, Zsengellér ZK, Wert SE, Dranoff G, Whitsett JA. GM-CSF enhances lung growth and causes alveolar type II epithelial cell hyperplasia in transgenic mice. Am J Physiol. 1997 Oct;273(4 Pt 1):L715-25.

Rice W, Shannon JM, Burton F, Fiedeldey D. Expression of a brain-type cannabinoid receptor (CB1) in alveolar Type II cells in the lung: regulation by hydrocortisone. Eur J Pharmacol. 1997 May 30;327(2-3):227-32.

Linke MJ, Burton FM, Fiedeldey DT, Rice WR. Surfactant phospholipid secretion from rat alveolar type II cells: possible role of PKC isozymes. Am J Physiol. 1997 Feb;272(2 Pt 1):L171-7.

Chroneos ZC, Abdolrasulnia R, Whitsett JA, Rice WR, Shepherd VL. Purification of a cell-surface receptor for surfactant protein A. J Biol Chem. 1996 Jul 5;271(27):16375-83.

Haas M, Rice WR. Respiratory distress syndrome for the practicing pediatrician. Pediatr Ann. 1995 Nov;24(11):572-6, 579-80. Review.

Rice WR, Burton FM, Fiedeldey DT. Cloning and expression of the alveolar type II cell P2u-purinergic receptor. Am J Respir Cell Mol Biol. 1995 Jan;12(1):27-32.

Rice WR, Singleton FM, Linke MJ, Walzer PD. Regulation of surfactant phosphatidylcholine secretion from alveolar type II cells during Pneumocystis carinii pneumonia in the rat. J Clin Invest. 1993 Dec;92(6):2778-82.

Andrew Patrick South, MD, MPH

513-803-0998

andrew.south@cchmc.org

High Res

Andrew Patrick South, MD, MPH

Assistant Professor, UC Department of Pediatrics

Phone: 513-803-0998

Fax: 513-803-0968

Email: andrew.south@cchmc.org

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Specialties

Epidemiology and prevention of late-preterm birth; long term outcome of infants born with gastroschisis

Education and Training

MD: Case Western Reserve University, Cleveland, OH, 2000.

Residency: Pediatrics, University of North Carolina Children’s Hospital, Chapel Hill, NC.

Fellowship: Neonatology, University of North Carolina Children’s Hospital, Chapel Hill, NC.

Certification: Pediatrics, 2004; Neonatology, 2008.

Publications

View PubMed Publications

Slaughter JL, Pakrashi T, Jones DE, South AP, Shah TA. Echocardiographic detection of pulmonary hypertension in extremely low birth weight infants with bronchopulmonary dysplasia requiring prolonged positive pressure ventilation. J Perinatol. 2011 Feb 10.

South AP, Wessel JJ, Sberna A, Patel M, Morrow AL. Hospital readmission among infants with gastroschisis. J Perinatol. 2011 Feb 10.

South AP, Jones DE, Hall ES, Huo S, Meinzen-Derr J, Liu L, Greenberg JM. Spatial Analysis of Preterm Birth Demonstrates Opportunities for Targeted Intervention. Matern Child Health J. 2011 Feb 3.

Winik BC, Asial RA, McGrath JA, South AP, Boente MC. Acantholytic ectodermal dysplasia: clinicopathological study of a new desmosomal disorder. Br J Dermatol. 2009 Apr;160(4):868-74.

South AP, Marshall DD, Bose CL, Laughon MM. Growth and neurodevelopment at 16 to 24 months of age for infants born with gastroschisis. J Perinatol. 2008 Oct;28(10):702-6.

South MMT, Strauss RA, South AP, Boggess JF, Thorp JM. The use of non-nutritive sucking to decrease the physiologic pain response during neonatal circumcision: A randomized controlled trial. Am J of Obstet and Gynec 2005;193:537-43.

Grischkan J, Storfer-Isser A, Rosen CL, Larkin EK, Kirchner HL, South A, Wilson-Costello DC, Martin RJ, Redline S. Variation in childhood asthma among former preterm infants. J Pediatr 2004;144:321-6.