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Medical director

William D. Hardie, MD
Director, Pulmonary Function Laboratory

513-636-6771

william.hardie@cchmc.org

High Res

William D. Hardie, MD

Director, Pulmonary Function Laboratory

Professor, UC Department of Pediatrics

Phone: 513-636-6771

Fax: 513-636-4615

Email: william.hardie@cchmc.org

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Specialties

Visit the Hardie Lab.

Clinical Interests

Pulmonary function tests; pneumonia; empyema

Research Interests

Growth factors in lung remodeling

Education and Training

MD: Vanderbilt University, Nashville, Tenn., 1990.

Residency: Children's Hospital Medical Center, Cincinnati, Ohio.

Fellowship: Children's Hospital Medical Center, Cincinnati, Ohio.

Certification: Pediatrics, 1993; Pulmonary Medicine, 1999.

Publications

View PubMed Publications

Le Cras TD, Korfhagen TR, Davidson C, Schmidt S, Fenchel M, Ikegami M, Whitsett JA, Hardie WD. Inhibition of PI3K by PX-866 prevents transforming growth factor-alpha-induced pulmonary fibrosis. Am J Pathol. 2010 Feb;176(2):679-86

Deshmukh HS, McLachlan A, Atkinson JJ, Hardie WD, Korfhagen TR, Dietsch M, Liu Y, Di PY, Wesselkamper SC, Borchers MT, Leikauf GD. Matrix metalloproteinase-14 mediates a phenotypic shift in the airways to increase mucin production. Am J Respir Crit Care Med. 2009 Nov 1;180(9):834-45.

Hardie WD, Glasser SW, Hagood JS. Emerging concepts in the pathogenesis of lung fibrosis. Am J Pathol. 2009 Jul;175(1):3-16.

Korfhagen TR, Le Cras TD, Davidson CR, Schmidt SM, Ikegami M, Whitsett JA, Hardie WD. Rapamycin prevents transforming growth factor-alpha-induced pulmonary fibrosis. Am J Respir Cell Mol Biol. 2009 Nov;41(5):562-72.

Kramer EL, Mushaben EM, Pastura PA, Acciani TH, Deutsch GH, Khurana Hershey GK, Korfhagen TR, Hardie WD, Whitsett JA, Le Cras TD. Early growth response-1 suppresses epidermal growth factor receptor-mediated airway hyperresponsiveness and lung remodeling in mice. Am J Respir Cell Mol Biol. 2009 Oct;41(4):415-25.

Hardie WD. 50 Years Ago in The Journal of Pediatrics Pediatric Empyema: A Second Look at its Incidence and Importance. Kiesewetter, WB, Rusnock JR, Girdany BR. J Pediatr 1959;54:81-6. J Pediatr. 2009 Jan 1;154(1):131.

Loeb JS, Blower WC, Feldstein JF, Koch BA, Munlin AL, Hardie WD. Acceptability and repeatability of spirometry in children using updated ATS/ERS criteria. Pediatr Pulmonol. 2008 Oct;43(10):1020-4.

Hardie WD, Davidson C, Ikegami M, Leikauf GD, Le Cras TD, Prestridge A, Whitsett JA, Korfhagen TR. EGF receptor tyrosine kinase inhibitors diminish transforming growth factor-alpha-induced pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol. 2008 Jun;294(6):L1217-25.

Deshmukh HS, Shaver C, Case LM, Dietsch M, Wesselkamper SC, Hardie WD, Korfhagen TR, Corradi M, Nadel JA, Borchers MT, Leikauf GD. Acrolein-activated matrix metalloproteinase 9 contributes to persistent mucin production. Am J Respir Cell Mol Biol. 2008 Apr;38(4):446-54.

McPhail GL, Hardie WD. Cavitary lung lesions in a 2-year-old child. Respiration. 2008;76(1):117-8.

Grants

Functional Genomics of Chemical-Induced Acute Lung Injury. Co-Investigator. National Institute of Environmental Health Sciences. Sep 2006 - May 2011.

Epidermal Growth Factor Receptor Activation in Pulmonary Fibrosis. Principal Investigator. National Heart, Lung, and Blood Institute. Apr 2007 – Mar 2012.