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The Division of Pathology is home to specialists with a wide variety of backgrounds and areas of focus. As a team, this diversity makes us better prepared to care for your child’s unique needs. Learn more about our faculty.
David P. Witte, MD Director, Pathology
Director, Mass Spectrometry Laboratory
Professor, UC Department of Pathology & Laboratory Medicine
Molecular pathology; pediatric renal pathology
MD: University of Cincinnati, Cincinnati, Ohio, 1979.
Residency: Pediatrics, Washington University, St. Louis, Mo., 1979-1980; Pathology, Washington University, St. Louis, Mo., 1980-1984.
Fellowship: Pathology, Children's Hospital Medical Center, Cincinnati, Ohio, 1984-1986; Research Scholar, Pathology, Children's Hospital Medical Center, Cincinnati, Ohio, 1986-1989.
Certification: Anatomic Pathology, American Board of Pathology, 1985; Pediatric Pathology, American Board of Pathology, 1991.
Michael Baker, MD
Assistant Professor, UC Department of Pathology & Laboratory Medicine
Undergraduate: Louisiana State University, Baton Rouge, LA.
Medical School: Louisiana State University Medical Center, Baton Rouge, LA.
AP/CP Residency: Dartmouth Hitchcock Medical Center, Lebanon, NH.
Pediatric Pathology: Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
Certifications: Anatomic/Clinical/Pediatric Pathology.
Kevin E. Bove, MD
Professor, UC Department of Pediatrics
UC Department of Pathology & Laboratory Medicine
Dr. Bove's current research focus is on pathogenesis of biliary atresia and other cholestatic disorders of infancy. He has long term research interests in the early stages of childhood neoplasia and childhood diseases of skeletal muscle and heart.
Dr. Bove has been a career academic pediatric pathologist at Cincinnati Children's since 1968. He functions as a surgical pathologist, autopsy consultant and electron microscopist with diverse clinical interests. His collaborations with faculty and fellows in many divisions have resulted in more than 180 peer-reviewed and more than 120 publications.
Kevin E. Bove, MD, has 32 years experience as a pediatric pathologist at Cincinnati Children's Hospital Medical Center.
Dr. Bove has achieved national recognition as an expert in tumors; neuromuscular diseases; liver diseases of children and performance / interpretation of pediatric autopsies.
Dr. Bove has and continues to be involved in leadership positions in the Society for Pediatric Pathology and the College of American Pathologists.
MD: State University of New York, Buffalo, NY.
Residency: Rotating Intern, Cincinnati General Hospital, 1961-1962; Pathology, Cincinnati General Hospital, 1962-1966.
Certification: American Board of Pathology in Anatomic and Clinical Pathology, 1967 and 1968; Pediatric Pathology, 1990.
Margaret H. Collins, MD
Pediatric gastrointestinal pathology; eosinophilic gastrointestinal diseases; biopsy analyses; primary study endpoints; novel therapies to treat eosinophilic esophagitis in children; disorders of bowel immunity; bowel motility disorders
BS: Fordham University, NY, 1972.
MD: Georgetown University, Washington, D.C., 1977.
Residency: Pathology, New York Hospital, NY, 1977-80; Pathology, Columbia-Presbyterian Medical Center, NY, 1980-83.
Fellowship: Research, New York Lung Association, Columbia-Presbyterian Medical Center, N.Y., 1983-85; Research, American Lung Association, Columbia-Presbyterian Medical Center, NY, 1985-87.
Certification: Pathology, 1981; Pediatric Pathology, 1991.
Nikolaidis NM, Kulkarni RM, Gray JK, Collins MH, Waltz SE. Ron receptor deficient alveolar myeloid cells exacerbate LPS-induced acute lung injury in the murine lung. Innate Immun. 2010 Nov 18.
Sherrill JD, Gao PS, Stucke EM, Blanchard C, Collins MH, Putnam PE, Franciosi JP, Kushner JP, Abonia JP, Assa'ad AH, Kovacic MB, Biagini Myers JM, Bochner BS, He H, Hershey GK, Martin LJ, Rothenberg ME. Variants of thymic stromal lymphopoietin and its receptor associate with eosinophilic esophagitis. J Allergy Clin Immunol. 2010 Jul;126(1):160-5.e3.
DeBrosse CW, Collins MH, Buckmeier Butz BK, Allen CL, King EC, Assa'ad AH, Abonia JP, Putnam PE, Rothenberg ME, Franciosi JP. Identification, epidemiology, and chronicity of pediatric esophageal eosinophilia, 1982-1999. J Allergy Clin Immunol. 2010 Jul;126(1):112-9.
Abonia JP, Blanchard C, Butz BB, Rainey HF, Collins MH, Stringer K, Putnam PE, Rothenberg ME. Involvement of mast cells in eosinophilic esophagitis. J Allergy Clin Immunol. 2010 Jul;126(1):140-9.
Caldwell JM, Blanchard C, Collins MH, Putnam PE, Kaul A, Aceves SS, Bouska CA, Rothenberg ME. Glucocorticoid-regulated genes in eosinophilic esophagitis: a role for FKBP51. J Allergy Clin Immunol. 2010 Apr;125(4):879-888.e8.
Rothenberg ME, Spergel JM, Sherrill JD, Annaiah K, Martin LJ, Cianferoni A, Gober L, Kim C, Glessner J, Frackelton E, Thomas K, Blanchard C, Liacouras C, Verma R, Aceves S, Collins MH, Brown-Whitehorn T, Putnam PE, Franciosi JP, Chiavacci RM, Grant SF, Abonia JP, Sleiman PM, Hakonarson H. Common variants at 5q22 associate with pediatric eosinophilic esophagitis. Nat Genet. 2010 Apr;42(4):289-91.
Blanchard C, Stucke EM, Burwinkel K, Caldwell JM, Collins MH, Ahrens A, Buckmeier BK, Jameson SC, Greenberg A, Kaul A, Franciosi JP, Kushner JP, Martin LJ, Putnam PE, Abonia JP, Wells SI, Rothenberg ME. Coordinate interaction between IL-13 and epithelial differentiation cluster genes in eosinophilic esophagitis. J Immunol. 2010 Apr 1;184(7):4033-41.
Miller SJ, Lan ZD, Hardiman A, Wu J, Kordich JJ, Patmore DM, Hegde RS, Cripe TP, Cancelas JA, Collins MH, Ratner N. Inhibition of Eyes Absent Homolog 4 expression induces malignant peripheral nerve sheath tumor necrosis. Oncogene. 2010 Jan 21;29(3):368-79.
Vicario M, Blanchard C, Stringer KF, Collins MH, Mingler MK, Ahrens A, Putnam PE, Abonia JP, Santos J, Rothenberg ME. Local B cells and IgE production in the oesophageal mucosa in eosinophilic oesophagitis. Gut. 2010 Jan;59(1):12-20.
Prosperi JR, Becher KR, Willson TA, Collins MH, Witte DP, Goss KH. The APC tumor suppressor is required for epithelial integrity in the mouse mammary gland. J Cell Physiol. 2009 Aug;220(2):319-31.
Anita Gupta, MD
Assistant Professor, UC Department of Pediatrics
Pediatric pathology; surgical pathology; electron microscopy.
Liver tumors; cardiac transplants; vascular anomalies; cilia abnormalities.
Hammill AM, Wentzel M, Gupta A, Nelson S, Lucky A, Elluru R, Dasgupta R, Azizkhan RG, Adams DM. Sirolimus for the treatment of complicated vascular anomalies in children. Pediatr Blood Cancer. 2011 Dec 1;57 (6):1018-24
Maugans T, Sheridan RM, Adams D, Gupta A. Cutaneous vascular anomalies associated with neural tube defects: nomenclature and pathology revisited. Neurosurgery. 2011 Jul;69(1):112-8
Gupta A, Kozakewich H. Histopathology of vascular anomalies. Clin Plast Surg. 2011 Jan;38(1):31-44.
Bischoff A, Gupta A, D'Mello S, Mezoff A, Podberesky D, Barnett S, Keswani S, Frischer JS. Crohn's disease limited to the appendix: a case report in a pediatric patient. Pediatr Surg Int. 2010 Nov;26(11):1125-8.
Stevenson CB, Leach JL, Gupta A, Crone KR. Cystic degeneration of the cerebellar tonsils in pediatric patients with Chiari Type I malformation. J Neurosurg Pediatr. 2009 Dec;4(6):557-63.
Zynger DL, Gupta A, Luan C, Chou PM, Yang GY, Yang XJ. Expression of glypican 3 in hepatoblastoma: an immunohistochemical study of 65 cases. Hum Pathol. 2008; 39 (2):224-30.
Adley BP, Gupta A, Lin F, Luan C, Teh BT, Yang XJ. Expression of Kidney-Specific Cadherin in Chromophobe Renal Cell Carcinoma. Am J Clin Pathol. 2006 Jul; 126(1): 79-85.
Blecha MJ, Gupta A, Hoover JD, Madonna MB. Chronic abdominal pain secondary to a mucous cystadenoma of the appendix in a 10-year-old boy. J Pediatr Surg. 2005 Nov; 40(11): 1792-4.
Salanitri G, Huo E, Miller F, Gupta A, Pereles S. MRI of Mycotic Sinus of Valsalva Pseudoaneurysm Secondary to Aspergillus Pericarditis. Amer J Roentgenology. 2005; 184: S25-S27
Gupta A, Madallozo J, Win Htin T, Shah A, Chou PM. Spindle cell rhabdomyosarcoma of the tongue in an infant. Pathol Research and Practice. 2004; 200: 537-543.
Richard L. McMasters, MD Staff Pathologist
Dr. McMasters has a research interest in childhood leukemia, lymphoma and bone marrow failure syndromes. His current focus is on applications of flow cytometry in the diagnosis and management of these disorders.
Dr. McMasters joined Cincinnati Children's in 2008. His main clinical interests are hematopathology and general surgical pathology. He is the laboratory director at Cincinnati Children's Liberty Campus.
Lili Miles, MD Staff Pathologist
Director, Fellowship Training Program
Associate Professor, Division of Pediatric Pathology
Pediatric pathology; pediatric neuropathology; pediatric neuromuscular disease
Mitochondrial diseases; coenzyme Q10; pediatric brain tumors; classification and grading of cortical dysplasia; hepatic pathology in pediatric NASH patients and animal models
Seo JH, Holland K, Rose D, Rozhkov L, Fujiwara H, Byars A, Arthur T, DeGrauw T, Leach JL, Gelfand MJ, Miles L, Mangano FT, Horn P, Lee KH. Multimodality imaging in the surgical treatment of children with nonlesional epilepsy. Neurology. 2011 Jan 4;76(1):41-8.
Phillips CL, Miles L, Jones BV, Sutton M, Crone K, Fouladi M. Medulloblastoma with melanotic differentiation: case report and review of the literature. J Neurooncol. 2010 Oct 16.
Miles MV, Putnam PE, Miles L, Tang PH, DeGrauw AJ, Wong BL, Horn PS, Foote HL, Rothenberg ME. Acquired coenzyme Q10 deficiency in children with recurrent food intolerance and allergies. Mitochondrion. 2011 Jan;11(1):127-35.
Kohli R, Kirby M, Xanthakos SA, Softic S, Feldstein AE, Saxena V, Tang PH, Miles L, Miles MV, Balistreri WF, Woods SC, Seeley RJ. High-fructose, medium chain trans fat diet induces liver fibrosis and elevates plasma coenzyme Q9 in a novel murine model of obesity and nonalcoholic steatohepatitis. Hepatology. 2010 Sep;52(3):934-44.
McAuliffe JJ, Loepke AW, Miles L, Joseph B, Hughes E, Vorhees CV. Desflurane, isoflurane, and sevoflurane provide limited neuroprotection against neonatal hypoxia-ischemia in a delayed preconditioning paradigm. Anesthesiology. 2009 Sep;111(3):533-46.
Kurth CD, McCann JC, Wu J, Miles L, Loepke AW. Cerebral oxygen saturation-time threshold for hypoxic-ischemic injury in piglets. Anesth Analg. 2009 Apr;108(4):1268-77.
Loepke AW, Istaphanous GK, McAuliffe JJ 3rd, Miles L, Hughes EA, McCann JC, Harlow KE, Kurth CD, Williams MT, Vorhees CV, Danzer SC. The effects of neonatal isoflurane exposure in mice on brain cell viability, adult behavior, learning, and memory. Anesth Analg. 2009 Jan;108(1):90-104.
Miles L, DeGrauw TJ, Dinopoulos A, Cecil KM, van der Knaap MS, Bove KE. Megalencephalic leukoencephalopathy with subcortical cysts: a third confirmed case with literature review. Pediatr Dev Pathol. 2009 May-Jun;12(3):180-6.
Miles MV, Tang PH, Miles L, Steele PE, Moye MJ, Horn PS. Validation and application of an HPLC-EC method for analysis of coenzyme Q10 in blood platelets. Biomed Chromatogr. 2008 Dec;22(12):1403-8.
Miles MV, Miles L, Tang PH, Horn PS, Steele PE, DeGrauw AJ, Wong BL, Bove KE. Systematic evaluation of muscle coenzyme Q10 content in children with mitochondrial respiratory chain enzyme deficiencies. Mitochondrion. 2008 Mar;8(2):170-80.
Joel E. Mortensen, PhD Director, Diagnostic Infectious Diseases Testing Laboratory (Microbiology and Virology)
Director, Diagnostic Infectious Diseases Testing Laboratory (Microbiology and Virology)
Associate Professor, UC Department of Pediatrics
Dr. Mortensen's current research focus is antimicrobial susceptibility testing of fastidious pediatric pathogens.
Dr. Mortensen is a career academic clinical microbiologist in the Department of Pathology and Laboratory Medicine at Cincinnati Children's since 1991. Beyond providing consultation to the medical staff in Clinical Microbiology, his clinical interests include the application of rapid testing methods into the clinical microbiology laboratory and outpatient settings and LEAN manufacturing processes applied to Clinical Microbiology. His collaborations with faculty and fellows have resulted in more than 100 peer-reviewed publications, case studies and text chapters.
Motley WW, Melson AT, Mortensen JE. Pediatric Metarhizium anisopliae keratitis. J AAPOS. 2011 Feb 10.
Major TA, Panmanee W, Mortensen JE, Gray LD, Hoglen N, Hassett DJ. Sodium nitrite-mediated killing of the major cystic fibrosis pathogens Pseudomonas aeruginosa, Staphylococcus aureus, and Burkholderia cepacia under anaerobic planktonic and biofilm conditions. Antimicrob Agents Chemother. 2010 Nov;54(11):4671-7.
Chhabra MS, Motley WW 3rd, Mortensen JE. Eikenella corrodens as a causative agent for neonatal conjunctivitis. J AAPOS. 2008 Oct;12(5):524-5.
Huppert JS, Mortensen JE, Reed JL, Kahn JA, Rich KD, Hobbs MM. Mycoplasma genitalium detected by transcription-mediated amplification is associated with Chlamydia trachomatis in adolescent women. Sex Transm Dis. 2008 Mar;35(3):250-4.
Huppert JS, Mortensen JE, Reed JL, Kahn JA, Rich KD, Miller WC, Hobbs MM. Rapid antigen testing compares favorably with transcription-mediated amplification assay for the detection of Trichomonas vaginalis in young women. Clin Infect Dis. 2007 Jul 15;45(2):194-8.
Huppert JS, Biro F, Lan D, Mortensen JE, Reed J, Slap GB. Urinary symptoms in adolescent females: STI or UTI? J Adolesc Health. 2007 May;40(5):418-24.
Iyer SB, Gerber MA, Pomerantz WJ, Mortensen JE, Ruddy RM. Effect of point-of-care influenza testing on management of febrile children. Acad Emerg Med. 2006 Dec;13(12):1259-68.
Huppert JS, Gerber MA, Deitch HR, Mortensen JE, Staat MA, Adams Hillard PJ. Vulvar ulcers in young females: a manifestation of aphthosis. J Pediatr Adolesc Gynecol. 2006 Jun;19(3):195-204.
Mortensen JE, Gerrety MJ, Gray LD. Surveillance of antimicrobial resistance in Neisseria meningitidis from patients in the Cincinnati Tri-State region (Ohio, Kentucky, and Indiana). J Clin Microbiol. 2006 Apr;44(4):1592-3.
Yoon SS, Coakley R, Lau GW, Lymar SV, Gaston B, Karabulut AC, Hennigan RF, Hwang SH, Buettner G, Schurr MJ, Mortensen JE, Burns JL, Speert D, Boucher RC, Hassett DJ. Anaerobic killing of mucoid Pseudomonas aeruginosa by acidified nitrite derivatives under cystic fibrosis airway conditions. J Clin Invest. 2006 Feb;116(2):436-46.
Lindsey E. Romick-Rosendale, PhD Director, Metabolomics Core Facility, Mass Spectrometry Laboratory, Division of Pathology and Laboratory Medicine
Director, Metabolomics Core Facility, Mass Spectrometry Laboratory, Division of Pathology and Laboratory Medicine
BS: Chemistry, Marietta College, Marietta, OH, 2007.
PhD: Chemistry with concentration in biological chemistry, Miami University, Oxford, OH, 2011.
Romick-Rosendale LE, Lui VWY, Grandis JR, Wells SI. The Fanconi anemia pathway: Repairing the link between DNA damage and squamous cell carcinoma. Mutat Res. 2013 Mar-Apr; 743-744:78-88.
Romick-Rosendale LE, Lagomarcino AJ, Patel NB, Taft D, Morrow AL, Kennedy MA. Prolonged antibiotic use induces intestinal injury in mice that is repaired after removing antibiotic pressure: Implications for empiric antibiotic therapy. Metabolomics. 2014 10;1:8-20.
Romick-Rosendale LE, Schibler KR, Kennedy MA. A potential biomarker for acute kidney injury in preterm infants from metabolic profiling. J Mol Biomark Diagn. 2012 S3:001.
Romick-Rosendale LE, Brunner HI, Bennett MR, Mina R, Nelson S, Petri M, Kiani A, Kiani A, Devarajan P, Kennedy MA. Identification of urinary metabolites that distinguish membranous lupus nephritis from proliferative lupus nephritis and focal segmental glomerulosclerosis. Arthritis Res Ther. 2011;13(6)R199.
Goodpaster AM, Romick-Rosendale LE, Kennedy MA. Statistical significance analysis of nuclear magnetic resonance-based metabonomics data. Anal Biochem. 2010 Jun 1;401(1):134-143.
Romick-Rosendale LE, Goodpaster AM, Hanwright PJ, Patel NB, Wheeler ET, Chona DL, Kennedy MA. NMR-based metabonomics analysis of mouse urine and fecal extracts following oral treatment with the broad-spectrum antibiotic enrofloxacin (Baytril). Magn Reson Chem. 2009 Dec;47 Suppl 1:S36-46.
Kenneth D. Setchell, PhD Director, Mass Spectrometry Lab
Director, Mass Spectrometry Lab
Kenneth D. Setchell, PhD, joined the tenured faculty of the Department of Pediatrics, University of Cincinnati College of Medicine in 1984, having moved from the Clinical Research Centre of the Medical Research Council, (UK) where he previously held a tenured Scientific position. In 1973 he obtained a PhD Degree in steroid biochemistry from the University of London. He was then awarded a Fellowship from The Royal Society for post-doctoral studies at the Karolinska Institute in Stockholm, Sweden (1974-1975) in the application of mass spectrometry to clinical and biomedical problems specifically relating to the steroid hormone field. He returned to the United Kingdom to a scientific position in the Division of Clinical Chemistry at the Medical Research Council's Clinical Research Centre where he continued his research in the field of steroids, expanding into cholesterol and bile acid metabolism as it related to gastrointestinal diseases. His parallel research discoveries of the first mammalian lignans later led to the discovery of soy isoflavones in humans, their association with soy intake, and established his research in the area of bioactive plant constituents and human nutrition and disease.
In September 1984, Dr. Setchell moved to Cincinnati to become Director of a new Clinical Mass Spectrometry facility at Cincinnati Children's Hospital Medical Center where he is now a tenured Professor in the Department of Pediatrics. His research program is internationally recognized as a leader in several areas of research that established collaborations with other groups from England, Italy, Germany, France Sweden, Canada and Australia. He has consulted with pharmaceutical and food companies, and to industries involved in clinical and biochemical research. Dr. Setchell cites >200 scientific publications and has presented over 250 papers at National and International symposia, while serving on National and International committees and Editorial Boards of International journals. Dr. Setchell was awarded the 1997 Gilbride award by the Canadian Liver Foundation for his contributions to the diagnosis and treatment of liver disease. He received awards from the AOCS at the 3rd International Symposium on the "Role of Soy in Preventing and Treating Chronic Disease" in 1999 for his outstanding contributions to increasing understanding and awareness of the health benefits of soy foods and soybean constituents, and from North American Menopause Society (NAMS) 2000 annual award for his research on soy and women's health. He received the Roche 2003 International Award for Innovative Research in Human Nutrition for his discoveries of classes of phytoestrogens and the 2004 Adolf Windaus Prize for research on bile acids and the discovery of genetic defects in the cholesterol-bile acid pathway causing liver disease.
Some of his most significant research contributions include the following:
Shiva K. Shanmukhappa, DVM, PhD, Diplomate ACVP
Liver repair and regeneration; NASH; metabolic complication of HIV; sickle cell disease; nephropathy.
Shiva Kumar Shanmukhappa joined the Cincinnati Children's Division of Pathology and Laboratory Medicine in 2012 as an assistant professor of pathology overseeing the research pathology core.
From 2009-2012, Dr. Shanmukhappa was a comparative pathology fellow Division of Comparative Pathology, New England Primate Research Center, Harvard Medical School.
Dr. Shanmukhappa was research fellow in Division of Gastroenterology, Hepatology and Nutrition from 2003 to 2009 where he primarily worked on understanding the molecular mechanism involved in liver repair and regeneration as well as the induction of pancreatic cells in liver during defective liver repair. He identified the role of plasmin in liver repair. He has shown that plasmin mediates liver repair through the activation of HGF-MET signaling mainly affecting cell motility.
Dr. Shanmukhappa has an active research career with his primary interests in molecular control of liver repair, regeneration, biliary atresia, NASH and metabolic complications of HIV.
DVM: Veterinary College, University of Agricultural Sciences, Bangalore, India,1996.
PhD: Department of Veterinary Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS, 2002.
Residency: Comparative Pathology, New England Primate Research Center, Harvard Medical School, Southborough, MA.
Certification: Veterinary Anatomic Pathology, 2013.
Bessho K, Shanmukhappa K, Sheridan R, Shivakumar P, Mourya R, Walters S, Kaimal V, Dilbone E, Jegga AG, Bezerra JA. Integrative genomics identifies candidate microRNAs for pathogenesis of experimental biliary atresia. BMC Syst Biol. 2013 Oct 20;7:104.
Marzioni M, Saccomanno S, Agostinelli L, Rychlicki C, De Minicis S, Pierantonelli I, Trauner M, Fickert P, Müller T, Shanmukhappa K, Trozzi L, Candelaresi C, Baroni GS, Benedetti A. PDX-1/Hes-1 interactions determine cholangiocyte proliferative response to injury in rodents: possible implications for sclerosing cholangitis. J Hepatol. 2013 Apr;58(4):750-6.
Sasseville VG, Mansfield KG, Mankowski JL, Tremblay C, Terio KA, Mätz-Rensing K, Gruber-Dujardin E, Delaney MA, Schmidt LD, Liu D, Markovits JE, Owston M, Harbison C, Shanmukhappa SK, Miller AD, Kaliyaperumal S, Assaf BT, Kattenhorn L, Macri SC, Simmons HA, Baldessari A, Sharma P, Courtney C, Bradley A, Cline JM, Reindel JF, Hutto DL, Montali RJ, Lowenstine LJ. Meeting report: Spontaneous lesions and diseases in wild, captive-bred, and zoo-housed nonhuman primates and in nonhuman primate species used in drug safety studies. Vet Pathol. 2012 Nov;49(6):1057-69.
Sheridan R, Lampe K, Shanmukhappa SK, Putnam P, Keddache M, Divanovic S, Bezerra J, Hoebe K. Lampe1: an ENU-germline mutation causing spontaneous hepatosteatosis identified through targeted exon-enrichment and next-generation sequencing. PLoS One. 2011;6(7):e21979.
Mann EA, Shanmukhappa K, Cohen MB. Lack of guanylate cyclase C results in increased mortality in mice following liver injury. BMC Gastroenterol. 2010 Aug 2;10:86.
Marzioni M, Saccomanno S, Candelaresi C, Rychlicki C, Agostinelli L, Shanmukhappa K, Trozzi, L, Pierantonelli I, De Minicis S, Benedetti A. Pancreatic Duodenal Homeobox-1 de novo expression drives cholangiocyte neuroendocrine-like transdifferentiation. J Hepatol. 2010 Oct;53(4):663-70.
Shanmukhappa K, Degen J, Bezerra J. Plasmin-mediated proteolysis is required for hepatocyte growth factor activation during liver repair. J Biol Chem. 2009 May 8;284(19): 12917-12923.
Shanmukhappa K, Kim JK and Kapil S. Role of CD151, A tetraspanin, in porcine reproductive and respiratory syndrome virus infection. Virol J. 2007; 4: 62.
Shanmukhappa K, Sabla GE, Degen JL, Bezerra JA. Urokinase-type plasminogen activator supports liver repair independent of its cellular receptor. BMC Gastroenterol. 2006 Nov 29;6:40.
Kim JK, Fahad AM, Shanmukhappa K, Kapil S. Defining the cellular target(s) of porcine reproductive and respiratory syndrome virus blocking monoclonal antibody 7G10. J Virol. 2006 Jan;80(2):689-96.
Amy T. Sheil, MD
Pediatric and perinatal autopsy; placental pathology; sudden unexpected infant death
MD: Creighton University School of Medicine, 2003.
Residency: AP/CP, Medical University of South Carolina, 2007.
Fellowship: Forensic Pathology, Medical University of South Carolina, 2007.
Fellowship: Pediatric Pathology, Cincinnati Children’s Hospital Medical Center, 2010.
Certification: Anatomic and Clinical Pathology, 2007; Forensic Pathology, 2008; Pediatric Pathology, 2011.
Cohen S, Woods RK, Sheil AT, et al. Myocardial infarction from pacing wire. Annals of Thoracic Surgery. 2013.
Ciecierega T, Almadhoun O, Sheil AT, et al. Congenital achalasia of the lower esophageal sphincter preceding eosinophilic esophagitis in three infants. Pediatric Surgery International. 2013.
Sheil AT, Collins KA. Fatal Birth Trauma Due to an Undiagnosed Abdominal Teratoma: Case Report and Comprehensive Review of the Literature. Am J For Med Path. 2007;28(2):121-127.
Sheil AT, Collins KA, Schandl CA, Harley RA. Fatal Neurotoxic Response to Neuroleptic Medications: Case Report and Review of the Literature. Am J For Med Path. 2007;28(2):116-120.
Ross SE, Sawhney R, Sheil AT, Chaudhary U. A Rare Case of Clear Cell Adenocarcinoma of the Bladder with Unique Pathological Features. Am J Med Sci. 2007;333(1): 63-65.
Rachel M. Sheridan, MD
Pediatric pathology; liver pathology
Jerzy W. Stanek, MD, PhD
MD: College of Medicine, Jagiellonian University, Kraków, Poland, 1968.PhD: College of Medicine, Jagiellonian University, Kraków, Poland, 1974Residencies: University Hospital of Obstetrics and Gynecology, Jagiellonian University, Kraków, Poland, 1970-1976; Georgetown University Medical Center, Washington, DC, and Rush Presbyterian-St.Luke's Medical Center, Chicago, IL, 1990-1994.
Fellowship: Reproductive Endocrinology, University Hospital of Obstetrics and Gynecology, Kraków, Poland; 1976-1977.
Certifications: Obstetrics and Gynecology, Polish Board of Obstetrics and Gynecology, 1976; Endocrinology, Postgraduate Medical Center, Poland, 1977; Anatomic and Clinical Pathology, American Board of Pathology, 1994; Pediatric Pathology, American Board of Pathology, 1999.
Stanek J. Periarterial stem villous edema is associated with hypercoiled umbilical cord and stem obliterative endarteritis. OJOG. 2013;3(9A):9-14.
Calvo-Garcia MA, Lim FY, Stanek J, Bitters C, Kline-Fath BM. Congenital peribronchial myofibroblastic tumor: Prenatal imaging clues to differentiate from other fetal chest lesions. Pediatr Radiol. 2013 Oct 31. Epub ahead of print.
Stanek J. Comparison of placental pathology in preterm, late-preterm, near-term, and term births. Am J Obstet Gynecol. 2013 Oct 18. Epub ahead of print
Stanek J, Biesiada J. Relation of placental diagnosis in stillbirth to fetal maceration and gestational age at delivery. J Perinat Med. 2013. In press.
Stanek J. Hypoxic patterns of placental injury: a review. Arch Pathol Lab Med. 2013 May;137(5):706-20.
Stanek J. Placental membrane laminar necrosis and chorionic microcysts. Pediatr Dev Pathol. 2012 Nov-Dec; 15(6):514-6.
Sheridan RM, Stanek J, Khoury J, Handwerger S. Abnormal expression of transcription factor AP-2α in pathologic placentas. Hum Pathol. 2012 Nov;43(11):1866-74.
Stanek J, Biesiada J. Clustering of maternal/fetal clinical conditions and outcomes and placental lesions. Am J Obstet Gynecol. 2012 Jun;206(6):493.e1-8.
Laor T, Stanek J, Leach JL. Diprosopus tetraophthalmus: CT as a complement to autopsy. Br J Radiol. 2012 Jan;85(1009):e10-3.
Sheridan RM, Michelfelder EC, Choe KA, Divanovic A, Liu C, Ware S, Stanek J. Ductus arteriosus aneurysm with massive thrombosis of pulmonary artery and fetal hydrops. Pediatr Dev Pathol. 2012 Jan-Feb;15(1):79-85.
Paul E. Steele, MD Medical Director, Clinical Laboratory
Medical Director, Clinical Laboratory
Paul E. Steele, MD, is medical director of the clinical laboratory at Cincinnati Children's Hospital Medical Center, arriving in 1999. He came to Children's Hospital Medical Center of Cincinnati from University Hospital of Cincinnati, where he was a member of the laboratory medicine staff for 11 years.
Dr. Steele's background includes general laboratory directorship, as he was Medical Director of University Hospital's Immediate Response Laboratory for over two years before coming to Cincinnati Children's.
Dr. Steele has also served as medical director of Diagnostic Immunology since arriving at University Hospital. In this position, he was involved in humoral immunology, including infectious disease serology, autoimmune testing, protein characterization, and allergy testing; he was also involved in flow cytometry, including transplantation, stem cell and HIV monitoring, as well as evaluation and monitoring of hematopoietic neoplasms.
Dr. Steele has also been involved in molecular pathology. At University Hospital, he put in place a molecular diagnostics laboratory which provided molecular genetic detection of lymphoid clonality as well as chromosomal translocation in chronic myelocytic leukemia. At Children's Hospital Medical Center of Cincinnati, he has become a participant in overseeing the molecular genetic testing for infectious disease.
Dr. Steele's research interests include the evaluation of human endogenous retroviral sequences and their role in human pathology. This work is an outgrowth of studies he began as a postdoctoral fellow at the National Institutes of Health.
Specifically, Dr. Steele has created antisera to a biosynthetic fusion protein containing a portion of a human endogenous retroviral envelope gene that encodes a putative immunosuppressive protein. This antisera detects a human protein which is the subject of Dr. Steele's study.
MD: University of Missouri, Kansas City, 1978.
Residency: Anatomic Pathology, Massachusetts General Hospital, Boston 1978-81; Clinical Pathology, Barnes Hospital, St. Louis, MO, 1984-86.
Fellowships: Basic science fellowship, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD, 1981-84.
Certification: Anatomic and Clinical Pathology, 1987.
Keith F. Stringer, MD Pathologist
BSc: University of British Columbia, Vancouver, British Columbia, Canada.
MSc: University of Toronto, Toronto, Ontario, Canada.
MD: University of Calgary, Calgary, Alberta, Canada, 1995.
DABP: Anatomic and Pediatric Pathology.
Xu YH, Jia L, Quinn B, Zamzow M, Stringer K, Aronow B, Sun Y, Zhang W, Setchell KD, Grabowski GA. Global gene expression profile progression in Gaucher disease mouse models. BMC Genomics. 2011 Jan 11;12:20. Sivaprasad U, Askew DJ, Ericksen MB, Gibson AM, Stier MT, Brandt EB, Bass SA, Daines MO, Chakir J, Stringer KF, Wert SE, Whitsett JA, Le Cras TD, Wills-Karp M, Silverman GA, Khurana Hershey GK. A nonredundant role for mouse Serpinb3a in the induction of mucus production in asthma. J Allergy Clin Immunol. 2011 Jan;127(1):254-61, 261.e1-6. Shi Z, Dragin N, Miller ML, Stringer KF, Johansson E, Chen J, Uno S, Gonzalez FJ, Rubio CA, Nebert DW. Oral benzo[a]pyrene-induced cancer: two distinct types in different target organs depend on the mouse Cyp1 genotype. Int J Cancer. 2010 Nov 15;127(10):2334-50.
Abonia JP, Blanchard C, Butz BB, Rainey HF, Collins MH, Stringer K, Putnam PE, Rothenberg ME. Involvement of mast cells in eosinophilic esophagitis. J Allergy Clin Immunol. 2010 Jul;126(1):140-9. Vicario M, Blanchard C, Stringer KF, Collins MH, Mingler MK, Ahrens A, Putnam PE, Abonia JP, Santos J, Rothenberg ME. Local B cells and IgE production in the oesophageal mucosa in eosinophilic oesophagitis. Gut. 2010 Jan;59(1):12-20. Qi X, Chu Z, Mahller YY, Stringer KF, Witte DP, Cripe TP. Cancer-selective targeting and cytotoxicity by liposomal-coupled lysosomal saposin C protein. Clin Cancer Res. 2009 Sep 15;15(18):5840-51. Ahrens R, Waddell A, Seidu L, Blanchard C, Carey R, Forbes E, Lampinen M, Wilson T, Cohen E, Stringer K, Ballard E, Munitz A, Xu H, Lee N, Lee JJ, Rothenberg ME, Denson L, Hogan SP. Intestinal macrophage/epithelial cell-derived CCL11/eotaxin-1 mediates eosinophil recruitment and function in pediatric ulcerative colitis. J Immunol. 2008 Nov 15;181(10):7390-9.
Blanchard C, Mingler MK, McBride M, Putnam PE, Collins MH, Chang G, Stringer K, Abonia JP, Molkentin JD, Rothenberg ME. Periostin facilitates eosinophil tissue infiltration in allergic lung and esophageal responses. Mucosal Immunol. 2008 Jul;1(4):289-96. Collins MH, Blanchard C, Abonia JP, Kirby C, Akers R, Wang N, Putnam PE, Jameson SC, Assa'ad AH, Konikoff MR, Stringer KF, Rothenberg ME. Clinical, pathologic, and molecular characterization of familial eosinophilic esophagitis compared with sporadic cases. Clin Gastroenterol Hepatol. 2008 Jun;6(6):621-9. Shivakumar P, Sabla G, Mohanty S, McNeal M, Ward R, Stringer K, Caldwell C, Chougnet C, Bezerra JA. Effector role of neonatal hepatic CD8+ lymphocytes in epithelial injury and autoimmunity in experimental biliary atresia. Gastroenterology. 2007 Jul;133(1):268-77.
Peter H. Tang, PhD Director, Special Chemistry
Director, Special Chemistry
In vitro diagnostics; disease monitoring procedures
Mitochondrial dysfunction; metabolic disorders; neurodegenerative diseases; hemoglobin disorders; neurogenesis; and therapeutic drug monitoring
PhD: Analytical Chemistry, University of Cincinnati, Cincinnati, OH, 1990.
MS: Biochemistry, Northeast Louisiana University, Monroe, LA, 1985.
BS: Pharmacy, Taipei Medical College, Taipei, Taiwan, 1978.
Graham DL, Grace CE, Braun AA, Schaefer TL, Skelton MR, Tang PH, Vorhees CV, Williams MT. Effects of developmental stress and lead (Pb) on corticosterone after chronic and acute stress, brain monoamines, and blood Pb levels in rats. Int J Dev Neurosci. 2011 Feb;29(1):45-55.
Miles MV, Putnam PE, Miles L, Tang PH, DeGrauw AJ, Wong BL, Horn PS, Foote HL, Rothenberg ME. Acquired coenzyme Q10 deficiency in children with recurrent food intolerance and allergies. Mitochondrion. 2011 Jan;11(1):127-35.
Kohli R, Kirby M, Xanthakos SA, Softic S, Feldstein AE, Saxena V, Tang PH, Miles L, Miles MV, Balistreri WF, Woods SC, Seeley RJ. High-fructose, medium chain trans fat diet induces liver fibrosis and elevates plasma coenzyme Q9 in a novel murine model of obesity and nonalcoholic steatohepatitis. Hepatology. 2010 Sep;52(3):934-44. Miles MV, Tang PH, Miles L, Steele PE, Moye MJ, Horn PS. Validation and application of an HPLC-EC method for analysis of coenzyme Q10 in blood platelets. Biomed Chromatogr. 2008 Dec;22(12):1403-8. Tang PH. Drug monitoring and toxicology: a simple procedure for the monitoring of felbamate by HPLC-UV detection. J Anal Toxicol. 2008 Jun;32(5):373-8. Herring NR, Schaefer TL, Tang PH, Skelton MR, Lucot JP, Gudelsky GA, Vorhees CV, Williams MT. Comparison of time-dependent effects of (+)-methamphetamine or forced swim on monoamines, corticosterone, glucose, creatine, and creatinine in rats. BMC Neurosci. 2008 May 30;9:49.
Miles MV, Miles L, Tang PH, Horn PS, Steele PE, DeGrauw AJ, Wong BL, Bove KE. Systematic evaluation of muscle coenzyme Q10 content in children with mitochondrial respiratory chain enzyme deficiencies. Mitochondrion. 2008 Mar;8(2):170-80. Miles MV, Patterson BJ, Chalfonte-Evans ML, Horn PS, Hickey FJ, Schapiro MB, Steele PE, Tang PH, Hotze SL. Coenzyme Q10 (ubiquinol-10) supplementation improves oxidative imbalance in children with trisomy 21. Pediatr Neurol. 2007 Dec;37(6):398-403. Tang PH, Miles MV, Steele P, Davidson BS, Geraghty SR, Morrow AL. Determination of coenzyme Q10 in human breast milk by high-performance liquid chromatography. Biomed Chromatogr. 2006 Dec;20(12):1336-43.Tang PH. Determination of coenzyme Q10 in over-the-counter dietary supplements by high-performance liquid chromatography with coulometric detection. J AOAC Int. 2006 Jan-Feb;89(1):35-9.
Dehua Wang, MD Staff Pathologist, Department of Pathology
Staff Pathologist, Department of Pathology
Pediatric pathology; hematopathology
MD: Tongji Medical University, Yunyang Medical College, Hubei, China.
Residency: Anatomic and Clinical Pathology, Drexel University College of Medicine, Philadelphia, PA, 2008-2009; Boston University Medical Center, Boston, MA, 2009-2012.
Fellowship: Hematopathology, Indiana University School of Medicine, Indianapolis, IN, 2013; Pediatric pathology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2014.
Certification: Anatomic and Clinical Pathology, 2012; Hematopathology, 2013.
Wang D, Lane C, Quillen K. Prevalence of RhD variants, confirmed by molecular genotyping, in a multi-ethnic prenatal population. Am J Clin Pathol. 2010 Sep;134(3):438-42.
Wang D, Paz-Priel I, Friedman AD. NF-κ B p50 Regulates C/EBPα Expression and Inflammatory Cytokine-Induced Neutrophil Production. J Immunol. 2009 May 1;182(9):5757-62.
Cai DH, Wang D, Keefer J, Yeamans C, Hensley K, Friedman AD. C/EBPα:AP-1 Leucine Zipper Heterodimers Bind Novel DNA Elements, Activate the PU.1 Promoter, and Direct Monocyte Lineage Commitment More Potently Than C/EBPα Homodimers or AP-1. Oncogene. 2008 Apr 24;27(19):2772-9.
Yeamans C, Wang D, Paz-Priel I, Torbett BE, Tenen DG, Friedman AD. C/EBPα binds and activates the PU.1 distal enhancer to induce monocyte lineage commitment. Blood. 2007 Nov 1;110(9):3136-42.
Wang D, D'Costa J, Civin CI, Friedman AD. C/EBPα directs monocytic commitment of primary myeloid progenitors. Blood. 2006 Aug 15;108(4):1223 –9.
Abedin MJ, Wang D, McDonnell MA, Lehmann U, Kelekar A. Autophagy delays apoptotic death in breast cancer cells following DNA damage. Cell Death Differ. 2007 Mar;14(3):500-10.
Paz-Priel I, Cai DH, Wang D, Kowalski J, Blackford A, Liu H, Heckman CA, Gombart AF, Koeffler HP, Boxer LM, Friedman AD. CCAAT/enhancer binding protein alpha (C/EBPalpha) and C/EBPalphamyeloid oncoproteins induce bcl-2 via interaction of their basic regions with nuclear factor-kappaB p50. Mol Cancer Res. 2005 Oct;3(10):585-96.
Wang D, McDonnell MA, Kelekar A. Multi-probe RPA template sets to study RNA modulation and transcriptional control of BH3-only members of the Bcl-2 family. Cancer Detect Prev. 2005;29(2):189-200.
McDonnell MA, Wang D, Khan SM, Vander Heiden MG, Kelekar A. Caspase-9 is activated in a cytochrome c-independent manner early during TNFα-induced apoptosis in murine cells. Cell Death Differ. 2003 Sep;10(9):1005 –15.
Wang D, Liao S, Gao Z. Mulivariate analysis of prognostic factors in non-small cell lung cancer. Zhonghua Yi Xue Za Zhi. 1997 Jul;77(7):497-500.
Mikako Warren, MD
Pediatric pathology; molecular genetic pathology
University, School of Medicine, Japan.
Pediatrics, Yamaguchi University, School of Medicine, Japan; Pediatrics
(internship), University of Hawaii, Honolulu, HI; Anatomical/clinical
pathology, University of Hawaii, Honolulu, HI.
Molecular genetic pathology, Baylor College of Medicine, Houston, TX; Pediatric
pathology, Baylor College of Medicine, Houston, TX.
Warren M, Weindel M, Ringrose J, Venable C, Reyes A, Pulivarthi R, Chintagumpala M, Hicks MJ, Lopez-Terrada D, Lu XY. Integrated multimodal genetic testing of Ewing Sarcoma- a single institute experience. Human Pathology. 2013.
Warren M, Thompson KS, Popek EJ, Vogel H, Hicks J. Pericardial effusion and cardiac tamponade in neonates: sudden unexpected death associated with total parenteral nutrition via central venous catheterization. Ann Clin Lab Sci. 2013 Spring;43(2):163-71.
Warren M, Goodhue W. Cerebral tissue pulmonary embolism after severe head trauma in an infant. Am J Forensic Med Pathol. 2013 Mar;34(1):9-10.
Warren M, Luthra R, Yin C, Ravandi F, Cortes JE, Kantarjian HM, Medeiros LJ, Zuo Z. Clinical impact of change of FLT3 mutation status in acute myeloid leukemia patients. Mod Pathol. 2012 Oct;25(10):1405-12.
Warren M, Thompson KS. Two cases of primary yolk sac tumor of the liver in child hood; case reports and literature review. Pediatric Dev Pathol. 2009 Sep-Oct;12(5):410-6.
Tsunoda I, Libbey JE, Kobayashi-Warren M, Fujinami RS. IFN-gamma production and astrocyte recognition by autoreactive T cells induced by Theiler's virus infection: role of viral strains and capsid proteins. J Neuroimmunol. 2006 Mar;172(1-2):85-93.
Tsunoda I, Kuang LQ, Kobayashi-Warren M, Fujinami RS. Central nervous system Pathology caused by autoreactive CD8+ T-cell clones following virus infection. J Virol. 2005 Dec;79(23):14640-6.
Kathryn A. Wikenheiser-Brokamp, MD, PhD
Assistant Professor, Division of Pediatric Pathology
Pulmonary pathology; pediatric and adult lung diseases
BS: Mathematics/Natural Science, Secondary Education Minor, University of Mary, Bismarck, ND, 1988.
PhD: Developmental Biology, Developmental Biology and Medical Science Scholars Programs, University of Cincinnati, Cincinnati, OH, 1994.
MD: Medical Science Scholars Program, University of Cincinnati, Cincinnati, OH, 1996.
Residency: Anatomic Pathology, Department of Pathology and Immunology, Washington University-Barnes/Jewish Hospital, St. Louis, MO, 1996-2002.
Clinical Training/Postdoctoral Research: Department of Pathology and Immunology, Washington University, St. Louis, MO, 1999-2002.
Licensure: State of Ohio, 2003.
Certification: Anatomic Pathology, The American Board of Pathology, 1999.
Fuller KK, Richie DL, Feng X, Krishnan K, Stephens TJ, Wikenheiser-Brokamp KA, Askew DS, Rhodes JC. Divergent Protein Kinase A isoforms co-ordinately regulate conidial germination, carbohydrate metabolism and virulence in Aspergillus fumigatus. Mol Microbiol. 2010 Dec 17. Hagaman JT, Panos RJ, McCormack FX, Thakar CV, Wikenheiser-Brokamp KA, Shipley RT, Kinder BW. Vitamin D deficiency and reduced lung function in connective tissue-associated interstitial lung diseases. Chest. 2010 Aug 5. Simpson DS, Mason-Richie NA, Gettler CA, Wikenheiser-Brokamp KA. Retinoblastoma family proteins have distinct functions in pulmonary epithelial cells in vivo critical for suppressing cell growth and tumorigenesis. Cancer Res. 2009 Nov 15;69(22):8733-41. Young LR, Franz DN, Nagarkatte P, Fletcher CD, Wikenheiser-Brokamp KA, Galsky MD, Corbridge TC, Lam AP, Gelfand MJ, McCormack FX. Utility of [18F]2-fluoro-2-deoxyglucose-PET in sporadic and tuberous sclerosis-associated lymphangioleiomyomatosis. Chest. 2009 Sep;136(3):926-33. Wise-Draper TM, Mintz-Cole RA, Morris TA, Simpson DS, Wikenheiser-Brokamp KA, Currier MA, Cripe TP, Grosveld GC, Wells SI. Overexpression of the cellular DEK protein promotes epithelial transformation in vitro and in vivo. Cancer Res. 2009 Mar 1;69(5):1792-9.
Hoskins EE, Morris TA, Higginbotham JM, Spardy N, Cha E, Kelly P, Williams DA, Wikenheiser-Brokamp KA, Duensing S, Wells SI. Fanconi anemia deficiency stimulates HPV-associated hyperplastic growth in organotypic epithelial raft culture. Oncogene. 2009 Feb 5;28(5):674-85. Wise-Draper TM, Morreale RJ, Morris TA, Mintz-Cole RA, Hoskins EE, Balsitis SJ, Husseinzadeh N, Witte DP, Wikenheiser-Brokamp KA, Lambert PF, Wells SI. DEK proto-oncogene expression interferes with the normal epithelial differentiation program. Am J Pathol. 2009 Jan;174(1):71-81. Mason-Richie NA, Mistry MJ, Gettler CA, Elayyadi A, Wikenheiser-Brokamp KA. Retinoblastoma function is essential for establishing lung epithelial quiescence after injury. Cancer Res. 2008 Jun 1;68(11):4068-76. Mayhew CN, Carter SL, Fox SR, Sexton CR, Reed CA, Srinivasan SV, Liu X, Wikenheiser-Brokamp K, Boivin GP, Lee JS, Aronow BJ, Thorgeirsson SS, Knudsen ES. RB loss abrogates cell cycle control and genome integrity to promote liver tumorigenesis. Gastroenterology. 2007 Sep;133(3):976-84.
Ciampi R, Giordano TJ, Wikenheiser-Brokamp K, Koenig RJ, Nikiforov YE. HOOK3-RET: a novel type of RET/PTC rearrangement in papillary thyroid carcinoma. Endocr Relat Cancer. 2007 Jun;14(2):445-52.
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