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The Perinatal Institute at Cincinnati Children's is home to specialists with a variety of backgrounds and areas of focus. As a team, this diversity makes us better prepared to care for your child's unique needs.
James M. Greenberg, MD Co-Director, Perinatal Institute
Co-Director, Perinatal Institute
Director, Division of Neonatology
Professor, UC Department of Pediatrics
Neonatal chronic lung disease; late preterm infant
Binder S, Hill K, Meinzen-Derr J, Greenberg JM, Narendran V. Increasing VLBW Deliveries at Subspecialty Perinatal Centers via Perinatal Outreach. Pediatrics. 2011 Mar;127(3):487-93.
Kulkarni RM, Herman A, Ikegami M, Greenberg JM, Akeson AL. Lymphatic ontogeny and effect of hypoplasia in developing lung. Mech Dev. 2011 Jan-Feb;128(1-2):29-40. Kulkarni RM, Greenberg JM, Akeson AL. NFATc1 regulates lymphatic endothelial development. Mech Dev. 2009 May-Jun;126(5-6):350-65.
Mallory BP, Mead TJ, Wiginton DA, Kulkarni RM, Greenberg JM, Akeson AL. Lymphangiogenesis in the developing lung promoted by VEGF-A. Microvasc Res. 2006 Jul-Sep;72(1-2):62-73.
Preciado DA, Rutter MJ, Greenberg JM, Bahado-Singh R, Lambers D, Willging JP. Intrapartum management of severe fetal airway obstruction. J Otolaryngol. 2004 Oct;33(5):283-8.
Akeson AL, Cameron JE, Le Cras TD, Whitsett JA, Greenberg JM. Vascular endothelial growth factor-A induces prenatal neovascularization and alters bronchial development in mice. Pediatr Res. 2005 Jan;57(1):82-8.
Greenberg JM, Thompson FY, Brooks SK, Shannon JM, Akeson AL. Slit and robo expression in the developing mouse lung. Dev Dyn. 2004 Jun;230(2):350-60.
Le Cras TD, Spitzmiller RE, Albertine KH, Greenberg JM, Whitsett JA, Akeson AL. VEGF causes pulmonary hemorrhage, hemosiderosis, and air space enlargement in neonatal mice. Am J Physiol Lung Cell Mol Physiol. 2004 Jul;287(1):L134-42.
Akeson AL, Greenberg JM, Cameron JE, Thompson FY, Brooks SK, Wiginton D, Whitsett JA. Temporal and spatial regulation of VEGF-A controls vascular patterning in the embryonic lung. Dev Biol. 2003 Dec 15;264(2):443-55.
Greenberg JM, Thompson FY, Brooks SK, Shannon JM, McCormick-Shannon K, Cameron JE, Mallory BP, Akeson AL. Mesenchymal expression of vascular endothelial growth factors D and A defines vascular patterning in developing lung. Dev Dyn. 2002 Jun;224(2):144-53.
Louis J. Muglia, MD, PhD Co-Director, Perinatal Institute
Director, Center for Prevention of Preterm Birth
Visit the Muglia Lab
Dr. Muglia has pioneered the in vivo analyses of regulation of the endocrine stress response and the molecular pathways leading to birth using novel genetically altered mutant mice. These studies have elucidated the importance of corticotropin-releasing hormone, glucocorticoids, and prostaglandins in neuroendocrine modulation, behavior, and perinatal adaptation. These studies have evolved over the last decade to specifically focus on the mechanisms controlling the timing for birth in humans using genetics and comparative genomics. The composition of the biological clock metering the duration of human gestation remains a central question in reproductive biology. The goal of the Muglia laboratory is to understand the molecular timing machinery comprising this biological clock to prevent or better treat human preterm labor and delivery.
Among Dr. Muglia’s achievements are more than 180 publications and many awards, including a Burroughs Wellcome Fund Career Development Award in the Biomedical Sciences, the Society of Pediatric Research Young Investigator Award, and election to the American Society for Clinical Investigation and Association of American Physicians. In 2010, Dr. Muglia was elected to Fellow in the American Association for the advancement of Science. He is an active member of the Society for Pediatric Research, Society for Neuroscience, and the Lawson Wilkins Pediatric Endocrine Society. Dr. Muglia currently serves as chair of the Board of Scientific Counselors for the Eunice Kennedy Shriver National Institute of Child Health and Human Development of the National Institutes of Health. In 2013, Dr. Muglia was elected to membership in the Institute of Medicine of the National Academies.
BS: University of Michigan, Ann Arbor, MI, 1981.
PhD: University of Chicago, Chicago, IL, 1986.
MD: University of Chicago, Chicago, IL, 1988.
Muglia LJ, Jacobson L, Dikkes P, Majzoub JA. Corticotropin-releasing hormone deficiency reveals major fetal but not adult glucocorticoid need. Nature. 1995; 373:427-432.
Gross G, Imamura T, Luedke C, Vogt SK, Olson LM, Nelson DM, Sadovsky Y, Muglia LJ. Opposing actions of prostaglandins and oxytocin determine the onset of murine labor. Proc. Natl. Acad. Sci. USA. 1998; 95: 11871-11875.
Bethin KE, Nagai Y, Sladek R, Asada M, Sadovsky Y, Hudson TJ, Muglia LJ. Microarray analysis of uterine gene expression in mouse and human pregnancy. Mol Endocrinol. 2003; 17: 1454-1469.
Kistka Z A-F, Palomar P, Lee KA, Boslaugh SE, Wangler MF, Cole FS, DeBaun MR, Muglia LJ. Racial disparity in the frequency of recurrence of preterm birth. Am J Obstet Gynecol. 2007; 196: 131.e1-131.e6.
Roizen J, Asada M, Tong M, Tai H-H, Muglia LJ. Preterm birth without progesterone withdrawal in 15-hydroxyprostaglandin dehydrogenase hypomorphic mice. Mol Endocrinol. 2008; 22: 105-112.
Kolber BJ, Roberts MS, Howell MP, Wozniak DF, Sands MS, Muglia LJ. Central amygdala glucocorticoid receptor action promotes fear-associated CRH activation and conditioning. Proc Natl Acad Sci USA. 2008; 105: 12004 - 12009.
Plunkett J, Feitosa MF, Trusgnich M, Wangler MF, Palomar L, Kistka ZA-F, DeFranco EA, Shen TT, Stormo EAD, Puttonen H, Hallman M, Haataja R, Luukkonen A, Fellman V, Peltonen L, Palotie A, Daw EW, An P, Teramo K, Borecki I, Muglia LJ. Mother’s genome or maternally-inherited genes acting in the fetus influence gestational age in familial preterm birth. Human Heredity. 2009; 68: 209-219.
Kolber BJ, Boyle MP, Wieczorek L, Kelley CL, Kelley CL, Onwuzurike CC, Nettles SA, Vogt SK, Muglia LJ. Transient early-life forebrain corticotropin-releasing hormone elevation causes long-lasting anxiogenic and despair-like changes in mice. J Neurosci. 2010; 30: 2571-2581.
Muglia LJ, Katz M. The enigma of spontaneous preterm birth. N Engl J Med. 2010; 362: 529-535.
Plunkett J, Doniger S, Orabona G, Morgan T, Haataja R, Hallman M, Puttonen H, Menon R, Kuczynski E, Norwitz E, Victoria Snegovskikh V, Palotie A, Peltonen L, Fellman V, DeFranco EA, Chaudhari BP, McGregor TL, McElroy JJ, Oetjens MT, Teramo K, Boreck I, Fay J, Muglia L. An evolutionary genomic approach to identify genes involved in human birth timing. PLoS Genetics. 2011; 7: e1001365.
Amygdala Glucocorticoid Receptor Function in Stress. Principle Investigator. NIH/NIMH. Feb 2009-Dec 2014.
Maternal Temperament, Stress, Inflammation and Preterm Birth. Multi-PI. NIH/NICHD. Sep 2013-Aug 2017.
Genetic Analysis of Human Preterm Birth. Principle Investigator. March of Dimes. Mar 2005-Feb 2014.
March of Dimes Prematurity Research Center Ohio Collaborative. Coordinating PI. March of Dimes. Jul 2013-Jun 2018.
Burroughs Wellcome Fund Research Consortium on Preterm Birth. Director. Burroughs Wellcome. Oct 2007-Sep 2014.
Jeffrey A. Whitsett, MD Co-Director, Perinatal Institute
Chief, Section of Neonatology, Perinatal and Pulmonary Biology
Cystic fibrosis research; lung morphogenesis; control of gene expression in the respiratory epithelium; gene delivery and therapy
Visit the Whitsett Lab.
Jeffrey A. Whitsett, MD, is chief of the Section of Neonatology, Perinatal and Pulmonary Biology at Cincinnati Children's Hospital Medical Center.
Dr. Whitsett received his medical degree from Columbia University, in New York, and has been a faculty member since 1977. He is internationally known for his research in pulmonary medicine, as well as for his clinical expertise in neonatology.
Dr. Whitsett has made a series of groundbreaking contributions in pulmonary medicine. His major pioneering work has been on surfactant proteins A, B, C and D, cloning their genes, and clarifying their roles in lung development.
Throughout his career, Dr. Whitsett has had the remarkable ability to move from molecular biology, to animal models, to diagnosis and therapy of human disease. He played a critical role in making surfactant protein replacement a routine tool for treating immature lungs and respiratory distress syndrome in premature infants. His laboratory has contributed to the identification of a number of genes critical for lung formation and function. Mutations in genes regulating surfactant homeostasis were shown to cause acute and chronic lung disease in infants and adults.
Dr. Whitsett is a member of the Institute of Medicine, National Academy of Sciences and is the recipient of the Mead Johnson Award, a National Institutes of Health (NIH) Merit Award, the first Julius Comroe Lectureship in Pulmonary Research from FASEB, the William Cooper Procter Award from Cincinnati Children's, the Amberson Lecture Award of the American Thoracic Society, the prestigious Daniel Drake Medal for scientific contributions from the University of Cincinnati College of Medicine, the International Arvo Ylppö Medal from the Finnish Foundation for Pediatric Research and the Grand Hamdan International Award on Neonatal Medicine from the United Arab Emirates.
Dr. Whitsett is the author of more than 400 papers in both the basic science and clinical literature.
MD: Columbia University, New York, NY, 1973.
Residency: Pediatrics, Mt. Sinai Hospital, New York City, 1974 to 1976.
Fellowship: Neonatology, Children's Hospital Medical Center, University of Cincinnati College of Medicine, 1976 to 1977.
Sivaprasad U, Askew DJ, Ericksen MB, Gibson AM, Stier MT, Brandt EB, Bass SA, Daines MO, Chakir J, Stringer KF, Wert SE, Whitsett JA, Le Cras TD, Wills-Karp M, Silverman GA, Khurana Hershey GK. A nonredundant role for mouse Serpinb3a in the induction of mucus production in asthma. J Allergy Clin Immunol. 2011 Jan;127(1):254-61, 261.e1-6. Lin SC, Wani MA, Whitsett JA, Wells JM. Klf5 regulates lineage formation in the pre-implantation mouse embryo. Development. 2010 Dec;137(23):3953-63. Suzuki T, Sakagami T, Young LR, Carey BC, Wood RE, Luisetti M, Wert SE, Rubin BK, Kevill K, Chalk C, Whitsett JA, Stevens C, Nogee LM, Campo I, Trapnell BC. Hereditary pulmonary alveolar proteinosis: pathogenesis, presentation, diagnosis, and therapy. Am J Respir Crit Care Med. 2010 Nov 15;182(10):1292-304. Wang IC, Zhang Y, Snyder J, Sutherland MJ, Burhans MS, Shannon JM, Park HJ, Whitsett JA, Kalinichenko VV. Increased expression of FoxM1 transcription factor in respiratory epithelium inhibits lung sacculation and causes Clara cell hyperplasia. Dev Biol. 2010 Nov 15;347(2):301-14. Perl AK, Riethmacher D, Whitsett JA. Conditional Depletion of Airway Progenitor Cells Induces Peribronchiolar Fibrosis. Am J Respir Crit Care Med. 2010 Sep 24.
Tompkins DH, Besnard V, Lange AW, Keiser AR, Wert SE, Bruno MD, Whitsett JA. Sox2 Activates Cell Proliferation and Differentiation in the Respiratory Epithelium. Am J Respir Cell Mol Biol. 2010 Sep 20. Meyer SE, Hasenstein JR, Baktula A, Velu CS, Xu Y, Wan H, Whitsett JA, Gilks CB, Grimes HL. Kruppel-like factor 5 is not required for K-RasG12D lung tumorigenesis, but represses ABCG2 expression and is associated with better disease-specific survival. Am J Pathol. 2010 Sep;177(3):1503-13. Xu Y, Zhang M, Wang Y, Kadambi P, Dave V, Lu LJ, Whitsett JA. A systems approach to mapping transcriptional networks controlling surfactant homeostasis. BMC Genomics. 2010 Jul 26;11:451. Sakagami T, Beck D, Uchida K, Suzuki T, Carey BC, Nakata K, Keller G, Wood RE, Wert SE, Ikegami M, Whitsett JA, Luisetti M, Davies S, Krischer JP, Brody A, Ryckman F, Trapnell BC. Patient-derived granulocyte/macrophage colony-stimulating factor autoantibodies reproduce pulmonary alveolar proteinosis in nonhuman primates. Am J Respir Crit Care Med. 2010 Jul 1;182(1):49-61. Chen G, Wan H, Luo F, Zhang L, Xu Y, Lewkowich I, Wills-Karp M, Whitsett JA. Foxa2 programs Th2 cell-mediated innate immunity in the developing lung. J Immunol. 2010 Jun 1;184(11):6133-41.
Sheela Rath Geraghty, MD, MS, IBCLC, FAAP Medical Director, Center for Breastfeeding Medicine
Medical Director, Center for Breastfeeding Medicine
Associate Professor, UC Department of Pediatrics
Breastfeeding, breast milk pumping, human milk banking, multiple births
Sheela R. Geraghty, MD, is a general pediatrician and lactation consultant. Dr. Geraghty is the medical director for the Cincinnati Children’s Center for Breastfeeding Medicine. Dr. Geraghty’s research and clinical practice focuses on barriers to successful breastfeeding.
Keim SA, Hogan JS, McNamara KA, Gudimetla V, Dillon CE, Kwiek JJ, Geraghty SR. Microbial contamination of human milk purchased on the internet. Pediatrics. 2013 Nov;132(5):e1227-35.
Keim SA, McNamara KA, Jayadeva CM, Braun AC, Dillon CE, Geraghty SR. Breast milk sharing via the internet: The practice and health and safety considerations. Matern Child Health J. 2013 Oct 25. Epub ahead of print.
Keim SA, Hogan JS, McNamara KA, Gudimetla V, Dillon CE, Kwiek JJ, Geraghty SR. Microbial contamination of human milk purchased on the internet. Pediatrics. 2013 Oct 21. Epub ahead of print.
Geraghty SR, McNamara KA, Dillon CE, Hogan JS, Kwiek JJ, Keim SA. Buying human milk via the Internet: Just a Click Away. Breastfeed Med. 2013 Dec;8:474-8.
Geraghty SR, Sucharew H, Rasmussen KM. Trends in breastfeeding: It’s not only at the breast any more. Matern Child Nutr. 2013 Apr;9(2):180-7.
Geraghty SR, Saluja K, Merchant M. Breastfeeding Disparities: Challenges and Solutions. Infant, Child, & Adolescent Nutrition. 2012;4(4):207-214.
Martin MA, Lassek WD, Gaulin SJ, Evans RE, Woo JG, Geraghty SR, Davidson BS, Morrow AL, Kaplan HS, Gurven MD. Fatty acid composition in the mature milk of Bolivian forager-horticulturalists: comparisons with a U.S. sample. Matern Child Nutr. 2012 Jul;8(3):404-18.
Geraghty S, Tabangin ME, Davidson BS, Morrow AL. Predictors of Breast Milk Expression by One Month Postpartum and Influence on Breast Milk Feeding Duration. Breastfeed Med. 2012 Apr;7(2):112-7.
Rasmussen KM, Geraghty SR. The quiet revolution: Breastfeeding transformed with the use of breast pumps. Am J Public Health. 2011 Aug;101(8):1356-9.
Geraghty SR, Heier JE, Rasmussen KM. Got Milk? Sharing human milk via the internet. Public Health Rep. 2011 Mar-Apr;126(2):161-4.
Sarah W. Riddle, MD, IBCLC, FAAP Attending Physician, Division of Hospital Medicine
Attending Physician, Division of Hospital Medicine
Assistant Professor, UC Department of Pediatrics
Hospitalist medicine; breastfeeding medicine
Sarah Riddle, MD, IBCLC sees mothers and infants in the Breastfeeding Medicine Clinic and is an attending hospitalist on the inpatient units at Cincinnati Children’s Hospital Medical Center. She has a specialized interest in effects of acute hospitalization on the breastfeeding dyad.
MD: Johns Hopkins University School of Medicine, Baltimore, MD, 2001.IBCLC: International Board Certified Lactation Consultant, 2008.
Residency: Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2001-2004.
Chief Residency: Pediatrics, Cincinnati Children's Hospital Medical Center 2004-2005.
Certification: Pediatrics, 2004.
Geraghty SR, Riddle SW, Shaikh U. The breastfeeding mother and the pediatrician. J Hum Lactat. 2008;24(3):335-9.
List BA, Ballard JL, Langworthy KS, Vincent AM, Riddle SW, Tamayo OW, Geraghty SR. Electronic health records in an outpatient breastfeeding medicine clinic. J Hum Lactat. 2008 Feb;4(1):58-68.
Ellen S. Springer, MD, IBCLC Staff Physician
Ellen S. Springer, MD, works with the Center for Breast Feeding Medicine in an outpatient setting at Cincinnati Children’s Hospital Medical Center. She assists mothers and infants with breast feeding related issues.
MD: The Ohio State University College, Columbus, OH, 1995.
Residency: Cincinnati Children's Hospital Medical Center, 1998.
Certification: Board Certified, Pediatrics.
Jason S. Frischer, MD Director, Peña Colorectal Center
Director, Peña Colorectal Center
Director, Extracorporeal Membrane Oxygenation (ECMO) Program
Division of Pediatric General and Thoracic Surgery
Assistant Professor, UC Department of Surgery
Chernoguz A, Crawford, K, Vandersall A, Willson T, Denson LA, Frischer JS. Pre-treatment with Anti-VEGF therapy may exacerbate inflammation in experimental acute colitis. J Pediatr Surg. 2012 Feb;47(2):347-54.
Le LD, Keswani SG, Biesiada J, Lim FY, Kingma PS, Haberman BE, Frischer J, Habli M, Crombleholme TM. The congenital diaphragmatic hernia composite prognostic index correlates with survival in left-sided congenital diaphragmatic hernia. J Pediatr Surg. 2012 Jan;47(1):57-62.
Lawal TA, Falcone RA, von Allmen D, Denson LA, Levitt MA, Warner BW, Frischer JS. The utility of routine pouchogram before ileostomy reversal in children and adolescents following ileal pouch anal anastomosis. J Pediatr Surg. 2011 Jun;46(6):1222-5.
Chernoguz A, Crawford KM, Donovan EC, Vandersall AE, Berglund C, Cripe TP, Frischer JS. EGFR Inhibition Fails to Suppress Vascular Proliferation and Tumor Growth in a Ewing’s Sarcoma Model. J Surg Res. 2012 Mar;173(1):1-9.
Lawal TA, Frischer JS, Falcone RA, Chatoorgoon K, Denson LA, Levitt MA. The transanal approach with laparoscopy or laparotomy for the treatment of rectal strictures in Crohn’s disease. J Laparoendosc Adv Surg Tech A. 2010 Nov;20(9):791-5.
Bischoff A, Gupta A, D’Mello S, Mezoff A, Podberesky D, Barnett S, Keswani S, Frischer JS. Crohn’s disease limited to the appendix: a case report in a pediatric patient. Pediatr Surg Int. 2010 Nov;26(11):1125-8.
Vuletin JF, Lim FY, Cnota J, Kline-Fath B, Salisbury S, Haberman B, Kingma P, Frischer JS, Crombleholme T. Prenatal pulmonary hypertension index: novel prenatal predictor of severe postnatal pulmonary artery hypertension in antenatally diagnosed congenital diaphragmatic hernia. J Pediatr Surg. 2010 Apr;45(4):703-8.
Frischer JS, Lee A, Serur A, Huang J, Bae JO, Kornfield ZN, Eljuga L, Shawber CJ, Feirt N, Mansukhani M, Stempak D, Baruchel S, Bender JG, Kandel JJ, Yamashiro DJ. Inhibition of cyclooxygenase-2 disrupts tumor vascular mural cell recruitment and survival signaling. Cancer Res. 2006 Apr;66(8):4378-84.
Frischer JS, Huang J, Serur A, Kadenhe-Chiweshe A, McCrudden KW, O’Toole K, Holash J, Yancopoulos GD, Yamashiro DJ, Kandel JJ. Effects of potent VEGF blockade on experimental Wilms tumor and its persisting vasculature. Int J Onc. 2004 Sep;25(3):549-53.
Huang J, Frischer JS, Serur A, Kadenhe A, Yokoi A, McCrudden KW, New T, O’Toole K, Zabski S, Rudge JS, Holash J, Yancopoulos GD, Yamashiro DJ, Kandel JJ. Regression of established tumors and metastases by potent vascular endothelial growth factor blockade. Proc Natl Acad Sci USA. 2003 June 24;100(13):7785-90.
Beth E. Haberman, MD Senior Medical Director, Neonatal Services
Senior Medical Director, Neonatal Services
Medical Director, Newborn Intensive Care Unit (NICU)
Medical Director, Neonatal Transport Program
Associate Director, High-Risk Infant Follow-Up Program
CDH and infant follow-up; care of infants with congenital diaphragmatic hernia; follow-up care of premature and term infants with complex medical needs
Vuletin JF, Lim FY, Cnota J, Kline-Fath B, Salisbury S, Haberman B, Kingma P, Frischer J, Crombleholme T. Prenatal pulmonary hypertension index: novel prenatal predictor of severe postnatal pulmonary artery hypertension in antenatally diagnosed congenital diaphragmatic hernia. J Pediatr Surg. 2010 Apr;45(4):703-8.Greenberg JM, Donovan EF, Warner BB, Haberman BE, Narendran V, Schibler KR. Neonatal Morbidities of Prenatal and Perinatal Origin. Creasy and Resnik”s Maternal-Fetal Medicine: Principles and Practice. 2008 6th ed. Chapter 58. Elsevier Ltd., Philadelphia, PA.Castro L, Yolton K, Haberman B, Roberto N, Hansen NI, Ambalavanan N, Vohr BR, Donovan EF. Bias in reported neurodevelopmental outcomes among extremely low birth weight survivors. Pediatrics. 2004 Aug;114(2):404-10.
Sundeep G. Keswani, MD Pediatric Surgeon, Division of General, Thoracic and Fetal Surgery
Pediatric Surgeon, Division of General, Thoracic and Fetal Surgery
Fetal Surgeon, Cincinnati Fetal Center
Director, Pediatric Advanced Wound Care and Skin Services
Gene therapy applications; bone marrow contribution to tissue repair; fetal diagnosis and treatment.
Visit the Keswani Lab.
Dr. Sundeep G. Keswani is a pediatric and fetal surgeon. He is also the director of the Pediatric Advanced Wound Care and Skin Service (PAWS), which is a state-of-the-art wound care center devoted to the care of children. Dr. Keswani is the lead principal investigator in the Cincinnati Children’s Wound Healing Research Group, which is an NIH-funded laboratory that focuses on understanding the molecular mechanisms which underlie the fetus’ ability to regeneratively heal wounds with the goal of developing novel therapeutics to achieve regenerative wound healing in postnatal tissue.
Alice King MD, Swathi Balaji PhD, Louis D. Le MD, Emily Marsh, Timothy M. Crombleholme MD, Sundeep G. Keswani MD. Interleukin-10 Regulates Fetal Extracellular Matrix Hyaluronan Production. Journal of Pediatric Surgery. (In press).
Visscher M, King A, Nie AM, Schaffer P, Taylor T, Pruitt D, Giaccone MJ, Ashby M, Keswani S. A Quality-Improvement Collaborative Project to Reduce Pressure Ulcers in PICUs. Pediatrics. 2013 Jun;131(6):e1950-60.
Keswani SG, Balaji S, Le LD, Leung A, Parvadia JK, Frischer J, Yamano S, Taichman N, Crombleholme TM. Role of salivary vascular endothelial growth factor (VEGF) in palatal mucosal wound healing. Wound Repair Regen. 2013 Jun 11.
King A, Balaji S, Marsh E, Le LD, Shaaban AF, Crombleholme TM, Keswani SG. Interleukin-10 regulates the fetal hyaluronan-rich extracellular matrix via a STAT3-dependent mechanism. J Surg Res. 2013 Apr 24.
Balaji S, King A, Dhamija Y, Le LD, Shaaban AF, Crombleholme TM, Keswani SG. Pseudotyped adeno-associated viral vectors for gene transfer in dermal fibroblasts: implications for wound-healing applications. J Surg Res. 2013 Apr 3.
Keswani SG, Balaji S, Le L, Leung A, Katz AB, Lim FY, Habli M, Jones HN, Wilson JM, Crombleholme TM. Pseudotyped AAV vector-mediated gene transfer in a human fetal trachea xenograft model: implications for in utero gene therapy for cystic fibrosis. PLoS One. 2012;7(8):e43633.
Keswani SG, Balaji S, Le L, Leung A, Lim FY, Habli M, Jones HN, Wilson JM, Crombleholme TM. Pseudotyped adeno-associated viral vector tropism and transduction efficiencies in murine wound healing. Wound Repair Regen. 2012 Jul-Aug;20(4):592-600.
Gordon A, Kozin ED, Keswani SG, Vaikunth SS, Katz AB, Zoltick PW, Favata M, Radu AP, Soslowsky LJ, Herlyn M, Crombleholme TM. Permissive environment in postnatal wounds induced by adenoviral-mediated overexpression of the anti-inflammatory cytokine interleukin-10 prevents scar formation. Wound Repair Regen. 2008 Jan-Feb;16(1):70-9.
Javazon EH, Keswani SG, Badillo AT, Crombleholme TM, Zoltick PW, Radu AP, Kozin ED, Beggs K, Malik AA, Flake AW. Enhanced epithelial gap closure and increased angiogenesis in wounds of diabetic mice treated with adult murine bone marrow stromal progenitor cells. Wound Repair Regen. 2007 May-Jun;15(3):350-9.
Keswani SG, Katz AB, Lim FY, Zoltick P, Radu A, Alaee D, Herlyn M, Crombleholme TM. Adenoviral mediated gene transfer of PDGF-B enhances wound healing in type I and type II diabetic wounds. Wound Repair Regen. 2004 Sep-Oct;12(5):497-504.
Paul S. Kingma, MD, PhD Neonatal Director, Cincinnati Fetal Center
Neonatal Director, Cincinnati Fetal Center
Neonatology; congenital diaphragmatic hernia; neonatal infection
Innate immune systems; surfactant protein D; neutrophil function in cystic fibrosis
Foong-Yen Lim, MD Surgical Director, Cincinnati Fetal Center
Surgical Director, Cincinnati Fetal Center
Associate Professor, UC Department of Surgery
Open fetal surgery and fetoscopic surgery; ex-utero intrapartum treatment (EXIT); congenital high airway obstruction syndrome (CHAOS); congenital diaphragmatic hernia (CDH); fetal gene therapy; neonatal surgery; thoracic surgery; minimally invasive surgery
Visit the Lim Lab.
William J. Polzin, MD MFM Co-Director, Cincinnati Fetal Center
MFM Co-Director, Cincinnati Fetal Center
BA: University of Wisconsin-Milwaukee; University of Wisconsin-Madison.
MD: Medical College of Wisconsin, Milwaukee, Wisconsin, 1983.Internship: Obstetrics and Gynecology, Madigan Army Medical Center, Tacoma, Washington, 1983-1984.Residency: Obstetrics and Gynecology, Madigan Army Medical Center, Tacoma, Washington, 1984-1987.Fellowship: Maternal-Fetal Medicine, Madigan Army Medical Center, Tacoma, Washington, 1989-1991.
James W. Van Hook, MD MFM Co-Director, Cincinnati Fetal Center
Tanya E. Cahill, MD Director, High-Risk Clinic
Director, High-Risk Clinic
High risk infant follow up; neonatal abstinence syndrome
Thomas R. Korfhagen, MD, PhD Attending Pediatrician, Neonatology and Pulmonary Biology
Attending Pediatrician, Neonatology and Pulmonary Biology
Care of high-risk infants; pediatric patients with complex, long term medical problems
Roles and mechanisms whereby surfactant proteins A, B, D, Relm peptides and EGF-R signaling control lung infections, inflammation and responses to lung injury. Translational studies assessing processes to reduce the extent of lung injury and remodeling in neonates and adults.
Hassett DJ, Korfhagen TR, Irvin RT, Schurr MJ, Sauer K, Lau GW, Sutton MD, Yu H, Hoiby N. Pseudomonas aeruginosa biofilm infections in cystic fibrosis: insights into pathogenic processes and treatment strategies. Expert Opin Ther Targets. 2010 Feb;14(2):117-30. Review.
Le Cras TD, Korfhagen TR, Davidson C, Schmidt S, Fenchel M, Ikegami M, Whitsett JA, Hardie WD. Inhibition of PI3K by PX-866 prevents transforming growth factor-alpha-induced pulmonary fibrosis. Am J Pathol. 2010 Feb;176(2):679-86.
Chen G, Korfhagen TR, Xu Y, Kitzmiller J, Wert SE, Maeda Y, Gregorieff A, Clevers H, Whitsett JA. SPDEF is required for mouse pulmonary goblet cell differentiation and regulates a network of genes associated with mucus production. J Clin Invest. 2009 Oct;119(10):2914-24.
Deshmukh HS, McLachlan A, Atkinson JJ, Hardie WD, Korfhagen TR, Dietsch M, Liu Y, Di PY, Wesselkamper SC, Borchers MT, Leikauf GD. Matrix metalloproteinase-14 mediates a phenotypic shift in the airways to increase mucin production. Am J Respir Crit Care Med. 2009 Nov 1;180(9):834-45.
Glasser SW, Witt TL, Senft AP, Baatz JE, Folger D, Maxfield MD, Akinbi HT, Newton DA, Prows DR, Korfhagen TR. Surfactant protein C-deficient mice are susceptible to respiratory syncytial virus infection. Am J Physiol Lung Cell Mol Physiol. 2009 Jul;297(1):L64-72.
Korfhagen TR, Le Cras TD, Davidson CR, Schmidt SM, Ikegami M, Whitsett JA, Hardie WD. Rapamycin prevents transforming growth factor-alpha-induced pulmonary fibrosis. Am J Respir Cell Mol Biol. 2009 Nov;41(5):562-72.
Kramer EL, Mushaben EM, Pastura PA, Acciani TH, Deutsch GH, Khurana Hershey GK, Korfhagen TR, Hardie WD, Whitsett JA, Le Cras TD. Early growth response-1 suppresses epidermal growth factor receptor-mediated airway hyperresponsiveness and lung remodeling in mice. Am J Respir Cell Mol Biol. 2009 Oct;41(4):415-25.
Glasser SW, Senft AP, Whitsett JA, Maxfield MD, Ross GF, Richardson TR, Prows DR, Xu Y, Korfhagen TR. Macrophage dysfunction and susceptibility to pulmonary Pseudomonas aeruginosa infection in surfactant protein C-deficient mice. J Immunol. 2008 Jul 1;181(1):621-8.
Hardie WD, Davidson C, Ikegami M, Leikauf GD, Le Cras TD, Prestridge A, Whitsett JA, Korfhagen TR. EGF receptor tyrosine kinase inhibitors diminish transforming growth factor-alpha-induced pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol. 2008 Jun;294(6):L1217-25.
Deshmukh HS, Shaver C, Case LM, Dietsch M, Wesselkamper SC, Hardie WD, Korfhagen TR, Corradi M, Nadel JA, Borchers MT, Leikauf GD. Acrolein-activated matrix metalloproteinase 9 contributes to persistent mucin production. Am J Respir Cell Mol Biol. 2008 Apr;38(4):446-54.
Stephanie L. Merhar, MD, MS Attending Neonatologist
Merhar S. Biomarkers in neonatal posthemorrhagic hydrocephalus. Neonatology. 2011 Jul;101(1):1-7.
Merhar SL, Schibler KR, Sherwin CM, Meinzen-Derr J, Shi J, Balmakund T, Vinks AA. Pharmacokinetics of levetiracetam in neonates with seizures. J Pediatrics. 2011 Jul;159(1):152-154. Merhar SL, Manning-Courtney P. Two boys with 47 XXY and autism. J Autism Devl Disord. 2007 May;37(5):840-6. Merhar SL, Gilbert DL. Clinical (video) findings and cerebrospinal fluid neurotransmitters in 2 children with severe chronic bilirubin encephalopathy, including a former preterm infant without marked hyperbilirubinemia. Pediatrics. 2005 Nov;116(5):1226-30. Levy SE, Mandell DS, Merhar SL, Ittenbach RF, Pinto-Martin JA. Use of complementary and alternative medicine among children recently diagnosed with autistic spectrum disorder. J Dev Behav Ped. 2003 Dec;24(6):418-423.
Ajay B. Ponkshe, MD Staff Physician, Neonatology
Staff Physician, Neonatology
Henry T. Akinbi, MD Attending Neonatologist
Neonatal infections; blood transfusions; role of Lysozyme in airway host defense
McDowell SA, Ma Y, Kusano R, Akinbi HT. Simvastatin is Protective During Staphylococcus aureus Pneumonia. Curr Pharm Biotechnol. 2011 Mar 14.
Kuang Z, Hao Y, Hwang S, Zhang S, Kim E, Akinbi HT, Schurr MJ, Irvin RT, Hassett DJ, Lau GW. The Pseudomonas aeruginosa flagellum confers resistance to pulmonary surfactant protein-A by impacting the production of exoproteases through quorum-sensing. Mol Microbiol. 2011 Mar;79(5):1220-35.
Isemann B, Meinzen-Derr J, Akinbi H. Maternal and neonatal factors impacting response to methadone therapy in infants treated for neonatal abstinence syndrome. J Perinatol. 2011 Jan;31(1):25-9. Slaughter JL, Meinzen-Derr J, Rose SR, Leslie ND, Chandrasekar R, Linard SM, Akinbi HT. The effects of gestational age and birth weight on false-positive newborn-screening rates. Pediatrics. 2010 Nov;126(5):910-6.
Akinbi H, Meinzen-Derr J, Auer C, Ma Y, Pullum D, Kusano R, Reszka KJ, Zimmerly K. Alterations in the host defense properties of human milk following prolonged storage or pasteurization. J Pediatr Gastroenterol Nutr. 2010 Sep;51(3):347-52. Yang L, Johansson J, Ridsdale R, Willander H, Fitzen M, Akinbi HT, Weaver TE. Surfactant protein B propeptide contains a saposin-like protein domain with antimicrobial activity at low pH. J Immunol. 2010 Jan 15;184(2):975-83. Glasser SW, Witt TL, Senft AP, Baatz JE, Folger D, Maxfield MD, Akinbi HT, Newton DA, Prows DR, Korfhagen TR. Surfactant protein C-deficient mice are susceptible to respiratory syncytial virus infection. Am J Physiol Lung Cell Mol Physiol. 2009 Jul;297(1):L64-72. Walker VP, Akinbi HT, Meinzen-Derr J, Narendran V, Visscher M, Hoath SB. Host defense proteins on the surface of neonatal skin: implications for innate immunity. J Pediatr. 2008 Jun;152(6):777-81.
Nash JA, Ballard TN, Weaver TE, Akinbi HT. The peptidoglycan-degrading property of lysozyme is not required for bactericidal activity in vivo. J Immunol. 2006 Jul 1;177(1):519-26 Ryan MA, Akinbi HT, Serrano AG, Perez-Gil J, Wu H, McCormack FX, Weaver TE. Antimicrobial activity of native and synthetic surfactant protein B peptides. J Immunol. 2006 Jan 1;176(1):416-25.
Mary C. Burwinkel, MD Staff Physician, Neonatology and Pulmonary Biology
Staff Physician, Neonatology and Pulmonary Biology
Michael W. Crossman, MD, PhD Attending Neonatologist
Intestinal function and host-microbial interactions; bioethics and neonatal palliative care
PhD: Biochemistry, St. Louis University, St. Louis, MO, 1985.
MD: St. Louis University, St. Louis, MO, 1986.
Residency: Pediatrics, Children's Hospital Medical Center, Cincinnati, Ohio, 1986-1989; Chief resident, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, 1989-1990.
Fellowship: Neonatal- Perinatal Medical Fellowship, Washington University School of Medicine, 1990-1993.Certification: Neonatal - Perinatal Medicine, 1995, 2003.
Crossman MW. For Whom the Bells Toll… J Pediatrics. 2007;151(1):4-5.
Mishra A, Hogan SP, Brandt EB, Wagner N, Crossman MW, Foster PS, Rothenberg ME. Enterocyte expression of the eotaxin and interleukin-5 transgenes induces compartmentalized dysregulation of eosinophil trafficking. J Biol Chem. 2002 Feb 8;277(6):4406-12. Arrese M, Trauner M, Sacchiero RJ, Crossman MW, Scheider BL. Neither Intestinal Sequestration of Bile Acids nor Common Bile Duct Ligation Modulate the Expression and Function of the Rat Ileal Bile Acid Transporter. Hepatology. 1998;28:1081-1087.
Shneider BL, Setchell KDR, Crossman MW. Fetal and Neonatal Expression of the Apical Sodium-Dependent Bile Acid Transporter in the Rat Ileum and Kidney. Pediatric Research. 1997;42:189-194.
Diane K. Donley, MD Staff Physician, Neonatology
Teen pregnancy; parent education
Jay H. Dritz, MD Attending Neonatologist
MD: Washington University School of Medicine, St. Louis, MO, 2001.
Residency: Pediatrics, St. Louis Children’s Hospital, St. Louis, MO, 2001-2004.
Fellowship: Neonatal-Perinatal Medicine, St. Louis Children’s Hospital, St. Louis, MO, 2004-2007.
Certification: Pediatrics, 2004; Neonatology, 2008.
Horacio S. Falciglia, MD
Meconium aspiration syndrome; pathophysiology
Relationship of Selenium Status to Sepsis in extremely premature infants
Horacio Falciglia, MD, serves as the director of the Vermont Oxford Database, where he finds his work both challenging and interesting. This work allows the division to compare local (Cincinnati) neonatal outcomes, morbidities, and mortality in premature infants under 1500 grams with 600 other NICUs in the US and abroad. Dr. Falciglia also enjoys sharing years of clinical experience with new graduates and students as he teaches medical students and residents at the bedside. Dr. Falciglia's past research on meconium aspiration has been exciting and rewarding, and his research is leading to the understanding of the pathophysiology of this complex disease. The incidence of this disease has been drastically reduced through research and improved perinatal care.
MD: University of Buenos Aires, Argentina, 1967. Residency: Pediatrics, Lincoln Hospital, Albert Einstein College, 1973. Fellowship: Neonatology, New York University, Bellevue Hospital, 1976.
Certification: General pediatrics.
Neera K. Goyal, MD, MSc Attending Physician, Division of Hospital Medicine
Hospital medicine; level 1 and level 2 nursery care
Perinatal health services; home visiting; preterm birth
As a Robert Wood Johnson Foundation Clinical Scholar at the University of Pennsylvania (2009-2011), Dr. Goyal studied the impact of delivery volume, teaching affiliation, and patient insurance on adherence to guidelines for postpartum length of stay, as well as the impact of discharge timing on readmission risk. She also conducted research on the impact of late preterm birth on early childhood respiratory morbidity and physical development.
She joined Cincinnati Children’s Hospital Medical Center in 2011 as a faculty member with a joint appointment in the Division of Neonatology and the Division of Hospital Medicine. In 2012 she received the BIRCWH K12 Award to evaluate the role of community-based home visiting to improve pregnancy and infant health outcomes. Currently, Dr. Goyal is studying programmatic effects on health care utilization in ED and primary care settings for full term and preterm infants.
BA: Emory University, Atlanta, GA, 2001.
MD: University of Texas Southwestern Medical Center in Dallas, Dallas, TX, 2005.
MSc: Health Policy Research, University of Pennsylvania, Philadelphia, PA, 2011.
Residency: Children's Hospital of Philadelphia, Philadelphia, PA, 2008.
Moyer LB, Goyal NK, Meinzen-Derr JK, Ward LP, Rust CL, Wexelblatt SL, Greenberg, JM. Factors Associated with Readmission in Late Preterm Infants: A Matched Case Control Study. Hospital Pediatrics. 2014. In Press.
Simpson E, Goyal NK, Dhepyasuwan N, Flaherman V, Chung EK, Von Kohorn I, Burgos A, Taylor J. Prioritizing a Research Agenda: A Delphi Study of the Better Outcomes through Research for Newborns (BORN) Network. Hospital Pediatrics. 2014. In Press.
Goyal NK, Hall ES, Ammerman RT, Meinzen-Derr JK, Jones DE, Short JA, Van Ginkel JB. Association of maternal and community factors with enrollment in home visiting among at-risk, first time mothers. Am J Public Health. 2014 Feb;104 Suppl 1:S144-51.
Hall ES, Goyal NK*, Ammerman RT, Miller MM, Jones DE, Short JA, Van Ginkel JB. Development of a linked perinatal data resource from state administrative and community-based program data. Matern Child Health J. 2014 Jan;18(1):316-25.
Goyal NK, Hall ES, Meinzen-Derr JK, Kahn RS, Short JA, Van Ginkel JB, Ammerman RT. Dosage effect of prenatal home visiting on pregnancy outcomes in at-risk, first-time mothers. Pediatrics. 2013 Nov;132 Suppl 2:S118-25.
Goyal NK, Teeters A, Ammerman RT. Home Visiting and Outcomes of Preterm Infants: A Systematic Review. Pediatrics. 2013 Sep;132(3):502-16.
Goyal N, Zubizarreta JR, Small DS, Lorch SA. Length of stay and readmission among late preterm infants: an instrumental variable approach. Hosp Pediatr. 2013 Jan;3(1):7-15.
Goyal NK, Fiks AG, Lorch SA. Persistence of underweight status among late preterm infants. Arch Pediatr Adolesc Med. 2012 May;166(5):424-30.
Goyal NK, Fager C, Lorch SA. Adherence to discharge guidelines for late preterm newborns. Pediatrics. 2011 Jul;128(1):62-71.
Goyal NK, Fiks AG, Lorch SA. Association of late-preterm birth with asthma in young children: practice-based study. Pediatrics. 2011 Oct;128(4):e830-8.
Crystal D. Hill, MD Attending Neonatologist, Neonatology and Pulmonary Biology
Attending Neonatologist, Neonatology and Pulmonary Biology
MD: Boonshoft School of Medicine, Wright State University, Dayton, Ohio.
Residency: Pediatrics,Nationwide Children’s Hospital, Columbus, Ohio.
Fellowship: Neonatal-Perinatal Medicine, Nationwide Children’s Hospital, Columbus, Ohio.
Steven B. Hoath, MD
Emeritus, UC Department of Pediatrics
Clinical aspects of Dr Hoath’s work derive from an understanding of the basics of human skin development and the multiple roles of the skin in neonatal care. New perspectives on the skin as a sensory interface are central to this understanding as is the role of the skin as an accessible environmental interface which complements ‘internal’ medicine. This view of the skin provides a unique, pivotal, and powerful opportunity to effect evidence-based organizational change in healthcare delivery to newborns. This approach highlights the criticality of the interface between medicine and nursing and the importance of focus on the bedside for the development of a truly “personalized” or “individualized” medicine in the future.
Epidermal barrier development (in utero and postnatal); fetal and neonatal skin adaptation (skin/environment interactions); tissue engineering of human skin (in vitro systems); innate immune function (biology of vernix and skin proteomics); development of non-invasive skin-based sensors for brain monitoring; role of the skin as a critical interface for health care delivery.
Dr. Hoath graduated from Stanford University and the University of Hamburg, Germany with majors in biology and German studies. He received his MD from the University of California, Los Angeles and completed his pediatric residency and fellowship in neonatology at UCLA before joining Cincinnati Children’s Hospital Medical Center in 1984.
He has a longstanding interest in the development of fetal and newborn skin and the multiple roles of the skin as a critical interface for healthcare delivery in the NICU. In 1994, he was one of 7 international investigators participating in the first joint effort by NASA and the National Institutes of Health to study the effect of spaceflight and zero gravity on mammalian pregnancy and fetal development. This work grounds the idea of the skin as the ‘biological spacesuit’ for the human body.
He has authored multiple papers, chapters, and a book on neonatal skin development. He is an inventor on 5 patents awarded to Cincinnati Children’s Hospital Medical Center based on the biology of the multifunctional fetal skin ‘cream’, vernix caseosa. Recent work has focused on the logico-mathematical organization of human epidermis and the close embryological connection of the skin and the brain.
Certification: American Board of Pediatrics, June 1983; Neonatal-Perinatal Medicine, November, 1983.
Adjunct Assistant Professor: Harbor UCLA Medical Center, Los Angeles, 1983.Residency: University of California, Los Angeles, 1977-79.Internship: Harbor-UCLA Medical Center, 1976-1977.MD: University of California, Los Angeles, CA, 1976.Fellowship: Neonatology, Harbor-UCLA, Los Angeles Medical Center, 1980-1982; Pathology, UCLA School of Medicine, 1973-1974.Baccalaureate: Stanford University, Biology & German Studies, 1972.
Visscher MO, Robinson M, Fugit B, Rosenberg RJ, Hoath SB, Randall Wickett R. Amputee skin condition: occlusion, stratum corneum hydration and free amino acid levels. Arch Dermatol Res. 2010 Dec 16.
Davis JA, Visscher MO, Wickett RR, Hoath SB. Influence of tumour necrosis factor-α polymorphism-308 and atopy on irritant contact dermatitis in healthcare workers. Contact Dermatitis. 2010 Dec;63(6):320-32.
Davis JA, Visscher MO, Wickett RR, Hoath SB. Role of TNF-α polymorphism -308 in neurosensory irritation. Int J Cosmet Sci. 2010 Jul 15.
Narendran V, Visscher MO, Abril I, Hendrix SW, Hoath SB. Biomarkers of epidermal innate immunity in premature and full-term infants. Pediatr Res. 2010 Apr;67(4):382-6.
Barai ND, Boyce ST, Hoath SB, Visscher MO, Kasting GB. Improved barrier function observed in cultured skin substitutes developed under anchored conditions. Skin Res Technol. 2008 Nov;14(4):418-24.
Walker VP, Akinbi HT, Meinzen-Derr J, Narendran V, Visscher M, Hoath SB. Host defense proteins on the surface of neonatal skin: implications for innate immunity. J Pediatr. 2008 Jun;152(6):777-81.
Hoath SB, Pickens WL, Visscher MO. The biology of vernix caseosa. Int J Cosmet Sci. 2006 Oct;28(5):319-33.
Spitzmiller RE, Phillips T, Meinzen-Derr J, Hoath SB. Amplitude-integrated EEG is useful in predicting neurodevelopmental outcome in full-term infants with hypoxic-ischemic encephalopathy: a meta-analysis. J Child Neurol. 2007 Sep;22(9):1069-78.
Tansirikongkol A, Hoath SB, Pickens WL, Visscher MO, Wickett RR. Equilibrium water content in native vernix and its cellular component. J Pharm Sci. 2008 Feb;97(2):985-94.
Tansirikongkol A, Wickett RR, Visscher MO, Hoath SB. Effect of vernix caseosa on the penetration of chymotryptic enzyme: potential role in epidermal barrier development. Pediatr Res. 2007 Jul;62(1):49-53.
Alan H. Jobe, MD, PhD Director, Division of Perinatal Biology
Director, Division of Perinatal Biology
Clinical trials in neonatology; bronchopulmonary dysplasia
Lung maturation and lung injury in the fetus and newborn; use of antenatal corticosteroids; lung injury with ventilation of the preterm
Moss TJM, Nitsos I, Knox CL, Polglase GR, Kallapur SG, Ikegami M, Jobe AH, Newnham JP. Ureaplasma colonization of amniotic fluid and efficacy of antenatal corticosteroids for preterm lung maturation in sheep. AJOG. 2009;200(1):96.e1-6.
Polglase GR, Hillman NH, Ball MK, Kramer BW, Kallapur SG, Jobe AH, Pillow JJ. Lung and systemic inflammation in preterm lambs on CPAP or conventional ventilation. Pediatr Res. 2009;65(1):67-71.
Cheah F-C, Pillow JJ, Kramer BW, Polglase GR, Nitsos I, Newnham JP, Jobe AH, Kallapur SG. Airway inflammatory cell responses to intra-amniotic lipopolysaccharide in a sheep model of chorioamnionitis. Am J Physiol Lung Cell Mol Physiol. 2008;296:L384-93.
Ball MK, Jobe AH, Polglase GR, Kallapur SG, Choe-Cheah F, Hillman NH, Pillow JJ. High and low body temperature during the initiation of ventilation for near-term lambs. Resuscitation. 2008;80:133-7.
Kramer BW, Albertine KH, Moss TJM, Nitsos I, Speer CP, Newnham JP, Jobe AH. All-trans retinoic acid does not modulate intra-amniotic endotoxin mediated effects on the fetal sheep lung. The Anatomical Record. 2008;291:1271-7.
Polglase GR, Hillman NH, Pillow JJ, Cheah F-C, Nitsos I, Moss TJ, Kramer BW, Ikegami M, Kallapur SG, Jobe AH. Positive end-expiratory pressure and tidal volume during initial ventilation of preterm lambs. Pediatr Res. 2008;64:517.
Hillman N, Moss TJM, Nitsos I, Kramer BW, Bachurski C, Ikegami M, Jobe AH, Kallapur SG. Toll-like receptors and agonist responses in the developing fetal sheep lung. Pediatr Res. 2008;63:388-93.
Sweet DG, Huggett MT, Warner JA, Moss TJM, Halliday HL, Newnham JP, Kallapur SG, Jobe AH, Kramer BW. Maternal betamethasone and chorioamnionitis induce different collagenases and lung maturation in fetal sheep lungs. Neonatology. 2008;94:79-86.
Jobe AH, Moss TJM, Nitsos Il, Ikegami M, Kallapur SG, Newnham JP. Betamethasone for lung maturation: testing dose and formulation in fetal sheep. AJOG. 2007;197:523.
Moss TJM, Knox CL, Kallapur SG, Nitsos I, Theodoropoulos C, Ikegami M, Newnham JP, Jobe AH. Experimental amniotic fluid infection in sheep: effects of Ureaplasma parvum serovars 3 and 6 on preterm or term fetal sheep. Am J Ob Gyn. 2008;198:122e18.
Beth Ann Johnson, MD, MA Attending Neonatologist, Neonatology and Pulmonary Biology
Cardiac intensive care; neonatology; premature infants with congenital heart disease; mechanical assist devices; fetal diagnosis; ethics
Suhas G. Kallapur, MD Director, Neonatology Continuing Medical Education
Director, Neonatology Continuing Medical Education
Chorioamnionitis; bronchopulmonary dysplasia; respiratory distress syndrome; fetal immunity
Kemp MW, Kallapur SG, Jobe AH, Newnham JP. Obesity and the developmental origins of health and disease. J Paediatr Child Health. 2011 Jan 18.
Morrow AL, Meinzen-Derr J, Huang P, Schibler KR, Cahill T, Keddache M, Kallapur SG, Newburg DS, Tabangin M, Warner BB, Jiang X. Fucosyltransferase 2 Non-Secretor and Low Secretor Status Predicts Severe Outcomes in Premature Infants. J Pediatr. 2011 May;158(5):745-51.
Hillman NH, Kallapur SG, Pillow JJ, Nitsos I, Polglase GR, Ikegami M, Jobe AH. Inhibitors of inflammation and endogenous surfactant pool size as modulators of lung injury with initiation of ventilation in preterm sheep. Respir Res. 2010 Oct 29;11:151.
Shah TA, Hillman NH, Nitsos I, Polglase GR, Pillow JJ, Newnham JP, Jobe AH, Kallapur SG. Pulmonary and systemic expression of monocyte chemotactic proteins in preterm sheep fetuses exposed to lipopolysaccharide-induced chorioamnionitis. Pediatr Res. 2010 Sep;68(3):210-5.
Shah TA, Hillman NH, Nitsos I, Polglase GR, Pillow JJ, Newnham JP, Jobe AH, Kallapur SG. Pulmonary and Systemic Expression of Monocyte Chemotactic Proteins in Preterm Sheep Fetuses Exposed to LPS Induced Chorioamnionitis. Pediatr Res. 2010 May 28.
Jobe AH, Kallapur SG. Long term consequences of oxygen therapy in the neonatal period. Semin Fetal Neonatal Med. 2010 Aug;15(4):230-5.
Hillman NH, Pillow JJ, Ball MK, Polglase GR, Kallapur SG, Jobe AH. Antenatal and postnatal corticosteroid and resuscitation induced lung injury in preterm sheep. Respir Res. 2009 Dec 15;10:124.
Hillman NH, Kallapur SG, Pillow JJ, Moss TJ, Polglase GR, Nitsos I, Jobe AH. Airway injury from initiating ventilation in preterm sheep. Pediatr Res. 2010 Jan;67(1):60-5.
Jobe AH, Nitsos I, Pillow JJ, Polglase GR, Kallapur SG, Newnham JP. Betamethasone dose and formulation for induced lung maturation in fetal sheep. Am J Obstet Gynecol. 2009 Dec;201(6):611.e1-7.
Kallapur SG, Moss TJ, Auten RL Jr, Nitsos I, Pillow JJ, Kramer BW, Maeda DY, Newnham JP, Ikegami M, Jobe AH. IL-8 signaling does not mediate intra-amniotic LPS-induced inflammation and maturation in preterm fetal lamb lung. Am J Physiol Lung Cell Mol Physiol. 2009 Sep;297(3):L512-9.
Beena D. Kamath-Rayne, MD, MPH Attending Neonatologist, Neonatology and Pulmonary Biology
Perinatal epidemiology and public health; global health
Dr. Kamath-Rayne is doing collaborative research with maternal-fetal medicine on preterm birth, fetal lung maturity, and biomarker discovery in amniotic fluid. She has received a BIRCWH K12 award to fund this research. She has published on neonatal outcomes after elective Cesarean section, and after documented fetal lung maturity. Her work was required reading for the Maintenance for Certification for the American Board of Obstetrics and Gynecology in 2010.
Dr. Kamath-Rayne was a reviewer for the Helping Babies Breathe (HBB) global neonatal resuscitation curriculum, and is currently a Master Trainer. She is collaborating on several studies of HBB around the world. With Dr. Alan Jobe, she is also a neonatal consultant for MANDATE (Maternal and Neonatal Directed Assessment of Technology), a project funded by the Bill and Melinda Gates Foundation to RTI International to inform the development of technologies to decrease maternal and neonatal mortality worldwide.
Kamath-Rayne BD, DeFranco EA, Marcotte MP. Antenatal steroids for treatment of fetal lung immaturity after 34 weeks of gestation: an evaluation of neonatal outcomes. Obstet Gynecol. 2012; 119(5): 909-916.
Kamath-Rayne BD, MacGuire ER, McClure EM, Goldenberg RL, Jobe AH. Clinical algorithms for identification of sick newborns in community-based settings. Acta Paediatr. 2012; 101: 344-351.
Kamath BD, Donovan EF, Christopher R, Brodbeck J, Slone C, Marcotte MP. Using improvement science to increase accuracy and reliability of gestational age documentation. Am J of Perinatol. 2012; 29(3): 217-223.
Kamath BD, Marcotte, MP, DeFranco, EA. Neonatal morbidity after documented fetal lung maturity in late preterm and early term infants. Am J Obstet Gynecol. 2011; 204: 518.e1-e8.
Goldenberg RL, McClure EM, MacGuire ER, Kamath BD, Jobe AH. Lessons for low-income regions following the reduction in hypertension-related maternal mortality in high-income countries. Int J Gynecol Obstet. 2011; 113(2):91-5.
Kamath BD, MacGuire ER, McClure EM, Goldenberg RL, Jobe AH. Neonatal mortality from respiratory distress syndrome: a historical review with lessons for low-resource countries. Pediatrics. 2011; 127(6):1139-46.
Kamath BD, Fashaw L, Kinsella JP. Adrenal insufficiency in newborns with congenital diaphragmatic hernia. J Pediatr. 2010; 156(3):495-497.
Kamath BD, Todd JK, Glazner JE, Lezotte D, Lynch AM. Neonatal outcomes after elective Cesarean section. Obstetr Gynecol. 2009; 113(6): 1231-1238. *Required reading for Maintenance of Certification for American Board of Obstetrics and Gynecology, 2010
Kamath BD, Box TL, Simpson M, Hernández J. Infants born at the threshold of viability in relation to neonatal mortality: Colorado, 1991 to 2003. J Perinatol. 2008; 28(5): 354-360.
Jobe AH, Kamath-Rayne BD. Fetal lung development and surfactant. In: Creasy and Resnik’s Maternal-Fetal Medicine: Principles and Practice. Greene MF, Creasy RK, Resnik R, Iams JD, Lockwood CJ, Moore T (Eds.). 2012.
Heather C. Kaplan, MD, MSCE Attending Neonatologist, Neonatology and Pulmonary Biology
Heather Kaplan conducts research focusing on understanding variations in evidence-based care practices across hospitals and examining strategies for increasing the implementation of evidence into practice in perinatal care. She uses a systems lens to understand and ultimately change behavior at the individual, group, organizational, and environmental levels of the health care system.
Kaplan HC, Lannon C, Walsh MC, Donovan EF; Ohio Perinatal Quality Collaborative. Ohio statewide quality-improvement collaborative to reduce late-onset sepsis in preterm infants. Pediatrics. 2011 Mar;127(3):427-35.
Kaplan HC, Lorch SA, Pinto-Martin J, Putt M, Silber JH. Assessment of surfactant use in preterm infants as a marker of neonatal intensive care unit quality. BMC Health Serv Res. 2011 Jan 31;11:22.
Kaplan HC, Brady PW, Dritz MC, Hooper DK, Linam WM, Froehle CM, Margolis P. The influence of context on quality improvement success in health care: a systematic review of the literature. Milbank Q. 2010 Dec;88(4):500-59.
Kaplan, HC, Tabangin ME, McClendon D, Meinzen-Derr J, Margolis PA, Donovan EF. Understanding Variation in Vitamin A Supplementation Among NICUs. Pediatrics. 2010 Aug;126(2):e367-73.
Alan P. Kenny, MD, PhD
Instructor, UC Department of Pediatrics
Neonatal care; neonatal lung disease; neonatal malformations and anomalies
Lung progenitor development; stem cell differentiation; fetal malformations
Kenny AP, Crimmins NA, Mackay DJ, Hopkin RJ, Bove KE, Leonis MA. Concurrent course of transient neonatal diabetes with cholestasis and paucity of interlobular bile ducts: a case report. Pediatr Dev Pathol. 2009 Sep-Oct;12(5):417-20.Li Y, Rankin SA, Sinner D, Kenny AP, Krieg PA, Zorn AM. Sfrp5 coordinates foregut specification and morphogenesis by antagonizing both canonical and noncanonical Wnt11 signaling. Genes Dev. 2008 Nov 1;22(21):3050-63.
Kenny A. Vitamin A for prevention of bronchopulmonary dysplasia. Preemie Press. Local news brief for Good Samaritan Hospital. 2007.
Angerer LM, Kenny AP, Newman LA, Angerer RC. Mutual antagonism of SoxB1 and canonical Wnt signaling in sea urchin embryos. Signal Transduction Wiley Interscience, New York. 2007 7(2), 174-178.
Jennifer McAllister, MD Staff Physician, Neonatology and Pulmonary Medicine
Staff Physician, Neonatology and Pulmonary Medicine
MD: University of Toledo College of Medicine, Toledo, OH, 2007.
Residency: Pediatrics, University of Michigan Mott Children's Hospital, Ann Arbor, MI, 2010.
Certification: Pediatrics, 2010.
Alisa O. McGill, MD Staff Physician, Neonatology
Kristin R. Melton, MD Associate Program Director, Neonatal-Perinatal Medicine Fellowship
Associate Program Director, Neonatal-Perinatal Medicine Fellowship
Craniofacial malformations; somitogenesis
Craniofacial defects are an important cause of morbidity for children worldwide, with craniofacial defects making up one third of all congenital anomalies and occurring in association with over 100 different genetic syndromes. Cranial neural crest cells are multipotent, migratory cells that form most of the bone, cartilage, connective tissue and peripheral nervous system of the head and face. Craniofacial defects are largely attributed to abnormalities in the formation, migration or differentiation of the neural crest. The cranial neural crest is responsive to the tissues that surround it, however, so craniofacial defects may result from a primary defect in neural crest cells, or from a defect in the tissues that signal to neural crest.
Kristin Melton, MD, has an interest in studying the tissues that signal to the neural crest, such as the endothelium and cranial mesoderm, and the signaling pathways utilized by these tissues. Using embryo culture techniques, cell culture and transgenic mouse models, Dr. Melton is investigating the interaction between the endothelium and the neural crest. Microarray has also been used to identify a number of mesoderm-specific genes that may play key roles in craniofacial development.
Dr. Melton is a practicing neonatologist and attends at the RCNIC in Cincinnati Children’s Hospital. Her clinical interests include newborns with complex congenital anomalies and genetic defects, as well as a focus on family-centered care.
Gibb S, Zagorska A, Melton K, Tenin G, Vacca I, Trainor P, Maroto M, Dale JK. Interfering with Wnt signalling alters the periodicity of the segmentation clock. Dev Biol. 2009 Jun 1;330(1):21-31.
Nesslein LL, Melton KR, Ikegami M, Na CL, Wert SE, Rice WR, Whitsett JA, Weaver TE. Partial SP-B deficiency perturbs lung function and causes air space abnormalities. Am J Physiol Lung Cell Mol Physiol. 2005 Jun;288(6):L1154-61.
Melton KR, Nesslein LL, Ikegami M, Tichelaar JW, Clark JC, Whitsett JA, Weaver TE. SP-B deficiency causes respiratory failure in adult mice. Am J Physiol Lung Cell Mol Physiol. 2003 Sep;285(3):L543-9.
Melton K, Akinbi HT. Neonatal jaundice. Strategies to reduce bilirubin-induced complications. Postgrad Med. 1999 Nov;106(6):167-8, 171-4, 177-8.
Nagendra K. Monangi, MD Attending Neonatologist
Maternal / infant nutrition; vitamin D
MBBS: Andhra Medical College, Visakhapatnam, India, 2001.
Post Graduate Diploma: Pediatrics, Osmania Medical College, Hyderabad, India, 2005.
Residency: Pediatrics, University of South Alabama, Mobile, AL, 2009.
Fellwoship: Neonatal-Perinatal Medicine, Cincinnati Children’s Hospital Medical Center / University of Cincinnati, Cincinnati, OH, 2012.
Certification: Pediatrics, 2009; Neonatology, Board Eligible.
Laurel B. Moyer, MD Medical Director, TriHealth Nurseries
Medical Director, TriHealth Nurseries
Chair, Neonatal Pediatrics
Quality improvement; global health
Vivek Narendran, MD, MRCP, MBA Medical Director, University of Cincinnati Medical Center NICU
Medical Director, University of Cincinnati Medical Center NICU
Medical Director, Cincinnati Perinatal Outreach Project
Director, Neonatal Intensive Care Unit and Newborn Services, Christ Hospital
Non-Invasive Ventilation of the Preterm Infant, Business Case for Quality Improvements
Interested in innate immunity of the skin with a particular focus on epidermal biomarkers and antimicrobial peptides on the skin surface
Binder S, Hill K, Meinzen-Derr J, Greenberg JM, Narendran V. Increasing VLBW Deliveries at Subspecialty Perinatal Centers via Perinatal Outreach. Pediatrics. 2011 Feb 14.
Sampath V, Narendran V, Donovan EF, Stanek J, Schleiss MR. Nonimmune hydrops fetalis and fulminant fatal disease due to congenital cytomegalovirus infection in a premature infant. J Perinatol. 2005 Sep;25(9):608-11.
Visscher MO, Narendran V, Pickens WL, LaRuffa AA, Meinzen-Derr J, Allen K, Hoath SB. Vernix caseosa in neonatal adaptation. J Perinatol. 2005 Jul;25(7):440-6. Review.
Akinbi HT, Narendran V, Pass AK, Markart P, Hoath SB. Host defense proteins in vernix caseosa and amniotic fluid. Am J Obstet Gynecol. 2004 Dec;191(6):2090-6.
Narendran V, Donovan EF, Hoath SB, Akinbi HT, Steichen JJ, Jobe AH. Early bubble CPAP and outcomes in ELBW preterm infants. J Perinatol. 2003 Apr-May;23(3):195-9.
Hoath SB, Narendran V. Adhesives and emollients in the preterm infant. Semin Neonatol. 2000 Nov;5(4):289-96. Review.
Narendran V, Wickett RR, Pickens WL, Hoath SB. Interaction between pulmonary surfactant and vernix: a potential mechanism for induction of amniotic fluid turbidity. Pediatr Res. 2000 Jul;48(1):120-4.
Amy T. Nathan, MD Medical Director, Neonatology
Medical Director, Neonatology
necrotizing enterocolitis; quality improvement; neonatal immune responses; family-centered care
Immune modulation of lung injury and inflammation
Innate immune responses at the epithelial boundaries in preterm infants (lung, intestine) can be protective, but inflammatory responses may also cause significant damage. Necrotizing enterocolitis is a devastating, multi-factorial disease marked by intense inflammation, which may be related to changes in the intestinal microbiome combined with compromised perfusion. Dr. Nathan focuses on antecedent factors leading to necrotizing enterocolitis, and is interested in applying quality improvement methods to reduce the incidence of this major morbidity in preterm infants.
Wills-Karp M, Nathan A, Page K, Karp CL. New insights into innate immune mechanisms underlying allergenicity. Mucosal Immunol. 2010 Mar;3(2):104-10.
Nathan AT, Peterson EA, Chakir J, Wills-Karp M. Innate immune responses of airway epithelium to house dust mite are mediated through beta-glucan-dependent pathways. J Allergy Clin Immunol. 2009 Mar;123(3):612-8.
Chavez-Valdez R, Ahlawat R, Wills-Karp M, Nathan AT, Ezell T, and Gauda EB. Correlation between serum caffeine levels and changes in cytokine profile in a cohort of preterm infants. J Peds. Aug 5 2010.
Wexelblatt, SL, Greenberg, JM, and Nathan AT. Regional care model enables rapid response to adverse drug events. J Perintatol. 2010 30: 300-2.
Chavez-Valdez R, Wills-Karp M, Ahlawat R, Cristofalo EA, Nathan AT, and Gauda EB. Caffeine modulates TNF- production by cord blood monocytes; the role of adenosine receptors. Ped Research. 2009 65(2):203-8. Wendel KR, Nathan AT. Inhaled nitric oxide. Newborn and Infant Nursing Reviews. 2006 6(2):100-105.
Danna M. Premer, MD Attending Neonatologist
John H. Reuter, MD, PhD Attending Neonatologist
Chair, Department of Pediatrics at Bethesda North Hospital Nurseries
MD: University of Cincinnati College of Medicine, Cincinnati, Ohio, 1976.PhD: Physiology, University of Cincinnati College of Medicine, 1973.
Residency: Pediatrics, University of Cincinnati and Children's Hospital Medical Center, Cincinnati, Ohio, 1978.
Fellowship: Moffitt Hospital, Cardiovascular Research Institute, University of California at San Francisco, San Francisco, Calif., 1980.
Certifications: Pediatrics, 1982 Neonatal; Perinatal Medicine, 1983.
Ward R. Rice, MD, PhD Medical Director, Newborn Services, St. Elizabeth Medical Center
Medical Director, Newborn Services, St. Elizabeth Medical Center
Director, Neonatology Fellowship Training Program
Hypotension in ELBW infants; EMR
Processing of Surfactant Protein C
Ward R. Rice, MD, PhD, is the Director of the Neonatology Fellowship Training Program and Director of Newborn Services, St. Elizabeth Medical Center.
Dr. Rice received MD and PhD degrees from the University of Chicago and has been on the faculty since 1983. He has been the Director of the Neonatology Fellowship Training Program since 1990. During this time, he has supervised the clinical training of more than 100 fellows who currently hold academic appointments across the United States and around the world.
His past NIH supported research accomplishments included identification of novel G-protein coupled receptors on alveolar type II cells and studies of the interaction of the opportunistic pathogen P carinii with alveolar type II cells. He currently works in collaboration with Dr. Timothy Weaver to study biosynthesis of Surfactant Protein C.
PhD: 1972-76 University of Chicago, Chicago, Illinois.
PhD: Biochemistry, Thesis Advisor: T.L. Steck, MD, Thesis: "Pyruvate Flux Across The Isolated Human Erythrocyte Membrane"
MD: 1972-78 University of Chicago, Chicago, Illinois.
Internship: 1978-79 Duke University Medical Center, Durham, North Carolina.
Residency: 1979-81 Duke University Medical Center, Durham, North Carolina.
Fellowship Neonatology: 1981-83 University of Cincinnati College of Medicine, Children's Hospital Medical Center.
Certification: Pediatrics, 1983; Sub-board Neonatal-Perinatal Medicine, 1983.
Conkright JJ, Apsley KS, Martin EP, Ridsdale R, Rice WR, Na CL, Yang B, Weaver TE. Nedd4-2-mediated ubiquitination facilitates processing of surfactant protein-C. Am J Respir Cell Mol Biol. 2010 Feb;42(2):181-9.
Rice WR, Conkright JJ, Na CL, Ikegami M, Shannon JM, Weaver TE. Maintenance of the mouse type II cell phenotype in vitro. Am J Physiol Lung Cell Mol Physiol. 2002 Aug;283(2):L256-64.
Huffman Reed JA, Rice WR, Zsengellér ZK, Wert SE, Dranoff G, Whitsett JA. GM-CSF enhances lung growth and causes alveolar type II epithelial cell hyperplasia in transgenic mice. Am J Physiol. 1997 Oct;273(4 Pt 1):L715-25.
Rice W, Shannon JM, Burton F, Fiedeldey D. Expression of a brain-type cannabinoid receptor (CB1) in alveolar Type II cells in the lung: regulation by hydrocortisone. Eur J Pharmacol. 1997 May 30;327(2-3):227-32.
Linke MJ, Burton FM, Fiedeldey DT, Rice WR. Surfactant phospholipid secretion from rat alveolar type II cells: possible role of PKC isozymes. Am J Physiol. 1997 Feb;272(2 Pt 1):L171-7.
Chroneos ZC, Abdolrasulnia R, Whitsett JA, Rice WR, Shepherd VL. Purification of a cell-surface receptor for surfactant protein A. J Biol Chem. 1996 Jul 5;271(27):16375-83.
Haas M, Rice WR. Respiratory distress syndrome for the practicing pediatrician. Pediatr Ann. 1995 Nov;24(11):572-6, 579-80. Review.
Rice WR, Burton FM, Fiedeldey DT. Cloning and expression of the alveolar type II cell P2u-purinergic receptor. Am J Respir Cell Mol Biol. 1995 Jan;12(1):27-32.
Rice WR, Singleton FM, Linke MJ, Walzer PD. Regulation of surfactant phosphatidylcholine secretion from alveolar type II cells during Pneumocystis carinii pneumonia in the rat. JClin Invest. 1993 Dec;92(6):2778-82.
Jerod M. Rone, MD Medical Director, Kettering Medical Center NICU
Medical Director, Kettering Medical Center NICU
MD: Wright State University School of Medicine, Dayton, OH, 1991.
Residency: Pediatrics, Wright State University School of Medicine, Dayton Children’s Medical Center, Dayton, OH, 1995.
Fellowship: Neonatal-Perinatal Medicine, University of Cincinnati, CCHMC, Cincinnati, OH, 1998.
Certification: Neonatal-Perinatal Medicine, 1999.
Deborah K. Rufner, MD Staff Physician, Neonatology
MD: The Ohio State University, Columbus, OH, 1975.
Residency: Naval Regional Medical Center, San Diego, CA, 1978.
Certification: American Board of Pediatrics, 1980.
Kurt R. Schibler, MD Director, Neonatology Clinical Research Program