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The Perinatal Institute at Cincinnati Children's is home to specialists with a variety of backgrounds and areas of focus. As a team, this diversity makes us better prepared to care for your child's unique needs.
James M. Greenberg, MD Co-Director, Perinatal Institute
Co-Director, Perinatal Institute
Director, Division of Neonatology
Professor, UC Department of Pediatrics
Neonatal chronic lung disease; late preterm infant
Binder S, Hill K, Meinzen-Derr J, Greenberg JM, Narendran V. Increasing VLBW Deliveries at Subspecialty Perinatal Centers via Perinatal Outreach. Pediatrics. 2011 Mar;127(3):487-93.
Kulkarni RM, Herman A, Ikegami M, Greenberg JM, Akeson AL. Lymphatic ontogeny and effect of hypoplasia in developing lung. Mech Dev. 2011 Jan-Feb;128(1-2):29-40. Kulkarni RM, Greenberg JM, Akeson AL. NFATc1 regulates lymphatic endothelial development. Mech Dev. 2009 May-Jun;126(5-6):350-65.
Mallory BP, Mead TJ, Wiginton DA, Kulkarni RM, Greenberg JM, Akeson AL. Lymphangiogenesis in the developing lung promoted by VEGF-A. Microvasc Res. 2006 Jul-Sep;72(1-2):62-73.
Preciado DA, Rutter MJ, Greenberg JM, Bahado-Singh R, Lambers D, Willging JP. Intrapartum management of severe fetal airway obstruction. J Otolaryngol. 2004 Oct;33(5):283-8.
Akeson AL, Cameron JE, Le Cras TD, Whitsett JA, Greenberg JM. Vascular endothelial growth factor-A induces prenatal neovascularization and alters bronchial development in mice. Pediatr Res. 2005 Jan;57(1):82-8.
Greenberg JM, Thompson FY, Brooks SK, Shannon JM, Akeson AL. Slit and robo expression in the developing mouse lung. Dev Dyn. 2004 Jun;230(2):350-60.
Le Cras TD, Spitzmiller RE, Albertine KH, Greenberg JM, Whitsett JA, Akeson AL. VEGF causes pulmonary hemorrhage, hemosiderosis, and air space enlargement in neonatal mice. Am J Physiol Lung Cell Mol Physiol. 2004 Jul;287(1):L134-42.
Akeson AL, Greenberg JM, Cameron JE, Thompson FY, Brooks SK, Wiginton D, Whitsett JA. Temporal and spatial regulation of VEGF-A controls vascular patterning in the embryonic lung. Dev Biol. 2003 Dec 15;264(2):443-55.
Greenberg JM, Thompson FY, Brooks SK, Shannon JM, McCormick-Shannon K, Cameron JE, Mallory BP, Akeson AL. Mesenchymal expression of vascular endothelial growth factors D and A defines vascular patterning in developing lung. Dev Dyn. 2002 Jun;224(2):144-53.
Louis J. Muglia, MD, PhD Co-Director, Perinatal Institute, Division of Neonatology
Co-Director, Perinatal Institute, Division of Neonatology
Director, Center for Prevention of Preterm Birth
Visit the Muglia Lab
Dr. Muglia has pioneered the in vivo analyses of regulation of the endocrine stress response and the molecular pathways leading to birth using novel genetically altered mutant mice. These studies have elucidated the importance of corticotropin-releasing hormone, glucocorticoids, and prostaglandins in neuroendocrine modulation, behavior, and perinatal adaptation. These studies have evolved over the last decade to specifically focus on the mechanisms controlling the timing for birth in humans using genetics and comparative genomics. The composition of the biological clock metering the duration of human gestation remains a central question in reproductive biology. The goal of the Muglia laboratory is to understand the molecular timing machinery comprising this biological clock to prevent or better treat human preterm labor and delivery.
Among Dr. Muglia’s achievements are more than 150 publications and many awards, including a Burroughs Wellcome Fund Career Development Award in the Biomedical Sciences, the Society of Pediatric Research Young Investigator Award, and election to the American Society for Clinical Investigation. In 2010, Dr. Muglia was elected to Fellow in the American Association for the advancement of Science. He is an active member of the Society for Pediatric Research, Society for Neuroscience, and the Lawson Wilkins Pediatric Endocrine Society. Dr. Muglia currently serves as chair of the Board of Scientific Counselors for the Eunice Kennedy Shriver National Institute of Child Health and Human Development of the National Institutes of Health.
BS: University of Michigan, Ann Arbor, MI, 1981.
PhD: University of Chicago, Chicago, IL, 1986.
MD: University of Chicago, Chicago, IL, 1988.
Muglia LJ, Jacobson L, Dikkes P, Majzoub JA. Corticotropin-releasing hormone deficiency reveals major fetal but not adult glucocorticoid need. Nature. 1995; 373:427-432.
Gross G, Imamura T, Luedke C, Vogt SK, Olson LM, Nelson DM, Sadovsky Y, Muglia LJ. Opposing actions of prostaglandins and oxytocin determine the onset of murine labor. Proc. Natl. Acad. Sci. USA. 1998; 95: 11871-11875.
Bethin KE, Nagai Y, Sladek R, Asada M, Sadovsky Y, Hudson TJ, Muglia LJ. Microarray analysis of uterine gene expression in mouse and human pregnancy. Mol Endocrinol. 2003; 17: 1454-1469.
Kistka Z A-F, Palomar P, Lee KA, Boslaugh SE, Wangler MF, Cole FS, DeBaun MR, Muglia LJ. Racial disparity in the frequency of recurrence of preterm birth. Am J Obstet Gynecol. 2007; 196: 131.e1-131.e6.
Roizen J, Asada M, Tong M, Tai H-H, Muglia LJ. Preterm birth without progesterone withdrawal in 15-hydroxyprostaglandin dehydrogenase hypomorphic mice. Mol Endocrinol. 2008; 22: 105-112.
Kolber BJ, Roberts MS, Howell MP, Wozniak DF, Sands MS, Muglia LJ. Central amygdala glucocorticoid receptor action promotes fear-associated CRH activation and conditioning. Proc Natl Acad Sci USA. 2008; 105: 12004 - 12009.
Plunkett J, Feitosa MF, Trusgnich M, Wangler MF, Palomar L, Kistka ZA-F, DeFranco EA, Shen TT, Stormo EAD, Puttonen H, Hallman M, Haataja R, Luukkonen A, Fellman V, Peltonen L, Palotie A, Daw EW, An P, Teramo K, Borecki I, Muglia LJ. Mother’s genome or maternally-inherited genes acting in the fetus influence gestational age in familial preterm birth. Human Heredity. 2009; 68: 209-219.
Kolber BJ, Boyle MP, Wieczorek L, Kelley CL, Kelley CL, Onwuzurike CC, Nettles SA, Vogt SK, Muglia LJ. Transient early-life forebrain corticotropin-releasing hormone elevation causes long-lasting anxiogenic and despair-like changes in mice. J Neurosci. 2010; 30: 2571-2581.
Muglia LJ, Katz M. The enigma of spontaneous preterm birth. N Engl J Med. 2010; 362: 529-535.
Plunkett J, Doniger S, Orabona G, Morgan T, Haataja R, Hallman M, Puttonen H, Menon R, Kuczynski E, Norwitz E, Victoria Snegovskikh V, Palotie A, Peltonen L, Fellman V, DeFranco EA, Chaudhari BP, McGregor TL, McElroy JJ, Oetjens MT, Teramo K, Boreck I, Fay J, Muglia L. An evolutionary genomic approach to identify genes involved in human birth timing. PLoS Genetics. 2011; 7: e1001365.
Muglia. Amygdala Glucocorticoid Receptor Function in Stress. Principle Investigator. NIH/NIMH. Feb 2009 - Dec 2013.
Genetic Analysis of Human Preterm Birth. Principle Investigator. March of Dimes. Mar 2005 - Feb 2014.
Burroughs Wellcome Fund Research Consortium on Preterm Birth. Program Director. Burroughs Wellcome Fund. Oct 2007 - Sep 2014.
Herzog. Cellular Basis of Circadian Rhythms in Mammals. Co-Investigator. NIH/NIMH. Apr 2009 - Mar 2014.
Winder. Alcohol Action on Extended Amygdala Glutamate Synapses. Co-Investigator. NIH/NIAAA. Jul 2010 - Apr 2015.
Jeffrey A. Whitsett, MD Co-Director, Perinatal Institute
Chief, Section of Neonatology, Perinatal and Pulmonary Biology
Cystic fibrosis research; lung morphogenesis; control of gene expression in the respiratory epithelium; gene delivery and therapy
Visit the Whitsett Lab.
Jeffrey A. Whitsett, MD, is chief of the Section of Neonatology, Perinatal and Pulmonary Biology at Cincinnati Children's Hospital Medical Center.
Dr. Whitsett received his medical degree from Columbia University, in New York, and has been a faculty member since 1977. He is internationally known for his research in pulmonary medicine, as well as for his clinical expertise in neonatology.
Dr. Whitsett has made a series of groundbreaking contributions in pulmonary medicine. His major pioneering work has been on surfactant proteins A, B, C and D, cloning their genes, and clarifying their roles in lung development.
Throughout his career, Dr. Whitsett has had the remarkable ability to move from molecular biology, to animal models, to diagnosis and therapy of human disease. He played a critical role in making surfactant protein replacement a routine tool for treating immature lungs and respiratory distress syndrome in premature infants. His laboratory has contributed to the identification of a number of genes critical for lung formation and function. Mutations in genes regulating surfactant homeostasis were shown to cause acute and chronic lung disease in infants and adults.
Dr. Whitsett is a member of the Institute of Medicine, National Academy of Sciences and is the recipient of the Mead Johnson Award, a National Institutes of Health (NIH) Merit Award, the first Julius Comroe Lectureship in Pulmonary Research from FASEB, the William Cooper Procter Award from Cincinnati Children's, the Amberson Lecture Award of the American Thoracic Society, the prestigious Daniel Drake Medal for scientific contributions from the University of Cincinnati College of Medicine, the International Arvo Ylppö Medal from the Finnish Foundation for Pediatric Research and the Grand Hamdan International Award on Neonatal Medicine from the United Arab Emirates.
Dr. Whitsett is the author of more than 400 papers in both the basic science and clinical literature.
MD: Columbia University, New York, NY, 1973.
Residency: Pediatrics, Mt. Sinai Hospital, New York City, 1974 to 1976.
Fellowship: Neonatology, Children's Hospital Medical Center, University of Cincinnati College of Medicine, 1976 to 1977.
Sivaprasad U, Askew DJ, Ericksen MB, Gibson AM, Stier MT, Brandt EB, Bass SA, Daines MO, Chakir J, Stringer KF, Wert SE, Whitsett JA, Le Cras TD, Wills-Karp M, Silverman GA, Khurana Hershey GK. A nonredundant role for mouse Serpinb3a in the induction of mucus production in asthma. J Allergy Clin Immunol. 2011 Jan;127(1):254-61, 261.e1-6. Lin SC, Wani MA, Whitsett JA, Wells JM. Klf5 regulates lineage formation in the pre-implantation mouse embryo. Development. 2010 Dec;137(23):3953-63. Suzuki T, Sakagami T, Young LR, Carey BC, Wood RE, Luisetti M, Wert SE, Rubin BK, Kevill K, Chalk C, Whitsett JA, Stevens C, Nogee LM, Campo I, Trapnell BC. Hereditary pulmonary alveolar proteinosis: pathogenesis, presentation, diagnosis, and therapy. Am J Respir Crit Care Med. 2010 Nov 15;182(10):1292-304. Wang IC, Zhang Y, Snyder J, Sutherland MJ, Burhans MS, Shannon JM, Park HJ, Whitsett JA, Kalinichenko VV. Increased expression of FoxM1 transcription factor in respiratory epithelium inhibits lung sacculation and causes Clara cell hyperplasia. Dev Biol. 2010 Nov 15;347(2):301-14. Perl AK, Riethmacher D, Whitsett JA. Conditional Depletion of Airway Progenitor Cells Induces Peribronchiolar Fibrosis. Am J Respir Crit Care Med. 2010 Sep 24.
Tompkins DH, Besnard V, Lange AW, Keiser AR, Wert SE, Bruno MD, Whitsett JA. Sox2 Activates Cell Proliferation and Differentiation in the Respiratory Epithelium. Am J Respir Cell Mol Biol. 2010 Sep 20. Meyer SE, Hasenstein JR, Baktula A, Velu CS, Xu Y, Wan H, Whitsett JA, Gilks CB, Grimes HL. Kruppel-like factor 5 is not required for K-RasG12D lung tumorigenesis, but represses ABCG2 expression and is associated with better disease-specific survival. Am J Pathol. 2010 Sep;177(3):1503-13. Xu Y, Zhang M, Wang Y, Kadambi P, Dave V, Lu LJ, Whitsett JA. A systems approach to mapping transcriptional networks controlling surfactant homeostasis. BMC Genomics. 2010 Jul 26;11:451. Sakagami T, Beck D, Uchida K, Suzuki T, Carey BC, Nakata K, Keller G, Wood RE, Wert SE, Ikegami M, Whitsett JA, Luisetti M, Davies S, Krischer JP, Brody A, Ryckman F, Trapnell BC. Patient-derived granulocyte/macrophage colony-stimulating factor autoantibodies reproduce pulmonary alveolar proteinosis in nonhuman primates. Am J Respir Crit Care Med. 2010 Jul 1;182(1):49-61. Chen G, Wan H, Luo F, Zhang L, Xu Y, Lewkowich I, Wills-Karp M, Whitsett JA. Foxa2 programs Th2 cell-mediated innate immunity in the developing lung. J Immunol. 2010 Jun 1;184(11):6133-41.
Sheela Rath Geraghty, MD, MS, IBCLC, FAAP Medical Director, Center for Breastfeeding Medicine
Medical Director, Center for Breastfeeding Medicine
Associate Professor, UC Department of Pediatrics
Sheela R. Geraghty, MD, is a general pediatrician and lactation consultant. Dr. Geraghty is the medical director for the Cincinnati Children’s Center for Breastfeeding Medicine. Dr. Geraghty’s research and clinical practice focuses on barriers to successful breastfeeding.
Geraghty SR, Saluja K, Merchant M. Breastfeeding Disparities: Challenges and Solutions. Infant, Child, & Adolescent Nutrition. 2012;4(4):207-214.
Geraghty SR, Sucharew H, Rasmussen KM. Trends in breastfeeding; It’s not only at the breast any more. Maternal and Child Nutrition. 2012. Epub ahead of print.
Martin MA, Lassek WD, Gaulin SJ, Evans RE, Woo JG, Geraghty SR, Davidson BS, Morrow AL, Kaplan HS, Gurven MD. Fatty acid composition in the mature milk of Bolivian forager-horticulturalists: comparisons with a U.S. sample. Maternal and Child Nutrition. 2012;8(3):404-418.
Geraghty SR, Tabangin ME, Davidson BS, Morrow AL. Predictors of Breast Milk Expression by One Month Postpartum and Influence on Breast Milk Feeding Duration. Breastfeeding Medicine. 2012;7(2):112-7.
Rasmussen KM, Geraghty SR. The quiet revolution: Breastfeeding transformed with the use of breast pumps. The American Journal of Public Health. 2011;101(8):1356-9.
Geraghty SR, Heier JE, Rasmussen KM. Got Milk? Sharing human milk via the internet. Public Health Reports. 2011;126(2):161-164.
Leonard SA, Labiner-Wolfe J, Geraghty SR, Rasmussen KM. Associations among high prepregnancy body mass index, breast milk expression, and breast milk production and feeding. The American Journal of Clinical Nutrition. 2011 Mar;93(3):556-63.
Geraghty SR. Photo Album of Pumped Breastmilk. Breastfeed Med. 2010 Dec 6.
Vaughn LM, Ireton C, Geraghty SR, Diers T, Niño V, Falciglia GA, Valenzuela J, Mosbaugh C. Sociocultural influences on the determinants of breast-feeding by Latina mothers in the Cincinnati area. Fam Community Health. 2010 Oct-Dec;33(4):318-28.
Geraghty SR, List BA, Morrow GB. Guidelines for establishing a donor human milk depot. J Hum Lact. 2010 Feb;26(1):49-52.
Sarah W. Riddle, MD, IBCLC, FAAP Attending Physician, Hospital Medicine
Attending Physician, Hospital Medicine
Assistant Professor, UC Department of Pediatrics
Hospitalist medicine; breastfeeding medicine
Sarah Riddle, MD, IBCLC sees mothers and infants in the Breastfeeding Medicine Clinic and is an attending hospitalist on the inpatient units at Cincinnati Children’s Hospital Medical Center. She has a specialized interest in effects of acute hospitalization on the breastfeeding dyad.
MD: Johns Hopkins University School of Medicine, Baltimore, MD, 2001.IBCLC: International Board Certified Lactation Consultant, 2008.
Residency: Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2001-2004.
Chief Residency: Pediatrics, Cincinnati Children's Hospital Medical Center 2004-2005.
Certification: Pediatrics, 2004.
Geraghty SR, Riddle SW, Shaikh U. The breastfeeding mother and the pediatrician. J Hum Lactat. 2008;24(3):335-9.
List BA, Ballard JL, Langworthy KS, Vincent AM, Riddle SW, Tamayo OW, Geraghty SR. Electronic health records in an outpatient breastfeeding medicine clinic. J Hum Lactat. 2008 Feb;4(1):58-68.
Ellen S. Springer, MD, IBCLC Staff Physician
Ellen S. Springer, MD, works with the Center for Breast Feeding Medicine in an outpatient setting at Cincinnati Children’s Hospital Medical Center. She assists mothers and infants with breast feeding related issues.
MD: The Ohio State University College, Columbus, OH, 1995.
Residency: Cincinnati Children's Hospital Medical Center, 1998.
Certification: Board Certified, Pediatrics.
Jason S. Frischer, MD Director, Extracorporeal Membrane Oxygenation Program, Division of Pediatric General and Thoracic Surgery
Director, Extracorporeal Membrane Oxygenation Program, Division of Pediatric General and Thoracic Surgery
Assistant Professor, UC Department of Surgery
Chernoguz A, Crawford, K, Vandersall A, Willson T, Denson LA, Frischer JS. Pre-treatment with Anti-VEGF therapy may exacerbate inflammation in experimental acute colitis. J Pediatr Surg. 2012 Feb;47(2):347-54.
Le LD, Keswani SG, Biesiada J, Lim FY, Kingma PS, Haberman BE, Frischer J, Habli M, Crombleholme TM. The congenital diaphragmatic hernia composite prognostic index correlates with survival in left-sided congenital diaphragmatic hernia. J Pediatr Surg. 2012 Jan;47(1):57-62.
Lawal TA, Falcone RA, von Allmen D, Denson LA, Levitt MA, Warner BW, Frischer JS. The utility of routine pouchogram before ileostomy reversal in children and adolescents following ileal pouch anal anastomosis. J Pediatr Surg. 2011 Jun;46(6):1222-5.
Chernoguz A, Crawford KM, Donovan EC, Vandersall AE, Berglund C, Cripe TP, Frischer JS. EGFR Inhibition Fails to Suppress Vascular Proliferation and Tumor Growth in a Ewing’s Sarcoma Model. J Surg Res. 2012 Mar;173(1):1-9.
Lawal TA, Frischer JS, Falcone RA, Chatoorgoon K, Denson LA, Levitt MA. The transanal approach with laparoscopy or laparotomy for the treatment of rectal strictures in Crohn’s disease. J Laparoendosc Adv Surg Tech A. 2010 Nov;20(9):791-5.
Bischoff A, Gupta A, D’Mello S, Mezoff A, Podberesky D, Barnett S, Keswani S, Frischer JS. Crohn’s disease limited to the appendix: a case report in a pediatric patient. Pediatr Surg Int. 2010 Nov;26(11):1125-8.
Vuletin JF, Lim FY, Cnota J, Kline-Fath B, Salisbury S, Haberman B, Kingma P, Frischer JS, Crombleholme T. Prenatal pulmonary hypertension index: novel prenatal predictor of severe postnatal pulmonary artery hypertension in antenatally diagnosed congenital diaphragmatic hernia. J Pediatr Surg. 2010 Apr;45(4):703-8.
Frischer JS, Lee A, Serur A, Huang J, Bae JO, Kornfield ZN, Eljuga L, Shawber CJ, Feirt N, Mansukhani M, Stempak D, Baruchel S, Bender JG, Kandel JJ, Yamashiro DJ. Inhibition of cyclooxygenase-2 disrupts tumor vascular mural cell recruitment and survival signaling. Cancer Res. 2006 Apr;66(8):4378-84.
Frischer JS, Huang J, Serur A, Kadenhe-Chiweshe A, McCrudden KW, O’Toole K, Holash J, Yancopoulos GD, Yamashiro DJ, Kandel JJ. Effects of potent VEGF blockade on experimental Wilms tumor and its persisting vasculature. Int J Onc. 2004 Sep;25(3):549-53.
Huang J, Frischer JS, Serur A, Kadenhe A, Yokoi A, McCrudden KW, New T, O’Toole K, Zabski S, Rudge JS, Holash J, Yancopoulos GD, Yamashiro DJ, Kandel JJ. Regression of established tumors and metastases by potent vascular endothelial growth factor blockade. Proc Natl Acad Sci USA. 2003 June 24;100(13):7785-90.
Beth E. Haberman, MD Senior Medical Director, Neonatal Services
Senior Medical Director, Neonatal Services
Medical Director, Newborn Intensive Care Unit (NICU)
Medical Director, Neonatal Transport Program
Associate Director, High-Risk Infant Follow-Up Program
CDH and infant follow-up; care of infants with congenital diaphragmatic hernia; follow-up care of premature and term infants with complex medical needs
Vuletin JF, Lim FY, Cnota J, Kline-Fath B, Salisbury S, Haberman B, Kingma P, Frischer J, Crombleholme T. Prenatal pulmonary hypertension index: novel prenatal predictor of severe postnatal pulmonary artery hypertension in antenatally diagnosed congenital diaphragmatic hernia. J Pediatr Surg. 2010 Apr;45(4):703-8.Greenberg JM, Donovan EF, Warner BB, Haberman BE, Narendran V, Schibler KR. Neonatal Morbidities of Prenatal and Perinatal Origin. Creasy and Resnik”s Maternal-Fetal Medicine: Principles and Practice. 2008 6th ed. Chapter 58. Elsevier Ltd., Philadelphia, PA.Castro L, Yolton K, Haberman B, Roberto N, Hansen NI, Ambalavanan N, Vohr BR, Donovan EF. Bias in reported neurodevelopmental outcomes among extremely low birth weight survivors. Pediatrics. 2004 Aug;114(2):404-10.
Sundeep G. Keswani, MD Pediatric Surgeon, Division of General, Thoracic and Fetal Surgery
Pediatric Surgeon, Division of General, Thoracic and Fetal Surgery
Fetal Surgeon, Fetal Care Center of Cincinnati
Director, Pediatric Advanced Wound Care and Skin Services
Gene therapy applications; bone marrow contribution to tissue repair; fetal diagnosis and treatment
Dr. Sundeep G. Keswani is a pediatric and fetal surgeon. He is also the director of the Pediatric Advanced Wound Care and Skin Service (PAWS), which is a state-of-the-art wound care center devoted to the care of children. Dr. Keswani is the lead principal investigator in the Cincinnati Children’s Wound Healing Research Group, which is an NIH-funded laboratory that focuses on understanding the molecular mechanisms which underlie the fetus’ ability to regeneratively heal wounds with the goal of developing novel therapeutics to achieve regenerative wound healing in postnatal tissue.
Alice King MD, Swathi Balaji PhD, Louis D. Le MD, Emily Marsh, Timothy M. Crombleholme MD, Sundeep G. Keswani MD. Interleukin-10 Regulates Fetal Extracellular Matrix Hyaluronan Production. Journal of Pediatric Surgery. (In press).
Visscher M, King A, Nie AM, Schaffer P, Taylor T, Pruitt D, Giaccone MJ, Ashby M, Keswani S. A Quality-Improvement Collaborative Project to Reduce Pressure Ulcers in PICUs. Pediatrics. 2013 Jun;131(6):e1950-60.
Keswani SG, Balaji S, Le LD, Leung A, Parvadia JK, Frischer J, Yamano S, Taichman N, Crombleholme TM. Role of salivary vascular endothelial growth factor (VEGF) in palatal mucosal wound healing. Wound Repair Regen. 2013 Jun 11.
King A, Balaji S, Marsh E, Le LD, Shaaban AF, Crombleholme TM, Keswani SG. Interleukin-10 regulates the fetal hyaluronan-rich extracellular matrix via a STAT3-dependent mechanism. J Surg Res. 2013 Apr 24.
Balaji S, King A, Dhamija Y, Le LD, Shaaban AF, Crombleholme TM, Keswani SG. Pseudotyped adeno-associated viral vectors for gene transfer in dermal fibroblasts: implications for wound-healing applications. J Surg Res. 2013 Apr 3.
Keswani SG, Balaji S, Le L, Leung A, Katz AB, Lim FY, Habli M, Jones HN, Wilson JM, Crombleholme TM. Pseudotyped AAV vector-mediated gene transfer in a human fetal trachea xenograft model: implications for in utero gene therapy for cystic fibrosis. PLoS One. 2012;7(8):e43633.
Keswani SG, Balaji S, Le L, Leung A, Lim FY, Habli M, Jones HN, Wilson JM, Crombleholme TM. Pseudotyped adeno-associated viral vector tropism and transduction efficiencies in murine wound healing. Wound Repair Regen. 2012 Jul-Aug;20(4):592-600.
Gordon A, Kozin ED, Keswani SG, Vaikunth SS, Katz AB, Zoltick PW, Favata M, Radu AP, Soslowsky LJ, Herlyn M, Crombleholme TM. Permissive environment in postnatal wounds induced by adenoviral-mediated overexpression of the anti-inflammatory cytokine interleukin-10 prevents scar formation. Wound Repair Regen. 2008 Jan-Feb;16(1):70-9.
Javazon EH, Keswani SG, Badillo AT, Crombleholme TM, Zoltick PW, Radu AP, Kozin ED, Beggs K, Malik AA, Flake AW. Enhanced epithelial gap closure and increased angiogenesis in wounds of diabetic mice treated with adult murine bone marrow stromal progenitor cells. Wound Repair Regen. 2007 May-Jun;15(3):350-9.
Keswani SG, Katz AB, Lim FY, Zoltick P, Radu A, Alaee D, Herlyn M, Crombleholme TM. Adenoviral mediated gene transfer of PDGF-B enhances wound healing in type I and type II diabetic wounds. Wound Repair Regen. 2004 Sep-Oct;12(5):497-504.
Paul S. Kingma, MD, PhD Neonatal Director, Fetal Care Center of Cincinnati
Neonatal Director, Fetal Care Center of Cincinnati
Neonatology; congenital diaphragmatic hernia; neonatal infection
Innate immune systems; surfactant protein D; neutrophil function in Cystic Fibrosis
King BA, Boyd JT, Kingma PS. Pulmonary maturational arrest and death in a patient with pulmonary interstitial glycogenosis. Pediatr Pulmonol. 2011 May 26.
Lee TC, Lim FY, Keswani SG, Frischer JS, Haberman B, Kingma PS, Habli M, Jaekle RK, Sharp G, Kline-Fath B, Rubio EI, Calvo M, Guimaraes C, Crombleholme TM. Late gestation fetal magnetic resonance imaging-derived total lung volume predicts postnatal survival and need for extracorporeal membrane oxygenation support in isolated congenital diaphragmatic hernia. J Pediatr Surg. 2011 Jun;46(6):1165-71.
King BA, Kingma PS. Surfactant Protein D Deficiency Increases Lung Injury during Endotoxemia. Am J Respir Cell Mol Biol. 2011 May;44(5):709-15.
Vuletin JF, Lim FY, Cnota J, Kline-Fath B, Salisbury S, Haberman B, Kingma P, Frischer J, Crombleholme T. Prenatal pulmonary hypertension index: novel prenatal predictor of severe postnatal pulmonary artery hypertension in antenatally diagnosed congenital diaphragmatic hernia. J Pediatr Surg. 2010 Apr;45(4):703-8. White M, Kingma PS, Tecle T, Kacak N, Linders B, Heuser J, Crouch E, Hartshorn K. Multimerization of surfactant protein D, but not its collagen domain, is required for antiviral or opsonic activities related to influenza A virus. J Immunol. 2008 Dec 1;181(11):7936-43.
Kingma PS, Zhang L, Ikegami M, Hartshorn K, McCormack FX, Whitsett JA. Correction of pulmonary abnormalities in Sftpd-/- mice requires the collagenous domain of surfactant protein D. J Biol Chem. 2006 Aug 25;281(34):24496-505.
Kingma PS, Whitsett JA. In defense of the lung: surfactant protein A and surfactant protein D. Curr Opin Pharmacol. 2006 Jun;6(3):277-83.
Foong-Yen Lim, MD Surgical Director, Fetal Care Center of Cincinnati
Surgical Director, Fetal Care Center of Cincinnati
Associate Professor, UC Department of Surgery
William J. Polzin, MD MFM Co-Director, Fetal Care Center of Cincinnati
MFM Co-Director, Fetal Care Center of Cincinnati
BA: University of Wisconsin-Milwaukee; University of Wisconsin-Madison.
MD: Medical College of Wisconsin, Milwaukee, Wisconsin, 1983.Internship: Obstetrics and Gynecology, Madigan Army Medical Center, Tacoma, Washington, 1983-1984.Residency: Obstetrics and Gynecology, Madigan Army Medical Center, Tacoma, Washington, 1984-1987.Fellowship: Maternal-Fetal Medicine, Madigan Army Medical Center, Tacoma, Washington, 1989-1991.
Crombleholme TM, Lim FY, Habli M, Polzin W, Jaekle R, Michelfelder E, Cnota J, Liu C, Kim MO. Improved recipient survival with maternal nifedipine in twin-twin transfusion syndrome complicated by TTTS cardiomyopathy undergoing selective fetoscopic laser photocoagulation. Am J Obstet Gynecol. 2010 Oct;203(4):397.e1-9.
Habli M, Cnota J, Michelfelder E, Salisbury S, Schnell B, Polzin W, Lim FY, Crombleholme TM. The relationship between amniotic fluid levels of brain-type natriuretic peptide and recipient cardiomyopathy in twin-twin transfusion syndrome. Am J Obstet Gynecol. 2010 Oct;203(4):404.e1-7
Morris LM, Lim FY, Livingston JC, Polzin WJ, Crombleholme TM. High-risk fetal congenital pulmonary airway malformations have a variable response to steroids. J Pediatr Surg. 2009 Jan;44(1):60-5.
Michelfelder E, Polzin W, Hirsch R. Hypoplastic left heart syndrome with intact atrial septum: Utilization of a hybrid catheterization facility for cesarean section delivery and prompt neonatal intervention. Catheter Cardiovasc Interv. 2008 Dec 1;72(7):983-7.
Habli M, Michelfelder E, Livingston J, Harmon J, Lim FY, Polzin W, Crombleholme T. Acute effects of selective fetoscopic laser photocoagulation on recipient cardiac function in twin-twin transfusion syndrome. Am J Obstet Gynecol. 2008 Oct;199(4):412.e1-6.
Michelfelder E, Gottliebson W, Border W, Kinsel M, Polzin W, Livingston J, Khoury P, Crombleholme T. Early manifestations and spectrum of recipient twin cardiomyopathy in twin-twin transfusion syndrome: relation to Quintero stage. Ultrasound Obstet Gynecol. 2007 Dec;30(7):965-71. Livingston JC, Lim FY, Polzin W, Mason J, Crombleholme TM. Intrafetal radiofrequency ablation for twin reversed arterial perfusion (TRAP): a single-center experience. Am J Obstet Gynecol. 2007 Oct;197(4):399.e1-3. Crombleholme TM, Shera D, Lee H, Johnson M, D'Alton M, Porter F, Chyu J, Silver R, Abuhamad A, Saade G, Shields L, Kauffman D, Stone J, Albanese CT, Bahado-Singh R, Ball RH, Bilaniuk L, Coleman B, Farmer D, Feldstein V, Harrison MR, Hedrick H, Livingston J, Lorenz RP, Miller DA, Norton ME, Polzin WJ, Robinson JN, Rychik J, Sandberg PL, Seri I, Simon E, Simpson LL, Yedigarova L, Wilson RD, Young B. A prospective, randomized, multicenter trial of amnioreduction vs selective fetoscopic laser photocoagulation for the treatment of severe twin-twin transfusion syndrome. Am J Obstet Gynecol. 2007 Oct;197(4):396.e1-9.
Coppage KH, Polzin WJ. Severe Preeclampsia and Delivery Outcomes: Is Immediate Cesarean Delivery Beneficial? Am J Obstet Gynecol. 2002;186:921-3.
James W. Van Hook, MD MFM Co-Director, Fetal Care Center of Cincinnati
Director, Maternal Fetal Medicine, University Hospital
Mulla ZD, Nuwayhid BS, Garcia KM, Flood-Shaffer K, Van Hook JW, Hampton RM. Risk factors for a prolonged length of stay in women hospitalized for preeclampsia in Texas. Hypertens Pregnancy. 2010 Jan;29(1):54-68. Vrabec JT, Isaacson B, Van Hook JW. Bell's palsy and pregnancy. Otolaryngol Head Neck Surg. 2007 Dec;137(6):858-61. Kauffman RP, Castracane VD, Peghee D, Baker TE, Van Hook JW. Detection of gestational diabetes mellitus by homeostatic indices of insulin sensitivity: a preliminary study. Am J Obstet Gynecol. 2006 Jun;194(6):1576-82 Tiwari R, Hicks K, Naqvi M, Biskinis E, Nirgiotis J, Van Hook J, Suffield R. Prenatal diagnosis of a neonate with fetus in fetu. J Perinatol. 2006;26:366-367.
Van Hook JW. Substance Abuse and Addiction. In Evans A (ed) Manual of Obstetrics. 7th ed. Lippincott, Williams and Wilkins, 2007. Van Hook JW. Trauma in Pregnancy for Critical Care Obstetrics. In Belfort M, Saade G, Foley M, Phelan J, Dildy G (eds) Critical Care Obstetrics. 5th ed. Malden, Massachusetts: Blackwell Science, 2008.
Tanya E. Cahill, MD Director, High-Risk Clinic
Director, High-Risk Clinic
High risk infant follow up; neonatal abstinence syndrome
Thomas R. Korfhagen, MD, PhD Attending Neonatologist
Care of High Risk infants; pediatric patients with complex, long term medical problems
Roles and mechanisms whereby surfactant proteins A, B, D, Relm peptides and EGF-R signaling control lung infections, inflammation and responses to lung injury. Translational studies assessing processes to reduce the extent of lung injury and remodeling in neonates and adults.
Hassett DJ, Korfhagen TR, Irvin RT, Schurr MJ, Sauer K, Lau GW, Sutton MD, Yu H, Hoiby N. Pseudomonas aeruginosa biofilm infections in cystic fibrosis: insights into pathogenic processes and treatment strategies. Expert Opin Ther Targets. 2010 Feb;14(2):117-30. Review.
Le Cras TD, Korfhagen TR, Davidson C, Schmidt S, Fenchel M, Ikegami M, Whitsett JA, Hardie WD. Inhibition of PI3K by PX-866 prevents transforming growth factor-alpha-induced pulmonary fibrosis. Am J Pathol. 2010 Feb;176(2):679-86.
Chen G, Korfhagen TR, Xu Y, Kitzmiller J, Wert SE, Maeda Y, Gregorieff A, Clevers H, Whitsett JA. SPDEF is required for mouse pulmonary goblet cell differentiation and regulates a network of genes associated with mucus production. J Clin Invest. 2009 Oct;119(10):2914-24.
Deshmukh HS, McLachlan A, Atkinson JJ, Hardie WD, Korfhagen TR, Dietsch M, Liu Y, Di PY, Wesselkamper SC, Borchers MT, Leikauf GD. Matrix metalloproteinase-14 mediates a phenotypic shift in the airways to increase mucin production. Am J Respir Crit Care Med. 2009 Nov 1;180(9):834-45.
Glasser SW, Witt TL, Senft AP, Baatz JE, Folger D, Maxfield MD, Akinbi HT, Newton DA, Prows DR, Korfhagen TR. Surfactant protein C-deficient mice are susceptible to respiratory syncytial virus infection. Am J Physiol Lung Cell Mol Physiol. 2009 Jul;297(1):L64-72.
Korfhagen TR, Le Cras TD, Davidson CR, Schmidt SM, Ikegami M, Whitsett JA, Hardie WD. Rapamycin prevents transforming growth factor-alpha-induced pulmonary fibrosis. Am J Respir Cell Mol Biol. 2009 Nov;41(5):562-72.
Kramer EL, Mushaben EM, Pastura PA, Acciani TH, Deutsch GH, Khurana Hershey GK, Korfhagen TR, Hardie WD, Whitsett JA, Le Cras TD. Early growth response-1 suppresses epidermal growth factor receptor-mediated airway hyperresponsiveness and lung remodeling in mice. Am J Respir Cell Mol Biol. 2009 Oct;41(4):415-25.
Glasser SW, Senft AP, Whitsett JA, Maxfield MD, Ross GF, Richardson TR, Prows DR, Xu Y, Korfhagen TR. Macrophage dysfunction and susceptibility to pulmonary Pseudomonas aeruginosa infection in surfactant protein C-deficient mice. J Immunol. 2008 Jul 1;181(1):621-8.
Hardie WD, Davidson C, Ikegami M, Leikauf GD, Le Cras TD, Prestridge A, Whitsett JA, Korfhagen TR. EGF receptor tyrosine kinase inhibitors diminish transforming growth factor-alpha-induced pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol. 2008 Jun;294(6):L1217-25.
Deshmukh HS, Shaver C, Case LM, Dietsch M, Wesselkamper SC, Hardie WD, Korfhagen TR, Corradi M, Nadel JA, Borchers MT, Leikauf GD. Acrolein-activated matrix metalloproteinase 9 contributes to persistent mucin production. Am J Respir Cell Mol Biol. 2008 Apr;38(4):446-54.
Stephanie L. Merhar, MD, MS Attending Neonatologist
Merhar S. Biomarkers in neonatal posthemorrhagic hydrocephalus. Neonatology. 2011 Jul;101(1):1-7.
Merhar SL, Schibler KR, Sherwin CM, Meinzen-Derr J, Shi J, Balmakund T, Vinks AA. Pharmacokinetics of levetiracetam in neonates with seizures. J Pediatrics. 2011 Jul;159(1):152-154. Merhar SL, Manning-Courtney P. Two boys with 47 XXY and autism. J Autism Devl Disord. 2007 May;37(5):840-6. Merhar SL, Gilbert DL. Clinical (video) findings and cerebrospinal fluid neurotransmitters in 2 children with severe chronic bilirubin encephalopathy, including a former preterm infant without marked hyperbilirubinemia. Pediatrics. 2005 Nov;116(5):1226-30. Levy SE, Mandell DS, Merhar SL, Ittenbach RF, Pinto-Martin JA. Use of complementary and alternative medicine among children recently diagnosed with autistic spectrum disorder. J Dev Behav Ped. 2003 Dec;24(6):418-423.
Ajay B. Ponkshe, MD Staff Physician, Neonatology
Staff Physician, Neonatology
Henry T. Akinbi, MD Attending Neonatologist
Neonatal infections; blood transfusions; role of Lysozyme in airway host defense
McDowell SA, Ma Y, Kusano R, Akinbi HT. Simvastatin is Protective During Staphylococcus aureus Pneumonia. Curr Pharm Biotechnol. 2011 Mar 14.
Kuang Z, Hao Y, Hwang S, Zhang S, Kim E, Akinbi HT, Schurr MJ, Irvin RT, Hassett DJ, Lau GW. The Pseudomonas aeruginosa flagellum confers resistance to pulmonary surfactant protein-A by impacting the production of exoproteases through quorum-sensing. Mol Microbiol. 2011 Mar;79(5):1220-35.
Isemann B, Meinzen-Derr J, Akinbi H. Maternal and neonatal factors impacting response to methadone therapy in infants treated for neonatal abstinence syndrome. J Perinatol. 2011 Jan;31(1):25-9. Slaughter JL, Meinzen-Derr J, Rose SR, Leslie ND, Chandrasekar R, Linard SM, Akinbi HT. The effects of gestational age and birth weight on false-positive newborn-screening rates. Pediatrics. 2010 Nov;126(5):910-6.
Akinbi H, Meinzen-Derr J, Auer C, Ma Y, Pullum D, Kusano R, Reszka KJ, Zimmerly K. Alterations in the host defense properties of human milk following prolonged storage or pasteurization. J Pediatr Gastroenterol Nutr. 2010 Sep;51(3):347-52. Yang L, Johansson J, Ridsdale R, Willander H, Fitzen M, Akinbi HT, Weaver TE. Surfactant protein B propeptide contains a saposin-like protein domain with antimicrobial activity at low pH. J Immunol. 2010 Jan 15;184(2):975-83. Glasser SW, Witt TL, Senft AP, Baatz JE, Folger D, Maxfield MD, Akinbi HT, Newton DA, Prows DR, Korfhagen TR. Surfactant protein C-deficient mice are susceptible to respiratory syncytial virus infection. Am J Physiol Lung Cell Mol Physiol. 2009 Jul;297(1):L64-72. Walker VP, Akinbi HT, Meinzen-Derr J, Narendran V, Visscher M, Hoath SB. Host defense proteins on the surface of neonatal skin: implications for innate immunity. J Pediatr. 2008 Jun;152(6):777-81.
Nash JA, Ballard TN, Weaver TE, Akinbi HT. The peptidoglycan-degrading property of lysozyme is not required for bactericidal activity in vivo. J Immunol. 2006 Jul 1;177(1):519-26 Ryan MA, Akinbi HT, Serrano AG, Perez-Gil J, Wu H, McCormack FX, Weaver TE. Antimicrobial activity of native and synthetic surfactant protein B peptides. J Immunol. 2006 Jan 1;176(1):416-25.
Laurel B. Bookman, MD Medical Director, TriHealth Nurseries
Medical Director, TriHealth Nurseries
Chair, Neonatal Pediatrics
Quality improvement; global health
Mary C. Burwinkel, MD Staff Physician, Neonatology, Pulmonary Biology
Staff Physician, Neonatology, Pulmonary Biology
Michael W. Crossman, MD, PhD Attending Neonatologist
PhD: Biochemistry, St. Louis University, St. Louis Mo., 1985.
MD: St. Louis University, St. Louis, Mo., 1986.
Residency: Pediatrics, Children's Hospital Medical Center, Cincinnati, Ohio, 1986-1989; Chief resident, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, 1989-1990.
Fellowship: Neonatal- Perinatal Medical Fellowship, Washington University School of Medicine, 1990-1993.Certification: Neonatal - Perinatal Medicine, 1995, 2003.
Crossman MW. For Whom the Bells Toll… J Pediatrics. 2007;151(1):4-5.
Mishra A, Hogan SP, Brandt EB, Wagner N, Crossman MW, Foster PS, Rothenberg ME. Enterocyte expression of the eotaxin and interleukin-5 transgenes induces compartmentalized dysregulation of eosinophil trafficking. J Biol Chem. 2002 Feb 8;277(6):4406-12. Arrese M, Trauner M, Sacchiero RJ, Crossman MW, Scheider BL. Neither Intestinal Sequestration of Bile Acids nor Common Bile Duct Ligation Modulate the Expression and Function of the Rat Ileal Bile Acid Transporter. Hepatology. 1998;28:1081-1087.
Shneider BL, Setchell KDR, Crossman MW. Fetal and Neonatal Expression of the Apical Sodium-Dependent Bile Acid Transporter in the Rat Ileum and Kidney. Pediatric Research. 1997;42:189-194.
Diane K. Donley, MD Staff Physician, Neonatology
Teen pregnancy; parent education
Jay H. Dritz, MD Attending Neonatologist
MD: Washington University School of Medicine, St. Louis, MO, 2001.
Residency: Pediatrics, St. Louis Children’s Hospital, St. Louis, MO, 2001-2004.
Fellowship: Neonatal-Perinatal Medicine, St. Louis Children’s Hospital, St. Louis, MO, 2004-2007.
Certification: Pediatrics, 2004; Neonatology, 2008.
Joshua C. Euteneuer, MD Clinical Fellow, Division of Neonatology
Clinical Fellow, Division of Neonatology
MD: University of Nebraska Medical Center, Omaha, NE, 2010.
Residency: Pediatrics, Washington University in St. Louis/St. Louis Children's Hospital, St. Louis, MO, 2013.
Horacio S. Falciglia, MD Professor Emeritus, Neonatology and Perinatal Biology
Professor Emeritus, Neonatology and Perinatal Biology
Board Certified General Pediatrics
Meconium Aspiration Syndrome; pathophysiology
Relationship of Selenium Status to Sepsis in extremely premature infants
Horacio Falciglia, MD, serves as the Director of the Vermont Oxford Database, where he finds his work both challenging and interesting. This work allows the division to compare local (Cincinnati) neonatal outcomes, morbidities, and mortality in premature infants under 1500 grams with 600 other NICUs in the US and abroad. Dr. Falciglia also enjoys sharing years of clinical experience with new graduates and students as he teaches medical students and residents at the bedside. Dr. Falciglia's past research on Meconium Aspiration has been exciting and rewarding, and his research is leading to the understanding of the pathophysiology of this complex disease. The incidence of this disease has been drastically reduced through research and improved perinatal care.
Michelle L. French, MD Staff Physician, Neonatology
Neera K. Goyal, MD, MSHP Attending Physician, Hospital Medicine
Quality of care during birth hospitalization for late preterm and other high risk newborns; neonatal readmission; prevention of preterm birth
Neera Goyal, MD MSHP, is a general pediatrician and a child health researcher. Her research interests are in perinatal care – in particular, how Level 1 and Level 2 birth hospitals manage higher risk term and late preterm newborns. She has studied the impact of delivery volume, teaching affiliation, and patient insurance on adherence to guidelines for postpartum length of stay, and she is currently researching the impact of discharge timing on risk of readmission for late preterm newborns. She has also conducted research on the impact of late preterm birth on early childhood respiratory morbidity and physical development. Dr. Goyal’s work has been published in peer-reviewed literature, and in 2011 she received the Pediatric Academic Societies Travel Award for Young Investigators.
Originally from Dallas, TX, Dr. Goyal received her bachelor’s degree in Atlanta, Georgia at Emory University, majoring in Philosophy. She earned her M.D. from University of Texas Southwestern Medical Center in Dallas. She completed a pediatrics residency at Children’s Hospital of Philadelphia in 2008 and worked as a neonatology hospitalist from 2008-2009. She then pursued further training in health services research as a Robert Wood Johnson Foundation Clinical Scholar at University of Pennsylvania in Philadelphia. She joined Cincinnati Children’s Hospital Medical Center in 2011 as a faculty member with a joint appointment in the Division of Neonatology and the Division of General and Community Pediatrics, Section of Hospital Medicine.
MD: Univ. of Texas Southwestern Medical Center at Dallas, 2005.
Residency: Pediatrics, Children’s Hospital of Philadelphia, 2008.
Fellowship: The Robert Wood Johnson Foundation Clinical Scholars, University of Pennsylvania, 2011
Certification: Pediatrics, 2008.
Goyal N, Fiks A, Lorch SA. The association of late preterm birth with asthma in young children: A practice-based study. Pediatrics. 2011.
Goyal N, Fager C, Lorch SA. Adherence to discharge guidelines for late preterm newborns. Pediatrics. 2011 Jul;128(1):62-71.
Preciado DA, Rutter MJ, Greenberg JM, Bahado