Clinical Interests

Pulmonary alveolar proteinosis; cystic fibrosis; alpha-1 antitrypsin deficiency; other rare lung disorders

Research Interests

Alveolar macrophage function; molecular techniques using gene knockout, transgenic and conditional gene expression mouse models and non-human primates, in vitro and in vivo viral gene transfer, and bone marrow transplantation
 

MS: Genetics, The George Washington University, Washington, DC, 1981.

MD: University of Maryland School of Medicine, Baltimore, MD, 1984.

Residency: Internal Medicine, The Ohio State University Hospitals, Columbus, OH, 1987.

Fellowship: Pulmonary Medicine, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, MD, 1989.

Certification: Diplomate in Internal Medicine, American Board of Internal Medicine, 1987; Diplomate, National Board of Medical Examiners, 1987; Diplomate in Pulmonary Medicine, American Board of Internal Medicine, 2000 .

Wu H, Suzuki T, Carey B, Trapnell BC, McCormack FX. Keratinocyte growth factor (KGF) augments pulmonary innate immunity through epithelium-driven, GM-CSF dependent paracrine activation of alveolar macrophages. J Biol Chem. 2011 Feb 22.

D'Mello S, Trauernicht A, Ryan A, Bonkowski E, Willson T, Trapnell BC, Frank SJ, Kugasathan S, Denson LA. Innate dysfunction promotes linear growth failure in pediatric Crohn's disease and growth hormone resistance in murine ileitis. Inflamm Bowel Dis. 2011 Feb 18.

Suzuki T, Sakagami T, Young LR, Carey BC, Wood RE, Luisetti M, Wert SE, Rubin BK, Kevill K, Chalk C, Whitsett JA, Stevens C, Nogee LM, Campo I, Trapnell BC. Hereditary pulmonary alveolar proteinosis: pathogenesis, presentation, diagnosis, and therapy. Am J Respir Crit Care Med. 2010 Nov 15;182(10):1292-304. 

Young LR, Vandyke R, Gulleman PM, Inoue Y, Brown KK, Schmidt LS, Linehan WM, Hajjar F, Kinder BW, Trapnell BC, Bissler JJ, Franz DN, McCormack FX. Serum vascular endothelial growth factor-D prospectively distinguishes lymphangioleiomyomatosis from other diseases. Chest. 2010 Sep;138(3):674-81.

Han X, Gilbert S, Groschwitz K, Hogan S, Jurickova I, Trapnell B, Samson C, Gully J. Loss of GM-CSF signalling in non-haematopoietic cells increases NSAID ileal injury. Gut. 2010 Aug;59(8):1066-78. 

Sakagami T, Beck D, Uchida K, Suzuki T, Carey BC, Nakata K, Keller G, Wood RE, Wert SE, Ikegami M, Whitsett JA, Luisetti M, Davies S, Krischer JP, Brody A, Ryckman F, Trapnell BC. Patient-derived granulocyte/macrophage colony-stimulating factor autoantibodies reproduce pulmonary alveolar proteinosis in nonhuman primates. Am J Respir Crit Care Med. 2010 Jul 1;182(1):49-61.

Carey B, Trapnell BC. The molecular basis of pulmonary alveolar proteinosis. Clin Immunol. 2010 May;135(2):223-35. 

Trapnell BC, Maguiness K, Graff GR, Boyd D, Beckmann K, Caras S. Efficacy and safety of Creon 24,000 in subjects with exocrine pancreatic insufficiency due to cystic fibrosis. J Cyst Fibros. 2009 Dec;8(6):370-7 

Trapnell BC, Carey BC, Uchida K, Suzuki T. Pulmonary alveolar proteinosis, a primary immunodeficiency of impaired GM-CSF stimulation of macrophages. Curr Opin Immunol. 2009 Oct;21(5):514-21.

Uchida K, Nakata K, Suzuki T, Luisetti M, Watanabe M, Koch DE, Stevens CA, Beck DC, Denson LA, Carey BC, Keicho N, Krischer JP, Yamada Y, Trapnell BC. Granulocyte/macrophage-colony-stimulating factor autoantibodies and myeloid cell immune functions in healthy subjects. Blood. 2009 Mar 12;113(11):2547-56. 

DO: Philadelphia College of Osteopathic Medicine, 1983

Residency: Pediatrics, Children's Medical Center, Dallas, TX

Fellowship: Pediatric Pulmonary Medicine, Tulane University Medical School, New Orleans, LA

Certification: Pediatrics, 1989; Pediatric Pulmonology, 1994.

Burrow TA, Cohen MB, Bokulic R, Deutsch G, Choudhary A, Falcone RA Jr, Grabowski GA. Gaucher disease: progressive mesenteric and mediastinal lymphadenopathy despite enzyme therapy. J Pediatr. 2007 Feb;150(2):202-6. 

Amin RS, Carroll JL, Jeffries JL, Grone C, Bean JA, Chini B, Bokulic R, Daniels SR. Twenty-four-hour ambulatory blood pressure in children with sleep-disordered breathing. Am J Respir Crit Care Med. 2004 Apr 15;169(8):950-6. 

Evans DA, Bokulic RE. Radiological case of the month. Posttraumatic pseudocysts. Arch Pediatr Adolesc Med. 1997 Aug;151(8):47-9. 

Hardie W, Bokulic R, Garcia VF, Reising SF, Christie CD. Pneumococcal pleural empyemas in children. Clin Infect Dis. 1996 Jun;22(6):1057-63. 

Bokulic RE, Hilman BC. Interstitial lung disease in children. Pediatr Clin North Am. 1994 Jun;41(3):543-67. 

Kercsmar C. Exhaled nitric oxide in the diagnosis and management of childhood asthma. Ther Adv Respir Dis. 2010 Apr;4(2):71-82.

Kattan M, Kumar R, Bloomberg GR, Mitchell HE, Calatroni A, Gergen PJ, Kercsmar CM, Visness CM, Matsui EJ, Steinbach SF, Szefler SJ, Sorkness CA, Morgan WJ, Teach SJ, Gan VJ. Asthma control, adiposity, and adipokines among inner-city adolescents. J Allergy Clin Immunol. 2010 125:584-92.

Rohan J, Drotar D, McNally K, Schluchter M, Riekert K, Vavrek P, Schmidt A, Redline S, Kercsmar C. Adherence to pediatric asthma treatment in economically disadvantaged African-American children and adolescents: an application of growth curve analysis. J Pediatr Psychol. 2010 May;35(4):394-404.

Ross KR, Hart MA, Storfer-Isser A, Kibler AM, Johnson NL, Rosen CL, Kercsmar CM, Redline S. Obesity and obesity related co-morbidities in a referral population of children with asthma. Pediatr Pulmonol. 2009 Sep;44(9):877-84. 

McNally KA, Rohan J, Schluchter M, Riekert KA, Vavrek P, Schmidt A, Redline S, Kercsmar C, Drotar D. Adherence to combined montelukast and fluticasone treatment in economically disadvantaged African American youth with asthma. J Asthma. 2009 Nov;46(9):921-7.

Kercsmar CM, McDowell KM. Love it or Lev it: Levalbuterol for severe acute asthma; for now, leave it. J Pediatr. 2009 155:163-64.

Short EJ, Kirchner HL, Asaad GR, Fulton S, Lewis B, Eisengart S, Baley J, Kercsmar C, Min MO, Singer LT. Long-term Sequelae of Postnatal Surfactant and Corticosteroid Therapies. BPD J Perinatol. 2008 Jul; 28(7):498-504.

Szefler SL, Mirchell H, , Sorkness CA, Gergen PJ, O'Connor GT, Morgan WJ, Kattan M, Pongracic JA, Teach SJ, , Bloomberg GR, Eggleston PA, Gruchalla RS, Kercsmar CM, Liu, AH, Wildfire JJ, Busse WW. Management of asthma based on exhaled nitric oxide in addition to guideline-based treatment for inner-city adolescents and young adults: a randomised controlled trial. Lancet. 2008 372:1065-72.

Kercsmar CM. Meeting the challenges of asthma: conference summary. Respir Care. 2008 Jun;53(6):787-95.

Sobande PO, Kercsmar CM. Inhaled corticosteroids in asthma management. Respir Care. 2008 May;53(5):625-33; discussion 633-4. Review.

Clinical Interests

Medical Education; outcomes research; quality improvement; sleep medicine; thoracic insufficiency syndrome

Research Interests

Medical Education; Pulmonary Vascular Disease; Thoracic Insufficiency Syndrome

McPhail GL, Weiland J, Acton JD, Ednick M, Chima A, VanDyke R, Fenchel MC, Amin RS, Seid M. Improving evidence-based care in cystic fibrosis through quality improvement. Arch Pediatr Adolesc Med. 2010 Oct;164(10):957-60.

McPhail GL, Ednick MD, Fenchel MC, VanDyke R, Chima A, Amin RS, Seid M. Improving follow-up in hospitalised children. Qual Saf Health Care. 2010 Oct;19(5):e35

Ednick M, Cohen AP, McPhail GL, Beebe D, Simakajornboon N, Amin RS. A review of the effects of sleep during the first year of life on cognitive, psychomotor, and temperament development. Sleep. 2009 Nov 1;32(11):1449-58. Review.

McPhail GL, Acton JD, Fenchel MC, Amin RS, Seid M. Improvements in lung function outcomes in children with cystic fibrosis are associated with better nutrition, fewer chronic pseudomonas aeruginosa infections, and dornase alfa use. J Pediatr. 2008 Dec;153(6):752-7.

McPhail GL. Coagulation disorder as a presentation of cystic fibrosis. J Emerg Med. 2010 Apr;38(3):320-2.

Amin R, Somers VK, McConnell K, Willging P, Myer C, Sherman M, McPhail G, Morgenthal A, Fenchel M, Bean J, Kimball T, Daniels S. Activity-adjusted 24-hour ambulatory blood pressure and cardiac remodeling in children with sleep disordered breathing. Hypertension. 2008 Jan;51(1):84-91.

McPhail GL, Hardie WD. Cavitary lung lesions in a 2-year-old child. Respiration. 2008;76(1):117-8.

Suzuki T, Sakagami T, Young LR, Carey BC, Wood RE, Luisetti M, Wert SE, Rubin BK, Kevill K, Chalk C, Whitsett JA, Stevens C, Nogee LM, Campo I, Trapnell BC. Hereditary pulmonary alveolar proteinosis: pathogenesis, presentation, diagnosis, and therapy. Am J Respir Crit Care Med. 2010 Nov 15;182(10):1292-304.

Sakagami T, Beck D, Uchida K, Suzuki T, Carey BC, Nakata K, Keller G, Wood RE, Wert SE, Ikegami M, Whitsett JA, Luisetti M, Davies S, Krischer JP, Brody A, Ryckman F, Trapnell BC. Patient-derived granulocyte/macrophage colony-stimulating factor autoantibodies reproduce pulmonary alveolar proteinosis in nonhuman primates. Am J Respir Crit Care Med. 2010 Jul 1;182(1):49-61.

Abman S, Jobe A, Chernick V, Blaisdell C, Castro M, Ramirez MI, Gern JE, Cutting G, Redding G, Hagood JS, Whitsett J, Abman S, Raj JU, Barst R, Kato GJ, Gozal D, Haddad GG, Prabhakar NR, Gauda E, Martinez FD, Tepper R, Wood RE, Accurso F, Teague WG, Venegas J, Cole FS, Wright RJ, Gail D, Hamvas A, Kercsmar C, Kiley J, Weinmann G; NHLBI working group report. Strategic plan for pediatric respiratory diseases research: an NHLBI working group report. Pediatr Pulmonol. 2009 Jan;44(1):2-13.

Muenzer J, Beck M, Eng CM, Escolar ML, Giugliani R, Guffon NH, Harmatz P, Kamin W, Kampmann C, Kosepglu ST, Link B, Martin RA, Molter DW, MuAoz Rojas MV, Ogilvie JW, Parini R, Ramaswami U, Scarpa M, Schwartz IV, Wood RE, Wraith E. Multidisciplinary Management of Hunter Syndrome. Pediatrics. 2009; 124:e1228-39.

Suzuki T, Sakagami T, Rubin BK, Nogee LM, Wood RE, Zimmerman SL, Smolarek T, Dishop MK, Wert SE, Whitsett JA, Grabowski G, Carey BC, Stevens C, van der Loo JC, Trapnell BC. Familial pulmonary alveolar proteinosis caused by mutations in CSF2RA. J Exp Med. 2008 Nov 24;205(12):2703-10. 

Wood RE. Evaluation of the upper airway in children. Curr Opin Pediatr. 2008 Jun;20(3):266-71. Review.

Boesch RP, Daines C, Willging JP, Kaul A, Cohen AP, Wood RE, Amin RS. Advances in the diagnosis and management of chronic pulmonary aspiration in children. Eur Respir J. 2006 Oct;28(4):847-61. Review.

Zur KB, Wood RE, Elluru RG. Pediatric postcricoid vascular malformation: a diagnostic and treatment challenge. Int J Pediatr Otorhinolaryngol. 2005 Dec;69(12):1697-701.

Lim LH, Cotton RT, Azizkhan RG, Wood RE, Cohen AP, Rutter MJ. Complications of metallic stents in the pediatric airway. Otolaryngol Head Neck Surg. 2004 Oct;131(4):355-61. 

Wood RE. The emerging role of flexible bronchoscopy in pediatrics. Clin Chest Med. 2001 Jun;22(2):311-7, viii. Review.

Research Interests

Dr. Boyd's current research interest is the pathogenesis of interstitial lung disease and developmental lung disorders of infancy. He also has an interest in graduate medical education.

Clinical Interests

Dr. Boyd has worked as an academic pediatric pathologist at Cincinnati Children's since 2008. He functions as a surgical and autopsy pathologist.

Pediatric thoracic imaging; cystic fibrosis; diffuse lung disease

AB: Biology, Kenyon College, Gambier, OH, 1975.

MD: Albert Einstein College of Medicine, Bronx, NY, 1980.

Residency: Pediatrics, University of California San Francisco, San Francisco, CA, 1980-1983; Radiology, University of California San Francisco, San Francisco, CA, 1983-1986.

Fellowship: Pediatric Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 1986-1987.

Certification: Pediatrics, 1986; Radiology, 1986; Certificate of Additional Qualification in Pediatric Radiology, 1995.

McCormack FX, Inoue Y, Moss J, Singer LG, Strange C, Nakata K, Barker AF, Chapman JT, Brantly ML, Stocks JM, Brown KK, Lynch JP 3rd, Goldberg HJ, Young LR, Kinder BW, Downey GP, Sullivan EJ, Colby TV, McKay RT, Cohen MM, Korbee L, Taveira-DaSilva AM, Lee HS, Krischer JP, Trapnell BC; National Institutes of Health Rare Lung Diseases Consortium; MILES Trial Group. Efficacy and safety of sirolimus in lymphangioleiomyomatosis. N Engl J Med. 2011 Apr 28;364(17):1595-606.

Donnelly LF, Gessner KE, Dickerson JM, Koch BL, Towbin AJ, Lehkamp TW, Moskovitz J, Brody AS, Dumoulin CL, Jones BV. Quality initiatives: department scorecard: a tool to help drive imaging care delivery performance. Radiographics. 2010 Nov;30(7):2029-38.

Brody AS, Guillerman RP, Hay TC, Wagner BD, Young LR, Deutsch GH, Fan LL, Deterding RR. Neuroendocrine cell hyperplasia of infancy: diagnosis with high-resolution CT. AJR Am J Roentgenol. 2010 Jan;194(1):238-44.

Rattan AS, Laor T, Ryckman FC, Brody AS. Pectus excavatum imaging: enough but not too much. Pediatr Radiol. 2010 Feb;40(2):168-72.

Schmithorst VJ, Altes TA, Young LR, Franz DN, Bissler JJ, McCormack FX, Dardzinski BJ, Brody AS. Automated algorithm for quantifying the extent of cystic change on volumetric chest CT: initial results in Lymphangioleiomyomatosis. AJR Am J Roentgenol. 2009 Apr;192(4):1037-44.

Brody AS, Donnelly LF. Building a culture of research among clinical pediatric radiologists: a multifaceted, programmatic approach. Pediatr Radiol. 2009 Apr;39(4):367-70.

Brody AS. New perspectives in imaging interstitial lung disease in children. Pediatr Radiol. 2008 May;38 Suppl 2:S205-7. Review.

Bissler JJ, McCormack FX, Young LR, Elwing JM, Chuck G, Leonard JM, Schmithorst VJ, Laor T, Brody AS, Bean J, Salisbury S, Franz DN. Sirolimus for angiomyolipoma in tuberous sclerosis complex or lymphangioleiomyomatosis. N Engl J Med. 2008 Jan 10;358(2):140-51.

Deutsch GH, Young LR, Deterding RR, Fan LL, Dell SD, Bean JA, Brody AS, Nogee LM, Trapnell BC, Langston C; Pathology Cooperative Group, Albright EA, Askin FB, Baker P, Chou PM, Cool CM, Coventry SC, Cutz E, Davis MM, Dishop MK, Galambos C, Patterson K, Travis WD, Wert SE, White FV; ChILD Research Co-operative. Diffuse lung disease in young children: application of a novel classification scheme. Am J Respir Crit Care Med. 2007 Dec 1;176(11):1120-8. Epub 2007 Sep 20.

Brody AS. Computed tomography scanning in cystic fibrosis research trials: practical lessons from three clinical trials in the United States. Proc Am Thorac Soc. 2007 Aug 1;4(4):350-4.

MD: University College Cork, Ireland, 1990.

Residency: Radiology, Cork University Hospital, Ireland

Fellowship in Thoracic Imaging: Duke University Medical Center, Durham, NC, 1999-2000.

Fellowship in Pediatric Radiology: Cincinnati Children's, Cincinnati, OH, 2000-2001.

Certification: FFRRCSI, 1998; American Board of Radiology, 2005; American Board of Radiology-Pediatrics, 2006.

Kim HK, Crotty E. Bilateral testicular adrenal rests in a boy with congenital adrenal hyperplasia. Pediatr Radiol. 2010 Dec;40 Suppl 1:25.

Kim HK, Crotty E. Post-traumatic osteolysis of the distal clavicle. Pediatr Radiol. 2010 May;40(5):784.

Hirsch R, Gottliebson W, Crotty E, Fleck R, Strife J. Computed tomography angiography with three-dimensional reconstruction for pulmonary venous definition in high-risk infants with congenital heart disease. Congenit Heart Dis. 2006 May;1(3):104-10.

Brody AS, Crotty EJ. Neuroendocrine cell hyperplasia of infancy (NEHI). Pediatr Radiol. 2006 Dec;36(12):1328. 

Wansapura J, Fleck R, Crotty E et al. Frequency scouting for cardiac imaging with SSFP at 3 Tesla. Pediatr Radiol. 2006;36(10):1082-1085.

Wansapura J, Gottliebson W, Crotty E, et al. Cyclic variation of T1 in the myocardium at 3 T. Magn Reson Imaging. 2006. 24(7):889-893.

Obesity surgery and research; neonatal surgery; gastroesophageal reflux disease; minimally invasive surgery; thoracic surgery

BS: College of William and Mary, Williamsburg, VA, 1987.

MD: Medical College of Virginia, Virginia Commonwealth University, Richmond, VA, 1993.

PhD: Virginia Commonwealth University, Richmond, VA, 1993.

Residency: Stanford University Hospital, Stanford, CA, 1998.

Fellowship: Children's Hospital of Alabama, Birmingham, AL, 2000.

Board Certification: Diplomate of the American Board of Surgery, December 1999; Certification in Pediatric Surgery, American Board of Surgery, March 2002.

Zeller MH, Guilfoyle SM, Reiter-Purtill J, Ratcliff MB, Inge TH, Long JD. Adolescent bariatric surgery: caregiver and family functioning across the first postoperative year. Surg Obes Relat Dis. 2010 Jul 29.

Ratcliff MB, Reiter-Purtill J, Inge TH, Zeller MH. Changes in depressive symptoms among adolescent bariatric candidates from preoperative psychological evaluation to immediately before surgery. Surg Obes Relat Dis. 2011 Jan-Feb;7(1):50-4.

Inge TH, Xanthakos S. Sleeve gastrectomy for childhood morbid obesity: why not? Obes Surg. 2010 Jan;20(1):118-20.

Inge TH, Jenkins TM, Zeller M, Dolan L, Daniels SR, Garcia VF, Brandt ML, Bean J, Gamm K, Xanthakos SA. Baseline BMI is a strong predictor of nadir BMI after adolescent gastric bypass. J Pediatr. 2010 Jan;156(1):103-108.e1.

Miyano G, Kalra M, Inge TH. Adolescent paraplegia, morbid obesity, and pickwickian syndrome: outcome of gastric bypass surgery. J Pediatr Surg. 2009 Mar;44(3):e41-4.

Zeller MH, Modi AC, Noll JG, Long JD, Inge TH. Psychosocial functioning improves following adolescent bariatric surgery. Obesity (Silver Spring). 2009 May;17(5):985-90.

Inge TH, Miyano G, Bean J, Helmrath M, Courcoulas A, Harmon CM, Chen MK, Wilson K, Daniels SR, Garcia VF, Brandt ML, Dolan LM. Reversal of type 2 diabetes mellitus and improvements in cardiovascular risk factors after surgical weight loss in adolescents. Pediatrics. 2009 Jan;123(1):214-22.

Modi AC, Loux TJ, Bell SK, Harmon CM, Inge TH, Zeller MH. Weight-specific health-related quality of life in adolescents with extreme obesity. Obesity (Silver Spring). 2008 Oct;16(10):2266-71.

Ippisch HM, Inge TH, Daniels SR, Wang B, Khoury PR, Witt SA, Glascock BJ, Garcia VF, Kimball TR. Reversibility of cardiac abnormalities in morbidly obese adolescents. J Am Coll Cardiol. 2008 Apr 8;51(14):1342-8.

Inge TH. Childhood obesity--a problem of surgical proportions? Nat Clin Pract Gastroenterol Hepatol. 2008 Apr;5(4):180-1.