Clinical Interests

Pediatric sleep disorders; respiratory control disorders

Research Interests

Effect of nicotine exposure on the developing brainstem

MD: Faculty of Medicine, Siriraj Hospital, Mahidol University, Thailand, 1992.

Residency: Pediatrics, Children's Hospital of Michigan, Detroit, MI.

Fellowship: Pediatric Pulmonology and Sleep Medicine, Tulane University School of Medicine, New Orleans, LA.

Jain SV, Simakajornboon S, Shapiro SM, Morton LD, Leszczyszyn DJ, Simakajornboon N. Obstructive sleep apnea in children with epilepsy: prospective pilot trial. Acta Neurol Scand. 2011 Mar 17.

Bhattacharjee R, Kheirandish-Gozal L, Spruyt K, Mitchell RB, Promchiarak J, Simakajornboon N, Kaditis AG, Splaingard D, Splaingard M, Brooks LJ, Marcus CL, Sin S, Arens R, Verhulst SL, Gozal D. Adenotonsillectomy outcomes in treatment of obstructive sleep apnea in children: a multicenter retrospective study. Am J Respir Crit Care Med. 2010 Sep 1;182(5):676-83.

Ednick M, Cohen AP, McPhail GL, Beebe D, Simakajornboon N, Amin RS. A review of the effects of sleep during the first year of life on cognitive, psychomotor, and temperament development. Sleep. 2009 Nov 1;32(11):1449-58.

Ednick M, Tinkle BT, Phromchairak J, Egelhoff J, Amin R, Simakajornboon N. Sleep-related respiratory abnormalities and arousal pattern in achondroplasia during early infancy. J Pediatr. 2009 Oct;155(4):510-5.

Reeves SR, Simakajornboon N, Gozal D. The role of nitric oxide in the neural control of breathing. Respir Physiol Neurobiol. 2008 Dec 10;164(1-2):143-50.

Naqvi SK, Sotelo C, Murry L, Simakajornboon N. Sleep architecture in children and adolescents with cystic fibrosis and the association with severity of lung disease. Sleep Breath. 2008 Mar;12(1):77-83.

Simakajornboon N. Periodic limb movement disorder in children. Paediatr Respir Rev. 2006;7 Suppl 1:S55-7.

Simakajornboon N, Kuptanon T. Maturational changes in neuromodulation of central pathways underlying hypoxic ventilatory response. Respir Physiol Neurobiol. 2005 Nov 15;149(1-3):273-86.

Baber SR, Li H, Simakajornboon N, Kadowitz PJ, Ross-Ascuitto NT, Ascuitto RJ. Analysis of pulmonary vascular response to acute alveolar hypoxic challenge in young rabbits subjected to chronic hypoxia from birth. J Cardiovasc Pharmacol. 2005 May;45(5):431-8.

Simakajornboon N, Vlasic V, Li H, Sawnani H. Effect of prenatal nicotine exposure on biphasic hypoxic ventilatory response and protein kinase C expression in caudal brain stem of developing rats. J Appl Physiol. 2004 Jun;96(6):2213-9.

Clancy JP, Rowe SM, Accurso FJ, Aitken ML, Amin RS, Ashlock MA, Ballmann M, Boyle MP, Bronsveld I, Campbell PW, Deboeck K, Donaldson SH, Dorkin HL, Dunitz JM, Durie PR, Jain M, Leonard A, McCoy KS, Moss RB, Pilewski JM, Rosenbluth DB, Rubenstein RC, Schechter MS, Botfield M, Ordoñez CL, Spencer-Green GT, Vernillet L, Wisseh S, Yen K, Konstan MW. Results of a phase IIa study of VX-809, an investigational CFTR corrector compound, in subjects with cystic fibrosis homozygous for the F508del-CFTR mutation. Thorax. 2011 Aug 8. Epub ahead of print.

Sung V, Beebe DW, Vandyke R, Fenchel MC, Crimmins NA, Kirk S, Hiscock H, Amin R, Wake M. Does sleep duration predict metabolic risk in obese adolescents attending tertiary services? A cross-sectional study. Sleep. 2011 Jul 1;34(7):891-8.

Sawnani H, Murugappan S, Gutmark E, Donnelly LF, Amin R, Mylavarapu G, Mihaescu M, Khosla S, Kalra M. Influence of gender on pharyngeal airway length in obese adolescents. Ann Otol Rhinol Laryngol. 2010 Dec;119(12):842-7.

Beebe DW, Ris MD, Kramer ME, Long E, Amin R. The association between sleep disordered breathing, academic grades, and cognitive and behavioral functioning among overweight subjects during middle to late childhood. Sleep. 2010 Nov 1;33(11):1447-56. 

Beebe DW, Rose D, Amin R. Attention, learning, and arousal of experimentally sleep-restricted adolescents in a simulated classroom. J Adolesc Health. 2010 Nov;47(5):523-5. 

McPhail GL, Weiland J, Acton JD, Ednick M, Chima A, VanDyke R, Fenchel MC, Amin RS, Seid M. Improving evidence-based care in cystic fibrosis through quality improvement. Arch Pediatr Adolesc Med. 2010 Oct;164(10):957-60. 

McPhail GL, Ednick MD, Fenchel MC, VanDyke R, Chima A, Amin RS, Seid M. Improving follow-up in hospitalised children. Qual Saf Health Care. 2010 Oct;19(5):e35. 

Ednick M, Cohen AP, McPhail GL, Beebe D, Simakajornboon N, Amin RS. A review of the effects of sleep during the first year of life on cognitive, psychomotor, and temperament development. Sleep. 2009 Nov 1;32(11):1449-58. 

Ednick M, Tinkle BT, Phromchairak J, Egelhoff J, Amin R, Simakajornboon N. Sleep-related respiratory abnormalities and arousal pattern in achondroplasia during early infancy. J Pediatr. 2009 Oct;155(4):510-5. 

McConnell K, Somers VK, Kimball T, Daniels S, VanDyke R, Fenchel M, Cohen A, Willging P, Shamsuzzaman A, Amin R. Baroreflex gain in children with obstructive sleep apnea. Am J Respir Crit Care Med. 2009 Jul 1;180(1):42-8.

Outcome and development of children with brain injuries; outcome and development of children neurodevelopmental disorders; sleep and neurobehavioral functioning; professional development of emerging leaders

Visit the Beebe Lab.

PhD: Loyola University, Chicago, IL, 1998.

Fellowship: Pediatric Neuropsychology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 1998-2000.

Certifications: Clinical Psychology, Ohio State Board of Psychology, 1999; Diplomate in Clinical Neuropsychology, American Board of Professional Psychology and the American Board of Clinical Neuropsychology, 2005.

Byars KC, Yolton K, Rausch J, Lanphear B, Beebe DW. Sleep During Early Development: A Longitudinal Study of the Patterns, Prevalence, and Persistence of Sleep Problems in the First 3 Years of Life. Pediatrics. 2011. Epub ahead of print.

Beebe DW. A Primer on Sleep for Pediatric and Child Clinical Neuropsychologists. Child Neuropsychology. 2011. Epub ahead of print.

Redline S, Amin R, Beebe D, Chervin RD, Garetz SL, Giordani B, Marcus CL, Moore RH, Rosen CL, Arens R, Gozal D, Katz ES, Mitchell RB, Muzumdar H, Taylor HG, Thomas N, Ellenberg S. The Childhood Adenotonsillectomy Trial (CHAT): Rationale, Design, and Challenges of a Randomized Controlled Trial Evaluating a Standard Surgical Procedure in a Pediatric Population. Sleep. Nov 1;34(11):1509-17.

Beebe DW, Miller N, Kirk S, Daniels SR, Amin R. The association between obstructive sleep apnea and dietary choices. Sleep Medicine. 2011 Sep;12(8):797-9.

Beebe DW. Cognitive, behavioral, and functional consequences of inadequate sleep in children and adolescents. Pediatric Clinics of North America. 2011 Jun;58(3):649-65.

Beebe DW, Ris MD, Kramer ME, Long E, Amin R. The association between sleep disordered breathing, academic grades, and cognitive and behavioral functioning among overweight subjects during middle to late childhood. Sleep. 2010 Nov;33(11):1447-56.

Beebe DW, Rose D, Amin R. Brief report: performance of experimentally sleep-restricted adolescents in a simulated classroom. J Adolesc Health. 2010 Nov;47(5):523-5.

LeJeune B, Beebe D, Noll J, Kenealy L, Isquith P, Gioia G. Psychometric support for an abbreviated version of the Behavior Rating Inventory of Executive Function (BRIEF) Parent Form. Child Neuropsychol. 2010 Mar;16(2):182-201.

Uzark K, Spicer R, Beebe DW. Neurodevelopmental outcomes in pediatric heart transplant recipients. J Heart Lung Transplant. 2009 Dec;28(12):1306-11.

Beebe DW, Difrancesco MW, Tlustos SJ, McNally KA, Holland SK. Preliminary fMRI findings in experimentally sleep-restricted adolescents engaged in a working memory task. Behav Brain Funct. 2009 Feb 19;5:9.

Pediatric behavioral sleep medicine

PsyD: Georgia School of Professional Psychology, Atlanta, GA, 1998

Residency: Clinical Psychology / Developmental and Behavioral Pediatrics, The Kennedy Krieger Institute and Johns Hopkins University School of Medicine, Baltimore, MD.

Fellowship: Cincinnati Children' s Hospital Medical Center, Cincinnati, Ohio, 2000.

Certification: Licensure in Psychology, State of Ohio, 2000; National Register of Health Service Providers in Psychology, 2001; Certification in Behavioral Sleep Medicine, American Academy of Sleep Medicine, June 2005.

Beebe DW, Byars KC. Adolescents with obstructive sleep apnea adhere poorly to positive airway pressure (PAP), but PAP users show improved attention and school performance. PLoS One. 2011 Mar 17;6(3):e16924.

Byars K, Apiwattanasawee P, Leejakpai A, Tangchityongsiva S, Simakajornboom N. Behavioral sleep disturbances in children clinically referred for evaluation of obstructive sleep apnea. Sleep Med. 2011 Feb;12(2):163-9.

Byars AW, Byars KC, Johnson CS, DeGrauw TJ, Fastenau PS, Perkins S, Austin JK, Dunn DW. The relationship between sleep problems and neuropsychological functioning in children with first recognized seizures. Epilepsy Behav. 2008 Nov;13(4):607-13. 

Meltzer L, Mindell J, Owens J, Byars KC. The Use of Sleep Medications in Hospitalized Pediatric Patients. Pediatrics. 2007;119(6):1047–55.

Book Chapters

Byars, K. Scheduled awakenings: A behavioral protocol for treating sleepwalking and sleep terrors in children. In M. Perlis, M. Aloia, and B.Kuhn, (Eds.) Behavioral treatments for sleep disorders: A comprehensive primer of behavioral sleep medicine interventions. London: London: Elsevier Academic Press, 2010.

Byars KC, Amin R. Fatigue and Sleep Disorders. In G. Slapp (Ed.) Adolescent Medicine: The Requisites in Pediatrics. Philadelphia: Elsevier Press, 2008.

Fricke BL, Donnelly LF, Shott SR, Kalra M, Poe SA, Chini BA, Amin RS. Comparison of lingual tonsil size as depicted on MR imaging between children with obstructive sleep apnea despite previous tonsillectomy and adenoidectomy and normal controls. Pediatr Radiol. 2006 Jun;36(6):518-23. Epub 2006 Apr 5.

Shott SR, Amin R, Chini B, Heubi C, Hotze S, Akers R. Obstructive sleep apnea – Should all children with Down syndrome be tested? Arch Otolaryngol Head Neck Surg. 2006 Apr;132(4):432-436.

Mannaa M, Chini B. A case in point. A boy with shortness of breath, cough, and myalgia’s. J Respiratory Diseases. 2006;27(8):356-8.

Beebe DW, Wells CT, Jeffries J, Chini B, Kalra M, Amin RS. Neuropsychological Effects of Pediatric Obstructive Sleep Apnea. JINS. 2004 Nov;10(7):962-975.

Abbott MB, Donnelly LF, Dardzinski BJ, Poe SA, Chini BA, Amin RS. Obstructive Sleep Apnea: MR Imaging Volume Segmentation Analysis. Radiology. 2004 Sep;232(3):889-895.

Amin RS, Carroll J, Bean J, Jeffries J, Chini B, Bokulic R, Daniels S. Twenty Four Hour Ambulatory Blood Pressure in Children with Obstructive Sleep Apnea. Am J Respir Crit Care Med. 2004 Apr;169(8):950-56.

Donnelly LF, Shott SR, Connor RL, Chini BA, Amin RS. Causes of Persistent Obstructive Sleep Apnea Despite Previous Tonsillectomy and Adenoidectomy in Children with Down Syndrome as Depicted on Static and Dynamic Cine MRI. AJR. 2004 Jul;183(1):175-181.

Clinical Interests

Medical and surgical management of Epilepsy; Sleep disorders

Research Interests

Sleep disorders in children with epilepsy; Clinical drug trials

Jain SV, Horn PS, Simakajornboon N, Glauser, TA. Obstructive sleep apnea and primary snoring in children with epilepsy. Journal of child neurology. (Accepted)

Fujiwara H, Greiner HM, Hemasilpin N, Lee KH, Holland-Bouley K, Arthur T, Morita D, Jain SV, Mangano FT, Degrauw T, Rose DF. Ictal MEG onset source localization compared to intracranial EEG and outcome: Improved epilepsy presurgical evaluation in pediatrics. Epilepsy Res. 2011 Dec 16. [Epub]

Jain SV, Kothare SV. Should we be targeting the sleep-wake patterns of children with epilepsy?Neuropsychiatry 2011 1(6), 517–520 ISSN 1758-2008

Jain SV, Simakajornboon S, Shapiro SM, Morton LD, Leszczyszyn DJ, Simakajornboon. Obstructive Sleep Apnea in Children with Epilepsy: Prospective Pilot Trial. Acta Neurologica Scandinavica. 2011 March 17. Epub ahead of print.

Jain SV, Morton LD. Ischemic stroke and excellent recovery after intravenous tissue plasminogen activator. Pediatric Neurology. 2008;38:126-129.

Book Chapters

Jain SV, Morton LD. Evaluating the child with seizure: In Pellock JM, Dodson EW, Bourgeois BF, and Nordlii DR: Pediatric Epilepsy, diagnosis and treatment. New York: Demos Medical Publishing, 2007.

Sleep-disordered breathing in children

Clinical Interests

Medical Education; outcomes research; quality improvement; sleep medicine; thoracic insufficiency syndrome

Research Interests

Medical Education; Pulmonary Vascular Disease; Thoracic Insufficiency Syndrome

McPhail GL, Weiland J, Acton JD, Ednick M, Chima A, VanDyke R, Fenchel MC, Amin RS, Seid M. Improving evidence-based care in cystic fibrosis through quality improvement.Arch Pediatr Adolesc Med. 2010 Oct;164(10):957-60.

McPhail GL, Ednick MD, Fenchel MC, VanDyke R, Chima A, Amin RS, Seid M. Improving follow-up in hospitalised children. Qual Saf Health Care. 2010 Oct;19(5):e35

Ednick M, Cohen AP, McPhail GL, Beebe D, Simakajornboon N, Amin RS. A review of the effects of sleep during the first year of life on cognitive, psychomotor, and temperament development. Sleep. 2009 Nov 1;32(11):1449-58. Review.

McPhail GL, Acton JD, Fenchel MC, Amin RS, Seid M. Improvements in lung function outcomes in children with cystic fibrosis are associated with better nutrition, fewer chronic pseudomonas aeruginosa infections, and dornase alfa use.J Pediatr. 2008 Dec;153(6):752-7.

McPhail GL. Coagulation disorder as a presentation of cystic fibrosis. J Emerg Med. 2010 Apr;38(3):320-2.

Amin R, Somers VK, McConnell K, Willging P, Myer C, Sherman M, McPhail G, Morgenthal A, Fenchel M, Bean J, Kimball T, Daniels S. Activity-adjusted 24-hour ambulatory blood pressure and cardiac remodeling in children with sleep disordered breathing.Hypertension. 2008 Jan;51(1):84-91.

McPhail GL, Hardie WD. Cavitary lung lesions in a 2-year-old child.Respiration. 2008;76(1):117-8.

Pediatric sleep disorders

MD: Seth GS Meidcal College/King Edward VIII Memorial Hospital, 1997.

Residency: Pediatrics, Brooklyn Hospital Medical Center, New York NY, 2000.

Fellowship: Pediatric Pulmonology, Tulane Medical Center, New Orleans LA, 2003; Sleep Medicine, Cincinnati Children's Hospital, Cincinnati OH, 2008.

Certification: Pediatrics, 2000, recertified 2007; Pediatric Pulmonology, 2004.